CA2190833A1

CA2190833A1 - Detergent composition

Info

Publication number: CA2190833A1
Application number: CA002190833A
Authority: CA
Inventors: Ailsa Pauline Hilary Grieveson; Margaret Jobling; Shiji Shen; Liang Sheng Tsaur
Original assignee: Individual
Current assignee: Unilever PLC
Priority date: 1994-07-19
Filing date: 1995-07-18
Publication date: 1996-02-01
Also published as: BR9508289A; US5661189A; EP0804137A1; ZA955976B; JP3033050B2; JPH10506099A; KR970704420A; AU2934195A; WO1996002225A1; GB9414574D0

Abstract

An aqueous liquid cleansing and moisturising composition comprising a surface active agent selected from anionic, nonionic, zwitterionic and cationic surface active agents, soap and mixtures thereof; a benefit agent having a weight average particle size in the range 50 to 500 microns; and a thickening agent. The thickening agent is added to the benefit agent in amount from 1 to 50 wt.%, based on the benefit agent.

Description

W0 96102225 2 1 9 (~ 8 3 3 ~ 1690 The presen~ invention relates to detergent comoositions suitable for care and personal washing of the skin. In particular, it relates to compositions which are formulated to give mild cleansing and conditioning of the skin.
Compositions formulated to cleanse the skin are well known.
It is also known to formulate products which provide both a 0 r~OAnCin~ and a moisturising benefit.
For example WO 90/13283 discloses a composition comprising an acyl ester of an isethionic acid salt, a long chain fatty acid, a moisturiser ~ ^nt and, optionally, soap5 One of the problems which may be encountered with such dual purpose compositions is that, whilst cleansing may be effective, there is an insllffici~nt level of moisturisi~.
we have found a way of for--~1Arin~ such compositions such that they can deliver effec~ive moisturising, ,nn~lei~.
or protection of the skin.
In WO 94/01085 and 94/01084 the advantage of depositing large particles of petrolatum from soap based c~mroSitir~nc is recognised.
However, ~ccording to wo 94/03152, r~noorn~ with shower gels comprising, a non-soap detergent, c; ~ i cono oil added to condition the skin and cationic polymers, the mAximum average droplet size of the silicone oil tha~ can be used is 2 microns, if product stability is to be r~intAinod.
We have now found that lar~er particles, by parricle is - 35 meant a solid particle or liquid droplet, of benefit agent can be incorporated into surrace active ~-~mtAining WO96/0222s 2 ~ 90833 P~ 690 comppsitions and e~ect ~ e deLiver~f of the benefit agen~
can be achieved :' .he benefit agent is t-hickened.
Thus, according ~ :ne lnvention there is provided an a aueous liquid cleanslng and moisturising composition comprisinçr: -a) a surface active agent selected from anionic, n~minnir, zwitterionic and r~tirnic surface active agents, soap, and mixtures thereof;
b) an benefit agent having a weight average particle size in the range 50 to 500 microns: and c ) a thickening agent, wherein the thi rk~ni n~ agent is added to the benefit agent in amount from 1 to 50 wt~ based on the benefit agent.
The composition is suitable for cleansing and ~moisturising~ conritioning~ or ~~protection~ of the skin. The benefit agent is included in the composition to moisturise, condition and/or protect the skin. sy benefit ~gent~ is meant a substance that softens the skin (stratum corneum) and keeps it soft by retarding the decrease of its water content and/or protects the skin.
Preferred benefit agen~s include :~
a) silicone oils, gums and modifications thereof such as li~ear and cyclic polydimethylqilryon~q;
amino, alkyl alkylaryl and aryl silicone oils;
b) fats and oils including natural fats and oils such as jojoba, soyabean, rice bran, avocado, almond, olive, sesame, persic, castor, coconut, mink oils; cacao fat, beef tallow, lard; hardened oils obtained by hydrogenating the afuL~ i rned Wo 96/0222s 2 1 9 0 8 3 3 PCT/GBgS/01690 oils: ana synthe~ic mono, di and triglycerides such as myr~ st c acid glyceride and 2-ethylhexanoic acid glyceride;
c) waxes such as r~rn~llh~, spermaceti, beeswax, lanolin and derivatives thereof;
d~ hydrophobic plant extracts;
e) hydrorArhrnq such as liquid para~ins, petrolatum, microcrystalline wax, ceresin, squalene, sc~ualane, and mineral oil;
f ~ higher ~atty acids such as lauric, myristic, palmitic, stearic, behenic, oleic, linoleic linolenic, lanolic, isostearic and poly unsaturated ~atty acids (PUFA) acids:
g) higher alcohols such as lauryl, cetyl, steryl, oleyl, behenyl, cholesterol and 2-h~Y~r~nr alcohol;
h) esters such as cetyl octanoate, myristyl lactaee, cetyl lactate, ~ sopropyl myristate, myristyl myrista~e, isopropyl palmi~ate, isopropyl adipate, butyl stearate, decyl oleate, cholesterol isostearate, glycerol monostearate, glycerol distearate, glycerol tristearate, alkyl lactate, ~or example lauryl lactate, alkyl citrate and alkyl tartrate;
i) essential oils such as ~ish oils, mentha, jasmine, camphor, white cedar, bitter orange peel, ryu, turpentine, rinn;lmrn, b~L~" t, citrus unshiu, calamus, pine, lavender, bay, clove, hiba, eucalyptus, lemon, starflower, thyme, ~eppermin~, rose, sage, menthol, cineole, eugenol, citral, citronelle, borneol, l; n:~ 1 ool, geraniol, evening primrose, camphor, thymol, spiran~ol, pinene, limonene and terpenoid oils;
j ) lipids such as choles~erol, ceramides, sucrose esters and pseudo-ceramides as described in European Paten~ Speci~ica~ion No. 556 957;

2~ 2 1 q ~833 ~ 1169~

Ic) vi~amins such as vitamin A and E, and vitamin alkyi esters, nr~ inrJ ~.lose vitamin C alkyl esters;
1~ sunscreens such as oct,~l methoxyl rinn~r~~te (Parsol ~CX: and butyl methoxy benzoyl h~ne ( Parsol 1789 ~;
m~ Phospholipids; and n) mixtures o~ any of the foregoing .~ q~
The benefit agent may be incorporated in a carrier in the compositions of the invention, particularly if it is likely to suf~er detrimental interactionS with other ~ ~-~tq Of the composition. Benefit agents for which such detrimental interactions may occur include lipids: alkyl l~rt~tPq;
sunscreens; esters such as isopropyl palmitate and isopropyl myristate; and vitamins. The carrier can, for example, be a silicone or hydrocarben oil which is not solubilisedJmicellised by the surface active phase and in which the benefit agen~ is relatively soluble.
Particularly preferred benefit agents include qi 1 i crno oils, gums and modifications thereof, esters such as isopropyl palmitate and myristate and alkyl lactates.
The benefit agent is preferably present in amount of from O .1 to 15 wt%, most preferably from 0 . 2 to 10 wt96, more preferably from 0 . 5 to 7 wt% .
An advantage of the composition according ~o the invention is that, during use, it deposits benefit agent onto the skin at a level which results in a perceivable benefit.
Withou~ being bound by theory, it is believed the benefit agent is dispersed into large pools during dilution of the composition in use and these pools deposit readilY onto the

3 5 skin.

~W096/0222~ 21 90833 r l. 1690 In WO g4/oloa4 and WO 94/01085 the ccmposition are structured by the presence cf at least 5Y6 insoluble solid fatty acid soap. -.owever, i~ is believed that such high levels of solid phase material may adversely affect the amount of benefit aqent deposited onto the skin. mus, in the~present invention it is preferred that the composition is subst~ntiAlly free of solid soap, by which is meant the level of solid soap is below lwtY6.
Suitable thiokonin~7 agents for the benefit agent include polacrylates: fumed silica; natural and synthetic waxes, alkyl silicone waxes such as behenyl silicone wax;
aluminium silicate: lanolin derivatlves such as lanesterol;
higher fatty alcohols; polyethylenecopolymers; narogel;
polyammonium stearate; sucrose esters; hydrophobic clays;
petrolatum; hydrotalcites; and mixtures thereof.
Hydrotalcites are ma~erials of general formula [MmNn (OH) ~ ] n~xm~~m"H~O
where M is a divalent me~al ion e . g . Mg:~;
N is a trivalent metal ion e . g. Al~';
X is an exchangeable anion e . g CO.~, NO,-, stearate, clnnimate;
m is the r.umber of divalent metal ions; and n is the number of trivalent metal ions.
Particularly preferred thickening agents for the benefit agent include silica, alkyl silicone waxes, r~r~ffin wax, higher fatty alcohols, pe~roleum jelly and polyethyl onoco~olymers.
.

Whilst some ma~erials can function as both a benefit agent and a thickener therefor lt will be appreciated that the benefit and thickening function cannot be provided by the same~ ~nTrlrnn~n~. .iowever, t wll' ke understood that where ~he nn~Qsition ccmpr:ses ~ o or more benefit agents one of said benefit agents cculd also func~ion as a l-hi nk~nin~
agene .

Preferably the amount of thickening agent is from 4 to 2 wt based on the level of benefit agent.
Although the compositions of the invention may be self-structuring preferably they will also comprise a structurant, i . e. a material added to increase the viscosity at zero shear. Suitable materials include swelling clays, for example laponite; fatty acids and derivatives thereof and, in particular fatty acid monoqlyceride polyglycol ethers; cross-linked polyacrylates such as ~ hnpol (T~) (polymers available from Goodrich);
acrylates and copolymers thereof, polyvinylpyrrolidone and copolymers thereof; polyethylene imines; salts such as sodium chloride and ammonium sulphate; sucrose esters;
gellants; and mixtures thereof.
Of the clays partlcularly preferred are synthetic hec~orite (laponite) clay used in conjunction with an electrolyte salt capable of causing the clay to thicken. Suitable electrolytes include alkali and alkaline earth salts such as halides, am.monium salts and 5l-1ph~tF-c.
The compositions according ~o the invention may also comprise a thickening agent in addition to the thickening agent added to t~e benefit agent, i . e. a material which m7inrninq the viscosity of the composition as the shear rate thereof is increased during use. Suitable materials include cross-linlced polyacrylates such as ~hopol (TN) (polymers available from Goodrich); fatty acids and derivatives thereo~ and, in particular, fatty acid monoglyceride polyglycol ethers; natural gums i~cluding Wo 96/02225 2 1 9 (~ 8 3 3 PCr/GB95/0169Q

alginates, guar, xan~han and polysaccharide derivatives including carboxy methyl cellulose and hydL~ y~ yl guar;
pro~ylene glycols and propylene glycol oleates; salts such as sodium chloride and ammonium sulphate; glycerol S tallowates; and mixtures thereof.
Further examples of structurants and thickeners are given in the Int~rnArit~nAl Cosmetic Ingredient Dicti~-nAry, Fifth Edition, 1993, p1lhlichr.~l by CTF.~ (The Cn rie-, Toiletry i~
Fragrance Association), incorporated herein by reference.
The surface active agent can be selected from any known surfactant suitable for topical A~plication to the human body. Mild surl A~Ants, i . e. surfactants which do not lS damage the stratum corneum, the outer layer of skin, are particularly preferred.
One preferred anionic detergent is fatty acyl isethi~nAre o f f ormula: ==
2 0 RCO~CE~C~.SO,M
where R is an alkyl or alkenyl group of 7 to 21 carbon atoms and ~ is a 501-1hi 1 i cing cation such as sodium, potassium, i illTn or subs~ituted ammonium. Preferably at least three quarters of the RCO groups have 12 to 18 carbon atoms and may be derived f rom coconu~, palm or a coconut~palm blend.
Another preferred anionic detergent is alkyl ether sulphate of formula:
RO (C~.C~.O) ~SO.M
where R is an alkyl group of 8 to 2 carbon a~oms, n ranges from 0.5 to 10, especially from 1.5 to 8, and ~ is a solubilising ca~ion as defined above.
_ _ _ _ _ . _ WO 96/02225 2 1 9 û 8 3 3 pcrlGl39slol69o Other possible anionlc de~ergents include alkyl glyceryl e~her sulpha~e, sulphosucci~a~es, ~aurates, sarcosina~es, sulphoaceta~es, alkyl ,,hospha~e, alkyl phosphate esters and acyl lactyla~e, alkyl glutama~es and mix~ures thereof.

Sulphosuccina~es may ~e monoalkyl suiphosuccinates having the formula: RiO,CC~I2CX ( SO.~q) COaM; and amido-MEA
sulphosuccina~es of the formula:
R5rnN~rT~Ir~,O,rrT~,rtT(SO.M)COiM; wherein Rs ranges from C~-C30 alkyl, preferably C 3-C 5 alkyl and ~ is a solubilising cation .
Sarcosinates are generally indicated by the formula:
R~CON~CH,)CH.CO~M, wherein R; ranges from C~-C,~ alkyl, preferably C i-C 5 alkyl and r~ is a sol~lhil ;c~g cation.
Taurates are generally identified by the formula:
RsCONRCH~CH~SO~M, whereln R; ranges from C,-C.O alkyl, preferably C.~-C. alkyi, R~ r~an~es from C!-C~ alkyl, and M is a solubilising ca~lon.
H~rsh surfac~an~s such as prlmary alkane s~llrhr~ e or alkyl benzene sulphonate will generally be avoided.
Suitable nonionic surface active a~ents inrlude alkyl polysaccharides, ac~obionamides, e~hyleneglycol esters, glycerol monoe~hers, polyhydroxyamides ( glucamide ), primary and secondarY alcohol e~hoxylates, especIally ~he C~ i0 aliphatic alcohols ethoxylated with an averaqe of from l to 20 moles of e~hylene oxide per mole o~ alcohol.
If the surface ac~ve agen~ comprises soap, ~he soap is preferably derived from ma~erials wi~h a C~ ~o C.i subs~an~ially sa~ura~ed carbon chain and, preferablY, is a po~assium soap wi~h a C . ~o C ~ carbon chain.
_ WO 96l02225 2 1 9 ~ 8 3 3 PCTIGB95101690 g Mlxtures of any cf the fsregoir.s surface active agents may also be used.
~he-.surface active agent is preferably present at a level of from 1 to 35 wt~, preferably 3 to 30 wt~.
It is aiso preferable that the composition inr~ Pc from O . 5 to 15 wt~ of a cosurfactant agent with skin-mi 1~in~qS
bPnrfitc~ .Suitable materials are zwitterionic detergents which have an alkyl or alkenyl group of 7 to 18 carbon atoms and comply with an overall structural formula:-O R;
Il I
R --~--C--NH ( C 2~ ) m ] D I X Y

where R~ is alkyl or alkenyl of 7 to 18 carbon atoms;
R2 and R3 are each independently alkyl, hydroxyalkyl or carboxyalkyl of 1 to 3 carbon atoms;
m is 2 ~o 4;
n is 0 or 1;
X is alkylene of 1 to 3 carbon atoms optionally substitu~ed with hydroxyl, and Y is -CO~ or -SO~~.0 Zwitterionic detergents within the above reneral formula include simple betaines of formula:-R
R ~ r~.co~
R;
and amido bet2ines of formula:

Wo 96102zZi~ 2 1 9 0 8 3 3 r~l ~ 1690--R i _ CONH ( CX . ) ~ - r:~.c o R;
where m is 2 or 3.
In both formulae R;, R' an~l Ri are as defined previously.
Rl may, in particular, be a mixture of C.2 and C3, al3~yl groups derived from coconut so that at least hal~, preferably, at least ~hree quareer of the grou2s R1 has l0 to 14 carbon atoms. R~ and R' are preferably methyl.
A further possibility is a sulphobetaine of formula:-R' Ri-~--- (CHl) 3SO3 R;
or R~ :
Rl-CONH (CH~ ) = `~- (CH. ~ 35O3 ~;
where m is 2 or 3, or varian~s of these in which - (CH~) 3SO3 is replaced by OH
3 0 - ~ o, Rl, R3 and R' ir. these f ormulae are as de~ined previously .
Furthermore, ehe benefit agent may also function as a cArrier to deliver efficac~ agents to skin trea~ed with the compositions of the invent on. This roure is particularly useful for deliveri:lg efficacy agents which are ~i ffi clll t to deposi~ onto the skir. or those which suffer rlPtri ~1 interactions with other components in the compositiOn. In such cases the carrler ls a often a sil~ cone or hydrocarbon _ _ _ _ _ = . . . .... , , . , , _ _ .

Wo 96/0222~ 2 1 9 0 ~3 3 3 r~ i690 oil ~hich is not solubilised~micellised by ~he surface ac~ive phase and ~ n which c'-.e ef ~ cacy agen~ is relatively soluble. F~rl oq of such ef~icacy agen~s include anti-viral agen~s; r.ydroxycaprylic acids, pyrrolidone;
carboxylic acids; 2, 4, 4 ' -trichloro-2 ' -hydroxydiphenyl ether (Irgasan DP300); 3,4,4~-trichloroc~rh~n~
salicylic acid; benzoyl peroxide; peL~I ~; essential oils;
germicides and insec~ repellants such as N,N-dimethyl m-toluamide (DEET); and mix~ures thereof.
Compositions of the invention may be formulated as products for washing the skin, for example ~ath or shower gels, hand washing compositions, facial washing li~uids; pre-and post-shaving products; rinse-off, wipe-off and leave-on skin-care products.
The compositions of the invention will generally be pourable li~uids or semi-licruids eg pastes and will preferably have a viscoSity in the range 1000 to 100, 000 mPas measured ac a shear ra~e 10s~: and 25C ;n a Haake Rotoviscometer .~V20 .
The compositions of the inven~ion will preferably e~chibi~ a New~onian viscosity at a shear stress of 0 . 01 Pa, at 25C, o~ at least 5, 000 Pas, preferably srèater than 10, 000 Pas.
The above-mentioned characterist:c viscosi~y mea:-uL~ ts may be determined exactly (as :n the case of the non-zero shear viscosities~ using, ~or example a Carrimed CS~ 100 low stress rheometer or obtained C_om an extrj~ro3~tinn according to the Cross Model, ( see J of the Chemical Engineer, 19~3, paper en~itled nRheology for the Chemical Engineer~ hy H Barnes~ as in the case of zero shear rate.
Other typical c~rnn~n~s of the compositions include opacifiers, preferably 0.7 to 1,0 wt9~; preservatives, ., .. . . . , . . _ _ ,, _ . . _ . , Wo 96/02225 PCT/GB9S/0169d--preferably 0.2 co ~.~ w~ and perfumes, preLera~ly 0.5 to 2.0 wt~.
According to a further aspec~ of the invention there is provided a process for preparing compositions according to the invention comprising:-a) forming a `oase composition comprising at leas~ one surtace active agent selected ~rom anionic, nnni nni r~, zwitterionic and ratinnir surface active agentS, soap and mixtures thereof:
b~ adding a thickening agenc to the benefit agent in an amount Crom 1 to 50%wt, based on the benefit agent;
and c~ mixing the base for~l~tinn o~t step a) with the benefit agent.
The invention will be fur~her illustrated by reference to the following non-limiting examples.
E~Amr~ c In the ' i PC: -~lkylpolyglucoside was 21antaren 2000 ex E~enkel Eehenyl alcohol was Nacol 22-97 ex Condea.
3ehenyl silicone wax was Cire 71649 ex P~one Poulenc.
Coco amidopropyl betaine was Amonyl ~A 380 ex SeppiC.
Cross-linked polyacr~late was C~rhnpr,l ETD 2020 ex Goodri ch .
Guar h~dLu~yuLu~1 trimonium rhlorirlP was Jaguar C-13-S ex eyhall .
~ydrotalcite was hydrotalcite rnrt~inin~ IPP, r~ultigel IPP
ex Guilini Chemie GmbH
'PP (isopro~yl palmitate) was ESTOL 1517 ex rTnich WO96/02225 2 1 9 0~33 p~ cl690 Lauryl lacta~e was C~odamol LL ex C_oda Chemicals.
MEA suphosuccina~e was wi~co 5690 ex Wi~co.
Polyethylene AC617 was from A-C Performance Additives.
sil~ca was a hydrophobically modified silica, Aerosil R972 ex Degussa.
The silicone oils were all DC200, a polydimethylqil~ n-~ ex Dow Corning, bu~ with a varying viscosities as stated below .
Si 1 i ~nnF- oil o"~i-1 cinn was RC 92/057 ex R~ nn .
Sodium lauryl ether sulphate was Genapol ZRO ex E~oechst E le I
In this example, the effect of thickening a sili~~nne~ oil benefit agent with silica on the deposition of silicone oil onto the skin was examined .
The following me~hod was used to de~ermine the amount of benefit agen~ deposited on~o full ~h;t~kn~cs porcine skin (5 x 15 cm) treated with composi~ions according to the invention .
The skin was prehydrated and then 0 . 5 ml of the product applied to it. The product was lathered for 10 seconds and then rinsed for 10 seconds under running wa~er.
Thereaf ter the skin was wiped once with a paper ~owel to remove excess water.
2 minutes after drying a strip of adhesive tape was pressed onto the skin for ~0 seconds by applying a const~nt load o~
lOOg. cm~ . The adhesive ~ape employed was ,J-Lar Superclear (T/q) ~ape having a width of 2 . 5cm. In total ten strips of tape were applied to adjacent sites on ~he skin.

Wo96/02Z25 2 1 90833 ~ . i6911 m this test procedure silicone which has deposieed on ehe skin will subsecluenel~ be transferred to ehe ~ape along with some of the outer layer of the skin.
The amounts of silicon and skin adhering to the tape are determined by means of X-ray fluorescence spectroscopy.
The tape strips are placed in an X-ray fluorescence speceromeeer with the adhesive side facing ehe beam of ehis machine. A mask is applied over the tape eo define a standardised area ln ehe middle of ehe tape which is exposed to the X-ray beam. The sample chamber of the machine is placed under vacuum before making mea2,uL, c and the spectrometer is then used to measure the quantieies of silicon and sulphur. The sulphur is repr~q~nt~rive of the amount of skin which has transferred to the tape.
The amounes of silicon and sul~hur observed with a clean ~iece of adhesive tape are subtraceed from ehe experimental mea"uL, q. The experimeneal measurements for the average levels of sulphur and silicon are expressed as a raeio of silicon to suIphur. From this raeio it is possible to deeermine silicone oil deposition per unit area o skin.
A base shower gel formulation having the following composition was prepared, 9~ wt sodium lauryl ether sulphate ~ . oo Sodium coco amido propyl betaine l. 00 30 ~lkylpolyglucoside ~ 5 00 Sorbic acid o . 37 T_isodium cierate dihyaraee 0.9,9 Cross-linked polyacrylate o.g ~h_ckener~ -l 35 SN NaOH -l 1~ter + minors to l00 W096/02225 21 90~33 r~ (;S~

~ ~hi rkPnPr added to glve t~e required viscosity ~ -SoO0mPas at 10s~; and 25C~
s~ NaOX was added to adj~st the pE~ of the composition to pH 5.3.

The composition was prepared by ~; qpprsi nr the polyacrylate in excess wa~er. Thereaf~er sorbic acid and trisodium citrate dihydrate were added to the resulting polymer dispersion. The three surface active agents were mixed and the resulting mix added to the polymer dispersion.
Thereafter minors were added. The viscosity of the resulting ~-gitinn was measured at a shear rate of 10s~
at 2SC and thi rkPnPr added until the required viscosity nh t :~1 i n Pci Two Harvard 44 syringe pumps were used to infuse the base formlll qti~r,n and the benefit agent, silicone oil. ~ nnP
oil was present at a level of 5 wt% based on the total composition. One syringe was ~illed with the base fnrm~ ti nn and the other with silicone oil. The syringes were then inserted into the syringe pum;;~ and the infusion rate set at S:9S oil:base. The oil and base were forced through a static in-line mixer and a composition with oil particles of the rer~uired size obtained. The size of the particles can be controlled by the diameter of the static mixer, the flow rate and length of the mixer tube. The size of the particles can be determined using a ~alvern ~astersizer .
Silicone deposition ~rom the compositions ~rror~9ing to the invention was measured by the test procedure described above and compared with that ~~om a similar composit;on~ ~A) comprising a silicone oil P~-l1 qion having a viscositY of 50000 mPas at 10s~ and 25C

