CA2247009A1 - Cryptic peptides and method for their identification - Google Patents
Cryptic peptides and method for their identificationInfo
- Publication number
- CA2247009A1 CA2247009A1 CA002247009A CA2247009A CA2247009A1 CA 2247009 A1 CA2247009 A1 CA 2247009A1 CA 002247009 A CA002247009 A CA 002247009A CA 2247009 A CA2247009 A CA 2247009A CA 2247009 A1 CA2247009 A1 CA 2247009A1
- Authority
- CA
- Canada
- Prior art keywords
- peptide
- cells
- challenge
- identification
- challenged
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 9
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 7
- 230000009257 reactivity Effects 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
- C07K14/43531—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from mites
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
The invention provides a method of determining whether a peptide of a protein is a cryptic peptide, which method includes the steps of i) exposing T cells with the peptide in a primary challenge; ii) measuring the reactivity of T cells with the peptide in the primary challenge of step i); iii) exposing pre-challenged T cells with the peptide in a secondary challenge, wherein the pre-challenged T cells are obtainable by exposing the T cells to the protein; and measuring the reactivity of the pre-challenged T cells with the peptide in the secondary challenge of step iii), and the peptide is a cryptic peptide if T-cell reactivity is observable in the secondary challenge but not in the primary challenge.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9605904.3A GB9605904D0 (en) | 1996-03-21 | 1996-03-21 | Peptides |
GB9605904.3 | 1996-03-21 | ||
GB9608430.6 | 1996-04-24 | ||
GBGB9608430.6A GB9608430D0 (en) | 1996-04-24 | 1996-04-24 | Peptides |
PCT/GB1997/000783 WO1997035193A1 (en) | 1996-03-21 | 1997-03-20 | Cryptic peptides and method for their identification |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2247009A1 true CA2247009A1 (en) | 1997-09-25 |
CA2247009C CA2247009C (en) | 2009-08-04 |
Family
ID=26308965
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002247009A Expired - Lifetime CA2247009C (en) | 1996-03-21 | 1997-03-20 | Cryptic peptides and method for their identification |
Country Status (11)
Country | Link |
---|---|
US (1) | US6737406B1 (en) |
EP (2) | EP0888541B1 (en) |
JP (1) | JP4340329B2 (en) |
AT (2) | ATE296444T1 (en) |
AU (1) | AU730198C (en) |
CA (1) | CA2247009C (en) |
DE (2) | DE69733343D1 (en) |
DK (1) | DK1612555T3 (en) |
ES (1) | ES2314515T3 (en) |
GB (3) | GB2352518B (en) |
WO (1) | WO1997035193A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2812087B1 (en) | 2000-07-21 | 2007-05-11 | Inst Nat Sante Rech Med | METHOD OF SCREENING PEPTIDES USED IN IMMUNOTHERAPY |
JPWO2002066979A1 (en) * | 2001-02-22 | 2004-06-24 | タカラバイオ株式会社 | Method for detecting antigen causing bronchial asthma |
PT1512004E (en) * | 2002-06-11 | 2006-08-31 | Merck Patent Gmbh | METHOD FOR MAPPING AND ELIMINATING EPITHOPES FOR T-CELLS |
GB0710529D0 (en) | 2007-06-01 | 2007-07-11 | Circassia Ltd | Vaccine |
EP2286833A3 (en) * | 2007-08-15 | 2011-09-14 | Circassia Limited | Peptides for desensibilization against allergens |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2633881B2 (en) | 1986-06-30 | 1997-07-23 | マサチューセッツ インスティテュート オブ テクノロジー | Immunomodulatory compositions and their use |
US5019384A (en) | 1986-06-30 | 1991-05-28 | Massachusetts Institute Of Technology | Immunonodulating compositions and their use |
US6180368B1 (en) | 1988-03-23 | 2001-01-30 | University Of Melbourne | Ryegrass pollen allergen |
ATE175209T1 (en) | 1989-03-17 | 1999-01-15 | Immulogic Pharma Corp | ALLERGIC PROTEINS FROM AMBROSIA AND USE THEREOF |
US5547669A (en) | 1989-11-03 | 1996-08-20 | Immulogic Pharma Corp | Recombinant peptides comprising T cell epitopes of the cat allergen, Fel d I |
DK0500785T3 (en) | 1989-11-03 | 2002-08-19 | Immulogic Pharma Corp | Human T cell activity feline protein (TRFP) isolated from house dust as well as applications thereof |
