CA2220306A1 - Bone substitution material and a method of its manufacture - Google Patents

Bone substitution material and a method of its manufacture

Info

Publication number
CA2220306A1
CA2220306A1 CA002220306A CA2220306A CA2220306A1 CA 2220306 A1 CA2220306 A1 CA 2220306A1 CA 002220306 A CA002220306 A CA 002220306A CA 2220306 A CA2220306 A CA 2220306A CA 2220306 A1 CA2220306 A1 CA 2220306A1
Authority
CA
Canada
Prior art keywords
amorphous
solids
manufacture
poorly
provides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002220306A
Other languages
French (fr)
Other versions
CA2220306C (en
Inventor
Dosuk D. Lee
Christian Rey
Maria Aiolova
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Etex Corp
Original Assignee
Etex Corporation
Dosuk D. Lee
Christian Rey
Maria Aiolova
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Etex Corporation, Dosuk D. Lee, Christian Rey, Maria Aiolova filed Critical Etex Corporation
Publication of CA2220306A1 publication Critical patent/CA2220306A1/en
Application granted granted Critical
Publication of CA2220306C publication Critical patent/CA2220306C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B28/00—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements
    • C04B28/34—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders
    • C04B28/344—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders the phosphate binder being present in the starting composition solely as one or more phosphates
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B25/00—Phosphorus; Compounds thereof
    • C01B25/16—Oxyacids of phosphorus; Salts thereof
    • C01B25/26—Phosphates
    • C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30756—Cartilage endoprostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A61L27/425—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of phosphorus containing material, e.g. apatite
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B25/00—Phosphorus; Compounds thereof
    • C01B25/16—Oxyacids of phosphorus; Salts thereof
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B25/00—Phosphorus; Compounds thereof
    • C01B25/16—Oxyacids of phosphorus; Salts thereof
    • C01B25/26—Phosphates
    • C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
    • C01B25/321—Methods for converting an alkaline earth metal ortho-phosphate into another ortho-phosphate
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B25/00—Phosphorus; Compounds thereof
    • C01B25/16—Oxyacids of phosphorus; Salts thereof
    • C01B25/26—Phosphates
    • C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
    • C01B25/325—Preparation by double decomposition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30756—Cartilage endoprostheses
    • A61F2002/30762—Means for culturing cartilage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
    • A61F2/4644—Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material
    • A61F2002/4648—Means for culturing bone graft
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2111/00—Mortars, concrete or artificial stone or mixtures to prepare them, characterised by specific function, property or use
    • C04B2111/00474—Uses not provided for elsewhere in C04B2111/00
    • C04B2111/00836—Uses not provided for elsewhere in C04B2111/00 for medical or dental applications
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
    • Y10S977/775—Nanosized powder or flake, e.g. nanosized catalyst
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
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    • Y10S977/779—Possessing nanosized particles, powders, flakes, or clusters other than simple atomic impurity doping
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/926—Topical chemical, e.g. cosmetic or sunscreen

Abstract

The present invention provides a process for converting a standard inert amorphous calcium phosphate precipitate into highly reactive amorphous solids. The amorphous solids can be used to react with other calcium phosphate solids to form a poorly-crystalline synthetic hydroxyapatite that provides both bioactivity and structural integrity. This novel amorphous material can be reacted with other calcium phosphates at or below 37 °C to form a bone-like material consisting of poorly cyrstalline hydroxyapatite.
CA002220306A 1995-05-19 1996-05-20 Bone substitution material and a method of its manufacture Expired - Lifetime CA2220306C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/446,182 1995-05-19
US08/446,182 US5676976A (en) 1995-05-19 1995-05-19 Synthesis of reactive amorphous calcium phosphates
PCT/US1996/007273 WO1996036562A1 (en) 1995-05-19 1996-05-20 Bone substitution material and a method of its manufacture

Publications (2)

Publication Number Publication Date
CA2220306A1 true CA2220306A1 (en) 1996-11-21
CA2220306C CA2220306C (en) 2008-07-29

Family

ID=23771613

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002220306A Expired - Lifetime CA2220306C (en) 1995-05-19 1996-05-20 Bone substitution material and a method of its manufacture

Country Status (17)

Country Link
US (4) US5676976A (en)
EP (2) EP1787954A3 (en)
JP (1) JP4260880B2 (en)
KR (1) KR100444343B1 (en)
CN (1) CN1184454A (en)
AU (1) AU711326B2 (en)
BR (1) BR9608409A (en)
CA (1) CA2220306C (en)
CZ (1) CZ362697A3 (en)
EA (1) EA000309B1 (en)
FI (1) FI974210A (en)
HU (1) HUP9901130A3 (en)
NO (1) NO975247L (en)
NZ (1) NZ308816A (en)
PL (1) PL323448A1 (en)
TR (1) TR199701392T2 (en)
WO (1) WO1996036562A1 (en)

Families Citing this family (235)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962028A (en) 1988-04-20 1999-10-05 Norian Corporation Carbonated hydroxyapatite compositions and uses
GB9215356D0 (en) * 1992-07-20 1992-09-02 Univ Reading The Bone materials
ES2268696T3 (en) * 1994-11-08 2007-03-16 Avicena Group, Inc. USE OF CREATINE OR CREATINE ANALOGS FOR THE TREATMENT OF HUNTIGTON'S DISEASE, PARKINSON'S DISEASE AND AMIOTROPHIC SIDE STERHERISIS.
US6287341B1 (en) * 1995-05-19 2001-09-11 Etex Corporation Orthopedic and dental ceramic implants
US6027742A (en) * 1995-05-19 2000-02-22 Etex Corporation Bioresorbable ceramic composites
US5676976A (en) * 1995-05-19 1997-10-14 Etex Corporation Synthesis of reactive amorphous calcium phosphates
US7150879B1 (en) 1995-05-19 2006-12-19 Etex Corporation Neutral self-setting calcium phosphate paste
US6117456A (en) * 1995-05-19 2000-09-12 Etex Corporation Methods and products related to the physical conversion of reactive amorphous calcium phosphate
US6132463A (en) * 1995-05-19 2000-10-17 Etex Corporation Cell seeding of ceramic compositions
US8333996B2 (en) * 1995-05-19 2012-12-18 Etex Corporation Calcium phosphate delivery vehicle and adjuvant
US6541037B1 (en) 1995-05-19 2003-04-01 Etex Corporation Delivery vehicle
US5783217A (en) * 1995-11-07 1998-07-21 Etex Corporation Low temperature calcium phosphate apatite and a method of its manufacture
JP4040705B2 (en) * 1996-01-24 2008-01-30 株式会社サンギ Oral composition
US6855749B1 (en) * 1996-09-03 2005-02-15 Nanoproducts Corporation Polymer nanocomposite implants with enhanced transparency and mechanical properties for administration within humans or animals
US6933331B2 (en) * 1998-05-22 2005-08-23 Nanoproducts Corporation Nanotechnology for drug delivery, contrast agents and biomedical implants
US6652967B2 (en) * 2001-08-08 2003-11-25 Nanoproducts Corporation Nano-dispersed powders and methods for their manufacture
US6953594B2 (en) 1996-10-10 2005-10-11 Etex Corporation Method of preparing a poorly crystalline calcium phosphate and methods of its use
WO1998016268A2 (en) * 1996-10-16 1998-04-23 Etex Corporation Method of preparing a poorly crystalline calcium phosphate and methods of its use
US7517539B1 (en) 1996-10-16 2009-04-14 Etex Corporation Method of preparing a poorly crystalline calcium phosphate and methods of its use
US8728536B2 (en) * 1996-10-16 2014-05-20 Etex Corporation Chemotherapeutic composition using nanocrystalline calcium phosphate paste
JP4260891B2 (en) * 1996-10-16 2009-04-30 エテックス コーポレイション Bioceramic composition
US6037519A (en) * 1997-10-20 2000-03-14 Sdgi Holdings, Inc. Ceramic fusion implants and compositions
DE19713229A1 (en) * 1997-04-01 1998-10-08 Merck Patent Gmbh Bone cement paste containing antibiotics
DE19721661A1 (en) 1997-05-23 1998-11-26 Zimmer Markus Bone and cartilage replacement structures
US5951160A (en) * 1997-11-20 1999-09-14 Biomet, Inc. Method and apparatus for packaging, mixing and delivering bone cement
US7147666B1 (en) * 1997-11-26 2006-12-12 Bernard Francis Grisoni Monolithic implants with openings
CN1058689C (en) * 1998-02-05 2000-11-22 华东理工大学 Porous calcium phosphate cement containing pore-creating agent
US6139585A (en) * 1998-03-11 2000-10-31 Depuy Orthopaedics, Inc. Bioactive ceramic coating and method
US6736849B2 (en) 1998-03-11 2004-05-18 Depuy Products, Inc. Surface-mineralized spinal implants
DE19816858A1 (en) 1998-04-16 1999-10-21 Merck Patent Gmbh Tricalcium phosphate-containing bio-cement pastes with cohesion promoters
JP4254057B2 (en) * 1998-05-08 2009-04-15 日油株式会社 Method for producing hydroxyapatite and method for producing composite
US6083264A (en) * 1998-06-30 2000-07-04 Mcdonnell Douglas Corporation Implant material for replacing or augmenting living bone tissue involving thermoplastic syntactic foam
US5968253A (en) * 1998-07-31 1999-10-19 Norian Corporation Calcium phosphate cements comprising antimicrobial agents
US6383519B1 (en) * 1999-01-26 2002-05-07 Vita Special Purpose Corporation Inorganic shaped bodies and methods for their production and use
US20040258763A1 (en) * 1999-02-03 2004-12-23 Bell Steve J.D. Methods of manufacture and use of calcium phosphate particles containing allergens
AU2753100A (en) 1999-02-03 2000-08-25 Biosante Pharmaceuticals, Inc. Therapeutic calcium phosphate particles and methods of manufacture and use
US7094282B2 (en) * 2000-07-13 2006-08-22 Calcitec, Inc. Calcium phosphate cement, use and preparation thereof
US7270705B2 (en) * 1999-07-14 2007-09-18 Jiin-Huey Chern Lin Method of increasing working time of tetracalcium phosphate cement paste
US7169373B2 (en) * 1999-07-14 2007-01-30 Calcitec, Inc. Tetracalcium phosphate (TTCP) having calcium phosphate whisker on surface and process for preparing the same
US6840995B2 (en) * 1999-07-14 2005-01-11 Calcitec, Inc. Process for producing fast-setting, bioresorbable calcium phosphate cements
US6960249B2 (en) 1999-07-14 2005-11-01 Calcitec, Inc. Tetracalcium phosphate (TTCP) having calcium phosphate whisker on surface
US6458162B1 (en) 1999-08-13 2002-10-01 Vita Special Purpose Corporation Composite shaped bodies and methods for their production and use
ES2491866T3 (en) 1999-11-15 2014-09-08 Piramal Healthcare (Canada) Limited Temperature-controlled, pH-dependent, self-gelling aqueous biopolymer solution
US20030158302A1 (en) * 1999-12-09 2003-08-21 Cyric Chaput Mineral-polymer hybrid composition
AU2432501A (en) * 1999-12-28 2001-07-09 Osteotech, Inc. Calcium phosphate bone graft material and osteoimplant fabricated therefrom
AU2001231264A1 (en) 2000-01-31 2001-08-07 Advanced Research And Technology Institute, Inc. Composite biomaterial including anisometric calcium phosphate reinforcement particles and related methods
US7204876B2 (en) 2000-07-13 2007-04-17 Calcitec, Inc. Calcium phosphate cements made from (TTCP) with surface whiskers and process for preparing same
US7156915B2 (en) 2000-07-13 2007-01-02 Calcitec, Inc. Tetracalcium phosphate (TTCP) with surface whiskers and method of making same
US6599516B1 (en) * 2000-09-14 2003-07-29 Etex Corporation Malleable implant containing solid element that resorbs or fractures to provide access channels
AU2002248289A1 (en) * 2000-10-20 2002-09-04 Etex Corporation Chemotherapeutic composition using calcium phosphate paste
ATE417577T1 (en) * 2000-10-24 2009-01-15 Warsaw Orthopedic Inc DEVICES FOR SPINAL FUSION
AU2002220069B2 (en) * 2000-10-24 2005-12-15 Warsaw Orthopedic, Inc. Methods and instruments for treating pseudoarthrosis
US6648894B2 (en) * 2000-12-21 2003-11-18 Stryker Spine Bone graft forming guide and method of forming bone grafts
US20020114795A1 (en) 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
US20060062855A1 (en) * 2001-02-27 2006-03-23 Bell Steve J D Therapeutic calcium phosphate particles for use in inhibiting expression of a gene
WO2002083194A1 (en) * 2001-04-12 2002-10-24 Therics, Inc. Method and apparatus for engineered regenerative biostructures
US20050177237A1 (en) * 2001-04-12 2005-08-11 Ben Shappley Spinal cage insert, filler piece and method of manufacturing
CA2449008A1 (en) * 2001-06-01 2002-12-12 Wyeth Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins
US8740987B2 (en) * 2001-06-04 2014-06-03 Warsaw Orthopedic, Inc. Tissue-derived mesh for orthopedic regeneration
TWI267378B (en) * 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
US20030026770A1 (en) * 2001-07-25 2003-02-06 Szymaitis Dennis W. Periodontal regeneration composition and method of using same
US7105182B2 (en) * 2001-07-25 2006-09-12 Szymaitis Dennis W Periodontal regeneration composition and method of using same
US6855426B2 (en) * 2001-08-08 2005-02-15 Nanoproducts Corporation Methods for producing composite nanoparticles
JP4204772B2 (en) * 2001-08-30 2009-01-07 独立行政法人科学技術振興機構 Method for producing in vivo drug sustained release material
US20030130171A1 (en) * 2001-10-30 2003-07-10 Schoenhard Grant L. Inhibitors of ABC drug transporters in multidrug resistant microbial cells
WO2003043673A1 (en) 2001-11-19 2003-05-30 Scil Technology Gmbh Device having osteoinductive and osteoconductive properties
US6478825B1 (en) 2001-11-28 2002-11-12 Osteotech, Inc. Implant, method of making same and use of the implant for the treatment of bone defects
WO2003055418A1 (en) * 2001-12-21 2003-07-10 Lagow Richard J Calcium phosphate bone replacement materials and methods of use thereof
WO2003057137A2 (en) * 2001-12-21 2003-07-17 Etex Corporation Synthesis of calcium phosphates by mechano-chemical process
US6840961B2 (en) * 2001-12-21 2005-01-11 Etex Corporation Machinable preformed calcium phosphate bone substitute material implants
US20040127563A1 (en) * 2002-03-22 2004-07-01 Deslauriers Richard J. Methods of performing medical procedures which promote bone growth, compositions which promote bone growth, and methods of making such compositions
US7776600B2 (en) 2002-04-18 2010-08-17 Carnegie Mellon University Method of manufacturing hydroxyapatite and uses therefor in delivery of nucleic acids
AU2003218271A1 (en) * 2002-04-18 2003-11-03 Carnegie Mellon University Method of manufacturing hydroxyapatite and uses therefor in delivery of nucleic acids
US20040115153A1 (en) * 2002-12-17 2004-06-17 L'oreal Compositions containing at least one oil structured with at least one silicone-polyamide polymer, and at least one silicone gum and methods of using the same
US6793678B2 (en) 2002-06-27 2004-09-21 Depuy Acromed, Inc. Prosthetic intervertebral motion disc having dampening
JP5449638B2 (en) * 2002-07-31 2014-03-19 デンツプライ インターナショナル インコーポレーテッド Bone repair putty comprising porous particles and carrier gel
US8876532B2 (en) 2002-07-31 2014-11-04 Dentsply International Inc. Bone repair putty
US8771719B2 (en) * 2002-08-12 2014-07-08 Warsaw Orthopedic, Inc. Synthesis of a bone-polymer composite material
EP1539261B1 (en) 2002-09-10 2006-04-12 Scil Technology GmbH Metal implant coated under reduced oxygen concentration with osteoinductive protein
US7018415B1 (en) 2002-09-23 2006-03-28 Sdgi Holdings, Inc. Expandable spinal fusion device and methods of promoting spinal fusion
GB0222291D0 (en) * 2002-09-26 2002-10-30 Smith & Nephew Adhesive bone cement
IL153699A (en) 2002-12-26 2008-11-26 Prochon Biotech Ltd Bone graft composite
US7708974B2 (en) * 2002-12-10 2010-05-04 Ppg Industries Ohio, Inc. Tungsten comprising nanomaterials and related nanotechnology
US20050251267A1 (en) * 2004-05-04 2005-11-10 John Winterbottom Cell permeable structural implant
US20040141903A1 (en) * 2003-01-17 2004-07-22 Howmedica Osteonics Corp. Calcium phosphate cement precursors
FR2850282B1 (en) * 2003-01-27 2007-04-06 Jerome Asius INJECTABLE IMPLANT BASED ON CERAMIC FOR THE FILLING OF WRINKLES, CUTANEOUS DEPRESSIONS AND SCARS, AND ITS PREPARATION
US7985414B2 (en) * 2003-02-04 2011-07-26 Warsaw Orthopedic, Inc. Polyurethanes for osteoimplants
AU2004209554B2 (en) 2003-02-04 2010-08-12 Warsaw Orthopedic, Inc. Polyurethanes for osteoimplants
US20040170692A1 (en) * 2003-02-12 2004-09-02 The Curators Of The University Of Missouri Calcium phosphate bodies and a process for making calcium phosphate bodies
AU2004212942A1 (en) 2003-02-14 2004-09-02 Depuy Spine, Inc. In-situ formed intervertebral fusion device
US20040180091A1 (en) * 2003-03-13 2004-09-16 Chang-Yi Lin Carbonated hydroxyapatite-based microspherical composites for biomedical uses
GB0307011D0 (en) 2003-03-27 2003-04-30 Regentec Ltd Porous matrix
CA2521623C (en) * 2003-04-11 2015-03-17 Etex Corporation Osteoinductive bone material
US20040250729A1 (en) * 2003-06-16 2004-12-16 Jang Bor Z. Fast-setting carbonated hydroxyapatite compositions and uses
US20040267367A1 (en) 2003-06-30 2004-12-30 Depuy Acromed, Inc Intervertebral implant with conformable endplate
US20050020506A1 (en) * 2003-07-25 2005-01-27 Drapeau Susan J. Crosslinked compositions comprising collagen and demineralized bone matrix, methods of making and methods of use
US7118705B2 (en) * 2003-08-05 2006-10-10 Calcitec, Inc. Method for making a molded calcium phosphate article
US6994726B2 (en) 2004-05-25 2006-02-07 Calcitec, Inc. Dual function prosthetic bone implant and method for preparing the same
US7163651B2 (en) 2004-02-19 2007-01-16 Calcitec, Inc. Method for making a porous calcium phosphate article
US8029755B2 (en) 2003-08-06 2011-10-04 Angstrom Medica Tricalcium phosphates, their composites, implants incorporating them, and method for their production
EP1675608B1 (en) 2003-09-12 2007-03-21 Wyeth Injectable calcium phosphate solid rods for delivery of osteogenic proteins
US20050085922A1 (en) * 2003-10-17 2005-04-21 Shappley Ben R. Shaped filler for implantation into a bone void and methods of manufacture and use thereof
EP1686934B1 (en) * 2003-11-07 2020-03-18 Vivex Biologics Group, Inc. Injectable bone substitute
US20050136764A1 (en) 2003-12-18 2005-06-23 Sherman Michael C. Designed composite degradation for spinal implants
US8012210B2 (en) * 2004-01-16 2011-09-06 Warsaw Orthopedic, Inc. Implant frames for use with settable materials and related methods of use
JP2007519492A (en) * 2004-01-30 2007-07-19 オステオテック，インコーポレイテッド Stacked implant for spinal fusion
US7189263B2 (en) 2004-02-03 2007-03-13 Vita Special Purpose Corporation Biocompatible bone graft material
US7351280B2 (en) * 2004-02-10 2008-04-01 New York University Macroporous, resorbable and injectible calcium phosphate-based cements (MCPC) for bone repair, augmentation, regeneration, and osteoporosis treatment
JP2007533376A (en) 2004-04-15 2007-11-22 エテックス コーポレーション Delayed solidification calcium phosphate paste
US7758896B2 (en) * 2004-04-16 2010-07-20 University Of Massachusetts Porous calcium phosphate networks for synthetic bone material
US9220595B2 (en) * 2004-06-23 2015-12-29 Orthovita, Inc. Shapeable bone graft substitute and instruments for delivery thereof
US7473678B2 (en) * 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
JP2008518956A (en) 2004-11-01 2008-06-05 バイオサンテ ファーマシューティカルズ，インコーポレイティド Therapeutic calcium phosphate and its manufacturing method and use in use for cosmetics or cosmetics
US7472576B1 (en) 2004-11-17 2009-01-06 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Portland State University Nanometrology device standards for scanning probe microscopes and processes for their fabrication and use
US20060110422A1 (en) * 2004-11-19 2006-05-25 Tas Ahmet C Conversion of calcite powders into macro- and microporous calcium phosphate scaffolds for medical applications
MD2856G2 (en) * 2005-03-29 2006-04-30 Валериу ФАЛА Material for osteoplasty (variants)
MD2877G2 (en) * 2005-04-05 2006-05-31 Валериу ФАЛА Material for osteoplasty (variants)
AU2006249942B2 (en) * 2005-05-26 2011-07-07 Zimmer Dental, Inc. Prosthetic dental device
US8814567B2 (en) * 2005-05-26 2014-08-26 Zimmer Dental, Inc. Dental implant prosthetic device with improved osseointegration and esthetic features
US20060292090A1 (en) * 2005-06-22 2006-12-28 Deepak Sharma Oral care compositions, devices, and methods of using the same
US8562346B2 (en) 2005-08-30 2013-10-22 Zimmer Dental, Inc. Dental implant for a jaw with reduced bone volume and improved osseointegration features
JP5438967B2 (en) 2005-08-30 2014-03-12 ジマー デンタル， インコーポレイテッド Dental implant with improved osseointegration features
US8025903B2 (en) 2005-09-09 2011-09-27 Wright Medical Technology, Inc. Composite bone graft substitute cement and articles produced therefrom
CN103349793B (en) 2005-09-09 2016-02-10 阿格诺沃斯健康关爱公司 Composite bone graft substitute cement and the goods obtained by it
AU2006292224B2 (en) 2005-09-19 2013-08-01 Histogenics Corporation Cell-support matrix and a method for preparation thereof
EP1945249A2 (en) * 2005-11-01 2008-07-23 Novartis AG Compositions with antigens adsorbed to calcium phosphate
DK1951299T3 (en) 2005-11-04 2012-04-02 Novartis Vaccines & Diagnostic Influenza vaccines containing combinations of particulate adjuvants and immune enhancers
NZ571113A (en) 2005-11-17 2012-02-24 Biomimetic Therapeutics Inc Maxillofacial bone augmentation using rhpdgf-bb and a biocompatible matrix
US20070122445A1 (en) * 2005-11-28 2007-05-31 Shalaby Shalaby W Absorbable fatigue-enduring phosphate composites
CN100428963C (en) * 2005-11-30 2008-10-29 浙江大学 Preparation method of non-sizing nano-calcium phosphate powder for medical slow release metal ion
US8147860B2 (en) 2005-12-06 2012-04-03 Etex Corporation Porous calcium phosphate bone material
US8048443B2 (en) 2005-12-16 2011-11-01 Cerapedics, Inc. Pliable medical device and method of use
EP1976460A4 (en) 2006-01-19 2012-06-20 Warsaw Orthopedic Inc Injectable and moldable bone substitute materials
EP1976459A4 (en) * 2006-01-19 2012-06-20 Warsaw Orthopedic Inc Porous osteoimplant
CN101410022B (en) * 2006-02-03 2013-06-12 Wm.雷格利Jr.公司 Calcium phosphate salts in oral compositions suitable as a tooth remineralizing agent
EP2311505B1 (en) 2006-02-09 2013-11-06 BioMimetic Therapeutics, LLC Compositions and methods for treating bone
US8298528B2 (en) * 2006-04-17 2012-10-30 Hepacore Ltd. Methods for bone regeneration using endothelial progenitor cell preparations
US7838022B2 (en) * 2006-05-01 2010-11-23 Warsaw Orthopedic, Inc Malleable implants containing demineralized bone matrix
US20100209470A1 (en) * 2006-05-01 2010-08-19 Warsaw Orthopedic, Inc. An Indiana Corporation Demineralized bone matrix devices
US8506983B2 (en) * 2006-05-01 2013-08-13 Warsaw Orthopedic, Inc. Bone filler material
US7771741B2 (en) * 2006-05-01 2010-08-10 Warsaw Orthopedic, Inc Demineralized bone matrix devices
KR100786312B1 (en) * 2006-05-03 2007-12-17 박진우 Method for fabricating calcium phosphate and calcium phosphate fabricated by using the same
US9421302B2 (en) * 2006-05-26 2016-08-23 Baxter International Inc. Injectable fibrin composition for bone augmentation
WO2008002682A2 (en) 2006-06-29 2008-01-03 Orthovita, Inc. Bioactive bone graft substitute
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
US9642891B2 (en) 2006-06-30 2017-05-09 Biomimetic Therapeutics, Llc Compositions and methods for treating rotator cuff injuries
US8034110B2 (en) 2006-07-31 2011-10-11 Depuy Spine, Inc. Spinal fusion implant
GB0618963D0 (en) * 2006-09-26 2006-11-08 Ucl Business Plc Formulations and composites with reactive fillers
EP3181157B1 (en) 2006-11-03 2019-08-14 BioMimetic Therapeutics, LLC Compositions and methods for arthrodetic procedures
US8388626B2 (en) * 2006-11-08 2013-03-05 Warsaw Orthopedic, Inc. Methods of employing calcium phosphate cement compositions and osteoinductive proteins to effect vertebrae interbody fusion absent an interbody device
US8105382B2 (en) 2006-12-07 2012-01-31 Interventional Spine, Inc. Intervertebral implant
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
US20080195476A1 (en) * 2007-02-09 2008-08-14 Marchese Michael A Abandonment remarketing system
