CA2208420A1 - Methods and compositions for inhibition of membrane fusion-associated events, including hiv transmission - Google Patents
Methods and compositions for inhibition of membrane fusion-associated events, including hiv transmissionInfo
- Publication number
- CA2208420A1 CA2208420A1 CA002208420A CA2208420A CA2208420A1 CA 2208420 A1 CA2208420 A1 CA 2208420A1 CA 002208420 A CA002208420 A CA 002208420A CA 2208420 A CA2208420 A CA 2208420A CA 2208420 A1 CA2208420 A1 CA 2208420A1
- Authority
- CA
- Canada
- Prior art keywords
- virus
- peptide
- hiv
- inhibition
- compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000005540 biological transmission Effects 0.000 title claims abstract 3
- 230000005764 inhibitory process Effects 0.000 title claims 2
- 230000034217 membrane fusion Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract 15
- 241000700605 Viruses Species 0.000 claims 17
- 208000031886 HIV Infections Diseases 0.000 claims 2
- 241000700721 Hepatitis B virus Species 0.000 claims 2
- 241000701044 Human gammaherpesvirus 4 Species 0.000 claims 2
- 241000713772 Human immunodeficiency virus 1 Species 0.000 claims 2
- 241000713340 Human immunodeficiency virus 2 Species 0.000 claims 2
- 208000002606 Paramyxoviridae Infections Diseases 0.000 claims 2
- 241000725643 Respiratory syncytial virus Species 0.000 claims 2
- 241000712461 unidentified influenza virus Species 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000000798 anti-retroviral effect Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000001177 retroviral effect Effects 0.000 abstract 1
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Abstract
The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP178 (SEQ ID:1) peptide corresponding to amino acids 638 to 673 of the HIV-1LAI
gp4l protein, and fragments, analogs and homologs of DP178.
The invention further relates to the uses of such peptides as inhibitory of human and non-human retroviral, especially HIV, transmission to uninfected cells.
gp4l protein, and fragments, analogs and homologs of DP178.
The invention further relates to the uses of such peptides as inhibitory of human and non-human retroviral, especially HIV, transmission to uninfected cells.
Claims (15)
1. An isolated peptide recognized by an ALLMOTI5, 107x178x4 or a PLZIP sequence search motif.
2. The peptide of Claim 1 wherein the peptide corresponds to a peptide present in a virus.
3. The peptide of Claim 2 in which the virus is HIV-1 or HIV-2.
4. The peptide of Claim 2 in which the virus is a respiratory syncytial virus.
5. The peptide of Claim 2 in which the virus is a human parainfluenza virus.
6. The peptide of Claim 2 in which the virus is an influenza virus.
7. The peptide of Claim 2 in which the virus is a hepatitis B virus.
8. The peptide of Claim 2 wherein the virus is an Epstein-Barr virus.
9. A method for the inhibition of transmission of a virus to a cell, comprising contacting the cell with an effective concentration of a peptide recognized by an ALLMOTI5, 107x178x4 or a PLZIP
sequence search motif for an effective period of time so that no infection of the cell by the virus occurs.
sequence search motif for an effective period of time so that no infection of the cell by the virus occurs.
