CA2217539C - Urinary bladder submucosa derived tissue graft - Google Patents

Urinary bladder submucosa derived tissue graft Download PDF

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Publication number
CA2217539C
CA2217539C CA2217539A CA2217539A CA2217539C CA 2217539 C CA2217539 C CA 2217539C CA 2217539 A CA2217539 A CA 2217539A CA 2217539 A CA2217539 A CA 2217539A CA 2217539 C CA2217539 C CA 2217539C
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Prior art keywords
graft
medical graft
tissue
urinary bladder
warm
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Expired - Lifetime
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CA2217539A
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French (fr)
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CA2217539A1 (en
Inventor
Stephen F. Badylak
Sherry L. Voytik
Andrew Brightman
Matt Waninger
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Purdue Research Foundation
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Purdue Research Foundation
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/22—Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
    • C12N2533/92—Amnion; Decellularised dermis or mucosa
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/915—Method or apparatus for preparing biological material

Abstract

A tissue graft composition comprising bladder submucosal tissue delaminated from abluminal muscle layers and at least the luminal portion of the tunica mucosa of a segment of vertebrate urinary bladder is described. The graft composition can be implanted to replace or support damaged or diseased tissues.

Description

URINARY BLADDER SUBMUCOSA DERIVED TISSUE GRAFT
Field of the Invention The present invention relates to a tissue graft composition and methods for its preparation and use. More particularly, the present invention is directed to non-immunogenic tissue graft compositions comprising urinary bladder submucosa and use of same to promote endogenous tissue growth.
Background and Summary of the Invention It is known that compositions comprising the tunica submucosa of the intestine of warm-blooded vertebrates can be used advantageously as tissue graft materials. See U.S. Patent Nos. 4,902,508 and 5,281,422.
The tissue graft compositions described in those patents are characterized by excellent mechanical properties, including high compliance, a high burst pressure point, and an effective porosity index which allows such compositions to be used beneficially for vascular graft and connective tissue graft constructs. When used in such applications the graft constructs appear not only to serve as a matrix for the regrowth of the tissues replaced by the graft constructs, but, indeed, to promote or induce such regrowth of endogenous tissue. Common events to this remodeling process include: widespread and very rapid neovascularization, proliferation of granulation mesenchymal cells, biodegradation/resorption of implanted intestinal submucosal tissue material, and lack of immune = 30 rejection.
It'is also known that intestinal submucosa can be fluidized by comminuting and/or protease digestion, without loss of its apparent'biotropic properties, for use in less invasive methods of administration (e.g., by injection or topical application) to host tissues in need of repair.
See U.S. Patent No. 5,275,826.
There has been much additional research effort directed to finding other natural and synthetic materials having the requisite properties for use as tissue grafts.
Surprisingly, it has been found that urinary bladder submucosa (UBS) prepared by delamination of bladder tissue of warm-blooded vertebrates exhibits mechanical and biotropic properties similar to that which has been reported for intestinal submucosal tissue. It can be substituted for intestinal submucosa tissue in most, if not all, of the applications previously reported for intestinal submucosa.
The tissue graft composition of the present invention comprises urinary bladder submucosa derived from urinary bladder tissue of a warm-blooded vertebrate. The wall of the urinary bladder is composed of the following layers: the tunica mucosa (including a transitional epithelium layer and the tunica propria), a submucosa layer, up to three layers of muscle and the adventitia (a loose connective tissue layer) - listed in thickness crossection from luminal to abluminal sides. Urinary bladder submucosa for use in accordance with the present invention is delaminated from the abluminal muscle layers and at least the luminal portion of the tunica mucosa of the urinary bladder tissue. The present graft composition can be implanted or injected into a vertebrate host to induce the repair or replacement of damaged or defective tissues.

-2a-Accordingly, the present invention provides a medical graft comprising urinary bladder submucosa delaminated from both an abluminal muscle layer and at least the luminal portion of the tunica mucosa of a segment of a urinary bladder of a warm-blooded vertebrate, wherein the graft is substantially acellular.

The invention further provides a non-immunogenic medical graft for inducing endogenous connective tissue growth when implanted in a warm-blooded vertebrate, said graft comprising urinary bladder submucosa delaminated from both an abluminal muscle layer and at least the luminal portion of the tunica mucosa of a segment of a urinary bladder of a warm-blooded vertebrate, wherein the graft is substantially acellular.

The invention further provides use of a medical graft to induce the formation of endogenous tissue at a site in need of endogenous tissue growth in a warm-blooded vertebrate, wherein said medical graft comprises a tissue material comprising submucosa from a urinary bladder of a second warm-blooded vertebrate, wherein the tissue material is sterilized, wherein said medical graft is substantially acellular, and wherein said medical graft is adapted to induce endogenous tissue growth at a site where the medical graft is to be administered.

The invention further provides a medical graft comprising a tissue material comprising submucosa, wherein said tissue material is isolated from a urinary bladder of a warm blooded vertebrate, wherein the tissue material is sterilized, and wherein the graft is substantially acellular.

-2b-Detailed Description of the Invention The tissue graft composition in accordance with the present invention comprises urinary bladder submucosa of a warm-blooded vertebrate delaminated from adjacent bladder tissue layers. The present tissue graft - J -composition thus comprises the bladder submucosa delaminated from abluminal muscle cell layers and at least the luminal portion of the mucosal layer of a segment of urinary bladder of a warm-blooded vertebrate. Typically the delamination technique described below provides a tissue composition consisting essentially of urinary bladder submucosa. These compositions are referred to herein generically as urinary bladder submucosa (UBS).
UBS graft material is typically prepared from bladder tissue harvested from animals raised for meat production, including, for example, pigs, cattle and sheep or other warm-blooded vertebrates. Thus, there is an inexpensive commercial source of urinary bladder tissue for use in preparation of the tissue compositions in accordance with the present invention.
The preparation of UBS from a segment of urinary bladder is similar to the procedure for pre paring intestinal submucosa detailed in U.S. Patent No. 4,902,509.
2.0 A segment of urinary bladder tissue is first subjected to abrasion using a .longitudinal wiping motion to remove both the outer 1-ayers (particularly the abluminal smooth muscle layers) and the luminal portions of the tunica mucosa layers - the epithelial layers). The resulting submucosa tissue has a thickness of about 80 micrometers, and consists primarily (greater than 98%) of acellular, eosinophilic staining (H&E stain) extracellular matrix material. Occasional blood vessels and spindle cells consistent with fibrocytes are scattered randomly throughout the tissue. Typically the UBS is rinsed with saline and optionally stored in a frozen hydrated state until used as described below.
Fluidized UBS can be prepared in a manner similar to the preparation of fluidized intestinal submucosa, as described in U.S. Patent No. 5,275,825.

The UBS is comminuted by tearing, cutting, grinding, shearing and the like. Grinding the UBS in a frozen or freeze-dried state is preferred although good results can be obtained as well by subjecting a suspension of submucosa pieces to treatment in a high speed (high shear) blender and dewatering, if necessary, by centrifuging and decanting excess water. Additionally, the comminuted fluidized tissue can be solubilized by enzymatic digestion of the bladder submucosa with a protease, such as trypsin or pepsin, or other appropriate enzymes for a period of time sufficient to solubilize said tissue and form a substantially homogeneous solution.
The present invention also contemplates the use of powder forms of UBS. In one embodiment a powder form of UBS is prepared by pulverizing urinary.bladder submucosa tissue under liquid nitrogen to produce particles ranging in size from 0.1 to 1 mm2. The particulate composition is then lyophilized overnight and sterilized to form a solid substantially anhydrous particulate composite.
Alternatively, a powder form of UBS can be formed from fluidized UBS by drying the suspensions or solutions of comminuted UBS.
The UBS tissue compositions of the present invention lend themselves to a wide variety of surgical applications relating to the repair or replacement of damaged tissues, including, for example the repair of Compositions comprising urinary bladder submucosa can be administered to a vertebrate host in an amount effective to induce endogenous tissue growth at a site in the host in need of same due to the presence of damaged or diseased tissue. The UBS compositions can be administered to the host in either solid or sheet form, by surgical implantation, or in fluidized form, by injection.
In one embodiment the present UBS compositions in sheet form can be used to form vascular grafts. The diameter of the graft should be about the same as the diameter of the recipient blood vessel. This is accomplished by manipulating the UBS to define a cylinder having diameter approximately the same as that of the recipient blood vessel and suturing or otherwise securing the tissue graft longitudinally to form said vascular graft. Thus, for example, a vascular graft can be prepared by selecting a sterile glass rod having an outer diameter equal to that of the recipient blood vessel, wrapping the UBS sheet around the glass rod and gathering the redundant tissue. The desired lumen diameter is achieved by suturing along the length of the graft (for example, using two continuous suture lines or a simple interrupted suture line) or by using other art-recognized tissue securing techniques. The vascular graft is surgically substituted for a damaged or diseased blood vessel using standard vascular surgery techniques.
Consistent with the use of UBS as a vascular graft material, UBS possesses mechanical properties highly desirable for such tissue graft materials, including low porosity index, high compliance, and a high burst pressure point. Those skilled in the art will appreciate that vascular graft material must be of low enough porosity to prevent intraoperative hemorrhage and yet of high enough porosity to allow extension of a newly-developed vasa vasorum through the graft material to nourish the luminal surface. Porosity of a graft material is typically measured in terms of ml of water passed per cm2min-' at a pressure of 120 mm Hg. UBS has a differential porosity to deionized water at 120 mm Hg pressure. The "porosity index" for UBS from the luminal toward abluminal direction is approximately 6.0; whereas the porosity index in the opposite direction is approximately 50. This property of differential porosity has also been noted for intestinal submucosal tissue but the values are an order of magnitude less than those values for UBS.
The UBS segments can also be used in accordance with-this invention as a tissue graft construct for use in the repair or replacement of connective tissues using the same procedures described for use of intestinal submucosa in U.S. Patent Nos. 5,281,422 and 5,352,463.
The UBS composition can be used in its delaminated natural sheet form or it can be cut longitudinally or laterally to form elongated tissue segments. Such segments or sheets have an intermediate portion, and opposite end portions and opposite lateral portions which can be formed for surgical attachment to existing physiological structures, using surgically acceptable techniques.
The grafts formed and used in accordance with this invention, upon implantation, undergo biological remodelling. They serve as a rapidly vascularized matrix for support and growth of new endogenous connective tissue.
When used as a tissue graft material UBS has been found to be trophic for host tissues with which it is attached or otherwise associated in its implanted environment. The graft material has been found to be remodelled (resorbed and replaced with autogenous differentiated tissue),to assume the characterizing features of the tissue(s) with which it is associated at the site of implantation. In tendon and ligament replacement studies the graft appears to develop a surface that is synovialized. Additionally, the boundaries between the graft and endogenous tissue are ti no longer discernible. Indeed, where a single graft "sees"
multiple microenvironments as implanted, it is differentially remodeled along its length. Thus, for example, when used in cruciate ligament replacement experiments, not only does the portion of the graft traversing the joint become vascularized and actually grow to look and function like the original ligament, but the portion of the graft in the femoral and tibial bone tunnels rapidly incorporates into and promotes development of the cortical and cancellous bone in those tunnels.
For tendon and ligament replacement applications, and other connective tissue repair applications UBS graft constructs are typically preconditioned by stretching longitudinally to a length longer than the length of the urinary bladder submucosa from which the graft construct was formed. One method of "pre-conditioning" involves application of a given load to the urinary bladder submucosa for three to five cycles. Each cycle consists of applying a load to the graft material for five seconds, followed by a ten second relaxation phase. Three to five cycles produces a stretch-conditioned graft material with reduced strain. The graft material does not return to its original size; it remains in a "stretched" dimension. For example, a UBS segment can be conditioned by suspending a weight from said segment, for a period of time sufficient to allow about 10 to about 20% or more elongation of the tissue segment. Optionally, the graft material can be = 30 preconditioned by stretching in the lateral dimension. The graft material exhibits similar viscoelastic properties in the longitudinal and lateral dimensions.
The graft segment is then formed in a variety of shapes and configurations, for example, to serve as a ligament or tendon replacement or a patch for a broken or severed tendon or ligament. Preferably, the segment is shaped and formed to have a layered or even a multilayered configuration with at least the opposite end portions and/or opposite lateral portions being formed to have multiple layers of the graft material to provide reinforcement for attachment to physiological structures, including bone, tendon, ligament, cartilage and muscle. In a ligament replacement application, opposite ends are attached using standard surgical technique to first and second bones, respectively, the bones typically being articulated as in the case of a knee joint.
The end portions of the UBS material can be formed, manipulated or shaped to be attached, for example, to a bone structure in a manner that will reduce the possibility of graft tearing at the point of attachment.
Preferably the material can be folded or partially exerted to provide multiple layers for gripping, for example, with spiked washers or staples.
Alternatively, the UBS material may be folded back on itself to join the end portions to provide a first connective portion to be attached, for example, to a first bone and a bend in the intermediate portion to provide a second connective portion to be attached to a second bone articulated with respect to the first bone. For example, one of the end portions may be adapted to be pulled through a tunnel in, for example, the femur and attached thereto, while the other of the end portions may be adapted to be pulled through a tunnel in the tibia and attached thereto to provide a substitute for the natural cruciate ligament, the segment being adapted to be placed under tension between the tunnels to provide a ligament function, i.e., a tensioning and positioning function provided by a normal ligament.
The present UBS composition may be sterilized using conventional sterilization techniques including tanning with glutaraldehyde, formaldehyde tanning at acidic pH, ethylene oxide treatment, propylene oxide treatment, gas plasma sterilization, gamma radiation, and peracetic acid sterilization. A sterilization technique which does not significantly weaken the mechanical strength and biotropic properties of the graft is preferably used. For instance, it is believed that strong gamma radiation may cause loss of strength in the graft material. Because one of the most attractive features of these intestinal submucosa grafts is their ability to induce host-remodelling responses, it is desirable not to use a sterilization approach which will detract from that property. Preferred sterilization techniques include exposing the graft to peracetic acid, low dose gamma irradiation and gas plasma sterilization; peracetic acid sterilization being the most preferred method. Typically, after the tissue graft composition has been sterilized, the composition is wrapped in a porous plastic wrap and sterilized again using electron beam or gamma irradiation sterilization techniques.

Claims (33)

CLAIMS:
1. A medical graft comprising urinary bladder submucosa delaminated from both an abluminal muscle layer and at least the luminal portion of the tunica mucosa of a segment of a urinary bladder of a warm blooded vertebrate, wherein the graft is substantially acellular.
2. The medical graft of claim 1 wherein the urinary bladder submucosa is fluidized.
3. The medical graft of claim 1 wherein the urinary bladder submucosa is digested with a protease for a period of time sufficient to solubilize the tissue and provide a substantially homogenous solution.
4. The medical graft of claim 1, wherein the urinary bladder submucosa is dried and in powder form.
5. The medical graft of claim 1 formed into a cylinder having a predetermined luminal diameter and sutured along the length of the cylinder.
6. The medical graft of claim 1 conditioned for use as a connective tissue substitute by stretching to produce a graft construct longer than the segment of urinary bladder tissue from which it is formed.
7. A non-immunogenic medical graft useful for inducing endogenous connective tissue growth when implanted in a warm-blooded vertebrate, said graft comprising urinary bladder submucosa delaminated from both an abluminal muscle layer and at least the luminal portion of the tunica mucosa of a segment of a urinary bladder of a warm-blooded vertebrate, wherein the graft is substantially acellular.
8. Use of a medical graft to induce the formation of endogenous tissue at a site in need of endogenous tissue growth in a warm-blooded vertebrate, wherein said medical graft comprises a tissue material comprising submucosa from a urinary bladder of a second warm-blooded vertebrate, wherein the tissue material is sterilized, wherein said medical graft is substantially acellular, and wherein said medical graft is adapted to induce endogenous tissue growth at a site where the medical graft is to be administered.
9. The use of claim 8, wherein the medical graft is fluidized and is adapted for administration by injection into the warm-blooded vertebrate.
10. The use of claim 8, wherein the medical graft is adapted for administration by surgical implantation of the medical graft into the warm-blooded vertebrate.
11. The use of claim 8 or claim 9 wherein the medical graft is digested with a protease for a period of time sufficient to solubilize the tissue material and provide a substantially homogenous solution.
12. The use of claim 8 wherein the submucosa from a urinary bladder is dried and in powder form.
13. The use of claim 8 wherein the graft is formed into a cylinder having a predetermined luminal diameter and is sutured along the length of the cylinder.
14. The use of claim 8 wherein the submucosa is delaminated from an abluminal muscle layer and at least the luminal portion of the tunica mucosa of a segment of the urinary bladder of a second warm-blooded vertebrate.
15. The use of claim 14 wherein the medical graft is conditioned for use as a connective tissue substitute such conditioning comprising longitudinal stretching of the medical graft to a length longer than the segment of the urinary bladder.
16. The use of claim 8 wherein the medical graft comprises multiple layers of the tissue material.
17. The use of claim 8 wherein the second warm-blooded vertebrate is a pig.
18. The use of claim 8 wherein said medical graft exhibits biotropic properties.
19. A medical graft comprising a tissue material comprising submucosa, wherein said tissue material is isolated from a urinary bladder of a warm blooded vertebrate, wherein the tissue material is sterilized, and wherein the graft is substantially acellular.
20. The medical graft of claim 19 wherein the warm-blooded vertebrate is a pig, a cow, or a sheep.
21. The medical graft of claim 19 or 20 wherein the tissue material is fluidized.
22. The medical graft of any one of claims 19 to 21 wherein the tissue material is in the form of pieces in suspension.
23. The medical graft of claim 19 or 20 wherein the tissue material is in powder form.
24. The medical graft of claim 19 or 20 wherein the tissue material is in the form of a tube.
25. The medical graft of claim 19 or 20 wherein the tissue material is in sheet form.
26. The medical graft of claim 19, 20, 24 or 25 wherein the medical graft comprises multiple layers.
27. The medical graft of any one of claims 19 to 22 wherein the graft is administerable by injection into the warm blooded vertebrate.
28. The medical graft of any one of claims 19, 20 and 23-26 wherein the graft is surgically implantable into the warm blooded vertebrate.
29. The medical graft of any one of claims 19, 20 and 23 wherein the tissue material is lyophilized.
30. The medical graft of any one of claims 19 to 29 wherein the warm-blooded vertebrate is a pig.
31. The medical graft of any one of claims 19 to 30 wherein said medical graft exhibits biotropic properties.
32. The medical graft of any one of claims 19 to 31 wherein the medical graft is sterilized using peracetic acid.
33. The medical graft of any one of claims 17 to 30 wherein the graft is effective to induce endogenous tissue when implanted in a warm blooded vertebrate.
CA2217539A 1995-04-07 1996-02-22 Urinary bladder submucosa derived tissue graft Expired - Lifetime CA2217539C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/418,763 US5554389A (en) 1995-04-07 1995-04-07 Urinary bladder submucosa derived tissue graft
US08/418,763 1995-04-07
PCT/US1996/002360 WO1996031225A1 (en) 1995-04-07 1996-02-22 Urinary bladder submucosa derived tissue graft

