CA2251852A1 - Means and methods for the treatment of neurological disorders - Google Patents

Means and methods for the treatment of neurological disorders

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Publication number
CA2251852A1
CA2251852A1 CA002251852A CA2251852A CA2251852A1 CA 2251852 A1 CA2251852 A1 CA 2251852A1 CA 002251852 A CA002251852 A CA 002251852A CA 2251852 A CA2251852 A CA 2251852A CA 2251852 A1 CA2251852 A1 CA 2251852A1
Authority
CA
Canada
Prior art keywords
control module
patient
electronic circuitry
electrodes
electrode
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002251852A
Other languages
French (fr)
Other versions
CA2251852C (en
Inventor
Robert E. Fischell
David R. Fischell
Adrian R. M. Upton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NeuroPace Inc
Original Assignee
NeuroPace Inc
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Filing date
Publication date
Application filed by NeuroPace Inc filed Critical NeuroPace Inc
Publication of CA2251852A1 publication Critical patent/CA2251852A1/en
Application granted granted Critical
Publication of CA2251852C publication Critical patent/CA2251852C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/369—Electroencephalography [EEG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4076—Diagnosing or monitoring particular conditions of the nervous system
    • A61B5/4094—Diagnosing or monitoring seizure diseases, e.g. epilepsy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6814—Head
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/40—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36025—External stimulators, e.g. with patch electrodes for treating a mental or cerebral condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36082—Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/37211—Means for communicating with stimulators

Abstract

Disclosed is a multiple electrode, closed-loop, responsive system for the treatment of certain neurological diseases such as epilepsy, migraine headaches and Parkinson's disease. Brain electrodes would be placed in close proximity to the brain or deep within brain tissue. When a neurological event such as the onset of an epileptic seizure occurs, EEG signals from the electrodes are processed by signal conditioning means in a control module that can be placed beneath the patient's scalp, within the patient's chest, or situated externally on the patient.
Neurological event detection means in the control module will then cause a response to be generated for stopping the neurological event. The response could be an electrical signal to brain electrodes or to electrodes located remotely in the patient's body. The response could also be the release of medication or the application of a sensory input such as sound, light or mechanical vibration or electrical stimulation of the skin. The response to the neurological event can originate from devices either internal or external to the patient. The system also has the capability for multi-channel recording of EEG related signals that occur both before and after the detection of a neurological event. Programmability of many different operating parameters of the system by means of external equipment provides adaptability for treating patients who manifest different symptoms and who respond differently to the response generated by the system.

Claims (228)

1. A system for the treatment of neurological disorders of a human patient, the system comprising:

at least two electrodes located in close proximity to the patient's brain or within the brain;

a control module implanted beneath the patient's scalp the control module including electronic circuitry;

electrical conducting means which provide electrical connections between the electrodes and the electronic circuitry of the control module; and external equipment located external to the patient, the external equipment being adapted to provide two-way communication between the external equipment and the control module implanted beneath the scalp.
2. The system of claim 1 wherein there are exactly two electrodes.
3. The system of claim 2 wherein the control module has an outer surface and at least part of that outer surface is electrically conducting and is one of the electrodes, and at least one of the other electrodes is an active electrode connected to the control module by the electrical conducting means.
4. The system of claim 1 wherein there are at least three electrodes.
5. The system of claim 4 wherein the control module has an outer surface and at least part of that outer surface is electrically conducting and at least one of the other electrodes is an active electrode connected to the control module by the electrical conducting means.
6. The system of claim 1 wherein there are at least four electrodes.
7. The system of claim 6 wherein the control module has an outer surface and at least part of that outer surface is electrically conducting and is one of the electrodes, and at least one of the other electrodes is an active electrode connected to the control module by the electrical conducting means.
8. The system of claim 1 wherein the electrical conducting means includes at least one insulated conducting wire, the wire having a proximal end and a distal end, the proximal end of each wire being joined to the control module and the distal end of each wire being joined to an electrode, the path of the wire from the control module to the electrode including passage between the patient's scalp and cranium.
9. The system of claim 1 wherein the conducting means is an insulated wire, the path of the wire from the control module to the electrode including passage through a hole in the patient's cranium.
10. The system of claim 1 wherein the electrical conducting means includes at least one insulated conducting wire, the wire having a proximal end and a distal end, the proximal end of each wire being joined to the control module and the distal end of each wire being joined to an electrode, the path of the wire from the control module to the electrode including passage between the dura mater of the patient's brain and the patient's cranium.
11. The system of claim 1 wherein at least one electrode is a deep electrode which is placed within the brain.
12. The system of claim 11 wherein the deep electrode is placed within the hippocampus.
13. The system of claim 11 wherein the deep electrode is placed within the thalamus.
14. The system of claim 1 wherein at least one electrode is a surface electrode, the surface electrode being placed on the dura mater of the patient's brain.
15. The system of claim 1 wherein at least one electrode is a sub-scalp electrode, the sub-scalp electrode being placed between the patient's scalp and cranium.
16. The system of claim 1 wherein at least one electrode is a brain surface electrode, the brain surface electrode being placed between the patient's brain and the arachnoid.
17. The system of claim 1 wherein at least one electrode is an arachnoid electrode, the arachnoid electrode being placed between the patient's arachnoid and dura mater.
18. The system of claim 1 wherein at least one electrode is a scalp electrode, the scalp electrode being placed on the outer surface of the patient's scalp.
19. The system of claim 1 wherein at least one electrode is a dura mater surface electrode and at least one other electrode is a deep brain electrode.
20. The system of claim 8 wherein at least one electrode is placed within the posterior half of the patient's cranium, the at least one electrode being at the distal end of the insulated conducting wire which has a first length placed between the patient's scalp and cranium, and a second length being placed between the underside of the cranium and the dura mater, the first length being longer than the second length.
21. The system of claim 8 wherein at least one electrode is placed within the anterior half of the patient's cranium, the at least one electrode being at the distal end of the insulated conducting wire which has a first length placed between the patient's scalp and cranium, and a second length being placed between the underside of the cranium and the dura mater, the first length being shorter than the second length.
22. The system of claim 1 wherein at least one electrode is placed within 2 centimeters of the center of an epileptic focus of an epileptic patient.
23. The system of claim 1 wherein the control module includes an event detection sub-system that is adapted to identify the occurrence of a neurological event by processing of at least one EEG signal being detected from at least one electrode.
24. The system of claim 23 wherein the event detection sub-system includes a signal conditioning means and an event detection means, the signal conditioning means having an input and an output, the event detection means having an input and an output, the input of the signal conditioning means being at least one EEG signal from at least one electrode, the output of the signal conditioning means being at least one of the inputs of the event detection means.
25. The system of claim 24 wherein the signal conditioning means includes one or more signal conditioning steps.
26. The system of claim 25 wherein at least one of the signal conditioning steps is amplification.
27. The system of claim 25 wherein at least one of the signal conditioning steps is automatic gain control.
28. The system of claim 25 wherein at least one of the signal conditioning steps is signal squaring.
29. The system of claim 25 wherein at least one of the signal conditioning steps is signal rectification.
30. The system of claim 25 wherein at least one of the signal conditioning steps is summing of two or more signals.
31. The system of claim 25 wherein at least one of the signal conditioning steps is subtracting one signal from another.
32. The system of claim 25 wherein at least one of the signal conditioning steps is low pass filtering.
33. The system of claim 25 wherein at least one of the signal conditioning steps is high pass filtering.
34. The system of claim 25 wherein at least one of the signal conditioning steps is band pass filtering.
35. The system of claim 25 wherein at least one of the signal conditioning steps is frequency transformation.
36. The system of claim 25 wherein at least one of the signal conditioning steps is analog-to-digital conversion.
37. The system of claim 25 wherein at least one of the signal conditioning steps is digital-to-analog conversion.
38. The system of claim 24 wherein the signal conditioning means utilizes the information of the different propagation times from the focus of a neurological event to the location of each electrode to improve the probability for reliable detection of a neurological event.
39. The system of claim 24 wherein the signal conditioning means includes digital signal processing.
40. The system of claim 1 wherein two electrodes are placed at two different locations, each of the locations being such that the propagation time of the EEG
signal from the focus of a neurological event to each one of the two electrodes is the same.
41. The system of claim 24 wherein two electrodes are placed at two different locations, each of the locations being such that the propagation time of the EEG
signal from the focus of a neurological event to each of the two electrodes is different, the signal conditioning means being adapted to provide an appropriate time delay for each EEG signal from each electrode in order to produce a set of time synchronized EEG signals.
42. The system of claim 24 wherein the event detection sub-system is programmable.
43. The system of claim 42 wherein the programmability includes the selection of which one or more of the EEG signals will be processed by the signal conditioning means.
44. The system of claim 42 wherein the signal conditioning means includes one or more signal conditioning steps, the implementation of a particular set of one or more signal conditioning steps being programmable.
45. The system of claim 41 wherein the appropriate time delay for each EEG signal for each of the two electrodes is programmable.
46. The system of claim 45 wherein the programmable time delays are set by a command transmitted from the external equipment to the event detection sub-system of the control module by means of the two-way communication.
47. The system of claim 42 wherein the programmable event detection sub-system includes the capability for self-adaptation.
48. The system of claim 45 wherein the programmable time delays are self-adaptive within the event detection sub-system.
49. The system of claim 24 wherein the event detection means includes one or more event detection steps.
50. The system of claim 49 wherein at least one of the event detection steps is a comparison of the output of the signal conditioning means with an event detection threshold.
51. The system of claim 50 wherein the level of the event detection threshold is programmable.
52. The system of claim 49 wherein at least one of the event detection steps is an event density counter/detector which determines if there is a neurological event by comparing the number of counts in a set period of time with a preset number of counts in that said period of time.
53. The system of claim 52 wherein the set period of time is programmable.
54. The system of claim 52 wherein the preset number is programmable.
55. The system of claim 52 wherein the set period of time is between 0.5 and 100 seconds.
56. The system of claim 24 wherein the operation of the signal conditioning means and the event detection means predispose the event detection sub-system to identify a real event while allowing an increase in the number of false identification of events that are not real events.
57. The system of claim 56 wherein the ratio of the number of false identification of events to number of real events detected lies between 1/2 and 5.
58. The system of claim 1 wherein the system for treatment of neurological disorders includes means for stopping a neurological event.
59. The system of claim 58 wherein the means for stopping a neurological event is the application of at least one electrical signal applied to at least one electrode.
60. The system of claim 59 wherein two or more signals are applied to two or more electrodes.
61. The system of claim 60 wherein the two or more signals applied to the two or more electrodes are identical.
62. The system of claim 60 wherein the two or more signals applied to the two or more electrodes are different.
63. The system of claim 62 wherein the difference between the signals applied includes different values for the parameters of amplitude, frequency, phase or any combination of one, two or three of these parameters.
64. The system of claim 63 wherein the means for stopping a neurological event is adapted to provide all signals being received at a neurological focus with essentially identical phase.
65. The system of claim 58 wherein the means for stopping a neurological event includes the electrical shorting together of at least two of the electrodes.
66. The system of claim 65 wherein at least one of the electrodes is located within 2 centimeters of the center of a focus of a neurological event.
67. The system of claim 66 wherein the control module has an outer surface and at least part of that outer surface is electrically conducting and that part of that outer surface is one of the electrodes that is electrically shorted together with at least one other electrode.
68. The system of claim 58 wherein the initiation of the means for stopping a neurological event originates from the electronic circuitry in the control module thus providing an automatic response to the detection of a neurological event.
69. The system of claim 58 wherein the initiation of the means for stopping a neurological event originates from the external equipment thus providing a manual response to the detection of a neurological event.
70. The system of claim 69 wherein the external equipment used to initiate the means for stopping of a neurological event is a physician's workstation.
71. The system of claim 69 wherein the external equipment used to initiate the means for stopping of a neurological event is a patient's initiating device.
72. The system of claim 59 wherein the electrical signal has a biphasic waveform.
73. The system of claim 59 wherein the electrical signal has an rms voltage between 1 millivolt and 10 volts.
74. The system of claim 59 wherein the electrical signal has a frequency between 0.1 and 1000 Hz.
75. The system of claim 59 wherein the electrical signal is a d-c voltage.
76. The system of claim 59 wherein the time period for applying the electrical signal is between 1 millisecond and 30 minutes.
77. The system of claim 1 wherein the electronic circuitry of the control module includes data recording means.
78. The system of claim 77 wherein the data recording means includes the ability to record one or more EEG signals.
79. The system of claim 77 wherein the data recording means includes the ability to simultaneously record two or more EEG signals.
80. The system of claim 77 wherein the data recording means includes analog-to-digital conversion and a digital memory, the digital memory being capable of storing data received or processed by the electronic circuitry of the control module.
81. The system of claim 80 wherein the digital memory is adapted to record data for a time period before the detection of a neurological event.
82. The system of claim 80 wherein the digital memory is adapted to record data for a time period after the detection of a neurological event.
83. The system of claim 80 wherein the digital memory is adapted to record data for a first time period before the detection of a neurological event and a second time period after the detection of the neurological event.
84. The system of claim 81 wherein the time period is between 0.1 and 30 minutes.
85. The system of claim 82 wherein the time period is between 0.1 and 30 minutes.
86. The system of claim 83 wherein the first time period is between 0.1 and 30 minutes and the second time period is between 0.1 and 30 minutes.
87. The system of claim 80 wherein the data recording means includes the capability of storing in the digital memory data pertaining to the frequency spectrum of at least one EEG signal originating from at least one electrode.
88. The system of claim 80 wherein the data recording means includes the capability of storing within the digital memory data originating from a specific set of electrodes which set of electrodes is less than the total number of electrodes located in close proximity to the brain or within the brain.
89. The system of claim 80 wherein the data recording means includes the capability of storing within the digital memory the number of neurological events detected over a specific time period.
90. The system of claim 80 wherein the data recording means includes the capability of storing within the digital memory a date and time of occurrence for each neurological event detected over a specific time period.
91. The system of claim 80 including means for stopping a neurological event, the data recording means including the capability of storing within the digital memory the number, time and date of each activation of the means for stopping a neurological event occurring over a specific time period.
92. The system of claim 1 wherein the electronic circuitry includes a real time clock.
93. The system of claim 92 wherein the real time clock is settable by a command from the external equipment.
94. The system of claim 1 wherein the two-way communication from the control module to the external equipment is by electromagnetic waves.
95. The system of claim 94 wherein the electromagnetic waves are in the radio frequency range.
96. The system of claim 94 wherein the electromagnetic waves are infra-red radiation.
97. The system of claim 1 wherein the two-way communication from the control module to the external equipment is by ultrasonic signals.
98. The system of claim 1 wherein the two-way communication from the control module to the electronic equipment is via electrical conducting means that passes through the patient's scalp.
99. The system of claim 1 wherein the electronic circuitry contains an alarming means, the alarming means being capable of signaling the patient.
100. The system of claim 99 wherein the alarming means signals the patient by mechanical vibrations.
101. The system of claim 99 wherein the alarming means signals the patient by an electrical tickle.
102. The system of claim 1 wherein the control module includes an electric power source for providing electric power to the electronic circuitry.
103. The system of claim 102 wherein the electric power source is a primary battery.
104. The system of claim 102 wherein the electric power source is a rechargeable battery.
105. The system of claim 104 wherein the rechargeable battery is recharged by means of a flat wire coil which receives energy from the external equipment by means of magnetic induction which imposes an alternating magnetic field on the flat wire coil.
106. The system of claim 1 wherein the electric power to operate the electronic circuitry in the control module is provided by means of a flat wire coil which receives energy from the external equipment by means of magnetic induction which imposes an alternating magnetic field on the flat wire coil.
107. The system of claim 1 wherein the electric power for the electronic circuitry of the control module is provided from the external equipment by an electrical conducting means that passes through the patient's scalp.
108. The system of claim 102 wherein the mechanical design of the control module is adapted to allow replacement of the power source without removing the entire control module from its implantation site beneath the patient's scalp.
109. The system of claim 1 wherein the mechanical design of the control module is adapted to allow replacement of the electronic circuitry without removing the entire control module from its implantation site beneath the patient's scalp.
110. The system of claim 58 further comprising a programmable implantable drug delivery system adapted for stopping a neurological event by the infusion of medication into the patient's body.
111. The system of claim 110 wherein the infusion of medication is directed into the cerebrospinal fluid.
112. The system of claim 110 wherein the infusion of medication is directed into the bloodstream.
113. The system of claim 110 wherein the medication is infused directly into brain tissue.
114. The system of claim 110 wherein the means for stopping a neurological event includes both the infusion of medication into the patient's body and the use of at least one electrical signal applied to at least one electrode.
115. The system of claim 1 wherein the control module is implanted within the cranium at a location where cranium bone has been removed.
116. The system of claim 1 wherein the control module is implanted between the patient's cranium and scalp.
117. The system of claim 1 wherein the external equipment includes an external data interface and a physician's workstation, the external data interface providing the two-way communication with the control module and further providing data communication with the physician's workstation.
118. The system of claim 117 wherein the data communication between the external data interface and the physician's workstation is either by a multiplicity of wires or a pair of modems.
119. The system of claim 117 wherein the external data interface includes a cap to be worn by the patient.
120. The system of claim 119 wherein the cap has an emitting and receiving device that is adapted to provide the two-way communication link between the external equipment and the control module implanted beneath the patient's scalp.
121. The system of claim 119 wherein the cap's emitting and receiving device is adapted to provide electrical power to the control module implanted beneath the patient's scalp.
122. The system of claim 119 wherein the control module includes a rechargeable battery and the cap's emitting and receiving device is adapted to provide electrical power to recharge the rechargeable battery.
123. A system for the treatment of neurological disorders of a human patient, the system comprising:

at least three electrodes located in close proximity to the patient's brain or within the brain;

a control module implanted within the patient's body, the control module including electronic circuitry;

electrical conducting means which provide electrical connections between the electrodes and the electronic circuitry of the control module; and external equipment located external to the patient, the external equipment being adapted to provide two-way communication between the external equipment and the control module implanted within the patient's body.
124. The system of claim 123 wherein the control module is placed within the patient's chest.
125. A system for the treatment of neurological disorders of a human patient, the system comprising:

at least two electrodes located in close proximity to the patient's brain or within the brain, at least one electrode being a surface electrode, the surface electrode being placed on the dura mater of the patient's brain, and at least one other electrode being a deep brain electrode, the deep brain electrode being placed within the -patient's brain.

a control module implanted within the patient's body, the control module including electronic circuitry;

electrical conducting means which provide electrical connections between the electrodes and the electronic circuitry of the control module; and external equipment located external to the patient, the external equipment being adapted to provide two-way communication between the external equipment and the control module implanted within the patient's body.
126. The system of claim 125 wherein the control module is placed within the patient's chest.
127. A system for the treatment of an epileptic patient, the system comprising:

at least two electrodes located in close proximity to the patient's brain or within the brain, at least one electrode being placed within two centimeters of the center of an epileptic focus of the epileptic patient.

a control module implanted within the patient's body, the control module including electronic circuitry;

electrical conducting means which provide electrical connections between the electrodes and the electronic circuitry of the control module; and external equipment located external to the patient, the external equipment being adapted to provide two-way communication between the external equipment and the control module implanted within the patient's body.
128. The system of claim 127 wherein the control module is placed within the patient's chest.
129. A system for the treatment of neurological disorders of a human patient, the system comprising:

at least two electrodes located in close proximity to the patient's brain or within the brain;

a control module implanted within the patient's body, the control module including electronic circuitry, the electronic circuitry including an event detection sub-system that is adapted to identify the occurrence of a neurological event by processing of at least one EEG signal being detected from at least one electrode;

electrical conducting means which provide electrical connections between the electrodes and the electronic circuitry of the control module; and external equipment located external to the patient, the external equipment being adapted to provide two-way communication between the external equipment and the control module implanted within the patient's body.
130. The system of claim 129 wherein the event detection sub-system includes a signal conditioning means and an event detection means, the signal conditioning means having an input and an output, the event detection means having an input and an output, the input of the signal conditioning means being at least one EEG signal from at least one electrode, the output of the signal conditioning means being the at least one of the inputs of the event detection means.
131. The system of claim 129 wherein the control module is placed within the patient's chest.
132. A system for the treatment of neurological disorders of a human patient, the system comprising:

at least two electrodes located in close proximity to the patient's brain or within the brain;

a control module implanted within the patient's body, the control module including electronic circuitry;

electrical conducting means which provide electrical connections between the electrodes and the electronic circuitry of the control module, the electronic circuitry of the control module, the electrical conducting means and the at least two electrodes cooperating to provide a means for stopping a neurological event; and external equipment located external to the patient, the external equipment being adapted to provide two-way communication between the external equipment and the control module implanted within the patient's body.
133. The system of claim 132 wherein the means for stopping a neurological event includes the electrical shorting together of at least two of the electrodes.
134. The system of claim 132 wherein the initiation of the means for stopping a neurological event originates from the electronic circuitry in the control module thus providing an automatic response to the detection of a neurological event.
135. The system of claim 132 wherein the initiation of the means for stopping a neurological event originates from the external equipment thus providing a manual response to the detection of a neurological event.
136. The system of claim 135 wherein the external equipment used to initiate the means for stopping of a neurological event is a patient's initiating device thus providing a manual response to the detection of a neurological event.
137. The system of claim 132 wherein the control module is placed within the patient's chest.
138. A system for the treatment of neurological disorders of a human patient, the system comprising:

at least two electrodes located in close proximity to the patient's brain or within the brain;

a control module implanted within the patient's body, the control module including electronic circuitry, the control module having a structure consisting of three major parts, a first part being a thin-walled, generally cylindrical shell that is closed by a thin-walled structure at its bottom and open at its top, a second part being an electronics module containing the electronic circuitry, and a third part being a battery, electrical conducting means which provide electrical connections between the electrodes and the electronic circuitry of the control module; and external equipment located external to the patient, the external equipment being adapted to provide two-way communication between the external equipment and the control module implanted within the patient's body.
139. The system of claim 138 wherein the control module is placed within the patient's chest.
140. A system for the treatment of neurological disorders of a human patient, the system comprising:

at least two electrodes located in close proximity to the patient's brain or within the brain;

a control module implanted within the patient's body, the control module including electronic circuitry, the electronic circuitry of the control module including a data recording means;

electrical conducting means which provide electrical connections between the electrodes and the electronic circuitry of the control module; and external equipment located external to the patient, the external equipment being adapted to provide two-way communication between the external equipment and the control module implanted within the patient's body.
141. The system of claim 140 wherein the data recording means includes the ability to record one or more EEG signals.
142. The system of claim 140 wherein the data recording means includes the ability to simultaneously record two or more EEG signals.
143. The system of claim 140 wherein the data recording means includes analog-to-digital conversion and a digital memory, the digital memory being capable of storing data received or processed by the electronic circuitry of the control module.
144. The system of claim 143 wherein the digital memory is adapted to record data for a time period before the detection of a neurological event.
145. The system of claim 143 wherein the digital memory is adapted to record data for a time period after the detection of a neurological event.
146. The system of claim 143 wherein the digital memory is adapted to record data for a first time period before the detection of a neurological event and a second time period after the detection of the neurological event.
147. The system of claim 144 wherein the time period is between 0.1 and 30 minutes.
148. The system of claim 145 wherein the time period is between 0.1 and 30 minutes.
149. The system of claim 146 wherein the first time period is between 0.1 and 30 minutes and the second time period is between 0.1 and 30 minutes.
150. The system of claim 143 wherein the data recording means includes the capability of storing in the digital memory data pertaining to the frequency spectrum of at least one EEG signal originating from at least one electrode.
151. The system of claim 143 wherein the data recording means includes the capability of storing within the digital memory data originating from a specific set of electrodes which set of electrodes is less than the total number of electrodes located in close proximity to the brain or within the brain.
152. The system of claim 143 wherein the data recording means includes the capability of storing within the digital memory the number of neurological events detected over a specific time period.
153. The system of claim 143 wherein the data recording means includes the capability of storing within the digital memory the time of occurrence of each neurological event detected over a specific time period.
154. The system of claim 143 including means for stopping a neurological event, the data recording means including the capability for storing within the digital memory the number, time and date of each activation of the means for stopping a neurological event occurring over a specific time period.
155. The system of claim 140 wherein the electronic circuitry includes a real time clock.
156. The system of claim 155 wherein the real time clock is settable by a command from the external equipment.
157. The system of claim 140 wherein the electronic circuitry of the control module generates electrical signals related to the EEG signals received from each electrode, the data recording means being adapted to record and hold any one or more of the electrical signals related to the EEG signals which are generated within the electronic circuitry of the control module.
158. The system of claim 157 wherein the external equipment is adapted to command the data recording means to record and hold any one or more of the electrical signals related to the EEG signals generated within the electronic circuitry of the control module.
159. The system of claim 158 wherein the external equipment that commands the data recording means to record and hold any one or more of the electrical signals generated within the electronic circuitry of the control module is a patient's initiating device.
160. The system of claim 158 wherein the external equipment that commands the data recording means to record and hold any one or more of the electrical signals generated within the electronic circuitry of the control module is a physician's workstation.
161. The system of claim 140 wherein the control module is placed within the patient's chest.
162. A system for the treatment of neurological disorders of a human patient, the system comprising:

at least two electrodes located in close proximity to the patient's brain or within the brain;

a control module implanted within the patient's body, the control module including electronic circuitry;

a programmable implantable drug delivery system adapted to infuse medication into the patient's body;

electrical conducting means which provide electrical connections between the electrodes and the electronic circuitry of the control module, the electronic circuitry of the control module, the electrical conducting means, the at least two electrodes and the programmable implantable drug delivery system cooperating to provide a means for stopping a neurological event; and external equipment located external to the patient, the external equipment being adapted to provide two-way communication between the external equipment and the control module implanted within the patient's body.
163. The system of claim 162 wherein the infusion of medication is directed into the cerebrospinal fluid.
164. The system of claim 162 wherein the infusion of medication is directed into the bloodstream.
165. The system of claim 162 wherein the means for stopping a neurological event includes both the infusion of medication into the patient's body and the use of at least one electrical signal applied to at least one electrode.
166. A system for the treatment of neurological disorders of a human patient, the system comprising:

at least two electrodes located in close proximity to the patient's brain or within the brain;

a control module implanted under the patient's scalp, the control module including electronic circuitry;

a sensor/actuator device implanted within the patient's body at a location remote from the control module, the sensor/actuator device having electronic circuitry, the electronic circuitry of the sensor/actuator device being adapted to communicate with the electronic circuitry of the control module, by signaling means sent through the patient's body;

electrical conducting means which provide electrical connections between the electrodes and the electronic circuitry of the control module; and external equipment located external to the patient, the external equipment being adapted to provide two-way communication between the external equipment and the control module implanted within the patient's body.
167. The system of claim 166 wherein the signaling means is by electrical conduction of an electrical signal through the patient's body.
168. The system of claim 166 wherein the signaling means is by electromagnetic waves sent through the patient's body.
169. The system of claim 169 wherein the electromagnetic waves are in the radio frequency range.
170. The system of claim 166 wherein the signaling means is by mechanical vibrations sent through the patient's body.
171. The system of claim 166 wherein the remote sensor/actuator device includes medication infusion means.
172. The system of claim 166 wherein the remote sensor/actuator device includes electrical stimulation means, the electrical stimulation means including the following; (1) at least part of the electronic circuitry of the remote sensor/actuator device; (2) two or more electrodes; and (3) conducting means from each electrode to the electronic circuitry of the remote sensor/actuator device.
173. The system of claim 166 wherein the remote sensor/actuator device includes electrical sensing means, the electrical sensing means including the following;
(1) at least part of the electronic circuitry of the remote sensor/actuator device;
(2) two or more electrodes; and (3) conducting means from each electrode to the electronic circuitry of the remote sensor/actuator device.
174. The system of claim 166 wherein the electronic circuitry of the remote sensor/actuator device includes data recording means, the data recording means being adapted to record electrical signals processed within the electronic circuitry of the remote sensor/actuator device.
175. The system of claim 166 wherein the control module includes electrical stimulation means, the electrical stimulation means including at least part of the electronic circuitry of the control module, and also including two or more electrodes and the conducting means from each electrode to the electronic circuitry of the control module, the electrical stimulation means being adapted to apply an electrical stimulation signal to one or more of the electrodes located in close proximity to the patient's brain or within the brain.
176. The system of claim 166 wherein the control module includes electrical sensing means, the electrical sensing means including at least part of the electronic circuitry of the control module, and also including two or more electrodes and the conducting means from each electrode to the electronic circuitry of the control module.
177. The system of claim 166 wherein the electronic circuitry of the control module includes data recording means, the data recording means being adapted to record electrical signals processed within the electronic circuitry of the control module.
178. The system of claim 171 wherein the control module can initiate a command to the remote sensor/actuator device by the signaling means to cause the remote sensor/actuator device's medication infusion means to release medication into the patient's body.
179. The system of claim 172 wherein the control module can initiate a command to the remote sensor/actuator device by the signaling means to cause the remote sensor/actuator device's electrical stimulation means to apply an electrical stimulation signal to one or more of the electrodes placed within the patient's body.
180. The system of claim 174 wherein the control module can initiate a command to the remote sensor/actuator device by the signaling means to cause the remote sensor/actuator device's recording means to record data processed within the electronic circuitry of the remote sensor/actuator device.
181. The system of claim 177 wherein the remote sensor/actuator device can initiate a command to the control module by the signaling means to cause the control module's recording means to record data processed within the electronic circuitry of the control module.
182. The system of claim 175 wherein the remote sensor/actuator device can initiate a command to the control module by the signaling means to cause the control module's electrical stimulation means to apply an electrical stimulation signal to one or more of the electrodes placed in close proximity to the patient's brain or within the brain.
183. A system for the treatment of neurological disorders of a human patient, the system comprising:
at least two electrodes located in close proximity to the patient's brain or within the brain;

a control module located external to the patient's body, the control module including electronic circuitry;

electrical conducting means which provide electrical connections between the electrodes and the electronic circuitry of the control module, the electronic circuitry of the control module, the electrical conducting means and the at least two electrodes cooperating to provide a means for detecting a neurological event; and external equipment located external to the patient, the external equipment being adapted to provide two-way communication between the external equipment and the control module located external to the patient's body.
184. The system of claim 183 further comprising means for stopping a neurological event.
185. The system of claim 184 wherein the means for stopping a neurological event uses at least one electrical signal applied to at least one electrode.
186. The system of claim 185 wherein two or more signals are applied to two or more electrodes.
187. The system of claim 186 wherein the signals applied to the two or more electrodes are identical.
188. The system of claim 186 wherein the at least two of the signals applied to the two or more electrodes are different.
189. The system of claim 188 wherein the difference between the signals applied includes different values for the parameters of amplitude, frequency, phase or any combination of one, two or three of these parameters.
190. The system of claim 184 wherein the means for stopping a neurological event includes the electrical shorting together of at least two of the electrodes.
191. The system of claim 185 wherein at least one of the electrodes is located within two centimeters from the center of the focus of the neurological event.
192. The system of claim 184 wherein the initiation of the means for stopping a neurological event originates from the electronic circuitry in the control module.
193. The system of claim 184 wherein the initiation of the means for stopping a neurological event originates from the external equipment.
194. The system of claim 185 wherein the electrical signal has a biphasic waveform.
195. The system of claim 183 wherein at least one electrode is placed under the patient's scalp.
196. The system of claim 183 wherein at least one electrode is placed on the patient's scalp.
197. The system of claim 185 wherein the electrical signal has a frequency between 0.1 and 1000 Hz.
198. The system of claim 185 wherein the time period for applying the electrical signal is between 1 millisecond and 30 minutes.
199. The system of claim 183 wherein the electronic circuitry of the control module includes data recording means, the data recording means being adapted to record electrical signals processed within the electronic circuitry of the control module.
200. The system of claim 199 wherein the data recording means includes the ability to record one or more EEG signals.
201. The system of claim 183 wherein the control module is placed behind the patient's ear.
202. The system of claim 184 wherein the control module is adapted to emit sound, the emitted sound being the means for stopping a neurological event.
203. The system of claim 184 wherein the means for stopping a neurological event is a remote sensor/actuator device implanted within the patient's body, the sensor/actuator device having electronic circuitry, the electronic circuitry of the sensor/actuator device being adapted to communicate with the electronic circuitry of the control module by signaling means sent through the patient's body, the signaling means being adapted to allow the control module to command the remote sensor/actuator device to initiate the means for stopping a neurological event.
204. The system of claim 184 wherein the means for stopping a neurological event is a remote actuator located external to the patient's body at a location remote from the control module.
205. The system of claim 204 wherein the external remote actuator contains electronic circuitry, the electronic circuitry of the external remote actuator being adapted to communicate with the electronic circuitry of the control module by signaling means sent through the patient's body, the signaling means being adapted to allow the control module to command the external remote actuator to initiate the means for stopping a neurological event.
206. The system of claim 204 wherein the external remote actuator is adapted to allow the patient to command the remote actuator to initiate the means for stopping a neurological event.
207. The system of claim 204 wherein the external remote actuator is adapted to emit light.
208. The system of claim 204 wherein the external remote actuator is adapted to produce mechanical vibrations.
209. The system of claim 204 wherein the external remote actuator is adapted to emit sound.
210. The system of claim 204 wherein the remote actuator is adapted to deliver electrical stimulation to the skin of the patient.
211. The system of claim 207 wherein the actuator is adapted to fit onto a pair of eyeglasses.
212. The system of claim 209 wherein the actuator is adapted to fit within the patient's ear.
213. The system of claim 203 wherein the implanted remote sensor/actuator device includes medication infusion means.
214. The system of claim 203 wherein the implanted remote sensor/actuactor device includes electrical stimulation means, the electrical stimulation means including at least part of the electronic circuitry of the remote sensor/actuator device, and also including two or more electrodes and the conducting means from each electrode to the electronic circuitry of the remote sensor/actuator device.
215. A system for the treatment of neurological disorders of a human patient, the system comprising:
at least two electrodes located in close proximity to the patient's brain or within the brain;
a control module implanted within the patient's body, the control module including electronic circuitry;

electrical conducting means which provide electrical connections between the electrodes and the electronic circuitry of the control module, the electronic circuitry of the control module, the electrical conducting means and the at least two electrodes cooperating to provide a means for detecting a neurological event;
a remote actuator located external to the patient's body, the remote actuator being adapted to provide a means for stopping a neurological event, and external equipment located external to the patient, the external equipment being adapted to provide two-way communication between the external equipment and the control module located external to the patient's body.
216. The system of claim 215 wherein the electronic circuitry of the control module includes data recording means, the data recording means being adapted to record electrical signals processed within the electronic circuitry of the control module.
217. The system of claim 216 wherein the data recording means includes the ability to record one or more EEG signals.
218. The system of claim 215 wherein the external remote actuator contains electronic circuitry, the electronic circuitry of the external remote actuator being adapted to communicate with the electronic circuitry of the control module by signaling means sent through the patient's body, the signaling means being adapted to allow the control module to command the external remote actuator to initiate the means for stopping a neurological event.
219. The system of claim 215 wherein the external remote actuator is adapted to allow the patient to command the remote actuator to initiate the means for stopping a neurological event.
220. The system of claim 215 wherein the external remote actuator is adapted to emit light.
221. The system of claim 215 wherein the external remote actuator is adapted to produce mechanical vibrations.
222. The system of claim 215 wherein the external remote actuator is adapted to emit sound.
223. The system of claim 215 wherein the remote actuator is adapted to deliver electrical stimulation to the skin of the patient.
224. The system of claim 220 wherein the external remote actuator is adapted to fit onto a pair of eyeglasses.
225. The system of claim 222 wherein at least part of the external remote actuator is adapted to fit within the patient's ear.
226. A method for replacing the battery of a control module that is placed generally beneath the scalp of a human patient, the method comprising the following steps:
(a) shaving the hair on the patient's scalp at the site under which the control module is located;

(b) making an incision through the patient's scalp at the site where the hair was removed;
(c) pulling out through the incision a depleted battery that lies within the control module;
(d) placing a new battery at the general position where the used battery was removed; and (e) closing the incision made in the scalp over the site of the control module.
227. The method of claim 226 including the following additional steps:

(a) pulling out through the incision an electronics module that lies within the control module;

(b) placing a new electronics module at the general position where the removed electronics module was located.
228. A method for replacing an electronics module from within a control module that is placed generally beneath the scalp of a human patient, the method comprising the following steps:

(a) shaving the hair on the patient's scalp at the site under which the control module is located;
(b) making an incision through the patient's scalp at the site where the hair was removed;
(c) pulling out through the incision an electronics module that lies within the control module;
(d) placing a new electronics module at the general position where the removed electronics module was located; and (e) closing the incision made in the scalp over the site of the control module.
CA2251852A 1997-10-27 1998-10-26 Means and methods for the treatment of neurological disorders Expired - Lifetime CA2251852C (en)

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7676263B2 (en) 2006-06-23 2010-03-09 Neurovista Corporation Minimally invasive system for selecting patient-specific therapy parameters
US7747325B2 (en) 1998-08-05 2010-06-29 Neurovista Corporation Systems and methods for monitoring a patient's neurological disease state
US7853329B2 (en) 1998-08-05 2010-12-14 Neurovista Corporation Monitoring efficacy of neural modulation therapy
US8036736B2 (en) 2007-03-21 2011-10-11 Neuro Vista Corporation Implantable systems and methods for identifying a contra-ictal condition in a subject
US8295934B2 (en) 2006-11-14 2012-10-23 Neurovista Corporation Systems and methods of reducing artifact in neurological stimulation systems
US9622675B2 (en) 2007-01-25 2017-04-18 Cyberonics, Inc. Communication error alerting in an epilepsy monitoring system
US9643019B2 (en) 2010-02-12 2017-05-09 Cyberonics, Inc. Neurological monitoring and alerts
US9788744B2 (en) 2007-07-27 2017-10-17 Cyberonics, Inc. Systems for monitoring brain activity and patient advisory device
US9898656B2 (en) 2007-01-25 2018-02-20 Cyberonics, Inc. Systems and methods for identifying a contra-ictal condition in a subject

