CA2234233A1 - Retrievable bioartificial implants - Google Patents
Retrievable bioartificial implantsInfo
- Publication number
- CA2234233A1 CA2234233A1 CA002234233A CA2234233A CA2234233A1 CA 2234233 A1 CA2234233 A1 CA 2234233A1 CA 002234233 A CA002234233 A CA 002234233A CA 2234233 A CA2234233 A CA 2234233A CA 2234233 A1 CA2234233 A1 CA 2234233A1
- Authority
- CA
- Canada
- Prior art keywords
- bioartificial
- implants
- retrievable
- thin sheets
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/022—Artificial gland structures using bioreactors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Transplantation (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Cell Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Steroid Compounds (AREA)
Abstract
Bioartificial implant and methods for their manufacture and use are described, particularly bioartificial pancreases. In particular, the implants may be thin sheets which enclose cells, may be completely biocompatible over extended periods of time and may not induce fibrosis. The high-density-cell-containing thin sheets are preferably completely retrievable, and have dimensions allowing maintenance of optimal tissue viability through rapid diffusion of nutrients and oxygen and also allowing rapid changes in the secretion rate of insulin and/or other bioactive agents in response to changing physiology.
Implantations of living cells, tissue, drugs, medicines and/or enzymes, contained in the bioartificial implants may be made to treat and/or prevent disease.
Implantations of living cells, tissue, drugs, medicines and/or enzymes, contained in the bioartificial implants may be made to treat and/or prevent disease.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/542,506 US5855613A (en) | 1995-10-13 | 1995-10-13 | Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change |
US08/542506 | 1995-10-13 | ||
PCT/US1996/016499 WO1997013474A1 (en) | 1995-10-13 | 1996-10-15 | Retrievable bioartificial implants |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2234233A1 true CA2234233A1 (en) | 1997-04-17 |
CA2234233C CA2234233C (en) | 2007-01-16 |
Family
ID=24164114
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002234233A Expired - Fee Related CA2234233C (en) | 1995-10-13 | 1996-10-15 | Retrievable bioartificial implants |
Country Status (7)
Country | Link |
---|---|
US (3) | US5855613A (en) |
EP (1) | EP0862391B1 (en) |
AT (1) | ATE297169T1 (en) |
AU (1) | AU725104B2 (en) |
CA (1) | CA2234233C (en) |
DE (1) | DE69634828T2 (en) |
WO (1) | WO1997013474A1 (en) |
Families Citing this family (162)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7018419B2 (en) * | 1994-05-20 | 2006-03-28 | Spielberg Theodore E | Microporous encapsulated endocrine cell disks, biconcave disks and multidimpled chambers for hormonal replacement |
US5855613A (en) * | 1995-10-13 | 1999-01-05 | Islet Sheet Medical, Inc. | Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change |
US6001067A (en) | 1997-03-04 | 1999-12-14 | Shults; Mark C. | Device and method for determining analyte levels |
US7192450B2 (en) | 2003-05-21 | 2007-03-20 | Dexcom, Inc. | Porous membranes for use with implantable devices |
US7657297B2 (en) * | 2004-05-03 | 2010-02-02 | Dexcom, Inc. | Implantable analyte sensor |
US20050033132A1 (en) | 1997-03-04 | 2005-02-10 | Shults Mark C. | Analyte measuring device |
US6872387B1 (en) | 1998-02-24 | 2005-03-29 | The Regents Of The University Of Michigan | Three-dimensional hydrogel/cell system |
DE60018571T8 (en) * | 1999-07-28 | 2006-04-27 | Davol Inc. | HERNIENPROTHESE |
US6264695B1 (en) * | 1999-09-30 | 2001-07-24 | Replication Medical, Inc. | Spinal nucleus implant |
US20020151055A1 (en) * | 1999-11-02 | 2002-10-17 | Stegemann Jan Philip | Novel artificial pancreas |
