CA2155005A1 - Pharmaceutical Compositions Containing Bactericidal Permeability Increasing Protein and a Surfactant - Google Patents

Pharmaceutical Compositions Containing Bactericidal Permeability Increasing Protein and a Surfactant

Info

Publication number
CA2155005A1
CA2155005A1 CA2155005A CA2155005A CA2155005A1 CA 2155005 A1 CA2155005 A1 CA 2155005A1 CA 2155005 A CA2155005 A CA 2155005A CA 2155005 A CA2155005 A CA 2155005A CA 2155005 A1 CA2155005 A1 CA 2155005A1
Authority
CA
Canada
Prior art keywords
bpi
permeability increasing
pharmaceutical compositions
surfactant
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2155005A
Other languages
French (fr)
Other versions
CA2155005C (en
Inventor
Weldon Courtney Mcgregor
James Stubstad
C. Paul Chang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xoma Corp
Original Assignee
Weldon Courtney Mcgregor
James Stubstad
C. Paul Chang
Xoma Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Weldon Courtney Mcgregor, James Stubstad, C. Paul Chang, Xoma Corporation filed Critical Weldon Courtney Mcgregor
Publication of CA2155005A1 publication Critical patent/CA2155005A1/en
Application granted granted Critical
Publication of CA2155005C publication Critical patent/CA2155005C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1751—Bactericidal/permeability-increasing protein [BPI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Bactericidal/permeability increasing (BPI) polypeptide pharmaceutical compositions having improved stability and resistance to aggregation, particle formation and precipitation comprising the polypeptide pharmaceutical and poloxamer surfactants alone, or in combination with polysorbate suractants. Preferred BPI polypeptides stabilized are bactericidal/permeability increasing (BPI) protein, biologically active fragments of BPI, and biologically active analogs of BPI.
CA002155005A 1993-02-02 1994-02-02 Pharmaceutical compositions containing bactericidal permeability increasing protein and a surfactant Expired - Fee Related CA2155005C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1236093A 1993-02-02 1993-02-02
US08/012,360 1993-02-02

Publications (2)

Publication Number Publication Date
CA2155005A1 true CA2155005A1 (en) 1994-08-18
CA2155005C CA2155005C (en) 1999-04-06

Family

ID=21754603

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002155005A Expired - Fee Related CA2155005C (en) 1993-02-02 1994-02-02 Pharmaceutical compositions containing bactericidal permeability increasing protein and a surfactant

Country Status (13)

Country Link
US (5) US5488034A (en)
EP (1) EP0682524B1 (en)
JP (2) JP3946246B2 (en)
CN (1) CN1163264C (en)
AT (1) ATE206308T1 (en)
AU (1) AU695125B2 (en)
CA (1) CA2155005C (en)
DE (1) DE69428521T2 (en)
DK (1) DK0682524T3 (en)
ES (1) ES2164098T3 (en)
HK (1) HK1014156A1 (en)
PT (1) PT682524E (en)
WO (1) WO1994017819A1 (en)

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US6759203B1 (en) 1993-09-22 2004-07-06 Xoma Corporation Method for quantifying BPI in body fluids
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Also Published As

Publication number Publication date
CA2155005C (en) 1999-04-06
CN1163264C (en) 2004-08-25
US6255284B1 (en) 2001-07-03
WO1994017819A1 (en) 1994-08-18
PT682524E (en) 2002-03-28
EP0682524B1 (en) 2001-10-04
US6066620A (en) 2000-05-23
US5488034A (en) 1996-01-30
ATE206308T1 (en) 2001-10-15
HK1014156A1 (en) 1999-09-24
AU6133094A (en) 1994-08-29
AU695125B2 (en) 1998-08-06
US5955427A (en) 1999-09-21
DK0682524T3 (en) 2002-01-28
US5696090A (en) 1997-12-09
JPH10513433A (en) 1998-12-22
DE69428521D1 (en) 2001-11-08
JP3946246B2 (en) 2007-07-18
JP2005145986A (en) 2005-06-09
DE69428521T2 (en) 2002-05-23
CN1127992A (en) 1996-07-31
ES2164098T3 (en) 2002-02-16
EP0682524A1 (en) 1995-11-22

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