CA2251169A1 - Quaternary cytofectins - Google Patents
Quaternary cytofectinsInfo
- Publication number
- CA2251169A1 CA2251169A1 CA002251169A CA2251169A CA2251169A1 CA 2251169 A1 CA2251169 A1 CA 2251169A1 CA 002251169 A CA002251169 A CA 002251169A CA 2251169 A CA2251169 A CA 2251169A CA 2251169 A1 CA2251169 A1 CA 2251169A1
- Authority
- CA
- Canada
- Prior art keywords
- quaternary
- lipids
- cytofectins
- transfective
- derivatized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/08—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Cationic lipids, having a derivatized quaternary ammonium head group, that provide improved cell targeting ability and enhanced transfective efficacy for the delivery of molecules into cells. The lipids comprise a linker having funtional groups that provide sites for further attachment of drugs, cell receptor ligands or other bioactive agents.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/629,965 US5994317A (en) | 1996-04-09 | 1996-04-09 | Quaternary cytofectins |
US08/629,965 | 1996-04-09 | ||
PCT/US1997/005757 WO1997037966A1 (en) | 1996-04-09 | 1997-04-08 | Quaternary cytofectins |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2251169A1 true CA2251169A1 (en) | 1997-10-16 |
CA2251169C CA2251169C (en) | 2006-12-19 |
Family
ID=24525211
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002251169A Expired - Fee Related CA2251169C (en) | 1996-04-09 | 1997-04-08 | Quaternary cytofectins |
Country Status (9)
Country | Link |
---|---|
US (1) | US5994317A (en) |
EP (1) | EP0902780B1 (en) |
JP (1) | JP4031045B2 (en) |
AT (1) | ATE207874T1 (en) |
CA (1) | CA2251169C (en) |
DE (1) | DE69707870T2 (en) |
DK (1) | DK0902780T3 (en) |
ES (1) | ES2166540T3 (en) |
WO (1) | WO1997037966A1 (en) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6214804B1 (en) | 1989-03-21 | 2001-04-10 | Vical Incorporated | Induction of a protective immune response in a mammal by injecting a DNA sequence |
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
US6673776B1 (en) | 1989-03-21 | 2004-01-06 | Vical Incorporated | Expression of exogenous polynucleotide sequences in a vertebrate, mammal, fish, bird or human |
US6867195B1 (en) | 1989-03-21 | 2005-03-15 | Vical Incorporated | Lipid-mediated polynucleotide administration to reduce likelihood of subject's becoming infected |
ES2113371T3 (en) | 1989-11-16 | 1998-05-01 | Univ Duke | TRANSFORMATION OF EPIDERMIC CELLS FROM ANIMAL TISSUES WITH THE HELP OF PARTICLES. |
US6706694B1 (en) | 1990-03-21 | 2004-03-16 | Vical Incorporated | Expression of exogenous polynucleotide sequences in a vertebrate |
US6228844B1 (en) | 1991-11-12 | 2001-05-08 | Vical Incorporated | Stimulating vascular growth by administration of DNA sequences encoding VEGF |
US7105574B1 (en) | 1999-03-26 | 2006-09-12 | Vical Incorporated | Adjuvant compositions and methods for enhancing immune responses to polynucleotide-based vaccines |
EP1987845B1 (en) * | 1997-11-20 | 2012-03-21 | Vical Incorporated | Treatment of cancer using cytokine-expressing polynucleotides and compositions therefor. |
US20040120891A1 (en) | 1998-12-21 | 2004-06-24 | Craig Hill | Compounds for intracellular delivery of therapeutic moieties to nerve cells |
US6652864B1 (en) | 1998-12-21 | 2003-11-25 | Asilomar Pharmaceuticals, Inc. | Compounds for intracellular delivery of therapeutic moieties to nerve cells |
WO2000057917A2 (en) * | 1999-03-26 | 2000-10-05 | Vical Incorporated | Adjuvant compositions and methods for enhancing immune responses to polynucleotide-based vaccines |
WO2001017945A1 (en) * | 1999-09-03 | 2001-03-15 | The Procter & Gamble Company | Cationic alkyl alkoxylate derivatives |
EP1278551A2 (en) * | 2000-04-21 | 2003-01-29 | Vical Incorporated | Compositions and methods for (in vivo) delivery of polynucleotide-based therapeutics |
US20040204379A1 (en) * | 2000-06-19 | 2004-10-14 | Cheng Seng H. | Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases |
KR100381512B1 (en) | 2000-09-21 | 2003-04-26 | 굿젠 주식회사 | Cationic lipids and use thereof |
CA2436830A1 (en) * | 2000-11-06 | 2002-06-20 | Asilomar Pharmaceuticals, Inc. | Intracellular delivery of charged therapeutic moieties to nerve cells by means of targeting proteins |
CA2449873A1 (en) * | 2001-06-07 | 2002-12-12 | Celator Technologies, Inc. | Cell penetrating therapeutic agents |
EP3100719A3 (en) | 2002-05-15 | 2017-02-22 | California Pacific Medical Center | Delivery of nucleic acid-like compounds |
