CA2153391A1 - Inducing Cytotoxic T Lymphocyte Responses - Google Patents

Inducing Cytotoxic T Lymphocyte Responses

Info

Publication number
CA2153391A1
CA2153391A1 CA2153391A CA2153391A CA2153391A1 CA 2153391 A1 CA2153391 A1 CA 2153391A1 CA 2153391 A CA2153391 A CA 2153391A CA 2153391 A CA2153391 A CA 2153391A CA 2153391 A1 CA2153391 A1 CA 2153391A1
Authority
CA
Canada
Prior art keywords
particulate
replicating
protein antigen
protein
mammalian host
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2153391A
Other languages
French (fr)
Other versions
CA2153391C (en
Inventor
Kenneth Rock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dana Farber Cancer Institute Inc
Original Assignee
Kenneth Rock
Dana-Farber Cancer Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kenneth Rock, Dana-Farber Cancer Institute filed Critical Kenneth Rock
Publication of CA2153391A1 publication Critical patent/CA2153391A1/en
Application granted granted Critical
Publication of CA2153391C publication Critical patent/CA2153391C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/70Nanostructure
    • Y10S977/788Of specified organic or carbon-based composition
    • Y10S977/802Virus-based particle
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/70Nanostructure
    • Y10S977/788Of specified organic or carbon-based composition
    • Y10S977/802Virus-based particle
    • Y10S977/803Containing biological material in its interior
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915Therapeutic or pharmaceutical composition
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915Therapeutic or pharmaceutical composition
    • Y10S977/917Vaccine
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/918Immunological
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/92Detection of biochemical

Abstract

The invention provides compositions and methods for inducing MHC class I-restricted cytotoxic T lymphocyte responses in a mammalian host by immunization with non-replicating protein antigens. The compositions of the invention comprise a particulate-protein complex capable of inducing a class I-restricted CTL response to a protein antigen in a mammal in which the particulate protein complex comprises a particulate component having an average diameter ranging in size from about .5µm to about 6µm linked to a non-replicating protein antigen derived from a tumor cell or from pathogenic organism where CTL response is likely to play an important role in conferring protective immunity in a mammal, with the proviso that the particulate component is not a prokaryotic or eukaryotic cell, or a micellar, multimicellar, or liposome vesicle composed of detergents or lipids. The non-replicating protein antigen is attached to the particle component through a covalent or non-covalent association to form particulate protein antigen complexes and the complexes are administered to a mammalian host in conjunction with a pharmaceutically acceptable excipient, in a CTL-stimulatory amount. The invention also provides non-replicating vaccines and methods of vaccinating a mammalian host against pathogenic diseases or tumors for CTL immunity.
CA002153391A 1993-01-11 1994-01-10 Inducing cytotoxic t lymphocyte responses Expired - Lifetime CA2153391C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US323393A 1993-01-11 1993-01-11
US08/003,233 1993-01-11
PCT/US1994/000362 WO1994015635A1 (en) 1993-01-11 1994-01-10 Inducing cytotoxic t lymphocyte responses

Publications (2)

Publication Number Publication Date
CA2153391A1 true CA2153391A1 (en) 1994-07-21
CA2153391C CA2153391C (en) 2000-08-15

Family

ID=21704843

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002153391A Expired - Lifetime CA2153391C (en) 1993-01-11 1994-01-10 Inducing cytotoxic t lymphocyte responses

Country Status (11)

Country Link
US (2) US5928647A (en)
EP (1) EP0678034B1 (en)
JP (1) JPH08505625A (en)
AT (1) ATE180407T1 (en)
AU (1) AU679041B2 (en)
CA (1) CA2153391C (en)
DE (1) DE69418699T2 (en)
DK (1) DK0678034T3 (en)
ES (1) ES2131676T3 (en)
GR (1) GR3030568T3 (en)
WO (1) WO1994015635A1 (en)

