CA2154469A1 - Structured copolymers and their uses as absorbents, gels and carriers of metal ions - Google Patents

Structured copolymers and their uses as absorbents, gels and carriers of metal ions

Info

Publication number
CA2154469A1
CA2154469A1 CA002154469A CA2154469A CA2154469A1 CA 2154469 A1 CA2154469 A1 CA 2154469A1 CA 002154469 A CA002154469 A CA 002154469A CA 2154469 A CA2154469 A CA 2154469A CA 2154469 A1 CA2154469 A1 CA 2154469A1
Authority
CA
Canada
Prior art keywords
metal ions
modified
gels
absorbents
carriers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002154469A
Other languages
French (fr)
Other versions
CA2154469C (en
Inventor
David M. Hedstrand
Donald A. Tomalia
Bradley J. Helmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dendritic Nanotechnologies Inc
Original Assignee
David M. Hedstrand
Donald A. Tomalia
Bradley J. Helmer
The Dow Chemical Company
Avc Holdings Inc.
Dendritic Nanotechnologies, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by David M. Hedstrand, Donald A. Tomalia, Bradley J. Helmer, The Dow Chemical Company, Avc Holdings Inc., Dendritic Nanotechnologies, Inc. filed Critical David M. Hedstrand
Publication of CA2154469A1 publication Critical patent/CA2154469A1/en
Application granted granted Critical
Publication of CA2154469C publication Critical patent/CA2154469C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002—Dendritic macromolecules
    • C08G83/003—Dendrimers
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
    • A01N25/10—Macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/595—Polyamides, e.g. nylon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
    • C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0206—Polyalkylene(poly)amines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/024—Polyamines containing oxygen in the form of ether bonds in the main chain
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/028—Polyamidoamines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L101/00—Compositions of unspecified macromolecular compounds
    • C08L101/005—Dendritic macromolecules
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L79/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing nitrogen with or without oxygen or carbon only, not provided for in groups C08L61/00 - C08L77/00
    • C08L79/02—Polyamines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L25/00—Compositions of, homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an aromatic carbocyclic ring; Compositions of derivatives of such polymers
    • C08L25/02—Homopolymers or copolymers of hydrocarbons
    • C08L25/04—Homopolymers or copolymers of styrene
    • C08L25/06—Polystyrene

Abstract

Dense star polymers or dendrimers having a highly branched interior structure capable of associating or chelating with metal ions are modified by capping with a hydrophobic group capable of providing a hydrophobic outer shell. The modified dendrimers are useful for dispersing metal ions in a non-aqueous polymer matrix. Also dense star polymers or dendrimers having a highly branched hydrophilic interior structure are modified by capping with a hydrophobic group capable of providing a hydrophobic outer shell, which modified polymers are useful as gels and surfactants.
CA002154469A 1993-01-22 1994-01-21 Structured copolymers and their uses as absorbents, gels and carriers of metal ions Expired - Fee Related CA2154469C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US827593A 1993-01-22 1993-01-22
US08/152,335 US5560929A (en) 1986-08-18 1993-11-12 Structured copolymers and their use as absorbents, gels and carriers of metal ions
US152,335 1993-11-12
US008,275 1993-11-12
PCT/US1994/000801 WO1994017125A1 (en) 1993-01-22 1994-01-21 Structured copolymers used as absorbents, gels and carriers of metal ions

Publications (2)

Publication Number Publication Date
CA2154469A1 true CA2154469A1 (en) 1994-08-04
CA2154469C CA2154469C (en) 2004-10-05

Family

ID=26678019

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002154469A Expired - Fee Related CA2154469C (en) 1993-01-22 1994-01-21 Structured copolymers and their uses as absorbents, gels and carriers of metal ions

Country Status (14)

