CA2173594A1 - Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo - Google Patents
Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivoInfo
- Publication number
- CA2173594A1 CA2173594A1 CA002173594A CA2173594A CA2173594A1 CA 2173594 A1 CA2173594 A1 CA 2173594A1 CA 002173594 A CA002173594 A CA 002173594A CA 2173594 A CA2173594 A CA 2173594A CA 2173594 A1 CA2173594 A1 CA 2173594A1
- Authority
- CA
- Canada
- Prior art keywords
- vivo
- bioreactor
- compositions
- methods
- hollow fiber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0684—Cells of the urinary tract or kidneys
- C12N5/0687—Renal stem cells; Renal progenitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/022—Artificial gland structures using bioreactors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/06—Tubular
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/02—Membranes; Filters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/16—Hollow fibers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/069—Vascular Endothelial cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/25—Urinary tract cells, renal cells
- C12N2502/256—Renal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/28—Vascular endothelial cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/54—Collagen; Gelatin
Abstract
A novel cell seeded hollow fiber bioreactor is described as a potential bioartifical kidney. Renal cells are seeded along a hollow fiber (10) in a perfused bioreactor to reproduce the ultrafiltration function and transport function of the kidney.
Maintenance of tissue specific function and ultrastructure suggest that this bioreactor provides an economical device for treating renal failure as well as studying renal tubululogenesis in vitro.
Maintenance of tissue specific function and ultrastructure suggest that this bioreactor provides an economical device for treating renal failure as well as studying renal tubululogenesis in vitro.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2469481A CA2469481C (en) | 1993-10-08 | 1994-10-11 | Growing renal tubule cells and ex vivo renal tubule tissue system |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/133,436 US5549674A (en) | 1992-03-02 | 1993-10-08 | Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo |
US133,436 | 1993-10-08 | ||
PCT/US1994/011384 WO1995011048A2 (en) | 1993-10-08 | 1994-10-11 | METHODS AND COMPOSITIONS OF A BIOARTIFICIAL KIDNEY SUITABLE FOR USE IN VIVO OR $i(EX VIVO) |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2469481A Division CA2469481C (en) | 1993-10-08 | 1994-10-11 | Growing renal tubule cells and ex vivo renal tubule tissue system |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2173594A1 true CA2173594A1 (en) | 1995-04-27 |
CA2173594C CA2173594C (en) | 2004-09-07 |
Family
ID=22458619
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2710965A Expired - Fee Related CA2710965C (en) | 1993-10-08 | 1994-10-11 | Growing renal tubule cells and ex vivo renal tubule tissue system |
CA002173594A Expired - Fee Related CA2173594C (en) | 1993-10-08 | 1994-10-11 | Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2710965A Expired - Fee Related CA2710965C (en) | 1993-10-08 | 1994-10-11 | Growing renal tubule cells and ex vivo renal tubule tissue system |
Country Status (8)
Country | Link |
---|---|
US (2) | US5549674A (en) |
EP (1) | EP0746343B1 (en) |
JP (2) | JP3614853B2 (en) |
AT (1) | ATE257018T1 (en) |
AU (1) | AU692191B2 (en) |
CA (2) | CA2710965C (en) |
DE (1) | DE69433464T2 (en) |
WO (1) | WO1995011048A2 (en) |
