CA2228137A1 - Apparatus and methods for improved noninvasive dermal administration of pharmaceuticals - Google Patents

Apparatus and methods for improved noninvasive dermal administration of pharmaceuticals

Info

Publication number
CA2228137A1
CA2228137A1 CA002228137A CA2228137A CA2228137A1 CA 2228137 A1 CA2228137 A1 CA 2228137A1 CA 002228137 A CA002228137 A CA 002228137A CA 2228137 A CA2228137 A CA 2228137A CA 2228137 A1 CA2228137 A1 CA 2228137A1
Authority
CA
Canada
Prior art keywords
heat
generating
reservoir
drug formulation
user
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002228137A
Other languages
French (fr)
Other versions
CA2228137C (en
Inventor
Jie Zhang
Hao Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nuvo Research Inc
Original Assignee
Jie Zhang
Hao Zhang
Zars, Inc.
Zars Pharma, Inc.
Nuvo Research America, Inc.
Nuvo Research Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jie Zhang, Hao Zhang, Zars, Inc., Zars Pharma, Inc., Nuvo Research America, Inc., Nuvo Research Inc. filed Critical Jie Zhang
Priority to CA002408585A priority Critical patent/CA2408585C/en
Publication of CA2228137A1 publication Critical patent/CA2228137A1/en
Application granted granted Critical
Publication of CA2228137C publication Critical patent/CA2228137C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02—Compresses or poultices for effecting heating or cooling
    • A61F7/03—Compresses or poultices for effecting heating or cooling thermophore, i.e. self-heating, e.g. using a chemical reaction
    • A61F7/032—Compresses or poultices for effecting heating or cooling thermophore, i.e. self-heating, e.g. using a chemical reaction using oxygen from the air, e.g. pocket-stoves
    • A61F7/034—Flameless
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02—Compresses or poultices for effecting heating or cooling
    • A61F2007/0261—Compresses or poultices for effecting heating or cooling medicated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00089—Wound bandages
    • A61F2013/00187—Wound bandages insulating; warmth or cold applying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00089—Wound bandages
    • A61F2013/00187—Wound bandages insulating; warmth or cold applying
    • A61F2013/00204—Wound bandages insulating; warmth or cold applying insulating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00902—Plasters containing means
    • A61F2013/00906—Plasters containing means for transcutaneous or transdermal drugs application
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00902—Plasters containing means
    • A61F2013/0091—Plasters containing means with disinfecting or anaesthetics means, e.g. anti-mycrobic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

Abstract

An apparatus, product formulation, and method for improved dermal permeation of pharmaceuticals wherein the apparatus includes a thin drug formulation reservoir and a heat-generating chamber separated by a first non-permeable wall, wherein the reservoir and chamber are formed in or supported by a housing. The drug formulation reservoir houses or is capable of housing a predetermined amount of a formulation containing pharmaceutically-active agent(s). The heat-generating/temperature-regulating chamber includes a medium for generating controlled heat, preferably a chemical composition made of carbon, iron, water and/or salt which is activated upon contact with air (oxygen). The function of the heat-generating/temperature-regulating element is to heat the user's skin, rapidly bring the skin temperature to a desired and elevated narrow range and keep it in this range for sufficient time to obtain more rapid, enhanced and less variable dermal absorption of selected pharmaceutically-active agents and to obtain improved clinical effets. Structure for controlling the generation of heat is also disclosed. The apparatus may optionally include a spacing or standoff structure which spans the drug formulation reservoir between the non-permeable wall and the user's skin surface for maintaining a predetermined thickness of the drug formulation on the user's skin surface. Also, a novel product formulation which can be used with the apparatus which uses high percentage of eutectic mixture of local anesthetics to reduce the overall degradation rate of the local anesthetic compound(s) in formulations which are subject to hydrolysis.
CA002228137A 1995-07-28 1996-07-26 Apparatus and methods for improved noninvasive dermal administration of pharmaceuticals Expired - Fee Related CA2228137C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002408585A CA2408585C (en) 1995-07-28 1996-07-26 Apparatus and methods for improved noninvasive dermal administration of pharmaceuticals

