CA2169852A1 - Self-addressable self-assembling microelectronic systems and devices for molecular biological analysis and diagnostics - Google Patents

Self-addressable self-assembling microelectronic systems and devices for molecular biological analysis and diagnostics

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Publication number
CA2169852A1
CA2169852A1 CA002169852A CA2169852A CA2169852A1 CA 2169852 A1 CA2169852 A1 CA 2169852A1 CA 002169852 A CA002169852 A CA 002169852A CA 2169852 A CA2169852 A CA 2169852A CA 2169852 A1 CA2169852 A1 CA 2169852A1
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CA
Canada
Prior art keywords
self
molecular biological
reactions
control
analytes
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Granted
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CA002169852A
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French (fr)
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CA2169852C (en
Inventor
Michael J. Heller
Eugene Tu
Glen A. Evans
Ronald G. Sosnowski
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Gamida for Life BV
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Individual
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    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
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    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25125—Digestion or removing interfering materials

Abstract

A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridizations, antibody/antigen reactions, diagnostics, and biopolymer synthesis. The device can be fabricated using both microlithographic and micro-machining techniques.
The device can electronically control the transport and attachment of specific binding entities to specific micro-locations. The specific binding entities include molecular biological molecules such as nucleic acids and polypeptides. The device can subsequently control the transport and reaction of analytes or reactants at the addressed specific micro-locations. The device is able to concentrate analytes and reactants, remove non-specifically bound molecules, provide stringency control for DNA hybridization reactions, and improve the detection of analytes. The device can be electronically replicated.
CA002169852A 1994-07-07 1995-07-05 Self-addressable self-assembling microelectronic systems and devices for molecular biological analysis and diagnostics Expired - Fee Related CA2169852C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/271,882 US6017696A (en) 1993-11-01 1994-07-07 Methods for electronic stringency control for molecular biological analysis and diagnostics
US08/271,882 1994-07-07
PCT/US1995/008570 WO1996001836A1 (en) 1994-07-07 1995-07-05 Self-addressable self-assembling microelectronic systems and devices for molecular biological analysis and diagnostics

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CA2169852A1 true CA2169852A1 (en) 1996-01-25
CA2169852C CA2169852C (en) 2008-09-23

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EP (1) EP0717749B1 (en)
JP (2) JPH09503307A (en)
CN (2) CN1550556A (en)
AT (1) ATE232604T1 (en)
AU (1) AU708677B2 (en)
BR (1) BR9506035A (en)
CA (1) CA2169852C (en)
DE (1) DE69529601D1 (en)
FI (1) FI961034A (en)
HK (1) HK1011080A1 (en)
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WO (1) WO1996001836A1 (en)

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