US6019972A (en) | 1989-11-03 | 2000-02-01 | Immulogic Pharmaceutical Corporation | Peptides of human T cell reactive feline protein (TRFP) |
US5328991A (en) | 1989-11-03 | 1994-07-12 | Immulogic Pharmaceutical Corp. | Preparation of alkali-modified cat dander allergen (Fel d I) for immunotherapeutic purposes |
US5433948A (en) | 1990-02-13 | 1995-07-18 | Thomas; Wayne R. | Cloning and sequencing of allergens of dermatophagoides (house dust mite) |
ES2133288T3 (en) | 1990-09-11 | 1999-09-16 | Inst Child Health Research | CLONING AND SEQUENCING OF DERMATOPHAGOID ALLERGENS (HOUSEHOLD MITES). |
CA2095323A1 (en) | 1990-10-30 | 1992-05-01 | Jonathan B. Rothbard | Peptide binding assays with mhc antigens |
WO1992011859A1 (en) | 1991-01-08 | 1992-07-23 | Immulogic Pharmaceutical Corporation | Peptide-mediated hyposensitization of the human t cell response to dermatophagoides spp. (house dust mite) |
EP0595855A1 (en) | 1991-07-12 | 1994-05-11 | Immulogic Pharmaceutical Corporation | Allergenic proteins and peptides from japanese cedar pollen |
WO1994001560A1 (en) | 1991-07-12 | 1994-01-20 | Immulogic Pharmaceutical Corporation | Allergenic proteins and peptides from japanese cedar pollen |
WO1994024281A1 (en) | 1993-04-14 | 1994-10-27 | Immulogic Pharmaceutical Corporation | T cell epitopes of the major allergens from dermatophagoides (house dust mite) |
NZ299122A (en) | 1991-10-16 | 2005-02-25 | Immulogic Pharma Corp | Detecting and treating allergies using peptides with T-cell stimulating activity |
ATE444360T1 (en) | 1991-10-16 | 2009-10-15 | Merck Patent Gmbh | T-CELL EPITOPES FROM THE MAIN ALLERGENS OF DERMATOPHAGOIDES (HOUSE MITES) |
IL105153A (en) * | 1992-03-25 | 1999-12-22 | Immulogic Pharma Corp | Therapeutic compositions comprising peptides derived from human t cell reactive feline protein |
CA2117779A1 (en) | 1992-04-09 | 1993-10-28 | Mei-Chang Kuo | T cell epitopes of the major allergens from ambrosia artemisifolia |
WO1994003478A1 (en) | 1992-07-31 | 1994-02-17 | Immulogic Pharmaceutical Corporation | Sensitive assay for antigens and antibodies and its use to identify rheumatoid arthritis antigen |
WO1994011512A2 (en) | 1992-11-12 | 1994-05-26 | Immulogic Pharmaceutical Corporation | Allergenic proteins and peptides from japanese cedar pollen |
DK0677105T3 (en) | 1992-12-31 | 2006-07-10 | Immulogic Pharma Corp | Allergy-causing proteins and peptides from dog bark and applications therefor |
AU684501B2 (en) | 1993-03-12 | 1997-12-18 | Immulogic Pharmaceutical Corporation | T cell epitopes of ryegrass pollen allergen |
NZ266739A (en) * | 1993-06-02 | 1997-07-27 | Tvw Telethon Inst Child Health | Inducing immunologic tolerance by administering a cryptic peptide derived from the antigen der pi |
NZ271818A (en) | 1993-08-13 | 1997-11-24 | Immulogic Pharma Corp | T cell epitopes of ryegrass pollen antigen |
AU2238395A (en) | 1994-04-01 | 1995-10-23 | Immulogic Pharmaceutical Corporation | Haptenated peptides and uses thereof |
ES2285703T3 (en) | 1994-04-14 | 2007-11-16 | Merck Patent Gmbh | PHARMACEUTICAL FORMULATIONS OF PEPTIDES FOR THE TREATMENT OF ALLERGY TO THE POWDER. |
WO1996007428A1 (en) * | 1994-09-02 | 1996-03-14 | Immulogic Pharmaceutical Corporation | Peptide compositions capable of down regulating an antigen specific immune response |
WO1996012737A2 (en) | 1994-10-25 | 1996-05-02 | Immulogic Pharmaceutical Corporation | Compositions and treatment for multiple sclerosis |
AU4146796A (en) | 1994-10-27 | 1996-05-23 | Immulogic Pharmaceutical Corporation | T cell epitopes of the major allergens from ambrosia artemisiifolia |
AU4695296A (en) | 1995-01-06 | 1996-07-24 | Immulogic Pharmaceutical Corporation | Compositions and methods for treating rheumatoid arthritis |
WO1997032600A1 (en) | 1996-03-10 | 1997-09-12 | Meiji Milk Products Co., Ltd. | Peptide-base immunotherapeutic agent for allergic diseases |
US5804201A (en) | 1996-03-11 | 1998-09-08 | The Rockefeller University | Immunomodulatory peptides of vespid antigen 5 |
-
1997
- 1997-03-20 ES ES05011041T patent/ES2314515T3/en not_active Expired - Lifetime
