CA2145631A1 - Two-phase matrix for sustained release drug delivery device - Google Patents

Two-phase matrix for sustained release drug delivery device

Info

Publication number
CA2145631A1
CA2145631A1 CA002145631A CA2145631A CA2145631A1 CA 2145631 A1 CA2145631 A1 CA 2145631A1 CA 002145631 A CA002145631 A CA 002145631A CA 2145631 A CA2145631 A CA 2145631A CA 2145631 A1 CA2145631 A1 CA 2145631A1
Authority
CA
Canada
Prior art keywords
phase
drug delivery
delivery device
sustained release
release drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002145631A
Other languages
French (fr)
Other versions
CA2145631C (en
Inventor
Tsung-Min Hsu
Tung Fen Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceuticals Inc
Original Assignee
Tsung-Min Hsu
Tung Fen Chen
Cygnus Therapeutic Systems
Cygnus, Inc.
Ortho-Mcneil Pharmaceutical, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tsung-Min Hsu, Tung Fen Chen, Cygnus Therapeutic Systems, Cygnus, Inc., Ortho-Mcneil Pharmaceutical, Inc. filed Critical Tsung-Min Hsu
Publication of CA2145631A1 publication Critical patent/CA2145631A1/en
Application granted granted Critical
Publication of CA2145631C publication Critical patent/CA2145631C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide

Abstract

A two-phase hydrophilic drug-containing matrix for use in transdermal drug delivery patches (10) in which one phase is a continuous hydrophobic polymer phase which optionally includes a hydrophobic solvent that acts as a skin permeation enhancer and the other phase is a dispersed particulate hydrated inorganic silicate in whose absorbed aqueous phase the drug is dissolved.
A simple transdermal patch structure (10) contains a backing layer (11), a matrix layer (12) and a release liner layer (13) as com-ponents.
CA002145631A 1992-10-05 1993-10-05 Two-phase matrix for sustained release drug delivery device Expired - Lifetime CA2145631C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US95663592A 1992-10-05 1992-10-05
US07/956,635 1992-10-05
US08/056,076 US5989586A (en) 1992-10-05 1993-04-30 Two-phase matrix for sustained release drug delivery device
US08/056,076 1993-04-30
PCT/US1993/009510 WO1994007468A1 (en) 1992-10-05 1993-10-05 Two-phase matrix for sustained release drug delivery device

Publications (2)

Publication Number Publication Date
CA2145631A1 true CA2145631A1 (en) 1994-04-14
CA2145631C CA2145631C (en) 2004-02-10

Family

ID=26734946

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002145631A Expired - Lifetime CA2145631C (en) 1992-10-05 1993-10-05 Two-phase matrix for sustained release drug delivery device

Country Status (14)

Country Link
US (2) US5989586A (en)
EP (1) EP0662822B1 (en)
JP (1) JPH08504757A (en)
CN (1) CN1089469A (en)
AT (1) ATE198420T1 (en)
AU (1) AU5321194A (en)
CA (1) CA2145631C (en)
DE (1) DE69329825T2 (en)
DK (1) DK0662822T3 (en)
ES (1) ES2155073T3 (en)
GR (1) GR3035626T3 (en)
PT (1) PT662822E (en)
TW (1) TW252919B (en)
WO (1) WO1994007468A1 (en)

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GR3035626T3 (en) 2001-06-29
DE69329825D1 (en) 2001-02-08
JPH08504757A (en) 1996-05-21
AU5321194A (en) 1994-04-26
ES2155073T3 (en) 2001-05-01
ATE198420T1 (en) 2001-01-15
DK0662822T3 (en) 2001-01-29
WO1994007468A1 (en) 1994-04-14
PT662822E (en) 2001-04-30
DE69329825T2 (en) 2001-06-13
EP0662822A4 (en) 1996-08-07
EP0662822B1 (en) 2001-01-03
EP0662822A1 (en) 1995-07-19
CN1089469A (en) 1994-07-20
TW252919B (en) 1995-08-01
CA2145631C (en) 2004-02-10
US5989586A (en) 1999-11-23
US5840336A (en) 1998-11-24

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