CA2157890A1 - Calcium Phosphate Hydroxyapatite Precursor and Methods for Making and Using the Same - Google Patents

Calcium Phosphate Hydroxyapatite Precursor and Methods for Making and Using the Same

Info

Publication number
CA2157890A1
CA2157890A1 CA2157890A CA2157890A CA2157890A1 CA 2157890 A1 CA2157890 A1 CA 2157890A1 CA 2157890 A CA2157890 A CA 2157890A CA 2157890 A CA2157890 A CA 2157890A CA 2157890 A1 CA2157890 A1 CA 2157890A1
Authority
CA
Canada
Prior art keywords
methods
calcium phosphate
making
same
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2157890A
Other languages
French (fr)
Other versions
CA2157890C (en
Inventor
Laurence C. Chow
Shozo Takagi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
American Dental Association Health Foundation
Original Assignee
Laurence C. Chow
Shozo Takagi
American Dental Association Health Foundation
Ada Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laurence C. Chow, Shozo Takagi, American Dental Association Health Foundation, Ada Foundation filed Critical Laurence C. Chow
Publication of CA2157890A1 publication Critical patent/CA2157890A1/en
Application granted granted Critical
Publication of CA2157890C publication Critical patent/CA2157890C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/50—Preparations specially adapted for dental root treatment
    • A61K6/54—Filling; Sealing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/831—Preparations for artificial teeth, for filling teeth or for capping teeth comprising non-metallic elements or compounds thereof, e.g. carbon
    • A61K6/838—Phosphorus compounds, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
    • A61K6/864—Phosphate cements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
    • A61K6/876—Calcium oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite

Abstract

Calcium phosphate composition that are particularly useful and unique as orthopedic and dental cements and remineralizers, as well as methods and kits for their use, and the resulting products are disclosed. The compositions comprise tetracalcium phosphate which has been prepared from a mixture with a calcium to phosphorous ratio of less than 2, or prepared and maintained under substantially anhydrous conditions prior to use or, preferably, both. The novel compositions are converted substantially to hydroxyapatite upon setting, are substantially gradually resorbable and replaced by bone when implanted in contact with living bony tissue, and offer distinct advantages in terms of cement strength, setting time and reliability and other properties.
CA002157890A 1993-03-12 1993-09-15 Calcium phosphate hydroxyapatite precursor and methods for making and using the same Expired - Lifetime CA2157890C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/030,709 US5522893A (en) 1993-03-12 1993-03-12 Calcium phosphate hydroxyapatite precursor and methods for making and using the same
US030,709 1993-03-12

Publications (2)

Publication Number Publication Date
CA2157890A1 true CA2157890A1 (en) 1994-09-15
CA2157890C CA2157890C (en) 1999-02-23

Family

ID=21855603

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002157890A Expired - Lifetime CA2157890C (en) 1993-03-12 1993-09-15 Calcium phosphate hydroxyapatite precursor and methods for making and using the same

Country Status (11)

Country Link
US (5) US5522893A (en)
EP (1) EP0688202B1 (en)
JP (1) JP3017536B2 (en)
KR (1) KR960702294A (en)
AT (1) ATE183382T1 (en)
AU (1) AU684722B2 (en)
BR (1) BR9307825A (en)
CA (1) CA2157890C (en)
DE (1) DE69326082T2 (en)
ES (1) ES2136668T3 (en)
WO (1) WO1994020064A1 (en)

