CA2199516A1 - Needle-less parenteral introduction device - Google Patents

Needle-less parenteral introduction device

Info

Publication number
CA2199516A1
CA2199516A1 CA002199516A CA2199516A CA2199516A1 CA 2199516 A1 CA2199516 A1 CA 2199516A1 CA 002199516 A CA002199516 A CA 002199516A CA 2199516 A CA2199516 A CA 2199516A CA 2199516 A1 CA2199516 A1 CA 2199516A1
Authority
CA
Canada
Prior art keywords
medicament
barrel member
bore
patient
skin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002199516A
Other languages
French (fr)
Other versions
CA2199516C (en
Inventor
Roland Cherif-Cheikh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Pharma SAS
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA2699271A priority Critical patent/CA2699271C/en
Publication of CA2199516A1 publication Critical patent/CA2199516A1/en
Application granted granted Critical
Publication of CA2199516C publication Critical patent/CA2199516C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0069—Devices for implanting pellets, e.g. markers or solid medicaments

Abstract

A needle-less device for the parenteral administration of a medicament is disclosed. The medicament has the shape of one end of a toothpick. It is palced in the bore of a barrel with the barrel having the shape of a nose cone at one end. A plunger is inserted into the other end of the bore. The plunger forces the medicament through the skin and into the subcutaneous layer of the patient without the need for penetration of the skin by a needle.

Claims (24)

1. A needle-less device capable of parenteral administration of a medicament, said device comprising a barrel member and a plunger, said barrel member having first and second ends and a bore for receipt of said medicament in solid form, said bore extending from said first end to said second end of said barrel, said plunger comprising an elongated rod of substantially the same outside diameter as the inside diameter of said bore, said rod being inserted into the bore at said second end of said barrel, said plunger being capable of movement in said bore to push said medicament out said first end of the barrel member, through the skin of a patient when said barrel member is pressed against the skin of the patient and when the medicament is of sufficient structural strength to penetrate the skin of the patient.
2. The device of claim 1 further comprising a sleeve, said sleeve being affixed to said plunger and said sleeve being in sliding engagement with the exterior surface of said barrel member, said sleeve having first and second ends.
3. The device of claim 2 wherein said barrel includes two spaced protruding ring members, and wherein said first end of said sleeve has an inwardly extending shoulder, said inwardly extending shoulder retaining said one end of said sleeve in sliding movement on said barrel member between said two ring members on said barrel.
4. The device of claim 2 wherein the plunger comprises a rod affixed to an end cap, said second end of said sleeve being affixed to said end cap.
5. The device of claim 4 wherein said second end of sleeve is affixed to the end cap by frictional engagement.
6. The device of claim 2 further comprising a second shoulder extending inwardly from said sleeve, said second shoulder being spaced from the first shoulder, said second shoulder in combination with one of said protruding ring members on the barrel member limiting the travel of the plunger rod in said bore of the barrel member.
7. The device of claim 6 wherein the limit of travel of said rod is such that no more than about 2 mm of the rod extends beyond said first end of the barrel member.
8. The device of claim 6 wherein the limit of travel of said rod is such that none of the rod of the plunger member extends beyond said first end of the barrel member.
9. The device of claim 1 wherein said first end of the barrel member has a nose cone shape.
10. The device of claim 1 further comprising a medicament in the bore of the barrel member.
11. The device of claim 10 wherein the medicament has the shape of one end of a toothpick and includes a point with a taper back to a cylindrical portion and wherein said point in said bore is aligned towards said first end of the barrel member.
12. The device of claim 11 wherein the medicament has a diameter in the cylindrical portion of from about 0.2 to about 2 mm and the overall length of the medicament is from about 1 mm to about 5 cm.
13. The device of claim 10 further comprising a seal of a biologically compatible material covering the end of said bore located at said first end of said barrel member.
14. The device of claim 13 wherein the biologically compatible material is selected from the group consisting of cellulose and gelatin.
15. A medicament adapted to be administered parenterally to a patient, said medicament having a diameter of from about 0.2 to about 2 mm and a length of from about 1 mm to about 5 cm, and said medicament having sufficient structural integrity to penetrate the skin of the patient.
16. The medicament of claim 15 wherein said medicament comprises substantially 100% active ingredient.
17. The medicament of claim 15 wherein the diameter of said medicament is from about 0.2 to about 0.8 mm.
18. The medicament of claim 15 wherein the diameter of said medicament is from about 0.25 to about 0.50 mm.
19. The medicament of claim 15 wherein the medicament has a crush strength of at least about 8 killipoise in the longitudinal direction.
20. The medicament of claim 15 wherein said medicament has the shape of a toothpick with a frustoconical point at one end thereof.
21. A medicament adapted to be administered parenterally, said medicament comprising at least about 10% active ingredient, said medicament having a diameter of from about 0.2 to about 2 mm and a length of from about 1 mm to about 5 cm, and said medicament having a crush strength of at least about 8 killipoise in the longitudinal direction.
22. The medicament of claim 21 wherein the diameter of said medicament is from about 0.2 to about 0.8 mm.
23. A method of administering a medicament parenterally to a patient without the use of a needle, said method comprising bringing a medicament having a sufficient structural strength to penetrate the patient's skin into contact with the patient's skin and forcing the medicament through the skin.
24. A needle-less device capable of parenteral administration of a medicament, said device comprising a barrel member and a gas supply mechanism, said barrel member having first and second ends and a bore for receipt of said medicament in solid form, said bore extending from said first end to said second end of said barrel, said gas supply mechanism comprising a reservoir, a gas supply valve and an operating button, said operating button being depressible to allow gas to flow from said reservoir through said valve and into said barrel member, said gas being capable of moving said medicament in said bore to push said medicament out said first end of the barrel member and through the skin of a patient when said barrel member is pressed against the skin of the patient and said button is depressed and when the medicament is of sufficient structural strength to penetrate the skin of the patient.
CA2199516A 1994-09-12 1995-09-12 Needle-less parenteral introduction device Expired - Lifetime CA2199516C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2699271A CA2699271C (en) 1994-09-12 1995-09-12 Needle-less parenteral introduction device

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/304,274 1994-09-12
US08/304,274 US5542920A (en) 1994-09-12 1994-09-12 Needle-less parenteral introduction device
PCT/IB1995/000841 WO1996008289A1 (en) 1994-09-12 1995-09-12 Needle-less parenteral introduction device

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2699271A Division CA2699271C (en) 1994-09-12 1995-09-12 Needle-less parenteral introduction device

Publications (2)

Publication Number Publication Date
CA2199516A1 true CA2199516A1 (en) 1996-03-21
CA2199516C CA2199516C (en) 2010-06-08

Family

ID=23175806

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2699271A Expired - Lifetime CA2699271C (en) 1994-09-12 1995-09-12 Needle-less parenteral introduction device
CA2199516A Expired - Lifetime CA2199516C (en) 1994-09-12 1995-09-12 Needle-less parenteral introduction device

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA2699271A Expired - Lifetime CA2699271C (en) 1994-09-12 1995-09-12 Needle-less parenteral introduction device

Country Status (12)

Country Link
US (4) US5542920A (en)
EP (1) EP0782465B1 (en)
JP (2) JPH10505526A (en)
KR (2) KR100261580B1 (en)
AT (1) ATE173941T1 (en)
AU (1) AU705266B2 (en)
BR (1) BR9508830A (en)
CA (2) CA2699271C (en)
DE (1) DE69506428T2 (en)
DK (1) DK0782465T3 (en)
ES (1) ES2125657T3 (en)
WO (1) WO1996008289A1 (en)

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Also Published As

Publication number Publication date
KR100359587B1 (en) 2002-11-07
CA2699271C (en) 2013-10-22
KR100261580B1 (en) 2000-07-15
DK0782465T3 (en) 1999-08-16
EP0782465B1 (en) 1998-12-02
US6120786A (en) 2000-09-19
ES2125657T3 (en) 1999-03-01
WO1996008289A1 (en) 1996-03-21
CA2699271A1 (en) 1996-03-21
AU705266B2 (en) 1999-05-20
CA2199516C (en) 2010-06-08
EP0782465A1 (en) 1997-07-09
AU3531595A (en) 1996-03-29
ATE173941T1 (en) 1998-12-15
DE69506428T2 (en) 1999-06-02
US6896893B2 (en) 2005-05-24
BR9508830A (en) 1998-11-03
DE69506428D1 (en) 1999-01-14
US6117443A (en) 2000-09-12
US5542920A (en) 1996-08-06
US20030082216A1 (en) 2003-05-01
JPH10505526A (en) 1998-06-02
JP2006320736A (en) 2006-11-30

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