21 908.33 Wo 96/02225 r~ ,vl690 Comparar,ive Composition (Composi~ion A) wt 5Sodium lauryl ether sulphate 13 0 0 Coco 2midopropy1 betaine (CAPB) 2 00 ,C1 1 i ~-nnP oil omlll ci ~n 5, oo ~uar h~d-u,~ u~ ~l trimonium 0 10 chloride lOSorbic acid 0 37 50dium citrate dihydrate o 49 Sodium chloridet -2 Citric acid" -0 01 Water + minors to 100 level can be varied in order to give the required viscosity o~ 5000 mP2s at lOs~' and 25C
i~ level can be varied in order to give the required pH
The ~ollowing results were obtained Silica Si s ~art:cle ~dded ~a~Q cize/l m Comparison 0 0 9 o 5 25 Ia 8 3 63 9 424 b 9 7 22 2 354 c 4 7 21 3 341 Id 6 1 11 5 289 The results demons~ra~e the advantage, ~ n terms o~
deposition o~ silicone, using a composi~ion comprising a thi t~kPnP~l Ci 1 i cnne oil over a composition Comprising a unthi ckened _ i 1 j ~nn ~ oil Wo96/0~225 21 q0833 r~ /Cl690 FXAm'~ 1 e T _ Example I was repeated except tha~ ehe benefit agent used , was IPP (isopropylpalmitate). ~he IPP was thickened with S three dif ferent thi r1~nors at a level of 10% by weight based on the IPP.
The following method was used to ~l~t~rmi n~ the amount of IPP deposited onto full thi rkn~-qg porcine skin ( 5 x 15cm pieces ) treated with compositions according to the invention. The skin was treated and washed with the compositions according to the invention by the same meehod as described for example I. Thereafter the skin was extracted with ethanol three times ( 3 ml per extract ~ and lS the extract made up to lOg and submitted for Gas ~' to~raphy analysis to determine the amount of IPP
depos i t ed .
The following results were obtained:-th; ckon~r d~nosition~nm none 6.1 polyethylene AC617 g41. 9 behenyl qi 1 i cnn~ wax 138 .1 25 hydrotalcite 55.1 The results demonstrate the increased deposition of IPP
obtained when the IPP is thickened.
30 F~Amrle ITI
In this example the benef it agent used was lauryl lactate .
The following method was used to determine the amount of lauryl lactate deposited onto skin treated with compositions according to the i~vention cnn~Aininr, lauryl lactate .

-- l8 --Porcine full thickn~cs skin was prehydrated and then 0.20g of the product and O . 8g of water applied to it. The skin was washed for 30 seconds and then rinsed for 10 seconds under runnin~ water.

Thereaf ter the skin was wiped once with a paper towel to ren70ve excess water. 30 5econds after drying 5 strips of Des~uame tape were applied to the skin sequ~nti~l ly for 10 seconds .
The strips were then removed from the skin and hydrolysed in 2ml of NaOEI (0.5~) at 60C for 60 minutes. They were then neutralised with 2ml ~Cl ( O . SM) and in Sorensens rhn~7rhAre buf~er (p~ 7 . O) . T~e total lauryl lactate and the protein content of the tapes, representative of the lauryl lactzte transferred to the skin, was determined using Sigma diagnostic assay Kits 735/10 and 690. A
solution cnnt~i ni ng the assay and treated strips was prepared and the absorbance at 540nm measured in a W
spectrometer.
The ~7ase formulation for ~he ~ollowing experiments was:-Wt 9~
MEA sulphosucclnate 11.7 Cross-li~7ked polyacrylate O, 3 Sodium cocoyl isethionate 8. 5 Coco amidoPropyl betaine 15 . 8 Water and minors to 100 It was prépared by dispersing the polyacrylate in excess water. A premix of the t3nree surfactants was then added to the polymer dispersion. Thereafter minors were added.
The ~o7 l -in~J benefit agent~thickener c0m~7ination was used: -wo 96l02Z25 2 1 9 0 8 3 3 P~l,. 1690 _ 19 _ Dro~let size~um X Lauryl lac~ate a5 172 . 2 Polyethylene AC617 15 The mixture x was prepared by heating the two ~-~tc together to a temperature of -110C to melt in the polyethylene. The mixture was then allowed to cool before being used.
An: lcion of the base fn~ll~ti~,n and thickened benefit agent, was applied to the skin using the tese p.L,ced,..e, described above.
The following results were obtained:-lac~ate/Ahcorh~n~~e l~nits ~X10-3~
Untreaeed skin 81 base ~or~ aeion (no lauryl laceate) 63 base + 5%'X 128 base + 5~ lauryl lactate 102 base + 10%~X 15~
base + 10% lauryl lactate 107 ~ based on the total composition In a separate set o~ experimentS, but with the same base formulation as described above, the effect of a range of thickening agents ~all at a level of 5%wt based on the lauryl lactate) on the deposition of lauryl lactate was oY~Tni nod . The lauryl lactate or t~ickened laurYl lactate was added to the base ~ormulation a~ a level of 5wt~.

~ 90833 Wo 96/02225 ~ 1690--lactate/Ah~orh~nre ~ln;tS ~x10-3!
lauryl lactate (no ~hickener) 112 lauryl lactate + paraf ~in wax 148 5lauryl lacta~e + behenyl alcohol 152 lauryl lactate + petroleum j elly 14a lauryl lactate + polyethylene AC617 129 lauryl lactate + behenyl silicone wax 167 The results demonstrate the benefit o~ thi rkl~ni n'J the bene~it agent with a thickening aç~ent

Claims

- 21 -

1. An aqueous liquid cleansing and moisturising composition comprising:
a) a surface active agent selected from anionic, nonionic, zwitterionic and cationic surface active agents, soap and mixtures thereof;
b) an benefit agent having a weight average particle size in the range 50 to 500 microns; and c) a thickening agent, the composition being subantially free of solid soap, and wherein the thickening agent is added to the benefit agent in amount from 1 to 50%wt, based on the benefit agent.

2. A composition according to claim 1 wherein the thickening agent is selected from polyacrylates; silica, natural and synthetic waxes, alkyl silicone waxes;
aluminium silicate; lanolin derivatives; higher fatty alcohols; polyethylenecopolymers; narogel; polyammonium stearate; sucrose esters; hydrophobic clays; petrolatum;
hydrotalcites; and mixtures thereof.

3. A composition according to claim 1 wherein the composition is structured with a structurant selected from the swelling clays; cross-linked polyacrylates; acrylates and copolymers thereof; polyvinylpyrrolidone and copolymers thereof; polyethylene imines; salts; sucrose esters; and gellants.

4. A composition according to claim 1 wherein the benefit agent is selected from silicone oils; gums; fats; oils;
waxes; hydrophobic plant extracts; hydrocarbons; fatty acids: alcohols: esters; essential oils: lipids phospholipids; vitamins: sunscreens; and mixtures thereof.

5. A composition according to any one of the preceding claims comprising 0.1 to 15 wt% of the benefit agent.

6. A composition according to any one of the preceding claims wherein the benefit agent functions as a carrier to deliver efficacy agents to skin treated with the composition.

7. A composition according to any one of the preceding claims comprising 1 to 35 wt% of the surface active agent.

8. A composition according to any one of the preceding claims further comprising a cosurfactant selected from betaines, amidobetaines and sulphobetaines.

9. A process for preparing a composition according to claim 1 comprises:-a) forming a base composition comprising at least one surface active agent selected from anionic, nonionic, zwitterionic and cationic surface active agents, soap and mixtures thereof:
b) adding a thickening agent to the benefit agent in an amount from 1 to 50 wt%, based on the benefit agent; and c) mixing the base formulation of step a) with the benefit agent.

10. A method of depositing a benefit agent from an aqueous liquid cleasing and moisturising composition, the method comprising providing the said benefit agent in a composition comprising:

a) a surface active agent selected from anionic, nonionic, zwitterionic and cationic surface active agents, soap and mixtures thereof;
b) an benefit agent having a weight average particle size in the range 50 to 500 microns: and c) a thickening agent, and wherein the thickening agent is added to the benefit agent in amount from 1 to 50% wt, based on the benefit agent.