CA2158640A1 - Quantitative and qualitative in vivo tissue examination using time resolved spectroscopy - Google Patents

Quantitative and qualitative in vivo tissue examination using time resolved spectroscopy

Info

Publication number
CA2158640A1
CA2158640A1 CA002158640A CA2158640A CA2158640A1 CA 2158640 A1 CA2158640 A1 CA 2158640A1 CA 002158640 A CA002158640 A CA 002158640A CA 2158640 A CA2158640 A CA 2158640A CA 2158640 A1 CA2158640 A1 CA 2158640A1
Authority
CA
Canada
Prior art keywords
integrator
photons
tissue
qualitative
quantitative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002158640A
Other languages
French (fr)
Other versions
CA2158640C (en
Inventor
Britton Chance
Kenneth J. Kaufmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Non Invasive Technology Inc
Original Assignee
Britton Chance
Kenneth J. Kaufmann
Nim Incorporated
Photonics Research Corporation
Ip Company
Non-Invasive Technology, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Britton Chance, Kenneth J. Kaufmann, Nim Incorporated, Photonics Research Corporation, Ip Company, Non-Invasive Technology, Inc. filed Critical Britton Chance
Publication of CA2158640A1 publication Critical patent/CA2158640A1/en
Application granted granted Critical
Publication of CA2158640C publication Critical patent/CA2158640C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14553—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted for cerebral tissue

Abstract

A system for examination of biological tissue of a subject (10) includes a light source (14), (16), a light detector (22), a gated integrator (26), (28), and an integrator timing control (19) adapted to integrate detected photons over at least two selected time intervals.
The light source (14), (16) is adapted to introduce into the tissue, at an input port, pulses of electromagnetic radiation of a selected wavelength in the visible or infrared range. The detector (22) detects photons of modified pulses that have migrated in the tissue from the input port. The integrator (26), (28) registers all photons detected over preselected time intervals of the arrival time of the modified pulses.
A processor (30) adapted to receive data from the integrator (26), (28) determines a physiological property of the examined tissue based on the number of photons integrated over each time interval.
CA002158640A 1993-03-30 1994-03-30 Quantitative and qualitative in vivo tissue examination using time resolved spectroscopy Expired - Lifetime CA2158640C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/040,168 US5386827A (en) 1993-03-30 1993-03-30 Quantitative and qualitative in vivo tissue examination using time resolved spectroscopy
US08/040,168 1993-03-30
PCT/US1994/003518 WO1994022361A1 (en) 1993-03-30 1994-03-30 Quantitative and qualitative in vivo tissue examination using time resolved spectroscopy

Publications (2)

Publication Number Publication Date
CA2158640A1 true CA2158640A1 (en) 1994-10-13
CA2158640C CA2158640C (en) 2005-06-07

Family

ID=21909498

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002158640A Expired - Lifetime CA2158640C (en) 1993-03-30 1994-03-30 Quantitative and qualitative in vivo tissue examination using time resolved spectroscopy

Country Status (8)

Country Link
US (1) US5386827A (en)
EP (1) EP0691820B1 (en)
JP (2) JP3613732B2 (en)
CN (1) CN1039190C (en)
CA (1) CA2158640C (en)
DE (1) DE69432218T2 (en)
HK (1) HK1014642A1 (en)
WO (1) WO1994022361A1 (en)

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Also Published As

Publication number Publication date
DE69432218T2 (en) 2004-02-19
WO1994022361A1 (en) 1994-10-13
CA2158640C (en) 2005-06-07
US5386827A (en) 1995-02-07
CN1039190C (en) 1998-07-22
CN1120307A (en) 1996-04-10
EP0691820B1 (en) 2003-03-05
EP0691820A4 (en) 1998-07-15
JP3665061B2 (en) 2005-06-29
EP0691820A1 (en) 1996-01-17
JP2004195247A (en) 2004-07-15
JP3613732B2 (en) 2005-01-26
DE69432218D1 (en) 2003-04-10
JPH08508429A (en) 1996-09-10
HK1014642A1 (en) 1999-09-30

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