Families Citing this family (115)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6410320B1 (en) | 1992-03-02 | 2002-06-25 | The University Of Michigan | Method and compositions for isolation and growth of kidney tubule stem cells, in vitro kidney tubulogenesis and ex vivo construction of renal tubules |
SE9900043D0 (en) * | 1999-01-11 | 1999-01-11 | Astra Ab | New use |
AU2399495A (en) * | 1994-04-29 | 1995-11-29 | W.L. Gore & Associates, Inc. | Improved blood contact surfaces using endothelium on a subendothelial extracellular matrix |
US6152141A (en) * | 1994-07-28 | 2000-11-28 | Heartport, Inc. | Method for delivery of therapeutic agents to the heart |
WO1997012960A2 (en) * | 1995-10-06 | 1997-04-10 | Academisch Ziekenhuis Bij De Universiteit Van Amsterdam | Solid support for use in cell cultivation, especially for the cultivation of liver cells, biological reactor containing said solid support and the use thereof in a bio-artificial liver system |
WO1998009582A1 (en) * | 1996-09-05 | 1998-03-12 | Children's Medical Center Corporation | Prosthetic kidney and its use for treating kidney disease |
US6673339B1 (en) | 1996-09-05 | 2004-01-06 | Children's Medical Center Corporation | Prosthetic kidney and its use for treating kidney disease |
US6150164A (en) * | 1996-09-30 | 2000-11-21 | The Regents Of The University Of Michigan | Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo |
US5902336A (en) * | 1996-10-15 | 1999-05-11 | Mirimedical, Inc. | Implantable device and method for removing fluids from the blood of a patient method for implanting such a device and method for treating a patient experiencing renal failure |
ATE248615T1 (en) * | 1997-10-31 | 2003-09-15 | Childrens Medical Center | BLADDER RECONSTRUCTION |
DE69834836T2 (en) | 1997-10-31 | 2007-05-16 | Children's Medical Center Corp., Boston | PENIS RECONSTRUCTION |
WO2000061630A1 (en) * | 1999-04-08 | 2000-10-19 | President And Fellows Of Harvard College | Induction of kidney tubule formation |
JP4347528B2 (en) * | 1999-04-23 | 2009-10-21 | ネフリオン, インコーポレイテッド | Extracorporeal circuit and related methods |
AU2004201641B2 (en) * | 1999-04-30 | 2007-04-19 | The Charles Stark Draper Laboratory, Inc. | Fabrication of Vascularized Tissue Using Microfabricated Two-Dimensional Molds |
JP2002542883A (en) | 1999-04-30 | 2002-12-17 | マサチューセッツ ジェネラル ホスピタル | Processing of neovascularized tissue using microfabricated two-dimensional mold |
US7759113B2 (en) | 1999-04-30 | 2010-07-20 | The General Hospital Corporation | Fabrication of tissue lamina using microfabricated two-dimensional molds |
US20040167634A1 (en) * | 1999-05-26 | 2004-08-26 | Anthony Atala | Prosthetic kidney and its use for treating kidney disease |
JP3229599B2 (en) * | 1999-06-01 | 2001-11-19 | ホスパル株式会社 | Blood purification device and artificial kidney using it |
EP1206284B1 (en) * | 1999-08-10 | 2007-07-11 | Innovata PLC | Method for delivery of therapeutic agents using a solution of dextrin |
DE19943205C1 (en) * | 1999-09-10 | 2000-11-16 | Geesthacht Gkss Forschung | Production, transport and elimination of biochemical substances using an apparatus comprising cells immobilized in polar orientation between two membranes, e.g. for use as a biohybrid organ |
US6479064B1 (en) | 1999-12-29 | 2002-11-12 | Children's Medical Center Corporation | Culturing different cell populations on a decellularized natural biostructure for organ reconstruction |
US6924141B2 (en) * | 2000-03-31 | 2005-08-02 | The General Hospital Corporation | Methods of modulating hair growth |
