CA2136008A1 - Substituted (arylalkylaminobenzyl)amino-propionamide derivatives and process for their preparation - Google Patents
Substituted (arylalkylaminobenzyl)amino-propionamide derivatives and process for their preparationInfo
- Publication number
- CA2136008A1 CA2136008A1 CA002136008A CA2136008A CA2136008A1 CA 2136008 A1 CA2136008 A1 CA 2136008A1 CA 002136008 A CA002136008 A CA 002136008A CA 2136008 A CA2136008 A CA 2136008A CA 2136008 A1 CA2136008 A1 CA 2136008A1
- Authority
- CA
- Canada
- Prior art keywords
- hydrogen
- halogen
- arylalkylaminobenzyl
- amino
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
The invention provides new compounds of formula (I) wherein o is an integer of 1 to 4; each of R and R1, which may be the same or different, is hydrogen, halogen, trifluoromethyl or C1-C4 alkoxy; R2 is hydrogen or C1-C4 alkyl;
and a pharmaceutically acceptable salt thereof;
and wherein when, at the same time, R is hydrogen, R1 is hydrogen or halogen and n is one, then R2 is other than hydrogen or methyl; and of formula (IA) wherein R3 is halogen, and a pharmaceutically acceptable salt thereof, which are active on the central nervous system (CNS) and can be used in therapy as anti-epileptics, anti-Parkinson, neuroprotective, antidepressant, anti-spastic anal hypnotic agents.
and a pharmaceutically acceptable salt thereof;
and wherein when, at the same time, R is hydrogen, R1 is hydrogen or halogen and n is one, then R2 is other than hydrogen or methyl; and of formula (IA) wherein R3 is halogen, and a pharmaceutically acceptable salt thereof, which are active on the central nervous system (CNS) and can be used in therapy as anti-epileptics, anti-Parkinson, neuroprotective, antidepressant, anti-spastic anal hypnotic agents.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939306899A GB9306899D0 (en) | 1993-04-01 | 1993-04-01 | Substituted (arylalkylaminobenzyl) aminopropionamide derivatives and process for their preparation |
GB9306899.7 | 1993-04-01 | ||
PCT/EP1994/000825 WO1994022809A1 (en) | 1993-04-01 | 1994-03-15 | Substituted (arylalkylaminobenzyl)aminopropionamide derivatives, their preparation and use anti-epileptic, neuroprotective and antidepressant agents |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2136008A1 true CA2136008A1 (en) | 1994-10-13 |
CA2136008C CA2136008C (en) | 2005-06-14 |
Family
ID=10733226
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002136008A Expired - Fee Related CA2136008C (en) | 1993-04-01 | 1994-03-15 | Substituted (arylalkylaminobenzyl)amino-propionamide derivatives and process for their preparation |
Country Status (21)
Country | Link |
---|---|
US (1) | US5449692A (en) |
EP (1) | EP0648202B1 (en) |
JP (1) | JP3542600B2 (en) |
KR (1) | KR950701905A (en) |
CN (1) | CN1035939C (en) |
AT (1) | ATE152442T1 (en) |
AU (1) | AU667169B2 (en) |
CA (1) | CA2136008C (en) |
DE (1) | DE69402935T2 (en) |
DK (1) | DK0648202T3 (en) |
ES (1) | ES2104370T3 (en) |
FI (1) | FI945582A (en) |
GB (1) | GB9306899D0 (en) |
GR (1) | GR3024150T3 (en) |
HU (1) | HUT70944A (en) |
IL (1) | IL108970A0 (en) |
NZ (1) | NZ263183A (en) |
PL (1) | PL306538A1 (en) |
RU (1) | RU94046144A (en) |
WO (1) | WO1994022809A1 (en) |
ZA (1) | ZA941964B (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9515412D0 (en) * | 1995-07-27 | 1995-09-27 | Pharmacia Spa | 2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives |
IT1283489B1 (en) * | 1996-07-23 | 1998-04-21 | Chiesi Farma Spa | AMIDES OF ALPHA-AMINO ACIDS, THEIR PREPARATION AND THEIR THERAPEUTIC USE |
ES2402104T3 (en) | 1997-11-21 | 2013-04-29 | Purdue Neuroscience Company | Use of substituted 2-aminoacetamides for the treatment or relief of anxiety |
GB9727523D0 (en) | 1997-12-31 | 1998-02-25 | Pharmacia & Upjohn Spa | Alpha-aminoamide derivatives useful as analgesic agents |
US6281211B1 (en) | 1999-02-04 | 2001-08-28 | Euro-Celtique S.A. | Substituted semicarbazides and the use thereof |
DK1169060T3 (en) * | 1999-04-09 | 2006-01-16 | Euro Celtique Sa | Sodium channel blocker preparations and their use |
PT1423168E (en) | 2001-09-03 | 2006-05-31 | Newron Pharm Spa | PHARMACEUTICAL COMPOSITION WHICH UNDERSTAND GABAPENTINE OR ITS ANALOGUE AND AN X-AMINOAMIDE AND ITS USE AS ANALGESIC |
