CA2230228A1 - Fluorescence lifetime-based imaging and spectroscopy in tissues and other random media - Google Patents

Fluorescence lifetime-based imaging and spectroscopy in tissues and other random media

Info

Publication number
CA2230228A1
CA2230228A1 CA002230228A CA2230228A CA2230228A1 CA 2230228 A1 CA2230228 A1 CA 2230228A1 CA 002230228 A CA002230228 A CA 002230228A CA 2230228 A CA2230228 A CA 2230228A CA 2230228 A1 CA2230228 A1 CA 2230228A1
Authority
CA
Canada
Prior art keywords
tissue
excitation
light
processor
spatial variation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002230228A
Other languages
French (fr)
Other versions
CA2230228C (en
Inventor
Eva M. Sevick-Muraca
Dilip Y. Paithankar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Texas A&M University System
Original Assignee
Purdue Research Foundation
Eva M. Sevick-Muraca
Dilip Y. Paithankar
The Texas A & M University System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation, Eva M. Sevick-Muraca, Dilip Y. Paithankar, The Texas A & M University System filed Critical Purdue Research Foundation
Publication of CA2230228A1 publication Critical patent/CA2230228A1/en
Application granted granted Critical
Publication of CA2230228C publication Critical patent/CA2230228C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G01J3/4406—Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging

Abstract

A system and method non-invasive biomedical optical imaging and spectroscopy with low-level light is described. The technique consists of a modulated light source (120) coupled to tissue (100) of a patient to introduce excitation light. Fluorescent light emitted in response to the excitation light is detected with sensor (148). The AC intensity and phase of the excitation and detected fluorescent light is provided to a processor (160) operatively coupled to sensor (148). Processor (160) employs the measured re-emission kinetics of excitation and fluorescent light to "map"
the spatial variation of one or more fluorescence characteristics of the tissue (100). The fluorescence characteristic may be provided by exogenous contract agents, endogenous fluorophores, or both.
The variations is determined by solving frequency domain diffusion equations at a number of designated points in the tissue as part of a recursive estimation algorithm. Processor (160) generates an imaging signal in accordance with the spatial variation of the fluorescence characteristic for provision to an output device (164).
The output device (164) displays an image corresponding spatial variation of the fluorescence characteristic which corresponds to tissue (100) to aid in the detection and diagnosis of disease.
CA002230228A 1995-08-24 1996-08-23 Fluorescence lifetime-based imaging and spectroscopy in tissues and other random media Expired - Lifetime CA2230228C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US274695P 1995-08-24 1995-08-24
US60/002,746 1995-08-24
PCT/US1996/013658 WO1997008538A1 (en) 1995-08-24 1996-08-23 Fluorescence lifetime-based imaging and spectroscopy in tissues and other random media

Publications (2)

Publication Number Publication Date
CA2230228A1 true CA2230228A1 (en) 1997-03-06
CA2230228C CA2230228C (en) 2006-11-14

Family

ID=21702295

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002230228A Expired - Lifetime CA2230228C (en) 1995-08-24 1996-08-23 Fluorescence lifetime-based imaging and spectroscopy in tissues and other random media

Country Status (9)

Country Link
US (1) US5865754A (en)
EP (1) EP0846262A4 (en)
JP (1) JP3819032B2 (en)
CN (1) CN1200174A (en)
AU (1) AU1130797A (en)
CA (1) CA2230228C (en)
MX (1) MX9801351A (en)
NO (1) NO980750L (en)
WO (1) WO1997008538A1 (en)

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