CA2189131A1 - Use of pteridine derivatives as no-synthase inhibitors - Google Patents
Use of pteridine derivatives as no-synthase inhibitorsInfo
- Publication number
- CA2189131A1 CA2189131A1 CA002189131A CA2189131A CA2189131A1 CA 2189131 A1 CA2189131 A1 CA 2189131A1 CA 002189131 A CA002189131 A CA 002189131A CA 2189131 A CA2189131 A CA 2189131A CA 2189131 A1 CA2189131 A1 CA 2189131A1
- Authority
- CA
- Canada
- Prior art keywords
- synthase inhibitors
- pteridine derivatives
- nitric oxide
- formula
- pteridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/99—Enzyme inactivation by chemical treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
Abstract
The present invention relates to the use of pteridine derivatives of the formula I
(see formula I) in which X is O, NH or N-(C1-C5)-alkanoyl, R3 is the radical -OR4, -NR5R6 or -S(O)m R7, and R, R1, R2, R4, R5, R6, R7 and m have the meanings given in claim 1, which are nitric oxide synthase inhibitors, for the treatment of diseases which are caused by an increased nitric oxide level.
(see formula I) in which X is O, NH or N-(C1-C5)-alkanoyl, R3 is the radical -OR4, -NR5R6 or -S(O)m R7, and R, R1, R2, R4, R5, R6, R7 and m have the meanings given in claim 1, which are nitric oxide synthase inhibitors, for the treatment of diseases which are caused by an increased nitric oxide level.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEP4418096.9 | 1994-05-24 | ||
DE4418096A DE4418096A1 (en) | 1994-05-24 | 1994-05-24 | Use of pteridine derivatives as inhibitors of NO synthase |
PCT/EP1995/001731 WO1995031987A1 (en) | 1994-05-24 | 1995-05-06 | Use of pteridine derivatives as no-synthase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2189131A1 true CA2189131A1 (en) | 1995-11-30 |
CA2189131C CA2189131C (en) | 2007-03-06 |
Family
ID=6518841
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002189131A Expired - Lifetime CA2189131C (en) | 1994-05-24 | 1995-05-06 | Use of pteridine derivatives as no-synthase inhibitors |
Country Status (9)
Country | Link |
---|---|
US (1) | US5902810A (en) |
EP (1) | EP0760664B1 (en) |
JP (1) | JP4138870B2 (en) |
AT (1) | ATE223220T1 (en) |
CA (1) | CA2189131C (en) |
DE (2) | DE4418096A1 (en) |
ES (1) | ES2180633T3 (en) |
PT (1) | PT760664E (en) |
WO (1) | WO1995031987A1 (en) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0897912A1 (en) * | 1993-10-21 | 1999-02-24 | G.D. Searle & Co. | Amidino derivatives useful as nitric oxide synthase inhibitors |
AU712315B2 (en) * | 1995-04-20 | 1999-11-04 | G.D. Searle & Co. | Cyclic amidino agents useful as nitric oxide synthase inhibitors |
US5945408A (en) * | 1996-03-06 | 1999-08-31 | G.D. Searle & Co. | Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors |
US6162806A (en) * | 1996-07-31 | 2000-12-19 | Artemis, Inc. | Active oxygen scavengers containing pterin derivatives |
US5922713A (en) * | 1997-06-26 | 1999-07-13 | Werner; Ernst | Inhibition of nitric oxide synthase |
US5981556A (en) * | 1997-07-22 | 1999-11-09 | G.D. Searle & Co. | 1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors |
DE59703603D1 (en) * | 1997-10-06 | 2001-06-28 | Ernst Werner | Pteridine derivatives as NO synthase inhibitors |
CA2319495A1 (en) * | 1998-06-08 | 1999-12-16 | Advanced Medicine, Inc. | Multibinding inhibitors of microsomal triglyceride transferase protein |
US6489323B1 (en) | 1998-06-10 | 2002-12-03 | G.D. Searle & Co. | Heterobicyclic and tricyclic nitric oxide synthase inhibitors |
US7276506B2 (en) | 1998-12-28 | 2007-10-02 | 4 Aza Bioscience Nv | Immunosuppressive effects of pteridine derivatives |
AU770551B2 (en) * | 1998-12-28 | 2004-02-26 | 4-Aza Bioscience Nv | Immunosuppressive effects of pteridine derivatives |
DE19944767A1 (en) * | 1999-09-17 | 2001-03-29 | Vasopharm Biotech Gmbh & Co Kg | N-substituted 4-aminopteridines, process for their preparation and their use as medicines |
US6344473B1 (en) | 2000-08-07 | 2002-02-05 | G.D. Searle & Co. | Imidazoles useful as nitric oxide synthase inhibitors |
WO2002076954A1 (en) * | 2001-03-23 | 2002-10-03 | Smithkline Beecham Corporation | Compounds useful as kinase inhibitors for the treatment of hyperproliferative diseases |
BR0315008A (en) * | 2002-10-04 | 2005-08-09 | Prana Biotechnology Ltd | Neurologically Active Compounds |
WO2005037286A1 (en) * | 2003-03-25 | 2005-04-28 | Vasopharm Biotech Gmbh | Use of pteridine derivatives for the treatment of increased intracranial pressure and secondary ischemia |
GB2405793A (en) * | 2003-09-12 | 2005-03-16 | 4 Aza Bioscience Nv | Pteridine derivatives for treating TNF-alpha related disorders |
PL3138566T3 (en) * | 2003-11-17 | 2022-03-07 | Biomarin Pharmaceutical Inc. | Treatment of phenylketonuria with bh4 |
AU2005306686B2 (en) | 2004-11-17 | 2011-06-02 | Biomarin Pharmaceutical Inc. | Stable tablet formulation of tetrahydrobiopterin |
BRPI0710737A2 (en) * | 2006-04-14 | 2011-05-10 | Prana Biotechnology Ltd | use of compounds pb-10 33 useful for the treatment of age-related macular degeneration (amd) as well as said compounds |
US10144736B2 (en) | 2006-07-20 | 2018-12-04 | Gilead Sciences, Inc. | Substituted pteridines useful for the treatment and prevention of viral infections |
ES2773931T3 (en) | 2008-06-05 | 2020-07-15 | Bausch Health Ireland Ltd | Topical pharmaceutical formulations containing a low concentration of benzoyl peroxide suspended in water and a water-miscible organic solvent |
US9216178B2 (en) | 2011-11-02 | 2015-12-22 | Biomarin Pharmaceutical Inc. | Dry blend formulation of tetrahydrobiopterin |
SI3321265T1 (en) | 2015-03-04 | 2020-07-31 | Gilead Sciences, Inc. | 4,6-diamino-pyrido(3,2-d)pyrimidine compounds and their utilisation as modulators of toll-like receptors |
WO2018045150A1 (en) | 2016-09-02 | 2018-03-08 | Gilead Sciences, Inc. | 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators |
PT3507276T (en) | 2016-09-02 | 2022-01-11 | Gilead Sciences Inc | Toll like receptor modulator compounds |
TW202212339A (en) | 2019-04-17 | 2022-04-01 | 美商基利科學股份有限公司 | Solid forms of a toll-like receptor modulator |
TW202210480A (en) | 2019-04-17 | 2022-03-16 | 美商基利科學股份有限公司 | Solid forms of a toll-like receptor modulator |
TW202115056A (en) | 2019-06-28 | 2021-04-16 | 美商基利科學股份有限公司 | Processes for preparing toll-like receptor modulator compounds |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4079056A (en) * | 1975-03-31 | 1978-03-14 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Method of making pteridine compounds |
DK426083A (en) * | 1982-09-20 | 1984-03-21 | Wellcome Found | PTERINES, PROCEDURES FOR THEIR PREPARATION AND THEIR USE |
DK160827C (en) * | 1984-02-03 | 1991-10-14 | Res Corp Technologies Inc | PTERIDIN DERIVATIVES, PROCEDURES FOR PREPARING THEM AND PHARMACEUTICAL PREPARATION |
IT1204612B (en) * | 1987-05-14 | 1989-03-10 | Bioresearch Spa | PTERIDINS SUITABLE FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS FOR ANTI-MAGNESIC ACTIVITIES |
JP2534423B2 (en) * | 1991-12-26 | 1996-09-18 | コーネル・リサーチ・ファンデーション・インコーポレイテッド | Inhibitors that prevent vascular disorders resulting from overproduction of nitric oxide |
JPH0656669A (en) * | 1992-06-11 | 1994-03-01 | Asahi Breweries Ltd | Pterine derivative preparation having active oxygen-scavenging action |
AU5704594A (en) * | 1992-12-18 | 1994-07-19 | Wellcome Foundation Limited, The | Pyrimidine, pyridine, pteridinone and indazole derivatives as enzyme inhibitors |
JPH0834782A (en) * | 1994-05-20 | 1996-02-06 | Nissan Chem Ind Ltd | Imino-type sulfonylurea and herbicide |
-
1994
- 1994-05-24 DE DE4418096A patent/DE4418096A1/en not_active Withdrawn
-
1995
- 1995-05-06 JP JP53001495A patent/JP4138870B2/en not_active Expired - Lifetime
- 1995-05-06 DE DE59510362T patent/DE59510362D1/en not_active Expired - Lifetime
- 1995-05-06 US US08/737,657 patent/US5902810A/en not_active Expired - Lifetime
- 1995-05-06 ES ES95919422T patent/ES2180633T3/en not_active Expired - Lifetime
- 1995-05-06 CA CA002189131A patent/CA2189131C/en not_active Expired - Lifetime
- 1995-05-06 EP EP95919422A patent/EP0760664B1/en not_active Expired - Lifetime
- 1995-05-06 AT AT95919422T patent/ATE223220T1/en active
- 1995-05-06 WO PCT/EP1995/001731 patent/WO1995031987A1/en active IP Right Grant
- 1995-05-06 PT PT95919422T patent/PT760664E/en unknown
Also Published As
Publication number | Publication date |
---|---|
PT760664E (en) | 2003-01-31 |
DE59510362D1 (en) | 2002-10-10 |
WO1995031987A1 (en) | 1995-11-30 |
ES2180633T3 (en) | 2003-02-16 |
EP0760664B1 (en) | 2002-09-04 |
JP4138870B2 (en) | 2008-08-27 |
US5902810A (en) | 1999-05-11 |
ATE223220T1 (en) | 2002-09-15 |
DE4418096A1 (en) | 1995-11-30 |
JPH10504023A (en) | 1998-04-14 |
CA2189131C (en) | 2007-03-06 |
EP0760664A1 (en) | 1997-03-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20150506 |