IL134009A (en) | 2000-01-12 | 2011-07-31 | Bo2 Technologies Ltd | Implantable device |
US8012500B2 (en) * | 2000-01-01 | 2011-09-06 | Beta-O2 Technologies Ltd. | Implantable device |
WO2008065660A2 (en) * | 2006-11-28 | 2008-06-05 | Beta O2 Technologies Ltd. | Oxygen supply for cell transplant and vascularization |
US6468301B1 (en) | 2000-03-27 | 2002-10-22 | Aga Medical Corporation | Repositionable and recapturable vascular stent/graft |
US6638312B2 (en) | 2000-08-04 | 2003-10-28 | Depuy Orthopaedics, Inc. | Reinforced small intestinal submucosa (SIS) |
US8366787B2 (en) * | 2000-08-04 | 2013-02-05 | Depuy Products, Inc. | Hybrid biologic-synthetic bioabsorbable scaffolds |
US7404819B1 (en) | 2000-09-14 | 2008-07-29 | C.R. Bard, Inc. | Implantable prosthesis |
AU9118201A (en) | 2000-09-20 | 2002-04-02 | Islet Sheet Medical Llc | Improved methods for fabrication of thin sheet bio-artificial organs |
JP4197158B2 (en) | 2001-07-16 | 2008-12-17 | デピュイ・プロダクツ・インコーポレイテッド | Devices with naturally occurring biologically derived materials |
US7914808B2 (en) * | 2001-07-16 | 2011-03-29 | Depuy Products, Inc. | Hybrid biologic/synthetic porous extracellular matrix scaffolds |
WO2003007847A1 (en) * | 2001-07-16 | 2003-01-30 | Depuy Products, Inc. | Hybrid biologic-synthetic bioabsorable scaffolds |
WO2003007786A2 (en) * | 2001-07-16 | 2003-01-30 | Depuy Products, Inc. | Porous delivery scaffold and method |
AU2002316696B2 (en) | 2001-07-16 | 2007-08-30 | Depuy Products, Inc. | Cartilage repair and regeneration scaffold and method |
EP1416880B1 (en) * | 2001-07-16 | 2011-03-02 | DePuy Products, Inc. | Cartilage repair apparatus |
US7163563B2 (en) * | 2001-07-16 | 2007-01-16 | Depuy Products, Inc. | Unitary surgical device and method |
WO2003007784A2 (en) | 2001-07-16 | 2003-01-30 | Depuy Products, Inc. | Meniscus regeneration device and method |
US7819918B2 (en) * | 2001-07-16 | 2010-10-26 | Depuy Products, Inc. | Implantable tissue repair device |
US8025896B2 (en) * | 2001-07-16 | 2011-09-27 | Depuy Products, Inc. | Porous extracellular matrix scaffold and method |
US6702857B2 (en) | 2001-07-27 | 2004-03-09 | Dexcom, Inc. | Membrane for use with implantable devices |
US20030032874A1 (en) | 2001-07-27 | 2003-02-13 | Dexcom, Inc. | Sensor head for use with implantable devices |
WO2003040692A2 (en) * | 2001-11-08 | 2003-05-15 | Vanderbilt University | Method for modeling signal transduction in cells |
PT1455755E (en) * | 2001-11-20 | 2013-06-18 | Civitas Therapeutics Inc | Improved particulate compositions for pulmonary delivery |
US6790213B2 (en) | 2002-01-07 | 2004-09-14 | C.R. Bard, Inc. | Implantable prosthesis |
US8010174B2 (en) | 2003-08-22 | 2011-08-30 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
US8260393B2 (en) | 2003-07-25 | 2012-09-04 | Dexcom, Inc. | Systems and methods for replacing signal data artifacts in a glucose sensor data stream |
US7613491B2 (en) | 2002-05-22 | 2009-11-03 | Dexcom, Inc. | Silicone based membranes for use in implantable glucose sensors |
US7828728B2 (en) | 2003-07-25 | 2010-11-09 | Dexcom, Inc. | Analyte sensor |
US8364229B2 (en) | 2003-07-25 | 2013-01-29 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
US20030213007A1 (en) * | 2002-03-27 | 2003-11-13 | Slattery Charles Wilbur | Human milk produced by human mammary tissue implanted in non-human host animals and uses thereof |
US20060258761A1 (en) * | 2002-05-22 | 2006-11-16 | Robert Boock | Silicone based membranes for use in implantable glucose sensors |
US7226978B2 (en) | 2002-05-22 | 2007-06-05 | Dexcom, Inc. | Techniques to improve polyurethane membranes for implantable glucose sensors |
US20030220696A1 (en) * | 2002-05-23 | 2003-11-27 | Levine David Jerome | Implantable porous metal |
WO2004000915A2 (en) | 2002-06-24 | 2003-12-31 | Tufts University | Silk biomaterials and methods of use thereof |
US20040166169A1 (en) * | 2002-07-15 | 2004-08-26 | Prasanna Malaviya | Porous extracellular matrix scaffold and method |
US20040034275A1 (en) * | 2002-07-29 | 2004-02-19 | Peter Forsell | Multi-material incontinence treatment constriction device |
US7025982B2 (en) * | 2002-09-19 | 2006-04-11 | Medtronic, Inc. | Medical assembly suitable for long-term implantation and method for fabricating the same |
US7025791B2 (en) * | 2002-12-02 | 2006-04-11 | Gi Dynamics, Inc. | Bariatric sleeve |
WO2004075855A2 (en) * | 2003-02-26 | 2004-09-10 | Biomed Solutions, Llc | Process for in vivo treatment of specific biological targets in bodily fluid |
US7134999B2 (en) | 2003-04-04 | 2006-11-14 | Dexcom, Inc. | Optimized sensor geometry for an implantable glucose sensor |
EP3231846A1 (en) | 2003-04-10 | 2017-10-18 | Tufts University | Concentrated aqueous silk fibroin solution and use thereof |
US7875293B2 (en) | 2003-05-21 | 2011-01-25 | Dexcom, Inc. | Biointerface membranes incorporating bioactive agents |
JP4708342B2 (en) | 2003-07-25 | 2011-06-22 | デックスコム・インコーポレーテッド | Oxygen augmentation membrane system for use in implantable devices |
US20050176136A1 (en) * | 2003-11-19 | 2005-08-11 | Dexcom, Inc. | Afinity domain for analyte sensor |
WO2005012871A2 (en) * | 2003-07-25 | 2005-02-10 | Dexcom, Inc. | Increasing bias for oxygen production in an electrode system |
US9763609B2 (en) | 2003-07-25 | 2017-09-19 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
US20080119703A1 (en) | 2006-10-04 | 2008-05-22 | Mark Brister | Analyte sensor |
US20190357827A1 (en) | 2003-08-01 | 2019-11-28 | Dexcom, Inc. | Analyte sensor |
US7591801B2 (en) | 2004-02-26 | 2009-09-22 | Dexcom, Inc. | Integrated delivery device for continuous glucose sensor |
US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
US20140121989A1 (en) | 2003-08-22 | 2014-05-01 | Dexcom, Inc. | Systems and methods for processing analyte sensor data |
US7927599B2 (en) * | 2003-09-08 | 2011-04-19 | Ethicon, Inc. | Chondrocyte therapeutic delivery system |
US7897384B2 (en) * | 2003-09-08 | 2011-03-01 | Ethicon, Inc. | Chondrocyte therapeutic delivery system |
US8257963B2 (en) * | 2007-06-01 | 2012-09-04 | Depuy Mitek, Inc. | Chondrocyte container and method of use |
SE526959C2 (en) * | 2003-10-02 | 2005-11-29 | Tikomed Ab | Bioartificial implant comprising a semipermeable barrier and a method for reducing the risk of connective tissue formation in the implant after implantation by providing the barrier with a permeable coating of bioactive metal |
EP1558215A4 (en) * | 2003-10-14 | 2007-09-12 | Wockhardt Ltd | Sterile gelling agents |
US20050090607A1 (en) * | 2003-10-28 | 2005-04-28 | Dexcom, Inc. | Silicone composition for biocompatible membrane |
US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
US8364231B2 (en) | 2006-10-04 | 2013-01-29 | Dexcom, Inc. | Analyte sensor |
EP2228642B1 (en) * | 2003-12-08 | 2017-07-19 | DexCom, Inc. | Systems and methods for improving electrochemical analyte sensors |
EP2316331B1 (en) | 2003-12-09 | 2016-06-29 | Dexcom, Inc. | Signal processing for continuous analyte sensor |
US20050182451A1 (en) * | 2004-01-12 | 2005-08-18 | Adam Griffin | Implantable device with improved radio frequency capabilities |
WO2005079257A2 (en) * | 2004-02-12 | 2005-09-01 | Dexcom, Inc. | Biointerface with macro- and micro- architecture |
US8808228B2 (en) | 2004-02-26 | 2014-08-19 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
US8792955B2 (en) | 2004-05-03 | 2014-07-29 | Dexcom, Inc. | Transcutaneous analyte sensor |
US20050245799A1 (en) * | 2004-05-03 | 2005-11-03 | Dexcom, Inc. | Implantable analyte sensor |
US8277713B2 (en) | 2004-05-03 | 2012-10-02 | Dexcom, Inc. | Implantable analyte sensor |
US20050249772A1 (en) * | 2004-05-04 | 2005-11-10 | Prasanna Malaviya | Hybrid biologic-synthetic bioabsorbable scaffolds |
US7569233B2 (en) * | 2004-05-04 | 2009-08-04 | Depuy Products, Inc. | Hybrid biologic-synthetic bioabsorbable scaffolds |
CA2998199A1 (en) | 2004-06-01 | 2005-12-15 | Kwalata Trading Limited | Methods for use with stem cells involving culturing on a surface with antibodies |
WO2006127694A2 (en) | 2004-07-13 | 2006-11-30 | Dexcom, Inc. | Analyte sensor |
US7654956B2 (en) | 2004-07-13 | 2010-02-02 | Dexcom, Inc. | Transcutaneous analyte sensor |
EP1786834B1 (en) | 2004-07-14 | 2016-02-17 | Glusense Ltd. | Implantable power sources and sensors |
US20060067917A1 (en) * | 2004-09-20 | 2006-03-30 | Athanassios Sambanis | Insulin delivery system |
US7513866B2 (en) * | 2004-10-29 | 2009-04-07 | Depuy Products, Inc. | Intestine processing device and associated method |
US9788978B2 (en) * | 2004-12-20 | 2017-10-17 | Nicholas A. Rojo | Implantable systems and stents containing cells for therapeutic uses |
US7354627B2 (en) * | 2004-12-22 | 2008-04-08 | Depuy Products, Inc. | Method for organizing the assembly of collagen fibers and compositions formed therefrom |
US9427496B2 (en) | 2005-02-18 | 2016-08-30 | Drexel University | Method for creating an internal transport system within tissue scaffolds using computer-aided tissue engineering |
US20060246111A1 (en) * | 2005-04-19 | 2006-11-02 | Smith Larry L | Polysaccharides as ultrasound transmission media |
US20060292690A1 (en) * | 2005-06-22 | 2006-12-28 | Cesco Bioengineering Co., Ltd. | Method of making cell growth surface |
CA2616877C (en) * | 2005-07-27 | 2014-01-28 | Protiva Biotherapeutics, Inc. | Systems and methods for manufacturing liposomes |
US20070128247A1 (en) * | 2005-12-01 | 2007-06-07 | Kato Yasushi P | Method for Ionically Cross-Linking Polysaccharide Material for Thin Film Applications and Products Produced Therefrom |
TW200734462A (en) * | 2006-03-08 | 2007-09-16 | In Motion Invest Ltd | Regulating stem cells |
EP2029727B1 (en) * | 2006-06-16 | 2012-04-11 | FMC Biopolymer AS | Alginate coated, collagen matrix cellular device, preparative methods, and uses thereof. |
US7758649B2 (en) * | 2006-08-04 | 2010-07-20 | Integrity Intellect Inc. | Reversibly deformable implant |
CN101528166B (en) * | 2006-08-29 | 2014-05-07 | 阿克伦大学 | Implantable devices for producing insulin |
US20100028451A1 (en) | 2006-09-26 | 2010-02-04 | Trustees Of Tufts College | Silk microspheres for encapsulation and controlled release |
WO2008062417A2 (en) * | 2006-11-22 | 2008-05-29 | Beta O2 Technologies Ltd. | Protecting algae from body fluids |
US7871440B2 (en) * | 2006-12-11 | 2011-01-18 | Depuy Products, Inc. | Unitary surgical device and method |
EP2125056B1 (en) * | 2007-02-19 | 2015-11-18 | Ticapex AB | Implant assembly |
JP2010522583A (en) | 2007-02-27 | 2010-07-08 | トラスティーズ オブ タフツ カレッジ | Silk organs made by tissue engineering |
US20200037874A1 (en) | 2007-05-18 | 2020-02-06 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
US20080306434A1 (en) | 2007-06-08 | 2008-12-11 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
AU2008266060B2 (en) * | 2007-06-13 | 2013-08-29 | Fmc Corporation | Alginate coated, polysaccharide gel-containing foam composite, preparative methods, and uses thereof |
WO2009023615A1 (en) | 2007-08-10 | 2009-02-19 | Trustees Of Tufts College | Tubular silk compositions and methods of use thereof |
WO2009029958A2 (en) * | 2007-08-30 | 2009-03-05 | Sunstorm Research Corporation | Implantable delivery device |
US8821431B2 (en) * | 2007-09-07 | 2014-09-02 | Beta O2 Technologies Ltd. | Air gap for supporting cells |
US9452258B2 (en) | 2007-10-09 | 2016-09-27 | Dexcom, Inc. | Integrated insulin delivery system with continuous glucose sensor |
US8668863B2 (en) | 2008-02-26 | 2014-03-11 | Board Of Regents, The University Of Texas System | Dendritic macroporous hydrogels prepared by crystal templating |
US9446168B2 (en) | 2010-06-07 | 2016-09-20 | Beta-O2 Technologies Ltd. | Multiple-layer immune barrier for donor cells |
US9540630B2 (en) * | 2008-09-17 | 2017-01-10 | Beta O2 Technologies Ltd. | Optimization of alginate encapsulation of islets for transplantation |
WO2010039249A1 (en) | 2008-10-03 | 2010-04-08 | C.R. Bard, Inc. | Implantable prosthesis |
US8043271B2 (en) * | 2008-11-26 | 2011-10-25 | Beta 02 Technologies Ltd. | Apparatus for transportation of oxygen to implanted cells |
US20100160749A1 (en) * | 2008-12-24 | 2010-06-24 | Glusense Ltd. | Implantable optical glucose sensing |
JP5897335B2 (en) | 2009-01-23 | 2016-03-30 | エヌエスジーン・アクティーゼルスカブNsGene A/S | Improved cell lines and their use in encapsulated cell biodelivery |
US9277999B2 (en) | 2009-02-27 | 2016-03-08 | University of Pittsburgh—of the Commonwealth System of Higher Education | Joint bioscaffolds |
EP2475309A4 (en) | 2009-09-08 | 2015-07-29 | Atrium Medical Corp | Hernia patch |
WO2011106369A1 (en) * | 2010-02-25 | 2011-09-01 | Orteq B.V. | Meniscus repair assembly and method |
FR2962898B1 (en) * | 2010-07-22 | 2012-08-17 | Statice Sante | POCKET TO FORM AN IMPLANTABLE ARTIFICIAL BODY |
DK2621403T3 (en) | 2010-09-27 | 2015-06-15 | Nsgene As | An implantable cell device with supporting and radial diffusible structure |
US9725689B2 (en) | 2010-10-08 | 2017-08-08 | Terumo Bct, Inc. | Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system |
US9095558B2 (en) | 2010-10-08 | 2015-08-04 | Board Of Regents, The University Of Texas System | Anti-adhesive barrier membrane using alginate and hyaluronic acid for biomedical applications |
WO2012048283A1 (en) | 2010-10-08 | 2012-04-12 | Board Of Regents, The University Of Texas System | One-step processing of hydrogels for mechanically robust and chemically desired features |
ES2847578T3 (en) | 2011-04-15 | 2021-08-03 | Dexcom Inc | Advanced analyte sensor calibration and error detection |
WO2012145652A1 (en) | 2011-04-20 | 2012-10-26 | Trustees Of Tufts College | Dynamic silk coatings for implantable devices |
US9037205B2 (en) | 2011-06-30 | 2015-05-19 | Glusense, Ltd | Implantable optical glucose sensing |
CA2867464A1 (en) | 2012-03-20 | 2013-09-26 | Trustees Of Tufts College | Silk reservoirs for drug delivery |
EP2836236B1 (en) | 2012-04-13 | 2019-01-02 | Trustees Of Tufts College | Methods and compositions for preparing a silk microsphere |
US10034945B2 (en) | 2012-07-13 | 2018-07-31 | Trustees Of Tufts College | Silk powder compaction for production of constructs with high mechanical strength and stiffness |
CN104981259B (en) | 2012-12-11 | 2017-03-08 | 得克萨斯系统大学评议会 | Kit comprising the aquagel membrane for preventing adhesion |
US11565027B2 (en) | 2012-12-11 | 2023-01-31 | Board Of Regents, The University Of Texas System | Hydrogel membrane for adhesion prevention |
EP2934555B1 (en) | 2012-12-21 | 2021-09-22 | Astellas Institute for Regenerative Medicine | Methods for production of platelets from pluripotent stem cells |
WO2014112950A1 (en) * | 2013-01-18 | 2014-07-24 | Nanyang Technological University | Method of preparing a keratin-based biomaterial and keratin-based biomaterial formed thereof |
US11376329B2 (en) | 2013-03-15 | 2022-07-05 | Trustees Of Tufts College | Low molecular weight silk compositions and stabilizing silk compositions |
JP6457482B2 (en) | 2013-03-15 | 2019-01-23 | トラスティーズ オブ タフツ カレッジ | Low molecular weight silk composition and stabilization of silk composition |
