CA2165830A1 - Salmeterol xinafoate with controlled particle size - Google Patents
Salmeterol xinafoate with controlled particle sizeInfo
- Publication number
- CA2165830A1 CA2165830A1 CA002165830A CA2165830A CA2165830A1 CA 2165830 A1 CA2165830 A1 CA 2165830A1 CA 002165830 A CA002165830 A CA 002165830A CA 2165830 A CA2165830 A CA 2165830A CA 2165830 A1 CA2165830 A1 CA 2165830A1
- Authority
- CA
- Canada
- Prior art keywords
- particle size
- salmeterol xinafoate
- controlled particle
- relates
- products
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
- B01D11/0411—Solvent extraction of solutions which are liquid with a supercritical fluid the supercritical fluid acting as solvent for the solvent and as anti-solvent for the solute, e.g. formation of particles from solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/08—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom
- C07C217/10—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
Abstract
The invention relates to particulate products which may be prepared by methods and apparatus using supercritical fluids. More particularly the invention relates to pharmaceutical products, in particular easily handled and easily fluidised crystalline forms of salmeterol xinafoate, with controlled particle size and shape.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939313650A GB9313650D0 (en) | 1993-07-01 | 1993-07-01 | Method and apparatus for the formation of particles |
GB9313650.5 | 1993-07-01 | ||
PCT/GB1994/001425 WO1995001324A1 (en) | 1993-07-01 | 1994-06-30 | Salmeterol xinafoate with controlled particle size |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2165830A1 true CA2165830A1 (en) | 1995-01-12 |
CA2165830C CA2165830C (en) | 2005-04-26 |
Family
ID=10738146
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002165830A Expired - Lifetime CA2165830C (en) | 1993-07-01 | 1994-06-30 | Salmeterol xinafoate with controlled particle size |
Country Status (20)
Country | Link |
---|---|
US (1) | US5795594A (en) |
EP (1) | EP0706507B1 (en) |
JP (1) | JP3839042B2 (en) |
CN (1) | CN1062854C (en) |
AT (1) | ATE184870T1 (en) |
AU (1) | AU684795B2 (en) |
BR (1) | BR9406995A (en) |
CA (1) | CA2165830C (en) |
DE (1) | DE69420844T2 (en) |
DK (1) | DK0706507T3 (en) |
ES (1) | ES2138085T3 (en) |
FI (1) | FI956343A (en) |
GB (1) | GB9313650D0 (en) |
GR (1) | GR3032065T3 (en) |
HK (1) | HK1004216A1 (en) |
HU (1) | HUT73733A (en) |
NO (1) | NO304940B1 (en) |
NZ (1) | NZ267696A (en) |
RU (1) | RU2136655C1 (en) |
WO (1) | WO1995001324A1 (en) |
Families Citing this family (77)
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EP0855906B1 (en) * | 1995-10-17 | 2008-02-20 | Jagotec AG | Insoluble drug delivery |
US5833891A (en) * | 1996-10-09 | 1998-11-10 | The University Of Kansas | Methods for a particle precipitation and coating using near-critical and supercritical antisolvents |
US5874029A (en) * | 1996-10-09 | 1999-02-23 | The University Of Kansas | Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent |
US6652837B1 (en) | 1996-05-24 | 2003-11-25 | Massachusetts Institute Of Technology | Preparation of novel particles for inhalation |
US6503480B1 (en) | 1997-05-23 | 2003-01-07 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
US6254854B1 (en) | 1996-05-24 | 2001-07-03 | The Penn Research Foundation | Porous particles for deep lung delivery |
US20020052310A1 (en) * | 1997-09-15 | 2002-05-02 | Massachusetts Institute Of Technology The Penn State Research Foundation | Particles for inhalation having sustained release properties |
GB9622173D0 (en) | 1996-10-24 | 1996-12-18 | Glaxo Group Ltd | Particulate Products |
GB9703673D0 (en) * | 1997-02-21 | 1997-04-09 | Bradford Particle Design Ltd | Method and apparatus for the formation of particles |
US7052678B2 (en) | 1997-09-15 | 2006-05-30 | Massachusetts Institute Of Technology | Particles for inhalation having sustained release properties |
US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
GB9806462D0 (en) * | 1998-03-26 | 1998-05-27 | Glaxo Group Ltd | Improved compositions for inhalation |
GB9808802D0 (en) * | 1998-04-24 | 1998-06-24 | Glaxo Group Ltd | Pharmaceutical formulations |
GB9810559D0 (en) * | 1998-05-15 | 1998-07-15 | Bradford Particle Design Ltd | Method and apparatus for particle formation |
US6956021B1 (en) | 1998-08-25 | 2005-10-18 | Advanced Inhalation Research, Inc. | Stable spray-dried protein formulations |
SE9804001D0 (en) * | 1998-11-23 | 1998-11-23 | Astra Ab | New process |
EP1185248B1 (en) * | 1999-06-09 | 2012-05-02 | Robert E. Sievers | Supercritical fluid-assisted nebulization and bubble drying |
US6858199B1 (en) | 2000-06-09 | 2005-02-22 | Advanced Inhalation Research, Inc. | High efficient delivery of a large therapeutic mass aerosol |
GB9915975D0 (en) * | 1999-07-07 | 1999-09-08 | Bradford Particle Design Ltd | Method for the formation of particles |
WO2001013891A2 (en) * | 1999-08-25 | 2001-03-01 | Advanced Inhalation Research, Inc. | Modulation of release from dry powder formulations |
US7678364B2 (en) | 1999-08-25 | 2010-03-16 | Alkermes, Inc. | Particles for inhalation having sustained release properties |
US6749835B1 (en) | 1999-08-25 | 2004-06-15 | Advanced Inhalation Research, Inc. | Formulation for spray-drying large porous particles |
US20010036481A1 (en) * | 1999-08-25 | 2001-11-01 | Advanced Inhalation Research, Inc. | Modulation of release from dry powder formulations |
FR2798290B1 (en) * | 1999-09-11 | 2003-09-12 | Glaxo Group Ltd | PHARMACEUTICAL FORMULATION OF FLUTICASONE PROPIONATE |
FR2803538B1 (en) * | 1999-12-15 | 2002-06-07 | Separex Sa | METHOD AND DEVICE FOR CAPTURING FINE PARTICLES BY PERCOLATION IN A BED OF GRANULES |
US6761909B1 (en) | 1999-12-21 | 2004-07-13 | Rxkinetix, Inc. | Particulate insulin-containing products and method of manufacture |
AU2729101A (en) | 1999-12-21 | 2001-07-03 | Rxkinetix, Inc. | Particulate drug-containing products and method of manufacture |
US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
GB0015981D0 (en) * | 2000-06-29 | 2000-08-23 | Glaxo Group Ltd | Novel process for preparing crystalline particles |
US8551526B2 (en) * | 2000-11-03 | 2013-10-08 | Board Of Regents, The University Of Texas System | Preparation of drug particles using evaporation precipitation into aqueous solutions |
US6756062B2 (en) | 2000-11-03 | 2004-06-29 | Board Of Regents University Of Texas System | Preparation of drug particles using evaporation precipitation into aqueous solutions |
GB0027357D0 (en) | 2000-11-09 | 2000-12-27 | Bradford Particle Design Plc | Particle formation methods and their products |
AU2002230993B2 (en) * | 2000-12-29 | 2006-02-02 | Alkermes, Inc. | Particles for inhalation having sustained release properties |
US20020141946A1 (en) * | 2000-12-29 | 2002-10-03 | Advanced Inhalation Research, Inc. | Particles for inhalation having rapid release properties |
BR0207570B1 (en) * | 2001-02-26 | 2013-02-05 | apparatus for forming micronized and submicronised particles of a substance, nozzle, and process performed using the apparatus. | |
EP1414633A4 (en) * | 2001-07-10 | 2005-01-26 | Univ Technology Corp | Devices and methods for the production of particles |
GB0117403D0 (en) * | 2001-07-17 | 2001-09-05 | Pharmacia & Upjohn Spa | Solvent-free crystalline anthracycline derivatives |
GB0208742D0 (en) | 2002-04-17 | 2002-05-29 | Bradford Particle Design Ltd | Particulate materials |
GB0117696D0 (en) * | 2001-07-20 | 2001-09-12 | Bradford Particle Design Plc | Particle information |
NZ532759A (en) * | 2001-10-10 | 2005-10-28 | Boehringer Ingelheim Pharma | Powder processing with pressurized gaseous fluids |
