CA2255599A1 - Light-controlled electrokinetic assembly of particles near surfaces - Google Patents

Light-controlled electrokinetic assembly of particles near surfaces

Info

Publication number
CA2255599A1
CA2255599A1 CA002255599A CA2255599A CA2255599A1 CA 2255599 A1 CA2255599 A1 CA 2255599A1 CA 002255599 A CA002255599 A CA 002255599A CA 2255599 A CA2255599 A CA 2255599A CA 2255599 A1 CA2255599 A1 CA 2255599A1
Authority
CA
Canada
Prior art keywords
assembly
present
biomolecules
manipulation
light
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002255599A
Other languages
French (fr)
Other versions
CA2255599C (en
Inventor
Michael Seul
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioarray Solutions Ltd
Original Assignee
Bioarray Solutions, Llc
Michael Seul
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21778189&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2255599(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bioarray Solutions, Llc, Michael Seul filed Critical Bioarray Solutions, Llc
Priority to CA2548805A priority Critical patent/CA2548805C/en
Publication of CA2255599A1 publication Critical patent/CA2255599A1/en
Application granted granted Critical
Publication of CA2255599C publication Critical patent/CA2255599C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6825Nucleic acid detection involving sensors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6834Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54386Analytical elements
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845Methods of identifying protein-protein interactions in protein mixtures
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B3/00Simple or compound lenses
    • G02B3/0006Arrays
    • G02B3/0012Arrays characterised by the manufacturing method
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B3/00Simple or compound lenses
    • G02B3/0006Arrays
    • G02B3/0037Arrays characterized by the distribution or form of lenses
    • G02B3/0056Arrays characterized by the distribution or form of lenses arranged along two different directions in a plane, e.g. honeycomb arrangement of lenses
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B3/00Simple or compound lenses
    • G02B3/0006Arrays
    • G02B3/0075Arrays characterized by non-optical structures, e.g. having integrated holding or alignment means
    • HELECTRICITY
    • H05ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05HPLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H3/00Production or acceleration of neutral particle beams, e.g. molecular or atomic beams
    • H05H3/04Acceleration by electromagnetic wave pressure
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00585Parallel processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00596Solid-phase processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00646Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports
    • B01J2219/00648Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports by the use of solid beads
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00653Making arrays on substantially continuous surfaces the compounds being bound to electrodes embedded in or on the solid supports
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00659Two-dimensional arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00709Type of synthesis
    • B01J2219/00713Electrochemical synthesis
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0647Handling flowable solids, e.g. microscopic beads, cells, particles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0647Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652Sorting or classification of particles or molecules
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0647Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0663Stretching or orienting elongated molecules or particles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0647Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668Trapping microscopic beads
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0627Sensor or part of a sensor is integrated
    • B01L2300/0636Integrated biosensor, microarrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0816Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877Flow chambers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/089Virtual walls for guiding liquids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0427Electrowetting
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0454Moving fluids with specific forces or mechanical means specific forces radiation pressure, optical tweezers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Electro-optical investigation, e.g. flow cytometers
    • G01N15/1468Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle
    • G01N15/149
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Electro-optical investigation, e.g. flow cytometers
    • G01N2015/1497Particle shape
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/808Optical sensing apparatus
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/81Packaged device or kit
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/814Enzyme separation or purification
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/806Electrical property or magnetic property
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/807Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808Automated or kit
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/807Apparatus included in process claim, e.g. physical support structures
    • Y10S436/809Multifield plates or multicontainer arrays
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25125Digestion or removing interfering materials

Abstract

A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process;
and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components.
CA002255599A 1996-04-25 1997-04-24 Light-controlled electrokinetic assembly of particles near surfaces Expired - Lifetime CA2255599C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2548805A CA2548805C (en) 1996-04-25 1997-04-24 Light-controlled electrokinetic assembly of particles near surfaces

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1664296P 1996-04-25 1996-04-25
US60/016,642 1996-04-25
PCT/US1997/008159 WO1997040385A1 (en) 1996-04-25 1997-04-24 Light-controlled electrokinetic assembly of particles near surfaces

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2548805A Division CA2548805C (en) 1996-04-25 1997-04-24 Light-controlled electrokinetic assembly of particles near surfaces

Publications (2)

Publication Number Publication Date
CA2255599A1 true CA2255599A1 (en) 1997-10-30
CA2255599C CA2255599C (en) 2006-09-05

Family

ID=21778189

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002255599A Expired - Lifetime CA2255599C (en) 1996-04-25 1997-04-24 Light-controlled electrokinetic assembly of particles near surfaces

Country Status (8)

Country Link
US (17) US6251691B1 (en)
EP (2) EP0907889B1 (en)
JP (1) JP4034351B2 (en)
AT (1) ATE366418T1 (en)
CA (1) CA2255599C (en)
DE (1) DE69737883T2 (en)
ES (1) ES2288760T3 (en)
WO (1) WO1997040385A1 (en)

Families Citing this family (211)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6569382B1 (en) * 1991-11-07 2003-05-27 Nanogen, Inc. Methods apparatus for the electronic, homogeneous assembly and fabrication of devices
US6652808B1 (en) * 1991-11-07 2003-11-25 Nanotronics, Inc. Methods for the electronic assembly and fabrication of devices
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US6958245B2 (en) 1996-04-25 2005-10-25 Bioarray Solutions Ltd. Array cytometry
US6387707B1 (en) * 1996-04-25 2002-05-14 Bioarray Solutions Array Cytometry
ES2288760T3 (en) * 1996-04-25 2008-01-16 Bioarray Solutions Ltd. ELECTROCINETIC ASSEMBLY CONTROLLED BY LIGHT OF PARTICLES NEXT TO SURFACES.
US6706473B1 (en) * 1996-12-06 2004-03-16 Nanogen, Inc. Systems and devices for photoelectrophoretic transport and hybridization of oligonucleotides
US6700550B2 (en) 1997-01-16 2004-03-02 Ambit Corporation Optical antenna array for harmonic generation, mixing and signal amplification
US6023540A (en) 1997-03-14 2000-02-08 Trustees Of Tufts College Fiber optic sensor with encoded microspheres
US20030027126A1 (en) 1997-03-14 2003-02-06 Walt David R. Methods for detecting target analytes and enzymatic reactions
US7622294B2 (en) 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
US6406845B1 (en) 1997-05-05 2002-06-18 Trustees Of Tuft College Fiber optic biosensor for selectively detecting oligonucleotide species in a mixed fluid sample
EP1003904B1 (en) * 1997-05-23 2007-07-11 BioArray Solutions Ltd. Color-encoding and in-situ interrogation of matrix-coupled chemical compounds
EP0985142A4 (en) * 1997-05-23 2006-09-13 Lynx Therapeutics Inc System and apparaus for sequential processing of analytes
DE19741716A1 (en) * 1997-09-22 1999-03-25 Hoechst Ag Recognition system
US7348181B2 (en) 1997-10-06 2008-03-25 Trustees Of Tufts College Self-encoding sensor with microspheres
US7115884B1 (en) 1997-10-06 2006-10-03 Trustees Of Tufts College Self-encoding fiber optic sensor
US6210910B1 (en) 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities
US6139831A (en) * 1998-05-28 2000-10-31 The Rockfeller University Apparatus and method for immobilizing molecules onto a substrate
EP1090293B2 (en) 1998-06-24 2019-01-23 Illumina, Inc. Decoding of array sensors with microspheres
US6203985B1 (en) * 1998-09-08 2001-03-20 Motorola, Inc. Bio-molecule analyzer with photosensitive material and fabrication
US6429027B1 (en) * 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
US6846460B1 (en) 1999-01-29 2005-01-25 Illumina, Inc. Apparatus and method for separation of liquid phases of different density and for fluorous phase organic syntheses
US20030207249A1 (en) * 1999-04-15 2003-11-06 Beske Oren E. Connection of cells to substrates using association pairs
US20030129654A1 (en) * 1999-04-15 2003-07-10 Ilya Ravkin Coded particles for multiplexed analysis of biological samples
US6908737B2 (en) * 1999-04-15 2005-06-21 Vitra Bioscience, Inc. Systems and methods of conducting multiplexed experiments
US20030166015A1 (en) * 1999-04-15 2003-09-04 Zarowitz Michael A. Multiplexed analysis of cell-substrate interactions
WO2000063419A1 (en) * 1999-04-15 2000-10-26 Virtual Arrays, Inc. Combinatorial chemical library supports having indicia at coding positions and methods of use
US20030134330A1 (en) * 1999-04-15 2003-07-17 Ilya Ravkin Chemical-library composition and method
US7253435B2 (en) * 1999-04-15 2007-08-07 Millipore Corporation Particles with light-polarizing codes
