CA2134680A1 - Tissue-specific implantable therapeutic agent delivery system - Google Patents
Tissue-specific implantable therapeutic agent delivery systemInfo
- Publication number
- CA2134680A1 CA2134680A1 CA002134680A CA2134680A CA2134680A1 CA 2134680 A1 CA2134680 A1 CA 2134680A1 CA 002134680 A CA002134680 A CA 002134680A CA 2134680 A CA2134680 A CA 2134680A CA 2134680 A1 CA2134680 A1 CA 2134680A1
- Authority
- CA
- Canada
- Prior art keywords
- tissue
- therapeutic agent
- delivery system
- agent delivery
- therapeutic agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
- Y10S623/915—Method or apparatus for preparing biological material
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S707/00—Data processing: database and file management or data structures
- Y10S707/912—Applications of a database
- Y10S707/942—Legal/academic
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S707/00—Data processing: database and file management or data structures
- Y10S707/99931—Database or file accessing
- Y10S707/99933—Query processing, i.e. searching
- Y10S707/99934—Query formulation, input preparation, or translation
Abstract
A system for tissue-specific delivery of therapeutic agents includes an implantable element biodegradable in situ within human tissue; a vasoinductive agent integrated into a surface of the element;
and having the therapeutic agents incorporated into the implantable element. The figure shows a method of construction of a tubule in which there is a plurality of concentric, hollow tubules (e.g. 100, 200, 300). Upon implantation of the implantable element into the tissue, the vasoinductive agent stimulates capillary growth, facilitating delivery of the therapeutic agents to the selected tissue.
and having the therapeutic agents incorporated into the implantable element. The figure shows a method of construction of a tubule in which there is a plurality of concentric, hollow tubules (e.g. 100, 200, 300). Upon implantation of the implantable element into the tissue, the vasoinductive agent stimulates capillary growth, facilitating delivery of the therapeutic agents to the selected tissue.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/876,783 US5326568A (en) | 1991-05-03 | 1992-04-30 | Method of tissue-specific delivery |
US876,783 | 1992-04-30 | ||
PCT/US1993/004287 WO1993021859A1 (en) | 1992-04-30 | 1993-04-26 | Tissue-specific implantable therapeutic agent delivery system |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2134680A1 true CA2134680A1 (en) | 1993-11-11 |
CA2134680C CA2134680C (en) | 2004-11-30 |
Family
ID=25368571
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002134680A Expired - Fee Related CA2134680C (en) | 1992-04-30 | 1993-04-26 | Tissue-specific implantable therapeutic agent delivery system |
Country Status (6)
Country | Link |
---|---|
US (4) | US5326568A (en) |
EP (1) | EP0637946A4 (en) |
JP (1) | JPH08500088A (en) |
AU (1) | AU4370593A (en) |
CA (1) | CA2134680C (en) |
WO (1) | WO1993021859A1 (en) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5651976A (en) * | 1993-06-17 | 1997-07-29 | The United States Of America As Represented By The Secretary Of The Navy | Controlled release of active agents using inorganic tubules |
JPH08503715A (en) * | 1993-09-24 | 1996-04-23 | バクスター、インターナショナル、インコーポレイテッド | Method for promoting vascularization of implantable devices |
DK1125577T3 (en) * | 1994-04-08 | 2006-06-19 | Qlt Usa Inc | Liquid drug delivery preparations |
US6911216B1 (en) | 1994-10-12 | 2005-06-28 | Genzyme Corporation | Targeted delivery via biodegradable polymers |
US5782789A (en) * | 1994-10-19 | 1998-07-21 | Atrium Medical Corporation | Macrochannel phosthetic/delivery patch |
US5660848A (en) * | 1994-11-02 | 1997-08-26 | The Population Council, Center For Biomedical Research | Subdermally implantable device |
