CA2177143A1 - Metal chelate containing compositions for use in chemiluminescent assays - Google Patents

Metal chelate containing compositions for use in chemiluminescent assays

Info

Publication number
CA2177143A1
CA2177143A1 CA002177143A CA2177143A CA2177143A1 CA 2177143 A1 CA2177143 A1 CA 2177143A1 CA 002177143 A CA002177143 A CA 002177143A CA 2177143 A CA2177143 A CA 2177143A CA 2177143 A1 CA2177143 A1 CA 2177143A1
Authority
CA
Canada
Prior art keywords
metal chelate
containing compositions
analyte
kits
chemiluminescent assays
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002177143A
Other languages
French (fr)
Other versions
CA2177143C (en
Inventor
Edwin F. Ullman
Sharat Singh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics Products GmbH
Original Assignee
Edwin F. Ullman
Sharat Singh
Behringwerke Ag
Syntex (U.S.A.) Inc.
Hoechst Aktiengesellschaft
Dade Behring Marburg Gmbh
Siemens Healthcare Diagnostics Products Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Edwin F. Ullman, Sharat Singh, Behringwerke Ag, Syntex (U.S.A.) Inc., Hoechst Aktiengesellschaft, Dade Behring Marburg Gmbh, Siemens Healthcare Diagnostics Products Gmbh filed Critical Edwin F. Ullman
Publication of CA2177143A1 publication Critical patent/CA2177143A1/en
Application granted granted Critical
Publication of CA2177143C publication Critical patent/CA2177143C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/06—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/5436—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand physically entrapped within the solid phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/586—Liposomes, microcapsules or cells
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/13—Tracers or tags

Abstract

Compositions are disclosed comprising (a) a metal chelate wherein the metal is selected from the group consisting of europium, terbium, dysprosium, samarium, osmium and ruthenium in at least a hexacoordinated state and (b) a compound having a double bond substituted with two aryl groups, an oxygen atom and an atom selected from the group consisting of oxygen, sulfur and nitrogen wherein one of the aryl groups is electron donating with respect to the other. Such composition is preferably incorporated in a latex particulate material. Methods and kits are also disclosed for determining an analyte in a medium suspected of containing the analyte. The methods and kits employs as one component a composition as described above.
CA002177143A 1993-11-22 1994-11-21 Metal chelate containing compositions for use in chemiluminescent assays Expired - Lifetime CA2177143C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/156,181 US5578498A (en) 1991-05-22 1993-11-22 Metal chelate containing compositions for use in chemiluminescent assays
US08/156181 1993-11-22
PCT/US1994/013193 WO1995014928A1 (en) 1993-11-22 1994-11-21 Metal chelate containing compositions for use in chemiluminescent assays

Publications (2)

Publication Number Publication Date
CA2177143A1 true CA2177143A1 (en) 1995-06-01
CA2177143C CA2177143C (en) 2007-09-18

Family

ID=22558459

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002177143A Expired - Lifetime CA2177143C (en) 1993-11-22 1994-11-21 Metal chelate containing compositions for use in chemiluminescent assays

Country Status (7)

Country Link
US (9) US5578498A (en)
EP (2) EP0730738B1 (en)
JP (1) JP3426241B2 (en)
AT (1) ATE239917T1 (en)
CA (1) CA2177143C (en)
DE (1) DE69432640T2 (en)
WO (1) WO1995014928A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102348980A (en) * 2009-03-12 2012-02-08 西门子医疗保健诊断公司 Immunoassays employing non-particulate chemiluminescent reagent

