CA2201725A1 - Composition, device and method for electrotransport agent delivery - Google Patents
Composition, device and method for electrotransport agent deliveryInfo
- Publication number
- CA2201725A1 CA2201725A1 CA002201725A CA2201725A CA2201725A1 CA 2201725 A1 CA2201725 A1 CA 2201725A1 CA 002201725 A CA002201725 A CA 002201725A CA 2201725 A CA2201725 A CA 2201725A CA 2201725 A1 CA2201725 A1 CA 2201725A1
- Authority
- CA
- Canada
- Prior art keywords
- composition
- body surface
- electrotransport
- agent delivery
- applying
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
Abstract
An electrotransport drug-containing composition is provided. The composition includes a drug to be delivered through a body surface (e.g., skin) of a patient, and a permeation enhancer which is solid or semisolid at temperatures typically encountered during storage of pharmaceuticals (e.g., temperatures up to at least about 25 °C). The composition of the invention may be applied from a device (10) suitable for electrotransport delivery. A method for increasing electrotransport agent delivery rate and reducing body surface resistance relies on applying the composition of the invention to the body surface, and applying an electric current through the composition and the body surface.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/338,924 | 1994-11-14 | ||
US08/338,924 US5736580A (en) | 1994-11-14 | 1994-11-14 | Composition, device, and method for electrotransport agent delivery |
PCT/US1995/014091 WO1996014869A1 (en) | 1994-11-14 | 1995-11-01 | Composition, device, and method for electrotransport agent delivery |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2201725A1 true CA2201725A1 (en) | 1996-05-23 |
CA2201725C CA2201725C (en) | 2008-06-03 |
Family
ID=23326715
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002201725A Expired - Fee Related CA2201725C (en) | 1994-11-14 | 1995-11-01 | Composition, device and method for electrotransport agent delivery |
Country Status (11)
Country | Link |
---|---|
US (3) | US5736580A (en) |
EP (1) | EP0789589B1 (en) |
JP (1) | JP4049389B2 (en) |
AT (1) | ATE369150T1 (en) |
CA (1) | CA2201725C (en) |
DE (1) | DE69535556T2 (en) |
DK (1) | DK0789589T3 (en) |
ES (1) | ES2292171T3 (en) |
HK (1) | HK1000450A1 (en) |
PT (1) | PT789589E (en) |
WO (1) | WO1996014869A1 (en) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
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US6956032B1 (en) * | 1986-04-18 | 2005-10-18 | Carnegie Mellon University | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods |
US8321013B2 (en) * | 1996-01-08 | 2012-11-27 | Impulse Dynamics, N.V. | Electrical muscle controller and pacing with hemodynamic enhancement |
US8825152B2 (en) | 1996-01-08 | 2014-09-02 | Impulse Dynamics, N.V. | Modulation of intracellular calcium concentration using non-excitatory electrical signals applied to the tissue |
US9289618B1 (en) | 1996-01-08 | 2016-03-22 | Impulse Dynamics Nv | Electrical muscle controller |
US7167748B2 (en) | 1996-01-08 | 2007-01-23 | Impulse Dynamics Nv | Electrical muscle controller |
JP4175662B2 (en) | 1996-01-08 | 2008-11-05 | インパルス ダイナミクス エヌ.ヴイ. | Electric muscle control device |
US9713723B2 (en) | 1996-01-11 | 2017-07-25 | Impulse Dynamics Nv | Signal delivery through the right ventricular septum |
US5676648A (en) | 1996-05-08 | 1997-10-14 | The Aps Organization, Llp | Iontophoretic drug delivery apparatus and method for use |
US6385487B1 (en) | 1996-05-08 | 2002-05-07 | Biophoretic Therapeutic Systems, Llc | Methods for electrokinetic delivery of medicaments |
US6119036A (en) * | 1997-03-26 | 2000-09-12 | The Board Of Regents Of The University Of Oklahoma | Iontophoretic transdermal delivery device |
ATE373957T1 (en) | 1997-10-09 | 2007-10-15 | Univ Emory | METHOD AND DEVICE FOR TRANSDERMAL ADMINISTRATION OF LITHIUM |
EP0922467A3 (en) * | 1997-12-12 | 2000-05-24 | Takeda Chemical Industries, Ltd. | Iontophoretic drug delivery |
