CA2133974A1 - Fibrin coated polymer surfaces - Google Patents
Fibrin coated polymer surfacesInfo
- Publication number
- CA2133974A1 CA2133974A1 CA002133974A CA2133974A CA2133974A1 CA 2133974 A1 CA2133974 A1 CA 2133974A1 CA 002133974 A CA002133974 A CA 002133974A CA 2133974 A CA2133974 A CA 2133974A CA 2133974 A1 CA2133974 A1 CA 2133974A1
- Authority
- CA
- Canada
- Prior art keywords
- fibrinogen
- coated
- fibrin
- polymeric materials
- produce
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/06—Use of macromolecular materials
- A61L33/12—Polypeptides, proteins or derivatives thereof, e.g. degradation products thereof
- A61L33/126—Fibrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
Abstract
Surfaces of polymeric materials are coated with a layer of thermally denatured fibrinogen. The fibrinogen may be treated with thrombin to produce fibrin, and additional fibrinogen and factor XIII
added to produce a cross-linked fibrin coating. The resulting coated surface is stable, anti-thrombotic and resistant to platelet adhesion. Polymeric materials coated in this way are useful in constructing vascular grafts and.prosthetic devices, and provide test systems useful in the study of thrombogenesis.
added to produce a cross-linked fibrin coating. The resulting coated surface is stable, anti-thrombotic and resistant to platelet adhesion. Polymeric materials coated in this way are useful in constructing vascular grafts and.prosthetic devices, and provide test systems useful in the study of thrombogenesis.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/872,483 | 1992-04-23 | ||
US07/872,483 US5272074A (en) | 1992-04-23 | 1992-04-23 | Fibrin coated polymer surfaces |
PCT/US1993/003651 WO1993021971A1 (en) | 1992-04-23 | 1993-04-16 | Fibrin coated polymer surfaces |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2133974A1 true CA2133974A1 (en) | 1993-11-11 |
CA2133974C CA2133974C (en) | 2005-03-22 |
Family
ID=25359652
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002133974A Expired - Lifetime CA2133974C (en) | 1992-04-23 | 1993-04-16 | Fibrin coated polymer surfaces |
Country Status (10)
Country | Link |
---|---|
US (2) | US5272074A (en) |
EP (1) | EP0639087B1 (en) |
JP (1) | JP3621412B2 (en) |
AT (1) | ATE147276T1 (en) |
CA (1) | CA2133974C (en) |
DE (1) | DE69307305T2 (en) |
DK (1) | DK0639087T3 (en) |
ES (1) | ES2098748T3 (en) |
GR (1) | GR3022908T3 (en) |
WO (1) | WO1993021971A1 (en) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5792835A (en) * | 1991-09-05 | 1998-08-11 | Baxter International Inc. | Method of preparing a topical fibrinogen complex |
US5599352A (en) * | 1992-03-19 | 1997-02-04 | Medtronic, Inc. | Method of making a drug eluting stent |
CN1091315A (en) * | 1992-10-08 | 1994-08-31 | E·R·斯奎布父子公司 | Fibrin sealant compositions and using method thereof |
US5531789A (en) * | 1993-12-24 | 1996-07-02 | Sun Medical Technology Research Corporation | Sealing system of an artificial internal organ |
US5639940A (en) | 1994-03-03 | 1997-06-17 | Pharmaceutical Proteins Ltd. | Production of fibrinogen in transgenic animals |
US5665114A (en) * | 1994-08-12 | 1997-09-09 | Meadox Medicals, Inc. | Tubular expanded polytetrafluoroethylene implantable prostheses |
US5660873A (en) * | 1994-09-09 | 1997-08-26 | Bioseal, Limited Liability Corporaton | Coating intraluminal stents |
