CA2164344A1 - Tablet coating based on a melt-spun mixture of a saccharide and a polymer - Google Patents

Tablet coating based on a melt-spun mixture of a saccharide and a polymer

Info

Publication number
CA2164344A1
CA2164344A1 CA002164344A CA2164344A CA2164344A1 CA 2164344 A1 CA2164344 A1 CA 2164344A1 CA 002164344 A CA002164344 A CA 002164344A CA 2164344 A CA2164344 A CA 2164344A CA 2164344 A1 CA2164344 A1 CA 2164344A1
Authority
CA
Canada
Prior art keywords
particulates
melt
polymer
saccharide
coating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002164344A
Other languages
French (fr)
Other versions
CA2164344C (en
Inventor
Stanley Lech
John Denick Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Stanley Lech
John Denick Jr.
Warner-Lambert Company
Warner-Lambert Company Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stanley Lech, John Denick Jr., Warner-Lambert Company, Warner-Lambert Company Llc filed Critical Stanley Lech
Publication of CA2164344A1 publication Critical patent/CA2164344A1/en
Application granted granted Critical
Publication of CA2164344C publication Critical patent/CA2164344C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893—Tablet coating processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

A method for coating pharmaceutical tablets is disclosed in which polymeric coating ingredients an combined with saccharides in a melt spinning operation to form composite particulates. The particulates are then dispersed in water to form an aqueous polymer coating solution, followed by application to pharmaceutical tablets by such methods as spray coating. The particulates dissolve extremely rapidly in water to form a dispersion of the polymer coating ingredients. Such rapid dissolution allows for increased processing rates and avoids disadvantages of the prior art such as the requirement of high shear rate mixing for long times.
CA002164344A 1993-08-30 1994-05-11 Tablet coating based on a melt-spun mixture of a saccharide and a polymer Expired - Fee Related CA2164344C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11347693A 1993-08-30 1993-08-30
US113,476 1993-08-30
PCT/US1994/005228 WO1995006462A1 (en) 1993-08-30 1994-05-11 Tablet coating based on a melt-spun mixture of a saccharide and apolymer

Publications (2)

Publication Number Publication Date
CA2164344A1 true CA2164344A1 (en) 1995-03-09
CA2164344C CA2164344C (en) 2004-06-29

Family

ID=22349668

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002164344A Expired - Fee Related CA2164344C (en) 1993-08-30 1994-05-11 Tablet coating based on a melt-spun mixture of a saccharide and a polymer

Country Status (6)

Country Link
US (2) US5641536A (en)
EP (1) EP0716597A1 (en)
JP (1) JPH09501947A (en)
AU (1) AU680019B2 (en)
CA (1) CA2164344C (en)
WO (1) WO1995006462A1 (en)