Families Citing this family (804)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6480743B1 (en) * 2000-04-05 2002-11-12 Neuropace, Inc. System and method for adaptive brain stimulation
US6944501B1 (en) 2000-04-05 2005-09-13 Neurospace, Inc. Neurostimulator involving stimulation strategies and process for using it
US20020169485A1 (en) 1995-10-16 2002-11-14 Neuropace, Inc. Differential neurostimulation therapy driven by physiological context
US6463328B1 (en) * 1996-02-02 2002-10-08 Michael Sasha John Adaptive brain stimulation method and system
US6695885B2 (en) 1997-02-26 2004-02-24 Alfred E. Mann Foundation For Scientific Research Method and apparatus for coupling an implantable stimulator/sensor to a prosthetic device
US7799337B2 (en) * 1997-07-21 2010-09-21 Levin Bruce H Method for directed intranasal administration of a composition
US6731976B2 (en) 1997-09-03 2004-05-04 Medtronic, Inc. Device and method to measure and communicate body parameters
US6622036B1 (en) 2000-02-09 2003-09-16 Cns Response Method for classifying and treating physiologic brain imbalances using quantitative EEG
US20030144875A1 (en) * 1997-09-06 2003-07-31 Suffin Stephen C. EEG prediction method for medication response
US6647296B2 (en) * 1997-10-27 2003-11-11 Neuropace, Inc. Implantable apparatus for treating neurological disorders
US6230049B1 (en) * 1999-08-13 2001-05-08 Neuro Pace, Inc. Integrated system for EEG monitoring and electrical stimulation with a multiplicity of electrodes
US6427086B1 (en) 1997-10-27 2002-07-30 Neuropace, Inc. Means and method for the intracranial placement of a neurostimulator
US6016449A (en) * 1997-10-27 2000-01-18 Neuropace, Inc. System for treatment of neurological disorders
US6597954B1 (en) * 1997-10-27 2003-07-22 Neuropace, Inc. System and method for controlling epileptic seizures with spatially separated detection and stimulation electrodes
US6354299B1 (en) 1997-10-27 2002-03-12 Neuropace, Inc. Implantable device for patient communication
US6351472B1 (en) * 1998-04-30 2002-02-26 Siemens Audiologische Technik Gmbh Serial bidirectional data transmission method for hearing devices by means of signals of different pulsewidths
US6018682A (en) * 1998-04-30 2000-01-25 Medtronic, Inc. Implantable seizure warning system
US7209787B2 (en) * 1998-08-05 2007-04-24 Bioneuronics Corporation Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease
US8762065B2 (en) * 1998-08-05 2014-06-24 Cyberonics, Inc. Closed-loop feedback-driven neuromodulation
US9042988B2 (en) 1998-08-05 2015-05-26 Cyberonics, Inc. Closed-loop vagus nerve stimulation
US7277758B2 (en) * 1998-08-05 2007-10-02 Neurovista Corporation Methods and systems for predicting future symptomatology in a patient suffering from a neurological or psychiatric disorder
US9375573B2 (en) * 1998-08-05 2016-06-28 Cyberonics, Inc. Systems and methods for monitoring a patient's neurological disease state
US7403820B2 (en) * 1998-08-05 2008-07-22 Neurovista Corporation Closed-loop feedback-driven neuromodulation
US7974696B1 (en) * 1998-08-05 2011-07-05 Dilorenzo Biomedical, Llc Closed-loop autonomic neuromodulation for optimal control of neurological and metabolic disease
US7324851B1 (en) * 1998-08-05 2008-01-29 Neurovista Corporation Closed-loop feedback-driven neuromodulation
US7242984B2 (en) * 1998-08-05 2007-07-10 Neurovista Corporation Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease
US7231254B2 (en) * 1998-08-05 2007-06-12 Bioneuronics Corporation Closed-loop feedback-driven neuromodulation
US9415222B2 (en) * 1998-08-05 2016-08-16 Cyberonics, Inc. Monitoring an epilepsy disease state with a supervisory module
AU5900299A (en) 1998-08-24 2000-03-14 Emory University Method and apparatus for predicting the onset of seizures based on features derived from signals indicative of brain activity
US8636648B2 (en) * 1999-03-01 2014-01-28 West View Research, Llc Endoscopic smart probe
US10973397B2 (en) 1999-03-01 2021-04-13 West View Research, Llc Computerized information collection and processing apparatus
US7914442B1 (en) 1999-03-01 2011-03-29 Gazdzinski Robert F Endoscopic smart probe and method
US8068897B1 (en) 1999-03-01 2011-11-29 Gazdzinski Robert F Endoscopic smart probe and method
US6341236B1 (en) * 1999-04-30 2002-01-22 Ivan Osorio Vagal nerve stimulation techniques for treatment of epileptic seizures
GB9910323D0 (en) * 1999-05-06 1999-06-30 Univ Ulster Cardiac defibrillation
US6539263B1 (en) * 1999-06-11 2003-03-25 Cornell Research Foundation, Inc. Feedback mechanism for deep brain stimulation
DE19928992A1 (en) * 1999-06-24 2000-12-28 Siemens Ag Evaluation of scanned signals from a dynamic system, especially for predicting epileptic fits from brain scans, comprises determining the structural dimensionality of the system dynamics
US6516227B1 (en) 1999-07-27 2003-02-04 Advanced Bionics Corporation Rechargeable spinal cord stimulator system
US7643354B2 (en) * 1999-07-30 2010-01-05 University Of Kentucky Research Foundation Neural network model for instruments that store and retrieve sequential information
WO2001009897A1 (en) * 1999-07-30 2001-02-08 University Of Kentucky Research Foundation Method for storing and retrieving sequential information
US6420105B1 (en) 1999-08-13 2002-07-16 University Of Kentucky Research Foundation Method for analyzing molecular expression or function in an intact single cell
US6284217B1 (en) * 1999-08-17 2001-09-04 Battelle Memorial Institute Method and catalyst structure for steam reforming of a hydrocarbon
DE19944649C2 (en) * 1999-09-17 2003-07-17 Martin Lauhoff Electronic pulse evaluation device for controlling electrodes for use in muscles, nerves and organs
US6304775B1 (en) * 1999-09-22 2001-10-16 Leonidas D. Iasemidis Seizure warning and prediction
US6560486B1 (en) 1999-10-12 2003-05-06 Ivan Osorio Bi-directional cerebral interface system
US7346391B1 (en) 1999-10-12 2008-03-18 Flint Hills Scientific Llc Cerebral or organ interface system
WO2001028622A2 (en) * 1999-10-19 2001-04-26 Johns Hopkins University Techniques using heat flow management, stimulation, and signal analysis to treat medical disorders
US6882881B1 (en) * 1999-10-19 2005-04-19 The Johns Hopkins University Techniques using heat flow management, stimulation, and signal analysis to treat medical disorders
US7228171B2 (en) * 1999-10-19 2007-06-05 The Johns Hopkins University Signal analysis, heat flow management, and stimulation techniques to treat medical disorders
US6876991B1 (en) 1999-11-08 2005-04-05 Collaborative Decision Platforms, Llc. System, method and computer program product for a collaborative decision platform
US6873872B2 (en) * 1999-12-07 2005-03-29 George Mason University Adaptive electric field modulation of neural systems
DE60027459T2 (en) 1999-12-07 2006-12-21 George Mason University ADAPTIVE MODULATION OF AN ELECTRIC FIELD FOR NEURAL SYSTEMS
US20010037220A1 (en) * 1999-12-21 2001-11-01 Merry Randy L. Integrated software system for implantable medical device installation and management
US20050055064A1 (en) * 2000-02-15 2005-03-10 Meadows Paul M. Open loop deep brain stimulation system for the treatment of Parkinson's Disease or other disorders
US6920359B2 (en) * 2000-02-15 2005-07-19 Advanced Bionics Corporation Deep brain stimulation system for the treatment of Parkinson's Disease or other disorders
US6609030B1 (en) * 2000-02-24 2003-08-19 Electrocore Techniques, Llc Method of treating psychiatric diseases by neuromodulation within the dorsomedial thalamus
US6582441B1 (en) 2000-02-24 2003-06-24 Advanced Bionics Corporation Surgical insertion tool
US6389315B1 (en) 2000-02-25 2002-05-14 Medtronic, Inc. Implantable medical device incorporating self-timed logic
US6473639B1 (en) 2000-03-02 2002-10-29 Neuropace, Inc. Neurological event detection procedure using processed display channel based algorithms and devices incorporating these procedures
US6466822B1 (en) * 2000-04-05 2002-10-15 Neuropace, Inc. Multimodal neurostimulator and process of using it
DE10018518A1 (en) * 2000-04-13 2001-10-25 Walter Paulus Method of inducing changes in stimulation of the brain of a living being
US6353754B1 (en) * 2000-04-24 2002-03-05 Neuropace, Inc. System for the creation of patient specific templates for epileptiform activity detection
US7117033B2 (en) * 2000-05-08 2006-10-03 Brainsgate, Ltd. Stimulation for acute conditions
WO2001085094A2 (en) * 2000-05-08 2001-11-15 Brainsgate Ltd. Method and apparatus for stimulating the sphenopalatine ganglion to modify properties of the bbb and cerebral blood flow
US7146209B2 (en) * 2000-05-08 2006-12-05 Brainsgate, Ltd. Stimulation for treating eye pathologies
US7640062B2 (en) 2000-05-08 2009-12-29 Brainsgate Ltd. Methods and systems for management of alzheimer's disease
US6704603B1 (en) 2000-05-16 2004-03-09 Lockheed Martin Corporation Adaptive stimulator for relief of symptoms of neurological disorders
WO2001097906A2 (en) 2000-06-20 2001-12-27 Advanced Bionics Corporation Apparatus for treatment of mood and/or anxiety disorders by electrical brain stimulation and/or drug infusion
US8046076B2 (en) 2000-06-20 2011-10-25 Boston Scientific Neuromodulation Corporation Treatment of mood and/or anxiety disorders by electrical brain stimulation and/or drug infusion
US7672730B2 (en) 2001-03-08 2010-03-02 Advanced Neuromodulation Systems, Inc. Methods and apparatus for effectuating a lasting change in a neural-function of a patient
US20050021118A1 (en) * 2000-07-13 2005-01-27 Chris Genau Apparatuses and systems for applying electrical stimulation to a patient
US7236831B2 (en) * 2000-07-13 2007-06-26 Northstar Neuroscience, Inc. Methods and apparatus for effectuating a lasting change in a neural-function of a patient
US7010351B2 (en) * 2000-07-13 2006-03-07 Northstar Neuroscience, Inc. Methods and apparatus for effectuating a lasting change in a neural-function of a patient
US7146217B2 (en) * 2000-07-13 2006-12-05 Northstar Neuroscience, Inc. Methods and apparatus for effectuating a change in a neural-function of a patient
US7024247B2 (en) * 2001-10-15 2006-04-04 Northstar Neuroscience, Inc. Systems and methods for reducing the likelihood of inducing collateral neural activity during neural stimulation threshold test procedures
US20030125786A1 (en) * 2000-07-13 2003-07-03 Gliner Bradford Evan Methods and apparatus for effectuating a lasting change in a neural-function of a patient
US7756584B2 (en) * 2000-07-13 2010-07-13 Advanced Neuromodulation Systems, Inc. Methods and apparatus for effectuating a lasting change in a neural-function of a patient
US7305268B2 (en) 2000-07-13 2007-12-04 Northstar Neurscience, Inc. Systems and methods for automatically optimizing stimulus parameters and electrode configurations for neuro-stimulators
US7831305B2 (en) * 2001-10-15 2010-11-09 Advanced Neuromodulation Systems, Inc. Neural stimulation system and method responsive to collateral neural activity
US20040176831A1 (en) * 2000-07-13 2004-09-09 Gliner Bradford Evan Apparatuses and systems for applying electrical stimulation to a patient
EP1303332B1 (en) * 2000-07-26 2004-12-29 Advanced Bionics Corporation Rechargeable spinal cord stimulator system
US6402678B1 (en) 2000-07-31 2002-06-11 Neuralieve, Inc. Means and method for the treatment of migraine headaches
US6497699B1 (en) * 2000-08-09 2002-12-24 The Research Foundation Of State University Of New York Hybrid neuroprosthesis for the treatment of brain disorders
US6591138B1 (en) 2000-08-31 2003-07-08 Neuropace, Inc. Low frequency neurostimulator for the treatment of neurological disorders
US20080177365A1 (en) * 2000-09-27 2008-07-24 Cvrx, Inc. Method and apparatus for electronically switching electrode configuration
US7840271B2 (en) 2000-09-27 2010-11-23 Cvrx, Inc. Stimulus regimens for cardiovascular reflex control
US20070185542A1 (en) * 2002-03-27 2007-08-09 Cvrx, Inc. Baroreflex therapy for disordered breathing
US7623926B2 (en) 2000-09-27 2009-11-24 Cvrx, Inc. Stimulus regimens for cardiovascular reflex control
US7616997B2 (en) * 2000-09-27 2009-11-10 Kieval Robert S Devices and methods for cardiovascular reflex control via coupled electrodes
US7499742B2 (en) * 2001-09-26 2009-03-03 Cvrx, Inc. Electrode structures and methods for their use in cardiovascular reflex control
US8086314B1 (en) * 2000-09-27 2011-12-27 Cvrx, Inc. Devices and methods for cardiovascular reflex control
US7158832B2 (en) * 2000-09-27 2007-01-02 Cvrx, Inc. Electrode designs and methods of use for cardiovascular reflex control devices
US6678548B1 (en) 2000-10-20 2004-01-13 The Trustees Of The University Of Pennsylvania Unified probabilistic framework for predicting and detecting seizure onsets in the brain and multitherapeutic device
WO2002038031A2 (en) * 2000-10-30 2002-05-16 Neuropace, Inc. System and method for determining stimulation parameters for the treatment of epileptic seizures
US7089059B1 (en) 2000-11-03 2006-08-08 Pless Benjamin D Predicting susceptibility to neurological dysfunction based on measured neural electrophysiology
US6591137B1 (en) 2000-11-09 2003-07-08 Neuropace, Inc. Implantable neuromuscular stimulator for the treatment of gastrointestinal disorders
US6529774B1 (en) 2000-11-09 2003-03-04 Neuropace, Inc. Extradural leads, neurostimulator assemblies, and processes of using them for somatosensory and brain stimulation
US7493171B1 (en) 2000-11-21 2009-02-17 Boston Scientific Neuromodulation Corp. Treatment of pathologic craving and aversion syndromes and eating disorders by electrical brain stimulation and/or drug infusion
US6922590B1 (en) 2000-11-21 2005-07-26 Advanced Bionics Corporation Systems and methods for treatment of diabetes by electrical brain stimulation and/or drug infusion
US6950707B2 (en) 2000-11-21 2005-09-27 Advanced Bionics Corporation Systems and methods for treatment of obesity and eating disorders by electrical brain stimulation and/or drug infusion
US7440806B1 (en) 2000-11-21 2008-10-21 Boston Scientific Neuromodulation Corp. Systems and methods for treatment of diabetes by electrical brain stimulation and/or drug infusion
US6832114B1 (en) 2000-11-21 2004-12-14 Advanced Bionics Corporation Systems and methods for modulation of pancreatic endocrine secretion and treatment of diabetes
US6618623B1 (en) 2000-11-28 2003-09-09 Neuropace, Inc. Ferrule for cranial implant
US7158833B2 (en) * 2000-11-28 2007-01-02 Neuropace, Inc. Ferrule for cranial implant
US6594524B2 (en) * 2000-12-12 2003-07-15 The Trustees Of The University Of Pennsylvania Adaptive method and apparatus for forecasting and controlling neurological disturbances under a multi-level control
ES2178946B1 (en) * 2000-12-14 2004-03-16 Univ Coruna MULTI-SENSORY STIMULATION SYSTEM (AUDITIVE-VISUAL-SOMESTIC) MINIATURIZED PORTABLE RHYTHMIC.
US7493172B2 (en) * 2001-01-30 2009-02-17 Boston Scientific Neuromodulation Corp. Methods and systems for stimulating a nerve originating in an upper cervical spine area to treat a medical condition
US20060064140A1 (en) * 2001-01-30 2006-03-23 Whitehurst Todd K Methods and systems for stimulating a trigeminal nerve to treat a psychiatric disorder
US6735475B1 (en) 2001-01-30 2004-05-11 Advanced Bionics Corporation Fully implantable miniature neurostimulator for stimulation as a therapy for headache and/or facial pain
US6597953B2 (en) * 2001-02-20 2003-07-22 Neuropace, Inc. Furcated sensing and stimulation lead
US7299096B2 (en) * 2001-03-08 2007-11-20 Northstar Neuroscience, Inc. System and method for treating Parkinson's Disease and other movement disorders
WO2002073526A2 (en) 2001-03-13 2002-09-19 Wide Horizon Holdings Inc. Cerebral programming
US7288085B2 (en) * 2001-04-10 2007-10-30 Medtronic, Inc. Permanent magnet solenoid pump for an implantable therapeutic substance delivery device
US6671555B2 (en) * 2001-04-27 2003-12-30 Medtronic, Inc. Closed loop neuromodulation for suppression of epileptic activity
US6631291B2 (en) 2001-05-18 2003-10-07 Instrumentarium Corp. Closed loop drug administration method and apparatus using EEG complexity for control purposes
US6810285B2 (en) * 2001-06-28 2004-10-26 Neuropace, Inc. Seizure sensing and detection using an implantable device
US7013177B1 (en) 2001-07-05 2006-03-14 Advanced Bionics Corporation Treatment of pain by brain stimulation
US6606521B2 (en) 2001-07-09 2003-08-12 Neuropace, Inc. Implantable medical lead
EP2159723A1 (en) * 2001-07-11 2010-03-03 CNS Response, Inc. Method for remote diagnosis and treatment using electroencephalografy
EP1450894A4 (en) * 2001-08-20 2006-04-05 Reuven Sandyk Method and apparatus for treatment of patients
US7054686B2 (en) * 2001-08-30 2006-05-30 Biophan Technologies, Inc. Pulsewidth electrical stimulation
US20060241717A1 (en) * 2001-08-30 2006-10-26 Whitehurst Todd K Treatment of movement disorders by extra dural motor cortex stimulation
WO2003026736A2 (en) * 2001-09-28 2003-04-03 Northstar Neuroscience, Inc. Methods and implantable apparatus for electrical therapy
WO2003026738A1 (en) * 2001-09-28 2003-04-03 Northstar Neuroscience, Inc. Methods and apparatus for electrically stimulating cells implanted in the nervous system
IL145700A0 (en) * 2001-09-30 2002-06-30 Younis Imad Electrode system for neural applications
US7136695B2 (en) 2001-10-12 2006-11-14 Pless Benjamin D Patient-specific template development for neurological event detection
US7209788B2 (en) * 2001-10-29 2007-04-24 Duke University Closed loop brain machine interface
US6944497B2 (en) * 2001-10-31 2005-09-13 Medtronic, Inc. System and method of treating stuttering by neuromodulation
US6788976B2 (en) * 2001-11-02 2004-09-07 Lockheed Martin Corporation Movement timing simulator
US6654633B2 (en) 2001-11-07 2003-11-25 Neuralynx, Inc. Mobile neurological signal data acquisition system and method
US20030105409A1 (en) * 2001-11-14 2003-06-05 Donoghue John Philip Neurological signal decoding
US20040006264A1 (en) * 2001-11-20 2004-01-08 Mojarradi Mohammad M. Neural prosthetic micro system
DE10156556A1 (en) * 2001-11-20 2003-07-17 Ags Medicare Gmbh Device for determining sleep profiles
US20030100931A1 (en) * 2001-11-28 2003-05-29 Keith Mullett Brain signal feedback for pain management
US7409373B2 (en) * 2001-12-28 2008-08-05 Concepta Ab Pattern analysis system and method
US20030144711A1 (en) 2002-01-29 2003-07-31 Neuropace, Inc. Systems and methods for interacting with an implantable medical device
WO2009021080A2 (en) * 2007-08-06 2009-02-12 Great Lakes Biosciences, Llc Methods and apparatus for electrical stimulation of tissues using signals that minimize the effects of tissue impedance
WO2003066157A2 (en) * 2002-02-04 2003-08-14 Great Lakes Biosciences, Llc Treatment of neurological disorders using electrical stimulation
US7110820B2 (en) 2002-02-05 2006-09-19 Tcheng Thomas K Responsive electrical stimulation for movement disorders
US20070216865A1 (en) * 2002-02-08 2007-09-20 Novavision, Inc. Process and Device for Apportioning Therapeutic Vision Stimuli
US20030171738A1 (en) * 2002-03-06 2003-09-11 Konieczynski David D. Convection-enhanced drug delivery device and method of use
US7108680B2 (en) * 2002-03-06 2006-09-19 Codman & Shurtleff, Inc. Closed-loop drug delivery system
DE10211766B4 (en) * 2002-03-14 2004-07-01 Forschungszentrum Jülich GmbH Device for treating patients by means of brain stimulation and the use of the device in medicine
US6993392B2 (en) * 2002-03-14 2006-01-31 Duke University Miniaturized high-density multichannel electrode array for long-term neuronal recordings
US7221981B2 (en) 2002-03-28 2007-05-22 Northstar Neuroscience, Inc. Electrode geometries for efficient neural stimulation
US7146222B2 (en) * 2002-04-15 2006-12-05 Neurospace, Inc. Reinforced sensing and stimulation leads and use in detection systems
US6898461B2 (en) * 2002-04-23 2005-05-24 Medtronic, Inc. Implantable medical device stream processor
US7636597B2 (en) * 2002-11-14 2009-12-22 Brainsgate, Ltd. Surgical tools and techniques for stimulation
US7684859B2 (en) * 2002-04-25 2010-03-23 Brainsgate Ltd. Stimulation of the OTIC ganglion for treating medical conditions
IL164828A0 (en) * 2002-04-25 2005-12-18 Brainsgate Ltd Methods and apparatus for modifying properties of the bbb and cerebral circulation by using the neuroexcitatory and/or neuroinhibitory effects of odorants on nerves in the head
US6937891B2 (en) 2002-04-26 2005-08-30 Medtronic, Inc. Independent therapy programs in an implantable medical device
US7003352B1 (en) 2002-05-24 2006-02-21 Advanced Bionics Corporation Treatment of epilepsy by brain stimulation
US7151961B1 (en) * 2002-05-24 2006-12-19 Advanced Bionics Corporation Treatment of movement disorders by brain stimulation
US20050182453A1 (en) * 2002-05-24 2005-08-18 Whitehurst Todd K. Treatment of epilepsy by high frequency electrical stimulation and/or drug stimulation
WO2003101532A2 (en) * 2002-06-04 2003-12-11 Cyberkinetics, Inc. Optically-connected implants and related systems and methods of use
US6916294B2 (en) * 2002-07-09 2005-07-12 George Washington University Brain retraction sensor
US7153279B2 (en) * 2002-07-09 2006-12-26 George Washington University Brain retraction sensor
US6934580B1 (en) * 2002-07-20 2005-08-23 Flint Hills Scientific, L.L.C. Stimulation methodologies and apparatus for control of brain states
US7254449B2 (en) * 2002-07-31 2007-08-07 Advanced Bionics Corp Systems and methods for providing power to one or more implantable devices
EP1540908A4 (en) * 2002-08-27 2009-07-01 Univ Florida Optimization of multi-dimensional time series processing for seizure warning and prediction
US7263467B2 (en) * 2002-09-30 2007-08-28 University Of Florida Research Foundation Inc. Multi-dimensional multi-parameter time series processing for seizure warning and prediction
US20060287607A1 (en) * 2002-08-27 2006-12-21 University Of Florida Research Foundation, Inc. Multi-dimensional dynamical analysis
US7623929B1 (en) * 2002-08-30 2009-11-24 Advanced Bionics, Llc Current sensing coil for cochlear implant data detection
US7277748B2 (en) * 2002-09-13 2007-10-02 Neuropace, Inc. Spatiotemporal pattern recognition for neurological event detection and prediction in an implantable device
US20050075679A1 (en) * 2002-09-30 2005-04-07 Gliner Bradford E. Methods and apparatuses for treating neurological disorders by electrically stimulating cells implanted in the nervous system
WO2004033034A1 (en) * 2002-10-04 2004-04-22 Microchips, Inc. Medical device for neural stimulation and controlled drug delivery
US7460904B2 (en) * 2002-10-09 2008-12-02 Wake Forest University Health Sciences Wireless systems and methods for the detection of neural events using onboard processing
EP1558129B1 (en) 2002-10-15 2009-11-25 Medtronic, Inc. Phase shifting of neurological signals in a medical device system
EP1565102A4 (en) 2002-10-15 2008-05-28 Medtronic Inc Synchronization and calibration of clocks for a medical device and calibrated clock
US20040138518A1 (en) * 2002-10-15 2004-07-15 Medtronic, Inc. Medical device system with relaying module for treatment of nervous system disorders
US8738136B2 (en) * 2002-10-15 2014-05-27 Medtronic, Inc. Clustering of recorded patient neurological activity to determine length of a neurological event
WO2004034880A2 (en) 2002-10-15 2004-04-29 Medtronic Inc. Timed delay for redelivery of treatment therapy for a medical device system
EP1562674A4 (en) * 2002-10-15 2008-10-08 Medtronic Inc Control of treatment therapy during start-up and during operation of a medical device system
WO2004034885A2 (en) 2002-10-15 2004-04-29 Medtronic Inc. Signal quality monitoring and control for a medical device system
EP1558330A4 (en) * 2002-10-15 2008-10-01 Medtronic Inc Cycle mode providing redundant back-up to ensure termination of treatment therapy in a medical device system
AU2003301481A1 (en) * 2002-10-15 2004-05-04 Medtronic Inc. Channel-selective blanking for a medical device system
US20040153436A1 (en) * 2002-10-15 2004-08-05 Pope Cameron A. Automated information management system and methods
WO2004036372A2 (en) * 2002-10-15 2004-04-29 Medtronic Inc. Scoring of sensed neurological signals for use with a medical device system
AU2003301370A1 (en) * 2002-10-15 2004-05-04 Medtronic Inc. Multi-modal operation of a medical device system
AU2003287162A1 (en) * 2002-10-15 2004-05-04 Medtronic Inc. Configuring and testing treatment therapy parameters for a medical device system
WO2004034879A2 (en) * 2002-10-15 2004-04-29 Medtronic Inc. Screening techniques for management of a nervous system disorder
KR20050083814A (en) * 2002-10-24 2005-08-26 록히드 마틴 코포레이션 Systems and methods for treating movement disorders
US7212851B2 (en) * 2002-10-24 2007-05-01 Brown University Research Foundation Microstructured arrays for cortex interaction and related methods of manufacture and use
US7236830B2 (en) 2002-12-10 2007-06-26 Northstar Neuroscience, Inc. Systems and methods for enhancing or optimizing neural stimulation therapy for treating symptoms of Parkinson's disease and/or other movement disorders
US7031765B2 (en) 2002-11-11 2006-04-18 Medtronic, Inc Algorithms for detecting atrial arrhythmias from discriminatory signatures of ventricular cycle lengths
WO2004043536A1 (en) 2002-11-12 2004-05-27 Neuropace, Inc. System for adaptive brain stimulation
US7561919B2 (en) * 2002-11-14 2009-07-14 Brainsgate Ltd. SPG stimulation via the greater palatine canal
US20050075680A1 (en) * 2003-04-18 2005-04-07 Lowry David Warren Methods and systems for intracranial neurostimulation and/or sensing
US7302298B2 (en) * 2002-11-27 2007-11-27 Northstar Neuroscience, Inc Methods and systems employing intracranial electrodes for neurostimulation and/or electroencephalography
US7189204B2 (en) * 2002-12-04 2007-03-13 Cardiac Pacemakers, Inc. Sleep detection using an adjustable threshold
US7596408B2 (en) * 2002-12-09 2009-09-29 Medtronic, Inc. Implantable medical device with anti-infection agent
EP1578494B1 (en) * 2002-12-09 2010-05-26 Medtronic, Inc. Lead connection module of a modular implantable medical device
US7565199B2 (en) * 2002-12-09 2009-07-21 Advanced Neuromodulation Systems, Inc. Methods for treating and/or collecting information regarding neurological disorders, including language disorders
US6959215B2 (en) * 2002-12-09 2005-10-25 Northstar Neuroscience, Inc. Methods for treating essential tremor
AU2003296956A1 (en) * 2002-12-11 2004-06-30 Proteus Biomedical, Inc. Monitoring and treating hemodynamic parameters
US6902544B2 (en) * 2003-01-22 2005-06-07 Codman & Shurtleff, Inc. Troubleshooting accelerator system for implantable drug delivery pumps
EP1585441A4 (en) * 2003-01-24 2008-05-21 Proteus Biomedical Inc Methods and systems for measuring cardiac parameters
WO2004071737A2 (en) * 2003-02-04 2004-08-26 Arizona Board Of Regents, Acting For And On Behalf Of Arizona State University (Abr/Asu) Using benzocyclobutene as a biocompatible material
US20060111626A1 (en) * 2003-03-27 2006-05-25 Cvrx, Inc. Electrode structures having anti-inflammatory properties and methods of use
WO2005000153A2 (en) * 2003-04-24 2005-01-06 Northstar Neuroscience, Inc. Systems and methods for facilitating and/or effectuating development, rehabilitation, restoration, and/or recovery of visual function through neural stimulation
US7130678B2 (en) * 2003-04-25 2006-10-31 Medtronic, Inc. Adaptive memory prioritization for implanted medical devices
US20040225335A1 (en) * 2003-05-08 2004-11-11 Whitehurst Todd K. Treatment of Huntington's disease by brain stimulation
US7317947B2 (en) * 2003-05-16 2008-01-08 Medtronic, Inc. Headset recharger for cranially implantable medical devices
US20050004637A1 (en) * 2003-05-16 2005-01-06 Ruchika Singhal Explantation of implantable medical device
US20050003268A1 (en) * 2003-05-16 2005-01-06 Scott Erik R. Battery housing configuration
US7263401B2 (en) * 2003-05-16 2007-08-28 Medtronic, Inc. Implantable medical device with a nonhermetic battery
US7738952B2 (en) 2003-06-09 2010-06-15 Palo Alto Investors Treatment of conditions through modulation of the autonomic nervous system
US20040249302A1 (en) * 2003-06-09 2004-12-09 Cyberkinetics, Inc. Methods and systems for processing of brain signals
CA2432810A1 (en) * 2003-06-19 2004-12-19 Andres M. Lozano Method of treating depression, mood disorders and anxiety disorders by brian infusion
AU2004261290A1 (en) * 2003-08-01 2005-02-10 Northstar Neuroscience, Inc. Apparatus and methods for applying neural stimulation to a patient
US8606356B2 (en) 2003-09-18 2013-12-10 Cardiac Pacemakers, Inc. Autonomic arousal detection system and method
DE10338953B4 (en) * 2003-08-25 2008-11-20 Wietholt, Dietmar, Dr. Device for stimulating the brain in humans or mammals with a tendency to epileptic seizures
US20050102006A1 (en) * 2003-09-25 2005-05-12 Whitehurst Todd K. Skull-mounted electrical stimulation system
US8190248B2 (en) * 2003-10-16 2012-05-29 Louisiana Tech University Foundation, Inc. Medical devices for the detection, prevention and/or treatment of neurological disorders, and methods related thereto
US7548775B2 (en) 2003-10-21 2009-06-16 The Regents Of The University Of Michigan Intracranial neural interface system
US7480532B2 (en) * 2003-10-22 2009-01-20 Cvrx, Inc. Baroreflex activation for pain control, sedation and sleep
US20080208288A1 (en) * 2003-10-24 2008-08-28 Lockheed Martin Corporation Systems and methods for treating movement disorders
US20050143589A1 (en) * 2003-11-09 2005-06-30 Donoghue John P. Calibration systems and methods for neural interface devices
US20050113744A1 (en) * 2003-11-21 2005-05-26 Cyberkinetics, Inc. Agent delivery systems and related methods under control of biological electrical signals
US7751877B2 (en) * 2003-11-25 2010-07-06 Braingate Co., Llc Neural interface system with embedded id
US9050469B1 (en) 2003-11-26 2015-06-09 Flint Hills Scientific, Llc Method and system for logging quantitative seizure information and assessing efficacy of therapy using cardiac signals
US20050159671A1 (en) * 2003-12-18 2005-07-21 Sneddo & Associates Inc. Method for diagnosing, detecting, and monitoring brain function including neurological disease and disorders
WO2005062829A2 (en) * 2003-12-19 2005-07-14 Advanced Bionics Corporation Skull-mounted electrical stimulation system and method for treating patients
US8060207B2 (en) 2003-12-22 2011-11-15 Boston Scientific Scimed, Inc. Method of intravascularly delivering stimulation leads into direct contact with tissue
US20050137646A1 (en) * 2003-12-22 2005-06-23 Scimed Life Systems, Inc. Method of intravascularly delivering stimulation leads into brain
US7647097B2 (en) * 2003-12-29 2010-01-12 Braingate Co., Llc Transcutaneous implant
US20070173732A1 (en) * 2004-01-29 2007-07-26 Elvir Causevic Method and apparatus for wireless brain interface
US8086318B2 (en) * 2004-02-12 2011-12-27 Ndi Medical, Llc Portable assemblies, systems, and methods for providing functional or therapeutic neurostimulation
US8055347B2 (en) 2005-08-19 2011-11-08 Brainsgate Ltd. Stimulation for treating brain events and other conditions
US7295875B2 (en) * 2004-02-20 2007-11-13 Boston Scientific Scimed, Inc. Method of stimulating/sensing brain with combination of intravascularly and non-vascularly delivered leads
US9233245B2 (en) 2004-02-20 2016-01-12 Brainsgate Ltd. SPG stimulation
US8010189B2 (en) * 2004-02-20 2011-08-30 Brainsgate Ltd. SPG stimulation for treating complications of subarachnoid hemorrhage
US7590454B2 (en) * 2004-03-12 2009-09-15 Boston Scientific Neuromodulation Corporation Modular stimulation lead network
US20050203600A1 (en) 2004-03-12 2005-09-15 Scimed Life Systems, Inc. Collapsible/expandable tubular electrode leads
US20050203366A1 (en) * 2004-03-12 2005-09-15 Donoghue John P. Neurological event monitoring and therapy systems and related methods
US7177702B2 (en) 2004-03-12 2007-02-13 Scimed Life Systems, Inc. Collapsible/expandable electrode leads
WO2005092185A2 (en) 2004-03-22 2005-10-06 California Institute Of Technology Cognitive control signals for neural prosthetics
US7283856B2 (en) * 2004-04-09 2007-10-16 Neuro Pace, Inc. Implantable lead system with seed electrodes
US9011329B2 (en) * 2004-04-19 2015-04-21 Searete Llc Lumenally-active device
US8512219B2 (en) 2004-04-19 2013-08-20 The Invention Science Fund I, Llc Bioelectromagnetic interface system
US8361013B2 (en) 2004-04-19 2013-01-29 The Invention Science Fund I, Llc Telescoping perfusion management system
US7857767B2 (en) * 2004-04-19 2010-12-28 Invention Science Fund I, Llc Lumen-traveling device
US20070010868A1 (en) * 2004-04-19 2007-01-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Lumenally-active device
US8337482B2 (en) * 2004-04-19 2012-12-25 The Invention Science Fund I, Llc System for perfusion management
US7850676B2 (en) * 2004-04-19 2010-12-14 The Invention Science Fund I, Llc System with a reservoir for perfusion management
US8353896B2 (en) * 2004-04-19 2013-01-15 The Invention Science Fund I, Llc Controllable release nasal system
US8092549B2 (en) 2004-09-24 2012-01-10 The Invention Science Fund I, Llc Ciliated stent-like-system
US8024036B2 (en) * 2007-03-19 2011-09-20 The Invention Science Fund I, Llc Lumen-traveling biological interface device and method of use
US7998060B2 (en) * 2004-04-19 2011-08-16 The Invention Science Fund I, Llc Lumen-traveling delivery device
US20050234440A1 (en) * 2004-04-19 2005-10-20 Searete Llc, A Limited Liability Corporation Of The State Of Delaware System with a sensor for perfusion management
US7596399B2 (en) * 2004-04-29 2009-09-29 Medtronic, Inc Implantation of implantable medical device
EP1750800A1 (en) 2004-04-30 2007-02-14 Advanced Neuromodulation Systems, Inc. Method of treating mood disorders and/or anxiety disorders by brain stimulation
US20050245984A1 (en) * 2004-04-30 2005-11-03 Medtronic, Inc. Implantable medical device with lubricious material
US8412348B2 (en) 2004-05-06 2013-04-02 Boston Scientific Neuromodulation Corporation Intravascular self-anchoring integrated tubular electrode body
DE102004025825A1 (en) * 2004-05-24 2005-12-29 Forschungszentrum Jülich GmbH Apparatus for treating patients by brain stimulation, an electronic component and the use of the device and the electronic component in medicine and medical treatment method
US7656673B1 (en) * 2004-05-25 2010-02-02 University Of South Florida Wireless micro-electro-opto-fluidic-mechanical foldable flex system
WO2005117797A2 (en) * 2004-05-26 2005-12-15 The Metrohealth System Method and apparatus for relief of headache
WO2005117693A1 (en) * 2004-05-27 2005-12-15 Children's Medical Center Corporation Patient-specific seizure onset detection system
US20050267555A1 (en) 2004-05-28 2005-12-01 Marnfeldt Goran N Engagement tool for implantable medical devices
US7747323B2 (en) 2004-06-08 2010-06-29 Cardiac Pacemakers, Inc. Adaptive baroreflex stimulation therapy for disordered breathing
US7596413B2 (en) * 2004-06-08 2009-09-29 Cardiac Pacemakers, Inc. Coordinated therapy for disordered breathing including baroreflex modulation
EP2260760B1 (en) * 2004-06-18 2014-08-27 Neuronetrix Solutions, LLC Evoked response testing method for neurological disorders
US20060004417A1 (en) * 2004-06-30 2006-01-05 Cvrx, Inc. Baroreflex activation for arrhythmia treatment
US7346382B2 (en) 2004-07-07 2008-03-18 The Cleveland Clinic Foundation Brain stimulation models, systems, devices, and methods
US20060009814A1 (en) * 2004-07-07 2006-01-12 Alfred E. Mann Foundation For Scientific Research Brian implant device
US20080027513A1 (en) * 2004-07-09 2008-01-31 Advanced Bionics Corporation Systems And Methods For Using A Butterfly Coil To Communicate With Or Transfer Power To An Implantable Medical Device
US9044201B2 (en) * 2004-07-12 2015-06-02 St. Jude Medical Coordination Center Bvba Wireless communication of physiological variables using spread spectrum
US20060009817A1 (en) * 2004-07-12 2006-01-12 Radi Medical Systems Ab Wireless communication of physiological variables
US7483747B2 (en) * 2004-07-15 2009-01-27 Northstar Neuroscience, Inc. Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy
US7286879B2 (en) 2004-07-16 2007-10-23 Boston Scientific Scimed, Inc. Method of stimulating fastigium nucleus to treat neurological disorders
US7486993B2 (en) * 2004-08-05 2009-02-03 Neurotone Systems, Inc. Brain stimulation method and device
US20060049957A1 (en) * 2004-08-13 2006-03-09 Surgenor Timothy R Biological interface systems with controlled device selector and related methods
US8452407B2 (en) * 2004-08-16 2013-05-28 Boston Scientific Neuromodulation Corporation Methods for treating gastrointestinal disorders
WO2006021957A2 (en) * 2004-08-23 2006-03-02 Brainsgate Ltd. Concurrent bilateral spg modulation
EP1799101A4 (en) * 2004-09-02 2008-11-19 Proteus Biomedical Inc Methods and apparatus for tissue activation and monitoring
US20060058854A1 (en) * 2004-09-14 2006-03-16 Scimed Life Systems, Inc. Method for stimulating neural tissue in response to a sensed physiological event
US7353065B2 (en) * 2004-09-14 2008-04-01 Neuropace, Inc. Responsive therapy for psychiatric disorders
US8560041B2 (en) * 2004-10-04 2013-10-15 Braingate Co., Llc Biological interface system
US8473060B2 (en) 2004-10-05 2013-06-25 The Trustees Of Dartmouth College Apparatus and method for modulating neurochemical levels in the brain
US20060195157A1 (en) * 2004-10-05 2006-08-31 Dartmouth College Apparatus and method for modulating neurochemical levels in the brain
US7288066B2 (en) * 2004-11-01 2007-10-30 Medtronic, Inc. Data compression method for implantable medical devices
US8768446B2 (en) * 2004-11-02 2014-07-01 Medtronic, Inc. Clustering with combined physiological signals
US7917199B2 (en) * 2004-11-02 2011-03-29 Medtronic, Inc. Patient event marking in combination with physiological signals
US8024029B2 (en) * 2004-11-02 2011-09-20 Medtronic, Inc. Techniques for user-activated data retention in an implantable medical device
ATE481920T1 (en) * 2004-11-02 2010-10-15 Medtronic Inc METHOD FOR DATA RETENTION IN AN IMPLANTABLE MEDICAL DEVICE
US20060094974A1 (en) * 2004-11-02 2006-05-04 Cain Robert C Systems and methods for detecting brain waves
US20130197944A1 (en) * 2004-11-02 2013-08-01 Medtronic, Inc. Techniques for Data Reporting in an Implantable Medical Device
US9358393B1 (en) 2004-11-09 2016-06-07 Andres M. Lozano Stimulation methods and systems for treating an auditory dysfunction
US7565200B2 (en) 2004-11-12 2009-07-21 Advanced Neuromodulation Systems, Inc. Systems and methods for selecting stimulation sites and applying treatment, including treatment of symptoms of Parkinson's disease, other movement disorders, and/or drug side effects
US20060106430A1 (en) * 2004-11-12 2006-05-18 Brad Fowler Electrode configurations for reducing invasiveness and/or enhancing neural stimulation efficacy, and associated methods
US7483746B2 (en) * 2004-12-06 2009-01-27 Boston Scientific Neuromodulation Corp. Stimulation of the stomach in response to sensed parameters to treat obesity
US7366571B2 (en) * 2004-12-10 2008-04-29 Cyberonics, Inc. Neurostimulator with activation based on changes in body temperature
US20060129056A1 (en) * 2004-12-10 2006-06-15 Washington University Electrocorticography telemitter
US7937160B2 (en) * 2004-12-10 2011-05-03 Boston Scientific Neuromodulation Corporation Methods for delivering cortical electrode leads into patient's head
US7819812B2 (en) 2004-12-15 2010-10-26 Neuropace, Inc. Modulation and analysis of cerebral perfusion in epilepsy and other neurological disorders
US7341562B2 (en) * 2004-12-15 2008-03-11 Neuropace, Inc. Modulation and analysis of cerebral perfusion in epilepsy and other neurological disorders
US7797040B2 (en) 2004-12-16 2010-09-14 California Institute Of Technology Prosthetic devices and methods and systems related thereto
US8485979B2 (en) * 2004-12-17 2013-07-16 Medtronic, Inc. System and method for monitoring or treating nervous system disorders
US8214035B2 (en) * 2004-12-17 2012-07-03 Medtronic, Inc. System and method for utilizing brain state information to modulate cardiac therapy
US20070239060A1 (en) * 2004-12-17 2007-10-11 Medtronic, Inc. System and method for regulating cardiac triggered therapy to the brain
US8112153B2 (en) * 2004-12-17 2012-02-07 Medtronic, Inc. System and method for monitoring or treating nervous system disorders
US20070239230A1 (en) * 2004-12-17 2007-10-11 Medtronic, Inc. System and method for regulating cardiac triggered therapy to the brain
US8112148B2 (en) * 2004-12-17 2012-02-07 Medtronic, Inc. System and method for monitoring cardiac signal activity in patients with nervous system disorders
US8209009B2 (en) * 2004-12-17 2012-06-26 Medtronic, Inc. System and method for segmenting a cardiac signal based on brain stimulation
US8041418B2 (en) * 2004-12-17 2011-10-18 Medtronic, Inc. System and method for regulating cardiac triggered therapy to the brain
US8108046B2 (en) 2004-12-17 2012-01-31 Medtronic, Inc. System and method for using cardiac events to trigger therapy for treating nervous system disorders
US8108038B2 (en) * 2004-12-17 2012-01-31 Medtronic, Inc. System and method for segmenting a cardiac signal based on brain activity
US8209019B2 (en) 2004-12-17 2012-06-26 Medtronic, Inc. System and method for utilizing brain state information to modulate cardiac therapy
EP3150121B1 (en) * 2004-12-20 2018-10-03 UNEEG medical A/S Device for prediction and warning of hypoglycaemic attack
WO2006069144A2 (en) * 2004-12-21 2006-06-29 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Deep brain stimulation apparatus, and associated methods
US9095713B2 (en) * 2004-12-21 2015-08-04 Allison M. Foster Methods and systems for treating autism by decreasing neural activity within the brain
US9327069B2 (en) 2004-12-21 2016-05-03 Boston Scientific Neuromodulation Corporation Methods and systems for treating a medical condition by promoting neural remodeling within the brain
US20060161217A1 (en) * 2004-12-21 2006-07-20 Jaax Kristen N Methods and systems for treating obesity
US20070038264A1 (en) * 2004-12-21 2007-02-15 Jaax Kristen N Methods and systems for treating autism
US8515541B1 (en) 2004-12-22 2013-08-20 Boston Scientific Neuromodulation Corporation Methods and systems for treating post-stroke disorders
US9352145B2 (en) * 2004-12-22 2016-05-31 Boston Scientific Neuromodulation Corporation Methods and systems for treating a psychotic disorder
US8095209B2 (en) * 2005-01-06 2012-01-10 Braingate Co., Llc Biological interface system with gated control signal
US7991461B2 (en) * 2005-01-06 2011-08-02 Braingate Co., Llc Patient training routine for biological interface system
WO2006074029A2 (en) * 2005-01-06 2006-07-13 Cyberkinetics Neurotechnology Systems, Inc. Neurally controlled and multi-device patient ambulation systems and related methods
US8812096B2 (en) * 2005-01-10 2014-08-19 Braingate Co., Llc Biological interface system with patient training apparatus
US20060167564A1 (en) * 2005-01-10 2006-07-27 Flaherty J C Limb and digit movement system
US7775966B2 (en) 2005-02-24 2010-08-17 Ethicon Endo-Surgery, Inc. Non-invasive pressure measurement in a fluid adjustable restrictive device
US7881780B2 (en) * 2005-01-18 2011-02-01 Braingate Co., Llc Biological interface system with thresholded configuration
US8600521B2 (en) * 2005-01-27 2013-12-03 Cyberonics, Inc. Implantable medical device having multiple electrode/sensor capability and stimulation based on sensed intrinsic activity
US7454245B2 (en) 2005-01-28 2008-11-18 Cyberonics, Inc. Trained and adaptive response in a neurostimulator
US8260426B2 (en) * 2008-01-25 2012-09-04 Cyberonics, Inc. Method, apparatus and system for bipolar charge utilization during stimulation by an implantable medical device
US8565867B2 (en) * 2005-01-28 2013-10-22 Cyberonics, Inc. Changeable electrode polarity stimulation by an implantable medical device
US7561918B2 (en) 2005-01-28 2009-07-14 Cyberonics, Inc. Autocapture in a neurostimulator
US9314633B2 (en) 2008-01-25 2016-04-19 Cyberonics, Inc. Contingent cardio-protection for epilepsy patients
US20060293578A1 (en) * 2005-02-03 2006-12-28 Rennaker Robert L Ii Brian machine interface device
US7699770B2 (en) 2005-02-24 2010-04-20 Ethicon Endo-Surgery, Inc. Device for non-invasive measurement of fluid pressure in an adjustable restriction device
US8016744B2 (en) 2005-02-24 2011-09-13 Ethicon Endo-Surgery, Inc. External pressure-based gastric band adjustment system and method
US7927270B2 (en) 2005-02-24 2011-04-19 Ethicon Endo-Surgery, Inc. External mechanical pressure sensor for gastric band pressure measurements
US20060212097A1 (en) * 2005-02-24 2006-09-21 Vijay Varadan Method and device for treatment of medical conditions and monitoring physical movements
US8066629B2 (en) 2005-02-24 2011-11-29 Ethicon Endo-Surgery, Inc. Apparatus for adjustment and sensing of gastric band pressure
US7658196B2 (en) 2005-02-24 2010-02-09 Ethicon Endo-Surgery, Inc. System and method for determining implanted device orientation
US7775215B2 (en) 2005-02-24 2010-08-17 Ethicon Endo-Surgery, Inc. System and method for determining implanted device positioning and obtaining pressure data
WO2006094072A2 (en) * 2005-03-01 2006-09-08 Functional Neuroscience Inc. Method of treating cognitive disorders using neuromodulation
CA2599959A1 (en) * 2005-03-01 2006-09-08 Functional Neuroscience Inc. Method of treating depression, mood disorders and anxiety disorders using neuromodulation
US20060200205A1 (en) * 2005-03-01 2006-09-07 Haller Matthew I Systems and methods for treating a patient with multiple stimulation therapies
US7231256B2 (en) * 2005-03-11 2007-06-12 Medtronic, Inc. Neurostimulation site screening
US7555345B2 (en) * 2005-03-11 2009-06-30 Medtronic, Inc. Implantable neurostimulator device
US7853321B2 (en) * 2005-03-14 2010-12-14 Boston Scientific Neuromodulation Corporation Stimulation of a stimulation site within the neck or head
US7702385B2 (en) * 2005-11-16 2010-04-20 Boston Scientific Neuromodulation Corporation Electrode contact configurations for an implantable stimulator
US7848803B1 (en) 2005-03-14 2010-12-07 Boston Scientific Neuromodulation Corporation Methods and systems for facilitating stimulation of one or more stimulation sites
US8423155B1 (en) 2005-03-14 2013-04-16 Boston Scientific Neuromodulation Corporation Methods and systems for facilitating stimulation of one or more stimulation sites
US7627383B2 (en) * 2005-03-15 2009-12-01 Boston Scientific Neuromodulation Corporation Implantable stimulator
JP5027797B2 (en) * 2005-03-31 2012-09-19 プロテウス バイオメディカル インコーポレイテッド Automatic optimization of multi-electrode pacing for cardiac resynchronization
US8473049B2 (en) * 2005-05-25 2013-06-25 Cardiac Pacemakers, Inc. Implantable neural stimulator with mode switching
US9211408B2 (en) 2005-04-13 2015-12-15 The Cleveland Clinic Foundation System and method for neuromodulation using composite patterns of stimulation or waveforms
US9339650B2 (en) 2005-04-13 2016-05-17 The Cleveland Clinic Foundation Systems and methods for neuromodulation using pre-recorded waveforms
US8112154B2 (en) * 2005-04-13 2012-02-07 The Cleveland Clinic Foundation Systems and methods for neuromodulation using pre-recorded waveforms
US7715912B2 (en) * 2005-04-13 2010-05-11 Intelect Medical, Inc. System and method for providing a waveform for stimulating biological tissue
US20070010862A1 (en) * 2005-04-26 2007-01-11 Thomas Osypka Apparatus and method for providing an electrical field to a targeted area
US7200504B1 (en) 2005-05-16 2007-04-03 Advanced Bionics Corporation Measuring temperature change in an electronic biomedical implant
US7395119B2 (en) 2005-05-19 2008-07-01 Cvrx, Inc. Implantable electrode assembly having reverse electrode configuration
US7801600B1 (en) * 2005-05-26 2010-09-21 Boston Scientific Neuromodulation Corporation Controlling charge flow in the electrical stimulation of tissue
US7818052B2 (en) * 2005-06-01 2010-10-19 Advanced Bionics, Llc Methods and systems for automatically identifying whether a neural recording signal includes a neural response signal
US7447549B2 (en) * 2005-06-01 2008-11-04 Advanced Bionioics, Llc Methods and systems for denoising a neural recording signal
US7343200B2 (en) * 2005-06-01 2008-03-11 Advanced Bionics, Llc Methods and systems for automatically determining a neural response threshold current level
US9014796B2 (en) 2005-06-14 2015-04-21 Regents Of The University Of Michigan Flexible polymer microelectrode with fluid delivery capability and methods for making same
US7740588B1 (en) * 2005-06-24 2010-06-22 Michael Sciarra Wireless respiratory and heart rate monitoring system
US20090299447A1 (en) * 2005-07-01 2009-12-03 Marc Jensen Deployable epicardial electrode and sensor array
WO2007007058A1 (en) * 2005-07-07 2007-01-18 Isis Innovation Limited Method and apparatus for regulating blood pressure
US20090216146A1 (en) * 2005-07-07 2009-08-27 Mina Teicher Method and System for Processing and Electroencephalograph (Eeg) Signal
US7711419B2 (en) * 2005-07-13 2010-05-04 Cyberonics, Inc. Neurostimulator with reduced size
US20070118044A1 (en) * 2005-07-18 2007-05-24 Mega Elektroniikka Oy Method and device for identifying; measuring and analyzing abnormal neurological responses
US8926959B2 (en) 2005-07-22 2015-01-06 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US20090093403A1 (en) 2007-03-01 2009-04-09 Feng Zhang Systems, methods and compositions for optical stimulation of target cells
US9238150B2 (en) 2005-07-22 2016-01-19 The Board Of Trustees Of The Leland Stanford Junior University Optical tissue interface method and apparatus for stimulating cells
US10052497B2 (en) 2005-07-22 2018-08-21 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US9274099B2 (en) 2005-07-22 2016-03-01 The Board Of Trustees Of The Leland Stanford Junior University Screening test drugs to identify their effects on cell membrane voltage-gated ion channel
JP2009502140A (en) 2005-07-22 2009-01-29 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー Photoactivated cation channel and use thereof
US20070027499A1 (en) * 2005-07-29 2007-02-01 Cyberonics, Inc. Neurostimulation device for treating mood disorders
US7499752B2 (en) * 2005-07-29 2009-03-03 Cyberonics, Inc. Selective nerve stimulation for the treatment of eating disorders
US7904144B2 (en) * 2005-08-02 2011-03-08 Brainscope Company, Inc. Method for assessing brain function and portable automatic brain function assessment apparatus
US7720530B2 (en) * 2005-08-02 2010-05-18 Brainscope Company, Inc. Field-deployable concussion detector
WO2007021804A2 (en) * 2005-08-12 2007-02-22 Proteus Biomedical, Inc. Evaluation of depolarization wave conduction velocity
US8649876B2 (en) 2005-09-10 2014-02-11 Artann Laboratories Inc. Leadless system for deep brain stimulation using time reversal acoustics
CN101583309B (en) * 2005-10-07 2012-07-04 神经连结科技公司 Modular multichannel microelectrode array and methods of making same
US7729773B2 (en) 2005-10-19 2010-06-01 Advanced Neuromodualation Systems, Inc. Neural stimulation and optical monitoring systems and methods
US20070088403A1 (en) * 2005-10-19 2007-04-19 Allen Wyler Methods and systems for establishing parameters for neural stimulation
US20070088404A1 (en) * 2005-10-19 2007-04-19 Allen Wyler Methods and systems for improving neural functioning, including cognitive functioning and neglect disorders
US8929991B2 (en) 2005-10-19 2015-01-06 Advanced Neuromodulation Systems, Inc. Methods for establishing parameters for neural stimulation, including via performance of working memory tasks, and associated kits
US7856264B2 (en) * 2005-10-19 2010-12-21 Advanced Neuromodulation Systems, Inc. Systems and methods for patient interactive neural stimulation and/or chemical substance delivery
US7489561B2 (en) 2005-10-24 2009-02-10 Cyberonics, Inc. Implantable medical device with reconfigurable non-volatile program
US7620455B2 (en) 2005-10-25 2009-11-17 Cyberonics, Inc. Cranial nerve stimulation to treat eating disorders
US7957796B2 (en) 2005-10-28 2011-06-07 Cyberonics, Inc. Using physiological sensor data with an implantable medical device
US7555344B2 (en) 2005-10-28 2009-06-30 Cyberonics, Inc. Selective neurostimulation for treating epilepsy
US20070106143A1 (en) * 2005-11-08 2007-05-10 Flaherty J C Electrode arrays and related methods
US8204600B2 (en) * 2005-11-22 2012-06-19 Mayo Foundation For Medical Education And Research Detecting and treating nervous system disorders
US7729758B2 (en) * 2005-11-30 2010-06-01 Boston Scientific Neuromodulation Corporation Magnetically coupled microstimulators
WO2007075477A2 (en) * 2005-12-19 2007-07-05 University Of Florida Closed-loop state-dependent seizure prevention systems
US8262556B2 (en) 2005-12-19 2012-09-11 Neuralieve, Inc. Magnetic pulsing system for inducing electric currents in a human body
US20070142888A1 (en) * 2005-12-20 2007-06-21 Alfonso Chavez Implantable leads and methods of using the same
US20070142872A1 (en) * 2005-12-21 2007-06-21 Mickle Marlin H Deep brain stimulation apparatus, and associated methods
EP1968693A4 (en) * 2005-12-22 2011-04-27 Proteus Biomedical Inc Implantable integrated circuit
US20100023021A1 (en) * 2005-12-27 2010-01-28 Flaherty J Christopher Biological Interface and Insertion
US20070156126A1 (en) * 2005-12-29 2007-07-05 Flaherty J C Medical device insertion system and related methods
US8868172B2 (en) * 2005-12-28 2014-10-21 Cyberonics, Inc. Methods and systems for recommending an appropriate action to a patient for managing epilepsy and other neurological disorders
US8725243B2 (en) * 2005-12-28 2014-05-13 Cyberonics, Inc. Methods and systems for recommending an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders
US20070149952A1 (en) * 2005-12-28 2007-06-28 Mike Bland Systems and methods for characterizing a patient's propensity for a neurological event and for communicating with a pharmacological agent dispenser