10. The method of Claim 9 wherein the virus is HIV-1 or HIV-2.
11. The method of Claim 9 wherein the virus is a respiratory syncytial virus.
12. The method of Claim 9 wherein the virus is a human parainfluenza virus.
13. The method of Claim 9 wherein the virus is an influenza virus.
14. The method of Claim 9 in which the virus is a hepatitis B virus.
15. The method of Claim 9 wherein the virus is an Epstein-Barr virus.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/360,107 US6017536A (en) | 1993-06-07 | 1994-12-20 | Simian immunodeficiency virus peptides with antifusogenic and antiviral activities |
US360,107 | 1994-12-20 | ||
US470,896 | 1995-06-06 | ||
US08/470,896 US6479055B1 (en) | 1993-06-07 | 1995-06-06 | Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission |
PCT/US1995/016733 WO1996019495A1 (en) | 1994-12-20 | 1995-12-20 | Methods and compositions for inhibition of membrane fusion-associated events, including hiv transmission |
Publications (2)
Publication Number | Publication Date |
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CA2208420A1 true CA2208420A1 (en) | 1996-06-27 |
CA2208420C CA2208420C (en) | 2010-11-09 |
Family
ID=27000760
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CA2208420A Expired - Lifetime CA2208420C (en) | 1994-12-20 | 1995-12-20 | Methods and compositions for inhibition of membrane fusion-associated events, including hiv transmission |
Country Status (10)
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US (17) | US6479055B1 (en) |
EP (2) | EP1714974A3 (en) |
JP (3) | JP2001523082A (en) |
KR (1) | KR100558087B1 (en) |
AT (1) | ATE308558T1 (en) |
CA (1) | CA2208420C (en) |
DE (1) | DE69534569T2 (en) |
ES (1) | ES2252747T3 (en) |
NZ (1) | NZ300002A (en) |
WO (1) | WO1996019495A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014159813A1 (en) | 2013-03-13 | 2014-10-02 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
Families Citing this family (120)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070202127A1 (en) * | 1993-06-07 | 2007-08-30 | Duke University | Nucleic acids encoding DP-178 and other viral fusion inhibitor peptides useful for treating aids |
US6479055B1 (en) * | 1993-06-07 | 2002-11-12 | Trimeris, Inc. | Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission |
WO1996040191A1 (en) * | 1995-06-07 | 1996-12-19 | Trimeris, Inc. | The treatment of hiv and other viral infections using combinatory therapy |
US6271198B1 (en) | 1996-11-06 | 2001-08-07 | Genentech, Inc. | Constrained helical peptides and methods of making same |
FR2771011B1 (en) * | 1997-11-17 | 2000-01-28 | Hippocampe | OBTAINING VACCINES TO PREVENT PATHOGENIC EFFECTS ASSOCIATED WITH RETROVIRAL INFECTION |
NZ507083A (en) * | 1998-03-23 | 2003-10-31 | Trimeris Inc | Methods and compositions for peptide synthesis, in particular T-20 (DP-178) and T-20-like peptides |
US6281331B1 (en) | 1998-03-23 | 2001-08-28 | Trimeris, Inc. | Methods and compositions for peptide synthesis |
NZ532665A (en) | 1998-05-01 | 2005-11-25 | Inst Genomic Research | Neisseria meningitidis antigens and compositions |
US20070026021A1 (en) * | 1998-05-01 | 2007-02-01 | Chiron S.R.I. | Neisseria meningitidis antigens and compositions |
US6656906B1 (en) | 1998-05-20 | 2003-12-02 | Trimeris, Inc. | Hybrid polypeptides with enhanced pharmacokinetic properties |
US6258782B1 (en) | 1998-05-20 | 2001-07-10 | Trimeris, Inc. | Hybrid polypeptides with enhanced pharmacokinetic properties |
US6797462B1 (en) | 1998-06-23 | 2004-09-28 | Uab Research Foundation | Cell-based assay for immunodeficiency virus infectivity and sensitivity |
FR2786773B1 (en) * | 1998-12-03 | 2002-03-08 | Univ Paris Curie | ENVELOPE PROTEINS, METHODS AND USES |
WO2000045833A1 (en) * | 1999-02-02 | 2000-08-10 | Uab Research Foundation, The | Hiv drug resistance system |
EP1181304B1 (en) | 1999-04-08 | 2007-10-10 | Antisoma Research Limited | Antiproliferative activity of g-righ oligonucleotides and method of using same to bind to nucleolin |
