CA2193836A1 - Vascular treatment method and apparatus - Google Patents
Vascular treatment method and apparatusInfo
- Publication number
- CA2193836A1 CA2193836A1 CA002193836A CA2193836A CA2193836A1 CA 2193836 A1 CA2193836 A1 CA 2193836A1 CA 002193836 A CA002193836 A CA 002193836A CA 2193836 A CA2193836 A CA 2193836A CA 2193836 A1 CA2193836 A1 CA 2193836A1
- Authority
- CA
- Canada
- Prior art keywords
- congener
- blood vessel
- administering
- coronary blood
- extravascularly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/104—Balloon catheters used for angioplasty
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0587—Epicardial electrode systems; Endocardial electrodes piercing the pericardium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
- A61N1/303—Constructional details
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
- A61N1/303—Constructional details
- A61N1/306—Arrangements where at least part of the apparatus is introduced into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/105—Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/12—Blood circulatory system
- A61M2210/122—Pericardium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1002—Balloon catheters characterised by balloon shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M29/00—Dilators with or without means for introducing media, e.g. remedies
- A61M29/02—Dilators made of swellable material
Abstract
A method and apparatus for treating blood vessels in a mammal, particularly humans, especially coronary blood vessels (3), for vascular thrombosis and angioplasty restenosis, thereby to decrease incidence of vessel re-thrombosis (3'), unstable angina and myocardial infarction, by administering (11, 15) a congener of an endothelium-derived bioactive agent, especially a nitrovasodilator, including one or more of nitric oxide or a nitric oxide donor agent, such as sodium nitroprusside and nitroglycerin, to an extravascular treatment site (4) at a therapeutically effective dosage rate.
Claims (23)
1. A method of treating blood vessels in a mammal, which comprises administering a congener of an endothelium-derived bioactive agent to an extravascular treatment site at a therapeutically effective dosage rate.
2. The method of claim 1 in which said congener is prostacyclin, prostaglandin E1, or a nitrovasodilator.
3. The method of claim 2 in which said nitrovasodilator is nitric oxide or a nitric oxide donor agent.
4. The method of claim 3 in which said nitric oxide donor agent is L-arginine, sodium nitroprusside or nitroglycerin, or a combination thereof.
5. The method of claim 1 in which said congener is sodium nitroprusside.
6. The method of claim 1 in which said treatment site is a coronary blood vessel.
7. The method of claim 6 in which said treatment site is a coronary artery.
8. The method of claim 6 in which said treatment site is a vein graft for arterial bypass.
9. The method of claim 1 in which said step of administering includes deliveringsaid congener in a controlled manner over a sustained period of time.
10. The method of claim 6 in which said step of administering comprises intrapericardially extravascularly delivering said congener to said coronary blood vessel.
11. The method of claim 10 in which said step of administering comprises intrapericardially infusing said congener through a percutaneously inserted catheter extravascularly to said coronary blood vessel.
12. The method of claim 6 in which said step of administering comprises transpericardially extravascularly delivering said congener to said coronary blood vessel.
13. The method of claim 12 in which said step of administering comprises transpericardially infusing said congener through a percutaneously inserted catheter extravascularly to said coronary blood vessel.
14. The method of claim 12 in which said step of administering comprises iontophoretically delivering said congener transpericardially extravascularly to said coronary blood vessel,
IS. The method of claim 6 in which said step of administering comprises inserting extravascularly to said coronary blood vessel an implant capable of extended time release of said congener.
16. The method of claim 15 in which said step of inserting said extravascular implant comprises percutaneously inserting said implant proximately adjacent, onto, or into the pericardial sac surrounding the heart.
17. The method of claim 15 in which step of inserting said extravascular implantcomprises surgically wrapping said implant around a vein graft used for an arterial bypass.
18. The method of claim 15 in which said extravascular implant is a biodegradable controlled-release polymer comprising said congener.
19. The method of claim 1 in which said dosage rate is effective to provide one or more of the therapeutic effects of promotion of vasodilation, inhibition of vessel spasm, inhibition of platelet aggregation, inhibition of vessel thrombosis, and inhibition of platelet growth factor release, at said treatment sites, without inducing systemic hypotension or anticoagulation.
20. The method of claim 1 in which said dosage rate is from about 0.1 to about 3.0 µg/kg/min.
21. A method of treating a coronary blood vessel in a mammal, which comprises intrapericardially or transpericardially supplying sodium nitroprusside to the blood vessel in a therapeutically effective dose.
22. A method of treating the heart, which comprises administering a cardio-active or cardio-vascular active drug from the pericardial space.
23. The method of claim 22 in which said drug is selected from vasodilator, antiplatelet, anticoagulant, thrombolytic, anti-inflammatory, antiarrhythmic, inotropic, antimitotic, angiogenic, antiatherogenic and gene therapy agents.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/264,458 US5681278A (en) | 1994-06-23 | 1994-06-23 | Coronary vasculature treatment method |
US08/264,458 | 1994-06-23 | ||
PCT/US1995/009055 WO1996000112A1 (en) | 1994-06-23 | 1995-06-23 | Vascular treatment method and apparatus |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2193836A1 true CA2193836A1 (en) | 1996-01-04 |
CA2193836C CA2193836C (en) | 2010-03-30 |
Family
ID=23006161
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2193836A Expired - Fee Related CA2193836C (en) | 1994-06-23 | 1995-06-23 | Vascular treatment method and apparatus |
Country Status (8)
Country | Link |
---|---|
US (2) | US5681278A (en) |
EP (1) | EP0766580B1 (en) |
JP (1) | JPH10507092A (en) |
AT (1) | ATE318164T1 (en) |
AU (2) | AU3134495A (en) |
CA (1) | CA2193836C (en) |
DE (1) | DE69534798T2 (en) |
WO (2) | WO1996000038A1 (en) |
Families Citing this family (229)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6161543A (en) | 1993-02-22 | 2000-12-19 | Epicor, Inc. | Methods of epicardial ablation for creating a lesion around the pulmonary veins |
US5891459A (en) * | 1993-06-11 | 1999-04-06 | The Board Of Trustees Of The Leland Stanford Junior University | Enhancement of vascular function by modulation of endogenous nitric oxide production or activity |
US5861168A (en) * | 1993-06-11 | 1999-01-19 | The Board Of Trustees Of The Leland Stanford Junior University | Intramural delivery of nitric oxide enhancer for inhibiting lesion formation after vascular injury |
US5852058A (en) * | 1993-06-11 | 1998-12-22 | The Board Of Trustees Of The Leland Stanford Junior University | Intramural delivery of nitric oxide enhancer for inhibiting lesion formation after vascular injury |
US6152141A (en) * | 1994-07-28 | 2000-11-28 | Heartport, Inc. | Method for delivery of therapeutic agents to the heart |
US6425881B1 (en) * | 1994-10-05 | 2002-07-30 | Nitrosystems, Inc. | Therapeutic mixture useful in inhibiting lesion formation after vascular injury |
US6239172B1 (en) * | 1997-04-10 | 2001-05-29 | Nitrosystems, Inc. | Formulations for treating disease and methods of using same |
US20110196039A9 (en) * | 1994-10-05 | 2011-08-11 | Kaesemeyer Wayne H | Controlled release arginine formulations |
US5968983A (en) * | 1994-10-05 | 1999-10-19 | Nitrosystems, Inc | Method and formulation for treating vascular disease |
US6063407A (en) * | 1995-02-16 | 2000-05-16 | The General Hospital Corporation | Treatment of vascular thrombosis and restenosis with inhaled nitric oxide |
US6409722B1 (en) | 1998-07-07 | 2002-06-25 | Medtronic, Inc. | Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue |
US5897553A (en) | 1995-11-02 | 1999-04-27 | Medtronic, Inc. | Ball point fluid-assisted electrocautery device |
US6322548B1 (en) | 1995-05-10 | 2001-11-27 | Eclipse Surgical Technologies | Delivery catheter system for heart chamber |
US5827216A (en) | 1995-06-07 | 1998-10-27 | Cormedics Corp. | Method and apparatus for accessing the pericardial space |
US5797870A (en) * | 1995-06-07 | 1998-08-25 | Indiana University Foundation | Pericardial delivery of therapeutic and diagnostic agents |
US5900433A (en) * | 1995-06-23 | 1999-05-04 | Cormedics Corp. | Vascular treatment method and apparatus |
US6283951B1 (en) * | 1996-10-11 | 2001-09-04 | Transvascular, Inc. | Systems and methods for delivering drugs to selected locations within the body |
EP1264601A3 (en) * | 1995-11-01 | 2003-11-12 | Chiron Corporation | Treatment of a coronary condition by delivery of therapeutics to the pericardial space |
WO1997016169A1 (en) * | 1995-11-01 | 1997-05-09 | Chiron Corporation | Treatment of a cardiovascular indication by delivery of therapeutics to the pericardial space |
DE69637676D1 (en) * | 1995-11-09 | 2008-10-23 | Univ R | Use of locally administered lysines to IMPROVE VASCULAR FUNCTION |
US9289618B1 (en) | 1996-01-08 | 2016-03-22 | Impulse Dynamics Nv | Electrical muscle controller |
JP4175662B2 (en) | 1996-01-08 | 2008-11-05 | インパルス ダイナミクス エヌ.ヴイ. | Electric muscle control device |
US7167748B2 (en) | 1996-01-08 | 2007-01-23 | Impulse Dynamics Nv | Electrical muscle controller |
US8825152B2 (en) | 1996-01-08 | 2014-09-02 | Impulse Dynamics, N.V. | Modulation of intracellular calcium concentration using non-excitatory electrical signals applied to the tissue |
US8321013B2 (en) | 1996-01-08 | 2012-11-27 | Impulse Dynamics, N.V. | Electrical muscle controller and pacing with hemodynamic enhancement |
US9713723B2 (en) | 1996-01-11 | 2017-07-25 | Impulse Dynamics Nv | Signal delivery through the right ventricular septum |
US6258032B1 (en) * | 1997-01-29 | 2001-07-10 | William M. Hammesfahr | Method of diagnosis and treatment and related compositions and apparatus |
US7840264B1 (en) | 1996-08-19 | 2010-11-23 | Mr3 Medical, Llc | System and method for breaking reentry circuits by cooling cardiac tissue |
US7908003B1 (en) | 1996-08-19 | 2011-03-15 | Mr3 Medical Llc | System and method for treating ischemia by improving cardiac efficiency |
US7052493B2 (en) | 1996-10-22 | 2006-05-30 | Epicor Medical, Inc. | Methods and devices for ablation |
US6237605B1 (en) | 1996-10-22 | 2001-05-29 | Epicor, Inc. | Methods of epicardial ablation |
US6311692B1 (en) | 1996-10-22 | 2001-11-06 | Epicor, Inc. | Apparatus and method for diagnosis and therapy of electrophysiological disease |
US6805128B1 (en) | 1996-10-22 | 2004-10-19 | Epicor Medical, Inc. | Apparatus and method for ablating tissue |
US6840936B2 (en) | 1996-10-22 | 2005-01-11 | Epicor Medical, Inc. | Methods and devices for ablation |
US6719755B2 (en) | 1996-10-22 | 2004-04-13 | Epicor Medical, Inc. | Methods and devices for ablation |
US6206004B1 (en) | 1996-12-06 | 2001-03-27 | Comedicus Incorporated | Treatment method via the pericardial space |
ATE449836T1 (en) | 1997-02-10 | 2009-12-15 | Harvard College | METHOD FOR MODULATING HEMATOPOASIS AND VASCULAR GROWTH |
US6045565A (en) * | 1997-11-04 | 2000-04-04 | Scimed Life Systems, Inc. | Percutaneous myocardial revascularization growth factor mediums and method |
US6086582A (en) * | 1997-03-13 | 2000-07-11 | Altman; Peter A. | Cardiac drug delivery system |
US6443949B2 (en) * | 1997-03-13 | 2002-09-03 | Biocardia, Inc. | Method of drug delivery to interstitial regions of the myocardium |
US6511477B2 (en) | 1997-03-13 | 2003-01-28 | Biocardia, Inc. | Method of drug delivery to interstitial regions of the myocardium |
CA2225013C (en) | 1997-04-04 | 2006-06-06 | Institut Du N.O. Inc. | Injection system for delivery of a gaseous substance |
US5984908A (en) * | 1997-04-10 | 1999-11-16 | Chase Medical Inc | Venous return catheter having integral support member |
US6273913B1 (en) * | 1997-04-18 | 2001-08-14 | Cordis Corporation | Modified stent useful for delivery of drugs along stent strut |
US6004295A (en) * | 1997-06-26 | 1999-12-21 | An-Go-Gen Inc. | Catheters |
AU3458197A (en) * | 1997-07-16 | 1999-02-10 | Impulse Dynamics N.V. | Smooth muscle controller |
US6096037A (en) | 1997-07-29 | 2000-08-01 | Medtronic, Inc. | Tissue sealing electrosurgery device and methods of sealing tissue |
JP2001513495A (en) * | 1997-08-08 | 2001-09-04 | デューク ユニバーシティ | Compositions, devices and methods that facilitate surgical procedures |
US6711436B1 (en) | 1997-08-08 | 2004-03-23 | Duke University | Compositions, apparatus and methods for facilitating surgical procedures |
US5972013A (en) * | 1997-09-19 | 1999-10-26 | Comedicus Incorporated | Direct pericardial access device with deflecting mechanism and method |
US6592552B1 (en) | 1997-09-19 | 2003-07-15 | Cecil C. Schmidt | Direct pericardial access device and method |
US6436365B2 (en) * | 1997-09-23 | 2002-08-20 | Schering Aktiengesellschaft | Process for therapeutic treatment of proliferative diseases |
US8709007B2 (en) | 1997-10-15 | 2014-04-29 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Devices and methods for ablating cardiac tissue |
EP1037621A4 (en) | 1997-10-15 | 2004-01-21 | Univ Jefferson | Nitric oxide donor compositions, methods, apparatus, and kits for preventing or alleviating vasoconstriction or vasospasm in a mammal |
US6749617B1 (en) | 1997-11-04 | 2004-06-15 | Scimed Life Systems, Inc. | Catheter and implants for the delivery of therapeutic agents to tissues |
US6575956B1 (en) | 1997-12-31 | 2003-06-10 | Pharmasonics, Inc. | Methods and apparatus for uniform transcutaneous therapeutic ultrasound |
US7921855B2 (en) * | 1998-01-07 | 2011-04-12 | Asthmatx, Inc. | Method for treating an asthma attack |
US6221425B1 (en) | 1998-01-30 | 2001-04-24 | Advanced Cardiovascular Systems, Inc. | Lubricious hydrophilic coating for an intracorporeal medical device |
US6296630B1 (en) | 1998-04-08 | 2001-10-02 | Biocardia, Inc. | Device and method to slow or stop the heart temporarily |
US6527767B2 (en) * | 1998-05-20 | 2003-03-04 | New England Medical Center | Cardiac ablation system and method for treatment of cardiac arrhythmias and transmyocardial revascularization |
US6231518B1 (en) | 1998-05-26 | 2001-05-15 | Comedicus Incorporated | Intrapericardial electrophysiological procedures |
JP2002516134A (en) | 1998-05-26 | 2002-06-04 | コメディカス・インコーポレーテッド | Endocardial treatment method and device |
US6706039B2 (en) | 1998-07-07 | 2004-03-16 | Medtronic, Inc. | Method and apparatus for creating a bi-polar virtual electrode used for the ablation of tissue |
US6537248B2 (en) | 1998-07-07 | 2003-03-25 | Medtronic, Inc. | Helical needle apparatus for creating a virtual electrode used for the ablation of tissue |
US6152911A (en) * | 1998-08-27 | 2000-11-28 | Chase Medical, Inc. | Venous return catheter having multiple helical support members |
CA2341683C (en) * | 1998-09-11 | 2015-07-21 | President And Fellows Of Harvard College | Regulation of lung tissue by hedgehog-like polypeptides, and formulations and uses related thereto |
US8308719B2 (en) | 1998-09-21 | 2012-11-13 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Apparatus and method for ablating tissue |
US8700161B2 (en) | 1999-03-05 | 2014-04-15 | Metacure Limited | Blood glucose level control |
US9101765B2 (en) | 1999-03-05 | 2015-08-11 | Metacure Limited | Non-immediate effects of therapy |
US8019421B2 (en) * | 1999-03-05 | 2011-09-13 | Metacure Limited | Blood glucose level control |
US8666495B2 (en) | 1999-03-05 | 2014-03-04 | Metacure Limited | Gastrointestinal methods and apparatus for use in treating disorders and controlling blood sugar |
US6319244B2 (en) | 1999-03-16 | 2001-11-20 | Chase Medical, L.P. | Catheter with flexible and rigid reinforcements |
US6488689B1 (en) * | 1999-05-20 | 2002-12-03 | Aaron V. Kaplan | Methods and apparatus for transpericardial left atrial appendage closure |
US7190997B1 (en) * | 1999-06-04 | 2007-03-13 | Impulse Dynamics Nv | Drug delivery device |
US7092753B2 (en) * | 1999-06-04 | 2006-08-15 | Impulse Dynamics Nv | Drug delivery device |
AU774185B2 (en) * | 1999-06-05 | 2004-06-17 | Board Of Trustees Of The Leland Stanford Junior University | Method and composition for inhibiting cardiovascular cell proliferation |
US6746481B1 (en) | 1999-06-28 | 2004-06-08 | Medtronic, Inc. | Implatable device including a polyamino acid component |
CA2377583A1 (en) | 1999-07-19 | 2001-01-25 | Epicor, Inc. | Apparatus and method for ablating tissue |
US7288096B2 (en) | 2003-01-17 | 2007-10-30 | Origin Medsystems, Inc. | Apparatus for placement of cardiac defibrillator and pacer |
US7398781B1 (en) | 1999-08-10 | 2008-07-15 | Maquet Cardiovascular, Llc | Method for subxiphoid endoscopic access |
US7597698B2 (en) | 1999-08-10 | 2009-10-06 | Maquet Cardiovascular Llc | Apparatus and method for endoscopic encirclement of pulmonary veins for epicardial ablation |
US6569082B1 (en) | 1999-08-10 | 2003-05-27 | Origin Medsystems, Inc. | Apparatus and methods for cardiac restraint |
US7526342B2 (en) | 1999-08-10 | 2009-04-28 | Maquet Cardiovascular Llc | Apparatus for endoscopic cardiac mapping and lead placement |
US20030187460A1 (en) * | 1999-08-10 | 2003-10-02 | Chin Albert K. | Methods and apparatus for endoscopic cardiac surgery |
US20030187461A1 (en) * | 1999-08-10 | 2003-10-02 | Chin Albert K. | Releasable guide and method for endoscopic cardiac lead placement |
US20060287574A1 (en) * | 1999-08-25 | 2006-12-21 | Chin Albert K | Longitudinal dilator |
US6587718B2 (en) * | 1999-10-08 | 2003-07-01 | Scimed Life Systems, Inc. | Iontophoretic delivery to heart tissue |
US20050154370A1 (en) | 1999-10-29 | 2005-07-14 | Medtronic, Inc. | Methods and systems for providing therapies into the pericardial space |
US20040121942A1 (en) * | 1999-11-02 | 2004-06-24 | Kenneth Chien | Method for inhibition of phospholamban activity for the treatment of cardiac disease and heart failure |
US20030229331A1 (en) * | 1999-11-05 | 2003-12-11 | Pharmasonics, Inc. | Methods and apparatus for uniform transcutaneous therapeutic ultrasound |
AU2623201A (en) * | 1999-12-30 | 2001-07-16 | Kam W Leong | Controlled delivery of therapeutic agents by insertable medical devices |
US8221402B2 (en) | 2000-01-19 | 2012-07-17 | Medtronic, Inc. | Method for guiding a medical device |
US7706882B2 (en) | 2000-01-19 | 2010-04-27 | Medtronic, Inc. | Methods of using high intensity focused ultrasound to form an ablated tissue area |
ATE460951T1 (en) * | 2000-01-25 | 2010-04-15 | Edwards Lifesciences Corp | RELEASE SYSTEMS FOR THE TREATMENT OF RESTENOSIS AND ANASTOMOTIC INTIMAL HYPERPLASIA |
US8048070B2 (en) | 2000-03-06 | 2011-11-01 | Salient Surgical Technologies, Inc. | Fluid-assisted medical devices, systems and methods |
US6478776B1 (en) | 2000-04-05 | 2002-11-12 | Biocardia, Inc. | Implant delivery catheter system and methods for its use |
US6514250B1 (en) | 2000-04-27 | 2003-02-04 | Medtronic, Inc. | Suction stabilized epicardial ablation devices |
AU2001253654A1 (en) | 2000-04-27 | 2001-11-12 | Medtronic, Inc. | Vibration sensitive ablation apparatus and method |
US7498304B2 (en) * | 2000-06-16 | 2009-03-03 | Curis, Inc. | Angiogenesis-modulating compositions and uses |
AU7549501A (en) * | 2000-06-16 | 2002-01-02 | Biogen Inc | Angiogenesis-modulating compositions and uses |
US6685672B1 (en) | 2000-07-13 | 2004-02-03 | Edwards Lifesciences Corporation | Multi-balloon drug delivery catheter for angiogenesis |
WO2002017809A1 (en) * | 2000-08-29 | 2002-03-07 | Kaplan Aaron V | Methods and apparatus for transpericardial left atrial appendage closure |
US6726920B1 (en) | 2000-09-22 | 2004-04-27 | Durect Corporation | Implantable drug delivery patch |
US6690970B1 (en) | 2000-10-06 | 2004-02-10 | Syde A. Taheri | Biological pacemaker and implantation catheter |
US6926669B1 (en) | 2000-10-10 | 2005-08-09 | Medtronic, Inc. | Heart wall ablation/mapping catheter and method |
US20050084514A1 (en) * | 2000-11-06 | 2005-04-21 | Afmedica, Inc. | Combination drug therapy for reducing scar tissue formation |
EP1341476A2 (en) * | 2000-12-01 | 2003-09-10 | Nephros Therapeutics, Inc. | Intrasvascular drug delivery device and use therefor |
US6692458B2 (en) * | 2000-12-19 | 2004-02-17 | Edwards Lifesciences Corporation | Intra-pericardial drug delivery device with multiple balloons and method for angiogenesis |
US20040138621A1 (en) | 2003-01-14 | 2004-07-15 | Jahns Scott E. | Devices and methods for interstitial injection of biologic agents into tissue |
US7740623B2 (en) | 2001-01-13 | 2010-06-22 | Medtronic, Inc. | Devices and methods for interstitial injection of biologic agents into tissue |
US6699240B2 (en) | 2001-04-26 | 2004-03-02 | Medtronic, Inc. | Method and apparatus for tissue ablation |
US6663627B2 (en) | 2001-04-26 | 2003-12-16 | Medtronic, Inc. | Ablation system and method of use |
US7959626B2 (en) | 2001-04-26 | 2011-06-14 | Medtronic, Inc. | Transmural ablation systems and methods |
US6807968B2 (en) | 2001-04-26 | 2004-10-26 | Medtronic, Inc. | Method and system for treatment of atrial tachyarrhythmias |
EP1383447A4 (en) * | 2001-04-27 | 2007-04-04 | Medstar Res Inst | Stent-based delivery of statins to prevent restenosis |
JP2003007916A (en) * | 2001-06-19 | 2003-01-10 | Sanyo Electric Co Ltd | Method of manufacturing circuit device |
US8934968B2 (en) * | 2001-08-03 | 2015-01-13 | Cardiac Pacemakers, Inc. | Neurostimulation and coronary artery disease treatment |
US7481759B2 (en) * | 2001-08-03 | 2009-01-27 | Cardiac Pacemakers, Inc. | Systems and methods for treatment of coronary artery disease |
JP4341907B2 (en) | 2001-09-05 | 2009-10-14 | セイリアント・サージカル・テクノロジーズ・インコーポレーテッド | Fluid-assisted medical device, system and method |
US20030077310A1 (en) * | 2001-10-22 | 2003-04-24 | Chandrashekhar Pathak | Stent coatings containing HMG-CoA reductase inhibitors |
US6936040B2 (en) * | 2001-10-29 | 2005-08-30 | Medtronic, Inc. | Method and apparatus for endovenous pacing lead |
US7967816B2 (en) | 2002-01-25 | 2011-06-28 | Medtronic, Inc. | Fluid-assisted electrosurgical instrument with shapeable electrode |
US6889091B2 (en) | 2002-03-06 | 2005-05-03 | Medtronic, Inc. | Method and apparatus for placing a coronary sinus/cardiac vein pacing lead using a multi-purpose side lumen |
US7610104B2 (en) * | 2002-05-10 | 2009-10-27 | Cerebral Vascular Applications, Inc. | Methods and apparatus for lead placement on a surface of the heart |
US7118566B2 (en) | 2002-05-16 | 2006-10-10 | Medtronic, Inc. | Device and method for needle-less interstitial injection of fluid for ablation of cardiac tissue |
US7294143B2 (en) | 2002-05-16 | 2007-11-13 | Medtronic, Inc. | Device and method for ablation of cardiac tissue |
JP4265888B2 (en) * | 2002-06-12 | 2009-05-20 | 株式会社リコー | Image forming apparatus |
GB0222522D0 (en) | 2002-09-27 | 2002-11-06 | Controlled Therapeutics Sct | Water-swellable polymers |
US7083620B2 (en) | 2002-10-30 | 2006-08-01 | Medtronic, Inc. | Electrosurgical hemostat |
US11439815B2 (en) | 2003-03-10 | 2022-09-13 | Impulse Dynamics Nv | Protein activity modification |
JP2006519663A (en) | 2003-03-10 | 2006-08-31 | インパルス ダイナミックス エヌヴイ | Apparatus and method for delivering electrical signals for regulating gene expression in heart tissue |
US7497857B2 (en) | 2003-04-29 | 2009-03-03 | Medtronic, Inc. | Endocardial dispersive electrode for use with a monopolar RF ablation pen |
US8792985B2 (en) | 2003-07-21 | 2014-07-29 | Metacure Limited | Gastrointestinal methods and apparatus for use in treating disorders and controlling blood sugar |
US7846168B2 (en) | 2003-10-09 | 2010-12-07 | Sentreheart, Inc. | Apparatus and method for the ligation of tissue |
US20080085329A1 (en) * | 2003-10-22 | 2008-04-10 | Fred Hutchinson Cancer Research Center, Inc. | Methods, Compositions and Devices for Inducing Stasis in Cells, Tissues, Organs, and Organisms |
US20050165452A1 (en) * | 2004-01-28 | 2005-07-28 | Medtronic, Inc. | Antithrombogenic medical device |
US7186214B2 (en) * | 2004-02-12 | 2007-03-06 | Medtronic, Inc. | Instruments and methods for accessing an anatomic space |
US20050192210A1 (en) * | 2004-03-01 | 2005-09-01 | Rothbard Jonathan B. | Compositions and methods for treating diseases |
US11779768B2 (en) | 2004-03-10 | 2023-10-10 | Impulse Dynamics Nv | Protein activity modification |
US8352031B2 (en) | 2004-03-10 | 2013-01-08 | Impulse Dynamics Nv | Protein activity modification |
WO2005087295A2 (en) * | 2004-03-18 | 2005-09-22 | Ino Medics Ltd. | Delivery of nitric oxide to a blood vessel |
EP1730280B1 (en) * | 2004-03-26 | 2018-10-24 | Curis, Inc. | Rna interference modulators of hedgehog signaling and uses thereof |
WO2005107765A2 (en) * | 2004-05-05 | 2005-11-17 | Cormedics Corporation | Heart treatment method |
US8333764B2 (en) | 2004-05-12 | 2012-12-18 | Medtronic, Inc. | Device and method for determining tissue thickness and creating cardiac ablation lesions |
WO2005112812A1 (en) | 2004-05-14 | 2005-12-01 | Medtronic, Inc. | Method and devices for treating atrial fibrillation by mass ablation |
US20050266042A1 (en) * | 2004-05-27 | 2005-12-01 | Medtronic Vascular, Inc. | Methods and apparatus for treatment of aneurysmal tissue |
WO2005120374A1 (en) | 2004-06-02 | 2005-12-22 | Medtronic, Inc. | Compound bipolar ablation device and method |
ATE516762T1 (en) | 2004-06-02 | 2011-08-15 | Medtronic Inc | ABLATION AND STAPLE INSTRUMENT |
EP1750608B1 (en) | 2004-06-02 | 2012-10-03 | Medtronic, Inc. | Ablation device with jaws |
WO2005120375A2 (en) | 2004-06-02 | 2005-12-22 | Medtronic, Inc. | Loop ablation apparatus and method |
US8409219B2 (en) | 2004-06-18 | 2013-04-02 | Medtronic, Inc. | Method and system for placement of electrical lead inside heart |
US8663245B2 (en) | 2004-06-18 | 2014-03-04 | Medtronic, Inc. | Device for occlusion of a left atrial appendage |
US8926635B2 (en) * | 2004-06-18 | 2015-01-06 | Medtronic, Inc. | Methods and devices for occlusion of an atrial appendage |
GB0417401D0 (en) | 2004-08-05 | 2004-09-08 | Controlled Therapeutics Sct | Stabilised prostaglandin composition |
EP1827571B1 (en) | 2004-12-09 | 2016-09-07 | Impulse Dynamics NV | Protein activity modification |
WO2006099244A1 (en) * | 2005-03-11 | 2006-09-21 | Hong Kong Nitric Oxide Limited | Combination therapy for endothelial dysfunction, angina and diabetes |
US8244371B2 (en) | 2005-03-18 | 2012-08-14 | Metacure Limited | Pancreas lead |
WO2006110734A2 (en) | 2005-04-07 | 2006-10-19 | Sentreheart, Inc. | Apparatus and method for the ligation of tissue |
US8822535B2 (en) * | 2005-04-20 | 2014-09-02 | Fred Hutchinson Cancer Research Center | Methods, compositions and articles of manufacture for enhancing survivability of cells, tissues, organs, and organisms |
EP1898991B1 (en) | 2005-05-04 | 2016-06-29 | Impulse Dynamics NV | Protein activity modification |
US8932208B2 (en) | 2005-05-26 | 2015-01-13 | Maquet Cardiovascular Llc | Apparatus and methods for performing minimally-invasive surgical procedures |
US20070010781A1 (en) * | 2005-06-27 | 2007-01-11 | Venkataramana Vijay | Implantable aorto-coronary sinus shunt for myocardial revascularization |
CN101563097A (en) * | 2005-11-14 | 2009-10-21 | 企业合伙人风险资本公司 | Stem cell factor therapy for tissue injury |
EP1989144A4 (en) | 2006-02-02 | 2014-01-29 | Innovative Bio Therapies | An extracorporeal cell-based therapeutic device and delivery system |
US20080039746A1 (en) | 2006-05-25 | 2008-02-14 | Medtronic, Inc. | Methods of using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions |
GB0613333D0 (en) | 2006-07-05 | 2006-08-16 | Controlled Therapeutics Sct | Hydrophilic polyurethane compositions |
GB0613638D0 (en) | 2006-07-08 | 2006-08-16 | Controlled Therapeutics Sct | Polyurethane elastomers |
US20080039362A1 (en) * | 2006-08-09 | 2008-02-14 | Afmedica, Inc. | Combination drug therapy for reducing scar tissue formation |
US20080085293A1 (en) * | 2006-08-22 | 2008-04-10 | Jenchen Yang | Drug eluting stent and therapeutic methods using c-Jun N-terminal kinase inhibitor |
GB0620685D0 (en) | 2006-10-18 | 2006-11-29 | Controlled Therapeutics Sct | Bioresorbable polymers |
US8012143B1 (en) | 2006-12-12 | 2011-09-06 | Pacesetter, Inc. | Intrapericardial delivery tools and methods |
PL2574287T3 (en) | 2007-03-30 | 2015-10-30 | Sentreheart Inc | Devices for closing the left atrial appendage |
US20080294175A1 (en) * | 2007-05-21 | 2008-11-27 | Epitek, Inc. | Left atrial appendage closure |
WO2008147678A1 (en) * | 2007-05-21 | 2008-12-04 | Epitek, Inc. | Left atrial appendage closure |
US20090036965A1 (en) * | 2007-07-30 | 2009-02-05 | Robert Glenmore Walsh | Conjunctive stent therapy |
US20090036875A1 (en) * | 2007-07-30 | 2009-02-05 | Robert Glenmore Walsh | Cardiac tissue therapy |
EP3272297B1 (en) | 2007-09-20 | 2020-04-22 | Sentreheart, Inc. | Devices for remote suture management |
EP2209517A4 (en) | 2007-10-05 | 2011-03-30 | Maquet Cardiovascular Llc | Devices and methods for minimally-invasive surgical procedures |
US20090170933A1 (en) * | 2007-12-26 | 2009-07-02 | Cook Incorporated | Method for removing a medical device from a spasmodic constriction in a bodily passageway |
JP5443386B2 (en) | 2007-12-28 | 2014-03-19 | サリエント・サージカル・テクノロジーズ・インコーポレーテッド | Fluid-assisted electrosurgical device, method and system |
US8821488B2 (en) | 2008-05-13 | 2014-09-02 | Medtronic, Inc. | Tissue lesion evaluation |
US9603674B2 (en) * | 2008-05-30 | 2017-03-28 | The Regents Of The University Of California | Method to protect the esophagus and other mediastinal structures during cardiac and thoracic interventions |
EP2291515A2 (en) | 2008-06-18 | 2011-03-09 | Innovative Biotherapies, Inc. | Methods for propagation of renal precursor cells |
ES2440751T3 (en) * | 2008-10-07 | 2014-01-30 | Boston Scientific Scimed, Inc. | Medical devices for administration of therapeutic agents to body lumens |
US20100094277A1 (en) * | 2008-10-09 | 2010-04-15 | Olympus Medical Systems Corp. | High-frequency surgical device and method |
US11660430B2 (en) * | 2008-10-10 | 2023-05-30 | Peter Forsell | Heart assisting device |
JP5855460B2 (en) | 2008-11-24 | 2016-02-09 | ヴァスキュラー グラフト ソリューションズ リミテッド | External stent |
US9254168B2 (en) | 2009-02-02 | 2016-02-09 | Medtronic Advanced Energy Llc | Electro-thermotherapy of tissue using penetrating microelectrode array |
WO2010096809A1 (en) | 2009-02-23 | 2010-08-26 | Salient Surgical Technologies, Inc. | Fluid-assisted electrosurgical device and methods of use thereof |
WO2010105081A1 (en) * | 2009-03-13 | 2010-09-16 | Medtronic, Inc. | Method of treating heart failure |
JP5612073B2 (en) | 2009-04-01 | 2014-10-22 | センターハート・インコーポレイテッドSentreHEART, Inc. | Tissue ligation apparatus and its operation |
WO2011031299A1 (en) * | 2009-08-28 | 2011-03-17 | Mount Sinai School Of Medicine Of New York University | Intrapericardial injections |
CN102497832B (en) | 2009-09-08 | 2015-09-09 | 显著外科技术公司 | For case assembly and the using method thereof of electro-surgical device, electrosurgical unit |
EP2351529B1 (en) * | 2010-01-27 | 2019-06-05 | Aeeg Ab | Post operative wound support device |
WO2011092710A2 (en) | 2010-02-01 | 2011-08-04 | Metacure Limited | Gastrointestinal electrical therapy |
EP2544616B1 (en) | 2010-03-11 | 2017-09-06 | Medtronic Advanced Energy LLC | Bipolar electrosurgical cutter with position insensitive return electrode contact |
WO2011129893A1 (en) | 2010-04-13 | 2011-10-20 | Sentreheart, Inc. | Methods and devices for treating atrial fibrillation |
EP2422823B1 (en) * | 2010-07-30 | 2014-03-19 | Institut Quimic De Sarria | Bioactive implant |
US20110295249A1 (en) * | 2010-05-28 | 2011-12-01 | Salient Surgical Technologies, Inc. | Fluid-Assisted Electrosurgical Devices, and Methods of Manufacture Thereof |
US9138289B2 (en) | 2010-06-28 | 2015-09-22 | Medtronic Advanced Energy Llc | Electrode sheath for electrosurgical device |
US8920417B2 (en) | 2010-06-30 | 2014-12-30 | Medtronic Advanced Energy Llc | Electrosurgical devices and methods of use thereof |
US8906012B2 (en) | 2010-06-30 | 2014-12-09 | Medtronic Advanced Energy Llc | Electrosurgical devices with wire electrode |
US9023040B2 (en) | 2010-10-26 | 2015-05-05 | Medtronic Advanced Energy Llc | Electrosurgical cutting devices |
US9427281B2 (en) | 2011-03-11 | 2016-08-30 | Medtronic Advanced Energy Llc | Bronchoscope-compatible catheter provided with electrosurgical device |
US10052218B2 (en) | 2011-04-18 | 2018-08-21 | Vascular Graft Solutions Ltd. | Devices and methods for deploying implantable sleeves over blood vessels |
CN103747751B (en) | 2011-06-08 | 2016-12-28 | 森特里心脏股份有限公司 | Knot of tissue bundling device and tensioner thereof |
US9750565B2 (en) | 2011-09-30 | 2017-09-05 | Medtronic Advanced Energy Llc | Electrosurgical balloons |
US8870864B2 (en) | 2011-10-28 | 2014-10-28 | Medtronic Advanced Energy Llc | Single instrument electrosurgery apparatus and its method of use |
US9277905B2 (en) * | 2012-08-02 | 2016-03-08 | W. L. Gore & Associates, Inc. | Space-filling device |
WO2014127278A2 (en) * | 2013-02-18 | 2014-08-21 | Elutin, Inc. | Site specific drug delivery wraps, systems and methods of use thereof |
EP3378416B1 (en) | 2013-03-12 | 2020-07-29 | Sentreheart, Inc. | Tissue ligation devices |
US20140276054A1 (en) * | 2013-03-15 | 2014-09-18 | Volcano Corporation | Piezoelectric-Actuated Fluid-Delivery Devices and Associated Systems and Methods |
US9526503B2 (en) * | 2013-08-12 | 2016-12-27 | W. L. Gore & Associates, Inc. | Lumbar ostia occlusion devices and methods of deploying the same |
EP3062711B1 (en) | 2013-10-31 | 2023-06-21 | AtriCure, Inc. | Devices for left atrial appendage closure |
US10842988B2 (en) * | 2014-06-02 | 2020-11-24 | Medtronic, Inc. | Over-the-wire delivery of a substernal lead |
US9974599B2 (en) | 2014-08-15 | 2018-05-22 | Medtronic Ps Medical, Inc. | Multipurpose electrosurgical device |
WO2016154488A2 (en) | 2015-03-24 | 2016-09-29 | Sentreheart, Inc. | Tissue ligation devices and methods therefor |
CN107530070B (en) | 2015-03-24 | 2021-09-28 | 森特里心脏股份有限公司 | Device and method for left atrial appendage closure |
US20170042551A1 (en) | 2015-08-13 | 2017-02-16 | The Brain Protection Company PTY LTD | Implantable damping devices for treating dementia and associated systems and methods of use |
US11389227B2 (en) | 2015-08-20 | 2022-07-19 | Medtronic Advanced Energy Llc | Electrosurgical device with multivariate control |
US11051875B2 (en) | 2015-08-24 | 2021-07-06 | Medtronic Advanced Energy Llc | Multipurpose electrosurgical device |
US10433870B2 (en) | 2015-10-08 | 2019-10-08 | Medtronic, Inc. | Interventional medical systems and methods for delivering a medical electrical lead to an epicardial implant site |
US10327812B2 (en) | 2015-11-04 | 2019-06-25 | Rainbow Medical Ltd. | Pericardial access device |
US10716612B2 (en) | 2015-12-18 | 2020-07-21 | Medtronic Advanced Energy Llc | Electrosurgical device with multiple monopolar electrode assembly |
JP7137472B2 (en) | 2016-02-26 | 2022-09-14 | センターハート・インコーポレイテッド | Device and method for left atrial appendage closure |
WO2018057963A1 (en) | 2016-09-23 | 2018-03-29 | Sentreheart, Inc. | Devices and methods for left atrial appendage closure |
US10194975B1 (en) | 2017-07-11 | 2019-02-05 | Medtronic Advanced Energy, Llc | Illuminated and isolated electrosurgical apparatus |
US10667842B2 (en) | 2017-11-24 | 2020-06-02 | Rainbow Medical Ltd. | Pericardial needle mechanism |
US11844526B2 (en) | 2018-03-27 | 2023-12-19 | Atricure, Inc. | Devices and methods for left atrial appendage closure |
Family Cites Families (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3923060A (en) * | 1974-04-23 | 1975-12-02 | Jr Everett H Ellinwood | Apparatus and method for implanted self-powered medication dispensing having timing and evaluator means |
US4003379A (en) * | 1974-04-23 | 1977-01-18 | Ellinwood Jr Everett H | Apparatus and method for implanted self-powered medication dispensing |
US4250878A (en) * | 1978-11-22 | 1981-02-17 | Motion Control, Inc. | Non-invasive chemical species delivery apparatus and method |
DK149080C (en) * | 1980-06-06 | 1986-07-28 | Sankyo Co | METHOD FOR PREPARING ML-236B CARBOXYLIC ACID DERIVATIVES |
US4411648A (en) * | 1981-06-11 | 1983-10-25 | Board Of Regents, The University Of Texas System | Iontophoretic catheter device |
US4423725A (en) * | 1982-03-31 | 1984-01-03 | Baran Ostap E | Multiple surgical cuff |
DE3325797A1 (en) * | 1983-07-16 | 1985-01-31 | Natec Inst Naturwiss | Balloon-tipped catheter, especially an endotracheal catheter |
ZA85332B (en) * | 1984-01-20 | 1985-09-25 | Cedars Sinai Medical Center | Method of treatment of the myocardium and catheter for retroinfusion of pharmacologic agents |
US4809707A (en) * | 1985-04-12 | 1989-03-07 | Kvm Engineering, Inc. | Electrode for non-invasive allergy testing |
US4637815A (en) * | 1985-08-06 | 1987-01-20 | Lemole Gerald M | Irrigational hemostatic solution |
ATE84419T1 (en) * | 1985-09-24 | 1993-01-15 | Item Dev Ab | CONTINUOUS INTRAVENOUS INFUSION OF ADENOSIN IN HUMAN PATIENTS, UNIT DOSAGE FORM OF ADENOSIN AND ITS USE IN PHARMACEUTICAL PRODUCTION. |
JPS63502112A (en) * | 1986-01-03 | 1988-08-18 | コンソリデイテツド・フアーマシユーテイカルズ・リミテツド | Melphalan derivative |
JPH06696B2 (en) * | 1987-01-27 | 1994-01-05 | 積水化学工業株式会社 | Tape preparation |
US5167960A (en) * | 1988-08-03 | 1992-12-01 | New England Deaconess Hospital Corporation | Hirudin-coated biocompatible substance |
US5069662A (en) * | 1988-10-21 | 1991-12-03 | Delcath Systems, Inc. | Cancer treatment |
US5212165A (en) * | 1989-10-23 | 1993-05-18 | E. R. Squibb & Sons, Inc. | Method for rehabilitating the vasorelaxant action of the coronary arteries impaired through atherosclerosis or hypercholesterolemia employing an ace inhibitor |
US5100392A (en) * | 1989-12-08 | 1992-03-31 | Biosynthesis, Inc. | Implantable device for administration of drugs or other liquid solutions |
US5163905A (en) * | 1990-01-12 | 1992-11-17 | Don Michael T Anthony | Regional perfusion dissolution catheter |
US5176638A (en) * | 1990-01-12 | 1993-01-05 | Don Michael T Anthony | Regional perfusion catheter with improved drug delivery control |
US5236413B1 (en) * | 1990-05-07 | 1996-06-18 | Andrew J Feiring | Method and apparatus for inducing the permeation of medication into internal tissue |
US5140012A (en) * | 1990-05-31 | 1992-08-18 | E. R. Squibb & Sons, Inc. | Method for preventing onset of restenosis after angioplasty employing pravastatin |
WO1991019529A1 (en) * | 1990-06-15 | 1991-12-26 | Cortrak Medical, Inc. | Drug delivery apparatus and method |
US5279546A (en) * | 1990-06-27 | 1994-01-18 | Lake Region Manufacturing Company, Inc. | Thrombolysis catheter system |
US5178608A (en) * | 1990-09-24 | 1993-01-12 | Advanced Biomedical Devices, Inc. | Balloon catheter with expandable inflation member |
JPH04330012A (en) * | 1991-01-24 | 1992-11-18 | Kitsuen Kagaku Kenkyu Zaidan | Coronary vasodilator |
US5318531A (en) * | 1991-06-11 | 1994-06-07 | Cordis Corporation | Infusion balloon catheter |