US7776021B2 (en) * | 2000-04-28 | 2010-08-17 | The Charles Stark Draper Laboratory | Micromachined bilayer unit for filtration of small molecules |
EP2044965B1 (en) * | 2000-10-12 | 2012-12-19 | Renal Solutions, Inc. | Apparatus for body fluid flow control in extracorporeal fluid treatments |
US6538010B1 (en) * | 2000-11-08 | 2003-03-25 | Research Triangle Institute | Compounds and methods for promoting smoking cessation |
US7033498B2 (en) * | 2000-11-28 | 2006-04-25 | Renal Solutions, Inc. | Cartridges useful in cleaning dialysis solutions |
US6627164B1 (en) * | 2000-11-28 | 2003-09-30 | Renal Solutions, Inc. | Sodium zirconium carbonate and zirconium basic carbonate and methods of making the same |
WO2002055136A2 (en) * | 2000-12-01 | 2002-07-18 | Nephros Therapeutics Inc | Intrasvascular drug delivery device and use therefor |
US6659973B2 (en) * | 2001-01-04 | 2003-12-09 | Transvivo, Inc. | Apparatus and method for in-vivo plasmapheresis using periodic backflush |
US7476210B2 (en) * | 2001-01-04 | 2009-01-13 | Transvivo Inc. | Apparatus and method for in-vivo plasmapheresis using periodic backflush containing anticoagulant |
US6582955B2 (en) * | 2001-05-11 | 2003-06-24 | Spectrum Laboratories, Inc. | Bioreactor with application as blood therapy device |
KR100864648B1 (en) * | 2001-05-17 | 2008-10-23 | 가부시키가이샤 가네카 | Artificial kidney having function of metabolizing protein and method of constructing the same |
US6653131B2 (en) * | 2001-08-30 | 2003-11-25 | The Regents Of The University Of Michigan | Method of treating systemic inflammatory response syndrome |
US7332330B2 (en) * | 2001-09-11 | 2008-02-19 | Renamed Biologics, Inc. | Device for maintaining vascularization near an implant |
AU2002340463A1 (en) * | 2001-11-16 | 2003-06-10 | Children's Medical Center Corporation | Augmentation of organ function |
US6878283B2 (en) * | 2001-11-28 | 2005-04-12 | Renal Solutions, Inc. | Filter cartridge assemblies and methods for filtering fluids |
US7514075B2 (en) * | 2001-12-07 | 2009-04-07 | Cytori Therapeutics, Inc. | Systems and methods for separating and concentrating adipose derived stem cells from tissue |
US20050095228A1 (en) | 2001-12-07 | 2005-05-05 | Fraser John K. | Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders |
WO2006075986A1 (en) * | 2005-01-10 | 2006-07-20 | Macropore Biosurgery, Inc. | Devices and methods for monitoring, managing, and servicing medical devices |
CN1630526B (en) | 2001-12-07 | 2010-05-05 | 马克罗珀尔生物外科公司 | Systems and methods for treating patients with processed lipoaspirate cells |
US20050008626A1 (en) * | 2001-12-07 | 2005-01-13 | Fraser John K. | Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions |
US7651684B2 (en) | 2001-12-07 | 2010-01-26 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in augmenting autologous fat transfer |
US7595043B2 (en) * | 2001-12-07 | 2009-09-29 | Cytori Therapeutics, Inc. | Method for processing and using adipose-derived stem cells |
US7585670B2 (en) * | 2001-12-07 | 2009-09-08 | Cytori Therapeutics, Inc. | Automated methods for isolating and using clinically safe adipose derived regenerative cells |
US7771716B2 (en) | 2001-12-07 | 2010-08-10 | Cytori Therapeutics, Inc. | Methods of using regenerative cells in the treatment of musculoskeletal disorders |
US8404229B2 (en) * | 2001-12-07 | 2013-03-26 | Cytori Therapeutics, Inc. | Methods of using adipose derived stem cells to treat acute tubular necrosis |
US20050048036A1 (en) * | 2001-12-07 | 2005-03-03 | Hedrick Marc H. | Methods of using regenerative cells in the treatment of inherited and acquired disorders of the bone, bone marrow, liver, and other tissues |