US7960540B2 (en) | 1999-04-08 | 2011-06-14 | Advanced Cancer Therapeutics, Llc | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
US20080318889A1 (en) * | 1999-04-08 | 2008-12-25 | Antisoma Research Limited | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
US8114850B2 (en) | 1999-04-08 | 2012-02-14 | Advanced Cancer Therapeutics, Llc | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
US20080318890A1 (en) * | 1999-04-08 | 2008-12-25 | Antisoma Research Limited | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
JP4520441B2 (en) * | 1999-05-13 | 2010-08-04 | 独立行政法人科学技術振興機構 | Viral infection inhibitor targeting integrase N-terminal region |
ATE443714T1 (en) * | 1999-05-17 | 2009-10-15 | Conjuchem Biotechnologies Inc | LONG-ACTING PEPTIDE INHIBITORS OF VIRUS FUSION WITH BODY CELLS IN VIRAL INFECTIONS |
US6469136B1 (en) | 1999-07-07 | 2002-10-22 | Trimeris, Inc. | Methods and composition for peptide synthesis |
US6541020B1 (en) | 1999-07-09 | 2003-04-01 | Trimeris, Inc. | Methods and compositions for administration of therapeutic reagents |
SK782002A3 (en) | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
US6706892B1 (en) | 1999-09-07 | 2004-03-16 | Conjuchem, Inc. | Pulmonary delivery for bioconjugation |
US7090851B1 (en) | 1999-09-10 | 2006-08-15 | Conjuchem Inc. | Long lasting fusion peptide inhibitors of viral infection |
WO2001024764A2 (en) * | 1999-10-06 | 2001-04-12 | The Trustees Of The University Of Pennsylvania | Cell targeting compositions and methods of using the same |
AU3334001A (en) | 2000-02-10 | 2001-08-20 | Panacos Pharmaceuticals Inc | Assay for detection of viral fusion inhibitors |
US6623741B1 (en) * | 2000-02-29 | 2003-09-23 | Trimeris, Inc. | Methods and compositions for inhibition of membrane fusion-associated events including RSV transmission |
US6528308B1 (en) | 2000-03-16 | 2003-03-04 | Duke University | Suppressor of HIV replication and transcription |
EP2141244A1 (en) * | 2000-10-18 | 2010-01-06 | Pharmasset, Inc. | Multiplex quantification of nucleic acids in diseased cells |
BR0115728A (en) * | 2000-11-28 | 2003-09-23 | Wyeth Corp | Analysis of expression of kiaa nucleic acids and polypeptides useful in the diagnosis and treatment of prostate cancer. |
NZ526708A (en) * | 2000-11-28 | 2005-07-29 | Wyeth Corp | Expression analysis of FKBP nucleic acids and polypeptides useful in the diagnosis and treatment of prostate cancer |
US20020142327A1 (en) * | 2000-11-28 | 2002-10-03 | Gillis Kimberly A. | Expression analysis of smarc nucleic acids and polypeptides useful in the diagnosis and treatment of prostate cancer |
DE60216151T2 (en) * | 2001-05-31 | 2007-09-27 | ConjuChem Biotechnologies Inc., Montreal | Long acting fusion peptide inhibitors against HIV infection |
CN1255548C (en) | 2001-06-15 | 2006-05-10 | 霍夫曼-拉罗奇有限公司 | Acetylation of GP41 framgnets |
US7176278B2 (en) | 2001-08-30 | 2007-02-13 | Biorexis Technology, Inc. | Modified transferrin fusion proteins |
US20050227933A1 (en) * | 2001-11-29 | 2005-10-13 | Benkovic Stephen J | Treatment of bacterial induced diseases using DNA methyl transferase inhibitors |
EP2258712A3 (en) * | 2002-03-15 | 2011-05-04 | Multicell Immunotherapeutics, Inc. | Compositions and Methods to Initiate or Enhance Antibody and Major-histocompatibility Class I or Class II-restricted T Cell Responses by Using Immunomodulatory, Non-coding RNA Motifs |
WO2004035808A2 (en) * | 2002-10-16 | 2004-04-29 | Panacos Pharmaceuticals, Inc. | Method for detecting viral inactivating agents |
CA2443365C (en) * | 2002-11-19 | 2010-01-12 | F. Hoffmann-La Roche Ag | Methods for the recombinant production of antifusogenic peptides |
NZ567952A (en) * | 2003-03-24 | 2009-12-24 | Sequoia Pharmaceuticals Inc | Long acting biologically active conjugates |
AU2004225480A1 (en) * | 2003-03-26 | 2004-10-14 | Multicell Immunotherapeutics, Inc. | Selected RNA motifs to include cell death and/or apoptosis |