Families Citing this family (132)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1217395A (en) * 1993-12-23 1995-07-10 GFF Gesellschaft zur Forderung der industrie-orientierten Forschung Immunological response potentiation process
JP3365635B2 (en) * 1994-09-23 2003-01-14 ゾナジェン,インコーポレイテッド Chitosan-induced immune enhancement
US6030613A (en) * 1995-01-17 2000-02-29 The Brigham And Women's Hospital, Inc. Receptor specific transepithelial transport of therapeutics
ES2268182T3 (en) * 1995-01-17 2007-03-16 The Brigham And Women's Hospital, Inc. SPECIFIC TRANSEPITELIAL TRANSPORTATION OF IMMUNOGEN RECEIVERS.
US6485726B1 (en) 1995-01-17 2002-11-26 The Brigham And Women's Hospital, Inc. Receptor specific transepithelial transport of therapeutics
US6086875A (en) * 1995-01-17 2000-07-11 The Brigham And Women's Hospital, Inc. Receptor specific transepithelial transport of immunogens
DE19511276C2 (en) * 1995-03-27 1999-02-18 Immuno Ag Adjuvant based on colloidal iron compounds
US6458366B1 (en) 1995-09-01 2002-10-01 Corixa Corporation Compounds and methods for diagnosis of tuberculosis
US6592877B1 (en) * 1995-09-01 2003-07-15 Corixa Corporation Compounds and methods for immunotherapy and diagnosis of tuberculosis
US6290969B1 (en) * 1995-09-01 2001-09-18 Corixa Corporation Compounds and methods for immunotherapy and diagnosis of tuberculosis
US20050003431A1 (en) * 1996-08-16 2005-01-06 Wucherpfennig Kai W. Monovalent, multivalent, and multimeric MHC binding domain fusion proteins and conjugates, and uses therefor
EP1275380A1 (en) * 1997-01-30 2003-01-15 Chiron Corporation Use of microparticles with adsorbed antigen to stimulate immune responses
ATE235890T1 (en) * 1997-01-30 2003-04-15 Chiron Corp USE OF MICROPARTICLES WITH ADSORBED ANTIGEN TO STIMULATE IMMUNE DEFENSE
US6884435B1 (en) 1997-01-30 2005-04-26 Chiron Corporation Microparticles with adsorbent surfaces, methods of making same, and uses thereof
US7087713B2 (en) * 2000-02-25 2006-08-08 Corixa Corporation Compounds and methods for diagnosis and immunotherapy of tuberculosis
US20060165606A1 (en) * 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6254890B1 (en) * 1997-12-12 2001-07-03 Massachusetts Institute Of Technology Sub-100nm biodegradable polymer spheres capable of transporting and releasing nucleic acids
US20020147143A1 (en) 1998-03-18 2002-10-10 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
US20030235557A1 (en) 1998-09-30 2003-12-25 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
US8143386B2 (en) * 1999-04-07 2012-03-27 Corixa Corporation Fusion proteins of mycobacterium tuberculosis antigens and their uses
JP2003510370A (en) * 1999-10-07 2003-03-18 コリクサ コーポレイション Fusion protein of Mycobacterium tuberculosis
AU7877900A (en) * 1999-10-13 2001-04-23 Chiron Corporation Method of obtaining cellular immune responses from proteins
AU2001256156B2 (en) 2000-02-23 2006-01-05 Smithkline Beecham Biologicals S.A. Novel compounds
US20040002068A1 (en) 2000-03-01 2004-01-01 Corixa Corporation Compositions and methods for the detection, diagnosis and therapy of hematological malignancies
US20010036463A1 (en) * 2000-03-09 2001-11-01 Compans Richard W. Transcutaneous immunization for large particulate antigens
CA2407897A1 (en) 2000-05-05 2001-11-15 Cytos Biotechnology Ag Molecular antigen arrays and vaccines
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
MXPA02001323A (en) 2000-05-10 2004-07-16 Alliance Pharma Phospholipid-based powders for drug delivery.
ATE526994T1 (en) 2000-06-20 2011-10-15 Corixa Corp MTB32A ANTIGEN FROM MYCOBACTERIA TUBERCULOSIS WITH INACTIVATED PROTEASE ACTIVITY AND FUSION PROTEINS THAT CONTAIN THE ANTIGEN
AR029540A1 (en) 2000-06-28 2003-07-02 Corixa Corp COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND THERAPY OF CA NCER DE PULMoN
WO2002009674A2 (en) * 2000-07-28 2002-02-07 Inhale Therapeutic Systems, Inc. Methods and compositions to upregulate, redirect or limit immune responses to bioactive compounds
AUPR011700A0 (en) * 2000-09-14 2000-10-05 Austin Research Institute, The Composition comprising immunogenic virus sized particles (VSP)
WO2002026212A2 (en) * 2000-09-28 2002-04-04 Chiron Corporation Microparticle compositions and methods for the manufacture thereof
CN1468089B (en) * 2000-09-28 2011-09-21 诺华疫苗和诊断公司 Microparticles for delivery of the heterologous nucleic acids
US7264810B2 (en) * 2001-01-19 2007-09-04 Cytos Biotechnology Ag Molecular antigen array
US7618939B2 (en) 2001-02-15 2009-11-17 The Board Of Trustees Of The University Of Illinois Compositions and methods to prevent cancer with cupredoxins
US7491394B2 (en) 2001-02-15 2009-02-17 The Board Of Trustees Of The University Of Illinois Cytotoxic factors for modulating cell death
US20040126900A1 (en) * 2001-04-13 2004-07-01 Barry Stephen E High affinity peptide- containing nanoparticles
JP2005504513A (en) 2001-05-09 2005-02-17 コリクサ コーポレイション Compositions and methods for treatment and diagnosis of prostate cancer
CA2452382A1 (en) 2001-07-10 2003-01-23 Corixa Corporation Compositions and methods for delivery of proteins and adjuvants encapsulated in microspheres
ES2405405T3 (en) 2001-12-17 2013-05-31 Corixa Corporation Compositions and procedures for the therapy and diagnosis of inflammatory bowel disease
US20030219459A1 (en) * 2002-01-18 2003-11-27 Cytos Biotechnology Ag Prion protein carrier-conjugates
US7026465B2 (en) 2002-02-15 2006-04-11 Corixa Corporation Fusion proteins of Mycobacterium tuberculosis
CA2478973A1 (en) * 2002-03-13 2003-09-25 Kirin Beer Kabushiki Kaisha Human monoclonal antibodies to influenza m2 protein and methods of making and using same
US20040170606A1 (en) * 2002-06-07 2004-09-02 Palmer Kenneth E. Production of peptides in plants as viral coat protein fusions
US20040033585A1 (en) * 2002-06-07 2004-02-19 Mccormick Alison A. Flexible vaccine assembly and vaccine delivery platform
BR0311995A (en) * 2002-06-20 2005-04-05 Cytos Biotechnology Ag Virus-like particles packaged for use as adjuvants: Method of preparation and use
CN1668637B (en) * 2002-07-17 2010-05-26 希托斯生物技术股份公司 Molecular antigen arrays using a virus like particle derived from the AP205 coat protein
JP5084103B2 (en) * 2002-07-18 2012-11-28 サイトス バイオテクノロジー アーゲー Hapten carrier conjugates and uses thereof
MXPA05000819A (en) * 2002-07-19 2005-08-29 Cytos Biotechnology Ag Vaccine compositions containing amyloid beta1-6 antigen arrays.
WO2004100984A1 (en) * 2003-05-13 2004-11-25 The University Of Massachusetts Endogenous adjuvant molecules and uses thereof
ES2328697T5 (en) 2003-06-02 2017-07-25 Novartis Vaccines And Diagnostics, Inc. Immunogenic compositions based on microparticles comprising adsorbed toxoid and an antigen containing a polysaccharide
CN1835974A (en) 2003-06-16 2006-09-20 细胞技术研究与发展公司 Antibodies specific for sclerostin and methods for increasing bone mineralization
US9050352B2 (en) * 2003-10-16 2015-06-09 Stephen John Ralph Immunomodulating compositions and uses therefor
ZA200604663B (en) * 2004-01-20 2008-02-27 Cytos Biotechnology Ag Particle-induced ghrelin immune response
WO2006031264A2 (en) 2004-05-25 2006-03-23 Oregon Health And Science University Siv and hiv vaccination using rhcmv- and hcmv-based vaccine vectors
BRPI0516775A (en) * 2004-10-25 2008-09-23 Cytos Biotechnology Ag gastric inhibitor antigen (gip) polypeptide assays and their uses
WO2007001448A2 (en) 2004-11-04 2007-01-04 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
GB0424563D0 (en) 2004-11-05 2004-12-08 Novartis Ag Organic compounds
AU2006229968A1 (en) 2005-03-31 2006-10-05 Corixa Corporation Vaccines against Chlamydial infection
KR20150036658A (en) 2005-04-29 2015-04-07 글락소스미스클라인 바이오로지칼즈 에스.에이. Novel method for preventing or treating m tuberculosis infection
US9216212B2 (en) 2005-08-05 2015-12-22 University Of Massachusetts Virus-like particles as vaccines for paramyxovirus
US7951384B2 (en) * 2005-08-05 2011-05-31 University Of Massachusetts Virus-like particles as vaccines for paramyxovirus
US9267937B2 (en) 2005-12-15 2016-02-23 Massachusetts Institute Of Technology System for screening particles
CA2648099C (en) 2006-03-31 2012-05-29 The Brigham And Women's Hospital, Inc System for targeted delivery of therapeutic agents