WO2003043603A1 (en) * | 2001-11-20 | 2003-05-30 | Advanced Inhalation Research, Inc. | Particulate compositions for improving solubility of poorly soluble agents |
CA2465675C (en) * | 2001-11-20 | 2008-06-10 | Advanced Inhalation Research, Inc. | Improved particulate compositions for pulmonary delivery |
ES2364636T3 (en) | 2001-12-19 | 2011-09-08 | Novartis Ag | PULMONARY ADMINISTRATION OF AMINOGLUCOSIDS. |
US20050163725A1 (en) * | 2002-03-20 | 2005-07-28 | Blizzard Charles D. | Method for administration of growth hormone via pulmonary delivery |
US7008644B2 (en) * | 2002-03-20 | 2006-03-07 | Advanced Inhalation Research, Inc. | Method and apparatus for producing dry particles |
JP2005521695A (en) * | 2002-03-20 | 2005-07-21 | アドバンスト インハレーション リサーチ,インコーポレイテッド | Method of administering growth hormone by pulmonary delivery |
GB0216562D0 (en) | 2002-04-25 | 2002-08-28 | Bradford Particle Design Ltd | Particulate materials |
WO2003090715A2 (en) * | 2002-04-25 | 2003-11-06 | Nektar Therapeutics Uk Ltd | Particulate materials |
US9339459B2 (en) | 2003-04-24 | 2016-05-17 | Nektar Therapeutics | Particulate materials |
US20040202681A1 (en) * | 2002-12-19 | 2004-10-14 | Baxter International, Inc. | Process for preparing pharmaceutical formulations using supercritical fluids |
DE10351663A1 (en) * | 2002-12-20 | 2004-07-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Stable, accurately dosable inhalable powder medicament for treating asthma or chronic obstructive pulmonary disease, containing tiotropium, specific form of salmeterol xinafoate and auxiliary |
US20040152720A1 (en) * | 2002-12-20 | 2004-08-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Powdered medicaments containing a tiotropium salt and salmeterol xinafoate |
MXPA05007154A (en) * | 2002-12-30 | 2005-09-21 | Nektar Therapeutics | Prefilming atomizer. |
US6915966B2 (en) * | 2003-01-29 | 2005-07-12 | Specialty Minerals (Michigan) Inc. | Apparatus for the gunning of a refractory material and nozzles for same |
MY147403A (en) * | 2003-04-29 | 2012-11-30 | Kowa Co | Composition containing medicine extremely slightly solube in water and method for preparation thereof |
AU2004237131B2 (en) | 2003-05-08 | 2009-09-10 | Nektar Therapeutics | Particulate materials |
JP4206317B2 (en) * | 2003-09-10 | 2009-01-07 | 花王株式会社 | Method for producing organic plate-like particles |
GB0327723D0 (en) | 2003-09-15 | 2003-12-31 | Vectura Ltd | Pharmaceutical compositions |
EP1949891A1 (en) | 2004-10-12 | 2008-07-30 | Generics (UK) Limited | Process for the preparation of suspension aerosol formulations, wherein the particles are formed by precipitation inside an aerosol canister |
US9808423B2 (en) * | 2004-10-12 | 2017-11-07 | Generics [Uk] Limited | Preparation of suspension aerosol formulations |
US7854397B2 (en) * | 2005-01-21 | 2010-12-21 | Specialty Minerals (Michigan) Inc. | Long throw shotcrete nozzle |
WO2007009164A1 (en) | 2005-07-15 | 2007-01-25 | Eiffel Technologies Limited | Method of particle formation |
US20070021605A1 (en) * | 2005-07-20 | 2007-01-25 | Rolf Keltjens | Process and composition for making olanzapine form i |
WO2007020080A1 (en) * | 2005-08-17 | 2007-02-22 | Synthon B.V. | A process for making olanzapine form i |
WO2007067566A2 (en) * | 2005-12-07 | 2007-06-14 | Wyeth | Methods for preparing crystalline rapamycin and for measuring crystallinity of rapamycin compounds using differential scanning calorimetry |
US20070293479A1 (en) * | 2006-05-18 | 2007-12-20 | Osinga Niels J | Olanzapine pharmaceutical composition |
CL2007002807A1 (en) * | 2006-09-29 | 2008-04-11 | Synthon Bv | PHARMACEUTICAL COMPOSITION IN SOLID STATE THAT INCLUDES OLANZAPINE OR A PHARMACEUTICALLY ACCEPTABLE SALT OF THE SAME AND LACTOSE ANHYDRA; ORAL PHARMACEUTICAL TABLET; PROCEDURE FOR PREPARATION OF SUCH TABLET, USEFUL IN THE TREATMENT OF SKI |
CN1973812B (en) * | 2006-11-03 | 2010-12-08 | 谭登平 | Method of powdering supercritical CO2 solid extract |