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US508,463 1995-07-28
US08/508,463 US5658583A (en) 1995-07-28 1995-07-28 Apparatus and methods for improved noninvasive dermal administration of pharmaceuticals
PCT/US1996/012319 WO1997004728A1 (en) 1995-07-28 1996-07-26 Apparatus and methods for improved noninvasive dermal administration of pharmaceuticals

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002408585A Division CA2408585C (en) 1995-07-28 1996-07-26 Apparatus and methods for improved noninvasive dermal administration of pharmaceuticals

Publications (2)

Publication Number Publication Date
CA2228137A1 true CA2228137A1 (en) 1997-02-13
CA2228137C CA2228137C (en) 2005-01-25

Family

ID=24022872

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002228137A Expired - Fee Related CA2228137C (en) 1995-07-28 1996-07-26 Apparatus and methods for improved noninvasive dermal administration of pharmaceuticals
CA002408585A Expired - Lifetime CA2408585C (en) 1995-07-28 1996-07-26 Apparatus and methods for improved noninvasive dermal administration of pharmaceuticals

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA002408585A Expired - Lifetime CA2408585C (en) 1995-07-28 1996-07-26 Apparatus and methods for improved noninvasive dermal administration of pharmaceuticals

Country Status (10)

Country Link
US (2) US5658583A (en)
EP (2) EP2279713A3 (en)
JP (1) JP3547453B2 (en)
CN (2) CN100515418C (en)
AT (1) ATE489949T1 (en)
AU (1) AU6638696A (en)
CA (2) CA2228137C (en)
DE (1) DE69638298D1 (en)
ES (1) ES2357378T3 (en)
WO (1) WO1997004728A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9012477B2 (en) 2009-01-06 2015-04-21 Nuvo Research Inc. Method of treating neuropathic pain
US9186334B2 (en) 2009-05-04 2015-11-17 Nuvo Research Inc. Heat assisted lidocaine and tetracaine for transdermal analgesia
US9186273B2 (en) 2009-05-04 2015-11-17 Nuvo Research Inc. Methods of treating pains associated with neuroma, nerve entrapment, and other conditions