EP1958649A1 (en) * 2007-02-14 2008-08-20 Graftys Injectable calcium-phosphate cement releasing a bone resorption inhibitor
JP5553396B2 (en) * 2007-04-10 2014-07-16 株式会社サンギ Remineralization accelerator and oral composition
US8900307B2 (en) 2007-06-26 2014-12-02 DePuy Synthes Products, LLC Highly lordosed fusion cage
KR100944942B1 (en) 2007-07-09 2010-03-03 재단법인서울대학교산학협력재단 Low soluble amorphous calcium phosphate prepared on the solid surface and its preparation
CA2965384C (en) 2007-08-09 2021-06-22 The Board Of Regents Of The University Of Texas System Bi-layered bone-like scaffolds
EP2200523B1 (en) 2007-08-29 2014-05-14 Etex Corporation Bone cement mixing and delivery system and methods of use thereof
US9149345B2 (en) * 2007-08-30 2015-10-06 Zimmer Dental, Inc. Multiple root implant
US20090061002A1 (en) * 2007-09-05 2009-03-05 Venbrocks Rudolf A Calcium phospate based delivery of growth and differentiation factors to compromised bone
US9056150B2 (en) 2007-12-04 2015-06-16 Warsaw Orthopedic, Inc. Compositions for treating bone defects
AU2008339631B2 (en) * 2007-12-24 2014-07-24 Novartis Ag Assays for adsorbed influenza vaccines
CA2711900A1 (en) * 2008-01-09 2009-07-16 Oswestry Tissue Bank Ltd Bone repair composition and a method of making the same
CN101909548B (en) 2008-01-17 2014-07-30 斯恩蒂斯有限公司 An expandable intervertebral implant and associated method of manufacturing the same
US7943573B2 (en) 2008-02-07 2011-05-17 Biomimetic Therapeutics, Inc. Methods for treatment of distraction osteogenesis using PDGF
US8840913B2 (en) 2008-03-27 2014-09-23 Warsaw Orthopedic, Inc. Malleable multi-component implants and materials therefor
WO2009120969A2 (en) * 2008-03-28 2009-10-01 Osteotech, Inc. Bone anchors for orthopedic applications
WO2009124269A1 (en) 2008-04-05 2009-10-08 Synthes Usa, Llc Expandable intervertebral implant
AU2009236216B2 (en) * 2008-04-15 2015-05-21 Life Science Enterprises, Inc. Minimally invasive treatment of vertebra (MITV) using a calcium phosphate combination bone cement
US8899982B2 (en) 2008-07-02 2014-12-02 Zimmer Dental, Inc. Implant with structure for securing a porous portion
US9095396B2 (en) 2008-07-02 2015-08-04 Zimmer Dental, Inc. Porous implant with non-porous threads
US8231387B2 (en) 2008-07-02 2012-07-31 Zimmer, Inc. Porous implant with non-porous threads
US8562348B2 (en) 2008-07-02 2013-10-22 Zimmer Dental, Inc. Modular implant with secured porous portion
BR122020000059B8 (en) 2008-09-09 2021-06-22 Biomimetic Therapeutics Inc composition comprising a biocompatible matrix and a platelet-derived growth factor and kit
WO2012134540A2 (en) 2010-10-22 2012-10-04 Vanderbilt University Injectable synthetic pur composite
EP2358408A2 (en) * 2008-10-30 2011-08-24 Osteotech, Inc., Bone/polyurethane composites and methods thereof
US20100114314A1 (en) 2008-11-06 2010-05-06 Matthew Lomicka Expandable bone implant
FR2948573B1 (en) 2009-07-31 2011-11-18 Adocia NEW FORM OF ADMINISTRATION OF OSTEOGENIC PROTEIN COMPLEXES
US8894958B2 (en) 2009-03-03 2014-11-25 Centre National De La Recherche Scientifique (C.N.R.S.) Galliated calcium phosphate biomaterials
US8623311B2 (en) 2009-03-03 2014-01-07 Graftys Gallium-doped phosphocalcic compounds
EP2228080A1 (en) 2009-03-03 2010-09-15 Graftys Galliated calcium phosphate biomaterials
EP2403514A4 (en) * 2009-03-05 2012-11-14 Biomimetic Therapeutics Inc Platelet-derived growth factor compositions and methods for the treatment of osteochondral defects
US9526620B2 (en) 2009-03-30 2016-12-27 DePuy Synthes Products, Inc. Zero profile spinal fusion cage
US8734524B2 (en) 2009-06-23 2014-05-27 Geistlich Pharma Ag Bone substitute material
US9707058B2 (en) 2009-07-10 2017-07-18 Zimmer Dental, Inc. Patient-specific implants with improved osseointegration
FR2948572A1 (en) 2009-07-31 2011-02-04 Adocia NEW FORM OF ADMINISTRATION OF OSTEOGENIC PROTEINS
US20110046239A1 (en) * 2009-08-24 2011-02-24 Keiser Bruce A Calcium based carrier particles
US20110046240A1 (en) * 2009-08-24 2011-02-24 Keizer Timothy S Calcium-based carrier particles
US20110046238A1 (en) * 2009-08-24 2011-02-24 Keiser Bruce A Calcium based carrier particles
US20110046241A1 (en) * 2009-08-24 2011-02-24 Keizer Timothy S Calcium based carrier particles
US8574273B2 (en) 2009-09-09 2013-11-05 Innovision, Inc. Bone screws and methods of use thereof
FR2956116A1 (en) * 2010-02-09 2011-08-12 Adocia SOLUBLE POLYSACCHARIDE / BMP-7 COMPLEXES WITH PH PHYSIOLOGICAL PH
US8602782B2 (en) 2009-11-24 2013-12-10 Zimmer Dental, Inc. Porous implant device with improved core
US9168138B2 (en) 2009-12-09 2015-10-27 DePuy Synthes Products, Inc. Aspirating implants and method of bony regeneration
US9393129B2 (en) 2009-12-10 2016-07-19 DePuy Synthes Products, Inc. Bellows-like expandable interbody fusion cage
FR2958647B1 (en) * 2010-04-08 2013-08-23 Adocia POLYSACCHARIDES COMPRISING FUNCTIONAL CARBOXYL GROUPS SUBSTITUTED WITH A HYDROPHOBIC DERIVATIVE CARRIED BY AT LEAST TRIVALENT SPACER.
JP6144049B2 (en) 2010-02-22 2017-06-07 バイオミメティック セラピューティクス，リミテッド ライアビリティ カンパニー Platelet-derived growth factor compositions and methods for treating tendon disorders
RU2456253C2 (en) * 2010-06-24 2012-07-20 Государственное учебно-научное учреждение Факультет Наук о Материалах Московского Государственного Университета им. М.В. Ломоносова Method of preparing mixture for producing ceramic biodegradable material
US9907560B2 (en) 2010-06-24 2018-03-06 DePuy Synthes Products, Inc. Flexible vertebral body shavers
US8979860B2 (en) 2010-06-24 2015-03-17 DePuy Synthes Products. LLC Enhanced cage insertion device
TW201215379A (en) 2010-06-29 2012-04-16 Synthes Gmbh Distractible intervertebral implant
US9402732B2 (en) 2010-10-11 2016-08-02 DePuy Synthes Products, Inc. Expandable interspinous process spacer implant
CN103313733A (en) 2010-11-15 2013-09-18 捷迈整形外科生物材料有限公司 Bone void fillers
US10384069B2 (en) 2013-01-22 2019-08-20 Frederick R. Guy Tooth and bone restoration via plasma deposition
US11571584B2 (en) 2010-12-30 2023-02-07 Frederick R. Guy Tooth and bone restoration via plasma deposition
EP2688514A1 (en) 2011-03-21 2014-01-29 Endo Pharmaceuticals Inc. Urethral anastomosis device and method
US20130066327A1 (en) * 2011-09-09 2013-03-14 Håkan Engqvist Hydraulic cement compositions with low ph methods, articles and kits
WO2014047061A1 (en) 2012-09-18 2014-03-27 Endo Pharmaceuticals Inc. Urethral anastomosis device
US9522070B2 (en) 2013-03-07 2016-12-20 Interventional Spine, Inc. Intervertebral implant
WO2014159186A1 (en) 2013-03-14 2014-10-02 Endo Pharmaceuticals Inc. Urethral anastomosis device
AU2014237911B2 (en) 2013-03-15 2018-02-15 Innovision, Inc. Bone screws and methods of use thereof
TWI651103B (en) 2013-12-13 2019-02-21 萊特醫技股份有限公司 Multiphase bone graft replacement material
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
US10219986B2 (en) 2015-03-04 2019-03-05 Modern Ideas LLC Stabilized calcium phosphate and methods of forming same
US11426290B2 (en) 2015-03-06 2022-08-30 DePuy Synthes Products, Inc. Expandable intervertebral implant, system, kit and method
US10195305B2 (en) 2015-03-24 2019-02-05 Orthovita, Inc. Bioactive flowable wash-out resistant bone graft material and method for production thereof
US9956314B2 (en) 2016-01-26 2018-05-01 Modern Ideas LLC Adhesive for use with bone and bone-like structures
JP6995789B2 (en) 2016-06-28 2022-01-17 イーアイティー・エマージング・インプラント・テクノロジーズ・ゲーエムベーハー Expandable and angle adjustable intervertebral cage
JP7019616B2 (en) 2016-06-28 2022-02-15 イーアイティー・エマージング・インプラント・テクノロジーズ・ゲーエムベーハー Expandable and angle adjustable intervertebral cage with range of motion joints
US10888433B2 (en) 2016-12-14 2021-01-12 DePuy Synthes Products, Inc. Intervertebral implant inserter and related methods
US9795543B1 (en) * 2017-01-06 2017-10-24 Pac-dent International Inc. Nano-complexes for enamel remineralization
US10398563B2 (en) 2017-05-08 2019-09-03 Medos International Sarl Expandable cage
US11344424B2 (en) 2017-06-14 2022-05-31 Medos International Sarl Expandable intervertebral implant and related methods
US10940016B2 (en) 2017-07-05 2021-03-09 Medos International Sarl Expandable intervertebral fusion cage
JP2020533070A (en) 2017-09-08 2020-11-19 パイオニア サージカル テクノロジー インコーポレイテッド Intervertebral implants, instruments, and methods
USD907771S1 (en) 2017-10-09 2021-01-12 Pioneer Surgical Technology, Inc. Intervertebral implant
US11235086B2 (en) 2018-02-22 2022-02-01 Cerapedics, Inc. Processes for coating inorganic particles with a peptide or protein useful for improving cellular activity related to bone growth
US11446156B2 (en) 2018-10-25 2022-09-20 Medos International Sarl Expandable intervertebral implant, inserter instrument, and related methods
CN109534310B (en) * 2019-01-31 2022-01-25 中化云龙有限公司 Dechromization method for feed monocalcium phosphate
US11426286B2 (en) 2020-03-06 2022-08-30 Eit Emerging Implant Technologies Gmbh Expandable intervertebral implant
US11850160B2 (en) 2021-03-26 2023-12-26 Medos International Sarl Expandable lordotic intervertebral fusion cage
US11752009B2 (en) 2021-04-06 2023-09-12 Medos International Sarl Expandable intervertebral fusion cage
CN115382016B (en) * 2021-05-19 2023-06-23 北京荷月顺畅生物科技有限公司 Bionic bone material for resisting cancer, medicinal composition containing bionic bone material and preparation method of medicinal composition
CN115382010B (en) * 2021-05-19 2023-06-06 北京荷月顺畅生物科技有限公司 Bionic bone material and preparation method thereof

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4157378A (en) 1973-01-11 1979-06-05 Colgate Palmolive Company Process for preparing fluorapatite
JPS5654841A (en) 1979-10-08 1981-05-15 Mitsubishi Mining & Cement Co Bone broken portion and filler for void portion and method of treating bone of animal using said filler
USRE33161E (en) * 1982-04-29 1990-02-06 American Dental Association Health Foundation Combinations of sparingly soluble calcium phosphates in slurries and pastes as mineralizers and cements
USRE33221E (en) * 1982-04-29 1990-05-22 American Dental Association Health Foundation Dental restorative cement pastes
US4518430A (en) * 1982-04-29 1985-05-21 American Dental Association Health Foundation Dental resptorative cement pastes
US5286763A (en) 1983-03-22 1994-02-15 Massachusetts Institute Of Technology Bioerodible polymers for drug delivery in bone
US4612053A (en) * 1983-10-06 1986-09-16 American Dental Association Health Foundation Combinations of sparingly soluble calcium phosphates in slurries and pastes as mineralizers and cements
JPS6117409A (en) 1984-07-02 1986-01-25 Meishin Toryo Kk Preparation of amorphous calcium phosphate and bio-compatible composition composed mainly thereof
DE3433210C1 (en) * 1984-09-10 1986-06-05 Hans Dr.med. Dr.med.dent. 8000 München Scheicher Means for filling bone and tooth defects, for bone building, for bone contact layers and for bone and tooth root replacement and use of carbonate apatite for this purpose
JPS62182146A (en) * 1985-10-11 1987-08-10 三井東圧化学株式会社 Hardenable material
JPS62260707A (en) * 1986-04-16 1987-11-13 Ebara Infilco Co Ltd Production of high purity hydroxyapatite
JPH0720486B2 (en) 1986-10-30 1995-03-08 京セラ株式会社 Calcium phosphate-based bioprosthetic material and method for producing the same
US4778471A (en) 1986-11-19 1988-10-18 University Of Dayton Zcap ceramics
US4737411A (en) * 1986-11-25 1988-04-12 University Of Dayton Controlled pore size ceramics particularly for orthopaedic and dental applications
JPS63170205A (en) * 1987-01-09 1988-07-14 Jgc Corp Production of hydroxyapatite
US5085861A (en) 1987-03-12 1992-02-04 The Beth Israel Hospital Association Bioerodable implant composition comprising crosslinked biodegradable polyesters
DE3709897A1 (en) * 1987-03-26 1988-10-06 Ewers Rolf METHOD OF MANUFACTURING A HYDROXYLAPATITE MATERIAL
US5962028A (en) 1988-04-20 1999-10-05 Norian Corporation Carbonated hydroxyapatite compositions and uses
US5129905A (en) * 1988-04-20 1992-07-14 Norian Corporation Methods for in situ prepared calcium phosphate minerals
US5053212A (en) * 1988-04-20 1991-10-01 Norian Corporation Intimate mixture of calcium and phosphate sources as precursor to hydroxyapatite
US5047031A (en) * 1988-04-20 1991-09-10 Norian Corporation In situ calcium phosphate minerals method
US4880610A (en) * 1988-04-20 1989-11-14 Norian Corporation In situ calcium phosphate minerals--method and composition
US5178845A (en) * 1988-04-20 1993-01-12 Norian Corporation Intimate mixture of calcium and phosphate sources as precursor to hydroxyapatite
US4849193A (en) * 1988-05-02 1989-07-18 United States Gypsum Company Process of preparing hydroxylapatite
JPH02182261A (en) 1989-01-06 1990-07-16 Olympus Optical Co Ltd Preparation of ceramic member for living body
US5034059A (en) 1989-02-17 1991-07-23 Norian Corporation Composition comprising octacalcium phosphate crystals and polypeptide
US5460803A (en) * 1989-05-24 1995-10-24 American Dental Association Health Foundation Methods and compositions for mineralizing and fluoridating calcified tissues
US5037639A (en) * 1989-05-24 1991-08-06 American Dental Association Health Foundation Methods and compositions for mineralizing calcified tissues
US5164187A (en) * 1990-04-05 1992-11-17 Norian Corporation Hydroxyapatite prosthesis coatings
NL9001544A (en) 1990-07-06 1992-02-03 Stamicarbon COMPOSITION CONTAINING HYDROXYL AMINES AND POLYISOCYANATES.
EP0541687B1 (en) 1990-07-27 1997-08-27 Norian Corporation Intimate mixture of calcium and phosphate sources as precursor to hydroxyapatite
JP2621622B2 (en) 1990-09-27 1997-06-18 三菱マテリアル株式会社 Hydraulic calcium phosphate cement
US5149368A (en) * 1991-01-10 1992-09-22 Liu Sung Tsuen Resorbable bioactive calcium phosphate cement
US5262166A (en) 1991-04-17 1993-11-16 Lty Medical Inc Resorbable bioactive phosphate containing cements
US5782971B1 (en) 1991-06-28 1999-09-21 Norian Corp Calcium phosphate cements comprising amorophous calcium phosphate
JP2686684B2 (en) 1991-08-27 1997-12-08 寅雄 大塚 Tube mesh knitted with hydroxyapatite and knitted with biosoluble fibers
US5605713A (en) 1991-11-22 1997-02-25 Boltong; Maria G. Process for the preparation of calcium phosphate cements and its application as bio-materials
US5281265A (en) 1992-02-03 1994-01-25 Liu Sung Tsuen Resorbable surgical cements
JPH05305134A (en) 1992-04-30 1993-11-19 Japan Steel Works Ltd:The Porous calcium phosphate material for bone formation
GB9215356D0 (en) * 1992-07-20 1992-09-02 Univ Reading The Bone materials
JP3310291B2 (en) 1992-08-13 2002-08-05 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア Bioactive substance template for in vitro synthesis of bone tissue
JP3170059B2 (en) 1992-08-25 2001-05-28 誠 大塚 Calcium phosphate drug sustained-release body and method for producing the same
JPH07277712A (en) 1992-12-18 1995-10-24 Hokkaido Sogo Gijutsu Kenkyusho:Kk Production of natural hydroxyapatite by fluidized bed baking method
JPH0798650B2 (en) 1993-01-11 1995-10-25 工業技術院長 Method for producing plate-shaped hydroxyapatite
US5522893A (en) * 1993-03-12 1996-06-04 American Dental Association Health Foundation Calcium phosphate hydroxyapatite precursor and methods for making and using the same
US5565502A (en) 1993-03-24 1996-10-15 Children's Medical Center Corporation Isolation of the calcium-phosphate crystals of bone
US5709854A (en) 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
GB9310321D0 (en) * 1993-05-19 1993-06-30 Queen Mary & Westfield College Method for the preparation of carbonated hydroxyapatite compositions
RU2077329C1 (en) 1993-07-21 1997-04-20 Акционерное общество закрытого типа "ОСТИМ" Agent for osseous tissue growth stimulation
US5525148A (en) * 1993-09-24 1996-06-11 American Dental Association Health Foundation Self-setting calcium phosphate cements and methods for preparing and using them
US5516532A (en) 1994-08-05 1996-05-14 Children's Medical Center Corporation Injectable non-immunogenic cartilage and bone preparation
US5496399A (en) * 1994-08-23 1996-03-05 Norian Corporation Storage stable calcium phosphate cements
US5676976A (en) 1995-05-19 1997-10-14 Etex Corporation Synthesis of reactive amorphous calcium phosphates
US5700289A (en) 1995-10-20 1997-12-23 North Shore University Hospital Research Corporation Tissue-engineered bone repair using cultured periosteal cells
US5783217A (en) * 1995-11-07 1998-07-21 Etex Corporation Low temperature calcium phosphate apatite and a method of its manufacture

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