US8105580B2 (en) | 2001-12-07 | 2012-01-31 | Cytori Therapeutics, Inc. | Methods of using adipose derived stem cells to promote wound healing |
US7442546B2 (en) * | 2002-03-15 | 2008-10-28 | The Regents Of The University Of Michigan | Method of modulating inflammatory response |
EP1545749A4 (en) * | 2002-09-11 | 2009-03-18 | Univ Michigan | Ultrafiltration membrane, device, bioartificial organ and methods |
WO2004065616A2 (en) | 2003-01-16 | 2004-08-05 | The General Hospital Corporation | Use of three-dimensional microfabricated tissue engineered systems for pharmacologic applications |
US7960166B2 (en) | 2003-05-21 | 2011-06-14 | The General Hospital Corporation | Microfabricated compositions and processes for engineering tissues containing multiple cell types |
US7998101B2 (en) * | 2003-07-28 | 2011-08-16 | Renal Solutions, Inc. | Devices and methods for body fluid flow control in extracorporeal fluid treatment |
AU2004269409A1 (en) * | 2003-08-29 | 2005-03-10 | Regents Of The University Of Minnesota | Kidney derived stem cells and methods for their isolation, differentiation and use |
JP2007530016A (en) * | 2004-02-27 | 2007-11-01 | ザ ジェネラル ホスピタル コーポレーション | Methods and compositions for hair growth |
DE102004017476B4 (en) * | 2004-04-08 | 2009-03-26 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Process for the preparation of a cell composition containing epithelial cells |
EP1778834B9 (en) * | 2004-07-01 | 2011-11-09 | Cytori Therapeutics, Inc. | Methods of using regenerative cells in the treatment of renal diseases and disorders |
US7083653B2 (en) * | 2004-08-12 | 2006-08-01 | Charles Edward Jennings | Implantable human kidney replacement unit |
US9427496B2 (en) | 2005-02-18 | 2016-08-30 | Drexel University | Method for creating an internal transport system within tissue scaffolds using computer-aided tissue engineering |
US7874998B2 (en) * | 2005-11-04 | 2011-01-25 | The Regents Of The University Of Michigan | Filtration devices and related methods thereof |
US8764697B2 (en) | 2006-02-01 | 2014-07-01 | Agathos Holdings Llc | Systems and methods for an advanced medical device |
US8096967B2 (en) * | 2006-02-02 | 2012-01-17 | Milan Radojicic | Tissue engineered cerebrospinal fluid shunt |
CA2637686A1 (en) | 2006-02-02 | 2007-08-16 | Innovative Bio Therapies | An extracorporeal cell-based therapeutic device and delivery system |
US8715221B2 (en) * | 2006-03-08 | 2014-05-06 | Fresenius Medical Care Holdings, Inc. | Wearable kidney |
US8012118B2 (en) * | 2006-03-08 | 2011-09-06 | Fresenius Medical Care Holdings, Inc. | Artificial kidney dialysis system |
US20080090765A1 (en) * | 2006-05-25 | 2008-04-17 | The Trustees Of Columbia University In The City Of New York | Compositions for modulating growth of embryonic and adult kidney tissue and uses for treating kidney damage |
US20080045611A1 (en) * | 2006-08-17 | 2008-02-21 | Milan Radojicic | Methods for the therapeutic use of a carbonic anhydrase inhibitor for reducing spinal cord edema |
US10478555B2 (en) | 2006-08-17 | 2019-11-19 | Milan Radojicic | Systems and methods for lumbar cerebrospinal fluid access and treatment |
US9770180B2 (en) * | 2006-08-17 | 2017-09-26 | Milan Radojicic | System and method for monitoring and delivering therapeutics to the spinal cord |
DE102006042732B3 (en) * | 2006-09-12 | 2008-04-10 | Gerlach, Jörg, Dr.med. | Artificial capillary membrane system for wound treatment, comprises a capillary hollow fiber membrane system having a common inlet and outlet connected with a pumping device and a fluid media feed pump arranged in the capillary system |
WO2008060788A2 (en) | 2006-10-11 | 2008-05-22 | The General Hospital Corporation | Compositions, methods, and devices for treating liver disease |
JP4672632B2 (en) * | 2006-10-17 | 2011-04-20 | 学校法人東海大学 | Bioartificial glomerulus |
JP5166275B2 (en) * | 2006-10-17 | 2013-03-21 | 学校法人東海大学 | Bioartificial tubule |
EP2125171A4 (en) | 2007-01-10 | 2012-05-16 | Univ Michigan | Ultrafiltration membrane, device, bioartificial organ, and related methods |
WO2008109668A2 (en) * | 2007-03-05 | 2008-09-12 | Caridianbct, Inc. | Methods to control cell movement in hollow fiber bioreactors |
US10590391B2 (en) * | 2007-06-08 | 2020-03-17 | Wake Forest University Health Sciences | Selective cell therapy for the treatment of renal failure |
AU2008262333B2 (en) * | 2007-06-08 | 2014-07-17 | Wake Forest University Health Sciences | Selective cell therapy for the treatment of renal failure |
CA2728215A1 (en) | 2008-06-18 | 2010-06-24 | Innovative Biotherapies, Inc. | Methods for enhanced propagation of cells |
US9463276B2 (en) | 2008-08-16 | 2016-10-11 | Milan Radojicic | Systems and methods for a computational medical device in dynamic body systems |
WO2010021993A1 (en) | 2008-08-19 | 2010-02-25 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease |
EP2177603A1 (en) | 2008-09-25 | 2010-04-21 | Gambro Lundia AB | Device for renal cell expansion |
EP2168668A1 (en) | 2008-09-25 | 2010-03-31 | Gambro Lundia AB | Membrane for cell expansion |
EP2168666A1 (en) | 2008-09-25 | 2010-03-31 | Gambro Lundia AB | Irradiated membrane for cell expansion |
ATE545440T1 (en) | 2008-09-25 | 2012-03-15 | Gambro Lundia Ab | HYBRID BIOLOGICAL ARTIFICIAL KIDNEY |
EP2344220B1 (en) * | 2008-11-03 | 2013-04-24 | Fresenius Medical Care Holdings, Inc. | Portable peritoneal dialysis system |
WO2010052705A1 (en) * | 2008-11-06 | 2010-05-14 | Morris Laster | Blood filtering device and method |
CN102271692B (en) * | 2008-11-12 | 2014-05-21 | 坦吉恩股份有限公司 | Isolated renal cells and uses thereof |
WO2010057015A1 (en) * | 2008-11-14 | 2010-05-20 | Wake Forest University Health Sciences | Kidney structures and methods of forming the same |
US20110236874A1 (en) * | 2008-12-02 | 2011-09-29 | Daniele Zink | Method for formation of renal tubules |
WO2010127310A1 (en) | 2009-05-01 | 2010-11-04 | Cytori Therapeutics, Inc. | Systems, methods and compositions for optimizing tissue and cell enriched grafts |
WO2011140231A1 (en) | 2010-05-05 | 2011-11-10 | Caridianbct, Inc. | Method of reseeding adherent cells grown in a hollow fiber bioreactor system |
WO2011143499A1 (en) | 2010-05-12 | 2011-11-17 | Tengion, Inc. | Bioactive renal cells |
EP2412798A1 (en) * | 2010-07-27 | 2012-02-01 | Gambro Lundia AB | Biomimetic membrane for cell expansion |
EP2625264B1 (en) | 2010-10-08 | 2022-12-07 | Terumo BCT, Inc. | Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions |
WO2012057701A1 (en) * | 2010-10-25 | 2012-05-03 | Agency For Science, Technology And Research | Tubular fiber membrane with nanoporous skin |
CN103298498B (en) | 2010-11-10 | 2017-12-08 | 因瑞金公司 | Ejection preparation for organ enhancing |
AU2012271341B2 (en) | 2011-06-15 | 2017-07-13 | The Charles Stark Draper Laboratory, Inc. | Systems, methods, and devices relating to a biomimetic cellularized nephron unit |
EP2797645B1 (en) | 2011-12-28 | 2017-10-18 | Xerem Medical Ltd. | System and method for blood filtering and/or treatment |