US5222936A (en) * | 1991-09-25 | 1993-06-29 | Stephen Robert L | Intracorporeal iontophoretic method |
JPH0596012A (en) * | 1991-10-07 | 1993-04-20 | Olympus Optical Co Ltd | Thermotherapic device |
US5304120A (en) * | 1992-07-01 | 1994-04-19 | Btx Inc. | Electroporation method and apparatus for insertion of drugs and genes into endothelial cells |
US5278192A (en) * | 1992-07-02 | 1994-01-11 | The Research Foundation Of State University Of New York | Method of vasodilator therapy for treating a patient with a condition |
US5298018A (en) * | 1992-08-14 | 1994-03-29 | Pdt Cardiovascular, Inc. | Method for treating cardiovascular disease through adjunctive photodynamic therapy |
US5650447A (en) * | 1992-08-24 | 1997-07-22 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nitric oxide-releasing polymers to treat restenosis and related disorders |
US5405919A (en) * | 1992-08-24 | 1995-04-11 | The United States Of America As Represented By The Secretary Of Health And Human Services | Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders |
US5403834A (en) * | 1992-12-07 | 1995-04-04 | Eukarion, Inc. | Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease |
US5421818A (en) * | 1993-10-18 | 1995-06-06 | Inner Ear Medical Delivery Systems, Inc. | Multi-functional inner ear treatment and diagnostic system |
US5397307A (en) * | 1993-12-07 | 1995-03-14 | Schneider (Usa) Inc. | Drug delivery PTCA catheter and method for drug delivery |
-
1994
- 1994-06-23 US US08/264,458 patent/US5681278A/en not_active Expired - Fee Related
-
1995
- 1995-06-07 US US08/486,104 patent/US5634895A/en not_active Expired - Fee Related
- 1995-06-23 WO PCT/US1995/009047 patent/WO1996000038A1/en active Application Filing
- 1995-06-23 JP JP8503514A patent/JPH10507092A/en active Pending
- 1995-06-23 EP EP95927258A patent/EP0766580B1/en not_active Expired - Lifetime
- 1995-06-23 AU AU31344/95A patent/AU3134495A/en not_active Abandoned
- 1995-06-23 WO PCT/US1995/009055 patent/WO1996000112A1/en active IP Right Grant
- 1995-06-23 CA CA2193836A patent/CA2193836C/en not_active Expired - Fee Related
- 1995-06-23 AT AT95927258T patent/ATE318164T1/en not_active IP Right Cessation
- 1995-06-23 DE DE69534798T patent/DE69534798T2/en not_active Expired - Lifetime
- 1995-06-23 AU AU31340/95A patent/AU3134095A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU3134095A (en) | 1996-01-19 |
DE69534798T2 (en) | 2006-10-26 |
WO1996000112A1 (en) | 1996-01-04 |
WO1996000038A1 (en) | 1996-01-04 |
EP0766580A1 (en) | 1997-04-09 |
EP0766580A4 (en) | 2001-06-27 |
JPH10507092A (en) | 1998-07-14 |
US5681278A (en) | 1997-10-28 |
CA2193836C (en) | 2010-03-30 |
DE69534798D1 (en) | 2006-04-27 |
US5634895A (en) | 1997-06-03 |
AU3134495A (en) | 1996-01-19 |
EP0766580B1 (en) | 2006-02-22 |
ATE318164T1 (en) | 2006-03-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2193836A1 (en) | Vascular treatment method and apparatus | |
US5941868A (en) | Localized intravascular delivery of growth factors for promotion of angiogenesis | |
Bates et al. | A monoclonal antibody against the platelet glycoprotein IIb/IIIa receptor complex prevents platelet aggregation and thrombosis in a canine model of coronary angioplasty. | |
US5112305A (en) | Catheter device for intramural delivery of therapeutic agents | |
US7381731B2 (en) | Pharmaceutical composition comprising citrulline | |
KR0156597B1 (en) | Method and composition for ameliorating tissue damage due to ischemia and reperfusion | |
Grech et al. | Termination of reperfusion arrhythmia by coronary artery occlusion. | |
Maksimenko et al. | The combination of modified antioxidant enzymes for anti-thrombotic protection of the vascular wall: the significance of covalent connection of superoxide dismutase and catalase activities | |
Capurro et al. | Aspirin-induced increase in collateral flow after acute coronary occlusion in dogs. | |
Goldberg et al. | Combination therapy for evolving myocardial infarction: Intracoronary thrombolysis and percutaneous transluminal angioplasty | |
WO1998030255A9 (en) | Localized intravascular delivery of antioxidant substances for inhibition of restenosis in recanalized blood vessels | |
Klevan et al. | Coronary vasospasm culminating in thromboels and infarction following “successful” coronary angioplasty | |
Knight et al. | Interrelationships between prostanoids and skin flap survival: a review | |
Schumacher et al. | Streptokinase thrombolysis in experimental coronary artery thrombosis: pattern of reflow and effect of a stenosis | |
Rentrop et al. | Recanalization of Coronary Arteries by Thrombolytic Agents in Acute Myocardial Infarction | |
Beyersdorf | Protection of evolving myocardial infarction and failed PTCA | |
Kerensky et al. | Lysis of intravascular thrombus prior to coronary stenting using the dispatch infusion catheter | |
Werter et al. | Coronary reperfusion with a new catheter in six patients with acute occlusion after angioplasty | |
Friedman | Early interventions in the management of acute uncomplicated myocardial infarction. | |
WO1999002219A1 (en) | Method and system for the intramural delivery of radioactive agents | |
Meerbaum | Surgical modes of retroperfusion | |
Betriu et al. | Thrombolysis in Acute Myocardial Infarction | |
SU1695929A1 (en) | Method of myocardial infarction treatment | |
Haneda et al. | Coronary sinus norepinephrine level during angina pectoris induced by atrial pacing | |
Numano et al. | Effects of thromboxane A2 (TXA2) on hemodynamic and biochemical parameters of canine hearts |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20140625 |