CA2134680A1 - Tissue-specific implantable therapeutic agent delivery system - Google Patents

Tissue-specific implantable therapeutic agent delivery system

Info

Publication number
CA2134680A1
CA2134680A1 CA002134680A CA2134680A CA2134680A1 CA 2134680 A1 CA2134680 A1 CA 2134680A1 CA 002134680 A CA002134680 A CA 002134680A CA 2134680 A CA2134680 A CA 2134680A CA 2134680 A1 CA2134680 A1 CA 2134680A1
Authority
CA
Canada
Prior art keywords
tissue
therapeutic agent
delivery system
agent delivery
therapeutic agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002134680A
Other languages
French (fr)
Other versions
CA2134680C (en
Inventor
Vincent C. Giampapa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2134680A1 publication Critical patent/CA2134680A1/en
Application granted granted Critical
Publication of CA2134680C publication Critical patent/CA2134680C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/915Method or apparatus for preparing biological material
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S707/00Data processing: database and file management or data structures
    • Y10S707/912Applications of a database
    • Y10S707/942Legal/academic
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S707/00Data processing: database and file management or data structures
    • Y10S707/99931Database or file accessing
    • Y10S707/99933Query processing, i.e. searching
    • Y10S707/99934Query formulation, input preparation, or translation

Abstract

A system for tissue-specific delivery of therapeutic agents includes an implantable element biodegradable in situ within human tissue; a vasoinductive agent integrated into a surface of the element;
and having the therapeutic agents incorporated into the implantable element. The figure shows a method of construction of a tubule in which there is a plurality of concentric, hollow tubules (e.g. 100, 200, 300). Upon implantation of the implantable element into the tissue, the vasoinductive agent stimulates capillary growth, facilitating delivery of the therapeutic agents to the selected tissue.
CA002134680A 1992-04-30 1993-04-26 Tissue-specific implantable therapeutic agent delivery system Expired - Fee Related CA2134680C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/876,783 US5326568A (en) 1991-05-03 1992-04-30 Method of tissue-specific delivery
US876,783 1992-04-30
PCT/US1993/004287 WO1993021859A1 (en) 1992-04-30 1993-04-26 Tissue-specific implantable therapeutic agent delivery system

Publications (2)

Publication Number Publication Date
CA2134680A1 true CA2134680A1 (en) 1993-11-11
CA2134680C CA2134680C (en) 2004-11-30

Family

ID=25368571

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002134680A Expired - Fee Related CA2134680C (en) 1992-04-30 1993-04-26 Tissue-specific implantable therapeutic agent delivery system

Country Status (6)

Country Link
US (4) US5326568A (en)
EP (1) EP0637946A4 (en)
JP (1) JPH08500088A (en)
AU (1) AU4370593A (en)
CA (1) CA2134680C (en)
WO (1) WO1993021859A1 (en)