US8524454B2 (en) 2006-04-07 2013-09-03 The Research Foundation Of State University Of New York Transcobalamin receptor polypeptides, nucleic acids, and modulators thereof, and related methods of use in modulating cell growth and treating cancer and cobalamin deficiency
US7702468B2 (en) 2006-05-03 2010-04-20 Population Diagnostics, Inc. Evaluating genetic disorders
US10522240B2 (en) 2006-05-03 2019-12-31 Population Bio, Inc. Evaluating genetic disorders
US8367113B2 (en) 2006-05-15 2013-02-05 Massachusetts Institute Of Technology Polymers for functional particles
WO2007150030A2 (en) * 2006-06-23 2007-12-27 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
WO2008019142A2 (en) * 2006-08-04 2008-02-14 Massachusetts Institute Of Technology Oligonucleotide systems for targeted intracellular delivery
WO2008098165A2 (en) 2007-02-09 2008-08-14 Massachusetts Institute Of Technology Oscillating cell culture bioreactor
JP5391387B2 (en) * 2007-03-09 2014-01-15 小川 一文 Magnetosensitive drug and method for producing the same
WO2008124639A2 (en) * 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Poly (amino acid) targeting moieties
US8932558B2 (en) * 2007-10-05 2015-01-13 Plaxgen Inc Multi-subunit biological complexes for treatment of plaque-associated diseases
AU2008314647B2 (en) 2007-10-12 2013-03-21 Massachusetts Institute Of Technology Vaccine nanotechnology
US8268887B2 (en) 2008-10-08 2012-09-18 Feng Xu Drug conjugates and methods of use thereof
US8277812B2 (en) 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
US8591905B2 (en) 2008-10-12 2013-11-26 The Brigham And Women's Hospital, Inc. Nicotine immunonanotherapeutics
US8343498B2 (en) 2008-10-12 2013-01-01 Massachusetts Institute Of Technology Adjuvant incorporation in immunonanotherapeutics
US8343497B2 (en) 2008-10-12 2013-01-01 The Brigham And Women's Hospital, Inc. Targeting of antigen presenting cells with immunonanotherapeutics
EA201791383A1 (en) 2009-05-27 2018-06-29 Селекта Байосайенсиз, Инк. NANOSEELS HAVE COMPONENTS WITH DIFFERENT RELEASE RATES
US20110038852A1 (en) * 2009-06-10 2011-02-17 3-V Biosciences, Inc. Antivirals that target transporters, carriers, and ion channels
CN107617110A (en) * 2009-08-26 2018-01-23 西莱克塔生物科技公司 The composition of inducing T cell auxiliary
US20120244185A1 (en) 2009-09-16 2012-09-27 Vaxart ,Inc. Immunization strategy to prevent h1n1 infection
KR20170098985A (en) 2009-11-19 2017-08-30 솔리스 바이오다인 Compositions for increasing polypeptide stability and activity, and related methods
DK2528621T3 (en) 2010-01-27 2017-01-02 Glaxosmithkline Biologicals Sa Modified tuberculosis antigens
NO2575876T3 (en) 2010-05-26 2018-05-05
US8862410B2 (en) 2010-08-02 2014-10-14 Population Diagnostics, Inc. Compositions and methods for discovery of causative mutations in genetic disorders
EP2640190A4 (en) 2010-11-05 2016-05-11 Selecta Biosciences Inc Modified nicotinic compounds and related methods
EP2683244B1 (en) 2011-03-08 2017-02-01 3-V Biosciences, Inc. Heterocyclic modulators of lipid synthesis
EA201791679A1 (en) 2011-04-29 2018-09-28 Селекта Байосайенсиз, Инк. TOLEROGENIC SYNTHETIC NANO CARRIERS
US20150030586A1 (en) 2011-06-21 2015-01-29 Sarah Ellen Warren Compositions and methods for the therapy and diagnosis of cancer
EP2736537A4 (en) 2011-07-29 2015-04-15 Selecta Biosciences Inc Synthetic nanocarriers that generate humoral and cytotoxic t lymphocyte (ctl) immune responses
US10221454B2 (en) 2011-10-10 2019-03-05 The Hospital For Sick Children Methods and compositions for screening and treating developmental disorders
WO2013067451A2 (en) 2011-11-04 2013-05-10 Population Diagnostics Inc. Methods and compositions for diagnosing, prognosing, and treating neurological conditions
CN107880101B (en) 2011-11-11 2021-12-21 弗雷德哈钦森癌症研究中心 T cell immunotherapy targeting cyclin A1 against cancer
WO2013120018A1 (en) 2012-02-09 2013-08-15 Population Diagnostics, Inc. Methods and compositions for screening and treating developmental disorders
BR112014021388A2 (en) 2012-02-29 2017-07-18 Ethicon Endo Surgery Inc microbiota compositions and methods related thereto