Families Citing this family (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6395506B1 (en) * 1991-04-18 2002-05-28 Becton, Dickinson And Company Device for monitoring cells
US5578498A (en) * 1991-05-22 1996-11-26 Behringwerke Ag Metal chelate containing compositions for use in chemiluminescent assays
US6251581B1 (en) * 1991-05-22 2001-06-26 Dade Behring Marburg Gmbh Assay method utilizing induced luminescence
US6002000A (en) * 1992-07-20 1999-12-14 Dade Behring Marburg Gmbh Chemiluminescent compounds and methods of use
EP0651752A1 (en) * 1992-07-20 1995-05-10 Behringwerke Ag Novel chemiluminescent compounds and methods of use
WO1995008642A1 (en) * 1993-09-23 1995-03-30 Zeneca Limited Nucleic acid detection with energy transfer
JP2000505439A (en) * 1996-02-19 2000-05-09 シャファー、モシェ Photosensitive composition
EP0852012B1 (en) * 1996-05-01 2006-07-26 Dade Behring Marburg GmbH Chemiluminescent compositions and their use in the detection of hydrogen peroxide
US6028025A (en) * 1996-10-21 2000-02-22 Massachusetts Institute Of Technology Metalloporphyrin oxidation catalyst covalently coupled to an inorganic surface and method making same
US6753191B2 (en) 1996-11-06 2004-06-22 University Of Pittsburgh Polymerized crystalline colloidal array chemical sensing materials for use in high ionic strength solutions
US5898004A (en) * 1996-11-06 1999-04-27 University Of Pittsburgh Of The Commonwealth System Of Higher Education Polymerized crystalline colloidal array sensors
US5854078A (en) 1996-11-06 1998-12-29 University Of Pittsburgh Polymerized crystalline colloidal array sensor methods
US5772926A (en) * 1997-05-13 1998-06-30 Lumigen, Inc. Chemiluminescent reactions using dihydroxyaromatic compounds and heterocyclic enol phosphates
ATE239912T1 (en) * 1997-08-01 2003-05-15 Presens Prec Sensing Gmbh METHOD AND DEVICE FOR REFERENCEING FLUORESCENCE INTENSITY SIGNALS
US6322980B1 (en) * 1999-04-30 2001-11-27 Aclara Biosciences, Inc. Single nucleotide detection using degradation of a fluorescent sequence
US20040248150A1 (en) * 1999-04-02 2004-12-09 Sharat Singh Methods employing oligonucleotide-binding e-tag probes
US6514700B1 (en) * 1999-04-30 2003-02-04 Aclara Biosciences, Inc. Nucleic acid detection using degradation of a tagged sequence
US6627400B1 (en) 1999-04-30 2003-09-30 Aclara Biosciences, Inc. Multiplexed measurement of membrane protein populations
US7037654B2 (en) 1999-04-30 2006-05-02 Aclara Biosciences, Inc. Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents
US7001725B2 (en) 1999-04-30 2006-02-21 Aclara Biosciences, Inc. Kits employing generalized target-binding e-tag probes
US6673550B2 (en) 1999-04-30 2004-01-06 Aclara Biosciences, Inc. Electrophoretic tag reagents comprising fluorescent compounds
US20030235832A1 (en) * 2000-06-21 2003-12-25 Ahmed Chenna Multiplexed analysis by chromatographic separation of molecular tags
DE19933104A1 (en) * 1999-07-15 2001-01-18 Ingo Klimant Phosphorescent micro- and nanoparticles as reference standards and phosphorescence markers
US6329205B1 (en) 1999-08-31 2001-12-11 Molecular Probes, Inc. Detection method using luminescent europium-based protein stains
WO2001032665A2 (en) * 1999-11-01 2001-05-10 Fluorrx, Inc. New ruthenium metal ligand complexes
US6703248B1 (en) * 1999-12-15 2004-03-09 Dade Behring Marburg Gmbh Particles for diagnostic and therapeutic use
US7179660B1 (en) 2000-03-06 2007-02-20 Dade Behring Marburg Gmbh Carriers coated with polysaccharides, their preparation and use
US20030207300A1 (en) * 2000-04-28 2003-11-06 Matray Tracy J. Multiplex analytical platform using molecular tags
US7537938B2 (en) * 2000-04-28 2009-05-26 Monogram Biosciences, Inc. Biomarker detection in circulating cells
US7160735B2 (en) * 2000-04-28 2007-01-09 Monogram Biosciences, Inc. Tagged microparticle compositions and methods