AU2003278776A1 (en) * | 2002-09-10 | 2004-04-30 | Vical Incorporated | Codon-optimized polynucleotide-based vaccines against bacillus anthracis infection |
EP1581201A4 (en) | 2002-12-23 | 2011-03-30 | Vical Inc | Method for producing sterile polynucleotide based medicaments |
AU2003293195A1 (en) * | 2002-12-23 | 2004-07-29 | Vical Incorporated | Method for freeze-drying nucleic acid/block copolymer/cationic surfactant complexes |
US8080642B2 (en) * | 2003-05-16 | 2011-12-20 | Vical Incorporated | Severe acute respiratory syndrome DNA compositions and methods of use |
ES2347340T3 (en) | 2004-09-13 | 2010-10-28 | Genzyme Corporation | MULTIMERICAL CONSTRUCTIONS. |
US20060134221A1 (en) * | 2004-12-03 | 2006-06-22 | Vical Incorporated | Methods for producing block copolymer/amphiphilic particles |
WO2008106646A2 (en) * | 2007-03-01 | 2008-09-04 | Introgen Therapeutics, Inc | Methods and formulations for topical gene therapy |
JP5902617B2 (en) * | 2010-04-28 | 2016-04-13 | 協和発酵キリン株式会社 | Cationic lipid |
EP2567951B1 (en) * | 2010-04-28 | 2018-09-19 | Kyowa Hakko Kirin Co., Ltd. | Cationic lipid |
JP2013095755A (en) * | 2011-11-02 | 2013-05-20 | Kyowa Hakko Kirin Co Ltd | Cationic lipid |
WO2013185116A1 (en) * | 2012-06-08 | 2013-12-12 | Payne Joseph E | Lipids for therapeutic agent delivery formulations |
CN107427531A (en) | 2015-03-24 | 2017-12-01 | 协和发酵麒麟株式会社 | Lipid nanoparticle containing nucleic acid |
WO2020018700A1 (en) | 2018-07-18 | 2020-01-23 | Manzanita Pharmaceuticals, Inc. | Conjugates for delivering an anti-cancer agent to nerve cells, methods of use and methods of making thereof |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2368208A (en) * | 1940-12-16 | 1945-01-30 | Emulsol Corp | Chemical compounds and method of preparing same |
US3265719A (en) * | 1959-12-28 | 1966-08-09 | American Cyanamid Co | Betaines |
DE2651898A1 (en) * | 1976-11-13 | 1978-05-18 | Hoechst Ag | SOFTENING DETERGENT |
US5049386A (en) * | 1985-01-07 | 1991-09-17 | Syntex (U.S.A.) Inc. | N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
DE3618517A1 (en) * | 1985-06-04 | 1986-12-04 | Lion Corp., Tokio/Tokyo | Emulsifying agent for emulsion polymerisation |
US5068431A (en) * | 1987-08-31 | 1991-11-26 | Witco Corporation | Methods of making new surface active compounds |
US4864060A (en) * | 1987-08-31 | 1989-09-05 | Witco Corporation | Surface active compounds, methods for making same and uses thereof |
CA2001401A1 (en) * | 1988-10-25 | 1990-04-25 | Claude Piantadosi | Quaternary amine containing ether or ester lipid derivatives and therapeutic compositions |
JPH03181597A (en) * | 1989-12-12 | 1991-08-07 | Bridgestone Corp | Electric viscous fluid |
US5279833A (en) * | 1990-04-04 | 1994-01-18 | Yale University | Liposomal transfection of nucleic acids into animal cells |
US5264618A (en) * | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
US5334761A (en) * | 1992-08-28 | 1994-08-02 | Life Technologies, Inc. | Cationic lipids |
DE4241983C1 (en) * | 1992-12-12 | 1994-03-24 | Messer Griesheim Gmbh | Shielding gas for the arc welding of aluminum |
US5364324A (en) * | 1992-12-14 | 1994-11-15 | Boettiger Jr Walter W | Exercise device |
US5753613A (en) * | 1994-09-30 | 1998-05-19 | Inex Pharmaceuticals Corporation | Compositions for the introduction of polyanionic materials into cells |
-
1996
- 1996-04-09 US US08/629,965 patent/US5994317A/en not_active Expired - Lifetime
-
1997
- 1997-04-08 DE DE69707870T patent/DE69707870T2/en not_active Expired - Lifetime
- 1997-04-08 DK DK97920200T patent/DK0902780T3/en active
- 1997-04-08 WO PCT/US1997/005757 patent/WO1997037966A1/en active IP Right Grant
- 1997-04-08 CA CA002251169A patent/CA2251169C/en not_active Expired - Fee Related
- 1997-04-08 EP EP97920200A patent/EP0902780B1/en not_active Expired - Lifetime
- 1997-04-08 AT AT97920200T patent/ATE207874T1/en not_active IP Right Cessation
- 1997-04-08 ES ES97920200T patent/ES2166540T3/en not_active Expired - Lifetime
- 1997-04-08 JP JP53642397A patent/JP4031045B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1997037966A1 (en) | 1997-10-16 |
DE69707870D1 (en) | 2001-12-06 |
ES2166540T3 (en) | 2002-04-16 |
CA2251169C (en) | 2006-12-19 |
EP0902780A1 (en) | 1999-03-24 |
DK0902780T3 (en) | 2002-02-11 |
ATE207874T1 (en) | 2001-11-15 |
EP0902780B1 (en) | 2001-10-31 |
JP4031045B2 (en) | 2008-01-09 |
JP2000508642A (en) | 2000-07-11 |
US5994317A (en) | 1999-11-30 |
DE69707870T2 (en) | 2002-07-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20160408 |