US5643580A (en) * | 1994-10-17 | 1997-07-01 | Surface Genesis, Inc. | Biocompatible coating, medical device using the same and methods |
AU697045B2 (en) * | 1995-01-16 | 1998-09-24 | Baxter International Inc. | Self-supporting sheet-like material of cross-linked fibrin for preventing post- operative adhesions |
US5665077A (en) * | 1995-04-24 | 1997-09-09 | Nitrosci Pharmaceuticals Llc | Nitric oxide-releasing nitroso compositions and methods and intravascular devices for using them to prevent restenosis |
US5609631A (en) * | 1995-04-28 | 1997-03-11 | Rubens; Fraser D. | Fibrin D-domain multimer coated prostheses and methods for their production |
JP3318578B2 (en) * | 1995-05-26 | 2002-08-26 | サーモディックス,インコーポレイティド | Methods for promoting endothelialization and implantable products |
MX9602398A (en) * | 1995-06-23 | 1997-02-28 | Kimberly Clark Co | Modified polymeric material having improved wettability. |
US5891506A (en) * | 1996-08-09 | 1999-04-06 | Medtronic, Inc. | Oxidative method for attachment of glycoproteins or glycopeptides to surfaces of medical devices |
US5821343A (en) * | 1996-04-25 | 1998-10-13 | Medtronic Inc | Oxidative method for attachment of biomolecules to surfaces of medical devices |
US5728420A (en) * | 1996-08-09 | 1998-03-17 | Medtronic, Inc. | Oxidative method for attachment of glycoproteins to surfaces of medical devices |
EP0917444A1 (en) | 1996-07-12 | 1999-05-26 | Baxter Travenol Laboratories, Inc. | A fibrin delivery device and method for forming fibrin on a surface |
US6162537A (en) | 1996-11-12 | 2000-12-19 | Solutia Inc. | Implantable fibers and medical articles |
US6150505A (en) * | 1997-09-19 | 2000-11-21 | Hadasit Medical Research Services & Development Ltd. | Fibrin microbeads prepared from fibrinogen, thrombin and factor XIII |
US7070607B2 (en) * | 1998-01-27 | 2006-07-04 | The Regents Of The University Of California | Bioabsorbable polymeric implants and a method of using the same to create occlusions |
BE1012536A3 (en) * | 1998-11-04 | 2000-12-05 | Baxter Int | Element with a layer fibrin its preparation and use. |
AU765315B2 (en) | 1998-11-19 | 2003-09-18 | Pharming Intellectual Property Bv | Stabilisation of milk from transgenic animals |
US6921412B1 (en) | 1999-05-18 | 2005-07-26 | Cryolife, Inc. | Self-supporting, shaped, three-dimensional biopolymeric materials and methods |
WO2000072857A1 (en) * | 1999-06-01 | 2000-12-07 | Bristol-Myers Squibb Company | Fibrin polymer structure |
EP1416946B1 (en) * | 2000-11-07 | 2017-12-20 | CryoLife, Inc. | Expandable foam-like biomaterials and methods |
US6913762B2 (en) * | 2001-04-25 | 2005-07-05 | Mayo Foundation For Medical Education And Research | Stent having non-woven framework containing cells |
US6552172B2 (en) | 2001-08-30 | 2003-04-22 | Habto Biotech, Inc. | Fibrin nanoparticles and uses thereof |
US7135027B2 (en) * | 2002-10-04 | 2006-11-14 | Baxter International, Inc. | Devices and methods for mixing and extruding medically useful compositions |
FR2847819B1 (en) * | 2002-12-03 | 2006-05-19 | Univ Cergy Pontoise | PROCESS FOR THE PREPARATION OF A CONDUCTIVE MATERIAL WITH FIBRINOLYTIC ACTIVITY IMPLANTABLE IN THE ORGANISM |
US20050032205A1 (en) * | 2003-08-05 | 2005-02-10 | Smith Sidney T. | In vitro cell culture employing a fibrin network in a flexible gas permeable container |