CN104188907A (en) | 2007-02-11 | 2014-12-10 | Map药物公司 | Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile |
EP2127641A1 (en) * | 2008-05-26 | 2009-12-02 | Inke, S.A. | Micronisable form of salmeterol xinafoate |
WO2012032546A2 (en) | 2010-09-08 | 2012-03-15 | Cadila Healthcare Limited | Process for the preparation of salmeterol and its intermediates |
MX350838B (en) | 2011-02-11 | 2017-09-18 | Grain Proc Corporation * | Salt composition. |
US9908062B2 (en) | 2012-11-20 | 2018-03-06 | Andrew Paul Joseph | Extraction apparatus and method |
US9132363B2 (en) | 2012-11-20 | 2015-09-15 | Apeks Llc | Extraction system |
JP2021141003A (en) * | 2020-03-07 | 2021-09-16 | エムテックスマート株式会社 | Manufacturing method of secondary battery or secondary battery |
WO2021219230A1 (en) | 2020-04-30 | 2021-11-04 | Paolo Fiorina | Antiviral treatment |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3744329A1 (en) * | 1987-12-28 | 1989-07-06 | Schwarz Pharma Gmbh | METHOD FOR THE PRODUCTION OF AT LEAST ONE ACTIVE AGENT AND A TRAITER COMPRISING PREPARATION |
AU663906B2 (en) * | 1991-12-12 | 1995-10-26 | Glaxo Group Limited | Medicaments |
US5509404A (en) * | 1994-07-11 | 1996-04-23 | Aradigm Corporation | Intrapulmonary drug delivery within therapeutically relevant inspiratory flow/volume values |
-
1993
- 1993-07-01 GB GB939313650A patent/GB9313650D0/en active Pending
-
1994
- 1994-06-30 HU HU9503772A patent/HUT73733A/en unknown
- 1994-06-30 DK DK94918982T patent/DK0706507T3/en active
- 1994-06-30 RU RU96102011A patent/RU2136655C1/en active
- 1994-06-30 US US08/564,278 patent/US5795594A/en not_active Expired - Lifetime
- 1994-06-30 AU AU70070/94A patent/AU684795B2/en not_active Ceased
- 1994-06-30 CA CA002165830A patent/CA2165830C/en not_active Expired - Lifetime
- 1994-06-30 CN CN94193201A patent/CN1062854C/en not_active Expired - Lifetime
- 1994-06-30 EP EP94918982A patent/EP0706507B1/en not_active Expired - Lifetime
- 1994-06-30 ES ES94918982T patent/ES2138085T3/en not_active Expired - Lifetime
- 1994-06-30 WO PCT/GB1994/001425 patent/WO1995001324A1/en active IP Right Grant
- 1994-06-30 BR BR9406995A patent/BR9406995A/en not_active Application Discontinuation
- 1994-06-30 DE DE69420844T patent/DE69420844T2/en not_active Expired - Lifetime
- 1994-06-30 AT AT94918982T patent/ATE184870T1/en not_active IP Right Cessation
- 1994-06-30 JP JP50336895A patent/JP3839042B2/en not_active Expired - Lifetime
- 1994-06-30 NZ NZ267696A patent/NZ267696A/en not_active IP Right Cessation
-
1995
- 1995-12-29 FI FI956343A patent/FI956343A/en unknown
- 1995-12-29 NO NO19955355A patent/NO304940B1/en not_active IP Right Cessation
-
1998
- 1998-04-23 HK HK98103417A patent/HK1004216A1/en not_active IP Right Cessation
-
1999
- 1999-12-07 GR GR990403154T patent/GR3032065T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP0706507B1 (en) | 1999-09-22 |
CN1062854C (en) | 2001-03-07 |
NO955355D0 (en) | 1995-12-29 |
ATE184870T1 (en) | 1999-10-15 |
DE69420844T2 (en) | 2000-03-16 |
AU7007094A (en) | 1995-01-24 |
FI956343A (en) | 1996-02-15 |
DK0706507T3 (en) | 2000-04-10 |
NZ267696A (en) | 1997-11-24 |
ES2138085T3 (en) | 2000-01-01 |
FI956343A0 (en) | 1995-12-29 |
HU9503772D0 (en) | 1996-02-28 |
JP3839042B2 (en) | 2006-11-01 |
WO1995001324A1 (en) | 1995-01-12 |
EP0706507A1 (en) | 1996-04-17 |
GR3032065T3 (en) | 2000-03-31 |
NO955355L (en) | 1996-02-29 |
DE69420844D1 (en) | 1999-10-28 |
CA2165830C (en) | 2005-04-26 |
US5795594A (en) | 1998-08-18 |
HUT73733A (en) | 1996-09-30 |
BR9406995A (en) | 1996-09-10 |
GB9313650D0 (en) | 1993-08-18 |
HK1004216A1 (en) | 1998-11-20 |
AU684795B2 (en) | 1998-01-08 |
RU2136655C1 (en) | 1999-09-10 |
CN1129932A (en) | 1996-08-28 |
JPH08512047A (en) | 1996-12-17 |
NO304940B1 (en) | 1999-03-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20140630 |