WO2004108885A2 (en) * | 2003-05-06 | 2004-12-16 | Syntonix Pharmaceuticals, Inc. | Fc chimeric proteins with anti-hiv drugs |
TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
US7348004B2 (en) | 2003-05-06 | 2008-03-25 | Syntonix Pharmaceuticals, Inc. | Immunoglobulin chimeric monomer-dimer hybrids |
SI2298347T1 (en) * | 2003-05-06 | 2016-03-31 | Biogen Hemophilia Inc. | Clotting factor chimeric proteins for treatment of a hemostatic disorder |
EP1624846A2 (en) * | 2003-05-06 | 2006-02-15 | Syntonix Pharmaceuticals, Inc. | Inhibition of drug binding to serum albumin |
EP1718321A4 (en) * | 2003-05-08 | 2009-09-23 | Porter W Anderson | Anti-hiv-1 compounds based upon a conserved amino acid sequence shared by gp160 and the human cd4 protein |
JP2007524649A (en) * | 2003-07-29 | 2007-08-30 | イミューノメディクス、インコーポレイテッド | Fluorinated carbohydrate complex |
US20050214318A1 (en) * | 2003-10-23 | 2005-09-29 | Nmk Research, Llc | Immunogenic composition and method of developing a vaccine based on fusion protein |
US20110104196A1 (en) * | 2003-10-23 | 2011-05-05 | Karp Nelson M | Immunogenic composition and method of developing a vaccine based on fusion protein |
EP2261375B1 (en) * | 2003-11-04 | 2013-01-23 | The Administrators of the Tulane Educational Fund | Method of preventing virus:cell fusion by inhibiting the function of the fusion initiation region in RNA viruses having class I membrane fusogenic envelope proteins |
EP2161027A3 (en) | 2003-12-22 | 2010-04-28 | Yeda Research And Development Co., Ltd. | Diastereomeric peptides useful as inhibitors of membrane protein assembly |
CA2548181A1 (en) | 2003-12-23 | 2005-07-14 | Centocor, Inc. | Anti-retroviral agents, compositions, methods and uses |
CA2550455C (en) | 2003-12-23 | 2017-01-03 | Children's Hospital, Inc. | Haemophilus influenzae type iv pili |
EP1701971A2 (en) * | 2003-12-31 | 2006-09-20 | F.Hoffmann-La Roche Ag | Peptide synthesis using decanting filter |
DE602004009710T2 (en) * | 2003-12-31 | 2008-08-07 | F. Hoffmann-La Roche Ag | METHOD OF PEPTIDE SYNTHESIS USING A REDUCED AMOUNT OF DETERGENT |
EP1701970A2 (en) * | 2003-12-31 | 2006-09-20 | F.Hoffmann-La Roche Ag | Methods for recovering cleaved peptide from a support |
WO2005063799A2 (en) * | 2003-12-31 | 2005-07-14 | F.Hoffmann-La Roche Ag | Peptide synthesis and deprotection with co-solvent |
EP1701972B1 (en) * | 2003-12-31 | 2008-10-08 | F. Hoffmann-La Roche Ag | Process and systems for recovery of peptides |
EP1708734A4 (en) * | 2004-01-07 | 2009-06-17 | Trimeris Inc | HIV gp41 HR2-DERIVED SYNTHETIC PEPTIDES, AND THEIR USE IN THERAPY TO INHIBIT TRANSMISSION OF HUMAN IMMUNODEFICIENCY VIRUS |
US20080027006A1 (en) * | 2004-02-12 | 2008-01-31 | The Regents Of The University Of Colorado | Compositions And Methods For Modification And Prevention Of Sars Coronavirus Infectivity |
US20080039532A1 (en) * | 2004-05-06 | 2008-02-14 | Dominique Bridon | Compounds For Specific Viral Target |
GB0422439D0 (en) * | 2004-10-08 | 2004-11-10 | European Molecular Biology Lab Embl | Inhibitors of infection |
US20100093767A1 (en) * | 2004-12-03 | 2010-04-15 | Takeda San Diego, Inc. | Mitotic Kinase Inhibitors |
CN101133077B (en) * | 2004-12-30 | 2012-09-05 | 弗·哈夫曼-拉罗切有限公司 | Synthesis using peptide intermediate fragments |
EP1856142B1 (en) * | 2004-12-30 | 2009-08-12 | F. Hoffmann-Roche AG | Synthesis of peptide t-1249 using peptide intermediate fragments |
AU2006207181A1 (en) * | 2005-01-24 | 2006-07-27 | Yeda Research & Development Co. Ltd. | HIV-1 gp41 fusion peptides for immunomodulation |
EP1937300A4 (en) * | 2005-08-17 | 2009-08-12 | Multicell Immunotherapeutics I | Methods and compositions to generate and control the effector profile of t cells by simultaneous loading and activation of selected subsets of antigen presenting cells |
US20070185025A1 (en) * | 2005-09-11 | 2007-08-09 | The Trustees Of Columbia University In The City Of New York | Filoviral immunosuppressive peptides and uses thereof |
WO2007097903A2 (en) | 2006-02-02 | 2007-08-30 | Trimeris, Inc. | Hiv fusion inhibitor peptides with improved biological properties |