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JPH08503715A (en) * 1993-09-24 1996-04-23 バクスター、インターナショナル、インコーポレイテッド Method for promoting vascularization of implantable devices
DK1125577T3 (en) * 1994-04-08 2006-06-19 Qlt Usa Inc Liquid drug delivery preparations
US6911216B1 (en) 1994-10-12 2005-06-28 Genzyme Corporation Targeted delivery via biodegradable polymers
US5782789A (en) * 1994-10-19 1998-07-21 Atrium Medical Corporation Macrochannel phosthetic/delivery patch
US5660848A (en) * 1994-11-02 1997-08-26 The Population Council, Center For Biomedical Research Subdermally implantable device
FI954565A0 (en) * 1995-09-27 1995-09-27 Biocon Oy Biologically applied polymeric material to the implant and foil preparation
US5869041A (en) * 1996-01-12 1999-02-09 The Miriam Hospital Delivery of bioactive compounds to an organism
EP0941116B1 (en) * 1996-11-01 2005-01-19 Ark Therapeutics Limited Use of vegf for the manufacture of a medicament for the treatment or prevention of intimal hyperplasia and delivery device
US20080305999A1 (en) * 1996-11-01 2008-12-11 John Francis Martin Therapeutic use of growth factor, and delivery device, especially for the treatment of intimal hyperplasia
US6203813B1 (en) 1997-01-13 2001-03-20 Lance L. Gooberman Pharmaceutical delivery device and method of preparation therefor
EP1089785A1 (en) 1998-06-22 2001-04-11 Neovasys, Inc. Method, implant and delivery system for enhancing blood flow in tissue
US6921412B1 (en) 1999-05-18 2005-07-26 Cryolife, Inc. Self-supporting, shaped, three-dimensional biopolymeric materials and methods
JP2003500174A (en) * 1999-05-27 2003-01-07 フアルマシア・コーポレーシヨン Biomaterials modified with superoxide dismutase mimics
US7039863B1 (en) * 1999-07-23 2006-05-02 Adobe Systems Incorporated Computer generation of documents using layout elements and content elements
US6618698B1 (en) * 1999-08-12 2003-09-09 Quickturn Design Systems, Inc. Clustered processors in an emulation engine
WO2002085284A2 (en) * 2000-11-07 2002-10-31 Cryolife, Inc. Expandable foam-like biomaterials and methods
US8539334B2 (en) 2000-12-27 2013-09-17 Tractmanager, Inc. Document management system having automatic notifications
US10114821B2 (en) * 2000-12-27 2018-10-30 Tractmanager, Inc. Method and system to access to electronic business documents
WO2003002100A1 (en) * 2001-06-26 2003-01-09 Farrell John J Tamper-proof narcotic delivery system
FR2839645B1 (en) * 2002-05-15 2005-08-05 Backert Marie Elisabeth Cuine MULTILAMELLAR SYSTEM FOR THE ADMINISTRATION OF ACTIVE SUBSTANCES (IN PARTICULAR DRUGS) BY ORAL INGESTION
JP2006512693A (en) 2002-12-30 2006-04-13 トムソン コーポレイション A knowledge management system for law firms.
DE10361940A1 (en) * 2003-12-24 2005-07-28 Restate Patent Ag Degradation control of biodegradable implants by coating
US7716206B2 (en) * 2004-11-01 2010-05-11 At&T Intellectual Property I, L.P. Communication networks and methods and computer program products for performing searches thereon while maintaining user privacy
US8234137B2 (en) * 2005-10-03 2012-07-31 Stellar Services One view integrated project management system
US20080059494A1 (en) * 2006-09-01 2008-03-06 Ean Rouse Schuessler Document database system and method
US20080183766A1 (en) * 2007-01-31 2008-07-31 Weston David W Methods and systems for inductive data transformation
US8024315B2 (en) * 2007-07-20 2011-09-20 International Business Machines Corporation Method of dynamically providing a compound object's source information during its development
US8316314B2 (en) 2010-06-30 2012-11-20 Thermo Electron Scientific Instruments Llc Intelligent multi-functional macros language for analytical measurements
US10420923B1 (en) 2010-08-10 2019-09-24 Amiram Katz Method and device for intrathecal administering of immunoglobulin
US10817508B2 (en) * 2010-12-13 2020-10-27 Micro Focus Llc Techniques for constructing and editing a search query using an overload cell
US8551525B2 (en) 2010-12-23 2013-10-08 Biostructures, Llc Bone graft materials and methods
US20150066556A1 (en) * 2013-08-29 2015-03-05 Steve Dominick System and method for an electronic document management and review tool for litigation matters
CN103593447B (en) * 2013-11-18 2017-02-08 北京国双科技有限公司 Data processing method and device applied to database table
US20150363887A1 (en) * 2014-06-11 2015-12-17 Joe Ferri System for tracking and attributing credit accrued through geographically dispersed representation
US9808608B2 (en) * 2014-11-16 2017-11-07 International Business Machines Corporation Helical coil delivery device for active agent
US20180293091A1 (en) * 2015-07-15 2018-10-11 Mitsubishi Electric Corporation Display control apparatus and display control method

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CA1045977A (en) * 1973-05-17 1979-01-09 Arthur D. Little Biodegradable, implantable drug delivery device, and process for preparing and using the same
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US4952403A (en) * 1987-06-19 1990-08-28 President And Fellows Of Harvard College Implants for the promotion of healing of meniscal tissue
EP0528971B1 (en) * 1990-05-14 1999-09-01 JERNBERG, Gary R. Surgical implant and method incorporating chemotherapeutic agents
EP0463194A1 (en) * 1990-06-23 1992-01-02 Boehringer Ingelheim Kg Process for the preparation of poly(D,L-lactide) and its use as a drug carrier
US6178413B1 (en) * 1998-05-20 2001-01-23 Technolines, Llc Database program with automatic creation of user features
US6182069B1 (en) * 1992-11-09 2001-01-30 International Business Machines Corporation Video query system and method
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Also Published As

Publication number Publication date
EP0637946A1 (en) 1995-02-15
US7031960B1 (en) 2006-04-18
USRE43391E1 (en) 2012-05-15
AU4370593A (en) 1993-11-29
US5326568A (en) 1994-07-05
JPH08500088A (en) 1996-01-09
EP0637946A4 (en) 1996-09-11
WO1993021859A1 (en) 1993-11-11
US5494677A (en) 1996-02-27
CA2134680C (en) 2004-11-30

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