EP1438956A1 (en) | 2003-01-16 | 2004-07-21 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful as antimigraine agents |
ES2347581T3 (en) * | 2004-09-10 | 2010-11-02 | Newron Pharmaceuticals S.P.A. | USE OF (R) - (HALOBENCILOXI) BENCILAMINE-PROPANAMIDS AS SELECTIVE MODULATORS OF THE SODIUM AND / OR CALCIUM CHANNEL. |
EP1943231A1 (en) * | 2005-10-26 | 2008-07-16 | Boehringer Ingelheim International Gmbh | (hetero)aryl compounds with mch antagonistic activity and medicaments comprising these compounds |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1140748A (en) * | 1966-06-23 | 1969-01-22 | Ici Ltd | New carboxylic acid derivatives |
US4049663A (en) * | 1972-06-06 | 1977-09-20 | Allen & Hanburys Limited | Ethylene diamine derivatives |
DE3050800C2 (en) * | 1979-03-22 | 1989-06-22 | Continental Pharma Inc., Bruessel/Bruxelles, Be | |
FR2480747A1 (en) * | 1980-04-17 | 1981-10-23 | Roques Bernard | AMINO ACID DERIVATIVES AND THEIR THERAPEUTIC APPLICATION |
US4631287A (en) * | 1985-04-16 | 1986-12-23 | Usv Pharmaceutical Corp. | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments |
US4839369A (en) * | 1985-04-16 | 1989-06-13 | Rorer Pharmaceutical Corporation | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments |
US4725619A (en) * | 1985-04-16 | 1988-02-16 | Usv Pharmaceutical Corporation | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments |
US4728668A (en) * | 1985-04-16 | 1988-03-01 | Usv Pharmaceutical Corporation | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments |
IL94466A (en) * | 1989-05-25 | 1995-01-24 | Erba Carlo Spa | Pharmaceutical compositions containing n-phenylalkyl substituted alpha-amino carboxamide derivatives, some such novel compounds and their preparation |
-
1993
- 1993-04-01 GB GB939306899A patent/GB9306899D0/en active Pending
-
1994
- 1994-03-14 IL IL10897094A patent/IL108970A0/en not_active IP Right Cessation
- 1994-03-15 WO PCT/EP1994/000825 patent/WO1994022809A1/en active IP Right Grant
- 1994-03-15 KR KR1019940704344A patent/KR950701905A/en not_active Application Discontinuation
- 1994-03-15 AT AT94911181T patent/ATE152442T1/en not_active IP Right Cessation
- 1994-03-15 NZ NZ263183A patent/NZ263183A/en unknown
- 1994-03-15 DE DE69402935T patent/DE69402935T2/en not_active Expired - Fee Related
- 1994-03-15 DK DK94911181.9T patent/DK0648202T3/en active
- 1994-03-15 PL PL94306538A patent/PL306538A1/en unknown
- 1994-03-15 HU HU9403809A patent/HUT70944A/en unknown
- 1994-03-15 AU AU63776/94A patent/AU667169B2/en not_active Ceased
- 1994-03-15 CA CA002136008A patent/CA2136008C/en not_active Expired - Fee Related
- 1994-03-15 EP EP94911181A patent/EP0648202B1/en not_active Expired - Lifetime
- 1994-03-15 CN CN94190169A patent/CN1035939C/en not_active Expired - Fee Related
- 1994-03-15 ES ES94911181T patent/ES2104370T3/en not_active Expired - Lifetime
- 1994-03-15 JP JP52143094A patent/JP3542600B2/en not_active Expired - Fee Related
- 1994-03-15 RU RU94046144/04A patent/RU94046144A/en unknown
- 1994-03-21 ZA ZA941964A patent/ZA941964B/en unknown
- 1994-03-22 US US08/215,694 patent/US5449692A/en not_active Expired - Lifetime
- 1994-11-28 FI FI945582A patent/FI945582A/en unknown
-
1997
- 1997-07-16 GR GR970401800T patent/GR3024150T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO1994022809A1 (en) | 1994-10-13 |
CA2136008C (en) | 2005-06-14 |
GR3024150T3 (en) | 1997-10-31 |
FI945582A0 (en) | 1994-11-28 |
KR950701905A (en) | 1995-05-17 |
CN1104018A (en) | 1995-06-21 |
AU6377694A (en) | 1994-10-24 |
IL108970A0 (en) | 1994-06-24 |
HUT70944A (en) | 1995-11-28 |
JPH08504828A (en) | 1996-05-28 |
GB9306899D0 (en) | 1993-05-26 |
ES2104370T3 (en) | 1997-10-01 |
US5449692A (en) | 1995-09-12 |
RU94046144A (en) | 1996-09-27 |
AU667169B2 (en) | 1996-03-07 |
DE69402935T2 (en) | 1997-11-20 |
NZ263183A (en) | 1996-02-27 |
EP0648202B1 (en) | 1997-05-02 |
ZA941964B (en) | 1994-10-19 |
PL306538A1 (en) | 1995-04-03 |
HU9403809D0 (en) | 1995-02-28 |
CN1035939C (en) | 1997-09-24 |
ATE152442T1 (en) | 1997-05-15 |
DK0648202T3 (en) | 1997-10-27 |
FI945582A (en) | 1994-11-28 |
DE69402935D1 (en) | 1997-06-05 |
JP3542600B2 (en) | 2004-07-14 |
EP0648202A1 (en) | 1995-04-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |