CA2193964A1 - Thin layer ablation apparatus - Google Patents

Thin layer ablation apparatus

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Publication number
CA2193964A1
CA2193964A1 CA002193964A CA2193964A CA2193964A1 CA 2193964 A1 CA2193964 A1 CA 2193964A1 CA 002193964 A CA002193964 A CA 002193964A CA 2193964 A CA2193964 A CA 2193964A CA 2193964 A1 CA2193964 A1 CA 2193964A1
Authority
CA
Canada
Prior art keywords
electrolytic solution
ablation apparatus
inner layer
electrodes
organ
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002193964A
Other languages
French (fr)
Inventor
James Baker
Chris Jones
Kee S. Lee
Phillip Sommer
Bruno Strul
Stuart D. Edwards
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2193964A1 publication Critical patent/CA2193964A1/en
Abandoned legal-status Critical Current

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    • A61B18/12Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14Probes or electrodes therefor
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Abstract

An apparatus for ablating an inner layer in an organ or lumen of a body, or any desired thin layer. The ablation apparatus includes a balloon-like expandable member (12) (the balloon hereinafter) having an interior section for housing an electrolytic solution, a conforming member (20) made of a material such as a resilient foam rubber (the foam rubber hereinafter).
Capable of substantially conforming to a portion of the inner layer of the organ. The foam rubber delivering the electrolytic solution housed within the balloon to the inner layer of the organ, one or more electrodes (39, 41) positioned in or on the foam rubber for delivering RF energy to the inner layer of the organ, an electrical connector device connecting the one or more electrodes to an RF energy source and an electrolytic solution delivery tube for delivering the electrolytic solution from the electrolytic solution source to the balloon. The apparatus may also include a feedback device which monitors a characteristic of the inner layer and, in response, controls the delivery of RF energy to the one or more electrodes. The one or more electrodes may be positioned in or on the foam rubber for delivering RF energy to the inner layer of the organ, each electrode including an insulator formed on a surface of the electrode. The foam rubber may also include "non"-zone areas with a first porosity rate for delivering electrolytic solution to the inner layer and zone areas for housing an electrode and electrolytic solution, the zone areas having a second porosity rate that is less than the first porosity rate such that the electrolytic solution passes through the zone areas at a slower rate than through the non-zone areas. The ablation apparatus may also include a membrane positioned between the balloon and the foam rubber, the membrane adapted to receive the electrolytic solution from the balloon and deliver the electrolytic solution to the foam rubber.

Description

~ W096/00042 - .2~ q3~5 ~ P~

THINLAYERAPLATIONAPPARATUS

BACKGROUND OF THE INVENTION
F.~l..li..~lsl~. to Copending ADplir:ltir~n This n,, ' , is a continuation of U.S. Patent Application Serial No. 08/319,373 entitled "Th.n LayerAblation Apparatus" by Baker, et al, filed October 6, 1994, which is a continuation-in-part of U.S. Patent Application Serial No. 08/286,862 entitled "Thin Layer Ablation Apparatus"
by Edwards, et al, filed August 4, 1994, which is a continuation-in-part of U.S. Patent Application Serial No.08/272,162 entitled "Thin Layer Ablation Apparatus" by Edwards, et al, filed July 7, 1994, which is a continuation-in-part of U.S. Patent Application Serial No. 081265,459 entitled "Thin Layer Ablation Apparatus" by Edwards, filed June 24, 1994, all of which are i,,,,o,,uu, ' by reference.
Field of the Invention This invention relates generally to an ablation apparatus for the selective ablation of the inner layers of body organs or lumens, and more particularly, to an ablation apparatus which includes an t3A,uanddule member housing a heated electrolytic solution.

Description of Related Art There are a number of body organs and lumens, including but not limited to the uterus, gall bladder, large intestine and the like, that have inner layers which have abnormal conditions. Traditional methods of treatment have included removal of the body organ to treat the abnommal condition, the use of lasers, and the ,, l! , of a themmal source.
A diseased condition of the uterus""enu"l,d~id, is defined as excessive menstrual bleeding in the absence of organic pathology. It has no known aetiology and it has been pos~' ' that it is due to an wos6~00042 2 1 93964 I~ . . 12 iUdU,UI U~UI idL~: exposure of the endometnum to hommones. Menou hdyia is an e,~,eeui"yly common problem, typically ~.UIII,~ ill9 dl,J,UlUA;III ' Iy one in five outpatient referrals to gyneculoyi.,al d~pdl l" ,~, Ib. Women suffering severe Ill~nu,lllayid are at risk from chronic anemia. The first treatment employed may be the admi~ dliun of drug therapy. A major disadvantage is the need to administer drugs long temm, and frequently the beneficial effects are only temporary. Another treatment is hy~k:lt.,Lul u y.
A number of physical and chemical methods have been tried as : " lldli~C., to h~ lullly, including the use of supell,~ ' ' steam, cryotherapy, urea injection and radium packing. The most commonly used methods as an : " l l ~ c to hy~ ,Lu,, ,y are, ablation of the e:udu~ LIium either by using a laser, such as a Nd:YAG laser, or the use of RF energy applied with an electrode.
Laser L,. Mlellts have provided only limited success. RF is an attractive alternative. In RF heating, a conductive probe is placed within the uterine cavity and an insulated ground-plane electrode or belt is placed around the patient's midriff. RF energy is applied to the themmal probe with the external belt electrode acting as the retum arm of the circuit. The electrical load presented by the RF themmal probe, patient, and external belt is matched to the output of the RF generator via a tuning unit, to fomm a series resonant circuit. Once tuned, the majonty of the power applied to the probe is deposited into the endometrium as heat.
Current flows primarily capacitively, and an electric field is set up around the active tip of the probe. Tissue Iying within the field becomes heated because of rapid oscillation of charged particles and locally induced currents.
Prior, et al. reported on the use of RF to treat Il l~l ,o" h dyid. Power at 27 ~ 12 MHz was delivered to a probe that was placed into the uterine cavity and capacitively coupled to a second electrode consisting of a belt placed around the patient, Prior, et al., Int. J. I Iyp~ Ll ,~" ";,. 7:2 213-220 w096/00042 2 1 93964 r;~

(1990). The active electrode was a 10 mm diameter stainless-steel cylinder with a length of 70 mm. This method however did not adequately deliver RF energy to the entire endu",~t,i-lm. Because the t:~du~ tdum has an irregular surface it is difficult to deliver sufficient RF energy to the entire structure to effectively treat I l lel 101 l h dyid.
It is desirable to have close contact between the RF conductive face and the endometrium. In U.S. Patent No. 5 277 201 an ~ l..Ll UCUI ~ iuctive ,Udl l idble balloon is expanded into the interior of the uterus and effects electrical contact with the t:" iu, "t:LI idN ining to be destroyed . The devicehowever fails to provide sufficient physical contact with the entire endu",~t,ium. As a result treatment of the endu,,,eLIidl lining is not complete. Not only is the physical contact with the endc.",~ ',ium Ul I ~dLi:~rd~.lUiy, a more effective delivery of RF energy to the ~:, ,du, "~ t, ium is also needed.
There is a need for an RF ablation apparatus that provides more suitable collru""dtiu,1 with a iining of a body organ such as the endometrium of the uterus. There is also a need for the effective delivery of RF energy to the endo",~L~i-Jm as well as other interior layers of body organs.
There is also a need for an ablation device for the ~" iu",~t ium which includes a feedback Illl:uhd~ .ll that is l~:a,uull,/c to detected ulldlc~uL~ Lils of the ~:"ic",~t,ium and the delivered RF selectable distributed energy is adjusted in response to the feedback.
There is also need for an ablation device which provides controlled and selectable distributed energy to a selected tissue site such as the endo" ~t~ ium.
There is also a need for an RF ablation apparatus with an open foam cell structure surrounding an ~X~Jdll idbl~ member that includes zones of semi-trapped electrolytic solution adjacent to electrodes with a zone porosity that is less than non-zone sections of the open foam cell W096/00042 2 ~ 93964 foam where there aren't electrodes. Additionally, there is a need for an ablation device which provides a heated electrolytic solution in the pdnddL)le member that is delivered to the inner layer of a body organ or lumen.

SU~ ~ A A L~y OF THE INVENTION
Accordingly, an object of the invention is to provide an ablation apparatus suitable for interior thin walled areas of body organs.
Another object of the invention is to provide an ablation apparatus that effectively conforms to the shape of the interior of a body organ.
Yet another object of the invention is to provide an ablation apparatus with the cullfuullilld member that effectively conforms to the shape of the interior of a body organ or lumen, and delivers heated electrolytic solution to a target tissue site.
Stili a further object of the invention is to provide an ablation apparatus that includes a plurality of electrodes positioned in the cu,,'~ lg member, and heated el~ ,lyt;u solution is passed from an interior of an ~xpdllddbl~ member sunrounded by the cul~fullllill~ member to the inner lining of an organ or lumen in order to reduce the amount of time required for ablation.
A further object of the invention is to provide an ablation apparatus with expanded electrodes by pOaitiullillg the electrodes in zones of the cu"' ",i"g member with a lower porosity than non-zone areas of the ..u,.' ",i"g member. Within the zones are pockets of semi-trapped t:lel,II uly~;~, solution that increase the size of the electrode.
Yet another object of the invention is to provide an ablation apparatus that includes a flexible circuit.
Still a further object of the invention is to provide an ablation apparatus that includes an electrode positioned between first and second wos6/00042 2l 939~ r~ .s,. 12 fluid conduits that surround an ~ ydllddLlt: member housing an ele~ llulytk fluid.
Another object of the invention is to provide an ablation apparatus that includes a plurality of electrodes each with an insulator surrounding a portion of the electrode to provide for the selectable distribution of RF
energy to a desired surface.
Yet another object of the invention is to provide an ablation apparatus that provides selectable deiivery of RF energy to a tissue site and includes a feedback device in response to a detected ~ hdld~ tc:lialiu of the tissue site.
Still a further object of the invention is to provide an ablation apparatus that evenly distributes energy to the endometrium and includes a feedback device to monitor illl,~ ddll~ and temperature at the endo" ,~,t, ium.
Another object of the invention is to provide an ablation apparatus that includes a feedback device in response to a detected ~ halaul~lial;~. of the ~:, n~u~ b ium as well as one or more ultrasound transducers.
Another object of the invention is to provide an ablation apparatus that includes a feedback device for the controlled and selectable delivery of RF energy to the t:"du" ~ ~ ium where the il I l~e.6"~ e or a 1:" ".~ e profile of the endometrium is monitored.
A further object of the invention is to provide an ablation apparatus with a feedback device for the selectable delivery of RF energy where the apparatus includes electrodes with insulators that are fommed on a portion of each electrode for the even delivery of RF energy to a selected tissue site.
Still a further object of the invention is to provide an ablation apparatus that releases heated electrolytic solution to the endo,,,c:L,ium selectively distributes energy to the endometrium and includes a feedback device to monitor i" ".edanc e and temperature at the endu" le:ldum.

wo s6/00042 2 1 9 3 q 6 4 P~

Still a further object of the invention is to provide an ablation apparatus that includes a feedback device in response to a detected 1,1 ,a, d.,l~ri~tk, of the endometrium and the feedback provides a controlled delivery of RF energy to the endu",~l~iu",.
Another object of the invention is to provide an ablation apparatus including a cu"rur",i"g member made of a foam type substance.
A further object of the invention is to provide an ablation apparatus with a feedback device for the controlled delivery of RF energy, and the apparatus inciudes a cu, If ul " ~i"y member made of a foam type substance.
1û Still a further object of the invention is to provide an ablation apparatus that includes a "~ U~JolUUs ",e"~l"d"e.
Still a further object of the invention is to provide an ablation apparatus with a feedback for the controlled delivery of RF energy where the apparatus includes a microporous ",er"b,alle.
Still a further object of the invention is to provide an ablation apparatus that positions electrodes with insulators between two foam structures to provide for the selectable distribution of RF energy to a desired tissue site.
Yet another object of the invention is to provide an ablation apparatus that includes a printed circuit.
Still a further object of the invention is to provide an ablation apparatus that includes a printed circuit which monitors ill~,u~:dàll._e, temperature, circuit continuity, and is capable of multiplexing.
Yet another object of the invention is to provide an ablation apparatus with an ~,~pd"ddl,le member, such as a balloon, which houses an electrolytic solution that selectively flows out of an interior of the balloon and is delivered to a desired tissue site.
These and other objects are achieved with an ablation apparatus for ablating an inner layer in an organ or a lumen of the body. The ablation apparatus includes an l:Apdl ,dabl~ member having an interior section for wo96/00042 ~ 1 q 3964 ~ s~

housing an electrolytic solution a ..u,,lv,,,,i,,g member made of a material capable of SUb~ dllli.. 'y co"~n"i"g to a portion of the inner layer of the organ the, u"ru""i"y member delivering the electrolytic solution housed within the t:,~,Udl lI.Idble member to the inner layer of the organ one or more electrodes positioned in or on the u ullrulll,i"g member for delivering RF
energy to the inner layer of the organ an electrical connector device cu""euLi"9 the one or more electrodes to an RF energy source and an lv'~lti solution delivery tube for delivering the electrolytic solution from the ele- Iluly-;~ solution source to the ~A,~JdllddL~Ie member.
The apparatus may also include a feedback device which monitors a ul Idl dU~ ti~. of the inner layer and in response controls the delivery of RF energy to the one or more electrodes. The one or more electrodes may be positioned in or on the u ul lful l "i, lg member for delivering RF energy tothe inner layer of the organ eacil electrode including an insulator fommed on a surface of the electrode. The cw, " ,i"g member may also include non-zone areas with a first porosity rate for delivering ~l~u b ulytiu solution to the inner layer and zone areas for housing an electrode and ele. I,ulyti .
solution the zone areas having a second porosity rate that is less than the first porosity rate such that the eleul,~,lyt;~ solution passes through the zone areas at a slower rate than through the non-zone areas. The apparatus may also include a ",~",L,d"e positioned between the t:~.,UdllddL/Ie member and the l u,,,u,,,,i,,g member the Ill~..llbldll~: adapted to receive the electrolytic solution from the t:,~,Udl IddlJle member and deliver the electrolytic solution to the ~ o,,'v,,,,i,,g member.
The ~Luallddblt: member may include a plurality of apertures through which the electrolytic solution flows from the t~.,Udl Iddble member.
The e~L,vdllddLlt member may also be formed of a nonporous material.
The t:A,UdllddlJItl member may be positioned within the co" ",i"g member. The t:,wanddule member may be expanded Ill~ hdll' 'Iy and Wo96/00042 2 1 93q64 P~ 2 may be formed of a nonporous material. The cu, ,ru" "i"y member may be formed of a foam or an insulating material.
The uul,fullllillg member may be made of an open cell material.
The one or more electrodes may be n l 1";, ' -' The one or more cicuL~ udcs may form a flexible circuit. The one or more electrodes may fomm a printed circuit that is multiplexed. The printed circuit may include a plurality of segments. The electrodes may be positioned on a support member.
The feedback device may monitorthe il"! edd"~,e or tc,, Ir ' ~re of the inner layer at a p'ortion of the inner layer. The feedback device can include a controller and/or a multiplexer.
Inonee,,,Lodi,,,c,,loftheinvention,theablationapparatusincludes an C:~pdl ,.idLle member, made of a material with a porous exterior surface.
A heated clc~llul~lti., solution is housed in an interior of the e~pdllddLIc member and is released through the porous exterior surface. A cu, If ul " ,i"y member, with a conductive surface, and a back side in a surrounding r. ' " 1 ,hi,u to the eA~,dndable member, is made of a material that provides substantial confommity between the conductive surface and the inner layer of the organ or lumen. Heated electrolytic solution is received from the interior of the C,~,udl IddLllC member, and delivered through the fluid conduit to the inner layer. A plurality of electrodes are positioned between the expd"ddLle member and the fluid conduit. An RF power source is coupled to the plurality of electrodes. Also included is a device for heating the electrolytic solution to a selected temperature.
The cu~ ~fu~ g member, also called a fluid conduit, is made of an open cell material. The zone areas have less open cells than the non-zone areas. Electrolytic solution in the zones, and the I ' ' electrodes, effectively fomm larger electrodes. Two pieces of open cell foam can be sealed together to fonm the co"'u ",i"g member, with one or more electrodes positioned between the two pieces. Sealing of the two pieces ~ wos6/00042 2 1 9 39~4 P~

of open cell foam can be in the non-zone areas. Alb~ cly the two pieces can sealed in the zone areas and around the periphery of the u o~ ~rul l l li, ,9 member. A groundpad can be attached to an exterior surface ~ of a patient.
The ablation apparatus can also include an electrolytic solution source and a fluid delivery device for delivering the electrolytic solution from the electrolytic solution source to the interior of the eA~Jdllddule member. A device for heating the electrolytic solution can be ~.so~
with the electrolytic solution source. In this t:" Ibo.li, "~, IL heated ele~ LI, l~ 'k solution is introduced into the interior of the t~Audll.ldbi~ member.
Allelll icly the device for heating the electrolytic solution can be positioned in the interior of the ~:Apdnddi le member. ~ , 'Iy a feedback device can be included that is responsive to a detected chd~d~ ialib of the inner layer and provides a controlled delivery of RF
energy to the plurality of electrodes.
In an altemate e"lLJu.li",c:,lL the .u~'u~llling member is formed of a first and a second fluid conduit surrounding the e:Auandaule member.
According to this e" ,bo,ii~ "~:, IL the first fluid conduit surrounds the exterior of the ~A~dl~dable: member. The first fluid conduit provides delivery of electrolytic solution from the cApanddLle member. A second fluid conduit surrounds the first fluid conduit. The second conduit is made of a material that provides substantial confom1ity between the conductive suriace and a shape of the inner layer of the organ. The second fluid conduit delivers electrolytic solution from the first nuid conduit to the inner layer. A plurality of ~lauL,udes are positioned between the first and second conduits. By poaiLiullillg the electrodes between the first and second fluid conduits energy delivery from the electrodes to the inner layer is 5Plpct~hlp It is selPct~hlp in that the energy can be distributed evenly over the target surface and energy delivery can be variable dept:ndi.,g on the condition of the selected tissue site.
2 1 93964 i~ s 112 ~

The electrodes can be positioned on a support member.
Additionally, the electrodes can fomm a flexible circuit made of a plurality of segments. The electrodes can be a printed circuit, or a plurality of individual electrodes. The t:~,lJdl IddL/Itl member can be expanded within the interior of a selected organ l l le.. hdl li~ , or by introducing a fluid, such as an electrolytic solution, into its interior. In one t:~nbudillltllll, the ~xpancldLI~ member is a balloon.
The first fluid conduit can be made of a foam. The second fluid conduit is made of a material that provides substantial confommity between the conductive surface and the inner layer of the organ being ablated. The second fluid conduit is preferably made of a foam.
In one ,:",I"~di",~"L, the second fluid conduit has non-zone sections with a second rate of porosity for delivering electrolytic solution to the innerlayer. The second fluid conduit also includes zones for housing the electrodes and electrolytic solution. The zones, with the electrodes, have a second porosity rate that is less than the first porosity rate, and ele.,l,.,lytic solution passes through the zone at a slower rate than electrolytic solution passing through non-zone areas of the co"' ",;"9 member. The second fluid conduit has an RF conductive surface and a 2û back side in surrounding r.' ' lahi,l~ to the exterior surface of the~:A,Udl ,dable member. An RF power source is coupled to the electrode.
In another ~,ubo.li,n~"l of the invention, the ablation apparatus includes an c:~pa, Iddbl_ member, made of a material with a porous exterior surface. A heated electrolytic solution is housed in an interior of the ~ anddule member and is released through the porous exterior surface.
A fluid conduit, with a conductive surface, and a back side in a sunrounding I ~IdliUl lahip to the t~ dl Idal)le member, is made of a material that providessubstantial confommity between the conductive surface and the inner layer of the organ or lumen. Heated electrolytic solution is received from the interior of the ~ydnddL It: member, and delivered through the fluid conduit ~ wos6/00042 21~39~4 r .,~s~ 12 to the inner layer. A plurality of electrodes are positioned between the ~A,Udl ~ddUIt~ member and the fluid conduit. An RF power source is coupled to the plurality of electrodes. Also included is a device for heating the ~ electrolytic solution to a selected temperature.
The fluid conduit can be made of an open cell material. The zone areas have less open cells than the non-zone areas. Electrolytic solution in the zones, and the ~u~ d electrodes, effectively form larger electrodes. Two pieces of open cell foam can be sealed together to form the co,lfu""i"g member, with one or more electrodes positioned between 1 û the two pieces. Sealing of the two pieces of open cell foam can be in the non-zone areas. AlL~ .ti~_'y, the two pieces can sealed in the zone areas, and around the periphery of the .,u, If ul l l lil Ig member. A groundpadcan be attached to an exterior surface of a patient.
The ablation apparatus can also include an electrolytic solution source, and a fluid delivery device for delivering the t~ .,bu'yti_ solution from the electrolytic solution source to the interior of the tApa"ddL,le member. A device for heating the ele,,L, ~ ti~. solution can be ;~ ' ' withtheelectrolyticsolutionsource. Inthise,,luo.li,,,~,,L,heatedelectrolytic solution is introduced into the interior of the ~A~dl IddUI~ member.
AIL~Il ' I_ly, the device for heating the electrolytic solution can be positioned in the interior of the eA,ual Iddl-le member.
Optionally, a feedback device can be included that is ~ ,uol~_iYe to a detected ..hdlduL~liaLk. of the inner layer and provides a controlled delivery of RF energy to the plurality of el~,lludes. In response to the 2~ detected ulldlduL~ a, the ablation device then provides a controlled delivery of RF energy to the electrodes or segments of the circuit. Various detected l,hdldul~ Liu!~ include, ill,,ueddll-,e of a segment of the inner layer, and a temperature profile of the inner layer at a segment. The feedback device can include a controller and a multiplexer. With the W096100042 2 ~ 93~ 6~ P~ ,. 12 multiplexer, individual electrodes or flexible circuit segments are rr~ y~
In one e",bu iill~e"l, the eA,udn idbl~ member is a balloon, and the first and second conduits are made of an open cell foam. Additionally, the foam material of the .. u, ~ful " ,i"g member is particularly pliable and suitable for cuufull "i"g to the inner layer, and achieves an effective ablation of all or a part of the inner layer even when the inner layer has a very irregular surface.
The feedback device may be used to detect i",~.e 6"-,e or a temperature profile of the inner layer at the electrodes or a segment of the circuit. The amount of delivered RF energy may be adjusted according to the detected i" l~ueddl n~ or temperature profile. Additionally included in the uu, ~ful l l lil Iy member is one or more ultrasound transducers.
The cor,fu,,,,i,,y member provides a conductive surface that conforms to surfaces that have irregular shapes and with the feedback device, a controlled delivery of RF energy is deiivered to the endometrium.
The cu",bi, ns of partially insulated electrodes positioned between the two fluid conduits provides for a 5~1Prt~hlP, even, non-direct delivery of RF
energy. Thus, RF energy can be effectively delivered to irregular surfaces.
The feedback device provides controlled delivery of RF energy based on detected ulldlduleli~lk~ of the el, iu",~,',ium. The ablation apparatus is multiplexed between different electrodes or circuit segments of the flexible circuit.
The flow rate of ~:lel_ll u'~tk, solution leaving the balloon, including but not limited to saline solution, may be adjusted and depends on the pressure applied by the electrolytic solution to the balloon, typically caused by increasing or dewed ,illy the amount of electrolytic solution in the balloon. The ",e"lu,d"e is n~k~uuo~uus and the cu"ru""i"g member, which typically is a layer of a foam type material, both provide a controlled 3û flow of electrolytic solution to the inner wall of the body organ. Additionally, wo 96/00042 2 1 q 3 q 6 4 P~."J~ 12 the foam material of the cul~fullll;,ly member is particularly pliable and suitable for .,u, ~ful " ,i"g to the inner wall, and achieves an effective ablation of all or a part of the inner wall even when it has a very irregular surface.
~ The ablation apparatus of the invention is suitable for abiating a 5variety of surfaces of body organs including but not limited to the endu~ ldum of the uterus.

Figure 1(a) is a perspective view of an ablation apparatus of the invention housed in an introducer sleeve and includes viewing optics.
1ûFigure 1(b) is a p~a,ueu~ c view of an ablation apparatus of the invention in a non-deployed position as the introducer sleeve is withdrawn.
Figure 1(c) is a p~la,ueuL,l~ view of an ablation apparatus of the invention in a deployed position.
Figure 2 is a pe,:.,ue~ view of a handle ' with the 15ablation apparatus of the invention.
Figure 3 is a l~,ulC:~el ":c block diagram of the invention showing the light, RF, ultrasound and electrolytic sources and theim. ' " I:.h;,u:, to the ~,Udl l idLI~ member.
Figure 4 is a flow chart listing the operation of the ablation apparatus 2ûof the invention.
Figure 5(a) is a cross-sectional view of the ablation apparatus of the invention, illustrating the zone and non-zone sections of the ..u"' ",i"g member.
Figure 5(b) is a cross-sectional view of the ablation apparatus of the 25invention with an ~.,Odl l idUIe device surrounded by a .,O"ru" "i"g member.
Figure 5(c) is a perspective view of the ablative effect of t~ uues positioned on a balloon without an insulator.
Figure 5(d) is a cross-sectional view of the ablation apparatus of the invention with a porous Ille:lllbldl,e positioned between one side of an W096/00042 2 1 93964 1~l,1 sc ~:i2 ~,ud"dabl~ device and a uc,"ru""i"y foam structure that is positioned adjacent to an inner layer of an organ.
Figure 5(e) is a cross-section view of an ablation apparatus of the invention and includes a core lumen that houses illumination and viewing optical fibers, fluid conduits and sensor and electronic cabling.
Figure 6(a) is a cross-sectional view of the collfullllilly member made of an open cell foam material. Two pieces of foam are sealed to create a zone, or pocket, of electrolytic solution around an RF electrode.
Figure 6(b) is a cross-sectional view of the cullfullllillg member made of an open cell foam material. Two pieces of foam are sealed at the electrode, creating a zone that comprises an RF electrode and electrolytic solution which remains in the zone a longer time than the electrolytic solution in non-zone regions of the ~,ullful ",i"g member.
Figure 6(c) is a cross-sectional view of two layers of an open cell foam that are jointed with an RF electrode disposed between the two layers, fomming a zone. The zone has a lower porosity rate than non-zone areas. Included in the zûne is electrolytic solution, which together with the RF electrode create a larger electrode.
Figure 7 is a graph and table of measured lt:lll,ul ' Ires of zone and adjacent non-zone sections of the ablation apparatus illustrated in Figure 6(a) Figure 8 is a graph and table of measured temperatures of zone and adjacent non-zone sections of the ablation apparatus illustrated in Figure 6(b).
Figure 9 is a cross-sectional view of a multiplicity of zones in the cu, If ul " ,i"g member.
Figure 10 is a perspective view of a plurality of electrodes that comprise a flexible circuit in the interior of the CO~I,ul",i"y member.
Figure 11 is a perspective view of the ablation apparatus of the invention, with the flexible circuit positioned adjacent to an interior side of Wo96/00042 2 1 93q64 ~ 12 the cu"r~""i"9 member. In this figure, the insulator has been removed for ease of viewing the flexible circuit.
Figure 12 is a cross-section view of the ablation apparatus of the ~ invention, with the flexible or printed circuit positioned adjacent to an interior side of the .. u, IFul " ,i"y member, a plurality of conductive filaments being disposed in the cu"ru""i,lg member.
Figure 13 is a perspective view of one of the segments of the flexible circuit shown in Figure 9.
Figure 14 is a cross-sectional view of the introducer sheath ---- ' ' with the ~,udllddble member of the invention. Housed in the introducer sheath are viewing and illumination fibers, a tension wire, an RF
cabie, an ultrasound cable and an electrolytic solution tube.
Figure 15 is a cross-sectional diagram illustrating the relative puaitiul li~ I,u, of the flexible circuit of the invention in the uterus.
Figure 16 is a block diagram of an ablation apparatus of the invention that includes a controller and multiplexer.
Figure 17 is a block diagram of one ~IllL,udi,,lt:llL of a system for ,ul uue~ il lg outputs from the temperature sensors and ultrasound transducers.

2û DET~Il Fn DESCRIPTION OF Tl IF Pr~ r~ r~ OD~ 'TS
An ablation apparatus 10 of the invention is illustrated in Figures 1(a), 1(b) and 1(c) and includes an ~,~pa~"~dLle member 12 that is introduced into a desired body organ or lumen through an introducer sleeve 14 which can be attached to a handpiece such as the handpiece 16 illustrated in Figure 2. In one e,ul,udi,,,~,,L of the invention, t:~,udllddLlt:member 12 is a balloon, but it will be d,U,UI~ ' ' ' that other devices capable of being in confined non-deployed states, during their introduction into the desired body organ or lumen, and thereafter expanded to deployed states, can be utilized.