US8216592B2 (en) * | 2006-04-19 | 2012-07-10 | The Reed Institute | Infection model for developing chemotherapeutic agents |
US8222204B2 (en) * | 2006-05-03 | 2012-07-17 | The Administrators of the Tulane Educational Fund and Autoimmune Technologies, LLC | Influenza inhibiting compositions and methods |
CN101088557A (en) | 2006-06-12 | 2007-12-19 | 天津市扶素生物技术有限公司 | Medicine composition for preventing and treating HIV infection and its application |
CN101502022B (en) | 2006-06-27 | 2013-09-11 | 日本电气株式会社 | Communication system, transmitter, receiver, and multiple access method |
JP5872755B2 (en) * | 2006-07-20 | 2016-03-01 | バイカル インコーポレイテッド | Compositions and methods for anti-HSV-2 vaccination |
BRPI0715794A2 (en) | 2006-08-17 | 2013-07-23 | Hoffmann La Roche | ccr5 antibody conjugate and antifusogenic peptide |
TW200817438A (en) * | 2006-08-17 | 2008-04-16 | Hoffmann La Roche | A conjugate of an antibody against CCR5 and an antifusogenic peptide |
AU2007331195A1 (en) | 2006-12-12 | 2008-06-19 | Biorexis Pharmaceutical Corporation | Transferrin fusion protein libraries |
US20090088378A1 (en) * | 2007-01-12 | 2009-04-02 | Omar Quraishi | Long lasting inhibitors of viral infection |
CL2008000707A1 (en) * | 2007-03-13 | 2008-09-22 | Hoffmann La Roche | CONJUGATE OF ANTIFUSOGENIC POLYPEPTIDES AND POLYPEPTIDES DERIVED FROM THE GLOBULAR HEAD OF THE COMPLEMENT FACTOR C1Q; PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS IT; ITS USE TO TREAT VIRIC INFECTIONS; AND PRODUCTION METHOD. |
EP2139526A4 (en) * | 2007-04-03 | 2010-07-14 | Trimeris Inc | Novel formulations for delivery of antiviral peptide therapeutics |
BRPI0811864A2 (en) * | 2007-05-16 | 2014-11-18 | Conjuchem Biotechnologies Inc | CYTISIC ACID DERIVATIVES FROM ANTIVIAL PEPTIDES |
CL2008002092A1 (en) | 2007-07-20 | 2009-05-29 | Hoffmann La Roche | Conjugate containing two or more antifusogenic peptides and an anti-cd-4 antibody; Method of production; pharmaceutical composition comprising it; antifusogenic polypeptides and use of the conjugate to treat viral infections. |
MX2010003179A (en) * | 2007-09-25 | 2010-04-30 | Trimeris Inc | Methods of synthesis for therapeuthic anti-hiv peptides. |
US20090131351A1 (en) * | 2007-11-16 | 2009-05-21 | Antisoma Research Limited | Methods, compositions, and kits for modulating tumor cell proliferation |
US7892562B2 (en) * | 2008-10-08 | 2011-02-22 | Karp Nelson M | Methods of inducing TH-1 immune responses to HIV-1 by administering UV/psoralen-treated desialated inactiviated HIV-1 virions deficient in CD55 and CD59 |
CA2761568C (en) | 2009-06-18 | 2020-10-13 | Dana-Farber Cancer Institute, Inc. | Structured viral peptide compositions and methods of use |
WO2011094363A2 (en) | 2010-01-26 | 2011-08-04 | The Regents Of The University Of Colorado | Influenza virus compositions and methods for universal vaccines |
US9782454B2 (en) | 2010-04-22 | 2017-10-10 | Longevity Biotech, Inc. | Highly active polypeptides and methods of making and using the same |
EP2616487B1 (en) | 2010-09-14 | 2015-03-25 | F.Hoffmann-La Roche Ag | Serpin-finger fusion polypeptide |
EP2447277A1 (en) | 2010-10-28 | 2012-05-02 | Laboratorios Del. Dr. Esteve, S.A. | Vaccine compositions based on modified gp41 immunogens |
CN103874710B (en) | 2011-04-01 | 2018-03-27 | 耶鲁大学 | The purposes that Premeabilisation of cells type anti-DNA antibody and its suppression DNA are repaired |
WO2013023362A1 (en) * | 2011-08-16 | 2013-02-21 | 深圳市卫武光明生物制品有限公司 | Cytomegalovirus human immunoglobulin for intravenous injection, and preparation method therefor |
WO2013049389A1 (en) | 2011-09-27 | 2013-04-04 | Yale University | Compositions and methods for transient expression of recombinant rna |
US8771698B2 (en) * | 2011-10-27 | 2014-07-08 | Institut National De La Recherche Scientifique | Modulation of UL24 interactions with protein targets and uses thereof for inhibition of herpesvirus infection |
EP2834264A1 (en) | 2012-04-04 | 2015-02-11 | Yeda Research and Development Co. Ltd. | Lipopeptide conjugates comprising sphingolipid and hiv gp41 derived peptides |
AU2013295242C1 (en) | 2012-07-27 | 2018-08-09 | Institut National De La Sante Et De La Recherche Medicale | CD147 as receptor for pilus-mediated adhesion of meningococci to vascular endothelia |
RU2670488C2 (en) * | 2012-09-13 | 2018-10-23 | Юниверсите Де Женев | Novel cell-penetrating peptides |
US9649375B2 (en) * | 2013-03-14 | 2017-05-16 | The Administrators Of The Tulane Educational Fund | Immunogenic peptide conjugate and method for inducing an anti-influenza therapeutic antibody response therewith |
CA2899089C (en) | 2013-03-15 | 2021-10-26 | Biogen Ma Inc. | Factor ix polypeptide formulations |
EP2968469A4 (en) | 2013-03-15 | 2016-08-31 | Longevity Biotech Inc | Peptides comprising non-natural amino acids and methods of making and using the same |
US9341391B2 (en) * | 2013-12-31 | 2016-05-17 | Bollente Companies, Inc. | Automatically controlled flow-through water heater system |
WO2015134607A1 (en) | 2014-03-04 | 2015-09-11 | Yale University | Cell penetrating anti-guanosine antibody based therapy for cancers with ras mutations |
US10238742B2 (en) | 2014-06-25 | 2019-03-26 | Yale University | Cell penetrating nucleolytic antibody based cancer therapy |
CA2954920A1 (en) * | 2014-07-14 | 2016-01-21 | The Regents Of The University Of California | A protein tagging system for in vivo single molecule imaging and control of gene transcription |
CN105989283B (en) | 2015-02-06 | 2019-08-09 | 阿里巴巴集团控股有限公司 | A kind of method and device identifying virus mutation |
FI3429618T3 (en) * | 2016-03-16 | 2024-03-15 | Amal Therapeutics Sa | Combination of an immune checkpoint modulator and a complex comprising a cell penetrating peptide, a cargo and a tlr peptide agonist for use in medicine |
US11590242B2 (en) | 2016-06-15 | 2023-02-28 | Yale University | Antibody-mediated autocatalytic, targeted delivery of nanocarriers to tumors |
AU2017331949A1 (en) | 2016-09-21 | 2019-01-31 | Amal Therapeutics Sa | Fusion comprising a cell penetrating peptide, a multi epitope and a TLR peptide agonist for treatment of cancer |
WO2018059216A1 (en) * | 2016-09-29 | 2018-04-05 | 广州君赫生物科技有限公司 | Compounds reducing saicar synthase activity, and applications |
AU2018253689B2 (en) | 2017-04-20 | 2020-07-23 | Geneheal Biotechnology Co., Ltd. | Applications of spermidine and its derivative |
EP3539562A1 (en) | 2018-03-12 | 2019-09-18 | Eberhard Karls Universität Tübingen Medizinische Fakultät | Immunotherapeutic peptides |
CN109207504B (en) * | 2018-09-26 | 2022-03-18 | 四川大学 | Preparation method of lactobacillus salivarius for effectively immunizing IB and ND |
JP7333538B2 (en) * | 2018-10-09 | 2023-08-25 | 東亞合成株式会社 | Antiviral peptide and its use |
CN109320594B (en) * | 2018-11-13 | 2021-09-28 | 四川大学 | Virus-like particle for avian infectious bronchitis and newcastle disease, preparation method and application |
CN112029735B (en) * | 2020-08-31 | 2022-04-12 | 中国农业科学院兰州兽医研究所 | Foot-and-mouth disease virus non-structural protein 3B dominant epitope deletion marker strain and preparation method and application thereof |
CN112410351A (en) * | 2020-11-12 | 2021-02-26 | 山东农业大学 | Duplex attenuated vaccine for resisting cucumber mosaic virus and potato virus X and application thereof |
CN112410312A (en) * | 2020-11-27 | 2021-02-26 | 江南大学 | Cyclohexanone monooxygenase and application thereof |
Family Cites Families (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
US4659669A (en) | 1981-03-02 | 1987-04-21 | Regents Of The Univ. Of California | Microbial expression of human influenza hemagglutinin proteins |
DE3380726D1 (en) | 1982-06-24 | 1989-11-23 | Japan Chem Res | Long-acting composition |
US4859765A (en) * | 1983-10-17 | 1989-08-22 | Syntex (U.S.A.) Inc. | Synthetic peptide sequences useful in biological and pharmaceutical applications and methods of manufacture |