FI954565A0 (en) * | 1995-09-27 | 1995-09-27 | Biocon Oy | Biologically applied polymeric material to the implant and foil preparation |
US5869041A (en) * | 1996-01-12 | 1999-02-09 | The Miriam Hospital | Delivery of bioactive compounds to an organism |
EP0941116B1 (en) * | 1996-11-01 | 2005-01-19 | Ark Therapeutics Limited | Use of vegf for the manufacture of a medicament for the treatment or prevention of intimal hyperplasia and delivery device |
US20080305999A1 (en) * | 1996-11-01 | 2008-12-11 | John Francis Martin | Therapeutic use of growth factor, and delivery device, especially for the treatment of intimal hyperplasia |
US6203813B1 (en) | 1997-01-13 | 2001-03-20 | Lance L. Gooberman | Pharmaceutical delivery device and method of preparation therefor |
EP1089785A1 (en) | 1998-06-22 | 2001-04-11 | Neovasys, Inc. | Method, implant and delivery system for enhancing blood flow in tissue |
US6921412B1 (en) | 1999-05-18 | 2005-07-26 | Cryolife, Inc. | Self-supporting, shaped, three-dimensional biopolymeric materials and methods |
JP2003500174A (en) * | 1999-05-27 | 2003-01-07 | フアルマシア・コーポレーシヨン | Biomaterials modified with superoxide dismutase mimics |
US7039863B1 (en) * | 1999-07-23 | 2006-05-02 | Adobe Systems Incorporated | Computer generation of documents using layout elements and content elements |
US6618698B1 (en) * | 1999-08-12 | 2003-09-09 | Quickturn Design Systems, Inc. | Clustered processors in an emulation engine |
WO2002085284A2 (en) * | 2000-11-07 | 2002-10-31 | Cryolife, Inc. | Expandable foam-like biomaterials and methods |
US8539334B2 (en) | 2000-12-27 | 2013-09-17 | Tractmanager, Inc. | Document management system having automatic notifications |
US10114821B2 (en) * | 2000-12-27 | 2018-10-30 | Tractmanager, Inc. | Method and system to access to electronic business documents |
WO2003002100A1 (en) * | 2001-06-26 | 2003-01-09 | Farrell John J | Tamper-proof narcotic delivery system |
FR2839645B1 (en) * | 2002-05-15 | 2005-08-05 | Backert Marie Elisabeth Cuine | MULTILAMELLAR SYSTEM FOR THE ADMINISTRATION OF ACTIVE SUBSTANCES (IN PARTICULAR DRUGS) BY ORAL INGESTION |
JP2006512693A (en) | 2002-12-30 | 2006-04-13 | トムソン コーポレイション | A knowledge management system for law firms. |
DE10361940A1 (en) * | 2003-12-24 | 2005-07-28 | Restate Patent Ag | Degradation control of biodegradable implants by coating |
US7716206B2 (en) * | 2004-11-01 | 2010-05-11 | At&T Intellectual Property I, L.P. | Communication networks and methods and computer program products for performing searches thereon while maintaining user privacy |
US8234137B2 (en) * | 2005-10-03 | 2012-07-31 | Stellar Services | One view integrated project management system |
US20080059494A1 (en) * | 2006-09-01 | 2008-03-06 | Ean Rouse Schuessler | Document database system and method |
US20080183766A1 (en) * | 2007-01-31 | 2008-07-31 | Weston David W | Methods and systems for inductive data transformation |
US8024315B2 (en) * | 2007-07-20 | 2011-09-20 | International Business Machines Corporation | Method of dynamically providing a compound object's source information during its development |
US8316314B2 (en) | 2010-06-30 | 2012-11-20 | Thermo Electron Scientific Instruments Llc | Intelligent multi-functional macros language for analytical measurements |
US10420923B1 (en) | 2010-08-10 | 2019-09-24 | Amiram Katz | Method and device for intrathecal administering of immunoglobulin |
US10817508B2 (en) * | 2010-12-13 | 2020-10-27 | Micro Focus Llc | Techniques for constructing and editing a search query using an overload cell |
US8551525B2 (en) | 2010-12-23 | 2013-10-08 | Biostructures, Llc | Bone graft materials and methods |
US20150066556A1 (en) * | 2013-08-29 | 2015-03-05 | Steve Dominick | System and method for an electronic document management and review tool for litigation matters |
CN103593447B (en) * | 2013-11-18 | 2017-02-08 | 北京国双科技有限公司 | Data processing method and device applied to database table |
US20150363887A1 (en) * | 2014-06-11 | 2015-12-17 | Joe Ferri | System for tracking and attributing credit accrued through geographically dispersed representation |
US9808608B2 (en) * | 2014-11-16 | 2017-11-07 | International Business Machines Corporation | Helical coil delivery device for active agent |
US20180293091A1 (en) * | 2015-07-15 | 2018-10-11 | Mitsubishi Electric Corporation | Display control apparatus and display control method |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3625214A (en) * | 1970-05-18 | 1971-12-07 | Alza Corp | Drug-delivery device |
CA1045977A (en) * | 1973-05-17 | 1979-01-09 | Arthur D. Little | Biodegradable, implantable drug delivery device, and process for preparing and using the same |
US4939689A (en) * | 1987-04-09 | 1990-07-03 | Crowninshield Software, Inc. | Outline-driven database editing and retrieval system |
US4952403A (en) * | 1987-06-19 | 1990-08-28 | President And Fellows Of Harvard College | Implants for the promotion of healing of meniscal tissue |
EP0528971B1 (en) * | 1990-05-14 | 1999-09-01 | JERNBERG, Gary R. | Surgical implant and method incorporating chemotherapeutic agents |
EP0463194A1 (en) * | 1990-06-23 | 1992-01-02 | Boehringer Ingelheim Kg | Process for the preparation of poly(D,L-lactide) and its use as a drug carrier |
US6178413B1 (en) * | 1998-05-20 | 2001-01-23 | Technolines, Llc | Database program with automatic creation of user features |
US6182069B1 (en) * | 1992-11-09 | 2001-01-30 | International Business Machines Corporation | Video query system and method |
US5428735A (en) * | 1992-12-28 | 1995-06-27 | International Business Machines Corporation | Method and apparatus for maintaining a record of set-creating data processing activities and associated data sets |
US5649182A (en) * | 1995-03-17 | 1997-07-15 | Reitz; Carl A. | Apparatus and method for organizing timeline data |
US5787418A (en) * | 1996-09-03 | 1998-07-28 | International Business Machine Corporation | Find assistant for creating database queries |
US5924089A (en) * | 1996-09-03 | 1999-07-13 | International Business Machines Corporation | Natural language translation of an SQL query |
US6067568A (en) * | 1996-12-10 | 2000-05-23 | International Business Machines Corporation | Automatic setup of services for computer system users |
FI106990B (en) * | 1996-12-31 | 2001-05-15 | Nokia Mobile Phones Ltd | A method of transmitting information to a user |
KR19980076633A (en) * | 1997-04-11 | 1998-11-16 | 윤종용 | Information retrieval apparatus and method in mobile information terminal |
-
1992
- 1992-04-30 US US07/876,783 patent/US5326568A/en not_active Expired - Fee Related
-
1993
- 1993-04-26 WO PCT/US1993/004287 patent/WO1993021859A1/en not_active Application Discontinuation
- 1993-04-26 EP EP93913809A patent/EP0637946A4/en not_active Withdrawn
- 1993-04-26 JP JP5519630A patent/JPH08500088A/en active Pending
- 1993-04-26 CA CA002134680A patent/CA2134680C/en not_active Expired - Fee Related
- 1993-04-26 AU AU43705/93A patent/AU4370593A/en not_active Abandoned
- 1993-06-28 US US08/082,419 patent/US5494677A/en not_active Expired - Fee Related
-
2000
- 2000-10-31 US US09/703,482 patent/US7031960B1/en not_active Ceased
-
2007
- 2007-12-27 US US11/965,372 patent/USRE43391E1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0637946A1 (en) | 1995-02-15 |
US7031960B1 (en) | 2006-04-18 |
USRE43391E1 (en) | 2012-05-15 |
AU4370593A (en) | 1993-11-29 |
US5326568A (en) | 1994-07-05 |
JPH08500088A (en) | 1996-01-09 |
EP0637946A4 (en) | 1996-09-11 |
WO1993021859A1 (en) | 1993-11-11 |
US5494677A (en) | 1996-02-27 |
CA2134680C (en) | 2004-11-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |