CA2220997A1 - Adenovirus vectors for gene therapy - Google Patents

Adenovirus vectors for gene therapy

Info

Publication number
CA2220997A1
CA2220997A1 CA002220997A CA2220997A CA2220997A1 CA 2220997 A1 CA2220997 A1 CA 2220997A1 CA 002220997 A CA002220997 A CA 002220997A CA 2220997 A CA2220997 A CA 2220997A CA 2220997 A1 CA2220997 A1 CA 2220997A1
Authority
CA
Canada
Prior art keywords
gene therapy
adenovirus vectors
useful
contain
provides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002220997A
Other languages
French (fr)
Other versions
CA2220997C (en
Inventor
Frank L. Graham
Martina Anton
Michael A. Rudnicki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Advec Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2220997A1 publication Critical patent/CA2220997A1/en
Application granted granted Critical
Publication of CA2220997C publication Critical patent/CA2220997C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

Abstract

This invention provides a method for making adenovirus cloning vectors which contain a recombinase target site that is useful for the insertion of selected foreign proteins.
CA002220997A 1995-06-07 1996-06-07 Adenovirus vectors for gene therapy Expired - Lifetime CA2220997C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/473,168 US5919676A (en) 1993-06-24 1995-06-07 Adenoviral vector system comprising Cre-loxP recombination
US08/473,168 1995-06-07
PCT/CA1996/000375 WO1996040955A1 (en) 1995-06-07 1996-06-07 Adenovirus vectors for gene therapy

Publications (2)

Publication Number Publication Date
CA2220997A1 true CA2220997A1 (en) 1996-12-19
CA2220997C CA2220997C (en) 2007-04-24

Family

ID=23878471

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002220997A Expired - Lifetime CA2220997C (en) 1995-06-07 1996-06-07 Adenovirus vectors for gene therapy

Country Status (8)

Country Link
US (2) US5919676A (en)
EP (1) EP0832267B1 (en)
JP (1) JP3492700B2 (en)
AT (1) ATE213022T1 (en)
AU (1) AU724161B2 (en)
CA (1) CA2220997C (en)
DE (1) DE69619110T2 (en)
WO (1) WO1996040955A1 (en)

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Also Published As

Publication number Publication date
JP3492700B2 (en) 2004-02-03
JPH11506334A (en) 1999-06-08
EP0832267A1 (en) 1998-04-01
ATE213022T1 (en) 2002-02-15
WO1996040955A1 (en) 1996-12-19
DE69619110D1 (en) 2002-03-21
AU5889796A (en) 1996-12-30
US20010041173A1 (en) 2001-11-15
EP0832267B1 (en) 2002-02-06
DE69619110T2 (en) 2002-07-18
CA2220997C (en) 2007-04-24
US5919676A (en) 1999-07-06
AU724161B2 (en) 2000-09-14

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