EP1971394A4 (en) * 2005-12-28 2009-04-01 Neurovista Corp Methods and systems for recommending an action to a patient for managing epilepsy and other neurological disorders
US7610100B2 (en) * 2005-12-30 2009-10-27 Boston Scientific Neuromodulation Corporation Methods and systems for treating osteoarthritis
US7835803B1 (en) 2006-01-17 2010-11-16 Boston Scientific Neuromodulation Corporation Lead assemblies with one or more switching networks
US7996079B2 (en) * 2006-01-24 2011-08-09 Cyberonics, Inc. Input response override for an implantable medical device
US20070173890A1 (en) * 2006-01-24 2007-07-26 Cyberonics, Inc. Stimulation mode adjustment for an implantable medical device
US7657310B2 (en) 2006-01-26 2010-02-02 Cyberonics, Inc. Treatment of reproductive endocrine disorders by vagus nerve stimulation
WO2007089738A2 (en) * 2006-01-26 2007-08-09 The Regents Of The University Of Michigan Microelectrode with laterally extending platform for reduction of tissue encapsulation
US7801601B2 (en) * 2006-01-27 2010-09-21 Cyberonics, Inc. Controlling neuromodulation using stimulus modalities
US20070287931A1 (en) * 2006-02-14 2007-12-13 Dilorenzo Daniel J Methods and systems for administering an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders
US7787945B2 (en) * 2006-03-08 2010-08-31 Neuropace, Inc. Implantable seizure monitor
US7894905B2 (en) * 2006-03-13 2011-02-22 Neuropace, Inc. Implantable system enabling responsive therapy for pain
US20090105782A1 (en) * 2006-03-15 2009-04-23 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Vagus nerve stimulation apparatus, and associated methods
US8190251B2 (en) * 2006-03-24 2012-05-29 Medtronic, Inc. Method and apparatus for the treatment of movement disorders
EP2026874B1 (en) 2006-03-29 2015-05-20 Dignity Health Vagus nerve stimulation system
US7777641B2 (en) * 2006-03-29 2010-08-17 Advanced Bionics, Llc Systems and methods of facilitating communication between a first and second device
US8152710B2 (en) 2006-04-06 2012-04-10 Ethicon Endo-Surgery, Inc. Physiological parameter analysis for an implantable restriction device and a data logger
US8870742B2 (en) 2006-04-06 2014-10-28 Ethicon Endo-Surgery, Inc. GUI for an implantable restriction device and a data logger
US20080058785A1 (en) 2006-04-12 2008-03-06 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Autofluorescent imaging and target ablation
US20120035437A1 (en) 2006-04-12 2012-02-09 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Navigation of a lumen traveling device toward a target
US7610083B2 (en) * 2006-04-27 2009-10-27 Medtronic, Inc. Method and system for loop recording with overlapping events
US7359837B2 (en) * 2006-04-27 2008-04-15 Medtronic, Inc. Peak data retention of signal data in an implantable medical device
US7912537B2 (en) * 2006-04-27 2011-03-22 Medtronic, Inc. Telemetry-synchronized physiological monitoring and therapy delivery systems
US7764988B2 (en) 2006-04-27 2010-07-27 Medtronic, Inc. Flexible memory management scheme for loop recording in an implantable device
US7869885B2 (en) * 2006-04-28 2011-01-11 Cyberonics, Inc Threshold optimization for tissue stimulation therapy
US7962220B2 (en) * 2006-04-28 2011-06-14 Cyberonics, Inc. Compensation reduction in tissue stimulation therapy
US8355789B2 (en) 2006-04-28 2013-01-15 Medtronic, Inc. Method and apparatus providing asynchronous neural stimulation
US9084901B2 (en) 2006-04-28 2015-07-21 Medtronic, Inc. Cranial implant
US8326431B2 (en) * 2006-04-28 2012-12-04 Medtronic, Inc. Implantable medical device for the concurrent treatment of a plurality of neurological disorders and method therefore
US7348805B2 (en) * 2006-05-02 2008-03-25 International Business Machines Corporation Chip-to-chip digital transmission circuit delivering power over signal lines
US8086316B2 (en) * 2006-05-24 2011-12-27 Drexel University Wireless controlled neuromodulation system
EP2029227A1 (en) * 2006-05-31 2009-03-04 St. Jude Medical AB A method in an imd system
US7498516B1 (en) * 2006-06-14 2009-03-03 Boston Scientific Neuromodulation Corporation Feedthru assembly
US8078283B2 (en) 2006-06-20 2011-12-13 Ebr Systems, Inc. Systems and methods for implantable leadless bone stimulation
US7894904B2 (en) * 2006-06-20 2011-02-22 Ebr Systems, Inc. Systems and methods for implantable leadless brain stimulation
US8401654B1 (en) 2006-06-30 2013-03-19 Boston Scientific Neuromodulation Corporation Methods and systems for treating one or more effects of deafferentation
CA2655438A1 (en) * 2006-06-30 2008-01-10 Novavision, Inc. Diagnostic and therapeutic system for eccentric viewing
US8504163B1 (en) 2006-06-30 2013-08-06 Boston Scientific Neuromodulation Corporation Cranially mounted stimulation systems and methods
EP2038004B1 (en) 2006-07-05 2018-01-24 Precisis AG System for treatment of neurological disorders via electrical stimulation
US9101276B2 (en) * 2006-07-06 2015-08-11 Regents Of The University Of Minnesota Analysis of brain patterns using temporal measures
US8073545B2 (en) * 2006-07-21 2011-12-06 Neuropace, Inc. Treatment and warning of recurring therapy and other events using an implantable device
JP2010501204A (en) 2006-07-25 2010-01-21 ノバビジョン， インコーポレイテッド Dynamic stimulation for visual field testing and treatment
US20080103548A1 (en) * 2006-08-02 2008-05-01 Northstar Neuroscience, Inc. Methods for treating neurological disorders, including neuropsychiatric and neuropsychological disorders, and associated systems
US20090210026A1 (en) * 2006-08-17 2009-08-20 Brainsgate Ltd. Spg stimulation for enhancing neurogenesis and brain metabolism
US9162051B2 (en) * 2006-09-21 2015-10-20 Neuropace, Inc. Treatment of language, behavior and social disorders
US7445528B1 (en) 2006-09-29 2008-11-04 Boston Scientific Neuromodulation Corporation Connector assemblies
US20080146958A1 (en) * 2006-10-12 2008-06-19 Kenneth Shane Guillory Self-contained seizure monitor and method
US7818061B1 (en) 2006-10-13 2010-10-19 Advanced Bionics, Llc Systems and methods for detecting an error associated with an implantable device
US7869867B2 (en) 2006-10-27 2011-01-11 Cyberonics, Inc. Implantable neurostimulator with refractory stimulation
US7347746B1 (en) 2006-10-27 2008-03-25 Boston Scientific Neuromodulation Corporation Receptacle connector assembly
US7809437B2 (en) * 2006-11-13 2010-10-05 Advanced Bionics, Llc Methods and systems for removing accumulated charge from one or more electrodes
US7747318B2 (en) * 2006-12-07 2010-06-29 Neuropace, Inc. Functional ferrule
US20080154331A1 (en) * 2006-12-21 2008-06-26 Varghese John Device for multicentric brain modulation, repair and interface
US20080161712A1 (en) 2006-12-27 2008-07-03 Kent Leyde Low Power Device With Contingent Scheduling
WO2008086470A1 (en) 2007-01-10 2008-07-17 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US8267983B2 (en) 2007-01-11 2012-09-18 Scion Neurostim, Llc. Medical devices incorporating thermoelectric transducer and controller
US8696724B2 (en) * 2007-01-11 2014-04-15 Scion Neurostim, Llc. Devices for vestibular or cranial nerve stimulation
US20080177352A1 (en) * 2007-01-22 2008-07-24 Novavision, Inc. Device for Treating Human Vision Using Combined Optical and Electrical Stimulation
DE102007003799A1 (en) * 2007-01-25 2008-07-31 Anm Adaptive Neuromodulation Gmbh Implant for stimulation of nerve cells
US7391257B1 (en) 2007-01-31 2008-06-24 Medtronic, Inc. Chopper-stabilized instrumentation amplifier for impedance measurement
US8265769B2 (en) * 2007-01-31 2012-09-11 Medtronic, Inc. Chopper-stabilized instrumentation amplifier for wireless telemetry
US8540642B2 (en) * 2007-01-31 2013-09-24 Medtronic, Inc. Implantable medical device and method for physiological event monitoring
US7385443B1 (en) * 2007-01-31 2008-06-10 Medtronic, Inc. Chopper-stabilized instrumentation amplifier
US9615744B2 (en) 2007-01-31 2017-04-11 Medtronic, Inc. Chopper-stabilized instrumentation amplifier for impedance measurement
US7769467B1 (en) 2007-01-31 2010-08-03 Advanced Bionics, Llc Level-dependent stimulation methods and systems
US7894890B2 (en) 2007-02-09 2011-02-22 Neuropace, Inc. Devices and methods for monitoring physiological information relating to sleep with an implantable device
US8401609B2 (en) 2007-02-14 2013-03-19 The Board Of Trustees Of The Leland Stanford Junior University System, method and applications involving identification of biological circuits such as neurological characteristics
WO2008103842A2 (en) * 2007-02-21 2008-08-28 Neurovista Corporation Methods and systems for characterizing and generating a patient-specific seizure advisory system
US8731673B2 (en) 2007-02-26 2014-05-20 Sapiens Steering Brain Stimulation B.V. Neural interface system
US20080249591A1 (en) * 2007-04-06 2008-10-09 Northstar Neuroscience, Inc. Controllers for implantable medical devices, and associated methods
US7945323B2 (en) * 2007-04-13 2011-05-17 Boston Scientific Neuromodulation Corporation Treatment of obesity and/or type II diabetes by stimulation of the pituitary gland
US8578118B2 (en) * 2007-04-26 2013-11-05 Medtronic, Inc. Scheme for overwriting stored physiological data in an implantable medical device
US8000788B2 (en) * 2007-04-27 2011-08-16 Medtronic, Inc. Implantable medical device for treating neurological conditions including ECG sensing
US7974701B2 (en) * 2007-04-27 2011-07-05 Cyberonics, Inc. Dosing limitation for an implantable medical device
US8594779B2 (en) * 2007-04-30 2013-11-26 Medtronic, Inc. Seizure prediction
US8781595B2 (en) 2007-04-30 2014-07-15 Medtronic, Inc. Chopper mixer telemetry circuit
US9788750B2 (en) * 2007-04-30 2017-10-17 Medtronic, Inc. Seizure prediction
US9521955B2 (en) * 2007-05-03 2016-12-20 Cornell Research Foundtion, Inc. Subdural electro-optical sensor
US20080319505A1 (en) * 2007-05-09 2008-12-25 Massachusetts Institute Of Technology Integrated Transcranial Current Stimulation and Electroencephalography Device
US20090132002A1 (en) * 2007-05-11 2009-05-21 Cvrx, Inc. Baroreflex activation therapy with conditional shut off
KR100877228B1 (en) * 2007-05-14 2009-01-09 가천의과학대학교 산학협력단 Deep brain stimulation device having wireless power feeding by magnetic induction
KR100877229B1 (en) * 2007-05-14 2009-01-09 가천의과학대학교 산학협력단 Neural electronic interface device for motor and sensory controls of human body
US9421388B2 (en) * 2007-06-01 2016-08-23 Witricity Corporation Power generation for implantable devices
US8131352B2 (en) * 2007-06-20 2012-03-06 Neuropace, Inc. System and method for automatically adjusting detection thresholds in a feedback-controlled neurological event detector
US7801618B2 (en) * 2007-06-22 2010-09-21 Neuropace, Inc. Auto adjusting system for brain tissue stimulator
US20090005756A1 (en) * 2007-06-29 2009-01-01 Boston Scientific Neuromodulation Corporation Methods and Systems of Treating Strabismus
EP2594315A1 (en) * 2007-07-10 2013-05-22 Sapiens Steering Brain Stimulation B.V. Neurostimulation system
US8594794B2 (en) 2007-07-24 2013-11-26 Cvrx, Inc. Baroreflex activation therapy with incrementally changing intensity
WO2009018172A2 (en) 2007-07-27 2009-02-05 Second Sight Medical Products Implantable device for the brain
EP2207590A1 (en) * 2007-09-26 2010-07-21 Medtronic, INC. Therapy program selection
US7623053B2 (en) * 2007-09-26 2009-11-24 Medtronic, Inc. Implantable medical device with low power delta-sigma analog-to-digital converter
US8380314B2 (en) * 2007-09-26 2013-02-19 Medtronic, Inc. Patient directed therapy control
US20090264789A1 (en) * 2007-09-26 2009-10-22 Medtronic, Inc. Therapy program selection
US7714757B2 (en) * 2007-09-26 2010-05-11 Medtronic, Inc. Chopper-stabilized analog-to-digital converter
EP2200692B1 (en) * 2007-09-26 2016-11-09 Medtronic, Inc. Frequency selective monitoring of physiological signals
DE102007046694A1 (en) * 2007-09-28 2009-04-09 Raumedic Ag Sensor system for measuring, transmitting, processing and displaying a brain parameter
WO2009051638A1 (en) 2007-10-16 2009-04-23 Medtronic, Inc. Therapy control based on a patient movement state
US8224417B2 (en) * 2007-10-17 2012-07-17 Neuronexus Technologies, Inc. Guide tube for an implantable device system
WO2009052423A1 (en) * 2007-10-17 2009-04-23 Neuronexus Technologies Three-dimensional system of electrode leads
US8958862B2 (en) * 2007-10-17 2015-02-17 Neuronexus Technologies, Inc. Implantable device including a resorbable carrier
US7860569B2 (en) 2007-10-18 2010-12-28 Brainsgate, Ltd. Long-term SPG stimulation therapy for prevention of vascular dementia
EP2211708A1 (en) 2007-10-23 2010-08-04 Optima Neuroscience, Inc. System for seizure monitoring and detection
US9008782B2 (en) * 2007-10-26 2015-04-14 Medtronic, Inc. Occipital nerve stimulation
CA2696791A1 (en) * 2007-10-26 2009-04-30 Boston Scientific Neuromodulation Corporation Burr hole plug designs
US20090112278A1 (en) 2007-10-30 2009-04-30 Neuropace, Inc. Systems, Methods and Devices for a Skull/Brain Interface
US9179850B2 (en) * 2007-10-30 2015-11-10 Neuropace, Inc. Systems, methods and devices for a skull/brain interface
US10035027B2 (en) 2007-10-31 2018-07-31 The Board Of Trustees Of The Leland Stanford Junior University Device and method for ultrasonic neuromodulation via stereotactic frame based technique
US10434327B2 (en) 2007-10-31 2019-10-08 The Board Of Trustees Of The Leland Stanford Junior University Implantable optical stimulators
US9248280B2 (en) * 2007-11-02 2016-02-02 Boston Scientific Neuromodulation Corporation Closed-loop feedback for steering stimulation energy within tissue
US20090118804A1 (en) * 2007-11-05 2009-05-07 Advanced Bionics Corporation Method of mounting minimally invasive plug electrodes within cranium of patient
US20090125080A1 (en) * 2007-11-12 2009-05-14 Montgomery Jr Erwin B Intraventricular electrodes for electrical stimulation of the brain
WO2009073891A1 (en) * 2007-12-07 2009-06-11 Northstar Neuroscience, Inc. Systems and methods for providing targeted neural stimulation therapy to address neurological disorders, including neuropyschiatric and neuropyschological disorders
US8187163B2 (en) 2007-12-10 2012-05-29 Ethicon Endo-Surgery, Inc. Methods for implanting a gastric restriction device
US8100870B2 (en) 2007-12-14 2012-01-24 Ethicon Endo-Surgery, Inc. Adjustable height gastric restriction devices and methods
US8600512B2 (en) 2007-12-26 2013-12-03 Boston Scientific Neuromodulation Corporation Methods and systems for treating seizures caused by brain stimulation
US20090172640A1 (en) * 2007-12-26 2009-07-02 Medtronic Minimed, Inc. Medical Device With Full Options and Selective Enablement/Disablement
US8377079B2 (en) 2007-12-27 2013-02-19 Ethicon Endo-Surgery, Inc. Constant force mechanisms for regulating restriction devices
US8142452B2 (en) 2007-12-27 2012-03-27 Ethicon Endo-Surgery, Inc. Controlling pressure in adjustable restriction devices
US20090171168A1 (en) 2007-12-28 2009-07-02 Leyde Kent W Systems and Method for Recording Clinical Manifestations of a Seizure
US9259591B2 (en) * 2007-12-28 2016-02-16 Cyberonics, Inc. Housing for an implantable medical device
US8914112B2 (en) * 2008-01-23 2014-12-16 Boston Scienctific Neuromodulation Corporation Methods and systems of treating pancreatitis pain caused by sphincter of Oddi dysfunction
US8571643B2 (en) 2010-09-16 2013-10-29 Flint Hills Scientific, Llc Detecting or validating a detection of a state change from a template of heart rate derivative shape or heart beat wave complex
US9579506B2 (en) 2008-01-25 2017-02-28 Flint Hills Scientific, L.L.C. Contingent cardio-protection for epilepsy patients
CN101925377A (en) * 2008-01-25 2010-12-22 麦德托尼克公司 The detection of Sleep stages
US8337404B2 (en) 2010-10-01 2012-12-25 Flint Hills Scientific, Llc Detecting, quantifying, and/or classifying seizures using multimodal data
US8060209B2 (en) * 2008-01-25 2011-11-15 Boston Scientific Neuromodulation Corporation Methods and systems of treating ischemia pain in visceral organs
US8382667B2 (en) 2010-10-01 2013-02-26 Flint Hills Scientific, Llc Detecting, quantifying, and/or classifying seizures using multimodal data
US8337389B2 (en) 2008-01-28 2012-12-25 Ethicon Endo-Surgery, Inc. Methods and devices for diagnosing performance of a gastric restriction system
US8192350B2 (en) 2008-01-28 2012-06-05 Ethicon Endo-Surgery, Inc. Methods and devices for measuring impedance in a gastric restriction system
US8591395B2 (en) 2008-01-28 2013-11-26 Ethicon Endo-Surgery, Inc. Gastric restriction device data handling devices and methods
WO2009097493A2 (en) * 2008-01-30 2009-08-06 New York University Cortical electrode array and method for stimulating and recording brain activity
US8676322B2 (en) * 2008-01-30 2014-03-18 Boston Scientific Neuromodulation Corporation Methods and systems of treating pancreatitis pain
US7844342B2 (en) 2008-02-07 2010-11-30 Ethicon Endo-Surgery, Inc. Powering implantable restriction systems using light
US8221439B2 (en) 2008-02-07 2012-07-17 Ethicon Endo-Surgery, Inc. Powering implantable restriction systems using kinetic motion
US8114345B2 (en) 2008-02-08 2012-02-14 Ethicon Endo-Surgery, Inc. System and method of sterilizing an implantable medical device
US9220889B2 (en) 2008-02-11 2015-12-29 Intelect Medical, Inc. Directional electrode devices with locating features
US8019440B2 (en) 2008-02-12 2011-09-13 Intelect Medical, Inc. Directional lead assembly
US8591532B2 (en) 2008-02-12 2013-11-26 Ethicon Endo-Sugery, Inc. Automatically adjusting band system
US8057492B2 (en) 2008-02-12 2011-11-15 Ethicon Endo-Surgery, Inc. Automatically adjusting band system with MEMS pump
US8034065B2 (en) 2008-02-26 2011-10-11 Ethicon Endo-Surgery, Inc. Controlling pressure in adjustable restriction devices
WO2009131749A2 (en) 2008-02-28 2009-10-29 Proteus Biomedical, Inc. Integrated circuit implementation and fault control system, device, and method
US8498720B2 (en) 2008-02-29 2013-07-30 Neuronexus Technologies, Inc. Implantable electrode and method of making the same
US8187162B2 (en) 2008-03-06 2012-05-29 Ethicon Endo-Surgery, Inc. Reorientation port
US8233995B2 (en) 2008-03-06 2012-07-31 Ethicon Endo-Surgery, Inc. System and method of aligning an implantable antenna
WO2009122485A1 (en) * 2008-03-31 2009-10-08 岡山県 Biological measurement system and biological stimulation system
US20090247894A1 (en) * 2008-03-31 2009-10-01 Brainscope Company, Inc. Systems and Methods For Neurological Evaluation and Treatment Guidance
US20090264785A1 (en) * 2008-04-18 2009-10-22 Brainscope Company, Inc. Method and Apparatus For Assessing Brain Function Using Diffusion Geometric Analysis
US8041136B2 (en) * 2008-04-21 2011-10-18 Brainscope Company, Inc. System and method for signal processing using fractal dimension analysis
US20090264786A1 (en) * 2008-04-21 2009-10-22 Brainscope Company, Inc. System and Method For Signal Denoising Using Independent Component Analysis and Fractal Dimension Estimation
RU2010147661A (en) 2008-04-23 2012-05-27 Дзе Борд Оф Трастиз Оф Дзе Лелэнд Стэнфорд Джуниор Юниверсити (Us) SYSTEMS, METHODS AND COMPOSITIONS FOR THE OPTICAL STIMULATION OF TARGET CELLS
US8204603B2 (en) 2008-04-25 2012-06-19 Cyberonics, Inc. Blocking exogenous action potentials by an implantable medical device
US8315703B2 (en) * 2008-04-30 2012-11-20 Advanced Neuromodulation Systems, Inc. Methods for targeting deep brain sites to treat mood and/or anxiety disorders
US8473062B2 (en) * 2008-05-01 2013-06-25 Autonomic Technologies, Inc. Method and device for the treatment of headache
US20090281623A1 (en) * 2008-05-12 2009-11-12 Medtronic, Inc. Customization of implantable medical devices
US20090287266A1 (en) * 2008-05-13 2009-11-19 Mark Zdeblick High-voltage tolerant multiplex multi-electrode stimulation systems and methods for using the same
WO2009140283A1 (en) * 2008-05-13 2009-11-19 The Board Of Trustees Of The University Of Illinois Apparatus for managing a neurological disorder
US9272153B2 (en) 2008-05-15 2016-03-01 Boston Scientific Neuromodulation Corporation VOA generation system and method using a fiber specific analysis
BRPI0913285A2 (en) 2008-05-29 2018-10-16 Univ Leland Stanford Junior cell line, system and method for optical control of secondary messengers
AU2009260029B2 (en) 2008-06-17 2016-03-17 The Board Of Trustees Of The Leland Stanford Junior University Methods, systems and devices for optical stimulation of target cells using an optical transmission element
US10711242B2 (en) 2008-06-17 2020-07-14 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for controlling cellular development
US9101759B2 (en) 2008-07-08 2015-08-11 The Board Of Trustees Of The Leland Stanford Junior University Materials and approaches for optical stimulation of the peripheral nervous system
US8425534B2 (en) 2008-07-24 2013-04-23 Boston Scientific Neuromodulation Corporation Cam lock burr hole plug for securing stimulation lead
US8043304B2 (en) * 2008-07-24 2011-10-25 Boston Scientific Neuromodulation Corporation Cam lock burr hole plug for securing retainer/plug base
US20100030227A1 (en) * 2008-07-31 2010-02-04 Medtronic, Inc. Medical lead implantation
US8463383B2 (en) * 2008-08-01 2013-06-11 Ndi Medical, Inc. Portable assemblies, systems, and methods for providing functional or therapeutic neurostimulation
US8262714B2 (en) * 2008-08-05 2012-09-11 Advanced Neuromodulation Systems, Inc. Techniques for selecting signal delivery sites and other parameters for treating depression and other neurological disorders, and associated systems and methods
DK2327015T3 (en) * 2008-09-26 2018-12-03 Sonova Ag WIRELESS UPDATE OF HEARING DEVICES
EP2341858B1 (en) 2008-10-01 2014-02-12 Sherwin Hua System for wire-guided pedicle screw stabilization of spinal vertebrae
US8280516B2 (en) * 2008-10-09 2012-10-02 Daniel Graupe Method and apparatus for closed-loop deep brain stimulation in treating neurological diseases
US8457747B2 (en) 2008-10-20 2013-06-04 Cyberonics, Inc. Neurostimulation with signal duration determined by a cardiac cycle
US8417344B2 (en) 2008-10-24 2013-04-09 Cyberonics, Inc. Dynamic cranial nerve stimulation based on brain state determination from cardiac data
US8958868B2 (en) * 2008-10-28 2015-02-17 Georgia Tech Research Corporation Systems and methods for multichannel wireless implantable neural recording
US9393432B2 (en) 2008-10-31 2016-07-19 Medtronic, Inc. Non-hermetic direct current interconnect
US20100113964A1 (en) * 2008-10-31 2010-05-06 Wahlstrand John D Determining intercardiac impedance
US8478402B2 (en) * 2008-10-31 2013-07-02 Medtronic, Inc. Determining intercardiac impedance
US10369353B2 (en) 2008-11-11 2019-08-06 Medtronic, Inc. Seizure disorder evaluation based on intracranial pressure and patient motion
WO2010057063A2 (en) * 2008-11-13 2010-05-20 Proteus Biomedical, Inc. Pacing and stimulation system, device and method
US8644919B2 (en) 2008-11-13 2014-02-04 Proteus Digital Health, Inc. Shielded stimulation and sensing system and method
JP2012508624A (en) * 2008-11-13 2012-04-12 プロテウス バイオメディカル インコーポレイテッド Multiplexed multiple electrode nerve stimulator
NZ602416A (en) 2008-11-14 2014-08-29 Univ Leland Stanford Junior Optically-based stimulation of target cells and modifications thereto
US8442644B2 (en) 2008-11-18 2013-05-14 Greatbatch Ltd. Satellite therapy delivery system for brain neuromodulation
EP2358429A4 (en) * 2008-12-02 2013-05-29 Proteus Digital Health Inc Analyzer compatible communication protocol
WO2010075518A1 (en) * 2008-12-23 2010-07-01 Neurovista Corporation Brain state analysis based on select seizure onset characteristics and clinical manifestations
US8849390B2 (en) 2008-12-29 2014-09-30 Cyberonics, Inc. Processing for multi-channel signals
US8412336B2 (en) * 2008-12-29 2013-04-02 Autonomic Technologies, Inc. Integrated delivery and visualization tool for a neuromodulation system
US8588933B2 (en) * 2009-01-09 2013-11-19 Cyberonics, Inc. Medical lead termination sleeve for implantable medical devices
US8494641B2 (en) 2009-04-22 2013-07-23 Autonomic Technologies, Inc. Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism
US8849369B2 (en) * 2009-01-15 2014-09-30 Eic Laboratories Wireless recording and stimulation of brain activity
US9320908B2 (en) * 2009-01-15 2016-04-26 Autonomic Technologies, Inc. Approval per use implanted neurostimulator
US20100185249A1 (en) * 2009-01-22 2010-07-22 Wingeier Brett M Method and Devices for Adrenal Stimulation
US20100191304A1 (en) 2009-01-23 2010-07-29 Scott Timothy L Implantable Medical Device for Providing Chronic Condition Therapy and Acute Condition Therapy Using Vagus Nerve Stimulation
US8374703B2 (en) 2009-01-26 2013-02-12 Incube Labs, Llc Method and apparatus for the detection of aberrant neural-electric activity
ITRM20090027A1 (en) * 2009-01-26 2010-07-27 Alain Rocco STIMULATION SYSTEM FOR PAIN TREATMENT AND ITS FUNCTIONING METHOD.
US8364254B2 (en) * 2009-01-28 2013-01-29 Brainscope Company, Inc. Method and device for probabilistic objective assessment of brain function
US8655438B2 (en) * 2009-02-25 2014-02-18 Dartmouth College Electroencephalography monitoring device having a self-adaptive analog-to-digital converter
US9492680B2 (en) * 2009-03-06 2016-11-15 Neuralieve Method and apparatus to record and analyze TMS treatments and results
US8774923B2 (en) * 2009-03-22 2014-07-08 Sorin Crm Sas Optimal deep brain stimulation therapy with Q learning
WO2010115139A2 (en) * 2009-04-02 2010-10-07 Proteus Biomedical, Inc. Method and apparatus for implantable lead
US8827912B2 (en) 2009-04-24 2014-09-09 Cyberonics, Inc. Methods and systems for detecting epileptic events using NNXX, optionally with nonlinear analysis parameters
US8239028B2 (en) * 2009-04-24 2012-08-07 Cyberonics, Inc. Use of cardiac parameters in methods and systems for treating a chronic medical condition
US20100280336A1 (en) * 2009-04-30 2010-11-04 Medtronic, Inc. Anxiety disorder monitoring
WO2010138332A1 (en) 2009-05-27 2010-12-02 Cardiac Pacemakers, Inc. Adaptive event storage in an implantable device
US8786624B2 (en) 2009-06-02 2014-07-22 Cyberonics, Inc. Processing for multi-channel signals
CN102802725B (en) * 2009-06-17 2015-12-09 内克斯蒂姆股份公司 Magnetic stimulation device and method
US20110015537A1 (en) * 2009-07-15 2011-01-20 General Electric Company Method, apparatus and computer program for monitoring specific cerebral activity
WO2011011736A2 (en) 2009-07-23 2011-01-27 Proteus Biomedical, Inc. Solid-state thin film capacitor
EP2459276B1 (en) * 2009-07-30 2016-11-09 Medtronic Bakken Research Center B.V. System for deep brain stimulation
US20110028859A1 (en) * 2009-07-31 2011-02-03 Neuropace, Inc. Methods, Systems and Devices for Monitoring a Target in a Neural System and Facilitating or Controlling a Cell Therapy
US10321840B2 (en) * 2009-08-14 2019-06-18 Brainscope Company, Inc. Development of fully-automated classifier builders for neurodiagnostic applications
CA2772330A1 (en) 2009-08-27 2011-03-03 The Cleveland Clinic Foundation System and method to estimate region of tissue activation