WO2014176458A2 (en) | 2013-04-24 | 2014-10-30 | Trustees Of Tufts College | Bioresorbable biopolymer anastomosis devices |
CN105992816B (en) | 2013-11-16 | 2018-04-17 | 泰尔茂比司特公司 | Cell amplification in bioreactor |
JP6783143B2 (en) | 2014-03-25 | 2020-11-11 | テルモ ビーシーティー、インコーポレーテッド | Passive replenishment of medium |
WO2015191547A1 (en) * | 2014-06-09 | 2015-12-17 | Cornell University | Implantable therapeutic delivery system and methods thereof |
CN106715676A (en) | 2014-09-26 | 2017-05-24 | 泰尔茂比司特公司 | Scheduled feed |
EP3206567A1 (en) | 2014-10-13 | 2017-08-23 | Glusense, Ltd. | Analyte-sensing device |
WO2016100721A1 (en) | 2014-12-17 | 2016-06-23 | Tufts University | Injectable, flexible hydroxyapatite-silk foams for osteochondral and dental repair |
WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
US20200078495A1 (en) | 2015-07-20 | 2020-03-12 | Tufts University | Biodegradable silk ear tubes |
US10871487B2 (en) | 2016-04-20 | 2020-12-22 | Glusense Ltd. | FRET-based glucose-detection molecules |
WO2017189832A1 (en) | 2016-04-29 | 2017-11-02 | Trustees Of Tufts College | An artificial silk based innervated cornea |
EP3464565A4 (en) | 2016-05-25 | 2020-01-01 | Terumo BCT, Inc. | Cell expansion |
US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
US11298443B2 (en) | 2016-07-01 | 2022-04-12 | Trustees Of Tufts College | Innervated artificial skin |
US11248313B2 (en) | 2016-08-01 | 2022-02-15 | Trustees Of Tufts College | Biomimetic mechanical tension driven fabrication of nanofibrillar architecture |
US20200000713A1 (en) | 2017-01-20 | 2020-01-02 | Massachusetts Institute Of Technology | Injectable polymer micro-depots for controlled local drug delivery |
US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
JP7393945B2 (en) | 2017-03-31 | 2023-12-07 | テルモ ビーシーティー、インコーポレーテッド | cell proliferation |
EP3409239A1 (en) | 2017-05-29 | 2018-12-05 | University College Dublin, National University of Ireland, Dublin | An implantable active agent encapsulating device |
US11331022B2 (en) | 2017-10-24 | 2022-05-17 | Dexcom, Inc. | Pre-connected analyte sensors |
CN111246797A (en) | 2017-10-24 | 2020-06-05 | 德克斯康公司 | Pre-attached analyte sensors |
US11419947B2 (en) | 2017-10-30 | 2022-08-23 | Massachusetts Institute Of Technology | Layer-by-layer nanoparticles for cytokine therapy in cancer treatment |
US20210236644A1 (en) | 2017-11-10 | 2021-08-05 | Cocoon Biotech Inc. | Ocular applications of silk-based products |
CA3142608A1 (en) | 2019-06-04 | 2020-12-10 | Cocoon Biotech Inc. | Silk-based products, formulations, and methods of use |
AU2020352623A1 (en) | 2019-09-27 | 2022-05-12 | Isla Technologies, Inc. | Bioartificial pancreas |
EP4125963A4 (en) * | 2020-04-03 | 2024-04-17 | Brigham & Womens Hospital Inc | Implantable cell macroencapsulation device and method of manufacture and use |
JP2024507471A (en) | 2021-02-19 | 2024-02-20 | エフ. ホフマン-ラ ロシュ アーゲー | Means and methods for transplanting cells that secrete therapeutic compounds |
Family Cites Families (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3093831A (en) * | 1959-10-22 | 1963-06-18 | Jordan Gerhard Paul Wilhelm | Artificial gland |
US5141581A (en) * | 1972-10-08 | 1992-08-25 | Markham Harold A | Implants with a cover which resists formation of firm spherical encapsulation |
US4282317A (en) * | 1979-01-15 | 1981-08-04 | Roth Jonathan N | Pectin culture media and method |
US4241187A (en) * | 1979-03-27 | 1980-12-23 | United States Of America | Method and apparatus for cell and tissue culture |
US4391909A (en) * | 1979-03-28 | 1983-07-05 | Damon Corporation | Microcapsules containing viable tissue cells |
US4424132A (en) * | 1981-02-05 | 1984-01-03 | Asahi Kasei Kogyo Kabushiki Kaisha | Apparatus and method for separating blood components |
US4322298A (en) * | 1981-06-01 | 1982-03-30 | Advanced Blood Component Technology, Inc. | Centrifugal cell separator, and method of use thereof |
US4378016A (en) * | 1981-07-15 | 1983-03-29 | Biotek, Inc. | Artificial endocrine gland containing hormone-producing cells |
US4402694A (en) * | 1981-07-16 | 1983-09-06 | Biotek, Inc. | Body cavity access device containing a hormone source |
US4686098A (en) * | 1984-05-14 | 1987-08-11 | Merck & Co., Inc. | Encapsulated mouse cells transformed with avian retrovirus-bovine growth hormone DNA, and a method of administering BGH in vivo |
NO166836C (en) * | 1985-03-14 | 1991-09-11 | Univ California | PROCEDURE FOR TREATMENT OF AN ORGAN TRANSPLANT. |
US4699141A (en) * | 1986-01-16 | 1987-10-13 | Rhode Island Hospital | Neovascularization |
US5106627A (en) * | 1987-11-17 | 1992-04-21 | Brown University Research Foundation | Neurological therapy devices |
US5182111A (en) * | 1987-11-17 | 1993-01-26 | Boston University Research Foundation | In vivo delivery of active factors by co-cultured cell implants |
US4892538A (en) * | 1987-11-17 | 1990-01-09 | Brown University Research Foundation | In vivo delivery of neurotransmitters by implanted, encapsulated cells |
US5158881A (en) * | 1987-11-17 | 1992-10-27 | Brown University Research Foundation | Method and system for encapsulating cells in a tubular extrudate in separate cell compartments |
US5156844A (en) * | 1987-11-17 | 1992-10-20 | Brown University Research Foundation | Neurological therapy system |
US5283187A (en) * | 1987-11-17 | 1994-02-01 | Brown University Research Foundation | Cell culture-containing tubular capsule produced by co-extrusion |
US5015476A (en) * | 1989-08-11 | 1991-05-14 | Paravax, Inc. | Immunization implant and method |
US5116494A (en) * | 1989-08-25 | 1992-05-26 | W. R. Grace & Co.-Conn. | Artificial pancreatic perfusion device with temperature sensitive matrix |
US5459054A (en) | 1989-12-05 | 1995-10-17 | Neocrin Company | Cells encapsulated in alginate containing a high content of a- l- guluronic acid |
US5270192A (en) * | 1991-02-07 | 1993-12-14 | Monsanto Company | Biological artificial liver |
US5222982A (en) * | 1991-02-11 | 1993-06-29 | Ommaya Ayub K | Spinal fluid driven artificial organ |
WO1992013501A1 (en) * | 1991-02-11 | 1992-08-20 | Ommaya Ayub K | Spinal fluid driven artificial organ |
US5370681A (en) * | 1991-09-16 | 1994-12-06 | Atrium Medical Corporation | Polyumenal implantable organ |
AU3124793A (en) | 1991-10-29 | 1993-06-07 | Clover Consolidated, Limited | Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release |
US5545423A (en) | 1991-11-25 | 1996-08-13 | Vivorx, Inc. | Cytoprotective, biocompatible, retrievable macrocapsule containment systems for biologically active materials |
US5260002A (en) * | 1991-12-23 | 1993-11-09 | Vanderbilt University | Method and apparatus for producing uniform polymeric spheres |
US5573934A (en) * | 1992-04-20 | 1996-11-12 | Board Of Regents, The University Of Texas System | Gels for encapsulation of biological materials |
JP3011768B2 (en) | 1992-02-28 | 2000-02-21 | ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム | Photopolymerizable biodegradable hydrophilic gels as tissue contacting materials and controlled release carriers |
US5578314A (en) | 1992-05-29 | 1996-11-26 | The Regents Of The University Of California | Multiple layer alginate coatings of biological tissue for transplantation |
US5521079A (en) | 1994-01-24 | 1996-05-28 | The Regents Of The University Of California | Microcapsule generating system containing an air knife and method of encapsulating |
US5429821A (en) | 1992-05-29 | 1995-07-04 | The Regents Of The University Of California | Non-fibrogenic high mannuronate alginate coated transplants, processes for their manufacture, and methods for their use |
WO1994013266A1 (en) | 1992-05-29 | 1994-06-23 | The Regents Of The University Of California | Novel electrostatic process for manufacturing coated transplants and products |
US5425764A (en) | 1992-07-30 | 1995-06-20 | The University Of Toledo | Bioartificial pancreas |
US5387237A (en) * | 1992-07-30 | 1995-02-07 | The University Of Toledo | Bioartificial pancreas |
DE4229526B4 (en) * | 1992-09-07 | 2006-02-16 | Schrezenmeir, Jürgen, Dr. | Device for receiving and introducing biologically active tissues or cells into the human body |
US5387327A (en) * | 1992-10-19 | 1995-02-07 | Duquesne University Of The Holy Ghost | Implantable non-enzymatic electrochemical glucose sensor |
JP3338119B2 (en) * | 1993-04-14 | 2002-10-28 | 呉羽化学工業株式会社 | Antidiabetic agent |
DK0663817T3 (en) | 1993-08-10 | 2000-03-13 | Gore & Ass | cell encapsulation |
CA2169292C (en) * | 1993-08-12 | 2010-11-23 | E. Edward Baetge | Improved compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules |
EP0688196B1 (en) * | 1994-01-11 | 2002-04-17 | Baxter International Inc. | Ported tissue implant systems |
US5876742A (en) | 1994-01-24 | 1999-03-02 | The Regents Of The University Of California | Biological tissue transplant coated with stabilized multilayer alginate coating suitable for transplantation and method of preparation thereof |
US5620883A (en) | 1994-04-01 | 1997-04-15 | The Johns Hopkins University | Living cells microencapsulated in a polymeric membrane having two layers |
US5550050A (en) | 1994-04-15 | 1996-08-27 | Cytotherapeutics, Inc. | Method for implanting encapsulated cells in a host |
US5651980A (en) | 1994-04-15 | 1997-07-29 | Biohybrid Technologies, Inc. | Methods of use of uncoated gel particles |
US5776747A (en) | 1994-07-20 | 1998-07-07 | Cytotherapeutics, Inc. | Method for controlling the distribution of cells within a bioartificial organ using polycthylene oxide-poly (dimethylsiloxane) copolymer |
US5935849A (en) | 1994-07-20 | 1999-08-10 | Cytotherapeutics, Inc. | Methods and compositions of growth control for cells encapsulated within bioartificial organs |
US5510102A (en) * | 1995-01-23 | 1996-04-23 | The Regents Of The University Of California | Plasma and polymer containing surgical hemostatic adhesives |
US5916790A (en) | 1995-03-03 | 1999-06-29 | Metabolex, Inc. | Encapsulation compositions, and methods |
US5837234A (en) | 1995-06-07 | 1998-11-17 | Cytotherapeutics, Inc. | Bioartificial organ containing cells encapsulated in a permselective polyether suflfone membrane |
AU6854696A (en) | 1995-09-22 | 1997-04-09 | Gore Hybrid Technologies, Inc. | Improved cell encapsulation device |
US5855613A (en) * | 1995-10-13 | 1999-01-05 | Islet Sheet Medical, Inc. | Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change |
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1995
- 1995-10-13 US US08/542,506 patent/US5855613A/en not_active Expired - Lifetime
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1996
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- 1996-10-15 EP EP96936512A patent/EP0862391B1/en not_active Expired - Lifetime
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1998
- 1998-08-03 US US09/128,188 patent/US6165225A/en not_active Expired - Lifetime
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2000
- 2000-08-25 US US09/648,050 patent/US6372244B1/en not_active Expired - Fee Related
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CA2234233C (en) | 2007-01-16 |
US5855613A (en) | 1999-01-05 |
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AU725104B2 (en) | 2000-10-05 |
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