CA2140903A1 - Biosensor for hematocrit determination - Google Patents

Biosensor for hematocrit determination

Info

Publication number
CA2140903A1
CA2140903A1 CA002140903A CA2140903A CA2140903A1 CA 2140903 A1 CA2140903 A1 CA 2140903A1 CA 002140903 A CA002140903 A CA 002140903A CA 2140903 A CA2140903 A CA 2140903A CA 2140903 A1 CA2140903 A1 CA 2140903A1
Authority
CA
Canada
Prior art keywords
biosensor
electrodes
electroactive compound
current
blood sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002140903A
Other languages
French (fr)
Other versions
CA2140903C (en
Inventor
Lance S. Kuhn
Mary Luann Ochs
Gilbert C. Morris
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics Operations Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2140903A1 publication Critical patent/CA2140903A1/en
Application granted granted Critical
Publication of CA2140903C publication Critical patent/CA2140903C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood

Abstract

A biosensor (1) and method for determining the hematocrit level of a whole blood sample (11) using electrochemistry. The biosensor (1) includes working (4) and counter (5) electrodes. A porous membrane (9) is impregnated with an electroactive compound and is spatially displaced from the surface of the electrodes (4, 5). When a whole blood sample (11) is applied to the porous substrate (9), a mixture of the electroactive compound and the blood (11) is formed. The mixture settles on the electrodes (4, 5) and a potential difference is applied sufficient to oxidize or reduce the electroactive compound and generate a current. This current can be measured and correlated to hematocrit level.
CA002140903A 1993-06-03 1994-06-03 Biosensor for hematocrit determination Expired - Fee Related CA2140903C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/072,198 1993-06-03
US08/072,198 US5385846A (en) 1993-06-03 1993-06-03 Biosensor and method for hematocrit determination
PCT/US1994/006237 WO1994029731A1 (en) 1993-06-03 1994-06-03 Biosensor for hematocrit determination

Publications (2)

Publication Number Publication Date
CA2140903A1 true CA2140903A1 (en) 1994-12-04
CA2140903C CA2140903C (en) 2003-01-14

Family

ID=22106176

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002140903A Expired - Fee Related CA2140903C (en) 1993-06-03 1994-06-03 Biosensor for hematocrit determination

Country Status (7)

Country Link
US (1) US5385846A (en)
EP (1) EP0653068B1 (en)
JP (1) JP3369183B2 (en)
CA (1) CA2140903C (en)
DE (1) DE69422687T2 (en)
ES (1) ES2142946T3 (en)
WO (1) WO1994029731A1 (en)

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EP0653068B1 (en) 2000-01-19
EP0653068A4 (en) 1995-11-02
DE69422687T2 (en) 2000-06-29
CA2140903C (en) 2003-01-14
DE69422687D1 (en) 2000-02-24
ES2142946T3 (en) 2000-05-01
EP0653068A1 (en) 1995-05-17
JPH08500190A (en) 1996-01-09
JP3369183B2 (en) 2003-01-20
WO1994029731A1 (en) 1994-12-22
US5385846A (en) 1995-01-31

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