WO2014043519A1 (en) 2012-09-14 2014-03-20 Population Diagnostics Inc. Methods and compositions for diagnosing, prognosing, and treating neurological conditions
EP2900835A4 (en) 2012-09-27 2016-05-11 Population Diagnotics Inc Methods and compositions for screening and treating developmental disorders
GB2535034A (en) 2013-07-21 2016-08-10 Whole Biome Inc Methods and systems for microbiome characterization, monitoring and treatment
JP6820097B2 (en) 2013-12-20 2021-01-27 サギメット バイオサイエンシーズ インコーポレイテッド Heterocyclic modulators of lipid synthesis and their combinations
MX2016008841A (en) 2014-01-07 2016-10-13 3-V Biosciences Inc Heterocyclic modulators of lipid synthesis for use against cancer and viral infections.
CN113403338A (en) 2014-03-28 2021-09-17 华盛顿大学商业中心 Breast and ovarian cancer vaccines
EP3169699A4 (en) 2014-07-18 2018-06-20 The University of Washington Cancer vaccine compositions and methods of use thereof
US10724096B2 (en) 2014-09-05 2020-07-28 Population Bio, Inc. Methods and compositions for inhibiting and treating neurological conditions
WO2016054240A1 (en) 2014-09-30 2016-04-07 Sean Dalziel Fixed dose combinations for the treatment of viral diseases
CN113730442A (en) 2014-10-31 2021-12-03 潘德勒姆治疗公司 Methods and compositions relating to microbial treatment and diagnosis of disorders
JP6758314B2 (en) 2015-03-19 2020-09-23 サギメット バイオサイエンシーズ インコーポレイテッド Heterocyclic regulator of lipid synthesis
JP6912394B2 (en) 2015-06-12 2021-08-04 バクサート インコーポレイテッド Formulations for small intestinal delivery of RSV and norovirus antigens
CN109415445A (en) 2016-05-04 2019-03-01 阿比利塔生物公司 It is used to prepare the method and platform of membrane-spanning proteins
US10294454B2 (en) 2016-08-24 2019-05-21 General Electric Company Methods and kits for cell activation
US11725232B2 (en) 2016-10-31 2023-08-15 The Hong Kong University Of Science And Technology Compositions, methods and kits for detection of genetic variants for alzheimer's disease
US10240205B2 (en) 2017-02-03 2019-03-26 Population Bio, Inc. Methods for assessing risk of developing a viral disease using a genetic test
GB201710973D0 (en) 2017-07-07 2017-08-23 Avacta Life Sciences Ltd Scaffold proteins
CA3073838A1 (en) 2017-08-30 2019-03-07 Pendulum Therapeutics, Inc. Methods and compositions for treatment of microbiome-associated disorders
MX2020013772A (en) 2018-06-29 2021-05-27 Wuhan Neurophth Biotechnology Ltd Company Compositions and methods for treating leber's hereditary optic neuropathy.
FI3625368T3 (en) 2018-08-08 2023-01-13 Methods for assessing the risk of developing progressive multifocal leukoencephalopathy caused by john cunningham virus by genetic testing
CA3109432A1 (en) 2018-08-20 2020-02-27 Wuhan Neurophth Biotechnology Limited Company Compositions and methods for treating leber's hereditary optic neuropathy
JP7320601B2 (en) 2018-09-11 2023-08-03 上▲海▼市公共▲衛▼生▲臨▼床中心 Broad-spectrum anti-influenza vaccine immunogen and its use
TW202120551A (en) 2019-08-12 2021-06-01 美商普瑞諾生物科技公司 Methods and compositions for promoting and potentiating t‐cell mediated immune responses through adcc targeting of cd39 expressing cells
WO2021074695A1 (en) 2019-10-16 2021-04-22 Avacta Life Sciences Limited PD-L1 INHIBITOR - TGFβ INHIBITOR BISPECIFIC DRUG MOIETIES.
CN113025633A (en) 2019-12-09 2021-06-25 武汉纽福斯生物科技有限公司 Nucleic acid for coding human NADH dehydrogenase subunit 1 protein and application thereof
GB202101299D0 (en) 2020-06-09 2021-03-17 Avacta Life Sciences Ltd Diagnostic polypetides and methods
WO2022234003A1 (en) 2021-05-07 2022-11-10 Avacta Life Sciences Limited Cd33 binding polypeptides with stefin a protein
WO2023280157A1 (en) 2021-07-05 2023-01-12 武汉纽福斯生物科技有限公司 Construction and use of anti-vegf antibody in-vivo expression system
TW202332694A (en) 2021-10-07 2023-08-16 英商阿凡克塔生命科學公司 Serum half-life extended pd-l1 binding polypeptides
TW202334196A (en) 2021-10-07 2023-09-01 英商阿法克塔生命科學有限公司 Pd-l1 binding polypeptides
WO2023218243A1 (en) 2022-05-12 2023-11-16 Avacta Life Sciences Limited Lag-3/pd-l1 binding fusion proteins