Families Citing this family (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7537605B2 (en) * 1993-10-04 2009-05-26 Huan-Chen Li Medical device for treating skin itch and rash
US6284266B1 (en) * 1995-07-28 2001-09-04 Zars, Inc. Methods and apparatus for improved administration of fentanyl and sufentanil
US20020114827A1 (en) * 1995-07-28 2002-08-22 Jie Zhang Methods and apparatus for improved administration of analgesics
US6245347B1 (en) * 1995-07-28 2001-06-12 Zars, Inc. Methods and apparatus for improved administration of pharmaceutically active compounds
US6756053B2 (en) * 1995-07-28 2004-06-29 Zars, Inc. Controlled heat induced rapid delivery of pharmaceuticals from skin depot
US20040265353A1 (en) * 1995-07-28 2004-12-30 Zars, Inc. Systems and methods for treating panic attacks
CA2289966A1 (en) * 1997-05-14 1998-11-19 Galen (Chemicals) Limited Topical compositions
ATE348601T1 (en) 1998-05-18 2007-01-15 Takeda Pharmaceutical ORACULATE TABLET CONTAINING A BENZIMIDAZOLE
ES2347968T3 (en) 1998-07-28 2010-11-26 Takeda Pharmaceutical Company Limited SOLID PREPARATION THAT DISAPPEARS RAPIDLY.
US6726673B1 (en) * 1999-05-24 2004-04-27 Zars, Inc. Methods and apparatus for improved administration of testosterone pharmaceuticals
US6955819B2 (en) 1998-09-29 2005-10-18 Zars, Inc. Methods and apparatus for using controlled heat to regulate transdermal and controlled release delivery of fentanyl, other analgesics, and other medical substances
WO2000018339A1 (en) * 1998-09-29 2000-04-06 Zars, Inc. Methods and apparatus for improved administration of pharmaceutically active compounds
CN1899644B (en) * 1998-09-29 2012-12-12 沙斯公司 Methods and apparatus for improved administration of pharmaceutically active compounds
US20040073258A1 (en) * 1999-01-06 2004-04-15 Church W. Edward Body tissue and skin treatment method using pulsing heating pad and topical cream
US6572871B1 (en) * 1999-01-06 2003-06-03 W. Edward Church Pain treatment method and apparatus using heating wrap and analgesic cream
ATE290902T1 (en) 1999-04-16 2005-04-15 Johnson & Johnson Consumer DEVICE FOR IONTOPHORETIC ADMINISTRATION OF MEDICATION WITH INTERNAL SENSORS
US6453648B1 (en) 1999-07-06 2002-09-24 Zars, Inc. Method for manufacturing a heat generating apparatus
CA2375643C (en) 1999-07-08 2009-01-27 Johnson & Johnson Consumer Companies, Inc. Exothermic topical delivery device
US6890553B1 (en) 1999-07-08 2005-05-10 Johnson & Johnson Consumer Companies, Inc. Exothermic topical delivery device
AU6076200A (en) * 1999-07-08 2001-01-30 Johnson & Johnson Consumer Companies, Inc. Exothermic bandage
US7133717B2 (en) * 1999-08-25 2006-11-07 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery and diagnostic sampling
US6528086B2 (en) * 1999-09-28 2003-03-04 Zars, Inc. Methods and apparatus for drug delivery involving phase changing formulations
US6503761B1 (en) 1999-10-19 2003-01-07 Kimberly-Clark Worldwide, Inc. Selective removal of contaminants from a surface using articles having magnets
US6841393B2 (en) 1999-10-19 2005-01-11 Kimberly-Clark Worldwide, Inc. Selective removal of contaminants from a surface using colored particles and articles having magnets
US6383511B1 (en) 1999-10-25 2002-05-07 Epicept Corporation Local prevention or amelioration of pain from surgically closed wounds
EP1280485A4 (en) * 2000-02-29 2006-11-29 Zars Inc Improved transdermal drug patch
WO2001064151A1 (en) * 2000-02-29 2001-09-07 Jie Zhang Methods and apparatus for controlled heat to regulate transdermal delivery of medical substances
US6261595B1 (en) 2000-02-29 2001-07-17 Zars, Inc. Transdermal drug patch with attached pocket for controlled heating device
US6455066B1 (en) 2000-03-10 2002-09-24 Epicept Corporation Intradermal-penetration agents for topical local anesthetic administration
US7404815B2 (en) * 2000-05-01 2008-07-29 Lifescan, Inc. Tissue ablation by shear force for sampling biological fluids and delivering active agents
US20020106407A1 (en) * 2000-12-11 2002-08-08 Dennis Coleman Method and apparatus for treating breakthrough pain
US20030022203A1 (en) * 2001-04-23 2003-01-30 Rajan Kumar Cellular Arrays
US6993394B2 (en) 2002-01-18 2006-01-31 Calfacion Corporation System method and apparatus for localized heating of tissue
US6850804B2 (en) 2002-01-18 2005-02-01 Calfacior Corporation System method and apparatus for localized heating of tissue