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US6417227B1 (en) 1999-04-28 2002-07-09 Cg And Associates Methods of delivery of cetyl myristoleate
JP4044709B2 (en) * 1999-11-19 2008-02-06 信越化学工業株式会社 Water-based film coating agent and oral solid preparation
DE10033023A1 (en) * 2000-07-07 2002-01-31 Biogrund Gmbh Film coating composition based on cellulose derivatives and sugar alcohols
US7867516B2 (en) * 2001-01-29 2011-01-11 Shionogi & Co., Ltd. Medicinal preparation containing 5-methyl-1-phenyl-2-(1h)-pyridone as active ingredient
AU4061702A (en) * 2001-05-15 2003-04-03 Mcneil-Ppc, Inc. Dip coating compositions containing starch or dextrin
US20030070584A1 (en) * 2001-05-15 2003-04-17 Cynthia Gulian Dip coating compositions containing cellulose ethers
US6620426B2 (en) * 2001-06-05 2003-09-16 Isp Investments Inc. Tablet coating composition
CN1283232C (en) * 2001-09-04 2006-11-08 陶氏环球技术公司 Process for coating solid particles
US8309118B2 (en) * 2001-09-28 2012-11-13 Mcneil-Ppc, Inc. Film forming compositions containing sucralose
MXPA04002979A (en) * 2001-09-28 2005-06-20 Johnson & Johnson Modified release dosage forms.
US8603514B2 (en) 2002-04-11 2013-12-10 Monosol Rx, Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US20070281003A1 (en) 2001-10-12 2007-12-06 Fuisz Richard C Polymer-Based Films and Drug Delivery Systems Made Therefrom
US11207805B2 (en) 2001-10-12 2021-12-28 Aquestive Therapeutics, Inc. Process for manufacturing a resulting pharmaceutical film
US10285910B2 (en) 2001-10-12 2019-05-14 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions
US20110033542A1 (en) 2009-08-07 2011-02-10 Monosol Rx, Llc Sublingual and buccal film compositions
US7357891B2 (en) 2001-10-12 2008-04-15 Monosol Rx, Llc Process for making an ingestible film
US8765167B2 (en) 2001-10-12 2014-07-01 Monosol Rx, Llc Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US8900498B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for manufacturing a resulting multi-layer pharmaceutical film
US20190328679A1 (en) 2001-10-12 2019-10-31 Aquestive Therapeutics, Inc. Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US8900497B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for making a film having a substantially uniform distribution of components
NZ534513A (en) * 2002-02-26 2007-04-27 Astrazeneca Ab Pharmaceutical formulation of iressa comprising a water-soluble cellulose derivative
US7429619B2 (en) * 2002-08-02 2008-09-30 Mcneil Consumer Healthcare Polyacrylic film forming compositions
US20060051420A1 (en) * 2002-11-20 2006-03-09 Pieter De Haan Pharmaceutical tablets containing tibolone and a coating
GB0317663D0 (en) * 2003-07-29 2003-09-03 Astrazeneca Ab Pharmaceutical composition
US8709476B2 (en) 2003-11-04 2014-04-29 Supernus Pharmaceuticals, Inc. Compositions of quaternary ammonium compounds containing bioavailability enhancers
ATE493981T1 (en) * 2003-11-04 2011-01-15 Supernus Pharmaceuticals Inc ONCE DAILY DOSAGE FORMS OF TROSPIUM
US20080033059A1 (en) * 2004-02-19 2008-02-07 Ideal Cures Pvt. Ltd. Enteric Coating Compositions
US20050186271A1 (en) * 2004-02-24 2005-08-25 Sheskey Paul J. Process for dispersing a fluid in a mass of solid particles
TW200602089A (en) * 2004-06-07 2006-01-16 Wyeth Corp Sugar coatings and methods therefor
US8673352B2 (en) 2005-04-15 2014-03-18 Mcneil-Ppc, Inc. Modified release dosage form
WO2008016855A1 (en) * 2006-08-02 2008-02-07 Wm. Wrigley Jr. Company Oral compositions effective for the treatment of oral cavity malodor associated with the consumption of odor-causing compounds
RU2009116424A (en) * 2006-11-07 2010-12-20 Вайет (Us) SUGAR-CONTAINING COATINGS AND METHODS FOR PRODUCING THEM
US20080292683A1 (en) * 2007-05-24 2008-11-27 Monosolrx, Llc. Film shreds and delivery system incorporating same
US20100034959A1 (en) * 2008-08-07 2010-02-11 Vector Corporation High solids, high molecular weight polymer coating
US9149959B2 (en) 2010-10-22 2015-10-06 Monosol Rx, Llc Manufacturing of small film strips
CN105916952B (en) * 2014-03-13 2019-11-12 Dic株式会社 Bonding sheet and electronic equipment
US10434061B2 (en) 2014-12-05 2019-10-08 Societe Des Produits Nestle S.A. Composition and method for orally administering one or more active agents to a pet
CA2937365C (en) 2016-03-29 2018-09-18 F. Hoffmann-La Roche Ag Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same
US11273131B2 (en) 2016-05-05 2022-03-15 Aquestive Therapeutics, Inc. Pharmaceutical compositions with enhanced permeation
BR112018072539A2 (en) 2016-05-05 2019-03-26 Aquestive Therapeutics, Inc. increased administration epinephrine compositions
EP3860849A4 (en) * 2018-10-05 2022-06-22 ISP Investments LLC Smooth high solids film coating composition comprising water soluble cellulose ether, process for preparing the same

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Also Published As

Publication number Publication date
AU7200494A (en) 1995-03-22
US5641513A (en) 1997-06-24
EP0716597A1 (en) 1996-06-19
WO1995006462A1 (en) 1995-03-09
JPH09501947A (en) 1997-02-25
AU680019B2 (en) 1997-07-17
CA2164344C (en) 2004-06-29
US5641536A (en) 1997-06-24

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