CA2232635A1 - Intravaginal rings with insertable drug-containing core - Google Patents

Intravaginal rings with insertable drug-containing core

Info

Publication number
CA2232635A1
CA2232635A1 CA002232635A CA2232635A CA2232635A1 CA 2232635 A1 CA2232635 A1 CA 2232635A1 CA 002232635 A CA002232635 A CA 002232635A CA 2232635 A CA2232635 A CA 2232635A CA 2232635 A1 CA2232635 A1 CA 2232635A1
Authority
CA
Canada
Prior art keywords
drug
vaginal
core
channel
rings
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002232635A
Other languages
French (fr)
Other versions
CA2232635C (en
Inventor
Saleh Ismail Saleh
Harold Nash
C. Wayne Bardin
Troy Harmon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Population Council Inc
Original Assignee
The Population Council, Inc.
Saleh Ismail Saleh
Harold Nash
C. Wayne Bardin
Troy Harmon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Population Council, Inc., Saleh Ismail Saleh, Harold Nash, C. Wayne Bardin, Troy Harmon filed Critical The Population Council, Inc.
Publication of CA2232635A1 publication Critical patent/CA2232635A1/en
Application granted granted Critical
Publication of CA2232635C publication Critical patent/CA2232635C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
    • A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
    • A61F6/08—Pessaries, i.e. devices worn in the vagina to support the uterus, remedy a malposition or prevent conception, e.g. combined with devices protecting against contagion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms

Abstract

Disclosed is a vaginal ring containing a ring body made of a first polymeric material having at least one hollow internal channel defining an opening to the exterior of said body and which channel is adapted to receive a drug-containing core through said opening, and a core containing at least one intravaginally administrable drug dispersed in a second polymeric material disposed in the channel. The core is positioned in the vaginal ring body suitably prior to use in order to substantially avoid initial bursts of drug into the tissues of the subject and resultant side effects such as nausea and vomiting. Representative drugs include contraceptive agents and other steroidal substances for use in hormone replacement therapy. Also disclosed are methods for preparing the vaginal rings, kits for assembling the vaginal rings, and methods of using the vaginal rings to achieve intravaginal delivery of drugs to a female.
CA002232635A 1996-07-31 1997-07-22 Intravaginal rings with insertable drug-containing core Expired - Lifetime CA2232635C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US2379296P 1996-07-31 1996-07-31
US60/023,792 1996-07-31
US08/850,327 US5972372A (en) 1996-07-31 1997-05-02 Intravaginal rings with insertable drug-containing core
US08/850,327 1997-05-02
PCT/US1997/012777 WO1998004220A1 (en) 1996-07-31 1997-07-22 Intravaginal rings with insertable drug-containing core

Publications (2)

Publication Number Publication Date
CA2232635A1 true CA2232635A1 (en) 1998-02-05
CA2232635C CA2232635C (en) 2002-09-17

Family

ID=26697614

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002232635A Expired - Lifetime CA2232635C (en) 1996-07-31 1997-07-22 Intravaginal rings with insertable drug-containing core

Country Status (13)

Country Link
US (2) US5972372A (en)
EP (1) EP0862396B1 (en)
JP (1) JP3970936B2 (en)
CN (1) CN1154455C (en)
AT (1) ATE290836T1 (en)
AU (1) AU4043197A (en)
BR (1) BR9706802A (en)
CA (1) CA2232635C (en)
DE (1) DE69732760T2 (en)
DK (1) DK0862396T3 (en)
ES (1) ES2239363T3 (en)
PT (1) PT862396E (en)
WO (1) WO1998004220A1 (en)

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Also Published As

Publication number Publication date
BR9706802A (en) 1999-08-31
WO1998004220A1 (en) 1998-02-05
EP0862396A4 (en) 2000-09-06
EP0862396B1 (en) 2005-03-16
CN1154455C (en) 2004-06-23
DE69732760D1 (en) 2005-04-21
ES2239363T3 (en) 2005-09-16
DK0862396T3 (en) 2005-07-11
MX9802349A (en) 1998-08-30
PT862396E (en) 2005-07-29
AU4043197A (en) 1998-02-20
US6126958A (en) 2000-10-03
CA2232635C (en) 2002-09-17
JPH11512965A (en) 1999-11-09
US5972372A (en) 1999-10-26
ATE290836T1 (en) 2005-04-15
DE69732760T2 (en) 2006-04-13
JP3970936B2 (en) 2007-09-05
CN1198091A (en) 1998-11-04
EP0862396A1 (en) 1998-09-09

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Effective date: 20170724