US7048756B2 (en) * 2002-01-18 2006-05-23 Apasara Medical Corporation System, method and apparatus for evaluating tissue temperature
US20040167039A1 (en) * 2002-05-01 2004-08-26 Nawaz Ahmad Warming and nonirritating lubricant compositions and method of comparing irritation
US7658941B2 (en) * 2002-05-01 2010-02-09 Johnson & Johnson Consumer Companies, Inc. Warming and nonirritating lubricant compositions and method of comparing irritation
US7417013B2 (en) * 2002-05-01 2008-08-26 Mcneil-Ppc, Inc. Warming and nonirritating lubricant compositions and method of comparing irritation
AU2003234311A1 (en) * 2002-05-01 2003-11-17 Selig Sealing Products, Inc. Warming and nonirritating lubricant antifungal gel compositions
US7005408B2 (en) * 2002-05-01 2006-02-28 Mcneil-Ppc, Inc. Warming and nonirritating lubricant compositions and method of comparing irritation
US7695730B2 (en) * 2002-05-01 2010-04-13 Mcneil-Ppc, Inc. Warming and nonirritating lubricant compositions and method of comparing irritation
US20040185065A1 (en) * 2002-05-01 2004-09-23 Nawaz Ahmad Warming and nonirritating lubricant compositions and method of comparing irritation
US6893453B2 (en) * 2002-12-17 2005-05-17 Kimberly-Clark Worldwide, Inc. Thermal therapy pad with variable heat control
CA2513402A1 (en) * 2003-02-07 2004-08-19 Walter Mueller Transdermal therapeutic system suitable for heat application for promoting the permeation of active substances, and the use thereof
US20040191301A1 (en) * 2003-03-27 2004-09-30 Van Duren Albert Philip Transdermal device having a phase change material
US7137979B2 (en) * 2003-05-31 2006-11-21 Tyrell, Inc. Methods and devices for the treatment of skin lesions
US20050049662A1 (en) * 2003-08-27 2005-03-03 Kimberly-Clark Worldwide, Inc. Adjustable temperature heat patch
US20090053163A1 (en) * 2003-10-30 2009-02-26 Nawaz Ahmad Warming and nonirritating lubricant compositions and method of comparing irritation
US7041124B2 (en) 2003-12-23 2006-05-09 Kimberly-Clark Worldwide, Inc. System and method for providing therapy to a portion of a body
US20050266085A1 (en) * 2004-05-28 2005-12-01 Warner Kevin S Gelled emulsion and microemulsion formulations for dermal drug delivery
US20080019927A1 (en) * 2004-06-07 2008-01-24 Jie Zhang Compositions and methods for dermally treating neuropathy with minoxidil
US8741332B2 (en) * 2004-06-07 2014-06-03 Nuvo Research Inc. Compositions and methods for dermally treating neuropathic pain
US20070196457A1 (en) * 2004-06-07 2007-08-23 Jie Zhang Two or more volatile solvent-containing compositions and methods for dermal delivery of drugs
US8741333B2 (en) 2004-06-07 2014-06-03 Nuvo Research Inc. Compositions and methods for treating dermatitis or psoriasis
US20070196323A1 (en) * 2004-06-07 2007-08-23 Jie Zhang Polyvinyl alcohol-containing compositions and methods for dermal delivery of drugs
US20070190124A1 (en) * 2004-06-07 2007-08-16 Jie Zhang Two or more solidifying agent-containing compositions and methods for dermal delivery of drugs
US8907153B2 (en) * 2004-06-07 2014-12-09 Nuvo Research Inc. Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same
US20070196453A1 (en) * 2004-06-07 2007-08-23 Jie Zhang Two or more non-volatile solvent-containing compositions and methods for dermal delivery of drugs
US20070196293A1 (en) * 2004-06-07 2007-08-23 Jie Zhang Compositions and methods for treating photo damaged skin
US20070189978A1 (en) * 2004-06-07 2007-08-16 Jie Zhang Compositions and methods for dermally treating musculoskeletal pain
US20070196325A1 (en) * 2004-06-07 2007-08-23 Jie Zhang Compositions and methods for dermally treating infections
US20070196452A1 (en) * 2004-06-07 2007-08-23 Jie Zhang Flux-enabling compositions and methods for dermal delivery of drugs
GB0412793D0 (en) * 2004-06-09 2004-07-14 Boots Healthcare Int Ltd Therapeutic product
US20060105029A1 (en) * 2004-11-12 2006-05-18 Jie Zhang Instant patch for dermal drug delivery
CN101080220A (en) * 2004-12-17 2007-11-28 阿尔扎公司 Temperature modulation of transdermal drug delivery
DE102005002946A1 (en) * 2005-01-18 2006-07-27 Bsm - Bionic Solution Management Gmbh Herpes treatment facility
WO2006086513A2 (en) 2005-02-08 2006-08-17 Carewave, Inc. Apparatus and method for using a portable thermal device to reduce accommodation of nerve receptors
US7198614B2 (en) * 2005-02-11 2007-04-03 Charlie's Chemo T-Shirts, Inc. Method and apparatus for adapting clothing to allow access for medical procedures
WO2006099541A2 (en) * 2005-03-15 2006-09-21 Richard Daniel Carliss Therapeutic wound care product
US20070059250A1 (en) * 2005-09-12 2007-03-15 Nawaz Ahmad Sprayable personal lubricant
US7851419B2 (en) 2005-09-12 2010-12-14 Nawaz Ahmad Substantially anhydrous sprayable personal lubricant
US7878187B2 (en) * 2005-09-23 2011-02-01 Wyeth Llc Heat cells comprising exothermic compositions having absorbent gelling material
US7794649B2 (en) * 2005-09-23 2010-09-14 Wyeth Llc Method of making heat cells comprising exothermic compositions having absorbent gelling material
US8048089B2 (en) 2005-12-30 2011-11-01 Edge Systems Corporation Apparatus and methods for treating the skin
US9566088B2 (en) 2006-03-29 2017-02-14 Edge Systems Llc Devices, systems and methods for treating the skin
US20070280972A1 (en) * 2006-04-25 2007-12-06 Zars, Inc. Adhesive solid gel-forming formulations for dermal drug delivery
US9004059B2 (en) * 2006-08-10 2015-04-14 Rechargeable Battery Corporation Reusable heater in a package
US8653066B2 (en) 2006-10-09 2014-02-18 Charleston Laboratories, Inc. Pharmaceutical compositions
KR20090128499A (en) 2007-03-19 2009-12-15 인슐린 메디컬 엘티디 Drug delivery device
US9220837B2 (en) 2007-03-19 2015-12-29 Insuline Medical Ltd. Method and device for drug delivery
US8622991B2 (en) 2007-03-19 2014-01-07 Insuline Medical Ltd. Method and device for drug delivery
WO2009081262A1 (en) 2007-12-18 2009-07-02 Insuline Medical Ltd. Drug delivery device with sensor for closed-loop operation
KR20090127920A (en) * 2007-03-20 2009-12-14 와이어쓰 Thermal device
US20090082738A1 (en) * 2007-09-24 2009-03-26 Vad Vijay B Natural Anti-Inflammatory Agents for Reducing Pain
US20090112231A1 (en) * 2007-10-31 2009-04-30 Luizzi Joseph M Epilatory product comprising an air-activated heat-generating module
US8579953B1 (en) 2007-12-07 2013-11-12 Peter J. Dunbar Devices and methods for therapeutic heat treatment
JP5508285B2 (en) 2008-01-04 2014-05-28 エッジ システムズ コーポレーション Apparatus and method for treating skin
EP2240022B1 (en) 2008-01-09 2016-12-28 Charleston Laboratories, Inc. Bilayered tablets comprising oxycodone and promethazine
MX2010012415A (en) 2008-05-15 2011-03-29 Wyeth Llc Star Portable moist heat system.
CN102245137A (en) 2008-11-07 2011-11-16 茵苏莱恩医药有限公司 Device and method for drug delivery
JP4934163B2 (en) * 2009-03-18 2012-05-16 オカモト株式会社 Skin laminate
EP2413837A4 (en) * 2009-04-01 2013-10-23 Jie Zhang Methods for treating myofascial, muscle, and/or back pain
WO2011006012A1 (en) 2009-07-08 2011-01-13 Charleston Laboratories Inc. Pharmaceutical compositions
CN102834096A (en) 2010-01-14 2012-12-19 卢福研究公司 Solid-forming local anesthetic formulations for pain control
JP4934210B2 (en) * 2010-03-05 2012-05-16 オカモト株式会社 Skin laminate
CN102844022A (en) 2010-04-21 2012-12-26 帝国制药美国公司 Local anesthetic emulsion compositions and methods of making and using the same
CA2860977C (en) 2011-01-21 2022-01-11 Charles Chabal Modular stimulus applicator system and method
GB201116271D0 (en) * 2011-09-21 2011-11-02 Univ Cardiff Dispersion anaesthetic device
US10583037B2 (en) * 2013-01-23 2020-03-10 Transqtronics, Llc. Heating device using exothermic chemical reaction
US10010445B2 (en) 2013-01-23 2018-07-03 Jonathan Isserow Treatment device using nanotechnology
US9675817B2 (en) * 2013-01-23 2017-06-13 Jonathan Isserow Heating device using exothermic chemical reaction
US9636521B2 (en) 2013-07-12 2017-05-02 Jonathan Isserow Heat and light treatment device using nanotechnology
US10583307B2 (en) * 2013-01-23 2020-03-10 Transqtronics, Llc. Heating device and method of use
EP2967633B1 (en) 2013-03-15 2018-04-25 Edge Systems LLC Devices for treating the skin
WO2015109397A1 (en) * 2014-01-22 2015-07-30 Ekaabo Inc. Portable device for treating external boils
EP4324414A2 (en) 2014-12-23 2024-02-21 HydraFacial LLC Devices and methods for treating the skin using a rollerball or a wicking member
US10179229B2 (en) 2014-12-23 2019-01-15 Edge Systems Llc Devices and methods for treating the skin using a porous member
JP2019507181A (en) 2016-03-04 2019-03-14 チャールストン ラボラトリーズ，インコーポレイテッド Pharmaceutical composition
DE102019105694A1 (en) 2019-03-06 2020-09-10 Lts Lohmann Therapie-Systeme Ag Microneedle array having a heat-generating element
USD1016615S1 (en) 2021-09-10 2024-03-05 Hydrafacial Llc Container for a skin treatment device