WO2015073913A1 (en) | 2013-11-16 | 2015-05-21 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
US11008547B2 (en) | 2014-03-25 | 2021-05-18 | Terumo Bct, Inc. | Passive replacement of media |
US20160090569A1 (en) | 2014-09-26 | 2016-03-31 | Terumo Bct, Inc. | Scheduled Feed |
WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
CN105457118B (en) * | 2015-12-17 | 2018-01-02 | 珠海健帆生物科技股份有限公司 | Apparatus for purifying blood and system |
CN105733944A (en) * | 2016-05-04 | 2016-07-06 | 浙江大学 | Construction method for six-pore plate hepatic cell hollow fiber reactor |
EP3464565A4 (en) | 2016-05-25 | 2020-01-01 | Terumo BCT, Inc. | Cell expansion |
US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
US11123372B2 (en) | 2016-07-29 | 2021-09-21 | Prokidney | Bioactive renal cells for the treatment of chronic kidney disease |
CN110035778B (en) * | 2016-09-06 | 2022-01-21 | 哈佛大学的校长及成员们 | Living device, method and use for replacing or specifying organ functions |
US11052230B2 (en) | 2016-11-08 | 2021-07-06 | W. L. Gore & Associates, Inc. | Implantable encapsulation devices |
US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
US11629332B2 (en) | 2017-03-31 | 2023-04-18 | Terumo Bct, Inc. | Cell expansion |
US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
WO2019198674A1 (en) * | 2018-04-13 | 2019-10-17 | 日機装株式会社 | Cell culture method, method for producing cell support complex, cultured cell and cell support complex |
WO2023210765A1 (en) * | 2022-04-28 | 2023-11-02 | 株式会社クラレ | Immunoisolation device |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3734851A (en) * | 1969-12-29 | 1973-05-22 | K Matsumura | Method and device for purifying blood |
CA1027304A (en) * | 1973-06-06 | 1978-03-07 | Theodore E. Spielberg | Artificial gland structure |
US4242460A (en) * | 1978-12-26 | 1980-12-30 | Chick William L | Cell culture device |
EP0058275A1 (en) * | 1981-02-17 | 1982-08-25 | SENKO MEDICAL INSTRUMENT Mfg Co., LTD | Hollow fiber artificial kidney |
US4354933A (en) * | 1981-02-23 | 1982-10-19 | Lester James P | Implantable artificial kidney |
JPS61115569A (en) * | 1984-11-09 | 1986-06-03 | テルモ株式会社 | Artificial kidney and its production |
US5035708A (en) * | 1985-06-06 | 1991-07-30 | Thomas Jefferson University | Endothelial cell procurement and deposition kit |
IL78950A (en) * | 1985-06-06 | 1991-12-15 | Univ Jefferson | Coating for prosthetic devices |
JP2739758B2 (en) * | 1987-02-24 | 1998-04-15 | ヴィレス,ジョセフ・エム | Liver assist device using transformed cell line |
WO1989001967A1 (en) * | 1987-09-03 | 1989-03-09 | Brown University Research Foundation | Blood purification with cultured renal cells |
JP2835629B2 (en) * | 1989-05-18 | 1998-12-14 | ザ リージェンツ オブ ザ ユニヴァーシティ オブ ミネソタ | Bioreactor equipment |
WO1991000119A1 (en) * | 1989-06-30 | 1991-01-10 | Baxter International Inc. | Implantable device |
US5192747A (en) * | 1989-10-03 | 1993-03-09 | Merrell Dow Pharmaceuticals Inc. | Anticoagulant peptides |
WO1992007615A1 (en) * | 1990-10-29 | 1992-05-14 | Regents Of The University Of Minnesota | A bioartificial liver |
US5429938A (en) * | 1992-03-02 | 1995-07-04 | University Of Michigan | Methods and compositions for isolation and growth of kidney tubule stem cells, in vitro kidney tubulogenesis and ex vivo construction of renal tubules |
-
1993
- 1993-10-08 US US08/133,436 patent/US5549674A/en not_active Expired - Lifetime
-
1994
- 1994-10-11 CA CA2710965A patent/CA2710965C/en not_active Expired - Fee Related
- 1994-10-11 AU AU79701/94A patent/AU692191B2/en not_active Ceased
- 1994-10-11 EP EP94930647A patent/EP0746343B1/en not_active Expired - Lifetime
