CA2167822A1 - Potentiometric biosensor and the method for its use - Google Patents

Potentiometric biosensor and the method for its use

Info

Publication number
CA2167822A1
CA2167822A1 CA002167822A CA2167822A CA2167822A1 CA 2167822 A1 CA2167822 A1 CA 2167822A1 CA 002167822 A CA002167822 A CA 002167822A CA 2167822 A CA2167822 A CA 2167822A CA 2167822 A1 CA2167822 A1 CA 2167822A1
Authority
CA
Canada
Prior art keywords
reagent
fluid sample
analyze
enzyme
potentiometric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002167822A
Other languages
French (fr)
Other versions
CA2167822C (en
Inventor
Kent M. Kost
Thomas J. Lindsay
John F. Price
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics Operations Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2167822A1 publication Critical patent/CA2167822A1/en
Application granted granted Critical
Publication of CA2167822C publication Critical patent/CA2167822C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/004—Enzyme electrodes mediator-assisted
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/817—Enzyme or microbe electrode

Abstract

A potentiometric biosensor, test strip, reagent, and a potentiometric method for detection or measurement of an analyte from a fluid sample. The biosensor includes indicating (3) and reference electrodes, (5), and a reagent (9), which overlays a portion of the surface of the indicating electrode (3). The reagent generally includes an enzyme and a redox mediator. When a fluid sample (e.g., blood) containing an analyte (e.g., glucose) is added to the reagent, the enzyme (e.g., glucose oxidase) catalyses a reaction involving enzyme, redox mediator (e.g., potassium ferricyanide), and analyze. This reaction may be monitored by monitoring the electrical potential at the indicating electrode surface. The inventive potentiometric biosensor measures the change in potential at the indicating electrode surface after the fluid sample containing the analyze is added to the reagent. The change in potential that occurs may be correlated to the detection or measurement of analyze in the fluid sample.
CA002167822A 1993-07-23 1994-07-21 Potentiometric biosensor and the method for its use Expired - Fee Related CA2167822C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/097,331 1993-07-23
US08/097,331 US5413690A (en) 1993-07-23 1993-07-23 Potentiometric biosensor and the method of its use
PCT/US1994/008236 WO1995003543A1 (en) 1993-07-23 1994-07-21 Potentiometric biosensor and the method of its use

Publications (2)

Publication Number Publication Date
CA2167822A1 true CA2167822A1 (en) 1995-02-02
CA2167822C CA2167822C (en) 2004-02-24

Family

ID=22262812

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002167822A Expired - Fee Related CA2167822C (en) 1993-07-23 1994-07-21 Potentiometric biosensor and the method for its use

Country Status (7)

Country Link
US (1) US5413690A (en)
EP (1) EP0710358B1 (en)
JP (1) JP3387926B2 (en)
CA (1) CA2167822C (en)
DE (1) DE69427353T2 (en)
ES (1) ES2158900T3 (en)
WO (1) WO1995003543A1 (en)

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