Publications (2)

Publication Number Publication Date
CA2217539A1 CA2217539A1 (en) 1996-10-10
CA2217539C true CA2217539C (en) 2012-01-03

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US (1) US5554389A (en)
EP (1) EP0819007B1 (en)
JP (2) JPH11503151A (en)
AR (1) AR001487A1 (en)
AU (1) AU691411B2 (en)
CA (1) CA2217539C (en)
DE (1) DE69621612T2 (en)
DK (1) DK0819007T3 (en)
ES (1) ES2177768T3 (en)
WO (1) WO1996031225A1 (en)

Families Citing this family (348)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6653291B1 (en) * 1992-11-13 2003-11-25 Purdue Research Foundation Composition and method for production of transformed cells
US6334872B1 (en) 1994-02-18 2002-01-01 Organogenesis Inc. Method for treating diseased or damaged organs
US6475232B1 (en) * 1996-12-10 2002-11-05 Purdue Research Foundation Stent with reduced thrombogenicity
US6485723B1 (en) * 1995-02-10 2002-11-26 Purdue Research Foundation Enhanced submucosal tissue graft constructs
US20020095218A1 (en) 1996-03-12 2002-07-18 Carr Robert M. Tissue repair fabric
US6171344B1 (en) * 1996-08-16 2001-01-09 Children's Medical Center Corporation Bladder submucosa seeded with cells for tissue reconstruction
AU780110B2 (en) * 1996-08-16 2005-03-03 Children's Medical Center Corporation Bladder submucosa seeded with cells for tissue reconstruction
CA2263144A1 (en) * 1996-08-16 1998-02-19 Children's Medical Center Corporation Bladder submucosa seeded with cells for tissue reconstruction
US20010048949A1 (en) * 1996-08-16 2001-12-06 Children's Medical Center Corporation Isolated bladder submucosa for tissue reconstruction
US8716227B2 (en) * 1996-08-23 2014-05-06 Cook Biotech Incorporated Graft prosthesis, materials and methods
EP0925077B1 (en) * 1996-08-23 2003-10-15 Cook Biotech, Inc. Method for obtaining a purified collagen-based matrix from submucosa tissue
US6666892B2 (en) * 1996-08-23 2003-12-23 Cook Biotech Incorporated Multi-formed collagenous biomaterial medical device
US5881733A (en) * 1996-09-13 1999-03-16 Depuy Orthopaedic Technology, Inc. Technique for osteocartilaginous transplantation in a mammalian joint
US5964805A (en) * 1997-02-12 1999-10-12 Stone; Kevin R. Method and paste for articular cartilage transplantation
EP1014887B1 (en) 1996-12-10 2006-04-19 Purdue Research Foundation Stent with reduced thrombogenicity
WO1998025635A1 (en) * 1996-12-10 1998-06-18 Purdue Research Foundation Submucosal tissue inhibition of neoplastic cell growth
AU743779B2 (en) 1996-12-10 2002-02-07 Cook Biotech, Inc. Tubular grafts from purified submucosa
WO1998025549A1 (en) 1996-12-10 1998-06-18 Purdue Research Foundation Artificial vascular valves
WO1998025964A1 (en) 1996-12-10 1998-06-18 Purdue Research Foundation Submucosa extracts
US6696270B2 (en) * 1996-12-10 2004-02-24 Purdue Research Foundation Gastric submucosal tissue as a novel diagnostic tool
US6110209A (en) * 1997-08-07 2000-08-29 Stone; Kevin R. Method and paste for articular cartilage transplantation
EP1011699B1 (en) * 1997-09-11 2001-12-05 Purdue Research Foundation Galactosidase modified submucosal tissue
US6371992B1 (en) * 1997-12-19 2002-04-16 The Regents Of The University Of California Acellular matrix grafts: preparation and use
US7070607B2 (en) * 1998-01-27 2006-07-04 The Regents Of The University Of California Bioabsorbable polymeric implants and a method of using the same to create occlusions
US6444229B2 (en) 1998-02-27 2002-09-03 Purdue Research Foundation Submucosa gel compositions
JP4341049B2 (en) * 1998-06-05 2009-10-07 オルガノジェネシス インク． Tubular graft prosthesis made by biotechnology
JP4341050B2 (en) * 1998-06-05 2009-10-07 オルガノジェネシス インク． Vascular graft prosthesis made by bioengineering
JP4606583B2 (en) * 1998-06-05 2011-01-05 オルガノジェネシス インク． Planar sheet transplant prosthesis using biotechnological techniques
CA2334228C (en) * 1998-06-05 2010-09-28 Organogenesis Inc. Bioengineered vascular graft support prostheses
US6458109B1 (en) 1998-08-07 2002-10-01 Hill-Rom Services, Inc. Wound treatment apparatus
US8882850B2 (en) * 1998-12-01 2014-11-11 Cook Biotech Incorporated Multi-formed collagenous biomaterial medical device
DK1051116T3 (en) 1998-12-01 2009-02-02 Univ Washington Embolization device
US6918396B1 (en) 1998-12-01 2005-07-19 Purdue Research Foundation Method for vocal cord reconstruction
WO2000032250A1 (en) * 1998-12-01 2000-06-08 Cook Biotech, Inc. A multi-formed collagenous biomaterial medical device
EP1207819B1 (en) * 1999-08-06 2009-03-04 Cook Biotech, Inc. Tubular graft construct
US6764462B2 (en) 2000-11-29 2004-07-20 Hill-Rom Services Inc. Wound treatment apparatus
US6824533B2 (en) 2000-11-29 2004-11-30 Hill-Rom Services, Inc. Wound treatment apparatus
US6579538B1 (en) 1999-12-22 2003-06-17 Acell, Inc. Tissue regenerative compositions for cardiac applications, method of making, and method of use thereof
US6576265B1 (en) 1999-12-22 2003-06-10 Acell, Inc. Tissue regenerative composition, method of making, and method of use thereof
WO2001045765A1 (en) 1999-12-22 2001-06-28 Acell, Inc. Tissue regenerative composition
US20040043006A1 (en) * 2002-08-27 2004-03-04 Badylak Stephen F. Tissue regenerative composition
WO2001054176A1 (en) 2000-01-18 2001-07-26 Xros, Inc., Nortel Networks Wafer bonding techniques to minimize built-in stress of silicon microstructures and micro-mirrors
DE60128069D1 (en) 2000-01-31 2007-06-06 Cook Biotech Inc STENT VALVE FLAP
US20050267560A1 (en) * 2000-02-03 2005-12-01 Cook Incorporated Implantable bioabsorbable valve support frame
ATE407647T1 (en) 2000-05-22 2008-09-15 Arthur C Coffey WOUND DRESSING WITH SIS LAYER AND VACUUM CHAMBER
US8366787B2 (en) 2000-08-04 2013-02-05 Depuy Products, Inc. Hybrid biologic-synthetic bioabsorbable scaffolds
US6638312B2 (en) * 2000-08-04 2003-10-28 Depuy Orthopaedics, Inc. Reinforced small intestinal submucosa (SIS)
EP1320390A2 (en) * 2000-09-18 2003-06-25 Organogenesis Inc. Bioengineered flat sheet graft prosthesis and its use
US6855135B2 (en) 2000-11-29 2005-02-15 Hill-Rom Services, Inc. Vacuum therapy and cleansing dressing for wounds
US6685681B2 (en) 2000-11-29 2004-02-03 Hill-Rom Services, Inc. Vacuum therapy and cleansing dressing for wounds
JP2004529711A (en) * 2001-05-07 2004-09-30 クロスカート インコーポレイテッド Submucosal xenograft
US20070038244A1 (en) * 2001-06-08 2007-02-15 Morris Edward J Method and apparatus for sealing access
US7993365B2 (en) * 2001-06-08 2011-08-09 Morris Innovative, Inc. Method and apparatus for sealing access
US20060004408A1 (en) * 2001-06-08 2006-01-05 Morris Edward J Method and apparatus for sealing access
US6702744B2 (en) 2001-06-20 2004-03-09 Advanced Cardiovascular Systems, Inc. Agents that stimulate therapeutic angiogenesis and techniques and devices that enable their delivery
AU2002320189B2 (en) * 2001-06-28 2007-04-26 Cook Biotech Incorporated Graft prosthesis devices containing renal capsule collagen
CA2452040C (en) * 2001-06-29 2011-03-22 Cook Biotech Incorporated Porous sponge matrix medical devices and methods
WO2003007789A2 (en) 2001-07-16 2003-01-30 Depuy Products, Inc. Porous extracellular matrix scaffold and method
US8025896B2 (en) 2001-07-16 2011-09-27 Depuy Products, Inc. Porous extracellular matrix scaffold and method
WO2003007784A2 (en) 2001-07-16 2003-01-30 Depuy Products, Inc. Meniscus regeneration device and method
WO2003007839A2 (en) 2001-07-16 2003-01-30 Depuy Products, Inc. Devices form naturally occurring biologically derived
JP4197157B2 (en) 2001-07-16 2008-12-17 デピュイ・プロダクツ・インコーポレイテッド Cartilage repair and reproduction apparatus and method
US7163563B2 (en) 2001-07-16 2007-01-16 Depuy Products, Inc. Unitary surgical device and method
US7201917B2 (en) * 2001-07-16 2007-04-10 Depuy Products, Inc. Porous delivery scaffold and method
US7361195B2 (en) 2001-07-16 2008-04-22 Depuy Products, Inc. Cartilage repair apparatus and method
US7819918B2 (en) 2001-07-16 2010-10-26 Depuy Products, Inc. Implantable tissue repair device
WO2003007790A2 (en) 2001-07-16 2003-01-30 Depuy Products, Inc. Hybrid biologic/synthetic porous extracellular matrix scaffolds
CA2462877A1 (en) 2001-10-11 2003-04-17 Hill-Rom Services, Inc. Waste container for negative pressure therapy
WO2003035125A2 (en) * 2001-10-26 2003-05-01 Cook Biotech Incorporated Medical graft device with meshed structure
US8608661B1 (en) 2001-11-30 2013-12-17 Advanced Cardiovascular Systems, Inc. Method for intravascular delivery of a treatment agent beyond a blood vessel wall
US7195624B2 (en) 2001-12-26 2007-03-27 Hill-Rom Services, Inc. Vented vacuum bandage with irrigation for wound healing and method
WO2003057307A1 (en) 2001-12-26 2003-07-17 Hill-Rom Services, Inc. Wound vacuum therapy dressing kit
US7534927B2 (en) 2001-12-26 2009-05-19 Hill-Rom Services, Inc. Vacuum bandage packing
US8529956B2 (en) 2002-03-18 2013-09-10 Carnell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
US20100254900A1 (en) * 2002-03-18 2010-10-07 Campbell Phil G Biocompatible polymers and Methods of use
AU2002359824A1 (en) 2002-04-10 2003-10-27 Hill-Rom Services, Inc. Access openings in vacuum bandage
CA2483908C (en) 2002-05-02 2012-02-21 Purdue Research Foundation Vascularization enhanced graft constructs
NZ536563A (en) 2002-05-02 2008-03-28 Purdue Research Foundation Vascularization enhanced graft constructs
EP1503789A4 (en) * 2002-05-02 2006-08-02 Purdue Research Foundation Vascularization enhanced graft constructs
CA2484614A1 (en) * 2002-05-02 2003-11-13 Cook Biotech Incorporated Cell-seeded extracellular matrix grafts
US7160326B2 (en) * 2002-06-27 2007-01-09 Depuy Products, Inc. Method and apparatus for implantation of soft tissue implant
US7361368B2 (en) 2002-06-28 2008-04-22 Advanced Cardiovascular Systems, Inc. Device and method for combining a treatment agent and a gel
US7550004B2 (en) * 2002-08-20 2009-06-23 Cook Biotech Incorporated Endoluminal device with extracellular matrix material and methods
EP1545644B2 (en) 2002-08-21 2018-02-28 KCI Medical Resources Wound packing for preventing wound closure
CA2496905A1 (en) * 2002-09-06 2004-03-18 Cook Biotech Incorporated Tissue graft prosthesis devices containing juvenile or small diameter submucosa
US20040175366A1 (en) * 2003-03-07 2004-09-09 Acell, Inc. Scaffold for cell growth and differentiation
US20040176855A1 (en) * 2003-03-07 2004-09-09 Acell, Inc. Decellularized liver for repair of tissue and treatment of organ deficiency
US7524332B2 (en) * 2003-03-17 2009-04-28 Cook Incorporated Vascular valve with removable support component
EP1610728B1 (en) * 2003-04-01 2011-05-25 Cook Incorporated Percutaneously deployed vascular valves
US8821473B2 (en) 2003-04-15 2014-09-02 Abbott Cardiovascular Systems Inc. Methods and compositions to treat myocardial conditions
US8383158B2 (en) * 2003-04-15 2013-02-26 Abbott Cardiovascular Systems Inc. Methods and compositions to treat myocardial conditions
US8038991B1 (en) 2003-04-15 2011-10-18 Abbott Cardiovascular Systems Inc. High-viscosity hyaluronic acid compositions to treat myocardial conditions
US7067123B2 (en) 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US7105001B2 (en) * 2003-05-21 2006-09-12 Mandelbaum Jon A Surgical method and composition utilizing submucosal tissue to prevent incisional hernias
AU2004253508A1 (en) 2003-06-25 2005-01-13 Acell, Inc. Conditioned matrix compositions for tissue restoration
US8021692B2 (en) 2003-08-25 2011-09-20 Cook Biotech Incorporated Graft materials containing bioactive substances, and methods for their manufacture
AU2004270239C1 (en) * 2003-09-04 2011-07-07 Cook Biotech Incorporated Extracellular matrix composite materials, and manufacture and use thereof
US7645229B2 (en) * 2003-09-26 2010-01-12 Armstrong David N Instrument and method for endoscopic visualization and treatment of anorectal fistula
ES2396689T3 (en) 2003-12-11 2013-02-25 Isto Technologies Inc. Particle Cartilage System
ATE468815T1 (en) * 2004-01-21 2010-06-15 Cook Inc IMPLANTABLE TRANSPLANT FOR CLOSING A FISTULA
WO2005077433A1 (en) * 2004-02-09 2005-08-25 Cook Biotech Incorporated Stent graft devices having collagen coating
GB2451776B (en) 2004-02-17 2009-04-08 Cook Biotech Inc Medical devices and methods useful for applying bolster material
US7840263B2 (en) 2004-02-27 2010-11-23 Cardiac Pacemakers, Inc. Method and apparatus for device controlled gene expression
US7449027B2 (en) * 2004-03-29 2008-11-11 Cook Incorporated Modifying fluid flow in a body vessel lumen to promote intraluminal flow-sensitive processes
GB2429162B (en) 2004-03-29 2009-03-25 Cook Biotech Inc Methods for producing medical graft products with differing regions
JP2007532153A (en) * 2004-03-31 2007-11-15 クック インコーポレイテッド Graft material based on ECM
DE602005020754D1 (en) * 2004-03-31 2010-06-02 Cook Inc TRANSPLANT MATERIAL AND VASCOPY THERAPY WITH EXTRACELLULAR COLLAGEN MATRIX AND ITS MANUFACTURING PROCESS
US7569233B2 (en) 2004-05-04 2009-08-04 Depuy Products, Inc. Hybrid biologic-synthetic bioabsorbable scaffolds
US7764995B2 (en) 2004-06-07 2010-07-27 Cardiac Pacemakers, Inc. Method and apparatus to modulate cellular regeneration post myocardial infarct
US20050288796A1 (en) * 2004-06-23 2005-12-29 Hani Awad Native soft tissue matrix for therapeutic applications
CA2570142A1 (en) * 2004-07-07 2006-02-09 Cook Incorporated Graft, stent graft and method for manufacture
CA2575240A1 (en) 2004-07-30 2006-02-09 Cook Biotech Incorporated Graft with increased resistance to enzymatic degradation
US8257715B1 (en) 2004-08-26 2012-09-04 University Of Notre Dame Tissue vaccines and uses thereof
US7837740B2 (en) * 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
AU2005295737A1 (en) * 2004-10-15 2006-04-27 Cook Biotech Incorporated Fibronectin-modified ECM tissue graft constructs and methods for preparation and use thereof
WO2006050459A2 (en) * 2004-10-28 2006-05-11 Cook Incorporated Methods and systems for modifying vascular valves
US7458987B2 (en) * 2004-10-29 2008-12-02 Cook Incorporated Vascular valves having implanted and target configurations and methods of preparing the same
US7513866B2 (en) 2004-10-29 2009-04-07 Depuy Products, Inc. Intestine processing device and associated method
US7905826B2 (en) * 2004-11-03 2011-03-15 Cook Incorporated Methods for modifying vascular vessel walls
US8329202B2 (en) * 2004-11-12 2012-12-11 Depuy Products, Inc. System and method for attaching soft tissue to an implant
US7744621B2 (en) * 2004-12-06 2010-06-29 Cook Incorporated Inflatable occlusion devices, methods, and systems
WO2006062976A2 (en) 2004-12-07 2006-06-15 Cook Incorporated Methods for modifying vascular vessel walls
US8874204B2 (en) * 2004-12-20 2014-10-28 Cardiac Pacemakers, Inc. Implantable medical devices comprising isolated extracellular matrix
US8060219B2 (en) 2004-12-20 2011-11-15 Cardiac Pacemakers, Inc. Epicardial patch including isolated extracellular matrix with pacing electrodes
US7981065B2 (en) 2004-12-20 2011-07-19 Cardiac Pacemakers, Inc. Lead electrode incorporating extracellular matrix
US7354627B2 (en) 2004-12-22 2008-04-08 Depuy Products, Inc. Method for organizing the assembly of collagen fibers and compositions formed therefrom
EP1833384B1 (en) * 2004-12-30 2017-08-16 Cook Medical Technologies LLC Inverting occlusion devices and systems
US8128680B2 (en) 2005-01-10 2012-03-06 Taheri Laduca Llc Apparatus and method for deploying an implantable device within the body
US8287583B2 (en) 2005-01-10 2012-10-16 Taheri Laduca Llc Apparatus and method for deploying an implantable device within the body
US20060206139A1 (en) * 2005-01-19 2006-09-14 Tekulve Kurt J Vascular occlusion device
US8303647B2 (en) * 2005-03-03 2012-11-06 Cook Medical Technologies Llc Medical valve leaflet structures with peripheral region receptive to tissue ingrowth
US9138445B2 (en) * 2005-03-09 2015-09-22 Cook Biotech Incorporated Medical graft materials with adherent extracellular matrix fibrous mass
US8454678B2 (en) * 2005-03-19 2013-06-04 Cook Biotech Incorporated Prosthetic implants including ECM composite material
US9539410B2 (en) 2005-04-19 2017-01-10 Abbott Cardiovascular Systems Inc. Methods and compositions for treating post-cardial infarction damage
US8187621B2 (en) 2005-04-19 2012-05-29 Advanced Cardiovascular Systems, Inc. Methods and compositions for treating post-myocardial infarction damage
US8303972B2 (en) 2005-04-19 2012-11-06 Advanced Cardiovascular Systems, Inc. Hydrogel bioscaffoldings and biomedical device coatings
US20080125745A1 (en) 2005-04-19 2008-05-29 Shubhayu Basu Methods and compositions for treating post-cardial infarction damage
US8828433B2 (en) * 2005-04-19 2014-09-09 Advanced Cardiovascular Systems, Inc. Hydrogel bioscaffoldings and biomedical device coatings
JP4995811B2 (en) 2005-04-29 2012-08-08 クック・バイオテック・インコーポレーテッド Acupuncture positive displacement implants and related methods and systems
EP1980275B1 (en) 2005-04-29 2016-01-27 Cook Biotech, Inc. Fistula graft with deformable sheet-form material
AU2006244393B2 (en) * 2005-05-05 2012-06-21 Cook Biotech Incorporated Implantable materials and methods for inhibiting tissue adhesion formation
US8048446B2 (en) * 2005-05-10 2011-11-01 Drexel University Electrospun blends of natural and synthetic polymer fibers as tissue engineering scaffolds
US8518436B2 (en) * 2005-05-16 2013-08-27 Purdue Research Foundation Engineered extracellular matrices
WO2006125055A2 (en) * 2005-05-17 2006-11-23 Cook Incorporated Prosthetic valve devices and methods of making and using such devices
WO2007002260A2 (en) * 2005-06-21 2007-01-04 Cook Incorporated Implantable graft to close a fistula
US20060292227A1 (en) * 2005-06-23 2006-12-28 Mcpherson Timothy B Extracellular matrix material particles and methods of preparation
US9271817B2 (en) * 2005-07-05 2016-03-01 Cook Biotech Incorporated Tissue augmentation devices and methods
US7850985B2 (en) 2005-07-05 2010-12-14 Cook Biotech Incorporated Tissue augmentation devices and methods
US7815926B2 (en) * 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
US20070014868A1 (en) * 2005-07-15 2007-01-18 Cormatrix Cardiovascular, Inc. Patch for reconstruction, replacement or repair of the pericardial sac
US20070014869A1 (en) * 2005-07-15 2007-01-18 Cormatrix Cardiovascular, Inc. Compositions for reconstruction, replacement or repair of intracardiac tissue
US8568761B2 (en) * 2005-07-15 2013-10-29 Cormatrix Cardiovascular, Inc. Compositions for regenerating defective or absent myocardium
WO2007011644A2 (en) * 2005-07-15 2007-01-25 Cormatrix Cardiovascular, Inc. Compositions for regenerating defective or absent tissue
EP2093256A3 (en) 2005-07-28 2009-10-14 Carnegie Mellon University Biocompatible polymers and methods of use
US7595062B2 (en) 2005-07-28 2009-09-29 Depuy Products, Inc. Joint resurfacing orthopaedic implant and associated method
US20070038295A1 (en) * 2005-08-12 2007-02-15 Cook Incorporated Artificial valve prosthesis having a ring frame
US8771340B2 (en) * 2005-08-25 2014-07-08 Cook Medical Technologies Llc Methods and devices for the endoluminal deployment and securement of prostheses
JP5292533B2 (en) 2005-08-26 2013-09-18 ジンマー・インコーポレイテッド Implant and joint disease treatment, replacement and treatment methods
US8470022B2 (en) * 2005-08-31 2013-06-25 Cook Biotech Incorporated Implantable valve
EP1928512B1 (en) * 2005-09-01 2012-11-14 Cook Medical Technologies LLC Attachment of material to an implantable frame by cross-linking
CA2623106C (en) 2005-09-19 2013-12-24 Histogenics Corporation Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof
JP5063603B2 (en) * 2005-09-30 2012-10-31 クック メディカル テクノロジーズ エルエルシー Coated vascular occlusion device
US7503928B2 (en) 2005-10-21 2009-03-17 Cook Biotech Incorporated Artificial valve with center leaflet attachment
US7563277B2 (en) 2005-10-24 2009-07-21 Cook Incorporated Removable covering for implantable frame projections
US8802113B2 (en) * 2005-10-27 2014-08-12 University Of Notre Dame Extracellular matrix cancer vaccine adjuvant
US8778362B2 (en) 2005-10-27 2014-07-15 University Of Notre Dame Anti-tumor/cancer heterologous acellular collagenous preparations and uses thereof
US8778360B2 (en) * 2005-10-27 2014-07-15 University Of Notre Dame Extracellular matrix cancer vaccine adjuvant
US9308252B2 (en) * 2005-10-27 2016-04-12 Cook Biotech, Inc. Extracellular matrix materials as vaccine adjuvants for diseases associated with infectious pathogens or toxins
CA2630452C (en) * 2005-12-02 2011-02-22 Cook Incorporated Devices, systems, and methods for occluding a defect
US7815923B2 (en) 2005-12-29 2010-10-19 Cook Biotech Incorporated Implantable graft material
WO2007079081A1 (en) * 2005-12-29 2007-07-12 Med Institute, Inc. Endoluminal device including a mechanism for proximal or distal fixation, and sealing and methods of use thereof
WO2007081530A2 (en) * 2006-01-03 2007-07-19 Med Institute, Inc. Endoluminal medical device for local delivery of cathepsin inhibitors
US20070166396A1 (en) 2006-01-06 2007-07-19 University Of Pittsburgh Extracellular matrix based gastroesophageal junction reinforcement device
AU2007210970B2 (en) * 2006-01-31 2013-09-05 Cook Biotech Incorporated Fistula grafts and related methods and systems for treating fistulae
US7648527B2 (en) * 2006-03-01 2010-01-19 Cook Incorporated Methods of reducing retrograde flow
US20070269476A1 (en) * 2006-05-16 2007-11-22 Voytik-Harbin Sherry L Engineered extracellular matrices control stem cell behavior
DE112007001197T5 (en) 2006-05-16 2009-04-16 Purdue Research Foundation, West Lafayette Three-dimensional purified collagen matrices
EP2478872B1 (en) 2006-05-30 2018-07-04 Cook Medical Technologies LLC Artificial valve prosthesis
WO2007147127A2 (en) 2006-06-15 2007-12-21 Cook Incorporated Methods, systems, and devices for the delivery of endoluminal prostheses
CA2662901A1 (en) 2006-06-21 2007-12-27 Cook Incorporated Fistula grafts and related methods and systems useful for treating gastrointestinal fistulae
US8974542B2 (en) 2006-06-27 2015-03-10 University of Pittsburgh—of the Commonwealth System of Higher Education Biodegradable elastomeric patch for treating cardiac or cardiovascular conditions
US8535719B2 (en) * 2006-07-07 2013-09-17 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Biohybrid elastomeric scaffolds and methods of use thereof
US7732190B2 (en) 2006-07-31 2010-06-08 Advanced Cardiovascular Systems, Inc. Modified two-component gelation systems, methods of use and methods of manufacture
US20080109070A1 (en) * 2006-08-10 2008-05-08 Wagner William R Biodegradable elastomeric scaffolds containing microintegrated cells
US9242005B1 (en) 2006-08-21 2016-01-26 Abbott Cardiovascular Systems Inc. Pro-healing agent formulation compositions, methods and treatments
AU2007286657B2 (en) 2006-08-24 2012-11-15 Cook Medical Technologies Llc Devices and methods for occluding a fistula
US20080063627A1 (en) * 2006-09-12 2008-03-13 Surmodics, Inc. Tissue graft materials containing biocompatible agent and methods of making and using same
AU2007297611B2 (en) 2006-09-21 2013-02-07 Purdue Research Foundation Collagen preparation and method of isolation
US8529959B2 (en) 2006-10-17 2013-09-10 Carmell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
EP2079490B1 (en) 2006-10-23 2012-08-29 Cook Biotech Incorporated Processed ecm materials with enhanced component profiles
US9005672B2 (en) 2006-11-17 2015-04-14 Abbott Cardiovascular Systems Inc. Methods of modifying myocardial infarction expansion
US8741326B2 (en) 2006-11-17 2014-06-03 Abbott Cardiovascular Systems Inc. Modified two-component gelation systems, methods of use and methods of manufacture
US8192760B2 (en) 2006-12-04 2012-06-05 Abbott Cardiovascular Systems Inc. Methods and compositions for treating tissue using silk proteins
US7871440B2 (en) 2006-12-11 2011-01-18 Depuy Products, Inc. Unitary surgical device and method
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
CA2674859A1 (en) * 2007-01-10 2008-07-17 Cook Biotech Incorporated Implantable devices useful for reinforcing a surgically created stoma
US8343536B2 (en) 2007-01-25 2013-01-01 Cook Biotech Incorporated Biofilm-inhibiting medical products
US9526642B2 (en) 2007-02-09 2016-12-27 Taheri Laduca Llc Vascular implants and methods of fabricating the same
JP5662683B2 (en) 2007-02-09 2015-02-04 タヘリ ラドュカ エルエルシー Apparatus and method for deploying an implantable device in a body
US20080260794A1 (en) * 2007-02-12 2008-10-23 Lauritzen Nels J Collagen products and methods for producing collagen products
US9056151B2 (en) * 2007-02-12 2015-06-16 Warsaw Orthopedic, Inc. Methods for collagen processing and products using processed collagen
WO2008101083A2 (en) 2007-02-15 2008-08-21 Cook Incorporated Artificial valve prostheses with a free leaflet portion
US8361503B2 (en) * 2007-03-02 2013-01-29 University of Pittsburgh—of the Commonwealth System of Higher Education Extracellular matrix-derived gels and related methods
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
GB2461461B (en) * 2007-04-06 2012-07-25 Cook Biotech Inc Fistula plugs having increased column strength and fistula plug delivery apparatuses and methods
WO2008128075A1 (en) 2007-04-12 2008-10-23 Isto Technologies, Inc. Compositions and methods for tissue repair
US8591930B2 (en) * 2007-04-27 2013-11-26 Cook Biotech Incorporated Growth factor modified extracellular matrix material preparation and methods for preparation and use thereof
US20080279833A1 (en) 2007-05-10 2008-11-13 Matheny Robert G Laminate sheet articles for tissue regeneration
US9283302B2 (en) 2011-12-16 2016-03-15 Cormatrix Cardiovascular, Inc. Extracellular matrix encasement structures and methods
ES2612538T3 (en) 2007-05-29 2017-05-17 Christopher B. Reid Methods for production and uses of multipotent cell populations, pluripotent cell populations, differentiated cell populations, and HIV resistant cell populations
US20090142400A1 (en) * 2007-05-31 2009-06-04 Hiles Michael C Analgesic coated medical product
US8535349B2 (en) * 2007-07-02 2013-09-17 Cook Biotech Incorporated Fistula grafts having a deflectable graft body portion
US20090024106A1 (en) * 2007-07-17 2009-01-22 Morris Edward J Method and apparatus for maintaining access
US9113851B2 (en) 2007-08-23 2015-08-25 Cook Biotech Incorporated Fistula plugs and apparatuses and methods for fistula plug delivery
US20090069843A1 (en) * 2007-09-10 2009-03-12 Agnew Charles W Fistula plugs including a hydration resistant component
US8029560B2 (en) * 2007-09-12 2011-10-04 Cook Medical Technologies Llc Enhanced remodelable materials for occluding bodily vessels
US20090082816A1 (en) 2007-09-20 2009-03-26 Graham Matthew R Remodelable orthopaedic spacer and method of using the same
US20090136553A1 (en) * 2007-09-25 2009-05-28 Gerlach Jorg C Triggerably dissolvable hollow fibers for controlled delivery
US20100135964A1 (en) * 2007-09-27 2010-06-03 Alvarado Carlos A Tissue grafting method
US9023342B2 (en) 2007-09-27 2015-05-05 Carlos A. Alvarado Tissue grafting method
US10500309B2 (en) 2007-10-05 2019-12-10 Cook Biotech Incorporated Absorbable adhesives and their formulation for use in medical applications
US20090112238A1 (en) * 2007-10-26 2009-04-30 Vance Products Inc., D/B/A Cook Urological Inc. Fistula brush device
JP5214223B2 (en) * 2007-11-15 2013-06-19 船井電機株式会社 projector
US7846199B2 (en) 2007-11-19 2010-12-07 Cook Incorporated Remodelable prosthetic valve
US8057532B2 (en) * 2007-11-28 2011-11-15 Cook Medical Technologies Llc Implantable frame and valve design
CA2708615C (en) * 2007-12-10 2019-12-31 Purdue Research Foundation Collagen-based matrices with stem cells
US8257434B2 (en) 2007-12-18 2012-09-04 Cormatrix Cardiovascular, Inc. Prosthetic tissue valve
US8679176B2 (en) 2007-12-18 2014-03-25 Cormatrix Cardiovascular, Inc Prosthetic tissue valve
US20090157177A1 (en) * 2007-12-18 2009-06-18 Matheny Robert G Sewing Ring for a Prosthetic Tissue Valve
US20090157170A1 (en) * 2007-12-18 2009-06-18 Matheny Robert G Trileaflet Semi-Lunar Prosthetic Tissue Valve
US8211165B1 (en) 2008-01-08 2012-07-03 Cook Medical Technologies Llc Implantable device for placement in a vessel having a variable size
US9283266B2 (en) * 2008-02-28 2016-03-15 University Of Notre Dame Metastasis inhibition preparations and methods
EP2259809B1 (en) * 2008-02-29 2016-05-25 Cook Biotech Incorporated Coated embolization device
WO2009111069A1 (en) 2008-03-05 2009-09-11 Musculoskeletal Transplant Foundation Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
US20100008965A1 (en) * 2008-04-01 2010-01-14 Pavalko Fredrick M Biocompatible medical products having enhanced anti-thrombogenic properties
US8128686B2 (en) * 2008-04-18 2012-03-06 Cook Medical Technologies Llc Branched vessel prosthesis
GB2471632B (en) * 2008-05-02 2012-04-18 Cook Biotech Inc Self deploying SIS in needle
US20110184439A1 (en) * 2008-05-09 2011-07-28 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Biological Matrix for Cardiac Repair
WO2009146369A1 (en) 2008-05-29 2009-12-03 Cook Biotech Incorporated Devices and methods for treating rectovaginal and other fistulae
CA2728240C (en) * 2008-06-10 2016-11-15 Cook Biotech Incorporated Quilted implantable graft
US9295757B2 (en) * 2008-06-10 2016-03-29 Cook Biotech Incorporated Quilted implantable graft
US8118832B1 (en) 2008-06-16 2012-02-21 Morris Innovative, Inc. Method and apparatus for sealing access
JP2011526811A (en) * 2008-07-01 2011-10-20 クック・バイオテック・インコーポレイテッド Isolated extracellular matrix material containing subserosa fascia
WO2010014021A1 (en) 2008-07-30 2010-02-04 Mesynthes Limited Tissue scaffolds derived from forestomach extracellular matrix
US20110190680A1 (en) 2008-09-29 2011-08-04 Yoram Vodovotz Self-Regulating Device for Modulating Inflammation
WO2010065843A2 (en) 2008-12-05 2010-06-10 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Biologic scaffold for prevention of pulmonary fibrosis
WO2010078478A1 (en) 2008-12-31 2010-07-08 Cook Biotech Incorporated Tissue adjuvants and medical products including the same
US20100274362A1 (en) * 2009-01-15 2010-10-28 Avner Yayon Cartilage particle tissue mixtures optionally combined with a cancellous construct
WO2010088678A2 (en) 2009-02-02 2010-08-05 Cook Biotech Incorporated Medical bead products
WO2010096458A1 (en) 2009-02-18 2010-08-26 Cormatrix Cardiovascular, Inc. Compositions and methods for preventing cardiac arrhythmia
US9277999B2 (en) * 2009-02-27 2016-03-08 University of Pittsburgh—of the Commonwealth System of Higher Education Joint bioscaffolds
WO2010129162A1 (en) 2009-05-06 2010-11-11 Hansa Medical Products, Inc. Self-adjusting medical device
US8298586B2 (en) * 2009-07-22 2012-10-30 Acell Inc Variable density tissue graft composition
US8652500B2 (en) 2009-07-22 2014-02-18 Acell, Inc. Particulate tissue graft with components of differing density and methods of making and using the same
WO2011031827A2 (en) 2009-09-09 2011-03-17 Cook Biotech Incorporated Manufacture of extracellular matrix products using supercritical or near supercritical fluids
US8663086B2 (en) * 2009-09-28 2014-03-04 Cook Biotech Incorporated Medical reinforcement graft
US8716438B2 (en) 2009-10-09 2014-05-06 University of Pittsburgh—of the Commonwealth System of Higher Education Matricryptic ECM peptides for tissue reconstruction
US8846059B2 (en) 2009-12-08 2014-09-30 University Of Notre Dame Extracellular matrix adjuvant and methods for prevention and/or inhibition of ovarian tumors and ovarian cancer
US20110150934A1 (en) * 2009-12-18 2011-06-23 University Of Notre Dame Ovarian Tumor Tissue Cell Preparations/Vaccines for the Treatment/Inhibition of Ovarian Tumors and Ovarian Cancer
WO2011087743A2 (en) 2009-12-22 2011-07-21 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Decellularized adipose cell growth scaffold
US8329219B2 (en) 2009-12-22 2012-12-11 Cook Biotech Incorporated Methods for producing ECM-based biomaterials
US8460691B2 (en) 2010-04-23 2013-06-11 Warsaw Orthopedic, Inc. Fenestrated wound repair scaffold
US8790699B2 (en) 2010-04-23 2014-07-29 Warsaw Orthpedic, Inc. Foam-formed collagen strand
US9901659B2 (en) 2010-05-27 2018-02-27 University of Pittsburgh—of the Commonwealth System of Higher Education Wet-electrospun biodegradable scaffold and uses therefor
US20130197893A1 (en) 2010-06-07 2013-08-01 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods for modeling hepatic inflammation
EP2598181B1 (en) 2010-07-31 2021-04-21 Cook Medical Technologies LLC Collagenous tissue pocket for an implantable medical device, and manufacturing method therefor
US9101455B2 (en) 2010-08-13 2015-08-11 Cook Medical Technologies Llc Preloaded wire for endoluminal device
CA2747610C (en) 2010-08-13 2014-09-16 Cook Medical Technologies Llc Precannulated fenestration
WO2012024390A2 (en) 2010-08-17 2012-02-23 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Biohybrid composite scaffold
EP3610861A1 (en) 2010-08-24 2020-02-19 The Regents of the University of California Compositions and methods for cardiac therapy
EP2621549B1 (en) 2010-09-28 2015-10-21 Cook Biotech Incorporated Device for treating fistulae and other bodily openings and passageways
DE112011102907T5 (en) 2010-10-01 2013-06-20 Cook Biotech Incorporated Kits, components and methods for tissue reconstruction
SG194880A1 (en) 2011-05-27 2013-12-30 Cormatrix Cardiovascular Inc Sterilized, acellular extracellular matrix compositions and methods ofmaking thereof
BR112013030482A2 (en) 2011-05-27 2016-09-27 Cormatrix Cardiovascular Inc method of regeneration of an atrioventricular valve and duct of extracellular matrix material
WO2012170538A2 (en) 2011-06-06 2012-12-13 Cook Medical Technologies Llc Vascular occlusion devices and methods
US8915941B2 (en) 2011-06-14 2014-12-23 Cook Medical Technologies Llc Fistula closure devices and methods
US10022263B2 (en) 2011-07-14 2018-07-17 Cook Medical Technologies Llc Sling-based treatment of obstructive sleep apnea
JP2014529470A (en) 2011-09-01 2014-11-13 クック・メディカル・テクノロジーズ・リミテッド・ライアビリティ・カンパニーＣｏｏｋ Ｍｅｄｉｃａｌ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｌｌｃ Aneurysm occlusion clip
WO2013036708A2 (en) 2011-09-07 2013-03-14 The Regents Of The University Of California Compositions and methods for tissue repair with extracellular matrices
US8728148B2 (en) 2011-11-09 2014-05-20 Cook Medical Technologies Llc Diameter reducing tie arrangement for endoluminal prosthesis
US20130138219A1 (en) 2011-11-28 2013-05-30 Cook Medical Technologies Llc Biodegradable stents having one or more coverings
JP5902827B2 (en) 2011-12-09 2016-04-13 アセル，インコーポレイテッド Hemostatic device
EP2985007B1 (en) 2011-12-22 2019-11-13 Cook Medical Technologies LLC Preloaded wire for endoluminal device
WO2013119630A1 (en) 2012-02-06 2013-08-15 Cook Medical Technologies Llc Artificial device deployment apparatus
US10940167B2 (en) 2012-02-10 2021-03-09 Cvdevices, Llc Methods and uses of biological tissues for various stent and other medical applications
US9504458B2 (en) 2012-02-17 2016-11-29 Cook Biotech Incorporated Methods and systems for treating complex fistulae
US9308107B2 (en) 2012-08-27 2016-04-12 Cook Medical Technologies Llc Endoluminal prosthesis and delivery device
US20140121750A1 (en) 2012-10-31 2014-05-01 Cook Medical Technologies Llc Fixation Process For Nesting Stents
US9669190B2 (en) * 2012-11-28 2017-06-06 Cook Medical Technologies Llc Selectively positionable catheter cuff
EP2745813A1 (en) 2012-12-18 2014-06-25 Cook Medical Technologies LLC Preloaded wire for endoluminal device
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
US9861466B2 (en) 2012-12-31 2018-01-09 Cook Medical Technologies Llc Endoluminal prosthesis
EP2953659B1 (en) 2013-02-08 2019-10-16 Acell, Inc. Methods of manufacturing bioactive gels from extracellular matrix material
AU2014214700B2 (en) 2013-02-11 2018-01-18 Cook Medical Technologies Llc Expandable support frame and medical device
EP2964162B1 (en) 2013-03-07 2018-01-17 Cook Medical Technologies LLC Tissue ingrowth intestinal bypass sleeve
US9993330B2 (en) 2013-03-13 2018-06-12 Cook Medical Technologies Llc Endoluminal prosthesis system
US11065368B2 (en) 2013-03-15 2021-07-20 Cook Biotech Incorporated Drug eluting graft constructs and methods
US10973856B2 (en) 2013-03-15 2021-04-13 Cook Biotech Incorporated ECM implant compositions and methods
PL2983616T3 (en) 2013-04-08 2019-05-31 Regentys Corp Method and composition for treating inflammatory bowel disease without colectomy
US9861662B2 (en) 2013-07-03 2018-01-09 University of Pittsburgh—of the Commonwealth System of Higher Education Bone-derived extra cellular matrix gel
CA2919504A1 (en) 2013-08-01 2015-02-05 Christine BRONIKOWSKI Tissue adjustment implant
US20150080940A1 (en) 2013-09-13 2015-03-19 Cook Medical Technologies Llc Anti-tumor macrophage m1 morphology inducer
US9878071B2 (en) 2013-10-16 2018-01-30 Purdue Research Foundation Collagen compositions and methods of use
EP2893884A1 (en) 2014-01-08 2015-07-15 Cook Medical Technologies LLC ECM strip to plug percutaneous heart valve leaks
US10286119B2 (en) 2014-01-24 2019-05-14 University of Pittsburgh—of the Commonwealth System of Higher Education Extracellular matrix mesh coating
JP6681872B2 (en) 2014-03-21 2020-04-15 ユニバーシティ オブ ピッツバーグ −オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション Method for preparing final sterile hydrogel derived from extracellular matrix
EP2988130A1 (en) 2014-08-20 2016-02-24 Eppendorf Ag Method for coating a solid support
EP3197513B1 (en) 2014-09-25 2023-08-02 Acell, Inc. Porous foams derived from extracellular matrix, porous foam ecm medical devices, and methods of use and making thereof
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
US10183152B2 (en) 2014-12-12 2019-01-22 Cook Medical Technologies Llc Cinching peritoneal dialysis catheter
NZ732814A (en) 2014-12-22 2023-12-22 Aroa Biosurgery Ltd Laminated tissue graft product
US9238090B1 (en) 2014-12-24 2016-01-19 Fettech, Llc Tissue-based compositions
US10583004B2 (en) 2015-02-27 2020-03-10 University of Pittsburgh — Of the Commonwealth System of Higher Education Retrievable self-expanding non-thrombogenic low-profile percutaneous atrioventricular valve prosthesis
US11129711B2 (en) 2015-02-27 2021-09-28 University of Pittsburgh—of the Commonwealth System of Higher Education Double component mandrel for electrospun stentless, multi-leaflet valve fabrication
WO2016172365A1 (en) 2015-04-21 2016-10-27 Purdue Research Foundation Office Of Technology Commercialization Cell-collagen-silica composites and methods of making and using the same
RU2610000C2 (en) * 2015-07-24 2017-02-07 Федеральное государственное бюджетное учреждение "Государственный научный центр Российской Федерации - Федеральный медицинский биофизический центр имени А.И. Бурназяна" Method of residual urinary incontinence treatment after implantation of artificial urinary sphincter
US10736991B2 (en) 2015-09-18 2020-08-11 University of Pittsburgh—of the Commonwealth System of Higher Education Non-gelling soluble extracellular matrix with biological activity
US10173027B2 (en) 2015-10-07 2019-01-08 Cook Medical Technologies Llc Methods, medical devices and kits for modifying the luminal profile of a body vessel
US20190046211A1 (en) 2015-12-02 2019-02-14 Cook Biotech Incorporated Filamentous graft implants and methods of their manufacture and use
WO2017100625A2 (en) 2015-12-10 2017-06-15 Cook Biotech Incorporated Poly(ester urea) fiber devices and related methods
WO2017151862A1 (en) 2016-03-02 2017-09-08 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Matrix bound nanovesicles and their use
US11389566B2 (en) * 2016-03-14 2022-07-19 Regentys Corporation Method and composition for treating inflammatory bowel disease
US11331348B2 (en) 2016-04-28 2022-05-17 University of Pittsburgh—of the Commonwealth System of Higher Education Compositions comprising extracellular matrix of primitive animal species and related methods
EP3269328A3 (en) 2016-06-08 2018-01-24 Cook Medical Technologies LLC Cardiac valve implant
WO2018017611A1 (en) 2016-07-18 2018-01-25 Cook Biotech Incorporated Implantable pouch with segmental lamination structure, and related methods of manufacture and use
US20180071526A1 (en) 2016-09-10 2018-03-15 Cook Biotech Incorporated Electrostimulative graft products, and related methods of use and manufacture
US11191632B2 (en) 2016-11-10 2021-12-07 Cook Medical Technologies Llc Temporary diameter reduction constraint arrangement for a stent graft in combination with a stent graft
EP3320881B1 (en) 2016-11-10 2019-09-04 Cook Medical Technologies LLC Diameter reduction constraint arrangement for a stent graft in combination with a stent graft
EP3585313A4 (en) 2017-02-23 2020-12-30 University of Pittsburgh - of The Commonwealth System of Higher Education Stentless biopolymer heart valve replacement capable of living tissue regeneration
EP3589294B1 (en) 2017-03-02 2022-10-26 University of Pittsburgh - Of the Commonwealth System of Higher Education Extracellular matrix (ecm) hydrogel and soluble fraction thereof for use in the treatment of cancer
EP4252842A3 (en) 2017-03-02 2023-10-25 University of Pittsburgh- Of the Commonwealth System of Higher Education Ecm hydrogel for treating esophageal inflammation
US11389569B2 (en) 2017-04-03 2022-07-19 University of Pittsburgh—of the Commonwealth System of Higher Education Biodegradable, porous, thermally responsive injectable hydrogel as soft tissue defect filler
EP3615568A4 (en) 2017-04-25 2021-01-20 Purdue Research Foundation 3-dimensional (3d) tissue-engineered muscle for tissue restoration
KR20190141775A (en) 2017-05-05 2019-12-24 유니버시티 오브 피츠버그 - 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 Application to the eye of a substrate-bound vesicle
WO2019006218A1 (en) 2017-06-29 2019-01-03 Oconnor Peter Implantable medical devices for tissue repositioning
WO2019079195A1 (en) 2017-10-16 2019-04-25 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Genetically modified mesenchymal stem cells for use in cardiovascular prosthetics
AU2018214103B1 (en) 2018-08-09 2018-10-04 Cook Medical Technologies Llc A stent-graft
JP2022513073A (en) 2018-11-19 2022-02-07 ザ ユナイテッド ステイツ オブ アメリカ アズ リプリゼンテッド バイ ザ セクレタリー、デパートメント オブ ヘルス アンド ヒューマン サービシーズ Biodegradable tissue replacement implants and their use
CA3130684A1 (en) 2019-03-13 2020-09-17 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Acoustic extracellular matrix hydrogels and their use
WO2021185728A1 (en) 2020-03-16 2021-09-23 Biosearch, S.A. Biocomposites comprising probiotics, collagen and bacterial extracellular polysaccharide and uses thereof
AU2021315935A1 (en) 2020-07-27 2023-03-30 Cook Biotech Incorporated Adhesive for surgical staple line reinforcement
US11849951B2 (en) 2020-07-27 2023-12-26 Cook Biotech Incorporated System and methods for supplying surgical staple line reinforcement
US11826490B1 (en) 2020-12-29 2023-11-28 Acell, Inc. Extracellular matrix sheet devices with improved mechanical properties and method of making
EP4347795A1 (en) 2021-05-28 2024-04-10 The United States of America, as represented by The Secretary, Department of Health and Human Services Methods to generate macular, central and peripheral retinal pigment epithelial cells
CA3220433A1 (en) 2021-05-28 2022-12-01 Arvydas Maminishkis Biodegradable tissue scaffold with secondary matrix to host weakly adherent cells
WO2023215883A1 (en) 2022-05-05 2023-11-09 Cook Biotech Incorporated Photocrosslinkable synthetic polymers
WO2023215885A1 (en) 2022-05-05 2023-11-09 Cook Biotech Incorporated Subtissue implant material

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4902508A (en) * 1988-07-11 1990-02-20 Purdue Research Foundation Tissue graft composition
US4956178A (en) * 1988-07-11 1990-09-11 Purdue Research Foundation Tissue graft composition
SU1644914A1 (en) * 1989-03-24 1991-04-30 Научно-Исследовательский Институт Педиатрии Амн Ссср Infant uretheroneocystostomy method
US5281422A (en) * 1991-09-24 1994-01-25 Purdue Research Foundation Graft for promoting autogenous tissue growth
WO1993007913A1 (en) * 1991-10-24 1993-04-29 Children's Medical Center Corporation Neomorphogenesis of urological structures in vivo from cell culture
US5275826A (en) * 1992-11-13 1994-01-04 Purdue Research Foundation Fluidized intestinal submucosa and its use as an injectable tissue graft
US5352463A (en) * 1992-11-13 1994-10-04 Badylak Steven F Tissue graft for surgical reconstruction of a collagenous meniscus and method therefor

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US5554389A (en) 1996-09-10

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