US8460356B2 (en) 2009-12-18 2013-06-11 Scion Neurostim, Llc Devices and methods for vestibular and/or cranial nerve stimulation
WO2012082960A2 (en) 2010-12-14 2012-06-21 The Regents Of The University Of California Devices, systems and methods for the treatment of medical disorders
KR20170127057A (en) 2009-10-05 2017-11-20 더 리젠트스 오브 더 유니이버시티 오브 캘리포니아 Extracranial implantable devices, systems and methods for the treatment of neurological disorders
US20110087125A1 (en) * 2009-10-09 2011-04-14 Elvir Causevic System and method for pain monitoring at the point-of-care
RU2012120108A (en) * 2009-10-16 2013-11-27 Сапиенс Стиринг Брейн Стимьюлейшн Б.В. NEURO INTERFACE SYSTEM
US9770204B2 (en) 2009-11-11 2017-09-26 Medtronic, Inc. Deep brain stimulation for sleep and movement disorders
US20110125078A1 (en) * 2009-11-25 2011-05-26 Medtronic, Inc. Optical stimulation therapy
WO2011066552A2 (en) * 2009-11-30 2011-06-03 University Of South Florida Cubic silicon carbide implantable neural prosthetic
WO2011068997A1 (en) 2009-12-02 2011-06-09 The Cleveland Clinic Foundation Reversing cognitive-motor impairments in patients having a neuro-degenerative disease using a computational modeling approach to deep brain stimulation programming
US20110144520A1 (en) * 2009-12-16 2011-06-16 Elvir Causevic Method and device for point-of-care neuro-assessment and treatment guidance
CN102791185A (en) 2009-12-21 2012-11-21 S·华 Insertion of medical devices through non-orthogonal and orthogonal trajectories within the cranium and methods of using
US20110219325A1 (en) * 2010-03-02 2011-09-08 Himes David M Displaying and Manipulating Brain Function Data Including Enhanced Data Scrolling Functionality
US20110218820A1 (en) * 2010-03-02 2011-09-08 Himes David M Displaying and Manipulating Brain Function Data Including Filtering of Annotations
CN102844427B (en) 2010-03-17 2016-07-06 小利兰·斯坦福大学托管委员会 Photo-sensitive ion permeability molecule
US9717439B2 (en) 2010-03-31 2017-08-01 Medtronic, Inc. Patient data display
EP2552536B1 (en) 2010-04-01 2016-06-08 Ecole Polytechnique Fédérale de Lausanne (EPFL) Device for interacting with neurological tissue
US8562536B2 (en) 2010-04-29 2013-10-22 Flint Hills Scientific, Llc Algorithm for detecting a seizure from cardiac data
US8649871B2 (en) 2010-04-29 2014-02-11 Cyberonics, Inc. Validity test adaptive constraint modification for cardiac data used for detection of state changes
US8831732B2 (en) 2010-04-29 2014-09-09 Cyberonics, Inc. Method, apparatus and system for validating and quantifying cardiac beat data quality
CN102247137B (en) * 2010-05-19 2013-06-19 中国科学院电子学研究所 Microelectrode array-based multichannel neural information detection system
CA2802708A1 (en) 2010-06-14 2011-12-22 Boston Scientific Neuromodulation Corporation Programming interface for spinal cord neuromodulation
US8679009B2 (en) 2010-06-15 2014-03-25 Flint Hills Scientific, Llc Systems approach to comorbidity assessment
US8641646B2 (en) 2010-07-30 2014-02-04 Cyberonics, Inc. Seizure detection using coordinate data
US9037224B1 (en) 2010-08-02 2015-05-19 Chi Yung Fu Apparatus for treating a patient
US9095266B1 (en) 2010-08-02 2015-08-04 Chi Yung Fu Method for treating a patient
US8690748B1 (en) * 2010-08-02 2014-04-08 Chi Yung Fu Apparatus for measurement and treatment of a patient
US9211411B2 (en) 2010-08-26 2015-12-15 Medtronic, Inc. Therapy for rapid eye movement behavior disorder (RBD)
US9155891B2 (en) 2010-09-20 2015-10-13 Neuropace, Inc. Current management system for a stimulation output stage of an implantable neurostimulation system
US9155861B2 (en) 2010-09-20 2015-10-13 Neuronexus Technologies, Inc. Neural drug delivery system with fluidic threads
US8684921B2 (en) 2010-10-01 2014-04-01 Flint Hills Scientific Llc Detecting, assessing and managing epilepsy using a multi-variate, metric-based classification analysis
US10226209B2 (en) 2010-10-15 2019-03-12 Brain Sentinel, Inc. Method and apparatus for classification of seizure type and severity using electromyography
PT2627244T (en) 2010-10-15 2018-10-30 Brain Sentinel Inc Apparatus with emg sensors for detecting seizures
US8718770B2 (en) 2010-10-21 2014-05-06 Medtronic, Inc. Capture threshold measurement for selection of pacing vector
CN106947741A (en) 2010-11-05 2017-07-14 斯坦福大学托管董事会 Photoactivation is fitted together to opsin and its application method
JP6328424B6 (en) 2010-11-05 2018-07-11 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー Control and characterization of memory functions
AU2011323237B2 (en) 2010-11-05 2015-11-12 The Board Of Trustees Of The Leland Stanford Junior University Optically-controlled CNS dysfunction
WO2012061744A2 (en) 2010-11-05 2012-05-10 The Board Of Trustees Of The Leland Stanford Junior University Stabilized step function opsin proteins and methods of using the same
CN106422081B (en) 2010-11-05 2019-06-21 斯坦福大学托管董事会 The upper conversion of light for light genetic method
JP6355335B2 (en) 2010-11-05 2018-07-11 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー Optogenetic control of reward-related behavior
JP5746206B2 (en) * 2010-11-09 2015-07-08 国立大学法人大阪大学 Implantable device
US8696722B2 (en) 2010-11-22 2014-04-15 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic magnetic resonance imaging
WO2012075192A2 (en) 2010-11-30 2012-06-07 The Regents Of The University Of California Pulse generator for cranial nerve stimulation
JP6559395B2 (en) 2010-12-14 2019-08-14 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Extracranial implantable system for the treatment of medical disorders
AU2011343589B2 (en) 2010-12-16 2017-02-23 Scion NeuroStim, Inc. Systems, methods and apparatus for delivering nerve stimulation to a patient with physician oversight
WO2012094621A2 (en) * 2011-01-06 2012-07-12 The Johns Hopkins University Seizure detection device and systems
US9504390B2 (en) 2011-03-04 2016-11-29 Globalfoundries Inc. Detecting, assessing and managing a risk of death in epilepsy
CA2828318A1 (en) 2011-03-29 2012-10-04 Boston Scientific Neuromodulation Corporation System and method for image registration
ITRM20110206A1 (en) * 2011-04-21 2012-10-22 Ab Medica Spa ACQUISITION AND MONITORING SYSTEM OF BIOELECTRIC SIGNALS FROM THE BRAIN AND INTRACRANIC STIMULATION.
US9498162B2 (en) 2011-04-25 2016-11-22 Cyberonics, Inc. Identifying seizures using heart data from two or more windows
US9402550B2 (en) 2011-04-29 2016-08-02 Cybertronics, Inc. Dynamic heart rate threshold for neurological event detection
EP2704793B1 (en) 2011-05-04 2019-07-17 Ramot at Tel Aviv University, Ltd. Regulation of amyloid beta molecular composition for the treatment of alzheimer's disease
US8355784B2 (en) 2011-05-13 2013-01-15 Medtronic, Inc. Dynamic representation of multipolar leads in a programmer interface
US9592389B2 (en) 2011-05-27 2017-03-14 Boston Scientific Neuromodulation Corporation Visualization of relevant stimulation leadwire electrodes relative to selected stimulation information
WO2012167096A2 (en) 2011-06-03 2012-12-06 The Board Of Trustees Of The University Of Illinois Conformable actively multiplexed high-density surface electrode array for brain interfacing
EP2729063A4 (en) 2011-07-05 2015-03-18 Lgch Inc Method and apparatus for detecting seizures
WO2013023085A2 (en) 2011-08-09 2013-02-14 Boston Scientific Neuromodulation Corporation Systems and methods for stimulation-related volume analysis, creation, and sharing
TWI442905B (en) * 2011-09-30 2014-07-01 Univ Nat Chiao Tung Apparatus for locating the target of the stimulation
US9549677B2 (en) 2011-10-14 2017-01-24 Flint Hills Scientific, L.L.C. Seizure detection methods, apparatus, and systems using a wavelet transform maximum modulus algorithm
US8959082B2 (en) 2011-10-31 2015-02-17 Elwha Llc Context-sensitive query enrichment
US10220144B2 (en) 2011-11-21 2019-03-05 Incube Labs, Llc Apparatus, systems and methods for the treatment of neurological conditions
WO2013090356A2 (en) 2011-12-16 2013-06-20 The Board Of Trustees Of The Leland Stanford Junior University Opsin polypeptides and methods of use thereof
ES2728077T3 (en) 2012-02-21 2019-10-22 Univ Leland Stanford Junior Compositions for the treatment of neurogenic disorders of the pelvic floor
US10448839B2 (en) 2012-04-23 2019-10-22 Livanova Usa, Inc. Methods, systems and apparatuses for detecting increased risk of sudden death
US9681836B2 (en) 2012-04-23 2017-06-20 Cyberonics, Inc. Methods, systems and apparatuses for detecting seizure and non-seizure states
US10542903B2 (en) * 2012-06-07 2020-01-28 Masimo Corporation Depth of consciousness monitor
US9604067B2 (en) 2012-08-04 2017-03-28 Boston Scientific Neuromodulation Corporation Techniques and methods for storing and transferring registration, atlas, and lead information between medical devices
EP2890454B1 (en) 2012-08-28 2017-11-08 Boston Scientific Neuromodulation Corporation Point-and-click programming for deep brain stimulation using real-time monopolar review trendlines
US9345884B2 (en) 2012-09-28 2016-05-24 Neuropace, Inc. Methods and systems for controlling a state of a neurostimulator
BR112015007002B1 (en) 2012-09-28 2022-10-18 The Regents Of The University Of California METHOD AND SYSTEM FOR PROVIDING COGNITIVE OR SENSORY ASSESSMENT OF AN INDIVIDUAL
US8583238B1 (en) 2012-10-02 2013-11-12 Great Lakes Neuro Technologies Inc. Wearable, unsupervised transcranial direct current stimulation (tDCS) device for movement disorder therapy, and method of using
JP6454944B2 (en) 2012-10-12 2019-01-23 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Configuration and spatial arrangement of front electrode sensor for detecting physiological signals
US9792412B2 (en) 2012-11-01 2017-10-17 Boston Scientific Neuromodulation Corporation Systems and methods for VOA model generation and use
CN104902806B (en) 2012-11-10 2019-06-04 加利福尼亚大学董事会 The assessment system and method for europathology
BR112015017042B1 (en) 2013-01-21 2022-03-03 Cala Health, Inc Device to treat tremor
US10220211B2 (en) 2013-01-22 2019-03-05 Livanova Usa, Inc. Methods and systems to diagnose depression
USD728801S1 (en) 2013-03-08 2015-05-05 Brainscope Company, Inc. Electrode headset
US9427593B2 (en) 2013-03-12 2016-08-30 Neuropace, Inc. Measuring current during delivery of voltage regulated stimulation to a patient
US9837704B2 (en) 2013-03-14 2017-12-05 Neuropace, Inc. Anatomically compliant antenna for implantable medical device
WO2014144409A1 (en) 2013-03-15 2014-09-18 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic control of behavioral state
US9101771B2 (en) 2013-03-15 2015-08-11 Neuropace, Inc. System and method for optimizing energy use and delivered current in an implantable device
US9636380B2 (en) 2013-03-15 2017-05-02 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic control of inputs to the ventral tegmental area
US9439150B2 (en) 2013-03-15 2016-09-06 Medtronic, Inc. Control of spectral agressors in a physiological signal montoring device
US9521979B2 (en) 2013-03-15 2016-12-20 Medtronic, Inc. Control of spectral agressors in a physiological signal monitoring device
US9056195B2 (en) 2013-03-15 2015-06-16 Cyberonics, Inc. Optimization of cranial nerve stimulation to treat seizure disorderse during sleep
US10220092B2 (en) 2013-04-29 2019-03-05 The Board Of Trustees Of The Leland Stanford Junior University Devices, systems and methods for optogenetic modulation of action potentials in target cells
JP2016523125A (en) 2013-05-30 2016-08-08 グラハム エイチ． クリーシー Local nervous stimulation
US11229789B2 (en) 2013-05-30 2022-01-25 Neurostim Oab, Inc. Neuro activator with controller
US9427566B2 (en) 2013-08-14 2016-08-30 Syntilla Medical LLC Implantable neurostimulation lead for head pain
US9839777B2 (en) 2013-08-14 2017-12-12 Syntilla Medical LLC Implantable neurostimulation lead for head pain
US10307609B2 (en) 2013-08-14 2019-06-04 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for controlling pain
US9042991B2 (en) 2013-08-14 2015-05-26 Syntilla Medical LLC Implantable head mounted neurostimulation system for head pain
EP3042329A2 (en) * 2013-09-04 2016-07-13 Zero360, Inc. Processing system and method
US9498635B2 (en) 2013-10-16 2016-11-22 Syntilla Medical LLC Implantable head located radiofrequency coupled neurostimulation system for head pain
US10960215B2 (en) 2013-10-23 2021-03-30 Nuxcel, Inc. Low profile head-located neurostimulator and method of fabrication
US10258805B2 (en) 2013-10-23 2019-04-16 Syntilla Medical, Llc Surgical method for implantable head mounted neurostimulation system for head pain
US9675796B2 (en) 2013-11-10 2017-06-13 Brainsgate Ltd. Implant and delivery system for neural stimulator
SG11201607799SA (en) 2014-03-18 2016-10-28 Fisher & Paykel Healthcare Ltd Medical data management system
US9585611B2 (en) 2014-04-25 2017-03-07 Cyberonics, Inc. Detecting seizures based on heartbeat data
US9302109B2 (en) 2014-04-25 2016-04-05 Cyberonics, Inc. Cranial nerve stimulation to treat depression during sleep
US10231621B2 (en) * 2014-05-05 2019-03-19 Neuropace, Inc. Use of a progressive compression encoding of physiologic waveform data in an implantable device to support discontinuing transmission of low-value data
JP6606105B2 (en) 2014-06-02 2019-11-13 カラ ヘルス，インコーポレイテッド System and method for peripheral nerve stimulation for treating tremor
US9959388B2 (en) 2014-07-24 2018-05-01 Boston Scientific Neuromodulation Corporation Systems, devices, and methods for providing electrical stimulation therapy feedback
US10265528B2 (en) 2014-07-30 2019-04-23 Boston Scientific Neuromodulation Corporation Systems and methods for electrical stimulation-related patient population volume analysis and use
US10272247B2 (en) 2014-07-30 2019-04-30 Boston Scientific Neuromodulation Corporation Systems and methods for stimulation-related volume analysis, creation, and sharing with integrated surgical planning and stimulation programming
CN107073258B (en) 2014-08-15 2020-02-21 艾克索尼克斯调制技术股份有限公司 System and method for neural stimulation electrode configuration based on neural localization
CN107073257B (en) 2014-08-15 2020-04-10 艾克索尼克斯调制技术股份有限公司 EMG lead positioning and stimulation titration in a neurostimulation system for treating overactive bladder
EP3180075A4 (en) 2014-08-15 2018-03-07 Axonics Modulation Technologies Inc. Integrated electromyographic clinician programmer for use with an implantable neurostimulator
US9924904B2 (en) 2014-09-02 2018-03-27 Medtronic, Inc. Power-efficient chopper amplifier
US9974959B2 (en) 2014-10-07 2018-05-22 Boston Scientific Neuromodulation Corporation Systems, devices, and methods for electrical stimulation using feedback to adjust stimulation parameters
US10028694B2 (en) 2014-11-25 2018-07-24 Scienceplusplease, Llc Non-invasive systems and methods to detect cortical spreading depression for the detection and assessment of brain injury and concussion
US10130813B2 (en) 2015-02-10 2018-11-20 Neuropace, Inc. Seizure onset classification and stimulation parameter selection
EP3777964A1 (en) 2015-02-16 2021-02-17 Newronika S.p.A. Apparatus for treating neurological disorders
USD765259S1 (en) 2015-02-19 2016-08-30 Brainscope Company, Inc. Ear attachment for medical headset
US11077301B2 (en) 2015-02-21 2021-08-03 NeurostimOAB, Inc. Topical nerve stimulator and sensor for bladder control
US10327984B2 (en) 2015-03-27 2019-06-25 Equility Llc Controlling ear stimulation in response to image analysis
US11364380B2 (en) 2015-03-27 2022-06-21 Elwha Llc Nerve stimulation system, subsystem, headset, and earpiece
US10512783B2 (en) 2015-03-27 2019-12-24 Equility Llc User interface method and system for ear stimulation
US10039928B2 (en) 2015-03-27 2018-08-07 Equility Llc Ear stimulation with neural feedback sensing
US10406376B2 (en) 2015-03-27 2019-09-10 Equility Llc Multi-factor control of ear stimulation
US10589105B2 (en) 2015-03-27 2020-03-17 The Invention Science Fund Ii, Llc Method and system for controlling ear stimulation
US10398902B2 (en) 2015-03-27 2019-09-03 Equility Llc Neural stimulation method and system with audio output
US9987489B2 (en) 2015-03-27 2018-06-05 Elwha Llc Controlling ear stimulation in response to electrical contact sensing
WO2016172243A1 (en) 2015-04-21 2016-10-27 Cyberonics, Inc. Evaluation of efficacy of epilepsy therapy
EP3093043B1 (en) 2015-05-13 2018-11-14 Brainsgate Ltd. Implant and delivery system for neural stimulator
US10780283B2 (en) 2015-05-26 2020-09-22 Boston Scientific Neuromodulation Corporation Systems and methods for analyzing electrical stimulation and selecting or manipulating volumes of activation
AU2016268259B2 (en) 2015-05-26 2019-01-31 Boston Scientific Neuromodulation Corporation Systems and methods for analyzing electrical stimulation and selecting or manipulating volumes of activation
CN107847730B (en) 2015-06-10 2021-03-16 卡拉健康公司 System and method for peripheral nerve stimulation to treat tremor with a detachable treatment and monitoring unit
US10568516B2 (en) 2015-06-22 2020-02-25 The Board Of Trustees Of The Leland Stanford Junior University Methods and devices for imaging and/or optogenetic control of light-responsive neurons
WO2017003947A1 (en) 2015-06-29 2017-01-05 Boston Scientific Neuromodulation Corporation Systems and methods for selecting stimulation parameters by targeting and steering
EP3280490B1 (en) 2015-06-29 2021-09-01 Boston Scientific Neuromodulation Corporation Systems for selecting stimulation parameters based on stimulation target region, effects, or side effects
US10232169B2 (en) 2015-07-23 2019-03-19 Boston Scientific Neuromodulation Corporation Burr hole plugs for electrical stimulation systems and methods of making and using
US10729352B2 (en) 2015-08-17 2020-08-04 Neuropace, Inc. Neurological event detection tools for implantable medical devices
US11058541B2 (en) 2015-09-04 2021-07-13 The Johns Hopkins University Low-profile intercranial device
CN108348746B (en) 2015-09-23 2021-10-12 卡拉健康公司 System and method for peripheral nerve stimulation in fingers or hands to treat hand tremor
WO2017062378A1 (en) 2015-10-09 2017-04-13 Boston Scientific Neuromodulation Corporation System and methods for clinical effects mapping for directional stimulations leads
US9717917B2 (en) 2016-01-06 2017-08-01 Syntilla Medical LLC Charging system incorporating independent charging and communication with multiple implanted devices
US11344722B2 (en) 2016-01-21 2022-05-31 Cala Health, Inc. Systems, methods and devices for peripheral neuromodulation for treating diseases related to overactive bladder
US10786674B2 (en) * 2016-03-08 2020-09-29 Medtronic, Inc. Medical therapy target definition
BR112018071375A2 (en) 2016-04-19 2019-02-05 Brain Sentinel Inc systems and methods for the characterization of seizures
US10716942B2 (en) 2016-04-25 2020-07-21 Boston Scientific Neuromodulation Corporation System and methods for directional steering of electrical stimulation
US10776456B2 (en) 2016-06-24 2020-09-15 Boston Scientific Neuromodulation Corporation Systems and methods for visual analytics of clinical effects
IL264116B2 (en) 2016-07-08 2024-01-01 Cala Health Inc Systems and methods for stimulating n nerves with exactly n electrodes and improved dry electrodes
WO2018013884A1 (en) 2016-07-15 2018-01-18 Cortera Neurotechnologies, Inc. Neuromodulation apparatus, method and system
US10912648B2 (en) 2016-08-30 2021-02-09 Longeviti Neuro Solutions Llc Method for manufacturing a low-profile intercranial device and the low-profile intercranial device manufactured thereby
WO2018044881A1 (en) 2016-09-02 2018-03-08 Boston Scientific Neuromodulation Corporation Systems and methods for visualizing and directing stimulation of neural elements
US10780282B2 (en) 2016-09-20 2020-09-22 Boston Scientific Neuromodulation Corporation Systems and methods for steering electrical stimulation of patient tissue and determining stimulation parameters
CN109803719B (en) 2016-10-14 2023-05-26 波士顿科学神经调制公司 System and method for closed loop determination of stimulation parameter settings for an electrical simulation system
WO2018072894A1 (en) 2016-10-19 2018-04-26 Precisis Ag Methods and devices for the electrical stimulation of brain tissue via electrodes within cranial bone
US11191959B2 (en) 2016-12-12 2021-12-07 Cogniguard Medical Holdings Limited Monitoring and treatment system for neurological disorders
JP6834005B2 (en) 2017-01-03 2021-02-24 ボストン サイエンティフィック ニューロモデュレイション コーポレイション Systems and methods for selecting MRI-matched stimulus parameters
EP3519043B1 (en) 2017-01-10 2020-08-12 Boston Scientific Neuromodulation Corporation Systems and methods for creating stimulation programs based on user-defined areas or volumes
US10939867B2 (en) * 2017-03-10 2021-03-09 Robert S. Bray Paralysis monitoring system
US10625082B2 (en) 2017-03-15 2020-04-21 Boston Scientific Neuromodulation Corporation Visualization of deep brain stimulation efficacy
US11294165B2 (en) 2017-03-30 2022-04-05 The Board Of Trustees Of The Leland Stanford Junior University Modular, electro-optical device for increasing the imaging field of view using time-sequential capture
CA3058786A1 (en) 2017-04-03 2018-10-11 Cala Health, Inc. Systems, methods and devices for peripheral neuromodulation for treating diseases related to overactive bladder
WO2018187090A1 (en) 2017-04-03 2018-10-11 Boston Scientific Neuromodulation Corporation Systems and methods for estimating a volume of activation using a compressed database of threshold values
EP3651849B1 (en) 2017-07-14 2023-05-31 Boston Scientific Neuromodulation Corporation Estimating clinical effects of electrical stimulation
US11172868B2 (en) * 2017-07-21 2021-11-16 Yi Zheng Screening of malignant glioma, brain tumors, and brain injuries using disturbance coefficient, differential impedances, and artificial neural network
US10512555B2 (en) * 2017-08-03 2019-12-24 Sam Emmanuel JOHN Medical device for sensing and or stimulating tissue
US10960214B2 (en) 2017-08-15 2021-03-30 Boston Scientific Neuromodulation Corporation Systems and methods for controlling electrical stimulation using multiple stimulation fields
US10729907B2 (en) 2017-10-20 2020-08-04 Neuropace, Inc. Systems and methods for clinical decision making for a patient receiving a neuromodulation therapy based on deep learning
WO2019094365A1 (en) 2017-11-07 2019-05-16 Neurostim Oab, Inc. Non-invasive nerve activator with adaptive circuit
EP3710105B1 (en) 2017-11-13 2023-10-04 Boston Scientific Neuromodulation Corporation Systems for making and using a low-profile control module for an electrical stimulation system
DK3499914T3 (en) * 2017-12-13 2020-12-14 Oticon As Høreapparatsystem
US11589992B2 (en) 2018-01-09 2023-02-28 Longeviti Neuro Solutions Llc Universal low-profile intercranial assembly
WO2019143574A1 (en) 2018-01-16 2019-07-25 Boston Scientific Neuromodulation Corporation An electrical stimulation system with a case-neutral battery and a control module for such a system
EP3740274A4 (en) 2018-01-17 2021-10-27 Cala Health, Inc. Systems and methods for treating inflammatory bowel disease through peripheral nerve stimulation
IT201800002962A1 (en) 2018-02-22 2019-08-22 Newronika Srl APPARATUS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS USING ELECTROSTIMULATION AND METHOD OF PROCESSING THE NEUROLOGICAL SIGNAL COLLECTED BY THIS APP
EP3762087B1 (en) 2018-03-09 2023-04-26 Boston Scientific Neuromodulation Corporation Burr hole plugs for electrical stimulation systems
WO2019178145A1 (en) 2018-03-16 2019-09-19 Boston Scientific Neuromodulation Corporation Kits and methods for securing a burr hole plugs for stimulation systems
US10258284B1 (en) 2018-04-05 2019-04-16 Tufts Medical Center, Inc. Implant in middle meningial-artery
WO2019210214A1 (en) 2018-04-27 2019-10-31 Boston Scientific Neuromodulation Corporation Systems for visualizing and programming electrical stimulation
EP3784331B1 (en) 2018-04-27 2023-01-18 Boston Scientific Neuromodulation Corporation Multi-mode electrical stimulation systems and methods of making and using
CN111195189A (en) * 2018-11-17 2020-05-26 中国科学院宁波工业技术研究院慈溪生物医学工程研究所 Gait freezing symptom rehabilitation training method and system for Parkinson patient
US11318309B2 (en) 2018-12-13 2022-05-03 Newronika S.P.A. Method and apparatus for treating Tourette Syndrome by brain stimulation
US11481578B2 (en) 2019-02-22 2022-10-25 Neuropace, Inc. Systems and methods for labeling large datasets of physiological records based on unsupervised machine learning
US11612750B2 (en) 2019-03-19 2023-03-28 Neuropace, Inc. Methods and systems for optimizing therapy using stimulation mimicking natural seizures
US11160580B2 (en) 2019-04-24 2021-11-02 Spine23 Inc. Systems and methods for pedicle screw stabilization of spinal vertebrae
US11093038B2 (en) 2019-05-14 2021-08-17 Synchron Australia Pty Limited Systems and methods for generic control using a neural signal
US11848090B2 (en) 2019-05-24 2023-12-19 Axonics, Inc. Trainer for a neurostimulator programmer and associated methods of use with a neurostimulation system
US11439829B2 (en) 2019-05-24 2022-09-13 Axonics, Inc. Clinician programmer methods and systems for maintaining target operating temperatures
US11623095B2 (en) 2019-06-20 2023-04-11 Boston Scientific Neuromodulation Corporation Methods and systems for interleaving waveforms for electrical stimulation and measurement
EP3990100A4 (en) 2019-06-26 2023-07-19 Neurostim Technologies LLC Non-invasive nerve activator with adaptive circuit
US20220300434A1 (en) * 2019-07-26 2022-09-22 Boston Scientific Neuromodulation Corporation Methods and systems for storage, retrieval, and visualization of signals and signal features
US11890468B1 (en) 2019-10-03 2024-02-06 Cala Health, Inc. Neurostimulation systems with event pattern detection and classification
WO2021086972A1 (en) 2019-10-29 2021-05-06 Synchron Australia Pty Limited Systems and methods for configuring a brain control interface using data from deployed systems
JP2023506713A (en) 2019-12-16 2023-02-20 ニューロスティム テクノロジーズ エルエルシー Noninvasive nerve activator using booster charge delivery
ES2936329T3 (en) * 2020-01-09 2023-03-16 Synergia Medical Active implantable stimulation device for on-demand stimulation of a vagus nerve
CN111544289A (en) * 2020-05-13 2020-08-18 江苏师范大学 Intelligent eye physiotherapy equipment with electroencephalogram feedback
RU2753267C1 (en) * 2020-06-05 2021-08-12 ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "СберМедИИ" Method for detecting focal epileptiform discharges in long-term eeg recording
CN112774037A (en) * 2021-02-05 2021-05-11 杭州诺为医疗技术有限公司 Data transmission method and system in implantable closed-loop self-response system
WO2022251234A1 (en) * 2021-05-24 2022-12-01 The Regents Of The University Of California Memory enhancement by prefrontal deep brain stimulation synchronized to medial temporal lobe during sleep
GR1010577B (en) * 2023-03-03 2023-11-22 Βασιλειος Νικολαου Κοκκινος Long-term intracranial stereoelectroencephalography system

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3032029A (en) * 1958-07-09 1962-05-01 Thompson Ramo Wooldridge Inc System controlling apparatus and method
US3850161A (en) 1973-04-09 1974-11-26 S Liss Method and apparatus for monitoring and counteracting excess brain electrical energy to prevent epileptic seizures and the like
US3918461A (en) * 1974-01-31 1975-11-11 Irving S Cooper Method for electrically stimulating the human brain
US4019518A (en) 1975-08-11 1977-04-26 Medtronic, Inc. Electrical stimulation system
US4223678A (en) * 1978-05-03 1980-09-23 Mieczyslaw Mirowski Arrhythmia recorder for use with an implantable defibrillator
US4373527B1 (en) 1979-04-27 1995-06-27 Univ Johns Hopkins Implantable programmable medication infusion system
US4295474A (en) * 1979-10-02 1981-10-20 The Johns Hopkins University Recorder with patient alarm and service request systems suitable for use with automatic implantable defibrillator
JPS57177735A (en) * 1981-04-27 1982-11-01 Toyoda Chuo Kenkyusho Kk Telemeter type brain nanometer
US4566464A (en) * 1981-07-27 1986-01-28 Piccone Vincent A Implantable epilepsy monitor apparatus
US4702254A (en) * 1983-09-14 1987-10-27 Jacob Zabara Neurocybernetic prosthesis
US4867164A (en) * 1983-09-14 1989-09-19 Jacob Zabara Neurocybernetic prosthesis
US5025807A (en) * 1983-09-14 1991-06-25 Jacob Zabara Neurocybernetic prosthesis
US4581758A (en) 1983-11-04 1986-04-08 At&T Bell Laboratories Acoustic direction identification system
US4844075A (en) * 1984-01-09 1989-07-04 Pain Suppression Labs, Inc. Transcranial stimulation for the treatment of cerebral palsy
US4878498A (en) * 1988-10-14 1989-11-07 Somatics, Inc. Electroconvulsive therapy apparatus and method for automatic monitoring of patient seizures
US4873981A (en) * 1988-10-14 1989-10-17 Somatics, Inc. Electroconvulsive therapy apparatus and method for automatic monitoring of patient seizures
US5269303A (en) * 1991-02-22 1993-12-14 Cyberonics, Inc. Treatment of dementia by nerve stimulation
US5222503A (en) * 1991-04-24 1993-06-29 Beth Israel Hospital Association Ambulatory electroencephalography system
US5335657A (en) * 1991-05-03 1994-08-09 Cyberonics, Inc. Therapeutic treatment of sleep disorder by nerve stimulation
US5299569A (en) * 1991-05-03 1994-04-05 Cyberonics, Inc. Treatment of neuropsychiatric disorders by nerve stimulation
US5269302A (en) * 1991-05-10 1993-12-14 Somatics, Inc. Electroconvulsive therapy apparatus and method for monitoring patient seizures
US5304206A (en) * 1991-11-18 1994-04-19 Cyberonics, Inc. Activation techniques for implantable medical device
EP0743839A4 (en) * 1994-02-09 1999-02-10 Univ Iowa Res Found Human cerebral cortex neural prosthetic
US5540734A (en) * 1994-09-28 1996-07-30 Zabara; Jacob Cranial nerve stimulation treatments using neurocybernetic prosthesis
US5626627A (en) * 1995-07-27 1997-05-06 Duke University Electroconvulsive therapy method using ICTAL EEG data as an indicator of ECT seizure adequacy
US5995868A (en) * 1996-01-23 1999-11-30 University Of Kansas System for the prediction, rapid detection, warning, prevention, or control of changes in activity states in the brain of a subject
US5743860A (en) * 1996-03-20 1998-04-28 Lockheed Martin Energy Systems, Inc. Apparatus and method for epileptic seizure detection using non-linear techniques
US5683422A (en) * 1996-04-25 1997-11-04 Medtronic, Inc. Method and apparatus for treating neurodegenerative disorders by electrical brain stimulation
US5782798A (en) * 1996-06-26 1998-07-21 Medtronic, Inc. Techniques for treating eating disorders by brain stimulation and drug infusion
US6016449A (en) * 1997-10-27 2000-01-18 Neuropace, Inc. System for treatment of neurological disorders