US5843638A (en) | 1983-12-05 | 1998-12-01 | Institut Pasteur And Centre National De La Recherche Scientifique | Nucleic acids and pepties of human immunodeficiency virus type-1 (HIV-1). |
US4707358A (en) | 1984-01-30 | 1987-11-17 | The University Of Chicago | Vaccine against Epstein-Barr Virus |
US5116725A (en) | 1984-08-08 | 1992-05-26 | Scripps Clinic And Research Foundation | Assay for Epstein-Barr virus infection with solid phase bound synthetic polypeptides |
IL76082A (en) | 1984-08-22 | 1991-07-18 | Us Health | Molecular clones of the genome of htlv-iii and a process for the preparation thereof |
US6858712B1 (en) | 1984-08-22 | 2005-02-22 | The United States Of America As Represented By The Department Of Health And Human Services | Cloning and expression of HTLV-III DNA |
GB8501473D0 (en) | 1985-01-21 | 1985-02-20 | Pasteur Institut | Cloned dna sequences |
US5705612A (en) | 1984-10-18 | 1998-01-06 | Institut Pasteur And Centre National De La Recherche Scientifique | NEF peptide encoded by human immunodefiency virus type 1 (HIV-1) |
IE64006B1 (en) | 1984-10-18 | 1995-06-28 | Pasteur Institut | Antigens particulary envelope antigens of the virus of lymphadenopathies and of the acquired immune-deficiency syndrome and virus process for producing virus envelope antigens use of said antigens in the preparation of immunogenic compositions or for the diagnosis of the presence of antibodies against this virus |
CA1341482C (en) | 1984-10-31 | 2005-05-10 | Paul A. Luciw | Process for preparing fragments of aids-associated retroviruses |
DE3588134T2 (en) | 1984-12-24 | 1997-03-20 | Genentech Inc | Fusion of AIDS-related polypeptides |
US5853978A (en) | 1985-12-04 | 1998-12-29 | Genentech, Inc. | Molecularly cloned acquired immunodeficiency syndrome polypeptides and methods of use |
DE3650175T3 (en) | 1985-04-29 | 2007-09-06 | Bio-Rad Laboratories, Inc., Hercules | SYNTHETIC ANTIGENIC TO IDENTIFY AIDS. |
US4761470A (en) * | 1985-12-16 | 1988-08-02 | Merck & Co., Inc. | Immunogenic synthetic peptide capable of eliciting herpes simplex virus neutralizing antibody |
US5075211A (en) * | 1986-03-26 | 1991-12-24 | Genetic Systems Corporation | Synthetic antigen for the detection of AIDS-related disease |
DE3787002T2 (en) | 1986-12-30 | 1993-11-25 | Us Health | Synthetic peptides that generate cellular immunity to the AIDS virus and its proteins. |
ES2104556T3 (en) | 1987-01-16 | 1997-10-16 | Pasteur Institut | PEPTIDES THAT HAVE IMMUNOLOGICAL PROPERTIES OF HIV-2. |
US5141867A (en) * | 1987-02-02 | 1992-08-25 | E. I. Du Pont De Nemours And Company | Nucleotide sequence encoding a human immunodeficiency virus antigen |
NO881151L (en) | 1987-03-27 | 1988-09-28 | Syntello Ab | SYNTHETIC HIV-1 ANTIGEN. |
AU1711888A (en) * | 1987-04-24 | 1988-12-02 | Biogen, Inc. | Immunotherapeutic methods and compositions |
US5223254A (en) | 1987-09-29 | 1993-06-29 | Praxis Biologics, Inc. | Respiratory syncytial virus: vaccines |
EP0323157A3 (en) | 1987-12-24 | 1990-07-25 | The University Of Melbourne | Antiviral compounds and methods |
US5241047A (en) | 1988-12-08 | 1993-08-31 | Biochem Pharma Inc. | Synthetic peptides and mixtures thereof for detecting HIV antibodies |
AU608413B2 (en) | 1988-03-30 | 1991-03-28 | Abbott Laboratories | Mouse monoclonal antibody (5-21-3) to human immunodeficiency virus gp41 protein |
ATE105334T1 (en) * | 1988-04-22 | 1994-05-15 | Upjohn Co | CHIMAERIC GLYCOPROTEINS CONTAINING IMMUNOGENIC SECTIONS OF HUMAN PARAINFLUENZAVIRUS TYPE 3. |
EP0362909A3 (en) | 1988-08-26 | 1990-11-14 | Akzo N.V. | Synthetic polypeptides immunochemically reactive with hiv-antibodies |
EP0362910A3 (en) | 1988-08-27 | 1991-01-09 | Akzo N.V. | Synthetic peptides immunochemically reactive with hiv-antibodies |
EP0362927A3 (en) * | 1988-10-06 | 1990-11-14 | Akzo N.V. | Synthetic polypeptides immunochemically reactive with hiv antibodies |
US5268358A (en) * | 1988-12-08 | 1993-12-07 | Cor Therapeutics, Inc. | PDGF receptor blocking peptides |