Families Citing this family (173)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9215356D0 (en) * 1992-07-20 1992-09-02 Univ Reading The Bone materials
US5522893A (en) * 1993-03-12 1996-06-04 American Dental Association Health Foundation Calcium phosphate hydroxyapatite precursor and methods for making and using the same
ES2098183B1 (en) * 1994-12-14 1998-02-01 Univ Catalunya Politecnica CEMENTENT PRODUCT OF CALCIUM PHOSPHATE USABLE AS BIOMATERIAL.
CN1038319C (en) * 1994-12-23 1998-05-13 上海华明超细新材料有限公司 Process for preparing high-pure tetracalcium phosphate
US6936277B2 (en) * 1995-01-09 2005-08-30 J. Rettenmaier & Soehne Gmbh & Co. Kg Pharmaceutical excipient having improved compressibility
US6027742A (en) 1995-05-19 2000-02-22 Etex Corporation Bioresorbable ceramic composites
US6287341B1 (en) 1995-05-19 2001-09-11 Etex Corporation Orthopedic and dental ceramic implants
US6132463A (en) * 1995-05-19 2000-10-17 Etex Corporation Cell seeding of ceramic compositions
US6541037B1 (en) 1995-05-19 2003-04-01 Etex Corporation Delivery vehicle
US5676976A (en) * 1995-05-19 1997-10-14 Etex Corporation Synthesis of reactive amorphous calcium phosphates
US6117456A (en) * 1995-05-19 2000-09-12 Etex Corporation Methods and products related to the physical conversion of reactive amorphous calcium phosphate
US7150879B1 (en) 1995-05-19 2006-12-19 Etex Corporation Neutral self-setting calcium phosphate paste
WO1996039202A1 (en) * 1995-06-06 1996-12-12 Osteogenics Inc. Biocompatible hydroxyapatite formulations and uses therefor
US5783217A (en) * 1995-11-07 1998-07-21 Etex Corporation Low temperature calcium phosphate apatite and a method of its manufacture
US6051247A (en) * 1996-05-30 2000-04-18 University Of Florida Research Foundation, Inc. Moldable bioactive compositions
AU4083597A (en) 1996-09-27 1998-04-17 Enamelon, Inc. Improved products and methods for the remineralization and prevention of demineralization of teeth
US6953594B2 (en) 1996-10-10 2005-10-11 Etex Corporation Method of preparing a poorly crystalline calcium phosphate and methods of its use
US8728536B2 (en) * 1996-10-16 2014-05-20 Etex Corporation Chemotherapeutic composition using nanocrystalline calcium phosphate paste
US7517539B1 (en) 1996-10-16 2009-04-14 Etex Corporation Method of preparing a poorly crystalline calcium phosphate and methods of its use
AU734691B2 (en) 1996-10-16 2001-06-21 Life Science Enterprises, Inc. Bioceramic compositions
US6013591A (en) * 1997-01-16 2000-01-11 Massachusetts Institute Of Technology Nanocrystalline apatites and composites, prostheses incorporating them, and method for their production
US5939039A (en) * 1997-01-16 1999-08-17 Orthovita, Inc. Methods for production of calcium phosphate
NL1008582C2 (en) * 1998-01-05 1999-07-06 Vrije Universiteit Bone material.
FR2776282B1 (en) * 1998-03-20 2000-05-19 Toulouse Inst Nat Polytech PROCESS FOR THE PREPARATION OF A HYDROXYAPATITE-BASED BIOMATERIAL, BIOMATERIAL OBTAINED AND SURGICAL OR DENTAL APPLICATION
JP2002519155A (en) * 1998-07-02 2002-07-02 スティヒティング・スケルトル・ティシュー・エンジニアリング・グループ・アムステルダム Bone cement with antimicrobial peptide
US5858333A (en) * 1998-08-07 1999-01-12 Enamelon, Inc. Two-part oral products and methods of using same to remineralize teeth
JP4099271B2 (en) * 1998-09-14 2008-06-11 富士通株式会社 Optical connector
US6383519B1 (en) * 1999-01-26 2002-05-07 Vita Special Purpose Corporation Inorganic shaped bodies and methods for their production and use