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7747325B2 (en) 1998-08-05 2010-06-29 Neurovista Corporation Systems and methods for monitoring a patient's neurological disease state
US7853329B2 (en) 1998-08-05 2010-12-14 Neurovista Corporation Monitoring efficacy of neural modulation therapy
US7930035B2 (en) 1998-08-05 2011-04-19 Neurovista Corporation Providing output indicative of subject's disease state
US7676263B2 (en) 2006-06-23 2010-03-09 Neurovista Corporation Minimally invasive system for selecting patient-specific therapy parameters
US8295934B2 (en) 2006-11-14 2012-10-23 Neurovista Corporation Systems and methods of reducing artifact in neurological stimulation systems
US9622675B2 (en) 2007-01-25 2017-04-18 Cyberonics, Inc. Communication error alerting in an epilepsy monitoring system
US9898656B2 (en) 2007-01-25 2018-02-20 Cyberonics, Inc. Systems and methods for identifying a contra-ictal condition in a subject
US8036736B2 (en) 2007-03-21 2011-10-11 Neuro Vista Corporation Implantable systems and methods for identifying a contra-ictal condition in a subject
US9788744B2 (en) 2007-07-27 2017-10-17 Cyberonics, Inc. Systems for monitoring brain activity and patient advisory device
US9643019B2 (en) 2010-02-12 2017-05-09 Cyberonics, Inc. Neurological monitoring and alerts

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US20020002390A1 (en) 2002-01-03

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