CA2584679C (en) | 2004-10-20 | 2015-01-27 | Ethicon, Inc. | Hemostat |
US9358318B2 (en) | 2004-10-20 | 2016-06-07 | Ethicon, Inc. | Method of making a reinforced absorbable multilayered hemostatic wound dressing |
US20060258995A1 (en) * | 2004-10-20 | 2006-11-16 | Pendharkar Sanyog M | Method for making a reinforced absorbable multilayered fabric for use in medical devices |
WO2006065739A2 (en) * | 2004-12-14 | 2006-06-22 | Millennium Pharmaceuticals, Inc | A device for aggregating, imaging and analyzing thrombi and a method of use |
US9259535B2 (en) | 2006-06-22 | 2016-02-16 | Excelsior Medical Corporation | Antiseptic cap equipped syringe |
US11229746B2 (en) | 2006-06-22 | 2022-01-25 | Excelsior Medical Corporation | Antiseptic cap |
CZ299687B6 (en) * | 2006-12-21 | 2008-10-22 | Ústav makromolekulární chemie AV CR, v.v.i. | Process for preparing controlled layers of fibrin on solid surfaces |
ES2438491T3 (en) * | 2008-09-22 | 2014-01-17 | Omrix Biopharmaceuticals Ltd. | Implantable device comprising a substrate pre-coated with stabilized fibrin |
US9078992B2 (en) | 2008-10-27 | 2015-07-14 | Pursuit Vascular, Inc. | Medical device for applying antimicrobial to proximal end of catheter |
WO2010131249A2 (en) | 2009-05-12 | 2010-11-18 | Hadasit Medical Research Services And Development Ltd. | Prosthetic devices coated with heated cross-linked fibrin |
PL2435102T3 (en) * | 2009-05-28 | 2021-01-11 | Addbio Ab | Multilayer protein films, methods of making, and drug delivery devices and biomedical implants employing the films |
EP2731658B1 (en) | 2011-07-12 | 2020-04-01 | Pursuit Vascular, Inc. | Device for delivery of antimicrobial agent into trans-dermal catheter |
US9724213B2 (en) | 2012-11-19 | 2017-08-08 | Washington State University | Nanocrystalline cellulose materials and methods for their preparation |
CA2982456A1 (en) | 2015-05-08 | 2016-11-17 | Icu Medical, Inc. | Medical connectors configured to receive emitters of therapeutic agents |
SI3525865T1 (en) | 2016-10-14 | 2023-01-31 | Icu Medical, Inc. | Sanitizing caps for medical connectors |
WO2018204206A2 (en) | 2017-05-01 | 2018-11-08 | Icu Medical, Inc. | Medical fluid connectors and methods for providing additives in medical fluid lines |
US11541221B2 (en) | 2018-11-07 | 2023-01-03 | Icu Medical, Inc. | Tubing set with antimicrobial properties |
US11517732B2 (en) | 2018-11-07 | 2022-12-06 | Icu Medical, Inc. | Syringe with antimicrobial properties |
US11541220B2 (en) | 2018-11-07 | 2023-01-03 | Icu Medical, Inc. | Needleless connector with antimicrobial properties |
US11400195B2 (en) | 2018-11-07 | 2022-08-02 | Icu Medical, Inc. | Peritoneal dialysis transfer set with antimicrobial properties |
US11534595B2 (en) | 2018-11-07 | 2022-12-27 | Icu Medical, Inc. | Device for delivering an antimicrobial composition into an infusion device |
CA3118905A1 (en) | 2018-11-21 | 2020-05-28 | Icu Medical, Inc. | Antimicrobial device comprising a cap with ring and insert |
CA3204371A1 (en) | 2020-12-07 | 2022-06-16 | Icu Medical, Inc. | Peritoneal dialysis caps, systems and methods |
CN113117158B (en) * | 2021-03-10 | 2022-07-26 | 复旦大学 | Material for biological functional modification of surface denatured protein and preparation method and application thereof |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4167045A (en) * | 1977-08-26 | 1979-09-11 | Interface Biomedical Laboratories Corp. | Cardiac and vascular prostheses |