WO2000059460A1 (en) * 1999-04-07 2000-10-12 W.R. Grace & Co.-Conn. Additives for desensitizing and remineralizing dentifrice compositions
AU6080500A (en) 1999-07-08 2001-01-30 Cap Biotechnology, Inc. Calcium-containing structures and methods of making and using the same
US6840995B2 (en) * 1999-07-14 2005-01-11 Calcitec, Inc. Process for producing fast-setting, bioresorbable calcium phosphate cements
US6379453B1 (en) * 1999-07-14 2002-04-30 Jiin-Huey Chern Process for producing fast-setting, bioresorbable calcium phosphate cements
US6960249B2 (en) * 1999-07-14 2005-11-01 Calcitec, Inc. Tetracalcium phosphate (TTCP) having calcium phosphate whisker on surface
US7270705B2 (en) * 1999-07-14 2007-09-18 Jiin-Huey Chern Lin Method of increasing working time of tetracalcium phosphate cement paste
US7094282B2 (en) * 2000-07-13 2006-08-22 Calcitec, Inc. Calcium phosphate cement, use and preparation thereof
US7169373B2 (en) * 1999-07-14 2007-01-30 Calcitec, Inc. Tetracalcium phosphate (TTCP) having calcium phosphate whisker on surface and process for preparing the same
US6458162B1 (en) * 1999-08-13 2002-10-01 Vita Special Purpose Corporation Composite shaped bodies and methods for their production and use
WO2001012129A1 (en) * 1999-08-13 2001-02-22 Jeneric/Pentron Incorporated Dental compositions comprising degradable polymers
FR2805748B1 (en) * 2000-03-01 2002-09-13 Ceravic PROCESS FOR THE PREPARATION OF AN INJECTABLE PHOSPHOCALCIC PASTE MATERIAL FOR FORMING AN APATITIC BIOMATERIAL AND SURGICAL OR DENTAL APPLICATION
US7820191B2 (en) 2000-04-28 2010-10-26 Skeletal Kinetics, Llc Calcium phosphate cements prepared from silicate solutions
US6375935B1 (en) 2000-04-28 2002-04-23 Brent R. Constantz Calcium phosphate cements prepared from silicate solutions
DE10032220A1 (en) * 2000-07-03 2002-01-24 Sanatis Gmbh Magnesium ammonium phosphate cements, their manufacture and use
US7204876B2 (en) * 2000-07-13 2007-04-17 Calcitec, Inc. Calcium phosphate cements made from (TTCP) with surface whiskers and process for preparing same
US7156915B2 (en) * 2000-07-13 2007-01-02 Calcitec, Inc. Tetracalcium phosphate (TTCP) with surface whiskers and method of making same
US6787584B2 (en) * 2000-08-11 2004-09-07 Pentron Corporation Dental/medical compositions comprising degradable polymers and methods of manufacture thereof
US6551273B1 (en) 2000-08-23 2003-04-22 Scimed Life Systems, Inc. Catheter having a shaft keeper
US6808561B2 (en) * 2000-10-16 2004-10-26 University Of South Carolina Biocompatible cement containing reactive calcium phosphate nanoparticles and methods for making and using such cement
US7052517B2 (en) * 2000-10-24 2006-05-30 Vita Special Purpose Corporation Delivery device for biological composites and method of preparation thereof
US6736799B1 (en) 2000-10-24 2004-05-18 Vita Licensing, Inc. Delivery device for biological composites and method of preparation thereof
AU2007221771B2 (en) * 2000-11-16 2010-04-01 Biotomo Pty Ltd Processes for treating coral and coating an object
US20020114795A1 (en) 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
US6793725B2 (en) * 2001-01-24 2004-09-21 Ada Foundation Premixed calcium phosphate cement pastes
US7709029B2 (en) * 2001-01-24 2010-05-04 Ada Foundation Calcium-containing restoration materials
US7294187B2 (en) * 2001-01-24 2007-11-13 Ada Foundation Rapid-hardening calcium phosphate cement compositions
EP1386894A4 (en) * 2001-03-28 2006-11-29 Pentax Corp Kneaded product containing calcium phosphate cement and method for preparation thereof