WO96/00042 21 9 3 9 6 ~ F~ 12 CA~JdllddLJle! member 12 is rolled orfolded around a core lumen 15 which can contain optics, fluid paths, sensor and electronic cabling. It can be attached to a ratchet hinge 18 which imparts movement of expdllLldble member12whenitisinabodyorganorlumen. ALldLiulld,u~udld~ 1ûcan generally be rolled or folded around a helical type of elongated stnucture in order to provide a wringing type of motion to assist in its removal from the body organ or lumen.
[Xpdl IddlJle member 12 is introduced through introducer sleeve 14 in a folded, or non-distended configuration. Introducer sleeve 14 can be of different cross-sectional sizes. In one ~ bOdi,,,e,,L, it is small enough to be introduced into the cervix under local dl ,ae:,Lhe:,id, and can be on the order of about 5 mm or less in diameter.
Fommed spring wires can be included in ~A,udl ,ddL,le member 12 to assist in opening it to the deployed position. Positioned on core lumen 15 are a variety of actuators which provide physician control of ablation apparatus 10, as more fully described hereafter. The actuators can be rocker switches, slider switches and the like, as are well known to those skilled in the art. Ablation apparatus 10 is suffficiently opaque that it is visible under ultrasound.
Introducer sleeve 14 is introduced into the desired organ or body lumen, as shown in Figure 1(a), with t:A,udllddL~ member 12 in a non-deployed configuration. Following introduction, introducer sleeve 14 is withdrawn and can be retracted into core lumen 15. Introducer sleeve 14 can be of conventional design, such as an introducing catheter, well known to those skilled in the art. Ex~.d, IddLJl~ member 12 can be swept from side to side, which movement can be imparted by hinge 18. Hinge 18 also provides for easy introduction of ablation apparatus 10 through the vagina, and into the cervix and uterus.
Generally, ablation apparatus 10 can be a ",o"u~ uldr or bipolar electrode system. It is capable of expanding so that _A?anddL/II: member wo 96/00042 2 ~ 9 3 q ~ 4 ~ 12 12 becomes expanded within a selected body organ or lumen, and RF
energy is delivered to an inner lining of the organ or lumen. RF and themmal energy are passed through the inner lining or surface for a time ~ period selected that is sufficient to achieve a desired level of ablation. This varies dependi,lg on the body organ or lumen. In a ",onoi ola~ mode RF
current flows through body tissue from a return electrode, in the fomm of a conductive pad, applied to the patient's outer skin. Maximum heating occurs where the current density is the greatest.
In one e:lllbOdi~ lll of the invention, the body organ is the uterus, and the lining is the e"du" ,~1, ium. It will be d,UlJI I ' ' that the present invention is not iimited to the endu,,,c:t,i.lm of the uterus and that other organs, including but not limited to the general field of gy, ,ec,ulugy, can also be treated with the invention.
Electric current flowing through the enclo",~t,ium causes heating due to resistance of the tissue. Cndu" ,.:1, idl ablation can be accu"" ';~.hecias a relatively simple medical procedure with local a"e~ll,esid.
Referring now to Figures 2 and 3, a rocker switch 60 operates the rotation and viewing of viewing optics 46, as well as the nlu~ lll of the flexible scope. A slider switch 62 controls movement of introducer sleeve 14. Rockerswitch 64 is -~u. ;~ cl with tension wire 48. It is activated to cause hinge 18 to pivot and impart mtl.,l Idl lil~dl 11 IU U. 11~111 to ~ApanLidiJIe member 12. Rocker switch 66 is operated by the physician to control the delivery, and in certain instances, the amount of RF energy from a suitable RF energy source 68. Rocker switch 70 controls the flow of el~:~.l,ulytk, solution to and from ~:IXIJdllddiJl~: member 12 to an electrolytic solution source 72. Finally, a switch 74 is - ' ' with ultrasound transducers 58. It will be app,t:ui_'~d that a video camera system can be r~
with handle 16.
Further with regard to Figure 3, an optical system 76 can include a light source, r~~~ ~ ' ' illumination and imaging fibers 44, which can be wos6/00042 2 1 q3q 64 P~ ' 12 ~

in the fomm of a flexible ~:ndu~cùpe, and ~o~ d switch 60 that operates the rotation and viewing of viewing optics 46. Optical system 76 can also include an output going to a VCR, camera, and the like, and a feedback output to RF source 68 and a controller 78. RF energy source 68 can i,,uu,,uo, a controller, as well as both temperature and i,,,,ueda,,~,e n ,ul, ' i"g devices.
Also included may be an electrolytic solution source 72 with a pump/pressure flow control device 80, as is well known to those skilled in the art. Also included may be a heating device 82, for heating the electrolytic solution, is ,.~su. ;.~l~d with ~le~l,ulytk, solution source 72, or it can be positioried in ~ ,uanddule member 12. Suitable heating devices inciude but are not limited to coils, bipolar electrodes, catalysts, and other devices, as are well known to those skilled in the art. An ultrasound source 84 may also be coupled to one or more ultrasound transducers 58 that are positioned in or on c~l ,ful l l lil Iy member 20. Ultrasound transducers 58 canbe positioned apart from cw If ul ,, ,i"g member 20. An output is ass - ' with ultrasound source 84 and RF energy source 68.
Each ultrasound transducer 58 can include a p;~,.,.ole~ I j., crystal mounted on a backing material. An ultrasound lens, fabricated on an electrically insuiating material, is mounted between the pie:~uc:leull iu crystal and cullfullllilly member 20. The p; ~ k Idu crystal is connected by electrical leads 54 to ultrasound power source 86. Each ultrasound transducer58transmitsultrasoundenergythroughcu,,,u,,,,i,,ymember20 into adjacent tissue. Ultrasound transducers 58 can be in the fomm of an imaging probe such as Model 21362, manufactured and sold by Hewlett Packard Company, Palo Alto, California.
Figure 4 is a flow chart illustrating one ernuu,li" ,u"L of the operation of ablation apparatus 10. In this ~:" ,bodi" ~t:"L, ablation apparatus 10 is first introduced into the uterus under local allae~ C_;... Introducer sleeve 14 is then withdrawn, and uAp.lllddule member 12 is expanded, either W096/00042 2 l 939 64 r~ 2 rl~echa~ , with the introduction of a fluid or gaseous expanding medium, such as an electrolytic solution, or a uu~ ~ Ibi,, ' 1 of both. For thispurpose fommed spring wires can be used alone or in co"lLi,ldtiùn with a fluid to expand ~,~panddule member 12. Electrolytic solution is introduoed into ex udnddule member 12, causing it to become distended and be self-retained in the uterus.
Electrolytic solution in expd"daL,le member 12 is heated to a pre-selected l~ ,ut~ re, which can be modified and adjusted as necessary.
For example, electrolytic solution can be heated and "...;.,tained at a 1û temperature between about 60 to 90 degrees C. It can be initialiy introduced into e~pdl n~dLIe member 12 at the higher I~l l Ir ~ re. or it can be heated to the higher temperature in ~:x~dl1cldult: member 12. By providing a heated electrolytic solution, there is a reduction in the amount of time needed to complete a ~dti:~rduIol y ablation.
The diagnostic phase then begins. This is achieved through a variety of lln:ulldlliallla, including but not limited to, (i) visll ' " n, (ii)measuring i" I,Ut:ddl ,ce to detemmine the electrical conductivity between the endu, "~t, ium and ablation device 10 and (iii) the use of ultrasound imaging to establish a base line for the tissue to be treated.
In the treatment phase, the ablation of the uterus can be conducted under feedback control. This enables ablation device 1 û to be positioned and retained in the utenus. Treatment can occur with minimal attention by the physician. Ablation apparatus 10 autu, lldti~.a Iy confomms to the interior of the uterus, provides a relatively even flow of heated ~le.,I,uly'k, solution to assist in the ablation, and a plurality of elt:cL,udes contained in zones, effectively create a flexible circuit. It can be multiplexed in order to treat the entire el1do,~llium or only a portion. Feedback can be included and is achieved by, (i) visualization, (ii) i"".,eddn..e, (iii) ultra-sound or (iv) It:" "", ~re measurement. The feedback l I l~. hal 1;~,. 1 I pemmits the tuming on and off of different electrodes of the flexible circuit in a desired ablative W096100042 21 93964 r ~ 2 pattern which can be sequential from one elecfrode to the next, or it can jump around different electrodes.
The amount of ablation can vary. However it is desirable to ablate about 2 to 3 mm, with d,U,U~ UA;II IdLely 1 mm of the myometrium. Ultrasound can be used to create a map of the interior of the uterus. This i, If u, ", ~;Jnis input to a controller. Individual electrodes are multiplexed and volumetrically controlled. If desired, the area of ablation can be sul,aLd, ILi. :!y the same for each ablation event.
Even though there are folds and crevices in the endu,,,_~,i.lm, the entire endometrium can be treated and selectively ablated. The selective ablation may be the even pen~l,d1un of RF energy to the entire eudo",t:I,ium a porfion of it or applying differenf levels of RF energy to different endometrium sites, depending on the condition of the el)do",~ m. The depth of RF and thenmal energy pe~ in the endo",~.,i"m is controlled and celP~hlp A second diagnostic phase may be included affer the treatment is complefed. This provides an indication of ablation treatment success, and whether or not a second phase of treatment to all or only a porfion of the uterus, now or at some later time, should be conducfed. The second diagnostic phase is a. . w,,u5~.hed through (i) visll " (ii) measuring illlueJdlll t:, (iii) ultrasound or (iv) temperature measurement.
One t:",bu-l;",t:r,l of ablation apparatus 10 is illustrated in Figure 5(a). EAudlldaLle member 12 is made of a material that can be an insulator. For purposes of this disclosure, an insulator is a banrier to themmal or electrical energy flow. In this ~",bodi",t~"L t:A~Jdllddble member 12 is substantially sunrounded by a co"ru""i"g member 20 which is also called a fluid conduit. Confomming member 2û receives electrolyfic solution from l:A~JdllddLJlt: member 12 heated or not heated, through a pluralify of apertures 22 fommed in t:xpd".laLlt: member 12, and passes it to cu"Fu"";"gmember20. Expa",ldL,l~member12ismadeofamaterialthat ~ w0~6/00042 2 l 93~ 64 r~ 2 permits controlled delivery of the electrolytic solution through one or more distribution ports 21, and can be made of a microporous material that does not include distinct apertures.
~ In one e,I,LJoLne"l, ablation apparatus 10 confomms tightly with the interior of the uterus so that all, or almost all, of the elldor"~,'d.lm is in contact with a conductive surface 24 of .,u"'~ ",i"g member 20.
Conforming member 20 is ftted into the entire uterus and c,~,uanddLle member 12 does not have to be moved about the uterus to complete the treatment. Alternatively, ablation apparatus 10 may not entirely fill the utenus, and ablation apparatus 10 is then moved about the uterus in order to ablate all of the endu,,,cL,i~lm, or those sections where ablation is desired. Selected portions of the endu,,,cl,ium may not be ablated, such as those portions close to the fallopian tubes.
Confomming member 20 is made of a material that sul"Ld, " 'Iy confomms to the surface of the endo,,,cL,i-lm. This provides better confommity than the mere use of c~,udndable member 12, and the delivery of treatment energy to the e udu, ~ l~h ium is enhanced.
While e~,ud"daL)le member 12, with a single interior section 26, is preferred, it will be d,u,ul c~,idLcd that e,~l-d"ddLJIc member 12 can be made 2û of different ~,U~ vsiLiulls or materials, with one or more open or closed cells or chambers. The plurality of such cells or chambers can be co,,,y,cssed or conf gured in a small diameter for insertion, and are then expanded after insertion to establish the desired electrical contact with the targeted surface of the el)dc." ,cL, ium.
Confomming member 20 is made of a material that suitably confomms to a surface to be ablated, and can have a thickness in the range of about O.O1 to 2.0 cm. Confommins member 20 can be made of a foam type material. Suitable materials include but are not limited to, knitted polyester, continuous filament polyester, polyester-cellulose, rayon, polyamide, polyurethane, polyethylene, and the like. Suitable collllllcluidl foams W096/00042 2 1 93964 1~".,~ ~. 12 ~

include, (i) Opcell, available from Sentinel Products Corp., Hyannis, Massachusetts and (ii) UltraSorb, HT 4201 or HT 4644MD from Wilshire CUIIIdlllilldLioll Control, Carlsbad, California. Conforming member20 has .,haldl,le:li.li~,s that make it particularly moldable and culllvlllldlJI~ to irregular surfaces. In one u" ~bodi" ,t:, IL, Cul Irw I l lil Iy member 20 is made of a an open cell foam, or alternativeiy it can be a II,e""opld:,li,, film such as polyurethane, low density polyethylene, or may be a silicone rubber.
Additionally",o~ru~"i"g member 20 can be capable of extruding conductive materials from cu~rul",i"g member 20 itself. Conforming member 20 can be implanted with conductive ions, and conductive surface 24 can be coated with a material that improves its conductivity.
In an alternate t:",bo ii~e:~l illustrated in Figure 5(b), ex,udll idble member 12 is made of a material that is an insulator to RF energy. In this u"luudi",e"l, expdll idblt: member 12 is substantially surrounded by a first fluid conduit 25, which in turn is surrounded by a second fluid conduit 27, the first and second fluid conduits serving as a cu"ru""i"g member. First fluid conduit receives electrolytic solution from u,~,uall iable member 12, through a plurality of apertures 29 formed in t:,~,uancidulu member 12, and passes it to first fluid conduit. E-xpallddult: member 12 is made of a 2û material that pemmits controlled deiivery of the electrolytic solution, and can be made of a microporous material that does not include distinct apertures.
First fluid conduit 25 can be a Ille:llluldlle, such as a ",i~,,upu,uus ",e"lu,d"e, made of Mylar, expanded PFT such as Gortex available from Gore Company, and the like. As a Illt:lllUldlle, first fluid conduit 25 is relatively strong, and sufficiently heat resistant for the amount of themmal energy that is supplied to the endometrium. As a l"~,.uu-d"e, first fluid conduit 25 applies pressure, relative to the electrolytic solution, and thus assists in controlling its flow rate. First fluid conduit 25 can also be made of a foam.
First fluid conduit 25 can be a heat sealed plenum, to distribute wo 96/00042 2 l 9 3 q 6 4 F~,l/u~.,~.'l 112 elt!~L".l~ti~ solution, if second fluid conduit 27 is made of a foam type of material. It is not needed if second fluid conduit is a perforated film. In thise,,,l,odi,,,c~ , ablation apparatus 10 confomms tightly with the interior of the~ uterus so that all, or almost all, of the t:ndc",t:l,ium is in contact with a conductive surface 31 of second fluid conduit. In this case second fluid conduit 27 is fitted into the entire uterus and expd, nidLJlt: member 1 Z does not have to be moved about the uterus to complete the treatment.
Alternatively, ablation apparatus 1û may not entirely fill the uterus and ablation apparatus 10 is then moved about the utenus in order to ablate all of the ~l nlul I It:tl ium, or those sections where ablation is desired.
The second fluid conduit 27 acts as a cullfullllilly member by substantially co"ru" "i"y to the surface of the endometrium. This provides better conformity than the mere use of e:Apallddblt: member 12, and the delivery of treatment energy to the t:"du" ,~ :t, ium is enhanced.
Interior section 33 contains an ele.,l, ulytk, solution, such as saline.
The amount of electrolytic fluid in interior section 33 is one of the factors for ~Ldbl;~'lilly the flow rate of electrolytic solution out of interior section 33.EA~udllddL le member 12 can become more pressurized by increasing the amount of electrolytic solution. As ele,,L,uly'i~, fluid enters ~A~Jdlldd~
member 12, the pressure within interior section 33 increases. This increases the flow rate of el~LL,ulytic solution out of apertures 29. A
reduction in pressure will cullt:a~ulldillyly reduce the flow rate. The LUIII illdLiun of second fluid conduit 27 and the u,," ", of the ,Llulyti-. solution through second fluid conduit 27 provides for effective delivery of RF energy to endo",t:t,ium surface.
Positioned between the first and second fluid conduits 25 and 27 is a plurality of electrodes that " ' /cly can be in the form of a flexible circuit, both denoted as 37, described in greater detail further in this ,. An insulator 39, such as nylon, polyamide, latex, Teflon and the like, is partially deposited on electrodes 37 so that a back side of W096/00042 21 93964 P~ 12 ~

second fluid conduit 27 is insulated from the direct delivery of RF energy from that adjacent electrode. Insulator 39 prevents RF energy from electrodes 37 to pass directly from electrodes 37 through second fluid conduit 27. Instead RF energy is applied indirectly to the el,dc",.~ ium, causing a thenmal affect in the tissue. RF energy from electrodes 37 arcs out through first fluid conduit 25 and then through second fluid conduit 27.
E~,udll Idblt: member 12 serves as a second insulator.
Figure 5(c) illustrates ihe case where a plurality of electrodes 41 are positioned on an exterior surface of e~JdllddLile member 12. There is direct energy delivery to the tissue. This results in an uneven pt:"~t, of energy to the endometnum. There is too much ablation for those areas of the endo",t:l,i.,m adjacent to an electrode 41. The problem is compounded as the number of electrodes 41 adjacent to the endometrium is increased. As previously mentioned it has been .,i~._o~_.c:., that insulator 39 provides an even pen~t~dliùll of ablative energy.
As illustrated in Figure 5(d) second fluid conduit 27 can be a heat sealed plenum to distribute electrolytic solution if co,,fu,l,,i,l9 member is made of a foam type of material. It is not needed if cwlful",;"9 member is a perforated film. In this t:",L,o-,i",~"l ablation apparatus 10 conforms tightly with the interior of the uterus so that all, or almost all, of the endu",t:l,i.,m is in contact with a conductive surface 31 of second fluid conduit 25. In this case, ex,uan.,dl,le member 12 does not have to be moved about the uterus to complete the treatment. All~ cly, ablation apparatus 10 may not entirely fill the uterus and ablation apparatus 10 is then moved about the uterus in order to ablate all of the endometrium, or those sections where ablation is desired.
Vvhile a balloon with a single interior section 33, is the preferred ldl ,ddl,le member, it will be auul~ that the e~l.d, IddLl~ member can be made of different co", ,:, or mater,als with one or more open or closed cells or chambers. The plurality of such cells or chambers can W0 96/00042 2 1 9 3 9 6 ~ F~ e~ e -l~

be cu""J,t:~sed or configured in a small diameterfor insertion and are then expanded after insertion to establish the desired electrical contact with the desired surface of the endu, "~L, ium.
~ Interior section 33 contains a ~leullulyl;~, solution, such as saline.
The amount of electrolytic fluid in interior section 33 is one of the factors for e~ldL l;~.hillg the flow rate of eleut",l~ti., solution out of interior section 33.
ExpdlldàL.le member 12 can become more pressurized by increasing the amount of electrolytic solution. As electrolytic fluid enters ex,l)à"ddble member 12, the pressure within interior section 33 increases. This increases the flow rate of eiectrolytic solution out of apertures 29. A
reduction in pressure will coll~:a~Jùlnlillyly reduce the flow rate.
First fluid conduit 25 is made of a material that suitably confomms to a surface 35 that is to be ablated and can have a thickness in the range of about 0.01 to 2.0 cm. First fluid conduit 25 can be made of a foam type material. Suitable materials include but are not limited to silicon reinforced natural gum nubber, neoprene, soft gum nubber, polyurethane, and the like.
First fluid conduit 25 has ul Idl dUIl~ li~ that make it particularly moldable and cu,,' IllaLJle to irregular surfaces. In one ~ boui,~ t, first fluid conduit 25 is made of a an open cell foam, or altematively it can be a ll ,t:", lu,Jla ,ti.; film such as polyurethane, low density polyethylene, or may be a silicone rubber. ~ y, first fluid conduit 25 can be capable of extruding conductive materials from first fluid conduit 25 itself. First fluid conduit 25 can be implanted with conductive ions, and conductive surface 31 can be coated with a matelial that improves its conductivity. The colllbi,ldLiul1 of first fluid conduit 25 and the:,, ' " , of the el~.. L,(,ly.i~, solution through first fluid conduit 25 provides for the effective delivery of RF energy to t:"dr " l~t~ ium surface 35.
Figure 5(e) illustrates another ~ bu.li,~e~lL of the invention with ~AI~d,,daLlle member 12 having a first side 43, and a second side 45, the second side including a plurality of apertures 29. In this t:"ll,oui",~:"l, the wos6/00042 21 93964 r~ 12 ~

ablative apparatus 10 is moved about the interior of the uterus 36 whcre the f rst side 43 of the device presses against the intenor surface 35 of the uterus.
Figures 6(a) - 6(c) illustrate that co~fv""i"g member 20 can be created by sealing two cu"Fu""i"g members 20(a) and 20(b) together. In Figure 6(a), co"ru""i"g members 20(a) and 20(b) are sealed together between individual electrodes 28. This creates a pocket or zone 30. Zone 30 has a iower porosity for the flow of electrolytic solution than non-zone sections 32, e.g., all other sections of cu~ ~ruu "i, ~y member 20 which do not include a zone 30 with an dS~O~- ' d electrode 28. The porosity of non-zone sections 32 is greater than the porosity of zones 30.
Electrolytic solution is released from interior 26 of ~ Jdll idLle member 12 and passes through cu,lrul",i"y member 20. The iirr~rt:"~ s in porosity is achieved in an open cell foam, with zones 30 having less open cells than non-zone sections 32. Electrolytic solution is retained in zones 30 longer than in non-zone sections 32 and its Lt~ re is elevated. The semi-trapped electrolytic solution in zones 30 combines with electrode 28 to create a larger electrode. The larger electrode produces RF and thermal energy to cu~ ~ful l l lil lg member 20, which is Ll dl laft~ d to tissue through conductive surface 24.
Electrolytic solution travels through zones 30 at a slow enough rate to create this larger electrode effect. The porosity of zones 30 is selected so that electrolytic solution remains in the respective zone 30 sufficiently long enough to become heated to an elevated temperature and produce the larger electrode effect.
In Figure 6(a), ~,u"ru" "i"g members 20(a) and 20(b) are sealed in non-zone areas 32 and along the p~dyll~ of 20(a) and 20(b). This creates a structure that, (i) conforms closely to the ~" io",~', ium or other organAumen structures, (ii) effectively introduces electrolytic solution to the desired tissue site and (iii) with the inclusion of zones 30 with lower w096/00042 2 1 939 64 r~ e Il porosity, electrolytic solution is elevated to a higher ll:lll,uel ~re. The result is a greater RF and themmal effect that is evenly applied to the tissue site such as the t~nd(,",_l,i.lm.
~ Figure 6(b) illustrates uuurullllilly members 2û(a) and 2û(b) sealed at electrode 28 to create zone 30, and not sealed at non-zone sections 32 except at the pe,i,uheri~s of c.",'~.",i"y members 20(a) and 20(b).
Figure 6(c) illustrates zone 30 filled with t:l~ullulyL~, solution which becomes heated to a desired elevated It:" ,,u~, ~re while it remains in zone 30.
As an exampl~ of ablation apparatus 12, a foam patch with zones 3û and non-zone sections 32, utiiized two pieces of UltraSorb foam which were sealed between 0.004 inch by 0.016 inch (SST) flat electrode wire with d~-,uluAillldtcly 80 Q/foot. About 1.0 inch of SST wire was exposed in the foam. Different foam thickness were used and included, (i) 1/16 inch by 1/8 inch, (ii) 1/8 inch by 1/16 inch and (iii) 1/16 inch by 1/16 inch. The foam size was about 1.0 inch by 1.0 inch. A return electrode, through a sheet of brass, was utilized. A 0.9~/0 saline solution was utilized and placed in a test bath. The plt:aodkt:d foam patch was laid inside the test bath.
The system was energized and temperature across the path was monitored. TemperatureT2,t:,u,~:a~:,,t~dthelt:,,,,ut, ' ~reinthezone,while temperatures T, and T3 It:,ul~ael.'~,d temperatures in adjacent non-zone sections 32.
The results are shown in Figures 7 and 8. Temperatures in zone 30 were higher than temperatures in adjacent non-zone sections 32. In Figure 7, 50 n was connected, and the i" ,,uedd, ,ue was about 85 Q In Figure 8, 50 Q was cu, " ,euLt:d, and the i" ,,uedd"ut: was about 90 Q
Interior 26 can contain heated ele,,l,ulylih solution, such as saline.
The amount of electrolytic fluid in interior 26 is one of the factors for ' I hi"g the flow rate of elc:ul~uly'i~. solution out of interior 26.
EA~Jdllddble member 12 can become more pressurized by increasing the W096100042 2 1 93q64 I~l,l '. 12 ~

amount of eiectrolytic solution. As electrolytic fluid enters e~JandaiJII:
member 12 the pressure within interior 26 increases. This increases the flow rate of electrolytic solution out of apertures 22. A reduction in pressure will ~ulluauul1d;llyly reduce the flow rate. Electrolytic solution is introduced into interior 26 through fluid distribution ports 21 fommed in for example core lumen 15 or it can be introduced through a separate fluid conduit.
Heated electrolytic solution can be delivered from ex~.a".ldi,le member 12 through uo~rull,,i,,y member 2û and is then delivered to the tissue to be ablated . Fluid flow can be continuous or non-continuous to the tissue site.
As shown in Figure 9 a flexible circuit 34 is made of individual electrodes 28 in zones 3û and positioned within co"Fu""i"g member20.
Figure 10 shows individual electrodes 28 with thermocouples that can be used and multiplexed in either of l~olluuuldl or bipolar schemes.
Referring again to Figure 9 electrodes 28 and zones 30 are capable of muitiplexing so that only certain electrodes 28 deliver RF and thermal energy at a particular time period. Zones 30 provide individual ablative coverage and delivery for the entire conductive surface 24. In this regard the plurality of zones 30 can provide ablative regions individually everywhere on conductive surFace 24.
The selectivity can be the even: r ~' " I of RF energy everywhere it is applied to the endometrium so that the same depth of en-lu",~l,i.lm is ablated or the amount of applied energy can be variable de~,al,di"g on the ulldlduluriali~s of the endometrium surface. In this instance certain sections of the l:"do"lt:l,ium will have more tissue ablated than other sections.
Each zone 30 connects to a separate feedwire 34 with all of the wires going to a ribbon connector 38. Feedwires 34 are insulated. Each electrode 28 and zone 30 is wired with a cu,,alantd~ wire in order to w0 96/00042 2 1 9 3 9 6 4 P~ 12 receive RF energy from an RF energy source. A copper wire is connected to each Gu~ ldllldll wire. This results in the fommation of a T type thermocouple "TC .
RF power can be sequentially supplied to each electrode 28 to feedwire 34 in ribbon connector 38 or it can be applied to only certain selected feedwires 34 enabling only selected electrodes 28 along with the electrolytic solution in zones 30 to deliver RF and themmal energy individually to the endu",c:llium. In this way electrodes 28 can be mu:tiplexed. The sizes of individual electrodes 28 are designed to provide the correct current density.
Referring now to Figure 11 segments 51 in a cut-away view is shown with insulator 39 removed in order to show the plurality of segments 51 and their ~lalior~s~ J to t~A~Jdnddble member 12. Cle~l~udes 28 can also be positioned on support member 49. Printed circuit 28 can be fomled by etching deposition or lithography methods well known to those skilled in the art. Printed circuit 28 is fommed of individual segments 51 and is capable of multiplexing so that only certain segments deliver RF energy at a particular time period. Although segments 51 are separated from conductive surface 31 of second fluid conduit 27 they provide individual ablative coverage and delivery ~or the entire conductive surface 31. In this regard the plurality of segments 51 provide ablative regions individually everywhere on conductive surface 31. Because segments 51 are not directly positioned adjacent to or on the exterior surface of eAt,d" ;~dblt: member 12 and with the inclusion of insulator 40 to isolate segments 51 from first fluid conduit 25 there is a selective: ~ of ablative energy to the el ldu,, It:ll ium.
The selectivity can be even , of RF energy everywhere it is applied to the t "do" ,~ ~ ium so that the same depth of endc " ,~ t~ ium is ablated everywhere or the amount of applied energy can be variable depe"u;"g on the ~ hdldul~:ri~ a of the endu",~t,i.lm surface. In this WO 96/00042 2 1 9 3 9 ~ ~ P~ .2 ~

instance, certain sections of the endometrium will have more tissue ablated than other sections. The problems of uneven p~n~ of energy, shown in Figure 5(c), are overcome by aa~ ' ,i"g partially insulated electrodes 28 between first fluid conduit 25 and second fluid conduit, orfoam, 27.
As shown in Figure 12, a plurality of filaments 51 can be optionally included in second fluid conduit 27. These help direct RF energy to conductive surface 31.
Referring now to Figure 13, one or more i" ".edd". e monitors 4û can be used to confimm, before an ablation event, that good coupling of energy is achieved. Also included is one or more temperature Illull:'ula/sellsola 42. Themmal sensors 42 are conventional Il ,~ ula or themmocouples, and are positioned adjacent to or on electrodes 28. Cle~lludes 28 are capable of monitoring circuit continuity. I",l,edd"~,e is monitored between each electrode 28 and zone 30 and a ground electrode when operated in a I l lonu~Juldl mode, or between electrodes 20 operating in a bipolar mode.
In Figure 14, a cross-sectional view of core lumen 15 shows that a variety of conduits, wires and fibers are housed in the lumen. These include, but are not limited to, viewing and illumination optical hbers 44, well known to those skilied in the art, which can deliver light, such as from a ,~enon source, to viewing optics 46 (Figures 1 (a),1 (b) and 1 (c)) a tension wire 48 that connects to hinge 18; an RF cable 50 ~,UI ll le.,tll ly feedwires 34 to an RF source; an electrolytic solution delivery conduit 52 with r~
fluid distribution port 21; and an electrical lead 54 which couples an ultrasound energy source 56 to one or more transducers 58.
Viewing optics 46 can be a 70 degree lens, which perrnits a lateral field of view. Additionally, the cu" ,l,i, " , of optical fibers 44 and viewing optics 46 can be in the forrn of a fiexible viewing scope that is capable of providing a full field of view within the interior of the uterus.
A two-way valve is included with delivery conduit 52. A pump or other similar device advances electrolytic solution to and from tl~JdncldLle 3û

~ W096/00042 2 1 93'~

member 12 through delivery conduit 52. When the procedure is completed, electrolytic solution is removed from expdll iaiJlt member 12 through delivery conduit 52. Core lumen 15 is then rotated, in a twisting ~ type of motion, in order to helically wrap the entire ablation apparatus 1 û, e.g., t:xpdlldaiJle member 12 and cullfulll,i,lg member 20 around core lumen 15. Substantially all of the electrolytic solution is removed. Ablation apparatus 10 is then retracted back into introducer sleeve 14. It is then removed from the uterus. A~ " "~cly, the entire ablation apparatus 10 can be retracted directly into introducer sleeve 14.
Electrolytic solution source 72 can include a pump/pressure flow control device 80, as is well known to those skilled in the art. A heating device 82, for heating the electrolytic solution, is ,.~,o.; ' d with electrolytic solution source 72, or it can be positioned in ~,udllddiJlt: member 12.
Suitable heating devices include but are not limited to coils, bipolar electrodes, catalysts, and other devices, as are well known to those skilled in the art. An ultrasound source 84 is coupled to one or more ultrasound transduoers 58 that are positioned in or on ,;u"' ~ 9 member 20.
Ultrasound transducers 58 can be positioned apart from co,.'u""i"9 member 20. An output is ' ' with ultrasound source 84 and RF
energy source 68.
Each ultrasound transducer 58 can include a ~ Id" crystal mounted on a backing material. An uitrasound lens, fabricated on an electrically insulating material, is mounted between the l .;~ . crystal and cu,,'~ ",i"g member 20. The pj~ , crystal is collll~ultd by electrical leads 54 to ultrasound power source 86. Each ultrasound transducer 58 transmits ultrasound energy through cul ,ful l l ,i, ,9 member 20 into adjacent tissue. Ultrasound transducers 58 can be in the fomm of an imaging probe such as Model 21362, manufactured and sold by Hewlett Packard Company, Palo Alto, California.

wo s6/00042 2 1 9 3 9 6 4 ~ 12 ~

Thermal sensors 42 permit accurate d~t~ ;ou of the surface temperature of the t:ndullleL,i.lm at conductive surface 24 adjacent to ultrasound transducers 58. Thenmal sensors 42 are in themmal proximity to the pi~ PIP. Il iU crystals.
As previously mentioned, ablation apparatus 10 can be used with a variety of different body organs or lumens including the uterus.
Electrodes 28 and zones 30 can be activated to ablate the endu~ t.ium.
Ablation apparatus 10 can be multiplexed and deliver RF and themmal energy to only certain sections of the endometrium. Each zone 30 can provide 50 watts or less of power.
As previously ",e"Liol,ed, ablation apparatus 10 can be used with a variety of different body organs. In Figure 15, ablation apparatus 10 is positioned and retained in the uterus 36. Cl~_L~udes 38 or individual or a plurality of segments 51 can be activated to ablate the e~Ju~ tdum.
Ablation apparatus 10 is multiplexed and delivers RF energy to only certain sections of the endometrium so that, for instance, segment 51(a) is first activated, then segment 51(b), segment 51(c) and so on. For example, each segment can provide 51 watts or less of power.
Refen ing now to Figure 16, a power supply 86 feeds energy into RF
power generator (source) 68 and then to ablation apparatus 10. A
multiplexer 88 measures current, voltage and temperature, at the numerous temperature sensors, going to each electrode 28 and zone 30 of ablation apparatus 10. Electrodes 28 and zones 30 can be individually measuredduringanablationeventatthatparticularsensor. I A- tji 1 88 is driven by controller 78, which can be a digital or analog controller, or a computer with software. When controller 78 is a computer, it can include a CPU coupled through a system bus. This system can include a keyboard, a disk drive, or other non-volatile memory systems, a display, and other pe, i~Jh~ , as known in the art. Also coupled to the bus are a program memory and a data memory.

=

WO96/00042 2l 93964 r~ 12 An operator interface 90 includes operator controls 92 and a display 94. Controller 78 is coupled to the imaging systems, including transducers 58, thermal sensors 42, flexible circuit 34 (current and voltage), and viewing optics 46 and optical fibers 44.
Current and voltage are used to calculate i" I,Ueddl ,ce. Temperature and i",~,eda"~.e are measured and then treatment can begin. Preferably, only one electrode 28 and zone 30 ablates at a time. Diagnostics are done either opticaliy or through ultrasound. Diay"usti~ can be performed both before ablation of the endu",t~ lm, and also after ablation as a check to ascertain the effectiveness of the treatment.
Thermal sensors 42, and sensors contained within RF energy source 68, measure voltage and current that is delivered to the endu,,,~l,ium. The output for these sensors is used by controller 78 to control the delivery of RF power. Controller 78 can also control temperature and power. An operator set level of power, and/or temperature, may be d~ l " ,i"ed and this wiil not be exceeded. Controller 78 rnaintains the set level under changing conditions. The amount of RF
and thermal energy delivered controls the amount of power. A profile of power delivered can be il ,-,~" ,uu, ' ' in controller 78, as well as a pre-set amount of energy to be delivered can also be profiled.
Feedback can be the measurement of i, ,,,ueddnue or temperature.
It occurs either at controller 78, or at RF energy source 68 if it i"~,o".
a controller. I,,,,uedd,,ce measurement can be achieved by supplying a small amount of non-therapeutic RF energy. Voltage and current are then measured to confirm electrical contact.
Circuitry, software and feedback to controller 78 result in full process control and are used to change, (i) power (modulate) - including RF, incuht:l~l ll light" "i~ avc, ultrasound and thP like, (ii) the duty cycle (on-off and wattage), (iii) IllUllUI~Oldl or bipolar energy delivery, (iv) fluid (electrolyte/saline) delivery, temperature of the fiuid, flow rate and pressure wos6/00042 2l 9396~ 12 and (v) determine when ablation is completed through time Lt:",~Je, Ire andlor i" ,ue-6"ce. These process variables can be controlled and varied based on tissue temperature monitored at multiple sites on the ablating surface and i" ,~ edanu~ to current flow monitored at each electrode 28 and zone 30 indicating changes in current carrying capability of the tissue during the ablative process. Additionally controller 78 can provide multiplexing monitor circuit continuity and/or determine which electrode 28 and zone 30 is activated.
A block diagram of one t:lllbodi",~:"l of suitable p~uues~ 9 circuitry is shown in Figure 17. Themmal sensors 42 and transducers 58 are connected to the input of an analog amplifier 96. Themmal sensors 42 can be lll~lllli~lula which have a resistance that varies with temperature.
Analog amplifier 96 can be a c~ liul1dl differential amplifier circuit for use with lht:lllli ,l.~l:, and transducers. The output of analog amplifier is sequentially connected by an analog multiplexer 98 to the input of an analog to digital converter 100. The output of amplifier 96 is a voltage which ~ at:"tS the respective sensed temperatures. The digitized amplifier output voltages are supplied by analog to digital converter 100 to a l~k ~uylucessul 1û2. Mk lu~JIu~a:,or 102 calculates the ll~ re or i,,,,uedance of the tissue. ~r u,ulu~.~SSOI 102 can be a type 680ûO.
However it will be d~ Hdl~:d that any suitable ~ Uul U~ e~ul or general purpose digital or analog computer can be used to calculate i",,uedd", e or ~ ,u~ re.
~' uu~uGe:~sul 102 sequentially receives and stores digital ,t~ ael ItdliOlls of i" ,ue-ld"ce and temperature at electrodes 28 and zones 30. Each digital value received by l"i. ,uu,u~ e~aul 102 Co~ lJollda to different temperatures and i",~Jadd"~.es.
Calculated temperature and i",uedd""e values can be indicated on display 94. /'.' " lt;~cly or in additional to the numerical indication of temperature or i" ,ue,id"u~. calculated i" ",edd""e and l~ re values WO 96/00042 2 1 9 3 9 6 ~ r ~ 12 can be compared by " ,i., up, u~ essur 102 with L~" ,ue, ' ~e and i, Il,Ueddl ,ue limits. When the values exceed u,t:d~Ll:""i"ed Ll:",pe, ~re or i,,,u~-ld,,~e values a warning can be given on display 94 and r~ IY, the delivery of RF energy to that electrode 28 and zone 30 is then ~ulLiult:xed to another electrode 28 and zone 30. A control signal from ~iu~uu~ucessv~
1U2 can reduce the power level supplied by RF power source 68, or det:"~lyi~l: the power delivered to a particular electrode 28 and zone 30.
Thus controller 78 receives and stores the digital values which represent temperatures and i~ ~ ~ueda"- t:s sensed. CA~ '~d surface l~ res and i" ,uec6, Ic~s can be forwarded by controller 78 to display 94. If desired the calculated surface temperature of the e, nlO" ~e:ll ium is compared with a temperature limit and a warning signal can be sent to display 94. Similarly a control signal can be sent to RF energy source 68 when temperature or i,,,ueda,,ce values exceed a prcd~ .~.",i"ed level.
The foregoing desw n of preferred e" IL,odi" ,~"t~, of the present invention has been provided for the purposes of illustration and dt~
It is not intended to be exhaustive or to limit the invention to the precise forms disclosed. Obviously many ", ~ ~ and variations will be apparent to U~d~ LiLiune, ~ skilled in this art. The ~" Ibudil "e~ It~ were chosen 2U and described in order to best explain the principles of the invention and its practical: n thereby enabling others skilled in the art to ulld~l~ld~d the invention for various t:~nbudillle:l~t~ and with various ~llouifildLiul~ as are suited to the particular use cu" " ~ It is intended that the scope of the invention be def ned by the following claims and their equivalents.
Vvhat is claimed is:

. ! ! ;L ~ "~ t ~ fi~~

Claims (45)

1. An apparatus for ablating an inner layer of an organ or body lumen, comprising:
an expandable member having an interior section for housing an electrolytic solution;
a conforming member made of a material capable of substantially conforming to a portion of the inner layer of the organ, the conforming member delivering the electrolytic solution housed within the expandable member to the inner layer of the organ;
one or more electrodes positioned in or on the conforming member for delivering RF energy to the inner layer of the organ;
an electrical connector device connecting the one or more electrodes to an RF energy source; and an electrolytic solution delivery tube for delivering an electrolytic solution from the electrolytic solution source to the expandable member.
2. The ablation apparatus according to claim 1, wherein the expandable member includes a plurality of apertures through which the electrolytic solution flows from the expandable member.
3. The ablation apparatus according to claim 2, wherein the expandable member is formed of a nonporous material
4. The ablation apparatus according to claim 3, wherein the expandable member is positioned within the conforming member.
5. The ablation apparatus according to claim 1, further comprising:
a membrane positioned between the expandable member and the conforming member, the membrane adapted to receive the electrolytic solution from the expandable member and deliver the electrolytic solution to the conforming member.
6. The ablation apparatus according to claim 1, wherein the one or more electrodes form a printed circuit that is multiplexed.
7. The ablation apparatus according to claim 6, wherein the printed circuit includes a plurality of segments.
8. The ablation apparatus according to claim 1, wherein the organ is the uterus and the inner layer is the endometrium.
9. An apparatus for ablating an inner layer of an organ or body lumen, comprising:
an expandable member having an interior section for housing an electrolytic solution;
a conforming member made of a material capable of substantially conforming to a portion of the inner layer of the organ, the conforming member delivering the electrolytic solution housed within the expandable member to the inner layer of the organ;
one or more electrodes positioned in or on the conforming member for delivering RF energy to the inner layer of the organ;
an electrical connector device connecting the one or more electrodes to an RF energy source;
an electrolytic solution delivery tube for delivering electrolytic solution from an electrolytic solution source to the expandable member;

and a feedback device which monitors a characteristic of the inner layer and, in response, controls the delivery of RF energy to the one or more electrodes.
10. The ablation apparatus according to claim 9, wherein the feedback device monitors an impedance of the inner layer at a portion of the inner layer.
11. The ablation apparatus according to claim 9, wherein the feedback device monitors a temperature of the inner layer at a portion of the inner layer.
12. The ablation apparatus according to claim 9, wherein the feedback device includes a controller.
13. The ablation apparatus according to claim 12, wherein the feedback device includes a multiplexer.
14. The ablation apparatus according to claim 9, wherein the one or more electrodes are multiplexed.
15. The ablation apparatus according to claim 9, wherein the one or more electrodes form a printed circuit.
16. The ablation apparatus according to claim 15, wherein the printed circuit includes one or more impedance monitors.
17. The ablation apparatus according to claim 16, wherein the printed circuit includes one or more temperature monitors.
18. The ablation apparatus according to claim 15, wherein the feedback device monitors continuity of the circuit.
19. An apparatus for ablating an inner layer of an organ or body lumen, comprising:
an expandable member having an interior section for housing an electrolytic solution;
a conforming member made of a material capable of substantially conforming to a portion of the inner layer of the organ, the conforming member delivering the electrolytic solution housed within the expandable member to the inner layer of the organ;
a plurality of electrodes positioned in or on the conforming member for delivering RF energy to the inner layer of the organ, each electrode including an insulator formed on a surface of the electrode;
an electrical connector device connecting the one or more electrodes to an RF energy source; and an electrolytic solution delivery tube for delivering the electrolytic solution from an electrolytic solution source to the expandable member.
20. The ablation apparatus according to claim 19, wherein the plurality of RF electrodes are positioned on a support member.
21. The ablation apparatus according to claim 19, wherein the plurality of electrodes form a flexible circuit.
22. The ablation apparatus according to claim 21, wherein the flexible circuit is a printed circuit.
23. The ablation apparatus according to claim 19, wherein the expandable member is expanded mechanically.
24. The ablation apparatus according to claim 19, wherein the expandable member is formed of a nonporous material.
25. The ablation apparatus according to claim 19, wherein the conforming member is made of a foam.
26. The ablation apparatus according to claim 19, wherein the expandable member is formed of an insulating material.
27. The ablation apparatus according to claim 26, wherein the plurality of electrodes form a flexible circuit.
28. The ablation apparatus according to claim 27, wherein the flexible circuit is a printed circuit.
29. The ablation apparatus according to claim 26, wherein the expandable member is expanded mechanically.
30. The ablation apparatus according to claim 26, wherein the expandable member is formed of a nonporous material.
31. The ablation apparatus according to claim 26 wherein the conforming member is made of a foam.
32. An apparatus for ablating an inner layer of an organ or body lumen, comprising:
an expandable member having an interior section for housing an electrolytic solution;
a conforming member made of a material capable of substantially conforming to a portion of the inner layer of the organ, the conforming member delivering the electrolytic solution housed within the expandable member to the inner layer of the organ, the conforming member including non-zone areas with a first porosity rate for delivering electrolytic solution to the inner layer and zone areas for housing an electrode and electrolytic solution, the zone areas having a second porosity rate that is less than the first porosity rate such that the electrolytic solution passes through the zone areas at a slower rate than through the non-zone areas;
one or more electrodes positioned in or on the conforming member for delivering RF energy to the inner layer of the organ;
an electrical connector device connecting the one or more electrodes to an RF energy source; and an electrolytic solution delivery tube for delivering the electrolytic solution from an electrolytic solution source to the expandable member.
33. The ablation apparatus according to claim 32, wherein the conforming member is made of an open cell material.
34. The ablation apparatus according to claim 32, wherein the conforming member is made of an open cell material, and the zone areas have less open cells than the non-zone areas.
35. The ablation apparatus according to claim 34, wherein the conforming member is made of an open cell foam.
36. The ablation apparatus according to claim 32, wherein the conforming member is formed of two pieces of open cell foam material sealed together in the non-zone areas.
37. The ablation apparatus according to claim 32, wherein the conforming member is two pieces of open cell foam material that are sealed together in the zone.
38. The ablation apparatus according to claim 32, wherein the ablation apparatus includes a plurality of electrodes.
39. The ablation apparatus according to claim 32, wherein each electrode of the plurality of electrodes is associated with a particular zone.
40. The ablation apparatus according to claim 32, further comprising:
a groundpad electrode attached to an exterior surface of a patient.
41. The ablation apparatus according to claim 32, further comprising:
the electrolytic solution source; and a fluid delivery device for delivering electrolytic solution from the electrolytic solution source to the interior of the expandable member.
42. The ablation apparatus according to claim 32, further comprising:
a heating device positioned within the expandable member.
43. The ablation apparatus according to claim 32, wherein the expandable member is expandable mechanically.
44. The ablation apparatus according to claim 32, wherein the expandable member is expandable by a fluidic medium.
45. The ablation apparatus according to claim 44, wherein the fluid medium is the electrolytic solution.
CA002193964A 1994-06-24 1995-06-23 Thin layer ablation apparatus Abandoned CA2193964A1 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US08/265,459 US5505730A (en) 1994-06-24 1994-06-24 Thin layer ablation apparatus
US08/265,459 1994-06-24
US08/272,162 US5569241A (en) 1994-06-24 1994-07-07 Thin layer ablation apparatus
US08/272,162 1994-07-07
US08/286,862 US5558672A (en) 1994-06-24 1994-08-04 Thin layer ablation apparatus
US08/286,862 1994-08-04
US31937395A 1995-02-06 1995-02-06
US08/319,373 1995-02-06

Publications (1)

Publication Number Publication Date
CA2193964A1 true CA2193964A1 (en) 1996-01-04

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Application Number Title Priority Date Filing Date
CA002193964A Abandoned CA2193964A1 (en) 1994-06-24 1995-06-23 Thin layer ablation apparatus

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US (4) US5505730A (en)
EP (1) EP0767629A1 (en)
AU (1) AU707548B2 (en)
CA (1) CA2193964A1 (en)
WO (1) WO1996000042A1 (en)

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US5505730A (en) 1996-04-09
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US5827273A (en) 1998-10-27
WO1996000042A1 (en) 1996-01-04

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