US5057211A (en) | 1988-12-19 | 1991-10-15 | Baummer George P | Benefication apparatus and process for land and seabed mining |
DE68925909T2 (en) | 1988-12-20 | 1996-11-14 | Clarity Technologies Inc | SYNTHETIC HIV-LIKE PEPTIDES, THEIR COMPOSITIONS AND USES |
US6248574B1 (en) | 1989-12-13 | 2001-06-19 | Avigdor Shaffermann | Polypeptides selectively reactive with antibodies against human immunodeficiency virus and vaccines comprising the polypeptides |
FR2677346B1 (en) * | 1991-06-10 | 1993-08-27 | Atochem | PROCESS FOR PURIFYING AN AQUEOUS SOLUTION OF ALKALI METAL CHLORIDE BY REMOVING AMMONIUM AND IODINE. |
IL102092A (en) | 1991-06-11 | 1996-11-14 | Microgenesys Inc | Use of recombinant hiv envelope protein in medicament for treating hiv and therapeutic composition containing the agglomerated protein |
GB9120221D0 (en) * | 1991-09-23 | 1991-11-06 | Smithkline Beecham Biolog | Novel compounds |
GB9200117D0 (en) | 1992-01-06 | 1992-02-26 | Connaught Lab | Production of recombinant chimeric proteins for vaccine use |
FR2686899B1 (en) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | NOVEL BIOLOGICALLY ACTIVE POLYPEPTIDES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
US5444044A (en) | 1992-03-26 | 1995-08-22 | New York Blood Center | Synthetic polypeptides as inhibitors of HIV-1 |
WO1994002505A1 (en) * | 1992-07-20 | 1994-02-03 | Duke University | Compounds which inhibit hiv replication |
US6017536A (en) | 1993-06-07 | 2000-01-25 | Trimeris, Inc. | Simian immunodeficiency virus peptides with antifusogenic and antiviral activities |
US6479055B1 (en) | 1993-06-07 | 2002-11-12 | Trimeris, Inc. | Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission |
US5464933A (en) | 1993-06-07 | 1995-11-07 | Duke University | Synthetic peptide inhibitors of HIV transmission |
US20070202127A1 (en) | 1993-06-07 | 2007-08-30 | Duke University | Nucleic acids encoding DP-178 and other viral fusion inhibitor peptides useful for treating aids |
EP0741187A2 (en) | 1995-05-05 | 1996-11-06 | F. Hoffmann-La Roche Ag | Recombinant obese (Ob) proteins |
WO1996040191A1 (en) * | 1995-06-07 | 1996-12-19 | Trimeris, Inc. | The treatment of hiv and other viral infections using combinatory therapy |
US6156949A (en) * | 1998-12-28 | 2000-12-05 | Mobil Oil Corporation | Selective pseudocumene production by xylene methylation |
-
1995
- 1995-06-06 US US08/470,896 patent/US6479055B1/en not_active Expired - Lifetime
- 1995-06-07 US US08/484,741 patent/US6951717B1/en not_active Expired - Fee Related
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- 1995-06-07 US US08/487,266 patent/US6824783B1/en not_active Expired - Lifetime
- 1995-06-07 US US08/485,264 patent/US6228983B1/en not_active Expired - Fee Related
- 1995-06-07 US US08/471,913 patent/US6093794A/en not_active Expired - Fee Related
- 1995-06-07 US US08/484,223 patent/US7794725B1/en not_active Expired - Fee Related
- 1995-06-07 US US08/474,349 patent/US6333395B1/en not_active Expired - Fee Related
- 1995-06-07 US US08/485,551 patent/US6068973A/en not_active Expired - Fee Related
- 1995-06-07 US US08/486,099 patent/US6013263A/en not_active Expired - Fee Related
- 1995-12-20 EP EP05077520A patent/EP1714974A3/en not_active Withdrawn
- 1995-12-20 JP JP52000196A patent/JP2001523082A/en not_active Withdrawn
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- 1995-12-20 KR KR1019970704160A patent/KR100558087B1/en not_active IP Right Cessation
-
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- 1997-09-26 US US08/919,597 patent/US6054265A/en not_active Expired - Fee Related
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- 2002-10-08 US US10/267,748 patent/US7122190B2/en not_active Expired - Fee Related
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- 2010-06-02 US US12/791,983 patent/US20100291680A1/en not_active Abandoned
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014159813A1 (en) | 2013-03-13 | 2014-10-02 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
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