CA2157577A1 - Growth differentiation factor-8 - Google Patents

Growth differentiation factor-8

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Publication number
CA2157577A1
CA2157577A1 CA002157577A CA2157577A CA2157577A1 CA 2157577 A1 CA2157577 A1 CA 2157577A1 CA 002157577 A CA002157577 A CA 002157577A CA 2157577 A CA2157577 A CA 2157577A CA 2157577 A1 CA2157577 A1 CA 2157577A1
Authority
CA
Canada
Prior art keywords
gdf
cell
vector
antibody
polynucleotide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002157577A
Other languages
French (fr)
Other versions
CA2157577C (en
Inventor
Se-Jin Lee
Alexandra C. Mcpherron
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School of Medicine of Johns Hopkins University
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Individual
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Publication of CA2157577A1 publication Critical patent/CA2157577A1/en
Application granted granted Critical
Publication of CA2157577C publication Critical patent/CA2157577C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Growth differentiation factor-8 (GDF-8) is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of using the GDF-8 polypeptide and polynucleotide sequences.

Claims (43)

1. Substantially pure growth differentiation factor-8 (GDF-8) and functional fragments thereof.
2. An isolated polynucleotide sequence encoding the GDF-8 polypeptide of claim 1.
3. The polynucleotide of claim 2, wherein the GDF-8 nucleotide sequence is selected from the group consisting of the nucleic acid sequence of a. FIGURE 5a, wherein T can also be U;
b. FIGURE 5b, wherein T can also be U;
c. nucleic acid sequences complementary to FIGURE 5a;
d. nucleic acid sequences complementary to FIGURE 5b;
e. fragments of a. or c. that are at least 15 bases in length and that will selectively hybridize to genomic DNA which encodes the GDF-8 protein of FIGURE 5a; and f. fragments of b. or d. that are at least 15 bases in length and that will selectively hybridize to genomic DNA which encodes the GDF-8 protein of FIGURE 5b.
4. The polynucleotide sequence of claim 2, wherein the polynucleotide is isolated from a mammalian cell.
5. The polynucleotide of claim 4, wherein the mammalian cell is selected from the group consisting of mouse, rat, and human cell.
6. An expression vector including the polynucleotide of claim 2
7. The vector of claim 6, wherein the vector is a plasmid.
8. The vector of claim 6, wherein the vector is a virus.
9. A host cell stably transformed with the vector of claim 6.
10. The host cell of claim 9, wherein the cell is prokaryotic.
11. The host cell of claim 9, wherein the cell is eukaryotic.
12. Antibodies reactive with the polypeptide of claim 1 or fragments thereof.
13. The antibodies of claim 12, wherein the antibodies are polyclonal.
14. The antibodies of claim 12, wherein the antibodies are monoclonal.
15. A method of detecting a cell proliferative disorder comprising contacting the antibody of claim 12 with a specimen of a subject suspected of having a GDF-8 associated disorder and detecting binding of the antibody.
16. The method of claim 15, wherein the cell is a muscle cell.
17. The method of claim 15, wherein the detecting is in vivo.
18. The method of claim 17, wherein the antibody is detectably labeled.
19. The method of claim 18, wherein the detectable label is selected from the group consisting of a radioisotope, a fluorescent compound, a bioluminescent compound and a chemiluminescent compound.
20. The method of claim 15, wherein the detection is in vitro.
21. The method of claim 20, wherein the antibody is detectably labeled.
22. The method of claim 21, wherein the label is selected from the group consisting of a radioisotope, a fluorescent compound, a bioluminescent compound, a chemoluminescent compound and an enzyme.
23. A method of treating a cell proliferative disorder associated with expression of GDF-8, comprising contacting the cells with a reagent which suppresses the GDF-8 activity.
24. The method of claim 23, wherein the reagent is an anti-GDF-8 antibody.
25. The method of claim 23, wherein the reagent is a GDF-8 antisense sequence.
26. The method of claim 23, wherein the cell is a muscle cell.
27. The method of claim 23, wherein the reagent which suppresses GDF-8 activity is introduced to a cell using a vector.
28. The method of claim 27, wherein the vector is a colloidal dispersion system.
29. The method of claim 28, wherein the colloidal dispersion system is a liposome.
30. The method of claim 29, wherein the liposome is essentially target specific.
31. The method of claim 30, wherein the liposome is anatomically targeted.
32. The method of claim 31, wherein the liposome is mechanistically targeted.
33. The method of claim 32, wherein the mechanistic targeting is passive.
34. The method of claim 32, wherein the mechanistic targeting is active.
35. The method of claim 34, wherein the liposome is actively targeted by coupling with a moiety selected from the group consisting of a sugar, a glycolipid, and a protein.
36. The method of claim 35, wherein the protein moiety is an antibody.
37. The method of claim 36, wherein the vector is a virus.
38. The method of claim 37, wherein the virus is an RNA virus.
39. The method of claim 38, wherein the RNA virus is a retrovirus.
40. The method of claim 39, wherein the retrovirus is essentially target specific.
41. The method of claim 40, wherein a moiety for target specificity is encoded by a polynucleotide inserted into the retroviral genome.
42. The method of claim 40, wherein a moiety for target specificity is selected from the group consisting of a sugar, a glycolipid, and a protein.
43. The method of claim 42, wherein the protein is an antibody.
CA002157577A 1993-03-19 1994-03-18 Growth differentiation factor-8 Expired - Lifetime CA2157577C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3392393A 1993-03-19 1993-03-19
US08/033,923 1993-03-19
PCT/US1994/003019 WO1994021681A1 (en) 1993-03-19 1994-03-18 Growth differentiation factor-8

Publications (2)

Publication Number Publication Date
CA2157577A1 true CA2157577A1 (en) 1994-09-29
CA2157577C CA2157577C (en) 2009-11-17

Family

ID=21873232

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002157577A Expired - Lifetime CA2157577C (en) 1993-03-19 1994-03-18 Growth differentiation factor-8

Country Status (8)

Country Link
US (5) US5827733A (en)
EP (2) EP1333035A3 (en)
JP (4) JPH09507829A (en)
CA (1) CA2157577C (en)
DE (1) DE69432815T2 (en)
DK (1) DK0690873T3 (en)
ES (1) ES2201076T3 (en)
WO (1) WO1994021681A1 (en)

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