US4273873A (en) * | 1977-10-25 | 1981-06-16 | Unitika Ltd. | Preparation of antithrombogenic polymeric materials |
US4534069A (en) * | 1984-01-27 | 1985-08-13 | Kelman Charles D | Intraocular lens and method of positioning the same in an eye |
US4627879A (en) * | 1984-09-07 | 1986-12-09 | The Trustees Of Columbia University In The City Of New York | Fibrin adhesive prepared as a concentrate from single donor fresh frozen plasma |
US5230693A (en) * | 1985-06-06 | 1993-07-27 | Thomas Jefferson University | Implantable prosthetic device for implantation into a human patient having a surface treated with microvascular endothelial cells |
US5266476A (en) * | 1985-06-18 | 1993-11-30 | Yeda Research & Development Co., Ltd. | Fibrous matrix for in vitro cell cultivation |
SE459432B (en) * | 1986-01-31 | 1989-07-03 | Widen Innovation Ab | CYLINDERLASES AND SUPPLIERS AND KEY SHEETS FOR USE IN COMBINATION WITH THIS |
ES2004281A6 (en) * | 1986-04-04 | 1988-12-16 | Univ Jefferson | Method of treating a synthetic naturally occurring surface with a collagen laminate to support microvascular endothelial cell growth, and the surface itself |
EP0290642B1 (en) * | 1987-05-12 | 1993-11-03 | Mittermayer, Christian, Dr. med. | Method for seeding polymeric surfaces with human endothelial cells |
EP0366564B1 (en) * | 1988-10-28 | 1995-07-12 | Terumo Kabushiki Kaisha | Antithrombic medical material, artificial internal organ, and method for production of antithrombic medical material |
JP2678945B2 (en) * | 1989-04-17 | 1997-11-19 | 有限会社ナイセム | Artificial blood vessel, method for producing the same, and substrate for artificial blood vessel |
NZ237832A (en) * | 1990-04-17 | 1994-05-26 | Curative Tech Inc | Coating a prosthetic surface with mammalian cells |
-
1992
- 1992-04-23 US US07/872,483 patent/US5272074A/en not_active Expired - Lifetime
-
1993
- 1993-04-16 EP EP93912306A patent/EP0639087B1/en not_active Expired - Lifetime
- 1993-04-16 ES ES93912306T patent/ES2098748T3/en not_active Expired - Lifetime
- 1993-04-16 DK DK93912306.3T patent/DK0639087T3/en active
- 1993-04-16 AT AT93912306T patent/ATE147276T1/en active
- 1993-04-16 JP JP51932693A patent/JP3621412B2/en not_active Expired - Lifetime
- 1993-04-16 WO PCT/US1993/003651 patent/WO1993021971A1/en active IP Right Grant
- 1993-04-16 DE DE69307305T patent/DE69307305T2/en not_active Expired - Lifetime
- 1993-04-16 CA CA002133974A patent/CA2133974C/en not_active Expired - Lifetime
- 1993-09-14 US US08/121,327 patent/US5324647A/en not_active Expired - Lifetime
-
1997
- 1997-03-26 GR GR970400593T patent/GR3022908T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
US5272074A (en) | 1993-12-21 |
JP3621412B2 (en) | 2005-02-16 |
US5324647A (en) | 1994-06-28 |
DK0639087T3 (en) | 1997-06-16 |
CA2133974C (en) | 2005-03-22 |
GR3022908T3 (en) | 1997-06-30 |
EP0639087B1 (en) | 1997-01-08 |
DE69307305T2 (en) | 1997-05-15 |
EP0639087A1 (en) | 1995-02-22 |
ES2098748T3 (en) | 1997-05-01 |
DE69307305D1 (en) | 1997-02-20 |
ATE147276T1 (en) | 1997-01-15 |
JPH07505812A (en) | 1995-06-29 |
WO1993021971A1 (en) | 1993-11-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request |