CA2234847A1 - Formulation for respiratory tract administration - Google Patents

Formulation for respiratory tract administration

Info

Publication number
CA2234847A1
CA2234847A1 CA002234847A CA2234847A CA2234847A1 CA 2234847 A1 CA2234847 A1 CA 2234847A1 CA 002234847 A CA002234847 A CA 002234847A CA 2234847 A CA2234847 A CA 2234847A CA 2234847 A1 CA2234847 A1 CA 2234847A1
Authority
CA
Canada
Prior art keywords
analgesic
formulation
respiratory tract
tramadol
tract administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002234847A
Other languages
French (fr)
Other versions
CA2234847C (en
Inventor
Mark Alfonso
Paul Goldenheim
Richard Sackler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euro Celtique SA
Original Assignee
Mark Alfonso
Paul Goldenheim
Richard Sackler
Euroceltique, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mark Alfonso, Paul Goldenheim, Richard Sackler, Euroceltique, S.A. filed Critical Mark Alfonso
Publication of CA2234847A1 publication Critical patent/CA2234847A1/en
Application granted granted Critical
Publication of CA2234847C publication Critical patent/CA2234847C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A dosage form for intranasal and/or inhalation administration of an analgesic having low opioid receptor binding activity to a warm blooded animal, that includes a pharmaceutically effective amount of the analgesic. A preferred analgesic is tramadol, a tramadol and/or a pharmaceutically acceptable salt, metabolite or derivative thereof. Methods of making and using the formulation according to the invention are also provided.
CA002234847A 1995-11-14 1996-11-14 Formulation for respiratory tract administration Expired - Fee Related CA2234847C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/557,279 1995-11-14
US08/557,279 US6017963A (en) 1995-11-14 1995-11-14 Formulation for intranasal administration
PCT/US1996/018904 WO1997017948A1 (en) 1995-11-14 1996-11-14 Formulation for respiratory tract administration

Publications (2)

Publication Number Publication Date
CA2234847A1 true CA2234847A1 (en) 1997-05-22
CA2234847C CA2234847C (en) 2002-06-25

Family

ID=24224765

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002234847A Expired - Fee Related CA2234847C (en) 1995-11-14 1996-11-14 Formulation for respiratory tract administration

Country Status (8)

Country Link
US (3) US6017963A (en)
EP (1) EP0877609B1 (en)
JP (1) JP3152437B2 (en)
AT (1) ATE247461T1 (en)
AU (1) AU714303B2 (en)
CA (1) CA2234847C (en)
DE (1) DE69629591T2 (en)
WO (1) WO1997017948A1 (en)

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Also Published As

Publication number Publication date
WO1997017948A1 (en) 1997-05-22
CA2234847C (en) 2002-06-25
EP0877609A1 (en) 1998-11-18
EP0877609A4 (en) 2000-06-07
JP3152437B2 (en) 2001-04-03
US6642275B2 (en) 2003-11-04
US6017963A (en) 2000-01-25
JPH11500148A (en) 1999-01-06
ATE247461T1 (en) 2003-09-15
US20020022663A1 (en) 2002-02-21
AU1060497A (en) 1997-06-05
AU714303B2 (en) 1999-12-23
EP0877609B1 (en) 2003-08-20
DE69629591T2 (en) 2004-07-01
DE69629591D1 (en) 2003-09-25
US20010049391A1 (en) 2001-12-06

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Effective date: 20121114