Country Link
US (1) US5560929A (en)
EP (1) EP0680495B1 (en)
JP (1) JPH08505899A (en)
KR (1) KR100295923B1 (en)
CN (2) CN1038842C (en)
AT (1) ATE221905T1 (en)
AU (1) AU683875B2 (en)
CA (1) CA2154469C (en)
CZ (1) CZ291389B6 (en)
DE (1) DE69431150T2 (en)
FI (1) FI109910B (en)
HU (1) HU220996B1 (en)
TW (1) TW337531B (en)
WO (1) WO1994017125A1 (en)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3938992A1 (en) * 1989-11-21 1991-05-23 Schering Ag Cascade polymer-bound complex formers, their complexes and conjugates, process for their preparation and pharmaceutical compositions containing them
US5795587A (en) 1995-01-23 1998-08-18 University Of Pittsburgh Stable lipid-comprising drug delivery complexes and methods for their production
US20030069173A1 (en) * 1998-03-16 2003-04-10 Life Technologies, Inc. Peptide-enhanced transfections
US6051429A (en) * 1995-06-07 2000-04-18 Life Technologies, Inc. Peptide-enhanced cationic lipid transfections
US5658574A (en) * 1995-10-13 1997-08-19 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Cleansing compositions with dendrimers as mildness agents
NL1001753C2 (en) * 1995-11-28 1997-05-30 Dsm Nv Composition comprising a plastic and an additive.
JP4233117B2 (en) * 1997-01-13 2009-03-04 住友化学株式会社 Dendritic polymer nanocomposites
US5739218A (en) * 1997-06-02 1998-04-14 Dow Corning Corporation Radially layered copoly (amidoamine-organosilicon) dendrimers
WO1998056427A1 (en) * 1997-06-12 1998-12-17 Mitsubishi Chemical Corporation Novel contrast media
US6545101B2 (en) 1997-06-25 2003-04-08 Exxonmobil Chemical Patents Inc. Star-branched polymer with dendrimer core
WO1998058970A1 (en) * 1997-06-25 1998-12-30 Exxon Chemical Patents Inc. Star-branched polymer with dendrimer core
US6228978B1 (en) 1997-06-25 2001-05-08 Exxon Mobil Chemical Patents Inc Star-branched polymer with dendrimer core
US5902863A (en) * 1997-07-21 1999-05-11 Dow Corning Corporation Dendrimer-based networks containing lyophilic organosilicon and hydrophilic polyamidoamine nanoscopic domains
US6056805A (en) * 1997-08-15 2000-05-02 Guardian Environmental Technologies, Inc. Method and apparatus for the absorption of non-polar organic molecules on hydrocarbon block copolymers
US6252014B1 (en) 1998-08-04 2001-06-26 Colorado School Of Mines Star polymers and polymeric particles in the nanometer-sized range by step growth reactions
EP1129064B1 (en) 1998-11-12 2008-01-09 Invitrogen Corporation Transfection reagents
US6258896B1 (en) * 1998-12-18 2001-07-10 3M Innovative Properties Company Dendritic polymer dispersants for hydrophobic particles in water-based systems
FR2790642A1 (en) * 1999-03-08 2000-09-15 Aventis Cropscience Sa NEW PESTICIDE AND / OR REGULATORY GROWTH COMPOSITIONS
US6077500A (en) * 1999-03-18 2000-06-20 Dow Corning Corporation High generation radially layered dendrimers
WO2000064977A1 (en) * 1999-04-26 2000-11-02 California Institute Of Technology In situ forming hydrogels
US6858229B1 (en) 1999-04-26 2005-02-22 California Institute Of Technology In situ forming hydrogels
FR2797563A1 (en) * 1999-08-18 2001-02-23 Rhodianyl BIOCIDAL COMPOUNDS AND THEIR USE IN THERMOPLASTIC POLYMERS
JP3181276B2 (en) 1999-08-31 2001-07-03 科学技術振興事業団 Amphiphilic compounds with dendritic branch structure
US20040146918A1 (en) * 2000-02-18 2004-07-29 Weiner Michael L. Hybrid nucleic acid assembly
US6471968B1 (en) 2000-05-12 2002-10-29 Regents Of The University Of Michigan Multifunctional nanodevice platform
US6350384B1 (en) 2000-08-14 2002-02-26 Dow Corning Corporation Silicon containing multi-arm star polymers
FR2814164B1 (en) * 2000-09-18 2002-11-22 Rhodia Chimie Sa CEMENT MATERIAL COMPRISING A DENDRITIC POLYMER
US6350819B1 (en) 2000-10-27 2002-02-26 Union Carbide Chemicals & Plastics Technology Corporation Dendritic macromolecules for metal-ligand catalyzed processes
KR100413532B1 (en) * 2001-02-14 2003-12-31 학교법인 포항공과대학교 Polyamine terminated dendrimers and preparing method thereof
US6673205B2 (en) * 2001-05-10 2004-01-06 Fort James Corporation Use of hydrophobically modified polyaminamides with polyethylene glycol esters in paper products
US20050019267A1 (en) * 2001-06-25 2005-01-27 Brechbiel Martin W Macromolecular imaging agents for liver imaging
JP3984541B2 (en) * 2001-12-26 2007-10-03 財団法人川村理化学研究所 Particles comprising star-shaped polyoxazoline and method for producing the same
