CA2237529A1 - Vaccine compositions for intranasal administration comprising chitosan and use thereof - Google Patents
Vaccine compositions for intranasal administration comprising chitosan and use thereofInfo
- Publication number
- CA2237529A1 CA2237529A1 CA002237529A CA2237529A CA2237529A1 CA 2237529 A1 CA2237529 A1 CA 2237529A1 CA 002237529 A CA002237529 A CA 002237529A CA 2237529 A CA2237529 A CA 2237529A CA 2237529 A1 CA2237529 A1 CA 2237529A1
- Authority
- CA
- Canada
- Prior art keywords
- chitosan
- intranasal administration
- vaccine compositions
- compositions
- antigens
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55583—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55588—Adjuvants of undefined constitution
Abstract
There is provided vaccine compositions for intranasal administration, which compositions comprise one or more antigens and an effective adjuvant amount of a chitosan.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9525083.3A GB9525083D0 (en) | 1995-12-07 | 1995-12-07 | Vaccine compositions |
GB9525083.3 | 1995-12-07 | ||
PCT/GB1996/003019 WO1997020576A1 (en) | 1995-12-07 | 1996-12-09 | Vaccine compositions for intranasal administration comprising chitosan and use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2237529A1 true CA2237529A1 (en) | 1997-06-12 |
CA2237529C CA2237529C (en) | 2008-10-14 |
Family
ID=10785093
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002237529A Expired - Fee Related CA2237529C (en) | 1995-12-07 | 1996-12-09 | Vaccine compositions for intranasal administration comprising chitosan and use thereof |
Country Status (13)
Country | Link |
---|---|
US (2) | US6391318B1 (en) |
EP (1) | EP0865297B1 (en) |
JP (1) | JP4063876B2 (en) |
AT (1) | ATE227134T1 (en) |
CA (1) | CA2237529C (en) |
DE (1) | DE69624726T2 (en) |
DK (1) | DK0865297T3 (en) |
ES (1) | ES2186809T3 (en) |
GB (2) | GB9525083D0 (en) |
NO (1) | NO323084B1 (en) |
NZ (1) | NZ323973A (en) |
PT (1) | PT865297E (en) |
WO (1) | WO1997020576A1 (en) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9419979D0 (en) * | 1994-10-04 | 1994-11-16 | Medeva Holdings Bv | Vaccine compositions |
US5993852A (en) * | 1997-08-29 | 1999-11-30 | Pharmaderm Laboratories Ltd. | Biphasic lipid vesicle composition for transdermal administration of an immunogen |
GB9725084D0 (en) * | 1997-11-28 | 1998-01-28 | Medeva Europ Ltd | Vaccine compositions |
US7022683B1 (en) * | 1998-05-13 | 2006-04-04 | Carrington Laboratories, Inc. | Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation |
JP2002540076A (en) * | 1999-03-24 | 2002-11-26 | イギリス国 | Vaccine composition |
GB9914412D0 (en) * | 1999-06-22 | 1999-08-18 | Worrall Eric E | Method for the preservation of viruses,bacteria and biomolecules |
US20030206958A1 (en) * | 2000-12-22 | 2003-11-06 | Cattaneo Maurizio V. | Chitosan biopolymer for the topical delivery of active agents |
US7767197B2 (en) | 2000-06-22 | 2010-08-03 | Endo Pharmaceuticals Colorado LLC | Delivery vehicle composition and methods for delivering antigens and other drugs |
AU2002210407A1 (en) * | 2000-10-27 | 2002-05-06 | Pharmexa A/S | Therapeutic vaccine formulations containing chitosan |
US6777000B2 (en) * | 2001-02-28 | 2004-08-17 | Carrington Laboratories, Inc. | In-situ gel formation of pectin |
US7494669B2 (en) * | 2001-02-28 | 2009-02-24 | Carrington Laboratories, Inc. | Delivery of physiological agents with in-situ gels comprising anionic polysaccharides |
ATE375786T1 (en) | 2001-08-16 | 2007-11-15 | Cmp Therapeutics Ltd | CHITIN MICROPARTICLES AND THEIR MEDICAL USE |
EP1441762A1 (en) | 2001-09-28 | 2004-08-04 | University Of South Florida | Rsv gene expression vaccine |
KR20040073438A (en) * | 2001-11-19 | 2004-08-19 | 벡톤 디킨슨 앤드 컴퍼니 | Pharmaceutical compositions in particulate form |
EP1506007B1 (en) * | 2002-05-14 | 2011-06-22 | Novartis Vaccines and Diagnostics S.r.l. | Mucosal combination vaccines for bacterial meningitis |
MXPA04011249A (en) * | 2002-05-14 | 2005-06-06 | Chiron Srl | Mucosal vaccines with chitosan adjuvant and meningococcal antigens. |
GB0302218D0 (en) * | 2003-01-30 | 2003-03-05 | Chiron Sri | Vaccine formulation & Mucosal delivery |
WO2004003145A2 (en) * | 2002-06-28 | 2004-01-08 | Nastech Pharmaceutical Company Inc. | Compositions and methods for modulating physiology of epithelial junctional adhesion molecules for enhanced mucosal delivery of therapeutic compounds |
EP1594536B1 (en) * | 2003-01-30 | 2009-03-25 | Novartis Vaccines and Diagnostics, Inc. | Adjuvanted influenza vaccine |
JP2006516609A (en) * | 2003-01-30 | 2006-07-06 | カイロン ソチエタ ア レスポンサビリタ リミタータ | Mucosal meningococcal vaccine |
CA2516188C (en) | 2003-02-14 | 2012-04-17 | University Of South Florida | Chitosan-derivatives for gene delivery and expression |
WO2004076664A2 (en) * | 2003-02-21 | 2004-09-10 | University Of South Florida | Vectors for regulating gene expression |
CA2523870A1 (en) * | 2003-04-30 | 2004-11-18 | Nastech Pharmaceutical Company Inc. | Claudins' underexpression as markers of tumor metastasis |
US20040248804A1 (en) * | 2003-05-01 | 2004-12-09 | Khurshid Iqbal | Nasal administration of the LH-RH analog Leuprolide |
EP1631308B1 (en) * | 2003-05-30 | 2013-07-31 | Amylin Pharmaceuticals, LLC | Novel methods and compositions for enhanced transmucosal delivery of peptides and proteins |
GB0315632D0 (en) | 2003-07-04 | 2003-08-13 | West Pharm Serv Drug Res Ltd | Pharmaceutical formulations |
CA2548150A1 (en) | 2003-12-04 | 2005-06-23 | University Of South Florida | Polynucleotides for reducing respiratory syncytial virus gene expression |
US7968122B2 (en) * | 2003-12-10 | 2011-06-28 | Adventrx Pharmaceuticals, Inc. | Anti-viral pharmaceutical compositions |
US20050129679A1 (en) * | 2003-12-15 | 2005-06-16 | Nastech Pharmaceutical Company Inc. | Method for opening tight junctions |
US7740883B2 (en) * | 2004-03-28 | 2010-06-22 | University Of Debrecen | Nanoparticles from chitosan |
JP2007536259A (en) * | 2004-05-06 | 2007-12-13 | イヴレア ファーマスーティカルズ インコーポレイテッド | Particles for active drug delivery |
US20090069226A1 (en) * | 2004-05-28 | 2009-03-12 | Amylin Pharmaceuticals, Inc. | Transmucosal delivery of peptides and proteins |
US20050283004A1 (en) | 2004-06-18 | 2005-12-22 | Hopax Chemicals Manufacturing Co., Ltd. | Alkylsulfonated polyaminosaccharides |
WO2006030730A1 (en) * | 2004-09-15 | 2006-03-23 | Otsuka Pharmaceutical Co., Ltd. | Permucosal composition and method of improving permucosal absorption |
WO2007086923A2 (en) * | 2005-05-23 | 2007-08-02 | University Of South Florida | Controlled and sustained gene transfer mediated by thiol-modified polymers |
US20080184618A1 (en) * | 2005-08-03 | 2008-08-07 | Amcol International | Virus-Interacting Layered Phyllosilicates and Methods of Use |
US20070031512A1 (en) * | 2005-08-03 | 2007-02-08 | Amcol International Corporation | Virus-interacting layered phyllosilicates and methods of inactivating viruses |
US20100272769A1 (en) * | 2005-08-03 | 2010-10-28 | Amcol International | Virus-, Bacteria-, and Fungi-Interacting Layered Phyllosilicates and Methods of Use |
US8536324B2 (en) * | 2005-10-21 | 2013-09-17 | University Of South Florida | Method of drug delivery by carbon nanotube-chitosan nanocomplexes |
EP1948810A4 (en) * | 2005-11-04 | 2010-06-30 | Biosyntech Canada Inc | Composition and method for efficient delivery of nucleic acids to cells using chitosan |
CA2635603C (en) | 2005-11-30 | 2016-01-19 | Endo Pharmaceuticals Inc. | Treatment of xerostomia |
US8846102B2 (en) * | 2006-03-30 | 2014-09-30 | Engene, Inc. | Non-viral compositions and methods for transfecting gut cells in vivo |
AU2007262845B2 (en) | 2006-06-20 | 2013-07-25 | Mucovax Inc. | Compositions comprising chitin microparticles and their medical uses |
CA2664157C (en) | 2006-09-29 | 2015-12-01 | Ligocyte Pharmaceuticals, Inc. | Norovirus vaccine formulations |
EP2112923A1 (en) | 2007-01-22 | 2009-11-04 | Targacept Inc. | Intranasal, buccal, and sublingual administration of metanicotine analogs |
US20080182819A1 (en) * | 2007-01-29 | 2008-07-31 | Act Iii Licensing, Llc | Chitosan compositions and methods for using chitosan compositions in the treatment of health disorders |
WO2008147807A2 (en) | 2007-05-23 | 2008-12-04 | Amcol International Corporation | Cholesterol-interacting layered phyllosilicates and methods of reducing hypercholesteremia in a mammal |
JP2010539192A (en) | 2007-09-18 | 2010-12-16 | リゴサイト ファーマスーティカルズ,インコーポレイテッド | Methods for conferring a protective immune response against norovirus |
US20100266636A1 (en) * | 2007-09-18 | 2010-10-21 | Ligocyte Pharmaceuticals, Inc. | Method of conferring a protective immune response to norovirus |
BRPI0905725B8 (en) * | 2008-01-11 | 2021-05-25 | Univ Emory | vaccine and pharmaceutical packaging |
WO2009108867A1 (en) | 2008-02-27 | 2009-09-03 | Amcol International Corporation | Methods of treating cardiovascular disorders associated with atherosclerosis |
ES2668836T3 (en) | 2008-08-08 | 2018-05-22 | Takeda Vaccines, Inc. | Similiviral particles comprising amino acid sequences of the compound capsid for enhanced cross-reactivity |
WO2010119112A1 (en) * | 2009-04-15 | 2010-10-21 | Ceva Sante Animale | Recombinant avian herpes virus vectors and vaccine for immunizing waterfowl species |
CA2841356C (en) | 2011-07-11 | 2022-03-01 | Takeda Vaccines, Inc. | Parenteral norovirus vaccine formulations |
ES2932952T3 (en) | 2012-04-24 | 2023-01-30 | Ohio State Innovation Foundation | Compositions and methods for treating and preventing porcine reproductive and respiratory syndrome |
US10279028B2 (en) | 2012-04-24 | 2019-05-07 | Ohio State Innovation Foundation | Compositions and methods for treating and preventing porcine reproductive and respiratory syndrome |
CN108715607B (en) * | 2018-04-12 | 2021-12-10 | 华南农业大学 | Recombinant cholera toxin B subunit protein, PEDV inactivated vaccine, preparation and application |
CN109172817B (en) * | 2018-08-16 | 2021-10-26 | 华中农业大学 | Preparation method and application of chitosan microspheres of attenuated live vaccine of porcine epidemic diarrhea virus |
EP3698773A1 (en) | 2019-02-21 | 2020-08-26 | Università degli Studi di Parma | Composition and manufacturing of powders containing nanoadjuvants for mucosal vaccination |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1261264A (en) * | 1984-11-29 | 1989-09-26 | Shigeo Suzuki | Immunopotentiating agents and method |
US4950740A (en) * | 1987-03-17 | 1990-08-21 | Cetus Corporation | Recombinant diphtheria vaccines |
US5554388A (en) * | 1989-02-25 | 1996-09-10 | Danbiosyst Uk Limited | Systemic drug delivery compositions comprising a polycationi substance |
GB8904370D0 (en) * | 1989-02-25 | 1989-04-12 | Cosmas Damian Ltd | Liquid delivery compositions |
GB9202464D0 (en) * | 1992-02-05 | 1992-03-18 | Danbiosyst Uk | Composition for nasal administration |
US5912000A (en) * | 1994-09-23 | 1999-06-15 | Zonagen, Inc. | Chitosan induced immunopotentiation |
WO1996009805A2 (en) | 1994-09-23 | 1996-04-04 | Zonagen, Inc. | Chitosan induced immunopotentiation |
GB9419979D0 (en) | 1994-10-04 | 1994-11-16 | Medeva Holdings Bv | Vaccine compositions |
JP2001523216A (en) * | 1995-06-26 | 2001-11-20 | リサーチ.トライアングル.ファーマシューティカルズ | Novel adjuvant composition and vaccine formulation comprising the same |
GB9522351D0 (en) * | 1995-11-01 | 1996-01-03 | Medeva Holdings Bv | Vaccine compositions |
-
1995
- 1995-12-07 GB GBGB9525083.3A patent/GB9525083D0/en active Pending
-
1996
- 1996-12-09 DK DK96941743T patent/DK0865297T3/en active
- 1996-12-09 JP JP52109497A patent/JP4063876B2/en not_active Expired - Fee Related
- 1996-12-09 ES ES96941743T patent/ES2186809T3/en not_active Expired - Lifetime
- 1996-12-09 CA CA002237529A patent/CA2237529C/en not_active Expired - Fee Related
- 1996-12-09 GB GB9811810A patent/GB2322801B/en not_active Expired - Fee Related
- 1996-12-09 DE DE69624726T patent/DE69624726T2/en not_active Expired - Lifetime
- 1996-12-09 WO PCT/GB1996/003019 patent/WO1997020576A1/en active IP Right Grant
- 1996-12-09 EP EP96941743A patent/EP0865297B1/en not_active Expired - Lifetime
- 1996-12-09 NZ NZ323973A patent/NZ323973A/en not_active IP Right Cessation
- 1996-12-09 PT PT96941743T patent/PT865297E/en unknown
- 1996-12-09 AT AT96941743T patent/ATE227134T1/en active
-
1998
- 1998-06-01 US US09/088,185 patent/US6391318B1/en not_active Expired - Lifetime
- 1998-06-02 NO NO19982497A patent/NO323084B1/en not_active IP Right Cessation
-
2002
- 2002-05-08 US US10/141,312 patent/US7323183B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
GB9811810D0 (en) | 1998-07-29 |
ES2186809T3 (en) | 2003-05-16 |
NZ323973A (en) | 2004-12-24 |
US7323183B2 (en) | 2008-01-29 |
DK0865297T3 (en) | 2003-03-03 |
GB2322801A (en) | 1998-09-09 |
GB9525083D0 (en) | 1996-02-07 |
ATE227134T1 (en) | 2002-11-15 |
AU705452B2 (en) | 1999-05-20 |
JP2000501412A (en) | 2000-02-08 |
JP4063876B2 (en) | 2008-03-19 |
PT865297E (en) | 2003-03-31 |
WO1997020576A1 (en) | 1997-06-12 |
DE69624726T2 (en) | 2003-09-18 |
GB2322801B (en) | 2000-01-19 |
US6391318B1 (en) | 2002-05-21 |
EP0865297A1 (en) | 1998-09-23 |
CA2237529C (en) | 2008-10-14 |
NO982497L (en) | 1998-06-02 |
US20030039665A1 (en) | 2003-02-27 |
NO982497D0 (en) | 1998-06-02 |
AU1102597A (en) | 1997-06-27 |
EP0865297B1 (en) | 2002-11-06 |
DE69624726D1 (en) | 2002-12-12 |
NO323084B1 (en) | 2006-12-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20161209 |