CA2241981A1 - Method of inhibiting photoaging of skin - Google Patents

Method of inhibiting photoaging of skin

Info

Publication number
CA2241981A1
CA2241981A1 CA002241981A CA2241981A CA2241981A1 CA 2241981 A1 CA2241981 A1 CA 2241981A1 CA 002241981 A CA002241981 A CA 002241981A CA 2241981 A CA2241981 A CA 2241981A CA 2241981 A1 CA2241981 A1 CA 2241981A1
Authority
CA
Canada
Prior art keywords
skin
photoaging
exposure
uvb irradiation
administering
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002241981A
Other languages
French (fr)
Other versions
CA2241981C (en
Inventor
John J. Voorhees
Gary J. Fisher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Michigan
Original Assignee
The University Of Michigan
John J. Voorhees
Gary J. Fisher
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24355242&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2241981(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by The University Of Michigan, John J. Voorhees, Gary J. Fisher filed Critical The University Of Michigan
Publication of CA2241981A1 publication Critical patent/CA2241981A1/en
Application granted granted Critical
Publication of CA2241981C publication Critical patent/CA2241981C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists

Abstract

Photoaging of undamaged skin due to UVB irradiation exposure is inhibited by administering an agent that inhibits at least one of (1) the activity of UVB irradiation inducible MMPs in the skin, (2) one or both of the transcription factors AP-1 and NF-.lambda.B or (3) at least one of the GTP binding proteins or kinases involved in the activation and/or production of jun or fos proteins that comprise AP-1; and topically administering said inhibitor to the skin prior to such exposure.
CA002241981A 1996-01-19 1997-01-17 Method of inhibiting photoaging of skin Expired - Lifetime CA2241981C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/588,771 US5837224A (en) 1996-01-19 1996-01-19 Method of inhibiting photoaging of skin
US08/588,771 1996-01-19
PCT/US1997/000791 WO1997025969A1 (en) 1996-01-19 1997-01-17 Method of inhibiting photoaging of skin

Publications (2)

Publication Number Publication Date
CA2241981A1 true CA2241981A1 (en) 1997-07-24
CA2241981C CA2241981C (en) 2002-03-19

Family

ID=24355242

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002241981A Expired - Lifetime CA2241981C (en) 1996-01-19 1997-01-17 Method of inhibiting photoaging of skin

Country Status (21)

Country Link
US (1) US5837224A (en)
EP (1) EP0883398A4 (en)
JP (1) JP3705820B2 (en)
CN (1) CN1086937C (en)
AR (1) AR005650A1 (en)
BR (1) BR9707018A (en)
CA (1) CA2241981C (en)
CO (1) CO4770951A1 (en)
CZ (1) CZ291530B6 (en)
EE (1) EE9800216A (en)
HK (1) HK1018885A1 (en)
HU (1) HUP9900655A3 (en)
LT (1) LT4515B (en)
MY (1) MY119711A (en)
NO (1) NO983019L (en)
NZ (1) NZ330860A (en)
PL (1) PL327827A1 (en)
SI (1) SI9720015A (en)
SK (1) SK95998A3 (en)
TR (1) TR199801376T2 (en)
WO (1) WO1997025969A1 (en)

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Also Published As

Publication number Publication date
JP3705820B2 (en) 2005-10-12
US5837224A (en) 1998-11-17
JP2000503660A (en) 2000-03-28
PL327827A1 (en) 1999-01-04
NO983019L (en) 1998-08-19
HK1018885A1 (en) 2000-01-07
LT4515B (en) 1999-06-25
HUP9900655A1 (en) 1999-07-28
AR005650A1 (en) 1999-07-14
CZ225898A3 (en) 1998-10-14
BR9707018A (en) 1999-07-20
SI9720015A (en) 1999-10-31
WO1997025969A1 (en) 1997-07-24
CN1211178A (en) 1999-03-17
EP0883398A1 (en) 1998-12-16
NO983019D0 (en) 1998-06-29
AU1831797A (en) 1997-08-11
AU701132B2 (en) 1999-01-21
CZ291530B6 (en) 2003-03-12
LT98091A (en) 1999-02-25
MY119711A (en) 2005-07-29
CO4770951A1 (en) 1999-04-30
NZ330860A (en) 1999-11-29
EP0883398A4 (en) 1999-05-12
CA2241981C (en) 2002-03-19
TR199801376T2 (en) 1998-10-21
CN1086937C (en) 2002-07-03
HUP9900655A3 (en) 2000-09-28
SK95998A3 (en) 1999-01-11
EE9800216A (en) 1999-04-15

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