US7771929B2 (en) * 2000-04-28 2010-08-10 Monogram Biosciences, Inc. Tag library compounds, compositions, kits and methods of use
US7635571B2 (en) * 2000-12-07 2009-12-22 Siemens Healthcare Diagnostics Products Gmbh Amplified signal in binding assays
SG92833A1 (en) * 2001-03-27 2002-11-19 Sumitomo Chemical Co Polymeric light emitting substance and polymer light emitting device using the same
US7354733B2 (en) * 2001-03-29 2008-04-08 Cellect Technologies Corp. Method for sorting and separating living cells
CN1559006A (en) * 2001-05-21 2004-12-29 埃克来拉生物科学公司 Methods and compositions for analyzing proteins
AU2002305658A1 (en) 2001-05-21 2002-12-03 Aclara Biosciences, Inc. Analyzing phosphorylated proteins
WO2002097112A2 (en) * 2001-05-26 2002-12-05 Aclara Biosciences, Inc. Catalytic amplification of multiplexed assay signals
EP1419211A1 (en) * 2001-08-23 2004-05-19 Honeywell International Inc. Europium-ammonium tetra chelates
US7045311B2 (en) * 2001-10-25 2006-05-16 Monogram Biosciences, Inc. Whole cell assay systems for cell surface proteases
CN1166422C (en) * 2001-11-05 2004-09-15 北京源德生物医学工程股份有限公司 Holder for external high-energy focusing ultrasonic treating apparatus
US20050053939A1 (en) * 2001-11-09 2005-03-10 Ahmed Chenna Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents
US6949347B2 (en) * 2002-03-05 2005-09-27 Aclara Biosciences, Inc. Multiplex analysis using membrane-bound sensitizers
US7402397B2 (en) * 2002-05-21 2008-07-22 Monogram Biosciences, Inc. Detecting and profiling molecular complexes
US20040229294A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB surface receptor complexes as biomarkers
US20040229299A1 (en) * 2002-05-21 2004-11-18 Badal M. Youssouf Intracellular complexes as biomarkers
US20040229380A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB heterodimers as biomarkers
US20040229293A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui Surface receptor complexes as biomarkers
US20040175765A1 (en) * 2002-07-05 2004-09-09 Sharat Singh Cell-screening assay and composition
ES2332310T3 (en) 2002-07-25 2010-02-02 Aclara Biosciences, Inc. RECEIVER OLIGOMERIZATION DETECTION.
US6783699B2 (en) 2002-10-17 2004-08-31 Medgene, Inc. Europium-containing fluorescent nanoparticles and methods of manufacture thereof
WO2004040305A1 (en) * 2002-10-31 2004-05-13 Reverse Proteomics Research Institute Co., Ltd. Method of immobilizing compound on solid phase support
US20040091850A1 (en) * 2002-11-08 2004-05-13 Travis Boone Single cell analysis of membrane molecules
US7179542B2 (en) 2003-05-20 2007-02-20 Canon Kabushiki Kaisha Thiazole- and imidazole-fused phenanthroline molecules in organic light-emitting devices
EP1640429A4 (en) * 2003-05-22 2010-03-10 Mitsubishi Chem Corp Light-emitting device and phosphor
US7402398B2 (en) * 2003-07-17 2008-07-22 Monogram Biosciences, Inc. Measuring receptor homodimerization
NZ545873A (en) * 2003-08-11 2009-05-31 Monogram Biosciences Inc Detecting and profiling molecular complexes
WO2005045058A2 (en) * 2003-10-27 2005-05-19 Monogram Biosciences, Inc. Detecting human anti-therapeutic antibodies
CA2547351A1 (en) 2003-12-01 2005-07-07 Dade Behring Marburg Gmbh Homogeneous detection method
US7722842B2 (en) * 2003-12-31 2010-05-25 The Ohio State University Carbon dioxide sequestration using alkaline earth metal-bearing minerals
AU2005254970B2 (en) * 2004-06-09 2011-06-09 Perkinelmer Health Sciences, Inc. Methods for target molecule detection using siderophores and related compositions
US7807468B2 (en) * 2004-07-21 2010-10-05 Bates Lynn S Methods of marking and testing pharmaceutical products
US7964407B2 (en) * 2004-07-21 2011-06-21 Bates Lynn S Methods of marking products using natural materials having genetically controlled micromorphological structures as markers
US20060040258A1 (en) * 2004-08-23 2006-02-23 Huiyan Guo Water-soluble conjugates and methods of preparation
KR20070099519A (en) * 2004-09-17 2007-10-09 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 Trivalent metal mediated homogeneous luminescent proximity assay
US7939267B2 (en) * 2004-11-04 2011-05-10 Laboratory Corporation Of America Holdings Detection of activation of endothelial cells as surrogate marker for angiogenesis
US20060166376A1 (en) * 2005-01-21 2006-07-27 Craig Alan R Compositions for use as a signal generation component and methods of using same
CN100429197C (en) * 2005-02-04 2008-10-29 博阳生物科技（上海）有限公司 Compound of di-butanedione, complexes of europium, combination of containing the complexes and application
US20060205090A1 (en) * 2005-03-14 2006-09-14 Newton Michael W Water-soluble conjugates for electrochemical detection
CN100445744C (en) * 2005-04-25 2008-12-24 博阳生物科技（上海）有限公司 Microsphere combination or subassembly in use for immunity analysis, and immunity analysis method
WO2007008472A2 (en) * 2005-07-08 2007-01-18 Colorado Seminary, Which Owns And Operates The University Of Denver Photoinduced signal amplification through externally sensitized photofragmentation in masked photosensitizers
WO2007070761A2 (en) * 2005-12-12 2007-06-21 Colorado Seminary, Which Owns And Operates The University Of Denver Method for encoding and screening combinatorial libraries
WO2008098100A2 (en) * 2007-02-07 2008-08-14 Perscitus Biosciences, Llc Detection of molecule proximity
WO2009026313A1 (en) * 2007-08-20 2009-02-26 Colorado Seminary, Which Owns And Operates The University Of Denver Photoinduced signal amplification through externally sensitized photofragmentation in masked photosensitizers and photoamplified fluorescence turn-off system
CA2706763C (en) * 2007-11-27 2013-07-30 Laboratory Corporation Of America Holdings Enhanced method for detecting and/or quantifying an analyte in a sample
US10416162B2 (en) * 2007-12-20 2019-09-17 Monogram Biosciences, Inc. Her2 diagnostic methods
CN101251540B (en) * 2008-03-26 2012-12-05 博阳生物科技（上海）有限公司 Hepatitis B virus e antigen testing corpuscle, preparation and application thereof
EP3666858A3 (en) 2008-09-26 2020-08-19 The Ohio State University A method of preparing ceramic composite particles
WO2010065568A2 (en) 2008-12-01 2010-06-10 Laboratory Corporation Of America Holdings METHODS AND ASSAYS FOR MEASURING p95 AND/OR p95 IN A SAMPLE AND ANTIBODIES SPECIFIC FOR p95
ES2535723T3 (en) 2009-01-15 2015-05-14 Laboratory Corporation Of America Holdings Methods for determining the patient's response by measuring Her-3
US8486719B2 (en) 2009-02-20 2013-07-16 Perkinelmer Biosignal, Inc. Multiplex assay methods and compositions
JP5311662B2 (en) * 2009-08-24 2013-10-09 キッコーマン株式会社 Luminescence enhancement method for peroxidase chemiluminescence reaction and luminescence enhancer for peroxidase chemiluminescence reaction
AU2010292313B2 (en) 2009-09-08 2015-08-20 The Ohio State University Research Foundation Integration of reforming/water splitting and electrochemical systems for power generation with integrated carbon capture
EP2483371B1 (en) 2009-09-08 2017-11-08 The Ohio State University Research Foundation Synthetic fuels and chemicals production with in-situ co2 capture
US8153442B2 (en) * 2009-10-21 2012-04-10 Siemens Healthcare Diagnostics Inc. Stabilization of signal generation in particles used in assays
US20110306148A1 (en) 2010-06-14 2011-12-15 Siemens Healthcare Diagnostics Inc. Composition for use as an assay reagent
US10088490B2 (en) 2010-08-20 2018-10-02 Siemens Healthcare Diagnostics Inc. Assay for analytes using multiple receptors
US10010847B2 (en) 2010-11-08 2018-07-03 Ohio State Innovation Foundation Circulating fluidized bed with moving bed downcomers and gas sealing between reactors
DE102011007546A1 (en) 2011-04-15 2012-10-18 Humboldt-Universität Zu Berlin Measuring device for measuring singlet oxygen luminescence
CA2835419C (en) 2011-05-11 2020-06-02 Ohio State Innovation Foundation Systems for converting fuel
AU2012253332B2 (en) 2011-05-11 2017-05-11 Ohio State Innovation Foundation Oxygen carrying materials
CA2835284C (en) 2011-05-19 2020-08-25 Laboratory Corporation Of America Holdings Methods for determining the likelihood of survival and for predicting likelihood of metastasis in cancer patients
EP2742352B1 (en) 2011-08-12 2018-02-28 Siemens Healthcare Diagnostics Inc. Detection of sex steroids
US9244083B2 (en) 2012-11-30 2016-01-26 Siemens Healthcare Diagnostics Inc. Compositions and methods for detecting vitamin D
EP2953892B1 (en) 2013-02-05 2023-04-05 Ohio State Innovation Foundation Methods for fuel conversion
WO2014152914A1 (en) 2013-03-14 2014-09-25 Ohio State Innovation Foundation Systems and methods for converting carbonaceous fuels
CA2908515A1 (en) 2013-04-05 2014-10-09 Laboratory Corporation Of America Holdings Systems and methods for facilitating diagnosis, prognosis and treatment of cancer based on detection of her3 activation
US20140308751A1 (en) 2013-04-12 2014-10-16 Siemens Healthcare Diagnostics Inc. Assays for Analyte Homologs
US10124072B2 (en) 2013-09-18 2018-11-13 Caliper Life Sciences, Inc. In-vivo reactive species imaging
WO2015131117A1 (en) 2014-02-27 2015-09-03 Ohio State Innovation Foundation Systems and methods for partial or complete oxidation of fuels
KR20170014013A (en) 2014-06-27 2017-02-07 지멘스 헬쓰케어 다이아그노스틱스 인크. Binding partners specific for vitamin d epimers
KR20170016009A (en) 2014-06-27 2017-02-10 지멘스 헬쓰케어 다이아그노스틱스 인크. Binding partners specific for vitamin d epimers in vitamin d assays
EP3403095B1 (en) 2016-03-15 2019-08-07 Laboratory Corporation of America Holdings Methods of assessing protein interactions between cells
CN109195696B (en) 2016-04-12 2022-04-26 俄亥俄州立创新基金会 Chemical recycle production of synthesis gas from carbonaceous fuels
AU2017292172A1 (en) 2016-07-06 2019-01-03 Prothena Biosciences Limited Assay for detecting total and S129 phosphorylated alpha-synuclein
WO2019027972A1 (en) 2017-07-31 2019-02-07 Ohio State Innovation Foundation Reactor system with unequal reactor assembly operating pressures
WO2019118592A1 (en) * 2017-12-12 2019-06-20 Massachusetts Institute Of Technology Cell-permeable imaging sensors and uses thereof
US10549236B2 (en) 2018-01-29 2020-02-04 Ohio State Innovation Foundation Systems, methods and materials for NOx decomposition with metal oxide materials
CN110514651A (en) 2018-05-21 2019-11-29 博阳生物科技（上海）有限公司 A kind of chemiluminscence immunoassay method and the system using this method, kit
JP2021525376A (en) 2018-05-21 2021-09-24 ビヨンド ダイアグノステイックス （シャンハイ） カンパニー リミテッド Chemiluminescent immunoassay measurement method and systems and reagent kits using the method
KR102281252B1 (en) * 2018-05-21 2021-07-23 (주)인벤티지랩 Microparticles containing dutasteride and method for manufacturing same
JP7122454B2 (en) 2018-07-30 2022-08-19 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド Kits, microfluidic devices, and methods for performing biotin assays
US11413574B2 (en) 2018-08-09 2022-08-16 Ohio State Innovation Foundation Systems, methods and materials for hydrogen sulfide conversion
CA3129146A1 (en) 2019-04-09 2020-10-15 Liang-Shih Fan Alkene generation using metal sulfide particles
CN112500434B (en) * 2020-11-20 2021-10-22 复旦大学 Iridium complex-based optical trigger molecule and application
CN115947714A (en) * 2022-11-01 2023-04-11 上海泰辉生物科技有限公司 Method for synthesizing photochemical buffering agent

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3340716A (en) * 1964-11-10 1967-09-12 Reynolds Metals Co Method of producing wrought structure
US3720622A (en) * 1970-01-02 1973-03-13 American Cyanamid Co Generation of light from the decomposition of dioxetaneones in the presence of a fluorescer
US3850578A (en) 1973-03-12 1974-11-26 H Mcconnell Process for assaying for biologically active molecules
US4043792A (en) * 1974-04-09 1977-08-23 Uniroyal, Inc. Plant growth regulation using certain substituted 2,3-dihydro-1,4-oxathiins
US3947264A (en) * 1974-04-09 1976-03-30 Uniroyal, Inc. Substituted 2,3-dihydro-,4-oxathiin plant growth stunting agents
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4199559A (en) 1974-08-12 1980-04-22 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4383031A (en) 1975-04-28 1983-05-10 Miles Laboratories, Inc. Homogeneous chemiluminescent specific binding assay
US4174384A (en) 1975-06-30 1979-11-13 Syva Company Fluorescence quenching with immunological pairs in immunoassays
CA1121647A (en) 1977-11-09 1982-04-13 Norman L. Betz Feed intake limiting acidulated fat for animals
US4529561A (en) 1978-03-24 1985-07-16 The Regents Of The University Of California Method for producing liposomes in selected size range
US4277437A (en) 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4220450A (en) 1978-04-05 1980-09-02 Syva Company Chemically induced fluorescence immunoassay
US4233402A (en) 1978-04-05 1980-11-11 Syva Company Reagents and method employing channeling
US4380580A (en) 1978-04-10 1983-04-19 Miles Laboratories, Inc. Heterogenous chemiluminescent specific binding assay
US4193983A (en) 1978-05-16 1980-03-18 Syva Company Labeled liposome particle compositions and immunoassays therewith
AU517292B2 (en) 1978-06-20 1981-07-23 Syva Co. Fluorescence quenching system
US4226993A (en) 1978-07-24 1980-10-07 Miles Laboratories, Inc. Amino-functionalized phthalhydrazides
US4318707A (en) 1978-11-24 1982-03-09 Syva Company Macromolecular fluorescent quencher particle in specific receptor assays
US4576912A (en) 1978-11-30 1986-03-18 Technicon Instruments Corporation Fluoroimmunoassaying
US4261968A (en) 1979-05-10 1981-04-14 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4299916A (en) 1979-12-26 1981-11-10 Syva Company Preferential signal production on a surface in immunoassays
CA1130297A (en) * 1980-05-02 1982-08-24 Michael A. Puttock Method of making 2,3-dihydro-5,6-diphenyl- 1,4-oxathiin
US4483921A (en) 1981-01-12 1984-11-20 Collaborative Research, Inc. Immunoassay with antigen or antibody labeled liposomes sequestering enzyme
US4650770A (en) 1981-04-27 1987-03-17 Syntex (U.S.A.) Inc. Energy absorbing particle quenching in light emitting competitive protein binding assays
CA1180647A (en) * 1981-07-17 1985-01-08 Cavit Akin Light-emitting polynucleotide hybridization diagnostic method
CA1190838A (en) * 1981-07-17 1985-07-23 Cavit Akin Homogeneous nucleic acid hybridization diagnostics by non-radiative energy transfer
US4522803A (en) 1983-02-04 1985-06-11 The Liposome Company, Inc. Stable plurilamellar vesicles, their preparation and use
US4654300A (en) 1982-04-02 1987-03-31 Syntex (U.S.A.) Inc. Fluorescent microbead quenching assay
US4483929A (en) 1982-05-03 1984-11-20 Liposome Technology Incorporated Liposomes with glycolipid-linked antibodies
US4485054A (en) 1982-10-04 1984-11-27 Lipoderm Pharmaceuticals Limited Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
US4568649A (en) 1983-02-22 1986-02-04 Immunex Corporation Immediate ligand detection assay
US4588578A (en) 1983-08-08 1986-05-13 The Liposome Company, Inc. Lipid vesicles prepared in a monophase
US4652533A (en) 1983-04-28 1987-03-24 Pandex Laboratories, Inc. Method of solid phase immunoassay incorporating a luminescent label
JPS6036962A (en) 1983-08-09 1985-02-26 Toray Ind Inc Fine particle for biological inspection
EP0144914A3 (en) 1983-12-12 1986-08-13 Miles Inc. Hybridization assay employing labeled pairs of hybrid binding reagents
CA1273552A (en) 1985-12-23 1990-09-04 Michael J. Heller Fluorescent stokes shift probes for polynucleotide hybridization assays
ATE88761T1 (en) 1986-01-10 1993-05-15 Amoco Corp COMPETITIVE HOMOGENEOUS TEST.
WO1987005334A1 (en) 1986-03-04 1987-09-11 Angenics, Inc. Nucleic acid detection using particle agglutination
US5254477A (en) 1986-06-25 1993-10-19 Trustees Of Tufts College Flourescence intramolecular energy transfer conjugate compositions and detection methods
US5143853A (en) 1986-06-25 1992-09-01 Trustees Of Tufts College Absorbance modulated fluorescence detection methods and sensors
US5004565A (en) 1986-07-17 1991-04-02 The Board Of Governors Of Wayne State University Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes
US5616729A (en) 1986-07-17 1997-04-01 Board Of Governors Of Wayne State University Enhanced chemiluminescence from 1,2-dioxetanes through energy transfer to tethered fluorescers
US4857652A (en) * 1986-07-17 1989-08-15 Board Of Governors Of Wayne State University Chemiluminescent 1,2-dioxetane compounds
US4959182A (en) 1986-07-17 1990-09-25 Board Of Governors Of Wayne State University Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes
BR8707399A (en) 1986-07-24 1988-09-13 Quest Systems Inc METHOD OF DETECTING A SUBSTANCE BY USING ENZYMATICALLY INDUCED DIOXETANE DECOMPOSITION
US4978614A (en) 1988-10-26 1990-12-18 Tropix, Inc. Method of detecting a substance using enzymatically-induced decomposition of dioxetanes
US4891324A (en) 1987-01-07 1990-01-02 Syntex (U.S.A.) Inc. Particle with luminescer for assays
US4806485A (en) * 1987-02-27 1989-02-21 Cooperative Institute For Research In Environmental Sciences Univers. Of Colorado Method of improving the detection limits of UV-VIS absorbing compounds in HPLC by the use of a singlet oxygen trap
US5070158A (en) 1987-03-12 1991-12-03 Hewlett-Packard Company Covalently labeled siloxane polymers
US5017473A (en) 1987-05-26 1991-05-21 Becton, Dickinson And Company Homogeneous chemiluminescence immunoassay using a light absorbing material
US4822878A (en) 1987-06-30 1989-04-18 Viomedics, Inc. Cyclic anhydride derivatives of chromophors
SE8703682L (en) * 1987-09-24 1989-03-25 Wallac Oy HOMOGENIC DETERMINATION METHOD USING AFFINITY REACTIONS
US4943525A (en) 1987-11-02 1990-07-24 Bioventures, Inc. Simultaneous immunoassay for the determination of antigens and antibodies
US4910303A (en) * 1988-05-26 1990-03-20 Texaco Chemical Company Process for preparing oxazine derivatives
AU636110B2 (en) 1988-06-08 1993-04-22 Nichols Institute Diagnostics Assays utilizing sensitizer-induced production of detectable signal
WO1990002205A1 (en) 1988-08-25 1990-03-08 Angenics, Inc. Detection of nucleic acid sequences using particle agglutination
US5061445A (en) 1988-11-03 1991-10-29 Igen, Inc. Apparatus for conducting measurements of electrochemiluminescent phenomena
US5019496A (en) 1989-02-17 1991-05-28 Gerald Oster Photopolymerization diagnostic test composition and method for immunoassay and nucleic acid assay
CA2035029C (en) 1989-09-06 2001-12-18 Brooks Edwards Synthesis of stable water-soluble chemiluminescent 1,2-dioxetanes and intermediates therefor
JP3184894B2 (en) 1989-10-05 2001-07-09 エックスオックスエミス， インコーポレイテッド Haloperoxidase acid optimal chemiluminescence analysis system
DE69125992T2 (en) 1990-09-14 1997-08-21 Tosoh Corp Method and kit for immunoassay
FI88654C (en) * 1991-03-15 1993-06-10 Datacity Center Oy Fluorescenshoejningsmetod
US5340716A (en) 1991-06-20 1994-08-23 Snytex (U.S.A.) Inc. Assay method utilizing photoactivated chemiluminescent label
DE69233146T2 (en) * 1991-05-22 2004-04-29 Dade Behring Marburg Gmbh Particles containing a composition comprising a chemiluminescent compound
US6251581B1 (en) 1991-05-22 2001-06-26 Dade Behring Marburg Gmbh Assay method utilizing induced luminescence
US5578498A (en) * 1991-05-22 1996-11-26 Behringwerke Ag Metal chelate containing compositions for use in chemiluminescent assays
US5257970A (en) 1992-04-09 1993-11-02 Health Research, Inc. In situ photodynamic therapy
CA2141451C (en) 1992-07-31 2003-10-07 John S. Pease Photoactivatable chemiluminescent matrices
FR2707658B1 (en) 1993-07-12 1995-11-24 Prolabo Sa Fluorescent latex comprising at least two fluorochromes, process for obtaining and applying said latex as a marker, in particular in biology.
CA2170873A1 (en) 1993-09-03 1995-03-09 Dariush Davalian Fluorescent oxygen channeling immunoassays

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102348980A (en) * 2009-03-12 2012-02-08 西门子医疗保健诊断公司 Immunoassays employing non-particulate chemiluminescent reagent
US9347947B2 (en) 2009-03-12 2016-05-24 Siemens Healthcare Diagnostics Inc. Immunoassays employing non-particulate chemiluminescent reagent
US9720004B2 (en) 2009-03-12 2017-08-01 Siemens Healthcare Diagnostics Inc. Immunoassays employing non-particulate chemiluminescent reagent

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US5578498A (en) 1996-11-26

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