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK143689C (en) * 1975-03-20 1982-03-15 J Kreuter PROCEDURE FOR THE PREPARATION OF AN ADVERTISED VACCINE
US4804624A (en) * 1982-05-21 1989-02-14 The University Of Tennessee Research Corporation Passive agglutination assay for pseudorabies antibody
US5417986A (en) * 1984-03-16 1995-05-23 The United States Of America As Represented By The Secretary Of The Army Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres
GB2160312B (en) 1984-04-13 1987-09-16 South African Inventions Adjuvant for immunisation
US5078998A (en) 1985-08-02 1992-01-07 Bevan Michael J Hybrid ligand directed to activation of cytotoxic effector T lymphocytes and target associated antigen
GB8610983D0 (en) 1986-05-06 1986-06-11 Connaught Lab Enhancement of antigen immunogenicity
US5194254A (en) 1986-05-06 1993-03-16 Connaught Laboratories Limited Enhancement of antigen immunogenicity
US5041385A (en) 1986-11-01 1991-08-20 Oxford Gene Systems Limited Vector expressing fusion proteins and particles
US4918166A (en) 1987-04-10 1990-04-17 Oxford Gene Systems Limited Particulate hybrid HIV antigens
US5008116A (en) 1988-11-14 1991-04-16 Frederick Cahn Immunostimulatory microsphere
WO1990007322A1 (en) 1988-12-19 1990-07-12 David Gordon Diagnosis and treatment of viral effects
US5021551A (en) 1989-01-18 1991-06-04 Washington University Method of enhancing peptide immunogenicity
US5045320A (en) * 1989-03-23 1991-09-03 Medical Biology Institute Large multivalent immunogen
ES2096650T3 (en) * 1990-05-10 1997-03-16 Dana Farber Cancer Inst Inc IMPROVEMENT OF THE ASSOCIATION OF EXOGENOUS PEPTIDES WITH MHC CLASS I MOLECULES IN CELLS OF THE IMMUNE SYSTEM.
US5219577A (en) 1990-06-22 1993-06-15 The Regents Of The University Of California Biologically active composition having a nanocrystalline core
WO1992019263A1 (en) 1991-04-24 1992-11-12 The United States Of America, As Represented By The Secretary Of The Army Oral-intestinal vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres
WO1992021376A1 (en) 1991-06-06 1992-12-10 Med Immune, Inc. Induction of ctl responses to foreign antigens expressed in mycobacteria
FR2682114B1 (en) * 1991-10-03 1996-02-23 Pasteur Merieux Serums Vacc SUB-UNIT VACCINE AGAINST NEISSERIA MENINGITIDIS AND SUB-UNITS CORRESPONDING TO PURIFIED STATE.
ATE212540T1 (en) 1991-11-26 2002-02-15 Jenner Technologies ANTITUMOR VACCINES

Also Published As

Publication number Publication date
GR3030568T3 (en) 1999-10-29
WO1994015635A1 (en) 1994-07-21
DK0678034T3 (en) 1999-11-08
EP0678034A1 (en) 1995-10-25
AU6086594A (en) 1994-08-15
US6328972B1 (en) 2001-12-11
DE69418699T2 (en) 1999-09-30
EP0678034B1 (en) 1999-05-26
CA2153391C (en) 2000-08-15
ES2131676T3 (en) 1999-08-01
DE69418699D1 (en) 1999-07-01
ATE180407T1 (en) 1999-06-15
US5928647A (en) 1999-07-27
JPH08505625A (en) 1996-06-18
AU679041B2 (en) 1997-06-19

Similar Documents

Publication Publication Date Title
CA2153391A1 (en) Inducing Cytotoxic T Lymphocyte Responses
Hunter et al. Production of gamma interferon by natural killer cells from Toxoplasma gondii-infected SCID mice: regulation by interleukin-10, interleukin-12, and tumor necrosis factor alpha
US6726910B2 (en) Immuno-reactive peptide CTL epitopes of human cytomegalovirus
CA2123580A1 (en) Antigen of hybrid m protein and carrier for group a streptococcal vaccine
CA2033640A1 (en) Vaccines against cancer and infectious diseases
CA2143823A1 (en) Retro-, inverso - and retro-inverso synthetic peptide analogues
ES8406199A1 (en) Materials and methods for herpes simplex virus vaccination.
CA2232344A1 (en) Compositions and methods for enhancing immune responses mediated by antigen-presenting cells
CA2014033A1 (en) Compositions and treatments for pneumonia in animals
CA2140624A1 (en) P53 vaccine
CA2055615A1 (en) Monoclonal antibodies for inducing tolerance
Salabert et al. Intradermal injection of an anti‐Langerin‐HIVGag fusion vaccine targets epidermal Langerhans cells in nonhuman primates and can be tracked in vivo
CA2372181A1 (en) Adjuvant combination formulations
Grufman et al. Innate and adaptive immunity to tumors: IL‐12 is required for optimal responses
JP4666761B2 (en) Immunomodulators for vaccines
Chiarantini et al. Red blood cells as delivery system for recombinant HSV-1 glycoprotein B: immunogenicity and protection in mice
Unanue et al. Role of macrophages in delayed hypersensitivity: I. Induction with macrophage-bound antigen
FI932759A0 (en) Enhancement of IL-4 For the purpose of vaccinia immunogenic generic immunoreaction
EP0427768A1 (en) Polypeptide pertussis toxin vaccine
CA2399432A1 (en) Cytotoxic t lymphocytes activated by dendritic cell hybrids
US4622223A (en) Broad spectrum vaccine against gonorrhea
Hatzifoti et al. Liposomal co-entrapment of CD40mAb induces enhanced IgG responses against bacterial polysaccharide and protein
Allison Antigens and adjuvants for a new generation of vaccines
Knittel et al. Heparan sulfates targeting increases MHC class I-and MHC class II-restricted antigen presentation and CD8+ T-cell response
EP0783892B1 (en) Method to increase and modify immune responses

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20140110