CA2175603A1 - Estrogen compositions and methods for neuroprotection - Google Patents

Estrogen compositions and methods for neuroprotection

Info

Publication number
CA2175603A1
CA2175603A1 CA002175603A CA2175603A CA2175603A1 CA 2175603 A1 CA2175603 A1 CA 2175603A1 CA 002175603 A CA002175603 A CA 002175603A CA 2175603 A CA2175603 A CA 2175603A CA 2175603 A1 CA2175603 A1 CA 2175603A1
Authority
CA
Canada
Prior art keywords
neuroprotection
methods
estrogen compositions
estrogen
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002175603A
Other languages
French (fr)
Other versions
CA2175603C (en
Inventor
James W. Simpkins
Meharvan Singh
Jean Bishop
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Florida Research Foundation Inc
Original Assignee
James W. Simpkins
Meharvan Singh
Jean Bishop
University Of Florida
University Of Florida Research Foundation, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by James W. Simpkins, Meharvan Singh, Jean Bishop, University Of Florida, University Of Florida Research Foundation, Inc. filed Critical James W. Simpkins
Publication of CA2175603A1 publication Critical patent/CA2175603A1/en
Application granted granted Critical
Publication of CA2175603C publication Critical patent/CA2175603C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis

Abstract

The use of an estrogen compound is described for protecting a population of nerve cells from death. The compound can be used in the treatment of a subject affected by a neurodegenerative disorder, in order to prevent the loss of neuronal activity.
CA002175603A 1993-11-05 1994-11-07 Estrogen compositions and methods for neuroprotection Expired - Fee Related CA2175603C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US14917593A 1993-11-05 1993-11-05
US08/149,175 1993-11-05
US08/318,042 1994-10-04
US08/318,042 US5554601A (en) 1993-11-05 1994-10-04 Methods for neuroprotection
PCT/US1994/012782 WO1995012402A1 (en) 1993-11-05 1994-11-07 Estrogen compositions and method for neuroprotection

Publications (2)

Publication Number Publication Date
CA2175603A1 true CA2175603A1 (en) 1995-05-11
CA2175603C CA2175603C (en) 2008-01-08

Family

ID=26846524

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002175603A Expired - Fee Related CA2175603C (en) 1993-11-05 1994-11-07 Estrogen compositions and methods for neuroprotection

Country Status (7)

Country Link
US (2) US5554601A (en)
EP (2) EP0799041A1 (en)
JP (2) JPH11514327A (en)
KR (1) KR960705573A (en)
AU (1) AU699361B2 (en)
CA (1) CA2175603C (en)
WO (1) WO1995012402A1 (en)

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Also Published As

Publication number Publication date
EP0799041A1 (en) 1997-10-08
JPH11514327A (en) 1999-12-07
AU699361B2 (en) 1998-12-03
WO1995012402A1 (en) 1995-05-11
AU1090195A (en) 1995-05-23
CA2175603C (en) 2008-01-08
JP2005290007A (en) 2005-10-20
EP1618882A3 (en) 2008-11-26
KR960705573A (en) 1996-11-08
US5843934A (en) 1998-12-01
EP1618882A2 (en) 2006-01-25
US5554601A (en) 1996-09-10

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