GB0209022D0 (en) * 2002-04-19 2002-05-29 Imp College Innovations Ltd Compounds
US7412121B2 (en) * 2002-10-24 2008-08-12 Applied Research And Photonics, Inc. Nanophotonic integrated circuit and fabrication thereof
US7001580B2 (en) * 2002-12-31 2006-02-21 3M Innovative Properties Company Emulsions including surface-modified organic molecules
WO2005031304A2 (en) 2003-09-22 2005-04-07 Becton, Dickinson And Company Quantification of analytes using internal standards
EP1696974B1 (en) * 2003-12-19 2007-05-23 Basf Aktiengesellschaft Swellable hydrogel-forming polymers having a low fine dust concentration
US20050171424A1 (en) * 2004-01-13 2005-08-04 The Gov. Of The Usa As Rep. By The Secretary Of The Dept. Of Health And Human Services Methods for imaging the lymphatic system using dendrimer-based contrast agents
DE102004015686A1 (en) * 2004-03-29 2005-10-27 Basf Ag Swellable hydrogel-forming polymers with high permeability
ATE432723T1 (en) * 2004-03-29 2009-06-15 Procter & Gamble ABSORBENT ELEMENT FOR ABSORBENT ARTICLES CONTAINING HIGH PERMEABILITY HYDROGEL-FORMING, SWELLABLE POLYMERS
EP1766061B1 (en) * 2004-05-20 2013-07-17 Quest Diagnostics Investments Incorporated Single label comparative hybridization
US20050276862A1 (en) * 2004-06-15 2005-12-15 Bringley Joseph F Iron sequestering antimicrobial composition
US7323109B2 (en) * 2004-06-15 2008-01-29 Eastman Kodak Company Composition comprising metal-ion sequestrant
US7723285B2 (en) * 2004-07-20 2010-05-25 Michigan Molecular Institute Beneficial agent delivery systems
RU2371165C2 (en) 2004-08-17 2009-10-27 Унилевер Нв Hair care composition including macromolecules with dendrite structure
BRPI0514368B1 (en) * 2004-08-17 2015-08-11 Unilever Nv Method to decrease hair volume and use of a hydrophobically functionalized dendritic macromolecule
US20090104119A1 (en) * 2004-08-25 2009-04-23 Majoros Istvan J Dendrimer Based Compositions And Methods Of Using The Same
US20070041934A1 (en) * 2005-08-12 2007-02-22 Regents Of The University Of Michigan Dendrimer based compositions and methods of using the same
US8076074B2 (en) 2005-11-29 2011-12-13 Quest Diagnostics Investments Incorporated Balanced translocation in comparative hybridization
US8460879B2 (en) 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US7914588B2 (en) * 2007-04-10 2011-03-29 Los Alamos National Security, Llc Synthesis of fluorescent metal nanoclusters
US20090088376A1 (en) * 2007-04-19 2009-04-02 The Regents Of The University Of Michigan Dendrimer based compositions and methods of using the same
JP5446119B2 (en) * 2007-05-08 2014-03-19 公立大学法人大阪府立大学 Polyamidoamine dendron lipids containing lower acyl groups
US7507539B2 (en) * 2007-07-30 2009-03-24 Quest Diagnostics Investments Incorporated Substractive single label comparative hybridization
WO2009151687A2 (en) 2008-03-12 2009-12-17 The Regents Of The University Of Michigan Dendrimer conjugates
WO2010039861A2 (en) 2008-09-30 2010-04-08 The Regents Of The University Of Michigan Dendrimer conjugates
WO2010054321A2 (en) 2008-11-07 2010-05-14 The Regents Of The University Of Michigan Methods of treating autoimmune disorders and/or inflammatory disorders
WO2011059609A2 (en) 2009-10-13 2011-05-19 The Regents Of The University Of Michigan Dendrimer compositions and methods of synthesis
WO2011059586A2 (en) 2009-10-30 2011-05-19 The Regents Of The University Of Michigan Multifunctional small molecules
KR102007997B1 (en) 2011-02-07 2019-08-07 라이프 테크놀로지스 코포레이션 Compositions and methods for stabilizing susceptible compounds
US9402911B2 (en) 2011-12-08 2016-08-02 The Regents Of The University Of Michigan Multifunctional small molecules
US9603953B2 (en) 2014-01-13 2017-03-28 Guanghua YANG Dendrimer compositions, methods of synthesis, and uses thereof
EP3169310A1 (en) 2014-07-15 2017-05-24 Life Technologies Corporation Compositions with lipid aggregates and methods for efficient delivery of molecules to cells
CN111542471A (en) 2017-08-21 2020-08-14 劲锋铁马股份有限公司 Bicycle cone pulley with clamping connection
CN108840807B (en) * 2018-08-23 2019-07-05 东北石油大学 Bluish violet fluorophor and preparation method thereof
CN109433718A (en) * 2018-10-25 2019-03-08 湖北金洋资源股份公司 A kind of cleaning process of metalwork containing greasy dirt