WO2002083194A1 (en) 2001-04-12 2002-10-24 Therics, Inc. Method and apparatus for engineered regenerative biostructures
US20030055512A1 (en) * 2001-05-21 2003-03-20 Genin Francois Y. Calcium based neutral and bioresorbable bone graft
US8740987B2 (en) * 2001-06-04 2014-06-03 Warsaw Orthopedic, Inc. Tissue-derived mesh for orthopedic regeneration
US6616742B2 (en) 2001-08-30 2003-09-09 Cana Lab Corporation Process for preparing a paste from calcium phosphate cement
EP1443981B1 (en) * 2001-11-14 2015-05-20 Ecole Polytechnique Fédérale de Lausanne (EPFL) Pasty multiple constituent compositions for injectable calcium phosphate cements
US6878168B2 (en) 2002-01-03 2005-04-12 Edwards Lifesciences Corporation Treatment of bioprosthetic tissues to mitigate post implantation calcification
US6955716B2 (en) 2002-03-01 2005-10-18 American Dental Association Foundation Self-hardening calcium phosphate materials with high resistance to fracture, controlled strength histories and tailored macropore formation rates
US20040137032A1 (en) * 2002-03-15 2004-07-15 Wang Francis W. Combinations of calcium phosphates, bone growth factors, and pore-forming additives as osteoconductive and osteoinductive composite bone grafts
EP1364661A1 (en) * 2002-05-15 2003-11-26 Central Medical Technologies Inc. Calcium sulfate composition with controlled working time for bone treatment
US20030216777A1 (en) * 2002-05-16 2003-11-20 Yin-Chun Tien Method of enhancing healing of interfacial gap between bone and tendon or ligament
US7273523B2 (en) 2002-06-07 2007-09-25 Kyphon Inc. Strontium-apatite-cement-preparations, cements formed therefrom, and uses thereof
SG145565A1 (en) * 2002-08-12 2008-09-29 Osteotech Inc Synthesis of a bone-polymer composite material
US20050251267A1 (en) * 2004-05-04 2005-11-10 John Winterbottom Cell permeable structural implant
US20040141903A1 (en) * 2003-01-17 2004-07-22 Howmedica Osteonics Corp. Calcium phosphate cement precursors
JP2006516467A (en) * 2003-02-04 2006-07-06 オステオテック，インコーポレイテッド Polyurethane for bone implants
US7985414B2 (en) * 2003-02-04 2011-07-26 Warsaw Orthopedic, Inc. Polyurethanes for osteoimplants
CA2521623C (en) * 2003-04-11 2015-03-17 Etex Corporation Osteoinductive bone material
US20040250730A1 (en) * 2003-06-12 2004-12-16 David Delaney Calcium phosphate cements prepared from silicate-phosphate solutions
US20040250729A1 (en) * 2003-06-16 2004-12-16 Jang Bor Z. Fast-setting carbonated hydroxyapatite compositions and uses
US20040254668A1 (en) * 2003-06-16 2004-12-16 Jang Bor Z. Macro-porous hydroxyapatite scaffold compositions and freeform fabrication method thereof
US7619016B2 (en) * 2003-07-02 2009-11-17 Ada Foundation Remineralizing dental cements
US7306786B2 (en) 2003-07-28 2007-12-11 Skeletal Kinetics, Llc Calcium phosphate cements comprising a water-soluble contrast agent
US7118705B2 (en) * 2003-08-05 2006-10-10 Calcitec, Inc. Method for making a molded calcium phosphate article
US7163651B2 (en) * 2004-02-19 2007-01-16 Calcitec, Inc. Method for making a porous calcium phosphate article
US6994726B2 (en) 2004-05-25 2006-02-07 Calcitec, Inc. Dual function prosthetic bone implant and method for preparing the same
US7261718B2 (en) 2003-09-11 2007-08-28 Skeletal Kinetics Llc Use of vibration with polymeric bone cements
US7261717B2 (en) * 2003-09-11 2007-08-28 Skeletal Kinetics Llc Methods and devices for delivering orthopedic cements to a target bone site
CA2545185A1 (en) * 2003-11-07 2005-05-26 Calcitec, Inc. Spinal fusion procedure using an injectable bone substitute