- 1997-03-20 JP JP53327097A patent/JP4340329B2/en not_active Expired - Lifetime
- 1997-03-20 AU AU20365/97A patent/AU730198C/en not_active Expired
- 1997-03-20 GB GB0027373A patent/GB2352518B/en not_active Expired - Fee Related
- 1997-03-20 US US09/142,885 patent/US6737406B1/en not_active Expired - Lifetime
- 1997-03-20 EP EP97908389A patent/EP0888541B1/en not_active Expired - Lifetime
- 1997-03-20 CA CA002247009A patent/CA2247009C/en not_active Expired - Lifetime
- 1997-03-20 WO PCT/GB1997/000783 patent/WO1997035193A1/en active IP Right Grant
- 1997-03-20 EP EP05011041A patent/EP1612555B1/en not_active Expired - Lifetime
- 1997-03-20 GB GB0020260A patent/GB2349463B/en not_active Expired - Fee Related
- 1997-03-20 GB GB9817461A patent/GB2326642B/en not_active Expired - Lifetime
- 1997-03-20 AT AT97908389T patent/ATE296444T1/en not_active IP Right Cessation
- 1997-03-20 DE DE69733343T patent/DE69733343D1/en not_active Expired - Lifetime
- 1997-03-20 AT AT05011041T patent/ATE412175T1/en active
- 1997-03-20 DE DE69739062T patent/DE69739062D1/en not_active Expired - Lifetime
- 1997-03-20 DK DK05011041T patent/DK1612555T3/en active
Also Published As
Publication number | Publication date |
---|---|
GB0020260D0 (en) | 2000-10-04 |
WO1997035193A1 (en) | 1997-09-25 |
GB2352518B (en) | 2001-04-04 |
AU730198C (en) | 2002-03-14 |
GB0027373D0 (en) | 2000-12-27 |
EP1612555A1 (en) | 2006-01-04 |
JP2000508627A (en) | 2000-07-11 |
DE69733343D1 (en) | 2005-06-30 |
EP0888541B1 (en) | 2005-05-25 |
US6737406B1 (en) | 2004-05-18 |
ES2314515T3 (en) | 2009-03-16 |
EP0888541A1 (en) | 1999-01-07 |
GB2349463A (en) | 2000-11-01 |
JP4340329B2 (en) | 2009-10-07 |
DE69739062D1 (en) | 2008-12-04 |
ATE412175T1 (en) | 2008-11-15 |
CA2247009C (en) | 2009-08-04 |
AU2036597A (en) | 1997-10-10 |
DK1612555T3 (en) | 2009-02-09 |
ATE296444T1 (en) | 2005-06-15 |
GB9817461D0 (en) | 1998-10-07 |
AU730198B2 (en) | 2001-03-01 |
GB2326642A (en) | 1998-12-30 |
GB2352518A (en) | 2001-01-31 |
GB2349463B (en) | 2001-01-10 |
GB2326642B (en) | 2001-02-07 |
EP1612555B1 (en) | 2008-10-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK261386A (en) | MONOCLONAL ANTIBODIES | |
DK0473961T3 (en) | Immunoassay reagents and method for the determination of cyclosporin | |
CA2263129A1 (en) | Mammalian cell surface antigens; related reagents | |
CA2054798A1 (en) | Hcv-specific peptides, agents therefor and the use thereof | |
MY102885A (en) | Method for determining mimotopes. | |
CA2255659A1 (en) | Neuroactive peptides | |
AU4761493A (en) | Peptides containing respective amino acid sequences selected from among those of lipoprotein(a) and apolipoprotein(a), antibodies respectively recognizing these amino acid sequences, and method of assaying with these antibodies | |
DE69603656T2 (en) | Gastight secondary cell | |
AU5320086A (en) | Monoclonal antibodies against core proteins of lymphadenopathy-associated-viruses | |
AU7158398A (en) | Use of lentiviral vectors for antigen presentation in dendritic cells | |
AU3460697A (en) | Process for preparing hydrogen-containing gas for fuel cell | |
CA2247009A1 (en) | Cryptic peptides and method for their identification | |
DE69617396D1 (en) | Peptides affecting T cells | |
EP1652918A3 (en) | Methods for detecting protein interactions using conformationally constrained peptides | |
AU3623197A (en) | Peptide reagent for the detection of human cytomegalovirus (cmv) | |
WO1998039421A3 (en) | Mammalian proteinases; oxidoreductases; gtp binding proteins; related reagents | |
EP0253325A3 (en) | Oncogene-related peptides | |
GB9816514D0 (en) | Novel method | |
CA2100586A1 (en) | Htlv-i and htlv-ii peptide antigens and methods | |
AU2284997A (en) | Marker for male infertility and/or fertility | |
WO1997004311A3 (en) | Cell sorting with fluorescent peptides | |
DE69534178D1 (en) | S?ugetier thymokingene | |
WO1996040763A3 (en) | Peptides for hiv-1 detection | |
EP0267622A3 (en) | Method for detecting anti-adult t cell leukemia virus antibody | |
AU5171496A (en) | Method of identifying clonal cell samples |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20170320 |