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3929131A (en) * 1975-01-09 1975-12-30 Thomas L Hardwick Bandage and method of using same
SE7713618L (en) * 1977-12-01 1979-06-02 Astra Laekemedel Ab LOCAL ANESTHETIC MIXTURE
US4230105A (en) * 1978-11-13 1980-10-28 Merck & Co., Inc. Transdermal delivery of drugs
US4286592A (en) * 1980-02-04 1981-09-01 Alza Corporation Therapeutic system for administering drugs to the skin
JPS60174716A (en) * 1984-02-21 1985-09-09 Yamanouchi Pharmaceut Co Ltd Medicinal patch
GB2163956B (en) * 1984-09-08 1988-03-30 Ile De France Percutaneous anaesthetic composition for topical application
US4747841A (en) * 1985-03-19 1988-05-31 Yasuro Kuratomi Methods and instruments of moxibustion
US4693706A (en) * 1986-08-11 1987-09-15 Mark L. Anderson Two compartment mixing syringe
DE3762480D1 (en) * 1986-08-23 1990-06-07 Arno W Latzke AGENT FOR APPLICATION OF TRANSDERMAL RESORBABLE ACTIVE SUBSTANCES.
US4911707A (en) * 1987-02-13 1990-03-27 Ciba-Geigy Corporation Monolithic user-activated transdermal therapeutic system
GB8712518D0 (en) * 1987-05-28 1987-07-01 Univ Belfast Unit-dose film composition
CN87208915U (en) * 1987-06-06 1988-02-03 长春市明胶厂 Bosom oven for medicinal physiotherapy
DK158336C (en) * 1987-09-22 1990-10-01 Coloplast As CONNECTOR MATERIALS FOR THE TREATMENT OF WOUNDS AND TEMPLES FOR USE IN MANUFACTURING THEREOF
US4830855A (en) * 1987-11-13 1989-05-16 Landec Labs, Inc. Temperature-controlled active agent dispenser
JPH01122037U (en) * 1988-02-12 1989-08-18
DE3806562A1 (en) * 1988-03-01 1989-09-14 Alpha Therapeutic Gmbh TWO CHAMBER SYRINGE WITH A FILLING OF ACTIVITY SENSITIVE HUMAN PROTEIN AS AN ACTIVE SUBSTANCE
US4913957A (en) * 1988-05-23 1990-04-03 Kimberly-Clark Corporation Thermal retaining fabric laminate
US5378730A (en) * 1988-06-09 1995-01-03 Alza Corporation Permeation enhancer comprising ethanol and monoglycerides
DE3903794A1 (en) * 1989-02-09 1990-08-16 Lohmann Therapie Syst Lts THERAPEUTIC SYSTEM FOR THE TRANSDERMAL OR TRANSMUCOSAL ADMINISTRATION OF ACTIVE SUBSTANCES AND ITS USE
US5217718A (en) * 1989-08-18 1993-06-08 Cygnus Therapeutic Systems Method and device for administering dexmedetomidine transdermally
US5276032A (en) * 1989-12-28 1994-01-04 King O Newton Vision aid and anesthetic composition
US5229133A (en) * 1990-01-24 1993-07-20 Alza Corporation Delivery system comprising means for controlling internal pressure
US5279594A (en) * 1990-05-23 1994-01-18 Jackson Richard R Intubation devices with local anesthetic effect for medical use
US5114411A (en) * 1990-11-19 1992-05-19 Habley Medical Technology Corporation Multi-chamber vial
US5108710A (en) * 1990-11-26 1992-04-28 Little Amy C Transdermal patch holder
US5213129A (en) * 1991-03-25 1993-05-25 Csb Limited Partnership Fluid mixing device
US5329976A (en) * 1991-12-09 1994-07-19 Habley Medical Technology Corporation Syringe-filling and medication mixing dispenser
US5330452A (en) * 1993-06-01 1994-07-19 Zook Gerald P Topical medicating device

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9012477B2 (en) 2009-01-06 2015-04-21 Nuvo Research Inc. Method of treating neuropathic pain
US9186334B2 (en) 2009-05-04 2015-11-17 Nuvo Research Inc. Heat assisted lidocaine and tetracaine for transdermal analgesia
US9186273B2 (en) 2009-05-04 2015-11-17 Nuvo Research Inc. Methods of treating pains associated with neuroma, nerve entrapment, and other conditions

Also Published As

Publication number Publication date
ES2357378T8 (en) 2012-06-22
CN100515418C (en) 2009-07-22
WO1997004728A1 (en) 1997-02-13
EP2279713A2 (en) 2011-02-02
CA2228137C (en) 2005-01-25
CN1589779A (en) 2005-03-09
EP0857047A4 (en) 2005-12-28
EP0857047A1 (en) 1998-08-12
ATE489949T1 (en) 2010-12-15
JPH11510075A (en) 1999-09-07
CN1200017A (en) 1998-11-25
US5658583A (en) 1997-08-19
CA2408585C (en) 2004-02-17
JP3547453B2 (en) 2004-07-28
EP2279713A3 (en) 2011-03-30
ES2357378T3 (en) 2011-04-25
CA2408585A1 (en) 1997-02-13
AU6638696A (en) 1997-02-26
EP0857047B1 (en) 2010-12-01
US5919479A (en) 1999-07-06
DE69638298D1 (en) 2011-01-13
CN1161087C (en) 2004-08-11

Similar Documents

Publication Publication Date Title
CA2228137A1 (en) Apparatus and methods for improved noninvasive dermal administration of pharmaceuticals
EP1117356B1 (en) Apparatus for improved administration of fentanyl and sufentanil
EP2356958B1 (en) Heat generating device
US5120544A (en) Crosslinked hydrogel and method for making same
US20040098072A1 (en) Steam generator
JP2005501014A5 (en)
CA2386017A1 (en) Drug delivery of phase changing formulation
JP2002525172A (en) Method and apparatus for improved application of pharmaceutically active compounds
US8267906B2 (en) Transdermal delivery apparatus and method
EP1063960A1 (en) Composition for aroma delivery
JPS63310807A (en) Foamable cosmetic
JPS545038A (en) Exothermic fumigator
KR100691093B1 (en) Pack composition for dropping heat and a Mask containing the same
KR101916095B1 (en) Carbonic Acid Mask Sheet, Manufacturing Method Thereof And Carbonic Acid Powder Dispersed Solution Therefor
CN1230670A (en) Exothermic agent and warming bag and thermotherapeutic bag with the same
JPH1176348A (en) Rotary massager
JPH02189162A (en) Sublimation drug discharge system
JPH02270811A (en) Pack cosmetic
JPH0817802B2 (en) Hot moxibustion

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20160726