- 1994-10-11 CA CA002173594A patent/CA2173594C/en not_active Expired - Fee Related
- 1994-10-11 AT AT94930647T patent/ATE257018T1/en active
- 1994-10-11 DE DE69433464T patent/DE69433464T2/en not_active Expired - Lifetime
- 1994-10-11 JP JP51191995A patent/JP3614853B2/en not_active Expired - Fee Related
- 1994-10-11 WO PCT/US1994/011384 patent/WO1995011048A2/en active IP Right Grant
-
1995
- 1995-06-07 US US08/487,327 patent/US5686289A/en not_active Expired - Lifetime
-
2004
- 2004-05-31 JP JP2004161578A patent/JP3795900B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ATE257018T1 (en) | 2004-01-15 |
JP3614853B2 (en) | 2005-01-26 |
JP2004267795A (en) | 2004-09-30 |
CA2710965A1 (en) | 1995-04-27 |
CA2173594C (en) | 2004-09-07 |
AU692191B2 (en) | 1998-06-04 |
WO1995011048A3 (en) | 1995-06-22 |
EP0746343B1 (en) | 2004-01-02 |
EP0746343A1 (en) | 1996-12-11 |
WO1995011048A2 (en) | 1995-04-27 |
DE69433464D1 (en) | 2004-02-05 |
AU7970194A (en) | 1995-05-08 |
EP0746343A4 (en) | 1997-12-03 |
JP3795900B2 (en) | 2006-07-12 |
US5549674A (en) | 1996-08-27 |
CA2710965C (en) | 2012-10-09 |
US5686289A (en) | 1997-11-11 |
DE69433464T2 (en) | 2004-11-11 |
JPH09503941A (en) | 1997-04-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2173594A1 (en) | Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo | |
NO20001509D0 (en) | Formation of hematopoietic cells from multipotent neutral stem cells | |
DE59309926D1 (en) | Module for breeding and using metabolic performance and / or for maintaining microorganisms | |
ATE162385T1 (en) | WATER WITHDRAWAL WITH HYDROGEL | |
AU2900792A (en) | Neomorphogenesis of urological structures in vivo from cell culture | |
AU641488B2 (en) | Human hematopoietic stem cell | |
CA2244659A1 (en) | Biological reactor for the cultivation of cells | |
DK0469070T3 (en) | Neomorphogenesis of cartilage in vivo from cell culture | |
EP0599651A3 (en) | Bioreactor for the perfusion culture of cells. | |
NZ290629A (en) | Controlling growth of cells within bioartificial organ | |
ES2070926T3 (en) | SUPPRESSION OF CELL PROLIFERATION THROUGH DECORIN. | |
AU2387795A (en) | Culture medium for maintaining viability of mammalian cells | |
CA2146734A1 (en) | Method for long term subculture of dermal papilla cells | |
AU3806695A (en) | Biomaterial containing epithelial cells and use thereof as a transplant | |
WO1999029279A3 (en) | Long-term survival and regeneration of central nervous system neurons | |
AU7937491A (en) | Permeable membrane excellent in biocompatibility | |
ZA917561B (en) | Media for culture of mammalian cells | |
DE3666458D1 (en) | Method and device for the _i(in vitro) culture of plant cells and organs, as well as for the micropropagation and regeneration of complete plants | |
DK0563256T3 (en) | Use of host cell phospholipids to inhibit bacterial colonization | |
AU8193391A (en) | Photobioreactors and closed ecological life support systems and artificial lungs containing the same | |
FR2691875B1 (en) | Modular growing media and their domestic use. | |
DE3854472T2 (en) | Maintenance of the viability of microorganisms for use in microbial inoculants. | |
FR2554124B1 (en) | CONTAINER FOR "IN VITRO" CULTURE OF FABRIC CELLS, PLANT ORGANS AND PLANTS | |
FR2735146B1 (en) | PROCESS FOR CULTURING MARINE INVERTEBRA CELLS AND CULTURES OBTAINED | |
PL285546A1 (en) | Biological culture medium for cell cultures and method of culturing human keratocytes as well as proteinous concentrate |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20141014 |