US7252833B2 (en) * 2003-11-18 2007-08-07 Skeletal Kinetics, Llc Calcium phosphate cements comprising an osteoclastogenic agent
US8012210B2 (en) 2004-01-16 2011-09-06 Warsaw Orthopedic, Inc. Implant frames for use with settable materials and related methods of use
JP2007519492A (en) * 2004-01-30 2007-07-19 オステオテック，インコーポレイテッド Stacked implant for spinal fusion
US7189263B2 (en) * 2004-02-03 2007-03-13 Vita Special Purpose Corporation Biocompatible bone graft material
US8118812B2 (en) 2004-03-09 2012-02-21 Skeletal Kinetics, Llc Use of vibration in composite fixation
US9707024B2 (en) 2004-03-09 2017-07-18 Skeletal Kinetics, Llc Use of vibration in composite fixation
EP1742648A4 (en) * 2004-04-15 2009-03-04 Etex Corp Delayed-setting calcium phosphate pastes
MXPA06012420A (en) 2004-04-27 2007-03-28 Kyphon Inc Bone substitute compositions and method of use.
DE102004025030A1 (en) * 2004-05-18 2005-12-15 S&C Polymer Silicon- und Composite-Spezialitäten GmbH Nano-apatite fillers containing curable restorative materials
US7252841B2 (en) * 2004-05-20 2007-08-07 Skeletal Kinetics, Llc Rapid setting calcium phosphate cements
US20050257714A1 (en) * 2004-05-20 2005-11-24 Constantz Brent R Orthopedic cements comprising a barium apatite contrast agent
EP1604693A1 (en) * 2004-06-09 2005-12-14 Scil Technology GmbH In situ forming scaffold, its manufacturing and use
US9220595B2 (en) 2004-06-23 2015-12-29 Orthovita, Inc. Shapeable bone graft substitute and instruments for delivery thereof
US7175858B2 (en) 2004-07-26 2007-02-13 Skeletal Kinetics Llc Calcium phosphate cements and methods for using the same
KR100898218B1 (en) * 2004-09-14 2009-05-18 재팬 사이언스 앤드 테크놀로지 에이젼시 Ceramic Particle Group and Method for Production Thereof and Use Thereof
US20060115437A1 (en) * 2004-11-26 2006-06-01 Robert Hayman Dental whitening compositions
US20080050408A1 (en) * 2004-11-26 2008-02-28 Discus Dental, Llc Dental Whitening Compositions
US7312989B2 (en) * 2004-12-06 2007-12-25 Chenbro Micom Co., Ltd. Cooler
US7713542B2 (en) 2005-01-14 2010-05-11 Ada Foundation Three dimensional cell protector/pore architecture formation for bone and tissue constructs
US8480629B2 (en) 2005-01-28 2013-07-09 Boston Scientific Scimed, Inc. Universal utility board for use with medical devices and methods of use
US20060173477A1 (en) * 2005-02-03 2006-08-03 Lin Jiin-Huey C Dual function prosthetic bone implant and method for preparing the same
US20060198863A1 (en) * 2005-03-03 2006-09-07 Musculoskeletal Transplant Foundation Ceramic composition for filling bone defects
US7416602B2 (en) * 2005-04-08 2008-08-26 Howmedica Leibinger, Inc. Calcium phosphate cement
US7459018B2 (en) * 2005-04-08 2008-12-02 Howmedica Leibinger Inc. Injectable calcium phosphate cement
US9060820B2 (en) 2005-05-18 2015-06-23 Sonoma Orthopedic Products, Inc. Segmented intramedullary fracture fixation devices and methods
US8961516B2 (en) 2005-05-18 2015-02-24 Sonoma Orthopedic Products, Inc. Straight intramedullary fracture fixation devices and methods
US8287541B2 (en) 2005-05-18 2012-10-16 Sonoma Orthopedic Products, Inc. Fracture fixation device, tools and methods
US7909825B2 (en) 2006-11-22 2011-03-22 Sonoma Orthepedic Products, Inc. Fracture fixation device, tools and methods
AU2006247498A1 (en) 2005-05-18 2006-11-23 Sonoma Orthopedic Products, Inc. Minimally invasive actuable bone fixation devices, systems and methods of use
US20060270752A1 (en) * 2005-05-26 2006-11-30 Ada Foundation Dental releasing materials
US20070123604A1 (en) * 2005-05-26 2007-05-31 Ada Foundation Dental releasing materials
US7651701B2 (en) * 2005-08-29 2010-01-26 Sanatis Gmbh Bone cement composition and method of making the same
US9259439B2 (en) * 2005-10-21 2016-02-16 Ada Foundation Dual-phase cement precursor systems for bone repair
AU2006304803A1 (en) * 2005-10-21 2007-04-26 Ada Foundation Dental and endodontic filling materials and methods
US9101436B2 (en) * 2005-10-21 2015-08-11 Ada Foundation Dental and endodontic filling materials and methods
ES2726355T3 (en) * 2005-11-14 2019-10-03 Biomet 3I Llc Deposition of discrete nanoparticles on an implant surface
US8147860B2 (en) 2005-12-06 2012-04-03 Etex Corporation Porous calcium phosphate bone material
US8287914B2 (en) * 2006-01-12 2012-10-16 Rutgers, The State University Of New Jersey Biomimetic hydroxyapatite synthesis
US8906151B2 (en) 2006-01-16 2014-12-09 Kuraray Noritake Dental Inc. Calcium phosphate composition and process for producing the same
CA2637606C (en) 2006-01-19 2013-03-19 Osteotech, Inc. Porous osteoimplant
EP1976460A4 (en) 2006-01-19 2012-06-20 Warsaw Orthopedic Inc Injectable and moldable bone substitute materials
US8518383B2 (en) * 2006-02-03 2013-08-27 Wm. Wrigley Jr. Company Oral care products comprising buffer systems for improved mineralization/remineralization benefits
US7754005B2 (en) * 2006-05-02 2010-07-13 Kyphon Sarl Bone cement compositions comprising an indicator agent and related methods thereof
US7507286B2 (en) * 2006-06-08 2009-03-24 Sanatis Gmbh Self-foaming cement for void filling and/or delivery systems
EP2040765A2 (en) 2006-06-29 2009-04-01 Orthovita, INC. Bioactive bone graft substitute
WO2008039382A2 (en) * 2006-09-21 2008-04-03 Kyphon Sarl Diammonium phosphate and other ammonium salts and their use in preventing clotting
ES2729425T3 (en) 2006-10-24 2019-11-04 Biomet 3I Llc Deposition of discrete nanoparticles on a nanostructured surface of an implant
WO2008073190A2 (en) * 2006-11-03 2008-06-19 Kyphon Sarl Materials and methods and systems for delivering localized medical treatments
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
US8288344B2 (en) * 2007-03-15 2012-10-16 Musculoskeletal Transplant Foundation Ceramic composition for filling bone defects
US20100055018A1 (en) * 2007-04-13 2010-03-04 Dr. H.C. Robert Mathys Stiftung Method for producing pyrogene-free calcium phosphate
US20090036564A1 (en) * 2007-08-03 2009-02-05 Feng-Huei Lin Bio-Degenerable Bone Cement and Manufacturing Method thereof
US8357387B2 (en) * 2007-12-21 2013-01-22 Edwards Lifesciences Corporation Capping bioprosthetic tissue to reduce calcification
WO2009097218A1 (en) * 2008-01-28 2009-08-06 Biomet 3I, Llc Implant surface with increased hydrophilicity
US20090198345A1 (en) * 2008-02-04 2009-08-06 Chung Shan Medical University Calcium silicate-based composite cement and manufacturing method thereof
US20100082072A1 (en) * 2008-03-28 2010-04-01 Sybert Daryl R Bone anchors for orthopedic applications
US7968616B2 (en) * 2008-04-22 2011-06-28 Kyphon Sarl Bone cement composition and method
GB0813659D0 (en) 2008-07-25 2008-09-03 Smith & Nephew Fracture putty
EP2341857A2 (en) 2008-09-26 2011-07-13 Sonoma Orthopedic Products, Inc. Bone fixation device, tools and methods
AU2009317974A1 (en) * 2008-10-30 2010-05-27 Vanderbilt University Bone/polyurethane composites and methods thereof
WO2012134540A2 (en) 2010-10-22 2012-10-04 Vanderbilt University Injectable synthetic pur composite
EP2365994B1 (en) 2008-11-12 2017-01-04 Howmedica Osteonics Corp. Tetra calcium phosphate based organophosphorus compositions and methods
JP5501346B2 (en) * 2009-03-30 2014-05-21 クラレノリタケデンタル株式会社 Method for producing tooth mineralizer
US20120027829A1 (en) 2009-03-30 2012-02-02 Kuraray Medical Inc. Dentin mineralizing agent and method for production thereof
WO2010124110A1 (en) * 2009-04-22 2010-10-28 American Dental Association Foundation Dual-phase calcium phosphate cement composition
US8741268B2 (en) * 2009-09-10 2014-06-03 Preventive Technologies, Inc. Dental prophylactic paste
US8142194B2 (en) * 2009-11-16 2012-03-27 Innovative Health Technologies, Llc Implants and methods for performing gums and bone augmentation and preservation
EP2512537B1 (en) * 2009-12-18 2015-08-26 Howmedica Osteonics Corp. Dual paste direct injectable bone cement precursor systems and methods of making same
US20110151027A1 (en) * 2009-12-21 2011-06-23 Theodore D Clineff Strontium-doped calcium phosphate bone graft materials
US9186433B2 (en) 2010-02-22 2015-11-17 National University Corporation Okayama University Kit for adhering biological hard tissues
US8641418B2 (en) 2010-03-29 2014-02-04 Biomet 3I, Llc Titanium nano-scale etching on an implant surface
CA2798710C (en) 2010-05-11 2019-08-27 Venkat R. Garigapati Organophosphorous, multivalent metal compounds, & polymer adhesive interpenetrating network compositions & methods
GB201016970D0 (en) * 2010-10-08 2010-11-24 Univ Leeds Composition
ES2714701T3 (en) 2010-11-10 2019-05-29 Stryker European Holdings I Llc Process for the preparation of a polymeric bone foam
CA2817584C (en) 2010-11-15 2018-01-02 Zimmer Orthobiologics, Inc. Bone void fillers
US8551525B2 (en) 2010-12-23 2013-10-08 Biostructures, Llc Bone graft materials and methods
US9050163B2 (en) 2011-03-21 2015-06-09 Endo Pharmaceuticals Inc. Urethral anastomosis device and method
WO2012158527A2 (en) 2011-05-13 2012-11-22 Howmedica Osteonics Organophosphorous & multivalent metal compound compositions & methods
EP2828100B1 (en) 2012-03-20 2018-05-16 Biomet 3i, LLC Surface treatment for an implant surface
EP2897532A1 (en) 2012-09-18 2015-07-29 Endo Pharmaceuticals Inc. Urethral anastomosis device
EP2967556A1 (en) 2013-03-14 2016-01-20 Endo Pharmaceuticals Inc. Urethral anastomosis device
US9168114B2 (en) 2013-10-17 2015-10-27 B & D Dental Corp. Method of making a dental prosthesis
US9770278B2 (en) 2014-01-17 2017-09-26 Arthrex, Inc. Dual tip guide wire
GB201417020D0 (en) * 2014-09-26 2014-11-12 Univ Leeds And Univ St Andrews The Formulation
US9814499B2 (en) 2014-09-30 2017-11-14 Arthrex, Inc. Intramedullary fracture fixation devices and methods
US10219986B2 (en) 2015-03-04 2019-03-05 Modern Ideas LLC Stabilized calcium phosphate and methods of forming same
US9956314B2 (en) 2016-01-26 2018-05-01 Modern Ideas LLC Adhesive for use with bone and bone-like structures
WO2018104446A2 (en) * 2016-12-07 2018-06-14 Solvay Sa MULTI-POLLUTANT GAS PURIFICATION PROCESS WITH ALKALI SORBENT AND DeNOx SUPPORTED CATALYST COMPRISING Ca-DEFICIENT HYDROXYAPATITE
US11752072B2 (en) 2019-03-11 2023-09-12 University Of Utah Research Foundation Quick set cements for dental pulp capping and related methods of use
CA3168623A1 (en) 2020-01-29 2021-08-05 TEIXEIRA, Marcelo Rodrigues Oral composition with synergistic association of organic and inorganic components for complete maintenance of oral health, method for obtaining same and uses

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2008010C3 (en) * 1970-02-20 1980-07-10 Schneider Gmbh & Co, 5020 Frechen Process for the manufacture of dental implants
US3679360A (en) * 1970-06-26 1972-07-25 Nasa Process for the preparation of brushite crystals
US3787900A (en) * 1971-06-09 1974-01-29 Univ Iowa State Res Found Artificial bone or tooth prosthesis material
US3929971A (en) * 1973-03-30 1975-12-30 Research Corp Porous biomaterials and method of making same
US3913229A (en) * 1974-02-25 1975-10-21 Miter Inc Dental treatments
US4097935A (en) * 1976-07-21 1978-07-04 Sterling Drug Inc. Hydroxylapatite ceramic
DE2928007A1 (en) * 1979-07-11 1981-01-15 Riess Guido Dr BONE IMPLANT BODY FOR PROSTHESES AND BONE CONNECTORS AND METHOD FOR THE PRODUCTION THEREOF
JPS5654841A (en) * 1979-10-08 1981-05-15 Mitsubishi Mining & Cement Co Bone broken portion and filler for void portion and method of treating bone of animal using said filler
JPS5858041A (en) * 1981-10-05 1983-04-06 三菱鉱業セメント株式会社 Bone defficient part and void part filling material
USRE33221E (en) * 1982-04-29 1990-05-22 American Dental Association Health Foundation Dental restorative cement pastes
USRE33161E (en) * 1982-04-29 1990-02-06 American Dental Association Health Foundation Combinations of sparingly soluble calcium phosphates in slurries and pastes as mineralizers and cements
US4612053A (en) * 1983-10-06 1986-09-16 American Dental Association Health Foundation Combinations of sparingly soluble calcium phosphates in slurries and pastes as mineralizers and cements
JPH0822731B2 (en) * 1986-05-21 1996-03-06 昭和電工株式会社 Dental material Ca -4 below P-2 below O-9 below Powder manufacturing method
JP2543685B2 (en) * 1986-10-31 1996-10-16 旭光学工業株式会社 Method for producing calcium phosphate
JP2501213B2 (en) 1987-07-27 1996-05-29 住友大阪セメント株式会社 Bone glue
US5129905A (en) * 1988-04-20 1992-07-14 Norian Corporation Methods for in situ prepared calcium phosphate minerals
US4880610A (en) * 1988-04-20 1989-11-14 Norian Corporation In situ calcium phosphate minerals--method and composition
US5047031A (en) * 1988-04-20 1991-09-10 Norian Corporation In situ calcium phosphate minerals method
US5053212A (en) * 1988-04-20 1991-10-01 Norian Corporation Intimate mixture of calcium and phosphate sources as precursor to hydroxyapatite
JPH0643263B2 (en) 1988-05-31 1994-06-08 徳山曹達株式会社 Curable composition
JPH0773602B2 (en) * 1988-07-23 1995-08-09 新田ゼラチン株式会社 Medical and dental curable materials
US5034059A (en) * 1989-02-17 1991-07-23 Norian Corporation Composition comprising octacalcium phosphate crystals and polypeptide
JPH0645487B2 (en) * 1989-05-19 1994-06-15 徳山曹達株式会社 Curing material
US5037639A (en) * 1989-05-24 1991-08-06 American Dental Association Health Foundation Methods and compositions for mineralizing calcified tissues
JP2584877B2 (en) 1989-12-08 1997-02-26 共立窯業原料株式会社 Method for producing tetracalcium phosphate
JP2535424B2 (en) * 1989-12-22 1996-09-18 共立窯業原料株式会社 Method for producing tetracalcium phosphate
JPH0780683B2 (en) 1990-06-27 1995-08-30 大阪セメント株式会社 Tetracalcium phosphate and tetracalcium phosphate cured product
DE4124898A1 (en) * 1990-07-27 1992-01-30 Osaka Cement APETITE-CONTAINED TETRACALCIUM PHOSPHATE PARTICLES
US5037634A (en) * 1990-08-16 1991-08-06 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Oral compositions containing stabilized copper
EP0520690B1 (en) * 1991-06-26 1995-11-02 Nitta Gelatin Inc. Calcium phosphate type hardening material for repairing living hard tissue
CA2070047A1 (en) * 1991-06-28 1992-12-29 Richard J. Sadey Metal foil with improved peel strength and method for making said foil
US5522893A (en) * 1993-03-12 1996-06-04 American Dental Association Health Foundation Calcium phosphate hydroxyapatite precursor and methods for making and using the same
JP3183605B2 (en) 1994-06-09 2001-07-09 日本電信電話株式会社 WDM optical soliton transmission system

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US6325992B1 (en) 2001-12-04
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JP3017536B2 (en) 2000-03-13
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