USRE37796E1 (en) | 1997-12-16 | 2002-07-23 | Biophoretic Therapeutic Systems, Llc | Methods for iontophoretic delivery of antiviral agents |
US6374136B1 (en) * | 1997-12-22 | 2002-04-16 | Alza Corporation | Anhydrous drug reservoir for electrolytic transdermal delivery device |
US6148231A (en) * | 1998-09-15 | 2000-11-14 | Biophoretic Therapeutic Systems, Llc | Iontophoretic drug delivery electrodes and method |
US9101765B2 (en) | 1999-03-05 | 2015-08-11 | Metacure Limited | Non-immediate effects of therapy |
US8019421B2 (en) * | 1999-03-05 | 2011-09-13 | Metacure Limited | Blood glucose level control |
WO2006073671A1 (en) | 2004-12-09 | 2006-07-13 | Impulse Dynamics Nv | Protein activity modification |
US8666495B2 (en) | 1999-03-05 | 2014-03-04 | Metacure Limited | Gastrointestinal methods and apparatus for use in treating disorders and controlling blood sugar |
US8700161B2 (en) | 1999-03-05 | 2014-04-15 | Metacure Limited | Blood glucose level control |
US6477410B1 (en) * | 2000-05-31 | 2002-11-05 | Biophoretic Therapeutic Systems, Llc | Electrokinetic delivery of medicaments |
US7127285B2 (en) * | 1999-03-12 | 2006-10-24 | Transport Pharmaceuticals Inc. | Systems and methods for electrokinetic delivery of a substance |
US6792306B2 (en) | 2000-03-10 | 2004-09-14 | Biophoretic Therapeutic Systems, Llc | Finger-mounted electrokinetic delivery system for self-administration of medicaments and methods therefor |
DE19923427A1 (en) * | 1999-05-21 | 2000-11-23 | Lohmann Therapie Syst Lts | Device for improved delivery of active agents to skin, useful e.g. for administering opiates, contains agent that increases local skin temperature or blood flow |
US7092753B2 (en) * | 1999-06-04 | 2006-08-15 | Impulse Dynamics Nv | Drug delivery device |
US7171263B2 (en) * | 1999-06-04 | 2007-01-30 | Impulse Dynamics Nv | Drug delivery device |
US7190997B1 (en) | 1999-06-04 | 2007-03-13 | Impulse Dynamics Nv | Drug delivery device |
US7069226B1 (en) | 1999-07-07 | 2006-06-27 | Synetic, Incorporated | Prescription data processing system for determining new therapy starts |
JP4879433B2 (en) * | 2000-01-13 | 2012-02-22 | エミスフェアー・テクノロジーズ・インク | Compounds and compositions for delivering active agents |
GB0017999D0 (en) | 2000-07-21 | 2000-09-13 | Smithkline Beecham Biolog | Novel device |
CA2500713C (en) * | 2002-10-04 | 2012-07-03 | Photokinetix, Inc. | Photokinetic delivery of biologically active substances using pulsed incoherent light |
JP2006519663A (en) | 2003-03-10 | 2006-08-31 | インパルス ダイナミックス エヌヴイ | Apparatus and method for delivering electrical signals for regulating gene expression in heart tissue |
US11439815B2 (en) | 2003-03-10 | 2022-09-13 | Impulse Dynamics Nv | Protein activity modification |
US8792985B2 (en) | 2003-07-21 | 2014-07-29 | Metacure Limited | Gastrointestinal methods and apparatus for use in treating disorders and controlling blood sugar |
US8352031B2 (en) | 2004-03-10 | 2013-01-08 | Impulse Dynamics Nv | Protein activity modification |
US11779768B2 (en) | 2004-03-10 | 2023-10-10 | Impulse Dynamics Nv | Protein activity modification |
US8296162B1 (en) | 2005-02-01 | 2012-10-23 | Webmd Llc. | Systems, devices, and methods for providing healthcare information |
WO2006097934A2 (en) | 2005-03-18 | 2006-09-21 | Metacure Limited | Pancreas lead |
EP1898991B1 (en) | 2005-05-04 | 2016-06-29 | Impulse Dynamics NV | Protein activity modification |
US8380530B2 (en) * | 2007-02-02 | 2013-02-19 | Webmd Llc. | Personalized health records with associative relationships |
US8197844B2 (en) | 2007-06-08 | 2012-06-12 | Activatek, Inc. | Active electrode for transdermal medicament administration |
US20090137925A1 (en) * | 2007-11-23 | 2009-05-28 | Divya Cantor | Impedance Spectroscopy Cervix Scanning Apparatus and Method |
US8862223B2 (en) | 2008-01-18 | 2014-10-14 | Activatek, Inc. | Active transdermal medicament patch and circuit board for same |
WO2011046927A1 (en) * | 2009-10-13 | 2011-04-21 | Nupathe,Inc. | Transdermal methods and systems for the delivery of rizatriptan |
US8934975B2 (en) | 2010-02-01 | 2015-01-13 | Metacure Limited | Gastrointestinal electrical therapy |
JP6243102B2 (en) * | 2012-05-01 | 2017-12-06 | 株式会社ジェムインターナショナル | Patch |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5084241A (en) * | 1982-09-20 | 1992-01-28 | V-Tech, Inc. | Apparatus including a sample petter tube for obtaining reproducible liquid samples of small volume |
US5128376A (en) * | 1983-07-01 | 1992-07-07 | Nitto Denko Corporation | Method for percutaneously administering physiologically active agents using an adjuvant a solvent and a diol moderator |
US4605670A (en) * | 1984-02-01 | 1986-08-12 | Nitto Electric Industrial Co., Ltd. | Method for percutaneously administering metoclopramide |
US4722720A (en) * | 1985-04-30 | 1988-02-02 | Nhk Spring Co., Ltd. | Tension providing device |
US4722726A (en) * | 1986-02-12 | 1988-02-02 | Key Pharmaceuticals, Inc. | Method and apparatus for iontophoretic drug delivery |
DE3724691C2 (en) * | 1987-07-25 | 1999-03-18 | Konrad Minninger | Pharmaceutical agent for the local therapy of flaking skin diseases |
ATE91079T1 (en) * | 1989-01-25 | 1993-07-15 | Wolff Chem Pharm Gmbh | SALICYLIC ACID AGENT AGAINST SCALPING SKIN DISEASES. |
US5087242A (en) * | 1989-07-21 | 1992-02-11 | Iomed, Inc. | Hydratable bioelectrode |
US5023085A (en) * | 1989-11-29 | 1991-06-11 | Pfizer Inc. | Transdermal flux enhancers in combination with iontophoresis in topical administration of pharmaceuticals |
US5149719A (en) * | 1990-04-27 | 1992-09-22 | Minnesota Mining And Manufacturing Company | Composition for transdermal penetration of medicaments |
US5087241A (en) * | 1990-07-24 | 1992-02-11 | Empi, Inc. | Iontophoresis electrode with reservoir and injection site |
ES2072134T3 (en) * | 1990-10-29 | 1995-07-01 | Alza Corp | IONTOPHORETICAL ELECTRODE TO SUPPLY DRUGS AND METHOD FOR ITS HYDRATION. |
US5158537A (en) * | 1990-10-29 | 1992-10-27 | Alza Corporation | Iontophoretic delivery device and method of hydrating same |
ATE169826T1 (en) * | 1992-01-21 | 1998-09-15 | Macrochem Corp | IONTOPHORETIC IMPROVED DRUG DELIVERY |
US5310404A (en) * | 1992-06-01 | 1994-05-10 | Alza Corporation | Iontophoretic delivery device and method of hydrating same |
JPH0616538A (en) * | 1992-07-03 | 1994-01-25 | Japan Tobacco Inc | Liquid composition for drug absorption for iontophoresis |
-
1994
- 1994-11-14 US US08/338,924 patent/US5736580A/en not_active Expired - Lifetime
-
1995
- 1995-11-01 ES ES95941347T patent/ES2292171T3/en not_active Expired - Lifetime
- 1995-11-01 WO PCT/US1995/014091 patent/WO1996014869A1/en active IP Right Grant
- 1995-11-01 DK DK95941347T patent/DK0789589T3/en active
- 1995-11-01 EP EP95941347A patent/EP0789589B1/en not_active Expired - Lifetime
- 1995-11-01 JP JP51610896A patent/JP4049389B2/en not_active Expired - Fee Related
- 1995-11-01 PT PT95941347T patent/PT789589E/en unknown
- 1995-11-01 DE DE69535556T patent/DE69535556T2/en not_active Expired - Lifetime
- 1995-11-01 AT AT95941347T patent/ATE369150T1/en active
- 1995-11-01 CA CA002201725A patent/CA2201725C/en not_active Expired - Fee Related
-
1997
- 1997-10-08 HK HK97101906A patent/HK1000450A1/en not_active IP Right Cessation
- 1997-12-05 US US08/985,542 patent/US5811465A/en not_active Expired - Lifetime
- 1997-12-05 US US08/985,511 patent/US6057374A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
PT789589E (en) | 2007-08-31 |
DK0789589T3 (en) | 2007-12-17 |
CA2201725C (en) | 2008-06-03 |
JPH10508849A (en) | 1998-09-02 |
WO1996014869A1 (en) | 1996-05-23 |
ES2292171T3 (en) | 2008-03-01 |
ATE369150T1 (en) | 2007-08-15 |
US5736580A (en) | 1998-04-07 |
DE69535556T2 (en) | 2008-03-06 |
JP4049389B2 (en) | 2008-02-20 |
EP0789589B1 (en) | 2007-08-08 |
DE69535556D1 (en) | 2007-09-20 |
US5811465A (en) | 1998-09-22 |
US6057374A (en) | 2000-05-02 |
HK1000450A1 (en) | 2008-04-03 |
EP0789589A1 (en) | 1997-08-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |