CA2170660A1 - Method and apparatus for reduction of bias in amperometric sensors - Google Patents

Method and apparatus for reduction of bias in amperometric sensors

Info

Publication number
CA2170660A1
CA2170660A1 CA002170660A CA2170660A CA2170660A1 CA 2170660 A1 CA2170660 A1 CA 2170660A1 CA 002170660 A CA002170660 A CA 002170660A CA 2170660 A CA2170660 A CA 2170660A CA 2170660 A1 CA2170660 A1 CA 2170660A1
Authority
CA
Canada
Prior art keywords
analyte
potential
test sample
concentration
fluid test
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002170660A
Other languages
French (fr)
Other versions
CA2170660C (en
Inventor
Marvin A. Genshaw
Dijia Huang
Matthew K. Musho
Kin-Fai Yip
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ascensia Diabetes Care Holdings AG
Original Assignee
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23730666&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2170660(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Corp filed Critical Bayer Corp
Priority to CA002416606A priority Critical patent/CA2416606C/en
Publication of CA2170660A1 publication Critical patent/CA2170660A1/en
Application granted granted Critical
Publication of CA2170660C publication Critical patent/CA2170660C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/004—Enzyme electrodes mediator-assisted

Abstract

Apparatus and method are provided for determining the concentration of an analyte in a fluid test sample by applying the fluid test sample to the surface of a work- ing electrode which is electrochemically connected to a reference electrode which surface bears a composition comprising an enzyme specific for the analyte. A media- tor is reduced in response to a reaction between the ana- lyte and the enzyme. An oxidizing potential is applied between the electrodes to return at least a portion of the mediator back to its oxidized form before determining the concentration of the analyte to thereby increase the accuracy of the analyte determination. Following this initially applied potential, the circuit is switched to an open circuit or to a potential that substantially re- duces the current to minimize the rate of electrochemical potential at the working electrode. A second potential is applied between the electrodes and the current gener- ated in the fluid test sample is measured to determine analyte concentration. Optionally, the accuracy of the analyte determination is further enhanced algorithmi- cally.
CA002170660A 1995-05-05 1996-02-29 Method and apparatus for reduction of bias in amperometric sensors Expired - Lifetime CA2170660C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002416606A CA2416606C (en) 1995-05-05 1996-02-29 Apparatus and method for reduction of bias in amperometric sensors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/435,993 1995-05-05
US08/435,993 US5620579A (en) 1995-05-05 1995-05-05 Apparatus for reduction of bias in amperometric sensors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002416606A Division CA2416606C (en) 1995-05-05 1996-02-29 Apparatus and method for reduction of bias in amperometric sensors

Publications (2)

Publication Number Publication Date
CA2170660A1 true CA2170660A1 (en) 1996-11-06
CA2170660C CA2170660C (en) 2004-06-08

Family

ID=23730666

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002170660A Expired - Lifetime CA2170660C (en) 1995-05-05 1996-02-29 Method and apparatus for reduction of bias in amperometric sensors

Country Status (9)

Country Link
US (2) US5620579A (en)
EP (1) EP0741186B1 (en)
JP (1) JP3413323B2 (en)
AT (1) ATE207113T1 (en)
AU (1) AU701303B2 (en)
CA (1) CA2170660C (en)
DE (1) DE69615909T2 (en)
DK (1) DK0741186T3 (en)
ES (1) ES2162643T3 (en)

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