CA2242986A1 - Sustained release drug formulations - Google Patents

Sustained release drug formulations

Info

Publication number
CA2242986A1
CA2242986A1 CA002242986A CA2242986A CA2242986A1 CA 2242986 A1 CA2242986 A1 CA 2242986A1 CA 002242986 A CA002242986 A CA 002242986A CA 2242986 A CA2242986 A CA 2242986A CA 2242986 A1 CA2242986 A1 CA 2242986A1
Authority
CA
Canada
Prior art keywords
sustained release
release drug
drug
drug formulations
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002242986A
Other languages
French (fr)
Other versions
CA2242986C (en
Inventor
Jean-Marc Ruiz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Pharma SAS
Original Assignee
Delab
Jean-Marc Ruiz
Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delab, Jean-Marc Ruiz, Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. filed Critical Delab
Publication of CA2242986A1 publication Critical patent/CA2242986A1/en
Application granted granted Critical
Publication of CA2242986C publication Critical patent/CA2242986C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Abstract

A sustained release drug formulation including: a drug; a biodegradable polymer which is insoluble in water; and an oil vehicle in which both the drug and the polymer are dissolved. The oil vehicle contains 10-100 % by volume of a pharmaceutically acceptable oil and 0-90 % by volume of a pharmaceutically acceptable liquid carrier for the drug or the polymer.
CA002242986A 1996-01-16 1997-01-15 Sustained release drug formulations Expired - Fee Related CA2242986C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/584,320 US5980945A (en) 1996-01-16 1996-01-16 Sustained release drug formulations
US08/584,320 1996-01-16
PCT/IB1997/000014 WO1997026015A1 (en) 1996-01-16 1997-01-15 Sustained release drug formulations

Publications (2)

Publication Number Publication Date
CA2242986A1 true CA2242986A1 (en) 1997-07-24
CA2242986C CA2242986C (en) 2004-09-21

Family

ID=24336839

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002242986A Expired - Fee Related CA2242986C (en) 1996-01-16 1997-01-15 Sustained release drug formulations

Country Status (10)

Country Link
US (1) US5980945A (en)
EP (1) EP0874642B1 (en)
AT (1) ATE238813T1 (en)
AU (1) AU1206497A (en)
CA (1) CA2242986C (en)
DE (1) DE69721481T2 (en)
DK (1) DK0874642T3 (en)
ES (1) ES2197982T3 (en)
PT (1) PT874642E (en)
WO (1) WO1997026015A1 (en)

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PT874642E (en) 2003-09-30
DE69721481D1 (en) 2003-06-05
EP0874642B1 (en) 2003-05-02
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ATE238813T1 (en) 2003-05-15
US5980945A (en) 1999-11-09
AU1206497A (en) 1997-08-11
DE69721481T2 (en) 2004-04-15
WO1997026015A1 (en) 1997-07-24
EP0874642A1 (en) 1998-11-04
ES2197982T3 (en) 2004-01-16

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