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US469064A (en) * 1892-02-16 Tooth-pick case
US3200106A (en) * 1960-08-04 1965-08-10 Petrolite Corp Derivatives of branched polyalkylene-polyamines
US3514250A (en) * 1965-03-25 1970-05-26 Petrolite Corp Process of inhibiting corrosion
US3445441A (en) * 1965-03-25 1969-05-20 Petrolite Corp Amino-amido polymers
US3580891A (en) * 1968-04-16 1971-05-25 Seekay Chemical Co Water-insoluble,cross-linked polymeric reaction product of ethylene diamine and nitrilotriacetic acid or derivative
US3528928A (en) * 1969-01-13 1970-09-15 Petrolite Corp Process of breaking oil-in-water emulsions
US3578643A (en) * 1969-06-06 1971-05-11 Grace W R & Co New polymers from nitrilotriacetonitrile and iminodiacetonitrile
BE756896A (en) * 1969-10-01 1971-03-30 Montedison Spa BASIC POLYAMIDES, THEIR METHODS OF PREPARATION AND THEIR APPLICATIONS
US4036808A (en) * 1972-08-14 1977-07-19 California Institute Of Technology Conductive hydrogel containing 3-ionene
US4102827A (en) * 1973-12-26 1978-07-25 California Institute Of Technology Novel polyelectrolytes
US4315087A (en) * 1975-04-28 1982-02-09 Petrolite Corporation Quaternary polyaminoamides
US4141847A (en) * 1977-05-11 1979-02-27 Shell Oil Company Star-shaped polymer reacted with dicarboxylic acid and amine as dispersant viscosity index improver
US4360646A (en) * 1979-04-06 1982-11-23 Allied Corporation Preparation of lysine based macromolecular highly branched homogeneous compound
US4289872A (en) * 1979-04-06 1981-09-15 Allied Corporation Macromolecular highly branched homogeneous compound based on lysine units
US4435548A (en) * 1981-04-27 1984-03-06 The Dow Chemical Company Branched polyamidoamines
US4410688A (en) * 1981-04-29 1983-10-18 Allied Corporation Macromolecular highly branched homogeneous compound
US4957939A (en) * 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
US4472509A (en) * 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
US4737550A (en) * 1983-01-07 1988-04-12 The Dow Chemical Company Bridged dense star polymers
US4631337A (en) * 1983-01-07 1986-12-23 The Dow Chemical Company Hydrolytically-stable dense star polyamine
US4558120A (en) * 1983-01-07 1985-12-10 The Dow Chemical Company Dense star polymer
US4507466A (en) * 1983-01-07 1985-03-26 The Dow Chemical Corporation Dense star polymers having core, core branches, terminal groups
US4568737A (en) * 1983-01-07 1986-02-04 The Dow Chemical Company Dense star polymers and dendrimers
US4855403A (en) * 1983-02-22 1989-08-08 Union Carbide Corporation Connected branch copolymers, methods for their production, and copying materials including same
US4946824A (en) * 1983-02-22 1990-08-07 Union Carbide Chemicals And Plastics Company Inc. Connected branch copolymers, methods for their production, and copying materials including same
US4634586A (en) * 1984-05-21 1987-01-06 The Board Of Trustees Of The Leland Stanford Junior University Reagent and method for radioimaging leukocytes
US4606907A (en) * 1984-07-02 1986-08-19 The Dow Chemical Company Bone seeking Tc-99m complexes of phosphonate derivatives of polyamidoamines
US4587329A (en) * 1984-08-17 1986-05-06 The Dow Chemical Company Dense star polymers having two dimensional molecular diameter
US4857218A (en) * 1984-08-17 1989-08-15 Union Carbide Corporation Lubrication method and compositions for use therein
US4980148A (en) * 1985-02-06 1990-12-25 Mallinckrodt, Inc. Methods for enhancing magnetic resonance imaging
US4675173A (en) * 1985-05-08 1987-06-23 Molecular Biosystems, Inc. Method of magnetic resonance imaging of the liver and spleen
US4824659A (en) * 1985-06-07 1989-04-25 Immunomedics, Inc. Antibody conjugates
US4871779A (en) * 1985-12-23 1989-10-03 The Dow Chemical Company Ion exchange/chelation resins containing dense star polymers having ion exchange or chelate capabilities
IT1213029B (en) * 1986-01-30 1989-12-07 Bracco Ind Chimica Spa PARAMAGNETIC METAL ION CHELATES.
US4694064A (en) * 1986-02-28 1987-09-15 The Dow Chemical Company Rod-shaped dendrimer
US4713975A (en) * 1986-05-30 1987-12-22 The Dow Chemical Company Dense star polymers for calibrating/characterizing sub-micron apertures
US5039512A (en) * 1986-08-04 1991-08-13 Salutar, Inc. NMR imaging with paramagnetic polyvalent metal salts of poly-(acid-alkylene-amino)-alkanes
IL83567A (en) * 1986-08-18 1992-02-16 Dow Chemical Co Starburst conjugates with a carried material,such as an agricultural or pharmaceutical material
US5175270A (en) * 1986-09-10 1992-12-29 Polyprobe, Inc. Reagents for detecting and assaying nucleic acid sequences
US4863717A (en) * 1986-11-10 1989-09-05 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Methods for circumventing the problem of free radial reduction associated with the use of stable nitroxide free radicals as contrast agents for magnetic reasonance imaging
JPS6484336A (en) * 1987-09-26 1989-03-29 Toshiba Corp Restriction directing type inference device
US4857599A (en) * 1988-02-08 1989-08-15 The Dow Chemical Company Modified dense star polymers
US5364613A (en) * 1989-04-07 1994-11-15 Sieving Paul F Polychelants containing macrocyclic chelant moieties
AU5649290A (en) * 1989-04-12 1990-11-05 New York University Dendritic polymer of multiple antigen peptide system useful as anti-malarial vaccine
US5041516A (en) * 1989-06-21 1991-08-20 Cornell Research Foundation, Inc. Dendritic molecules and method of production
US4938885A (en) * 1989-09-28 1990-07-03 Texaco Inc. Antioxidant dispersant polymer dendrimer
DE3938992A1 (en) * 1989-11-21 1991-05-23 Schering Ag Cascade polymer-bound complex formers, their complexes and conjugates, process for their preparation and pharmaceutical compositions containing them
MY108621A (en) * 1990-08-01 1996-10-31 Novartis Ag Polylactide preparation and purification
US5098475A (en) * 1991-01-28 1992-03-24 Xerox Corporation Inks with dendrimer colorants
US5154853A (en) * 1991-02-19 1992-10-13 University Of South Florida Unimolecular micelles and method of making the same
US5120361A (en) * 1991-06-27 1992-06-09 Xerox Corporation Ink compositions
DE69209231T2 (en) * 1991-11-07 1996-08-22 Shell Int Research Secondary amines and a process for their preparation
CA2105967C (en) * 1992-01-13 2003-05-20 Egbert W. Meijer Dendritic macromolecule and the preparation thereof

Also Published As

Publication number Publication date
FI953530A (en) 1995-07-21
CZ291389B6 (en) 2003-02-12
US5560929A (en) 1996-10-01
CN1038842C (en) 1998-06-24
KR100295923B1 (en) 2001-10-24
AU683875B2 (en) 1997-11-27
EP0680495B1 (en) 2002-08-07
WO1994017125A1 (en) 1994-08-04
HUT73151A (en) 1996-06-28
EP0680495A1 (en) 1995-11-08
FI109910B (en) 2002-10-31
AU6231694A (en) 1994-08-15
TW337531B (en) 1998-08-01
CZ190595A3 (en) 1995-12-13
DE69431150T2 (en) 2003-05-22
CA2154469C (en) 2004-10-05
HU9502024D0 (en) 1995-09-28
ATE221905T1 (en) 2002-08-15
CN1089775C (en) 2002-08-28
FI953530A0 (en) 1995-07-21
JPH08505899A (en) 1996-06-25
HU220996B1 (en) 2002-07-29
KR960700292A (en) 1996-01-19
CN1174852A (en) 1998-03-04
DE69431150D1 (en) 2002-09-12
CN1118168A (en) 1996-03-06

Similar Documents

Publication Publication Date Title
CA2154469A1 (en) Structured copolymers and their uses as absorbents, gels and carriers of metal ions
HUT72727A (en) Small cell foams and process for preparation thereof and blends
EP0620256A3 (en) Polymer composition for hydrophilic treatment.
EP0631337A3 (en) Solid polymer electrolyte composition.
CA2234036A1 (en) Multi-core, multi-cover golf ball
CA2122251A1 (en) Wettable silicone hydrogel compositions and methods for their manufacture
CA2198247A1 (en) Ionene polymers containing biologically-active anions
CA2152258A1 (en) Novel Macromonomers
CA2159055A1 (en) Compositions containing polyanionic polysaccharides and hydrophobic bioabsorbable polymers
CA2304934A1 (en) Moisture-absorbing and desorbing polymer and compositions derived therefrom
TW226380B (en)
WO1994024187A3 (en) Organosilicon-containing materials useful for biomedical devices
EP0718325A3 (en) Process for preparing ethylene-alpha-olefin-nonconjugated polyene random copolymer, copolymer obtained thereby, and uses of the copolymer
CA2142576A1 (en) Antiperspirant Deodorant Compositions
CA2183308A1 (en) A sealing and venting component for an apparatus which generates an internal gas
TR28980A (en) Hydrophilic polymer composition and the product containing it.
ZA965537B (en) High strength, fast absorbing, melt processable, glycoliderich, poly(glycolide-CO-p-dioxanone) copolymers.
CA2144281A1 (en) Method of Preparing Microcapsules
CA2191872A1 (en) Beta sheet forming peptides and gels made thereof
AU5312098A (en) Polymer bottle closed by crown cap or such like
CA2133955A1 (en) Polyetheramidoamine hydrogels as heparinizable materials
CA2336914A1 (en) Polymer supports containing polyoxyalkylenes
AU2387895A (en) Polymeric electrolyte formed from alkane monomers
EP0739912A3 (en) Polymer with high acid value, uses therefor, and process for producing the same
CA2369825A1 (en) Microstructured components

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed