CA2201836A1 - Method for laser surgery - Google Patents

Method for laser surgery

Info

Publication number
CA2201836A1
CA2201836A1 CA002201836A CA2201836A CA2201836A1 CA 2201836 A1 CA2201836 A1 CA 2201836A1 CA 002201836 A CA002201836 A CA 002201836A CA 2201836 A CA2201836 A CA 2201836A CA 2201836 A1 CA2201836 A1 CA 2201836A1
Authority
CA
Canada
Prior art keywords
coherent radiation
skin tissue
laser
pulses
per square
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002201836A
Other languages
French (fr)
Inventor
Ziv Karni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ESC Medical Systems Ltd
Original Assignee
Ziv Karni
Esc Medical Systems Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ziv Karni, Esc Medical Systems Ltd. filed Critical Ziv Karni
Publication of CA2201836A1 publication Critical patent/CA2201836A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/203Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00238Type of minimally invasive operation
    • A61B2017/00243Type of minimally invasive operation cardiac
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743Type of operation; Specification of treatment sites
    • A61B2017/00747Dermatology
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00452Skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00452Skin
    • A61B2018/0047Upper parts of the skin, e.g. skin peeling or treatment of wrinkles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B2018/2015Miscellaneous features
    • A61B2018/2025Miscellaneous features with a pilot laser
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B2018/2065Multiwave; Wavelength mixing, e.g. using four or more wavelengths
    • A61B2018/207Multiwave; Wavelength mixing, e.g. using four or more wavelengths mixing two wavelengths
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61CDENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C1/00Dental machines for boring or cutting ; General features of dental machines or apparatus, e.g. hand-piece design
    • A61C1/0046Dental lasers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/10Hair or skin implants

Abstract

A method of laser surgery, comprising the steps of selecting lasers whose output radiation has appropriate extinction lengths in the tissue to be ablated, coagulated, and/or shrunk, and directing radiation from those lasers coaxially and substantially simultaneously at the tissue.

Description

3 ~
APPLICATION FOR PATENT

Inventor: Ziv Karni Title: METHOD FOR LASER SURGERY

FIELD AND BACKGROUND OF THE INVENTION
The present invention relates to a method for performing laser surgery and, more particularly, to a method for sirnultaneously ablating, coagulating, and/or shrinking biological tissue.
Directing coherent radiation from a laser at a target is a well known method for precisely cutting that target by ablating or vaporizing a portion 10 of it. When the target is living biological tissue, the dynamic nature of the target poses special problems. For example, fluids such as blood may flow into the area of the cut, obscuring that area and absorbing part of the energy that otherwise would go into ablating the target.
This problem can be mitig~tetl by directing beams of coherent 15 radiation of two or more wavelengths at the tissue, one beam to ablate the tissue and the other to perform some other action, such as coagulating small blood vessels to prevent inflow of blood. For exarnple, Freiberg, in U. S. Patent Number 5,139,494, which is incorporated by reference for our purposes as if fully set forth herein, advocates using radiation in a 20 range of wavelengths between about 0.1 and about 0.3 microns, and between about 2.0 and about 12.0 microns, for ablative cutting, and radiation in a range of wavelengths between about 0.3 microns and about 2.0 microns for coagulation. These bearns of coherent radiation are directed coaxially at the tissue to be cut. Suitable means for combining laser beams coaxially are well known in the art. One such means is disclosed by Nakajima in U. S. Patent Number 4,408,602. Another is 5 disclosed by Jako in U. S. Patent Number 4,503,854. Both of these patents are incorporated by reference for all purposes as if fully set forth herein.
Among the surgical procedures to which laser surgery may be applied are skin resurfacing and hair irnplantation. In skin resurfacing, the 10 upper layer of skin is ablated by a first laser bearn while the underlying collagen is coagulated and shrunk by a second laser beam. In hair implantation, the accuracy of the drilling of holes for the implantation of new hair using a first laser beam is enhanced by the use of a second laser beam to coagulate small blood vessels and prevent inflow of blood. Both 15 of these procedures are very delicate and require precise selection and control of the wavelengths, intensities and durations of the laser beams.
There is thus a widely recognized need for, and it would be highly advantageous to have, a more precise method for using lasers to perform delicate surgical procedures such as skin resurfacing and hair implantation.

- ~ 2 Q ~ 8 3 fi SUMMARY OF THE INVENTION
According to the present invention there is provided a method for surgical alteration of skin tissue by simlllt~neous ablation, coa~,ulation, and shrinkage, comprising the steps of: (a) selecting a first coherent radiation 5 source characterized by emitting a first coherent radiation having an extinction length in the skin tissue of between about 0.01 millimeters and about 0.001 millimeters; (b) selecting a second coherent radiation source characterized by emi~tin~ a second coherent radiation having an extinction length in the skin tissue of between about 0.1 millimeters and about 0.01 10 millimeters; (c) directing a first beam of the first coherent radiation at the skin tissue; and (d) directing a second beam of the second coherent radiation at the skin tissue, substantially coaxially and substantially simultaneously with the first beam.
According to the present invention there is provided a method for 15 surgical alteration of skin tissue by simlllt~neous ablation, coagulation, and shrinkage, comprising the steps of: (a) selecting a first coherent radiation source characterized by emitting a first coherent radiation having an extinction length in the skin tissue of between about 0.01 millimeters and about 0.001 millimeters; (b) selecting a second coherent radiation source 20 characterized by emitting a second coherent radiation having an extinction length in the skin tissue of between about one millimeter and about 0.1 millimeters; (c) directing a first beam of the first coherent radiation at the - 220~ 83~

skin tissue; and (d~ directing a second be~m of the second coherent radiation at the skin tissue, substantially coaxially and subst~nti~lly simultaneously with the first beam.
The criteria for selecting the parameters for delicate laser surgery 5 on skin tissue are the desired physical effects. The ablative laser beam should be strongly absorbed by the target tissue, so that the ablative effects of the laser beaIn are confined to the target tissue. Furthermore, the pulse duration should be shorter than the thermal relaxation time of the target tissue, to prevent thermal damage to adjacent tissue, while the pulse 10 intensity should be suf~lciently high to achieve the desired ablation. In skin resurfacing, the laser beam used to shrink the collagen should not be significantly absorbed in the overlying skin, but should be absorbed by the collagen. In hair implantation, the laser bearn used should be absorbed only to an extent suf~lcient to coagulate the capillaries that are cut by the 15 ablative laser beam.
The present invention successfully addresses the shortcomings of the presently known procedures for skin resurfacing and hair implantation by providing an appropliate range of wavelengths, pulse durations, and pulse intensities for the laser beams used therein.

5 - 2 ~ 3 ~
BRIEF DESCRIPTION OF THE DRAWINGS
The invention is herein described, by way of example only, with reference to the accompanying drawings, wherein:
FIG. 1 is a graph of the extinction length, in water, of light of 5 various wavelengths, vs. wavelength;
FIG. 2A shows the firing schedule of the lasers in one embodiment of the present invention;
FIG. 2B shows the combined laser output corresponding to figure 2A;
FIG. 2C shows the combined laser output corresponding to the firing schedule of a different embodiment of the present invention.

DESCRIPTION OF THE PREFERRED EMBODIMENTS
The present invention is of a method for delicate laser surgery.
Specifically, the present invention can be used for precision skin 15 resurfacing and hair irnplantation. Although these specific procedures most commonly are performed on hllm~n patients, it will be appreciated by those ordinarily skilled in the art that the method described herein is equally applicable to surgical procedures carried out on lower m~mm~
The principles of precision laser surgery according to the present 20 invention may be better understood with reference to the drawings and the accompanying description.

6 ~ 3 ~
Referring now to the drawings, Figure 1 is a graph of the extinction length in water of infrared radiation of various wavelengths. Because skin tissue is 77% water by weight, water can be used as a proxy for skin tissue in selecting wavelengths for surgery.
To minimi7e peripheral damage, the extinction length of coherent radiation used for ablative cutting should be as small as posslble.
According to Figure 1, this length is between 0.01 millimeters and 0.001 millimeters. Note that the corresponding range of wavelengths is between about 2.5 microns and about 3.2 microns. This range is substantially 10 narrower than the 2-12 micron range recommended by Freiberg for ablative cutting. The 2.94 micron radiation of an erbium YAG laser has an extinction length in this range. The thermal relaxation time of m~mm~ n skin tissue is approxirnately one millisecond. Thus, the laser pulse duration should be no longer than this, and preferably about 0.3 15 milliseconds. The energy density of each pulse preferably is between one Joule per square centimeter and 50 Joules per square centimeter.
The extinction length of coherent radiation used for coagulation of small blood vessels should be somewhat longer than the extinction length of coherent radiation used for ablation, to spread the heating effect of the 20 laser beam over a larger depth range than is used for ablation. The intent here is merely to coagulate the blood, not to vaporize it. Between 0.1 millimeters and 0.01 millimeters is an appropliate extinction length for 3 ~

coagulation. The 10.6 micron radiation of a carbon dioxide laser has an extinction length in this range.
The laser beam used for coagulation may be either continuous or pulsed, as long as the duration of the coagulation beam substantially S overlaps the duration of the ablation bearn, as shown in Figures 2A, 2B, and 2C. In the four plots shown in these Figures, time T is the abscissa and beam intensity E is the ordinate. Figure 2A shows separate firing schedules for an erbium YAG ablation laser and a carbon dioxide coagulation laser in a preferred embodirnent of the present invention in 10 which the carbon dioxide laser is a continuous wave laser. The erbium YAG laser emits periodic pulses. The carbon dioxide laser fires continuously. The total laser output is the superposition of these t~vo outputs, as shown in Figure 2B. Preferably, the power level of the carbon dioxide laser is sufficiently high to coagulate the blood vessels cut by the 15 erbium YAG laser in between pulses of the erbium YAG laser, but not sufficiently high to cause peripheral damage by unwanted ablation. The preferred power density for a continuous wave carbon dioxide laser is between one Watt per square centimeter and 10 Watts per square centimeter.
Figure 2C shows the combined output of the erbium YAG laser and the carbon dioxide laser in a preferred embodiment of the present invention in which both lasers are pulsed. Note that the duration of each 8 ~ 3 ~
carbon dioxide laser pulse overlaps, and extends substantially beyond, the duration of the corresponding erbillm YAG laser pulse. Again, the object here is to coagulate the blood vessels cut by the erbium YAG laser without causing peripheral damage by unwanted ablation. The preferred carbon 5 dioxide pulse duration is between one millisecond and 10 milliseconds, and the preferred power density is between one Watt per square centimeter and 100 Watts per square centimeter.
The extinction length of coherent radiation used to shrirlk collagen preferably should match the thickness of the target collagen layer, which 10 may be as thick as about one millimeter. Collagen thinner than about 0.1 millimeters is shrunk by a laser appropriate for coagulation, for example a carbon dioxide laser. Thicker collagen is shrunk by a laser whose radiation has an extinction length of between about one millimeter and 0.1 millimeters. The 2.12 micron radiation of a holmium YAG laser has an 15 extinction length in this range. The shrinkage laser beam may be continuous or pulsed. Preferred pulse durations for a holmium YAG laser used to shrink collagen are between 0.3 milliseconds and one millisecond, and the preferred pulse energy density is about one Joule per square centimeter.
The range of wavelengths useful for laser surgery, as shown in Figure 1, is in the invisible infrared. In preferred embodiments of the present invention, a third, low power beam of visible coherent radiation 9 ~ 3 ~
is directed coaxially with the other two beams, so that the surgeon can see where the beams strike the patient.
While the invention has been described with respect to a limite~l number of embodiments, it will be appreciated that many variations, S modifications and other applications of the invention may be made.

Claims (22)

1. A method for surgical alteration of skin tissue by simultaneous ablation and coagulation, comprising the steps of:
(a) selecting a first coherent radiation source characterized by emitting a first coherent radiation having an extinction length in the skin tissue of between about 0.01 millimeters and about 0.001 millimeters;
(b) selecting a second coherent radiation source characterized by emitting a second coherent radiation having an extinction length in the skin tissue of between about 0.1 millimeters and about 0.01 millimeters;
(c) ablating the skin tissue by directing a first beam of said first coherent radiation at the skin tissue; and (d) coagulating the skin tissue by directing a second beam of said second coherent radiation at the skin tissue, substantially coaxially and substantially simultaneously with said first beam.
2. The method of claim 1, wherein said first coherent radiation source is a laser.
3. The method of claim 2, wherein said first coherent radiation source is an erbium YAG laser.
4. The method of claim 1, wherein said second coherent radiation source is a laser.
5. The method of claim 4, wherein said laser is a carbon dioxide laser.
6. The method of claim 1, wherein said first beam is pulsed.
7. The method of claim 6, wherein each of said pulses has a duration of about 0.3 milliseconds, and wherein each of said pulses has an energy density of between about one Joule per square centimeter and about 50 Joules per square centimeter.
8. The method of claim 6, wherein said second beam is continuous.
9. The method of claim 8, wherein said second beam has a power density of between about one Watt per square centimeter and about
10 Watts per square centimeter.

10. The method of claim 6, wherein said second beam is pulsed, said pulses of said second beam at least partially overlapping in time with said pulses of said first beam.
11. The method of claim 10, wherein each of said pulses of said second beam has a duration of between about one millisecond and about 10 milliseconds, and wherein each of said pulses of said second beam has a power density of between about one Watt per square centimeter and about 100 Watts per square centimeter.
12. The method of claim 1, further comprising the step of directing a third beam of visible coherent radiation at the skin tissue, substantially coaxially and substantially simultaneously with said first beam.
13. A method for surgical alteration of skin tissue by simultaneous ablation and shrinkage, comprising the steps of:
(a) selecting a first coherent radiation source characterized by emitting a first coherent radiation having an extinction length in the skin tissue of between about 0.01 millimeters and about 0.001 millimeters;

(b) selecting a second coherent radiation source characterized by emitting a second coherent radiation having an extinction length in the skin tissue of between about one millimeter and about 0.01 millimeters;
(c) ablating the skin tissue by directing a first beam of said first coherent radiation at the skin tissue; and (d) shrinking the skin tissue by directing a second beam of said second coherent radiation at the skin tissue, substantially coaxially and substantially simultaneously with said first beam.
14. The method of claim 13, wherein said first coherent radiation source is a laser.
15. The method of claim 14, wherein said first coherent radiation source is an erbium YAG laser.
16. The method of claim 13, wherein said second coherent radiation source is a laser.
17. The method of claim 16, wherein said laser is a holmium YAG laser.
18. The method of claim 13, wherein said first beam is pulsed.
19. The method of claim 18, wherein each of said pulses has a duration of about 0.3 milliseconds, and wherein each of said pulses has an energy density of between about one Joule per square centimeter and about 50 Joules per square centimeter.
20. The method of claim 18, wherein said second beam is pulsed, said pulses of said second beam at least partially overlapping in time with said pulses of said first beam.
21. The method of claim 20, wherein each of said pulses of said second beam has a duration of between about 0.3 milliseconds and about one millisecond, and wherein each of said pulses of said second beam has an energy density of about one Joule per square centimeter.
22. The method of claim 13, further comprising the step of directing a third beam of visible coherent radiation at the skin tissue, substantially coaxially and substantially simultaneously with said first beam.
CA002201836A 1996-05-15 1997-04-04 Method for laser surgery Abandoned CA2201836A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/647,531 1996-05-15
US08/647,531 US5655547A (en) 1996-05-15 1996-05-15 Method for laser surgery

Publications (1)

Publication Number Publication Date
CA2201836A1 true CA2201836A1 (en) 1997-11-15

Family

ID=24597335

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002201836A Abandoned CA2201836A1 (en) 1996-05-15 1997-04-04 Method for laser surgery

Country Status (7)

Country Link
US (1) US5655547A (en)
EP (1) EP0807418A3 (en)
JP (1) JPH1043196A (en)
KR (1) KR970073528A (en)
AU (1) AU1995297A (en)
CA (1) CA2201836A1 (en)
IL (1) IL120528A0 (en)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5993439A (en) * 1994-08-29 1999-11-30 Cell Robotics, Inc. Lens shield for laser skin perforation
US5554153A (en) * 1994-08-29 1996-09-10 Cell Robotics, Inc. Laser skin perforator
US7267675B2 (en) 1996-01-05 2007-09-11 Thermage, Inc. RF device with thermo-electric cooler
US7229436B2 (en) 1996-01-05 2007-06-12 Thermage, Inc. Method and kit for treatment of tissue
US7189230B2 (en) * 1996-01-05 2007-03-13 Thermage, Inc. Method for treating skin and underlying tissue
US7452358B2 (en) * 1996-01-05 2008-11-18 Thermage, Inc. RF electrode assembly for handpiece
US7115123B2 (en) 1996-01-05 2006-10-03 Thermage, Inc. Handpiece with electrode and non-volatile memory
US7022121B2 (en) 1999-03-09 2006-04-04 Thermage, Inc. Handpiece for treatment of tissue
US7006874B2 (en) 1996-01-05 2006-02-28 Thermage, Inc. Treatment apparatus with electromagnetic energy delivery device and non-volatile memory
US6350276B1 (en) 1996-01-05 2002-02-26 Thermage, Inc. Tissue remodeling apparatus containing cooling fluid
US5970983A (en) * 1996-05-15 1999-10-26 Esc Medical Systems Ltd. Method of laser surgery
US6517532B1 (en) 1997-05-15 2003-02-11 Palomar Medical Technologies, Inc. Light energy delivery head
US8182473B2 (en) 1999-01-08 2012-05-22 Palomar Medical Technologies Cooling system for a photocosmetic device
US6653618B2 (en) 2000-04-28 2003-11-25 Palomar Medical Technologies, Inc. Contact detecting method and apparatus for an optical radiation handpiece
US7204832B2 (en) 1996-12-02 2007-04-17 Pálomar Medical Technologies, Inc. Cooling system for a photo cosmetic device
US6248102B1 (en) 1997-04-04 2001-06-19 Keralase Ltd. Method of hair removal by transcutaneous application of laser light
JP4056091B2 (en) 1997-05-15 2008-03-05 パロマー・メディカル・テクノロジーズ・インコーポレーテッド Dermatological treatment method and apparatus
EP0885629A3 (en) 1997-06-16 1999-07-21 Danish Dermatologic Development A/S Light pulse generating apparatus and cosmetic and therapeutic phototreatment
US6165170A (en) * 1998-01-29 2000-12-26 International Business Machines Corporation Laser dermablator and dermablation
US20010016732A1 (en) * 1998-02-03 2001-08-23 James L. Hobart Dual mode laser delivery system providing controllable depth of tissue ablation and corresponding controllable depth of coagulation
US6575964B1 (en) 1998-02-03 2003-06-10 Sciton, Inc. Selective aperture for laser delivery system for providing incision, tissue ablation and coagulation
WO1999046005A1 (en) 1998-03-12 1999-09-16 Palomar Medical Technologies, Inc. System for electromagnetic radiation of the skin
US6605080B1 (en) 1998-03-27 2003-08-12 The General Hospital Corporation Method and apparatus for the selective targeting of lipid-rich tissues
CA2331113A1 (en) * 1998-04-30 1999-11-04 Esc Medical Systems Ltd. Surgical alteration of skin tissue
US7494488B2 (en) * 1998-05-28 2009-02-24 Pearl Technology Holdings, Llc Facial tissue strengthening and tightening device and methods
US6203540B1 (en) * 1998-05-28 2001-03-20 Pearl I, Llc Ultrasound and laser face-lift and bulbous lysing device
US6059820A (en) 1998-10-16 2000-05-09 Paradigm Medical Corporation Tissue cooling rod for laser surgery
US6514242B1 (en) * 1998-12-03 2003-02-04 David Vasily Method and apparatus for laser removal of hair
US6208673B1 (en) 1999-02-23 2001-03-27 Aculight Corporation Multifunction solid state laser system
AUPQ339699A0 (en) * 1999-10-13 1999-11-04 Lions Eye Institute Of Western Australia Incorporated, The Method of enhanced biological material removal using short pulse lasers
US6888319B2 (en) 2001-03-01 2005-05-03 Palomar Medical Technologies, Inc. Flashlamp drive circuit
US6605079B2 (en) 2001-03-02 2003-08-12 Erchonia Patent Holdings, Llc Method for performing lipoplasty using external laser radiation
US8083785B2 (en) * 2001-03-02 2011-12-27 Erchonia Corporation Multi-probe laser device
US20060229690A1 (en) * 2001-03-02 2006-10-12 Shanks Steven C Device that emits laser beams at automatically-changing pulse frequencies
US6746473B2 (en) 2001-03-02 2004-06-08 Erchonia Patent Holdings, Llc Therapeutic laser device
US6743221B1 (en) 2001-03-13 2004-06-01 James L. Hobart Laser system and method for treatment of biological tissues
US6770069B1 (en) 2001-06-22 2004-08-03 Sciton, Inc. Laser applicator
WO2003003903A2 (en) 2001-07-02 2003-01-16 Palomar Medical Technologies, Inc. Laser device for medical/cosmetic procedures
EP1627662B1 (en) * 2004-06-10 2011-03-02 Candela Corporation Apparatus for vacuum-assisted light-based treatments of the skin
ATE425713T1 (en) * 2001-12-10 2009-04-15 Inolase 2002 Ltd DEVICE FOR EXTRACTING AIR AND CONDENSED STEAM FROM NEAR A SKIN TARGET AREA
US7935139B2 (en) * 2001-12-10 2011-05-03 Candela Corporation Eye safe dermatological phototherapy
US7762964B2 (en) * 2001-12-10 2010-07-27 Candela Corporation Method and apparatus for improving safety during exposure to a monochromatic light source
US7762965B2 (en) * 2001-12-10 2010-07-27 Candela Corporation Method and apparatus for vacuum-assisted light-based treatments of the skin
US20030109860A1 (en) * 2001-12-12 2003-06-12 Michael Black Multiple laser treatment
US20030216719A1 (en) * 2001-12-12 2003-11-20 Len Debenedictis Method and apparatus for treating skin using patterns of optical energy
US20040082940A1 (en) * 2002-10-22 2004-04-29 Michael Black Dermatological apparatus and method
US20030109787A1 (en) * 2001-12-12 2003-06-12 Michael Black Multiple laser diagnostics
US7540869B2 (en) 2001-12-27 2009-06-02 Palomar Medical Technologies, Inc. Method and apparatus for improved vascular related treatment
CN1652729A (en) * 2002-03-12 2005-08-10 帕洛玛医疗技术公司 Method and apparatus for hair growth management
US20070213698A1 (en) * 2006-03-10 2007-09-13 Palomar Medical Technologies, Inc. Photocosmetic device
US7135033B2 (en) 2002-05-23 2006-11-14 Palomar Medical Technologies, Inc. Phototreatment device for use with coolants and topical substances
JP2006500972A (en) 2002-06-19 2006-01-12 パロマー・メディカル・テクノロジーズ・インコーポレイテッド Method and apparatus for treating tissue at a depth by radiant heat
JP2005535370A (en) 2002-06-19 2005-11-24 パロマー・メディカル・テクノロジーズ・インコーポレイテッド Method and apparatus for treating skin and subcutaneous conditions
US7740600B2 (en) * 2002-08-02 2010-06-22 Candela Corporation Apparatus and method for inhibiting pain signals transmitted during a skin related medical treatment
KR100508979B1 (en) * 2002-09-27 2005-08-17 주식회사 솔고 바이오메디칼 Erbium yag laser apparatus
KR20050062597A (en) * 2002-10-07 2005-06-23 팔로마 메디칼 테크놀로지스, 인코포레이티드 Apparatus for performing photobiostimulation
US20070179481A1 (en) * 2003-02-14 2007-08-02 Reliant Technologies, Inc. Laser System for Treatment of Skin Laxity
AU2004226378A1 (en) 2003-03-27 2004-10-14 The General Hospital Corporation Method and apparatus for dermatological treatment and fractional skin resurfacing
US7220254B2 (en) 2003-12-31 2007-05-22 Palomar Medical Technologies, Inc. Dermatological treatment with visualization
US7824394B2 (en) 2004-04-01 2010-11-02 The General Hospital Corporation Method and apparatus for dermatological treatment and tissue reshaping
WO2005107867A2 (en) * 2004-04-30 2005-11-17 Led Healing Light, Llc Hand held pulse laser for therapeutic use
US7413572B2 (en) 2004-06-14 2008-08-19 Reliant Technologies, Inc. Adaptive control of optical pulses for laser medicine
US7856985B2 (en) 2005-04-22 2010-12-28 Cynosure, Inc. Method of treatment body tissue using a non-uniform laser beam
CN101309631A (en) 2005-09-15 2008-11-19 帕洛玛医疗技术公司 Skin optical characterization device
US20070212335A1 (en) * 2006-03-07 2007-09-13 Hantash Basil M Treatment of alopecia by micropore delivery of stem cells
US20070264626A1 (en) * 2006-05-11 2007-11-15 Reliant Technologies, Inc. Apparatus and Method for a Combination of Ablative and Nonablative Dermatological Treatment
US20070264625A1 (en) * 2006-05-11 2007-11-15 Reliant Technologies, Inc. Apparatus and Method for Ablation-Related Dermatological Treatment of Selected Targets
US7586957B2 (en) 2006-08-02 2009-09-08 Cynosure, Inc Picosecond laser apparatus and methods for its operation and use
US7826977B2 (en) * 2006-08-25 2010-11-02 The Trustees Of Columbia University In The City Of New York Systems and methods for high-speed image scanning
US8257347B2 (en) * 2006-09-12 2012-09-04 Biolitec Pharma Marketing Ltd. Vein treatment device and method
US7740651B2 (en) * 2007-09-28 2010-06-22 Candela Corporation Vacuum assisted treatment of the skin
JP2011509791A (en) * 2008-01-24 2011-03-31 シネロン メディカル リミテッド Apparatus, device and method for adipose tissue treatment
US9044255B2 (en) 2009-03-27 2015-06-02 Ams Research Corporation Laser modulation for coagulation
US9919168B2 (en) 2009-07-23 2018-03-20 Palomar Medical Technologies, Inc. Method for improvement of cellulite appearance
JP5774001B2 (en) 2009-07-27 2015-09-02 ノヴォクセル リミテッド Method and apparatus for tissue ablation
DK2608762T4 (en) 2010-08-27 2020-07-20 Sienna Biopharmaceuticals Inc COMPOSITIONS AND METHODS FOR TARGETED HEAT MODULATION
US9572880B2 (en) 2010-08-27 2017-02-21 Sienna Biopharmaceuticals, Inc. Ultrasound delivery of nanoparticles
KR102183581B1 (en) 2012-04-18 2020-11-27 싸이노슈어, 엘엘씨 Picosecond laser apparatus and methods for treating target tissues with same
RU2646809C2 (en) 2012-10-11 2018-03-07 Нанокомпозикс, Инк. Silver nanoplates compositions and methods
WO2014145707A2 (en) 2013-03-15 2014-09-18 Cynosure, Inc. Picosecond optical radiation systems and methods of use
EP3957262A1 (en) 2013-12-18 2022-02-23 Novoxel Ltd. Devices for tissue vaporization
US20170071695A1 (en) * 2014-01-10 2017-03-16 Riken Medical laser light source system
EP3091927A4 (en) * 2014-01-10 2017-09-27 Sebacia, Inc. Sub-surface array of absorber materials, and light irradiation therapy
CN106999237B (en) 2014-09-15 2020-06-12 诺服塞尔有限公司 Method and apparatus for thermal tissue vaporization and compression
US9220563B1 (en) 2014-12-29 2015-12-29 InnovaQuartz LLC Multiwavelength surgical laser
US10893899B2 (en) 2016-03-26 2021-01-19 Paul Weber Apparatus and systems for minimally invasive dissection of tissues
US11510730B2 (en) 2016-03-26 2022-11-29 Paul Joseph Weber Apparatus and methods for minimally invasive dissection and modification of tissues
US10603101B2 (en) 2016-03-26 2020-03-31 Paul Joseph Weber Apparatus, systems and methods for minimally invasive dissection of tissues
CN112042066A (en) 2018-02-26 2020-12-04 赛诺秀股份有限公司 Q-switched cavity-tilting subnanosecond laser
US20210305763A1 (en) * 2020-03-24 2021-09-30 David Stucker Composite fiber laser assembly

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3710798A (en) * 1971-08-30 1973-01-16 American Optical Corp Laser system for microsurgery
US4408602A (en) * 1981-01-14 1983-10-11 Asahi Kogaku Kogyo Kabushiki Kaisha Laser knife device
JPS5821387A (en) * 1981-07-29 1983-02-08 Olympus Optical Co Ltd Irradiator for laser
US4520816A (en) * 1983-01-12 1985-06-04 Schachar Ronald A Method and apparatus for delivering laser energy for ophthalmic use
US4503854A (en) * 1983-06-16 1985-03-12 Jako Geza J Laser surgery
GB8808762D0 (en) * 1988-04-13 1988-05-18 Southampton University Glass laser operating in visible region
EP0368512A3 (en) * 1988-11-10 1990-08-08 Premier Laser Systems, Inc. Multiwavelength medical laser system
US5066291A (en) * 1990-04-25 1991-11-19 Cincinnati Sub-Zero Products, Inc. Solid-state laser frequency conversion system
US5217455A (en) * 1991-08-12 1993-06-08 Tan Oon T Laser treatment method for removing pigmentations, lesions, and abnormalities from the skin of a living human
US5290274A (en) * 1992-06-16 1994-03-01 Laser Medical Technology, Inc. Laser apparatus for medical and dental treatments
US5387211B1 (en) * 1993-03-10 1996-12-31 Trimedyne Inc Multi-head laser assembly
US5304170A (en) * 1993-03-12 1994-04-19 Green Howard A Method of laser-induced tissue necrosis in carotenoid-containing skin structures

Also Published As

Publication number Publication date
EP0807418A2 (en) 1997-11-19
AU1995297A (en) 1997-11-20
IL120528A0 (en) 1997-07-13
EP0807418A3 (en) 1998-01-07
KR970073528A (en) 1997-12-10
JPH1043196A (en) 1998-02-17
US5655547A (en) 1997-08-12

Similar Documents

Publication Publication Date Title
US5655547A (en) Method for laser surgery
US5970983A (en) Method of laser surgery
US6083217A (en) Destruction for unwanted tissue by deep laser heating of water
US5897549A (en) Transformation of unwanted tissue by deep laser heating of water
US4925523A (en) Enhancement of ultraviolet laser ablation and etching organic solids
DK2838613T3 (en) Medical system for the treatment of deep tissue targets
US6235015B1 (en) Method and apparatus for selective hair depilation using a scanned beam of light at 600 to 1000 nm
US5931834A (en) Method for non-synchronous laser-assisted myocardial revascularization
Peavy Lasers and laser–tissue interaction
EP2578175A2 (en) Method and apparatus for producing thermal damage within the skin
US20080287930A1 (en) Thermal Energy Applicator
US7635362B2 (en) Method and apparatus treating area of the skin by using multipulse laser
US20020019624A1 (en) Depilation
KR20000005305A (en) Alexandrite laser system for treatment of dermatological specimens
CA2326120A1 (en) Method and apparatus for the selective targeting of lipid-rich tissues
Ohshiro et al. Laser applications in plastic and reconstructive surgery
Calderhead Photobiological basics of photomedicine: a work of art still in progress
CA1332445C (en) Microsurgery using alternating laser beams of different wave lengths
EA004277B1 (en) Method for laser coagulating blood vessels
US6267755B1 (en) Method of hair depilation
Waner Lasers in facial plastic and reconstructive surgery
Lanigan Therapeutic Applications: Dermatology—Selective Photothermolysis
Absten et al. Laser-tissue interactions
Neev et al. Thermo-optical skin conditioning: a new method for thermally modifying skin conditions
Verdaasdonck et al. Characterization of handpieces to control tissue ablation with pulsed CO2 laser

Legal Events

Date Code Title Description
FZDE Discontinued