CA2154867A1 - Gas mixtures useful as ultrasound contrast media - Google Patents

Gas mixtures useful as ultrasound contrast media

Info

Publication number
CA2154867A1
CA2154867A1 CA002154867A CA2154867A CA2154867A1 CA 2154867 A1 CA2154867 A1 CA 2154867A1 CA 002154867 A CA002154867 A CA 002154867A CA 2154867 A CA2154867 A CA 2154867A CA 2154867 A1 CA2154867 A1 CA 2154867A1
Authority
CA
Canada
Prior art keywords
ultrasound contrast
ultrasound
mixture
component
gas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002154867A
Other languages
French (fr)
Other versions
CA2154867C (en
Inventor
Feng Yan
Michel Schneider
Jean Brochot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Suisse SA
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2154867A1 publication Critical patent/CA2154867A1/en
Application granted granted Critical
Publication of CA2154867C publication Critical patent/CA2154867C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/225—Microparticles, microcapsules

Abstract

The invention relates to injectable media for ultrasonic echography in the form of microbubbles or microballons comprising at least two biocompatible substances A and B (gaseous at the body temperature) forming a mixture which when in suspension with usual surfactants, additives and stabilisers provides useful ultrasound contrast agents. At least one of the components (B) in the mixture is a gas whose molecular weight is greater than 80 daltons and whose solubility in water is below 0.0283ml per ml of water at standard conditions.
The presence of the first component (B) in the contrast medium may vary between 0.5 and 41 volume percent. The other component (A) of the ultrasound contrast media is a gas or a mixture of gases whose molecular weight is below 80 daltons. The second component is present in a proportion of between 59-99.5 % by vol., and is preferably chosen from oxygen, air, nitrogen, carbon dioxide or mixtures thereof. Gas mixtures described are found to be very effective as ultrasound contrast media. The invention also comprises a method of making the ultrasound contrast medium, the contrast agent and the ultrasound agent kit.
CA002154867A 1993-12-15 1994-12-01 Gas mixtures useful as ultrasound contrast media Expired - Fee Related CA2154867C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP93810885.9 1993-12-15
EP93810885 1993-12-15
PCT/IB1994/000376 WO1995016467A1 (en) 1993-12-15 1994-12-01 Gas mixtures useful as ultrasound contrast media

Publications (2)

Publication Number Publication Date
CA2154867A1 true CA2154867A1 (en) 1995-06-22
CA2154867C CA2154867C (en) 2007-05-29

Family

ID=8215090

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002154867A Expired - Fee Related CA2154867C (en) 1993-12-15 1994-12-01 Gas mixtures useful as ultrasound contrast media

Country Status (23)

Country Link
US (3) US5846518A (en)
EP (1) EP0682530B1 (en)
JP (1) JPH10508284A (en)
KR (1) KR100295173B1 (en)
CN (1) CN1068229C (en)
AT (1) ATE234638T1 (en)
AU (1) AU679295B2 (en)
CA (1) CA2154867C (en)
CZ (1) CZ208995A3 (en)
DE (1) DE69432295T2 (en)
DK (1) DK0682530T3 (en)
ES (1) ES2192572T3 (en)
FI (1) FI116365B (en)
HU (1) HU225495B1 (en)
IL (1) IL111977A (en)
IS (1) IS1739B (en)
NO (2) NO314019B1 (en)
NZ (1) NZ276167A (en)
PL (1) PL182223B1 (en)
PT (1) PT682530E (en)
RU (1) RU2138293C1 (en)
WO (1) WO1995016467A1 (en)
ZA (1) ZA949983B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9427396B2 (en) 2008-06-27 2016-08-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010024638A1 (en) * 1992-11-02 2001-09-27 Michel Schneider Stable microbubble suspensions as enhancement agents for ultrasound echography and dry formulations thereof
US20030194376A1 (en) * 1990-05-18 2003-10-16 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
DK0711179T3 (en) 1993-07-30 2005-02-14 Imcor Pharmaceutical Co Stabilized ultrasound microbubble compositions
WO1996040288A1 (en) * 1995-06-07 1996-12-19 Mallinckrodt Medical, Inc. Gaseous ultrasound contrast agents and method therefor
US5804162A (en) 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
US5840276A (en) * 1996-01-11 1998-11-24 Apfel Enterprises, Inc. Activatable infusable dispersions containing drops of a superheated liquid for methods of therapy and diagnosis
DE19602930A1 (en) * 1996-01-18 1997-07-24 Schering Ag Porous matrices made of low molecular weight substances for the generation of stable gas bubble suspensions, their use as ultrasound contrast agents and processes for their production
GB9617811D0 (en) 1996-08-27 1996-10-09 Nycomed Imaging As Improvements in or relating to contrast agents
US5846517A (en) † 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
GB9708240D0 (en) 1997-04-23 1997-06-11 Nycomed Imaging As Improvements in or relating to contrast agents
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
KR20010088022A (en) * 2000-03-10 2001-09-26 모리스 토파즈 Biocompatible, injectable aqueous solution for use in ultrasound energy assisted surgery
EP2279757A3 (en) 2000-06-02 2011-08-03 Bracco Suisse SA Compounds for targeting endothelial cells
US6673334B1 (en) * 2000-10-16 2004-01-06 Mallinkcrodt, Inc. Light sensitive compounds for instant determination of organ function
AU2002253454A1 (en) 2001-04-06 2002-10-21 Bracco Research S.A. Method for improved measurement of local physical parameters in afluid-filled cavity
DE10119522A1 (en) * 2001-04-20 2002-12-05 Innovacell Biotechnologie Gmbh Preparation and application of a suspension composition with an ultrasound contrast medium
WO2004069153A2 (en) * 2003-01-27 2004-08-19 Medrad, Inc. Apparatus, system and method for generating bubbles on demand
EP1587944A4 (en) 2002-03-01 2007-03-21 Dyax Corp Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
US7794693B2 (en) * 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
JP2006514915A (en) 2002-03-01 2006-05-18 ダイアックス、コープ KDR and VEGF / KDR binding peptides and their use in diagnosis and therapy
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7462366B2 (en) 2002-03-29 2008-12-09 Boston Scientific Scimed, Inc. Drug delivery particle
CA2492339A1 (en) 2002-06-12 2003-12-24 Boston Scientific Limited Bulking agents
WO2004006964A1 (en) * 2002-07-11 2004-01-22 Targeson, Llc Microbubble compositions, and methods for preparing and using same
US7842377B2 (en) 2003-08-08 2010-11-30 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US8012454B2 (en) 2002-08-30 2011-09-06 Boston Scientific Scimed, Inc. Embolization
US7883490B2 (en) 2002-10-23 2011-02-08 Boston Scientific Scimed, Inc. Mixing and delivery of therapeutic compositions
EP1572001A1 (en) 2002-11-29 2005-09-14 Amersham Health AS Ultrasound triggering method
KR101076053B1 (en) * 2003-02-04 2011-10-21 브라코 인터내셔날 비.브이. Ultrasound contrast agents and process for the preparation thereof
US20070128117A1 (en) * 2003-02-04 2007-06-07 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
SI2949658T1 (en) 2003-03-03 2018-10-30 Dyax Corp. Peptides that specifically bind HGF receptor (cMet) and uses thereof
ITFI20030077A1 (en) * 2003-03-26 2004-09-27 Actis Active Sensors S R L METHOD FOR THE ECOGRAPHICAL SURVEY THROUGH CONTRAST MEANS
US8021303B2 (en) 2003-06-12 2011-09-20 Bracco Research Sa System for extracting morphological information through a perfusion assessment process
JP4706003B2 (en) 2003-06-12 2011-06-22 ブラッコ・シュイス・ソシエテ・アノニム Blood flow evaluation method using supplemental curve fitting in ultrasound contrast images
JP2007522085A (en) * 2003-06-27 2007-08-09 スミスクライン・ビーチャム・コーポレイション Stabilized topotecan liposome compositions and methods
US7976823B2 (en) 2003-08-29 2011-07-12 Boston Scientific Scimed, Inc. Ferromagnetic particles and methods
EP1701745B1 (en) * 2003-12-22 2014-12-10 Bracco Suisse S.A. Gas-filled microvesicle assembly for contrast imaging
US7736671B2 (en) 2004-03-02 2010-06-15 Boston Scientific Scimed, Inc. Embolization
US8173176B2 (en) 2004-03-30 2012-05-08 Boston Scientific Scimed, Inc. Embolization
US7311861B2 (en) 2004-06-01 2007-12-25 Boston Scientific Scimed, Inc. Embolization
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
AU2004320514B8 (en) * 2004-06-04 2009-08-27 Acusphere, Inc. Ultrasound contrast agent dosage formulation
CN102600485B (en) * 2004-06-04 2014-10-22 阿库斯菲尔公司 Ultrasonic contrast medium dosage formula
CA2575677C (en) 2004-08-18 2013-01-22 Bracco Research Sa Gas-filled microvesicles composition for contrast imaging
US8425550B2 (en) 2004-12-01 2013-04-23 Boston Scientific Scimed, Inc. Embolic coils
CN100556368C (en) 2004-12-23 2009-11-04 伯拉考开发股份有限公司 Perfusion assessment method and system based on bolus injection
US7727555B2 (en) 2005-03-02 2010-06-01 Boston Scientific Scimed, Inc. Particles
US7858183B2 (en) 2005-03-02 2010-12-28 Boston Scientific Scimed, Inc. Particles
WO2006094951A1 (en) * 2005-03-03 2006-09-14 Bracco Research Sa Medical imaging system based on a targeted contrast agent
US7963287B2 (en) 2005-04-28 2011-06-21 Boston Scientific Scimed, Inc. Tissue-treatment methods
US9463426B2 (en) 2005-06-24 2016-10-11 Boston Scientific Scimed, Inc. Methods and systems for coating particles
US8007509B2 (en) 2005-10-12 2011-08-30 Boston Scientific Scimed, Inc. Coil assemblies, components and methods
US8257338B2 (en) 2006-10-27 2012-09-04 Artenga, Inc. Medical microbubble generation
US8634608B2 (en) 2005-11-10 2014-01-21 Bracco Suisse S.A. Instantaneous visualization of contrast agent concentration in imaging applications
US9198639B2 (en) 2005-11-10 2015-12-01 Bracco Suisse S.A. Detection of immobilized contrast agent in medical imaging applications based on flow dynamics analysis
CA2631716C (en) 2005-12-09 2013-11-26 Bracco International B.V. Targeting vector-phospholipid conjugates
EP1797919A1 (en) 2005-12-16 2007-06-20 Bracco Research S.A. Liquid transfer device for medical dispensing containers
US8101197B2 (en) 2005-12-19 2012-01-24 Stryker Corporation Forming coils
US8152839B2 (en) 2005-12-19 2012-04-10 Boston Scientific Scimed, Inc. Embolic coils
US7947368B2 (en) 2005-12-21 2011-05-24 Boston Scientific Scimed, Inc. Block copolymer particles
JP2010506129A (en) * 2006-10-03 2010-02-25 ワイス エルエルシー Freeze drying method and equipment
US8414927B2 (en) 2006-11-03 2013-04-09 Boston Scientific Scimed, Inc. Cross-linked polymer particles
US8512249B2 (en) 2006-12-21 2013-08-20 Bracco International Bv Detection of the detachment of immobilized contrast agent in medical imaging applications
EP2200652B1 (en) 2007-09-27 2018-03-21 Children's Medical Center Corporation Microbubbles and methods for oxygen delivery
WO2009083557A1 (en) 2007-12-28 2009-07-09 Bracco Research S.A. Quantification analisys of immobilized contrast agent in medical imaging applications
US10130342B2 (en) 2007-12-28 2018-11-20 Bracco Suisse Sa Initialization of fitting parameters for perfusion assessment based on bolus administration
EP2189112A1 (en) 2008-11-24 2010-05-26 Bracco Research S.A. Real-time perfusion imaging and quantification
CN102460506B (en) 2009-06-08 2017-07-21 博莱科瑞士股份有限公司 The auto-scaling of parametric image
US8929634B2 (en) 2009-09-01 2015-01-06 Bracco Suisse Sa Parametric images based on dynamic behavior over time
EP2544593B1 (en) 2010-03-09 2014-12-31 Bracco Suisse SA Initialization of fitting parameters for perfusion assessment based on bolus administration
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
US10357450B2 (en) 2012-04-06 2019-07-23 Children's Medical Center Corporation Process for forming microbubbles with high oxygen content and uses thereof
KR101419137B1 (en) * 2012-12-20 2014-07-14 가톨릭대학교 산학협력단 Gas forming drug carrier for drug delivery and preparation method thereof
EP2936433B1 (en) 2012-12-21 2018-09-19 Bracco Suisse SA Segmentation in diagnostic imaging applications based on statistical analysis over time
WO2014144364A1 (en) 2013-03-15 2014-09-18 Children's Medical Center Corporation Gas-filled stabilized particles and methods of use
CN103212094B (en) * 2013-04-28 2014-10-22 重庆医科大学附属儿童医院 Oxygen-fluorine liposome microbubble and preparation method thereof
US10368842B2 (en) 2014-04-07 2019-08-06 Bracco Suisse S.A. Estimation of acoustic level in-situ with non-fundamental analysis
TWI556837B (en) * 2014-07-18 2016-11-11 國立清華大學 Nano/micro bubbles for drug delivery
MX2017008721A (en) 2014-12-31 2017-11-17 Lantheus Medical Imaging Inc Lipid-encapsulated gas microsphere compositions and related methods.
CN108289654B (en) 2015-12-10 2021-03-30 博莱科瑞士股份有限公司 Detection of immobilized contrast agents by dynamic thresholding
CN107233583B (en) * 2016-03-29 2020-04-24 北京飞锐达医疗科技有限公司 Ultrasonic contrast agent with ultra-long duration and preparation method thereof
KR20180133527A (en) 2016-05-04 2018-12-14 랜티우스 메디컬 이메징, 인크. Method and apparatus for producing ultrasound contrast agent
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
CA3032062A1 (en) 2016-08-30 2018-03-08 Bracco Suisse Sa Preparation of size-controlled microparticles
US11147890B2 (en) 2017-02-28 2021-10-19 Children's Medical Center Corporation Stimuli-responsive particles encapsulating a gas and methods of use
CN116650678A (en) 2017-07-07 2023-08-29 德雷克塞尔大学 Voltage activated therapeutic, diagnostic and/or diagnostic constructs
JP2021516684A (en) 2018-03-07 2021-07-08 ブラッコ・スイス・ソシエテ・アノニム Preparation of size-controlled microvesicles

Family Cites Families (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3968203A (en) * 1965-10-01 1976-07-06 Jerome G. Spitzer Aerosol astringent composition
US3615972A (en) * 1967-04-28 1971-10-26 Dow Chemical Co Expansible thermoplastic polymer particles containing volatile fluid foaming agent and method of foaming the same
US3650831A (en) * 1969-03-10 1972-03-21 Armour Dial Inc Method of cleaning surfaces
US3900420A (en) * 1970-05-18 1975-08-19 Felix Sebba Microgas emulsions and method of forming same
US4027007A (en) * 1970-12-09 1977-05-31 Colgate-Palmolive Company Antiperspirants formulated with borax
GB1575343A (en) * 1977-05-10 1980-09-17 Ici Ltd Method for preparing liposome compositions containing biologically active compounds
CH621479A5 (en) 1977-08-05 1981-02-13 Battelle Memorial Institute
CH624011A5 (en) 1977-08-05 1981-07-15 Battelle Memorial Institute
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4256251A (en) * 1978-04-24 1981-03-17 Lawrence M. Smith Surgical staplers and staple
US4192859A (en) * 1978-09-29 1980-03-11 E. R. Squibb & Sons, Inc. Contrast media containing liposomes as carriers
US4276885A (en) 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
US4265251A (en) * 1979-06-28 1981-05-05 Rasor Associates, Inc. Method of determining pressure within liquid containing vessel
US4316391A (en) * 1979-11-13 1982-02-23 Ultra Med, Inc. Flow rate measurement
US4657756A (en) * 1980-11-17 1987-04-14 Schering Aktiengesellschaft Microbubble precursors and apparatus for their production and use
US4681119A (en) * 1980-11-17 1987-07-21 Schering Aktiengesellschaft Method of production and use of microbubble precursors
US4442843A (en) 1980-11-17 1984-04-17 Schering, Ag Microbubble precursors and methods for their production and use
DE3141641A1 (en) 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen ULTRASONIC CONTRAST AGENTS AND THEIR PRODUCTION
US4572203A (en) * 1983-01-27 1986-02-25 Feinstein Steven B Contact agents for ultrasonic imaging
US4718433A (en) * 1983-01-27 1988-01-12 Feinstein Steven B Contrast agents for ultrasonic imaging
US5141738A (en) * 1983-04-15 1992-08-25 Schering Aktiengesellschaft Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use thereof
DE3313946A1 (en) * 1983-04-15 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen MICROPARTICLES AND GAS BUBBLES CONTAINING ULTRASONIC CONTRASTING AGENTS
DE3313947A1 (en) * 1983-04-15 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen MICROPARTICLES AND GAS BUBBLES CONTAINING ULTRASONIC CONTRASTING AGENTS
US4900540A (en) * 1983-06-20 1990-02-13 Trustees Of The University Of Massachusetts Lipisomes containing gas for ultrasound detection
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
DE3324754A1 (en) * 1983-07-06 1985-01-17 Schering AG, 1000 Berlin und 4709 Bergkamen ULTRASONIC CONTRASTING AGENTS AND THEIR PRODUCTION
US5618514A (en) * 1983-12-21 1997-04-08 Nycomed Imaging As Diagnostic and contrast agent
GB8504916D0 (en) 1985-02-26 1985-03-27 Isc Chemicals Ltd Emulsions of perfluorocarbons in aqueous media
DE3529195A1 (en) * 1985-08-14 1987-02-26 Max Planck Gesellschaft CONTRAST AGENTS FOR ULTRASONIC EXAMINATIONS AND METHOD FOR THE PRODUCTION THEREOF
US4684479A (en) * 1985-08-14 1987-08-04 Arrigo Joseph S D Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures
US4927623A (en) * 1986-01-14 1990-05-22 Alliance Pharmaceutical Corp. Dissolution of gas in a fluorocarbon liquid
EP0245019A3 (en) 1986-04-30 1989-05-10 Michael A. Davis Low density contrast medium for diagnosis of pathologic conditions
DE3637926C1 (en) * 1986-11-05 1987-11-26 Schering Ag Ultrasonic manometry in a liquid using microbubbles
FR2608942B1 (en) * 1986-12-31 1991-01-11 Centre Nat Rech Scient PROCESS FOR THE PREPARATION OF COLLOIDAL DISPERSIBLE SYSTEMS OF A SUBSTANCE, IN THE FORM OF NANOCAPSULES
US5283067A (en) * 1987-01-30 1994-02-01 Ciba-Geigy Corporation Parenteral suspensions
US5089181A (en) * 1987-02-24 1992-02-18 Vestar, Inc. Method of dehydrating vesicle preparations for long term storage
CH672733A5 (en) * 1987-05-22 1989-12-29 Bracco Ind Chimica Spa
DE3741201A1 (en) * 1987-12-02 1989-06-15 Schering Ag ULTRASONIC PROCESS AND METHOD FOR IMPLEMENTING IT
IE61591B1 (en) 1987-12-29 1994-11-16 Molecular Biosystems Inc Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production
US4844882A (en) * 1987-12-29 1989-07-04 Molecular Biosystems, Inc. Concentrated stabilized microbubble-type ultrasonic imaging agent
US5425366A (en) * 1988-02-05 1995-06-20 Schering Aktiengesellschaft Ultrasonic contrast agents for color Doppler imaging
WO1989006978A1 (en) 1988-02-05 1989-08-10 Schering Aktiengesellschaft Berlin Und Bergkamen Ultrasonic contrast agents, process for producing them and their use as diagnostic and therapeutic agents
US5171755A (en) 1988-04-29 1992-12-15 Hemagen/Pfc Emulsions of highly fluorinated organic compounds
US5730954A (en) * 1988-08-23 1998-03-24 Schering Aktiengesellschaft Preparation comprising cavitate- or clathrate-forming host/guest complexes as contrast agent
DE3828905A1 (en) * 1988-08-23 1990-03-15 Schering Ag MEDIALLY COMPOSED OF CAVITATE OR CLATHRATE MAKING HOST / GUEST COMPLEX AS A CONTRAST
US4957656A (en) * 1988-09-14 1990-09-18 Molecular Biosystems, Inc. Continuous sonication method for preparing protein encapsulated microbubbles
DE3934656A1 (en) * 1989-10-13 1991-04-18 Schering Ag METHOD FOR PRODUCING AQUEOUS DISPERSIONS
US5149319A (en) * 1990-09-11 1992-09-22 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids
US5228446A (en) * 1989-12-22 1993-07-20 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US5776429A (en) * 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US5088499A (en) * 1989-12-22 1992-02-18 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5585112A (en) * 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5209720A (en) * 1989-12-22 1993-05-11 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes
US5123414A (en) 1989-12-22 1992-06-23 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
DE4004430A1 (en) * 1990-02-09 1991-08-14 Schering Ag CONSTRUCTED POLYALDEHYDE CONSTITUENTS
GB9003821D0 (en) * 1990-02-20 1990-04-18 Danbiosyst Uk Diagnostic aid
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
IN172208B (en) * 1990-04-02 1993-05-01 Sint Sa
US5556610A (en) 1992-01-24 1996-09-17 Bracco Research S.A. Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method
US5137928A (en) * 1990-04-26 1992-08-11 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
US5190982A (en) * 1990-04-26 1993-03-02 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
US5205287A (en) * 1990-04-26 1993-04-27 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
AU636481B2 (en) 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US5215680A (en) 1990-07-10 1993-06-01 Cavitation-Control Technology, Inc. Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles
JP3247374B2 (en) * 1990-10-05 2002-01-15 ブラッコ インターナショナル ベスローテン フェンノートシャップ A method for the production of stable suspensions of hollow gas-encapsulated microspheres suitable for ultrasound ecology
DE4100470A1 (en) * 1991-01-09 1992-07-16 Byk Gulden Lomberg Chem Fab Echo contrast agent
GB9106673D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
GB9106686D0 (en) 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
US5205290A (en) * 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US5874062A (en) * 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
GB9107628D0 (en) * 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
US5147631A (en) * 1991-04-30 1992-09-15 Du Pont Merck Pharmaceutical Company Porous inorganic ultrasound contrast agents
US5364612A (en) * 1991-05-06 1994-11-15 Immunomedics, Inc. Detection of cardiovascular lesions
JP3319754B2 (en) 1991-06-03 2002-09-03 ニユコメド・イメージング・アクシエセルカペト Improvements in or on contrast agents
US5389519A (en) * 1991-08-01 1995-02-14 The Research Foundation Of The State University Of New York Method of screening for infertility
DE4127442C2 (en) * 1991-08-17 1996-08-22 Udo Dr Gros Aqueous dispersion of fluorocarbon-containing phospholipid vesicles and a process for their preparation
HU218018B (en) * 1991-09-17 2000-05-28 Sonus Pharmaceuticals Inc. Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media
US5409688A (en) * 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
MX9205298A (en) * 1991-09-17 1993-05-01 Steven Carl Quay GASEOUS ULTRASOUND CONTRASTING MEDIA AND METHOD FOR SELECTING GASES TO BE USED AS ULTRASOUND CONTRASTING MEDIA
WO1993006869A1 (en) * 1991-10-04 1993-04-15 Mallinckrodt Medical, Inc. Gaseous ultrasound contrast agents
GB9200388D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
IL104084A (en) * 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
BE1006651A3 (en) * 1992-01-24 1994-11-08 Raffinerie Tirlemontoise Sa Sugar pearl, method of making and use in the food industry.
CZ284844B6 (en) 1992-03-06 1999-03-17 Nycomed Imaging A/S Contrasting agent
EP0679066A4 (en) * 1992-11-02 1996-04-03 Univ Drexel Surfactant-stabilized microbubble mixtures, process for preparing and methods of using the same.
WO1994016739A1 (en) * 1993-01-25 1994-08-04 Sonus Pharmaceuticals, Inc. Phase shift colloids as ultrasound contrast agents
US5716597A (en) * 1993-06-04 1998-02-10 Molecular Biosystems, Inc. Emulsions as contrast agents and method of use
BR9406993A (en) * 1993-07-02 1996-09-10 Molecular Biosystems Inc Microspheres of insoluble gases encapsulated with protein and their preparation and use as ultrasonic imaging agents
DK0711179T3 (en) * 1993-07-30 2005-02-14 Imcor Pharmaceutical Co Stabilized ultrasound microbubble compositions
US5562893A (en) * 1994-08-02 1996-10-08 Molecular Biosystems, Inc. Gas-filled microspheres with fluorine-containing shells
US5601085A (en) * 1995-10-02 1997-02-11 Nycomed Imaging As Ultrasound imaging

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9427396B2 (en) 2008-06-27 2016-08-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses

Also Published As

Publication number Publication date
FI953843A (en) 1995-08-14
IS4239A (en) 1995-06-16
US20040197269A1 (en) 2004-10-07
CN1068229C (en) 2001-07-11
ZA949983B (en) 1995-08-22
PL310172A1 (en) 1995-11-27
PT682530E (en) 2003-06-30
AU679295B2 (en) 1997-06-26
US5846518A (en) 1998-12-08
HU9502390D0 (en) 1995-10-30
DE69432295T2 (en) 2003-08-14
EP0682530B1 (en) 2003-03-19
RU2138293C1 (en) 1999-09-27
PL182223B1 (en) 2001-11-30
DK0682530T3 (en) 2003-07-14
NO314019B1 (en) 2003-01-20
FI116365B (en) 2005-11-15
DE69432295D1 (en) 2003-04-24
CZ208995A3 (en) 1996-01-17
JPH10508284A (en) 1998-08-18
HUT73251A (en) 1996-07-29
US6183725B1 (en) 2001-02-06
NO953141D0 (en) 1995-08-10
KR100295173B1 (en) 2001-09-17
IS1739B (en) 1999-12-30
EP0682530A1 (en) 1995-11-22
IL111977A0 (en) 1995-03-15
NO953195D0 (en) 1995-08-14
WO1995016467A1 (en) 1995-06-22
HU225495B1 (en) 2007-01-29
CN1117713A (en) 1996-02-28
IL111977A (en) 2000-06-01
CA2154867C (en) 2007-05-29
ATE234638T1 (en) 2003-04-15
ES2192572T3 (en) 2003-10-16
KR960700757A (en) 1996-02-24
NO953141L (en) 1995-08-10
AU1033095A (en) 1995-07-03
NZ276167A (en) 1996-11-26
FI953843A0 (en) 1995-08-14

Similar Documents

Publication Publication Date Title
CA2154867A1 (en) Gas mixtures useful as ultrasound contrast media
HU9300179D0 (en) Durable water based dispersions or suspensions containing pressure resistant gas-filled microcavities and method for producing them
CA2273140A1 (en) Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media
AU3995997A (en) Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media
AU3431795A (en) Method of making suspensions of air or gas filled microbubbles
WO1999055383A3 (en) Improvements in or relating to diagnostic/therapeutic agents
MY116041A (en) Horizontal carbon dioxide snow horn with adjustment for desired snow
CA2161809A1 (en) Drinking vessel
CA2333354A1 (en) A method and equipment for the production of a gas mixture
RU2002113094A (en) METHOD AND USE OF CALCIUM NITRATE FOR FOAMING SLAGS IN THE PRODUCTION OF STEEL
IT1237347B (en) Foaming flue dust e.g. for use as concrete aggregate
SU1590122A1 (en) Method of producing froth
SU1102802A1 (en) Reagent for preparing aerated drilling mud
JPH07315978A (en) Pressure holding method of gas for air soft gun
RU1789014C (en) Expanding bridging compound
CA2104086A1 (en) Metallothermal Reaction Mixture
DE3662518D1 (en) Process for the systhesis of chloropentafluoroethane from dichlorotetrafluoroethane and fluorohydric acid
Belyaev Effect of Oxygen Content in CO sub 2+ O sub 2 Mixture on Some Characteristics of Welded Metal
MY111060A (en) Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media
JPS6434919A (en) Aerosol preparation for nasal application
UA30673A (en) Foam forming composition for removal of liquid from well bottom zone

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20141201

MKLA Lapsed

Effective date: 20141201