CA2218873A1 - Electrotransport agent delivery method and apparatus - Google Patents

Electrotransport agent delivery method and apparatus

Info

Publication number
CA2218873A1
CA2218873A1 CA002218873A CA2218873A CA2218873A1 CA 2218873 A1 CA2218873 A1 CA 2218873A1 CA 002218873 A CA002218873 A CA 002218873A CA 2218873 A CA2218873 A CA 2218873A CA 2218873 A1 CA2218873 A1 CA 2218873A1
Authority
CA
Canada
Prior art keywords
electrotransport
agent delivery
delivery method
msec
electrotransport agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002218873A
Other languages
French (fr)
Other versions
CA2218873C (en
Inventor
J. Bradley Phipps
Gary A. Lattin
Ronald P. Haak
Felix Theeuwes
Suneel Gupta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corporation
J. Bradley Phipps
Gary A. Lattin
Ronald P. Haak
Felix Theeuwes
Suneel Gupta
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corporation, J. Bradley Phipps, Gary A. Lattin, Ronald P. Haak, Felix Theeuwes, Suneel Gupta filed Critical Alza Corporation
Publication of CA2218873A1 publication Critical patent/CA2218873A1/en
Application granted granted Critical
Publication of CA2218873C publication Critical patent/CA2218873C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432—Anode and cathode
    • A61N1/044—Shape of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0448—Drug reservoir

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Electrotherapy Devices (AREA)
  • Medicinal Preparation (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

An electrotransport agent delivery device (10) for delivering a therapeutic agent through intact skin, and a method of operating same, is provided. The device applies a pulsing electrotransport current wherein the length of the applied current pulses is at least 5 msec and preferably at least 10 msec. Most preferably, the current pulses have a magnitude above a critical level (I c) at which the skin is transformed into a higher electrotransport delivery efficiency (E) state.
CA002218873A 1995-06-07 1996-06-07 Electrotransport agent delivery method and apparatus Expired - Fee Related CA2218873C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/483,069 US5983130A (en) 1995-06-07 1995-06-07 Electrotransport agent delivery method and apparatus
US08/483,069 1995-06-07
PCT/US1996/010128 WO1996040365A1 (en) 1995-06-07 1996-06-07 Electrotransport agent delivery method and apparatus

Publications (2)

Publication Number Publication Date
CA2218873A1 true CA2218873A1 (en) 1996-12-19
CA2218873C CA2218873C (en) 2007-09-04

Family

ID=23918516

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002218873A Expired - Fee Related CA2218873C (en) 1995-06-07 1996-06-07 Electrotransport agent delivery method and apparatus

Country Status (15)

Country Link
US (2) US5983130A (en)
EP (2) EP0836512B1 (en)
JP (2) JPH11507280A (en)
KR (2) KR100482229B1 (en)
CN (2) CN1104264C (en)
AT (2) ATE260691T1 (en)
AU (2) AU694371B2 (en)
BR (2) BR9608600A (en)
CA (1) CA2218873C (en)
DE (2) DE69623964T2 (en)
DK (3) DK0836512T3 (en)
ES (2) ES2183962T3 (en)
MX (1) MX9709643A (en)
PT (1) PT836513E (en)
WO (2) WO1996040365A1 (en)

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Also Published As

Publication number Publication date
EP0836513B1 (en) 2002-09-25
EP0836512A1 (en) 1998-04-22
DK140997A (en) 1997-12-05
AU701238B2 (en) 1999-01-21
WO1996040364A1 (en) 1996-12-19
MX9709643A (en) 1998-07-31
EP0836513A1 (en) 1998-04-22
US7212853B1 (en) 2007-05-01
CN1104264C (en) 2003-04-02
DK140897A (en) 1997-12-05
KR19990022484A (en) 1999-03-25
CN1187144A (en) 1998-07-08
AU6271296A (en) 1996-12-30
EP0836512B1 (en) 2004-03-03
AU6275096A (en) 1996-12-30
DE69623964D1 (en) 2002-10-31
DE69631766T2 (en) 2004-07-29
JPH11507274A (en) 1999-06-29
ATE224753T1 (en) 2002-10-15
KR19990022485A (en) 1999-03-25
PT836513E (en) 2002-12-31
AU694371B2 (en) 1998-07-16
ES2183962T3 (en) 2003-04-01
JPH11507280A (en) 1999-06-29
ES2217320T3 (en) 2004-11-01
CN1095682C (en) 2002-12-11
DE69623964T2 (en) 2003-06-05
ATE260691T1 (en) 2004-03-15
WO1996040365A1 (en) 1996-12-19
CA2218873C (en) 2007-09-04
BR9609245A (en) 1999-05-18
KR100482229B1 (en) 2005-06-16
DK0836512T3 (en) 2004-03-29
BR9608600A (en) 1999-01-05
MX9709641A (en) 1998-07-31
CN1187143A (en) 1998-07-08
KR100472689B1 (en) 2005-06-16
US5983130A (en) 1999-11-09
DE69631766D1 (en) 2004-04-08

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