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US6355431B1 (en) 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
US6573491B1 (en) * 1999-05-17 2003-06-03 Rock Mountain Biosystems, Inc. Electromagnetic energy driven separation methods
US6942776B2 (en) * 1999-05-18 2005-09-13 Silicon Biosystems S.R.L. Method and apparatus for the manipulation of particles by means of dielectrophoresis
EP1190100B1 (en) 1999-05-20 2012-07-25 Illumina, Inc. Combinatorial decoding of random nucleic acid arrays
US6544732B1 (en) 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
US8481268B2 (en) 1999-05-21 2013-07-09 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US8080380B2 (en) 1999-05-21 2011-12-20 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
DK1218545T3 (en) 1999-08-18 2012-02-20 Illumina Inc Methods of Preparation of Oligonucleotide Solutions
AU2246601A (en) 1999-08-30 2001-04-10 Illumina, Inc. Methods for improving signal detection from an array
EP1226571A4 (en) 1999-09-17 2003-01-29 Bioarray Solutions Llc System and method for programmable illumination pattern generation
US7198702B1 (en) * 1999-09-30 2007-04-03 Wako Pure Chemical Industries, Ltd. Method for separating substances using dielectrophoretic forces
US20050069956A1 (en) * 1999-11-22 2005-03-31 Michael Seul Color-encoding and in-situ interrogation of matrix-coupled chemical compounds
US7427526B2 (en) 1999-12-20 2008-09-23 The Penn State Research Foundation Deposited thin films and their use in separation and sacrificial layer applications
US7361488B2 (en) 2000-02-07 2008-04-22 Illumina, Inc. Nucleic acid detection methods using universal priming
EP1990428B1 (en) 2000-02-07 2010-12-22 Illumina, Inc. Nucleic acid detection methods using universal priming
US6913884B2 (en) 2001-08-16 2005-07-05 Illumina, Inc. Compositions and methods for repetitive use of genomic DNA
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
EP1255865B1 (en) 2000-02-07 2007-04-18 Illumina, Inc. Nucleic acid detection method using universal priming
US6770441B2 (en) 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
US6685813B2 (en) * 2000-02-11 2004-02-03 Aclara Biosciences, Inc. Tandem isotachophoresis/zone electrophoresis method and system
EP1257668B1 (en) 2000-02-16 2008-10-29 Illumina, Inc. Parallel genotyping of multiple patient samples
DE10017790A1 (en) * 2000-04-10 2001-10-11 Basf Ag Process for the production of biopolymer fields with real-time control
US6533903B2 (en) * 2000-04-28 2003-03-18 Princeton University Electrohydrodynamically patterned colloidal crystals
US6921637B2 (en) 2000-05-04 2005-07-26 The Cbr Institute For Biomedical Research, Inc. Colloid compositions for solid phase biomolecular analytical, preparative and identification systems
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
ES2259666T3 (en) 2000-06-21 2006-10-16 Bioarray Solutions Ltd MOLECULAR ANALYSIS OF MULTIPLE ANALYTICS USING SERIES OF RANDOM PARTICLES WITH APPLICATION SPECIFICITY.
DE10051396A1 (en) * 2000-10-17 2002-04-18 Febit Ferrarius Biotech Gmbh An integrated synthesis and identification of an analyte, comprises particles immobilized at a carrier to be coupled to receptors in a structured pattern to give receptor arrays for biochemical reactions
US20030045005A1 (en) * 2000-10-17 2003-03-06 Michael Seul Light-controlled electrokinetic assembly of particles near surfaces
JP2004537712A (en) 2000-10-18 2004-12-16 バーチャル・アレイズ・インコーポレーテッド Multiple cell analysis system
DE10059152C2 (en) * 2000-11-29 2003-03-27 Evotec Ag Microsystem for the dielectric and optical manipulation of particles
US7811768B2 (en) 2001-01-26 2010-10-12 Aviva Biosciences Corporation Microdevice containing photorecognizable coding patterns and methods of using and producing the same
US7015047B2 (en) 2001-01-26 2006-03-21 Aviva Biosciences Corporation Microdevices having a preferential axis of magnetization and uses thereof
US6913697B2 (en) 2001-02-14 2005-07-05 Science & Technology Corporation @ Unm Nanostructured separation and analysis devices for biological membranes
AU2002251956A1 (en) * 2001-02-15 2002-08-28 Caliper Technologies Corp. Methods and systems for enhanced delivery of electrical currents to fluidic systems
US6706163B2 (en) * 2001-03-21 2004-03-16 Michael Seul On-chip analysis of particles and fractionation of particle mixtures using light-controlled electrokinetic assembly of particles near surfaces
US20040146849A1 (en) * 2002-01-24 2004-07-29 Mingxian Huang Biochips including ion transport detecting structures and methods of use
US20050196746A1 (en) * 2001-03-24 2005-09-08 Jia Xu High-density ion transport measurement biochip devices and methods
US20050009004A1 (en) * 2002-05-04 2005-01-13 Jia Xu Apparatus including ion transport detecting structures and methods of use
US20050058990A1 (en) * 2001-03-24 2005-03-17 Antonio Guia Biochip devices for ion transport measurement, methods of manufacture, and methods of use
CA2441366A1 (en) * 2001-03-24 2002-10-03 Aviva Biosciences Corporation Biochips including ion transport detecting structures and methods of use
US20060029955A1 (en) * 2001-03-24 2006-02-09 Antonio Guia High-density ion transport measurement biochip devices and methods
EP1565747B1 (en) * 2001-03-29 2013-11-27 Cellect Technologies Corp. Method and system for separating and sorting particles
EP1390732A4 (en) * 2001-04-03 2006-09-27 Combimatrix Corp Overlying electrode for electrochemical microarrays
US20040121350A1 (en) * 2002-12-24 2004-06-24 Biosite Incorporated System and method for identifying a panel of indicators
US20040203083A1 (en) * 2001-04-13 2004-10-14 Biosite, Inc. Use of thrombus precursor protein and monocyte chemoattractant protein as diagnostic and prognostic indicators in vascular diseases
US7713705B2 (en) * 2002-12-24 2010-05-11 Biosite, Inc. Markers for differential diagnosis and methods of use thereof
US20040253637A1 (en) * 2001-04-13 2004-12-16 Biosite Incorporated Markers for differential diagnosis and methods of use thereof
US20040126767A1 (en) * 2002-12-27 2004-07-01 Biosite Incorporated Method and system for disease detection using marker combinations
ITTO20010411A1 (en) * 2001-05-02 2002-11-02 Silicon Biosystems S R L METHOD AND DEVICE FOR THE EXECUTION OF TESTS AND TESTS WITH HIGH PROCESSIVITY AND HIGH BIOLOGICAL VALUE ON CELLS AND / OR COMPOUNDS.
US6802489B2 (en) * 2001-05-03 2004-10-12 Colorado School Of Mines Micro-fluidic valve with a colloidal particle element
US7262063B2 (en) * 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
US7541003B2 (en) * 2001-07-17 2009-06-02 Bio-Rad Laboratories, Inc. Latex based adsorbent chip
US20030119028A1 (en) * 2001-08-08 2003-06-26 Graves David J. Device and methods for enhanced microarray hybridization reactions
US20030044801A1 (en) * 2001-09-05 2003-03-06 Harvey Thomas B. Array using microspheres
EP2722395B1 (en) 2001-10-15 2018-12-19 Bioarray Solutions Ltd Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection
US20030219800A1 (en) * 2001-10-18 2003-11-27 Beske Oren E. Multiplexed cell transfection using coded carriers
US6545816B1 (en) * 2001-10-19 2003-04-08 Lucent Technologies Inc. Photo-tunable liquid microlens
US20040005258A1 (en) * 2001-12-12 2004-01-08 Fonash Stephen J. Chemical reactor templates: sacrificial layer fabrication and template use
DE10164358C2 (en) * 2001-12-28 2003-11-27 Advalytix Ag Characterization process for functionalized surfaces
US7335153B2 (en) * 2001-12-28 2008-02-26 Bio Array Solutions Ltd. Arrays of microparticles and methods of preparation thereof
AU2003205104A1 (en) 2002-01-11 2003-07-30 The Pennsylvania State University Method of forming a removable support with a sacrificial layers and of transferring devices
WO2003066191A1 (en) * 2002-02-04 2003-08-14 Colorado School Of Mines Laminar flow-based separations of colloidal and cellular particles
DK1502102T3 (en) * 2002-03-11 2009-05-04 Caprotec Bioanalytics Gmbh Compounds and Methods for Analyzing the Proteome
EP1501924A4 (en) * 2002-05-04 2006-05-24 Aviva Biosciences Corp Apparatus including ion transport detecting structures and methods of use
US20040126773A1 (en) * 2002-05-23 2004-07-01 Beske Oren E. Assays with coded sensor particles to sense assay conditions
US6958132B2 (en) * 2002-05-31 2005-10-25 The Regents Of The University Of California Systems and methods for optical actuation of microfluidics based on opto-electrowetting
US7595883B1 (en) 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
ES2375724T3 (en) 2002-09-27 2012-03-05 The General Hospital Corporation MICROFLUDE DEVICE FOR SEPERATION OF CELLS AND ITS USES.
AU2003284179A1 (en) * 2002-10-25 2004-05-13 Inventqjaya Sdn Bhd Fluid deionization system
WO2004047007A1 (en) 2002-11-15 2004-06-03 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
WO2004064972A2 (en) 2003-01-16 2004-08-05 Hk Pharmaceuticals, Inc. Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
US20040161862A1 (en) * 2003-02-15 2004-08-19 Golovlev Valeri V. Method of visualization and quantification of biopolymer molecules immobilized on solid support
EP1618206A4 (en) * 2003-04-30 2006-11-29 Biovitesse Apparatus and method for detecting live cells with an integrated filter and growth detection device
US7437556B2 (en) * 2003-05-09 2008-10-14 Sun Microsystems, Inc. Global visibility controls for operating system partitions
US20040229269A1 (en) * 2003-05-15 2004-11-18 Ghazala Hashmi Hybridization-mediated analysis of polymorphisms
US7530795B2 (en) * 2003-06-13 2009-05-12 Canon Kabushiki Kaisha Fluid control mechanism
TW200508609A (en) * 2003-07-15 2005-03-01 Bioarray Solutions Ltd Detection of cell membrane-associated proteins using membrane fragments displayed on encoded microparticle arrays
JP2005077284A (en) * 2003-09-01 2005-03-24 Seiko Epson Corp Manufacturing device and method for particle array, and method of detecting target substance
US7488451B2 (en) * 2003-09-15 2009-02-10 Millipore Corporation Systems for particle manipulation
EP1676133A4 (en) * 2003-09-15 2008-05-21 Millipore Corp Assays with primary cells
WO2005029705A2 (en) 2003-09-18 2005-03-31 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
ES2375962T3 (en) 2003-09-22 2012-03-07 Bioarray Solutions Ltd IMMOBILIZED SURFACE POLYELECTROLYTE WITH MULTIPLE FUNCTIONAL GROUPS ABLE TO JOIN COVALENTLY TO BIOMOLECULES.
EP1692298A4 (en) 2003-10-28 2008-08-13 Bioarray Solutions Ltd Optimization of gene expression analysis using immobilized capture probes
US20050089916A1 (en) * 2003-10-28 2005-04-28 Xiongwu Xia Allele assignment and probe selection in multiplexed assays of polymorphic targets
ES2533876T3 (en) 2003-10-29 2015-04-15 Bioarray Solutions Ltd Multiplexed nucleic acid analysis by double stranded DNA fragmentation
US7776531B1 (en) 2004-03-25 2010-08-17 Illumina, Inc. Compositions and methods for stabilizing surface bound probes
US7363170B2 (en) * 2004-07-09 2008-04-22 Bio Array Solutions Ltd. Transfusion registry network providing real-time interaction between users and providers of genetically characterized blood products
US20060019406A1 (en) * 2004-07-23 2006-01-26 Ning Wei Lateral flow device for the detection of large pathogens
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
ATE469924T1 (en) * 2004-08-03 2010-06-15 Agency Science Tech & Res POLYMER WITH INTERCONNECTED PORES FOR DRUG DELIVERY AND METHOD
US7977050B2 (en) * 2004-09-02 2011-07-12 Bioarray Solutions, Ltd. Nucleic acid amplification with integrated multiplex detection
US7828954B2 (en) * 2004-09-21 2010-11-09 Gamida For Life B.V. Electrode based patterning of thin film self-assembled nanoparticles
US20060068500A1 (en) * 2004-09-28 2006-03-30 Kimberly-Clark Worldwide, Inc. Detecting yeast infections using a lateral flow assay
US20070240757A1 (en) * 2004-10-15 2007-10-18 The Trustees Of Boston College Solar cells using arrays of optical rectennas
US20060091015A1 (en) * 2004-11-01 2006-05-04 Applera Corporation Surface modification for non-specific adsorption of biological material
US20060171846A1 (en) * 2005-01-10 2006-08-03 Marr David W M Microfluidic systems incorporating integrated optical waveguides
US7088116B1 (en) 2005-02-09 2006-08-08 Haian Lin Optoelectronic probe
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
HU0500406D0 (en) * 2005-04-22 2005-06-28 Mta Szegedi Biolog Koezpont Microfluidic device and method for manipulating electroosmotically moved fluid
US8486629B2 (en) * 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US7649665B2 (en) * 2005-08-24 2010-01-19 The Trustees Of Boston College Apparatus and methods for optical switching using nanoscale optics
US7634162B2 (en) * 2005-08-24 2009-12-15 The Trustees Of Boston College Apparatus and methods for nanolithography using nanoscale optics
US7589880B2 (en) * 2005-08-24 2009-09-15 The Trustees Of Boston College Apparatus and methods for manipulating light using nanoscale cometal structures
KR20080069958A (en) 2005-08-24 2008-07-29 더 트러스티스 오브 보스턴 칼리지 Apparatus and methods for solar energy conversion using nanoscale cometal structures
US7754964B2 (en) * 2005-08-24 2010-07-13 The Trustees Of Boston College Apparatus and methods for solar energy conversion using nanocoax structures
DE102005041061A1 (en) * 2005-08-30 2007-03-08 Kühner, Ferdinand Method for controlled movement of absorbed polymers on a surface, involves preparing surfaces on which soluble polymer can be absorbed
US20070059716A1 (en) * 2005-09-15 2007-03-15 Ulysses Balis Methods for detecting fetal abnormality
US7501483B2 (en) * 2005-09-19 2009-03-10 The University Of Chicago Molecule nanoweaver
US20070095667A1 (en) * 2005-10-27 2007-05-03 Applera Corporation Optoelectronic Separation of Biomolecules
US20070095666A1 (en) * 2005-10-27 2007-05-03 Applera Corporation Surface Modification in a Manipulation Chamber
US9487812B2 (en) 2012-02-17 2016-11-08 Colorado School Of Mines Optical alignment deformation spectroscopy
US9878326B2 (en) * 2007-09-26 2018-01-30 Colorado School Of Mines Fiber-focused diode-bar optical trapping for microfluidic manipulation
US8119976B2 (en) * 2007-07-03 2012-02-21 Colorado School Of Mines Optical-based cell deformability
US9885644B2 (en) 2006-01-10 2018-02-06 Colorado School Of Mines Dynamic viscoelasticity as a rapid single-cell biomarker
US20070243534A1 (en) * 2006-04-12 2007-10-18 Michael Seul Probe density considerations and elongation of self-complementary looped probes where probes are attached to a solid phase
US20080007838A1 (en) * 2006-07-07 2008-01-10 Omnitech Partners, Inc. Field-of-view indicator, and optical system and associated method employing the same
US20100055459A1 (en) * 2006-08-30 2010-03-04 Liquidia Technologies, Inc. Nanoparticles Having Functional Additives for Self and Directed Assembly and Methods of Fabricating Same
JP4825697B2 (en) * 2007-01-25 2011-11-30 株式会社ミツトヨ Digital displacement measuring instrument
EP2115782A1 (en) * 2007-01-30 2009-11-11 Solasta, Inc. Photovoltaic cell and method of making thereof
JP2010518623A (en) * 2007-02-12 2010-05-27 ソーラスタ インコーポレイテッド Photocell with reduced hot carrier cooling
EP2168170A2 (en) * 2007-07-03 2010-03-31 Solasta, Inc. Distributed coax photovoltaic device
US20090062828A1 (en) * 2007-09-04 2009-03-05 Colorado School Of Mines Magnetic field-based colloidal atherectomy
US10722250B2 (en) 2007-09-04 2020-07-28 Colorado School Of Mines Magnetic-field driven colloidal microbots, methods for forming and using the same
US20090286286A1 (en) * 2007-11-06 2009-11-19 Ambergen , Inc. Methods for controlling amplification
JP4561869B2 (en) * 2008-05-08 2010-10-13 ソニー株式会社 Microbead automatic identification method and microbead
WO2010003132A1 (en) 2008-07-02 2010-01-07 Illumina Cambridge Ltd. Using populations of beads for the fabrication of arrays on surfaces
WO2010085548A2 (en) * 2009-01-22 2010-07-29 Li-Cor, Inc. Single molecule proteomics with dynamic probes
US8894260B2 (en) * 2009-03-31 2014-11-25 Sicpa Holding Sa Annular light guide illuminator and optical scanner
CN102449163A (en) 2009-04-03 2012-05-09 加利福尼亚大学董事会 Methods and devices for sorting cells and other biological particulates
GB0913258D0 (en) 2009-07-29 2009-09-02 Dynex Technologies Inc Reagent dispenser
US9523701B2 (en) 2009-07-29 2016-12-20 Dynex Technologies, Inc. Sample plate systems and methods
US8323465B2 (en) * 2009-09-30 2012-12-04 Honeywell International Inc. Three-dimensionally ordered macroporous sensor apparatus and method
US9523680B2 (en) 2010-06-30 2016-12-20 Ambergen, Inc. Global Proteomic screening of random bead arrays using mass spectrometry imaging
US8753873B2 (en) 2011-04-15 2014-06-17 Roche Nimblegen, Inc. Multiplexed microarray assembly and method for fabricating a multiplexed microarray
US9135497B2 (en) 2012-01-27 2015-09-15 National Instruments Corporation Identifying randomly distributed microparticles in images to sequence a polynucleotide
US9731293B2 (en) * 2012-10-03 2017-08-15 The United States Of America, As Represented By The Secretary Of The Navy Paired laser and electrokinetic separation, manipulation, and analysis device
US9857333B2 (en) 2012-10-31 2018-01-02 Berkeley Lights, Inc. Pens for biological micro-objects
US9403172B2 (en) 2012-11-08 2016-08-02 Berkeley Lights, Inc. Circuit based optoelectronic tweezers
US9548411B2 (en) * 2013-03-15 2017-01-17 Sandia Corporation Photoelectrochemically driven self-assembly method
SG10202002543UA (en) 2013-10-22 2020-05-28 Berkeley Lights Inc Micro-fluidic devices for assaying biological activity
KR102358356B1 (en) 2013-10-22 2022-02-08 버클리 라잇츠, 인크. Microfluidic devices having isolation pens and methods of testing biological micro-objects with same
US9889445B2 (en) 2013-10-22 2018-02-13 Berkeley Lights, Inc. Micro-fluidic devices for assaying biological activity
US9849464B2 (en) 2014-04-18 2017-12-26 The Regents Of The University Of Michigan Devices and methods for spatially and temporally reconfigurable assembly of colloidal crystals
US11192107B2 (en) 2014-04-25 2021-12-07 Berkeley Lights, Inc. DEP force control and electrowetting control in different sections of the same microfluidic apparatus
US20150306599A1 (en) 2014-04-25 2015-10-29 Berkeley Lights, Inc. Providing DEP Manipulation Devices And Controllable Electrowetting Devices In The Same Microfluidic Apparatus
US10006882B2 (en) 2014-11-21 2018-06-26 EnLiSense, LLC Biosensing system and methods using electron-ionic mechanisms at fluid-sensor interfaces
US9815056B2 (en) 2014-12-05 2017-11-14 The Regents Of The University Of California Single sided light-actuated microfluidic device with integrated mesh ground
CN107249742B (en) 2014-12-08 2019-12-06 伯克利之光生命科技公司 Directional flow actuated microfluidic structures in microfluidic devices and methods of using the same
TWI721545B (en) 2014-12-08 2021-03-11 美商柏克萊燈光有限公司 Lateral/vertical transistor structures and processes of making and using same
CN113075113A (en) 2014-12-09 2021-07-06 伯克利之光生命科技公司 Automated detection and repositioning of micro-objects in microfluidic devices
US10578630B2 (en) 2014-12-09 2020-03-03 Berkeley Lights, Inc. Automated identification of assay areas in a microfluidic device and detection of assay positive areas based on rate of change of image light intensity
WO2016094507A2 (en) 2014-12-10 2016-06-16 Berkeley Lights, Inc. Systems for operating electrokinetic devices
US9744533B2 (en) 2014-12-10 2017-08-29 Berkeley Lights, Inc. Movement and selection of micro-objects in a microfluidic apparatus
CA2976946C (en) * 2015-02-24 2023-09-19 City Of Hope Chemically encoded spatially addressed library screening platforms
US10101250B2 (en) 2015-04-22 2018-10-16 Berkeley Lights, Inc. Manipulation of cell nuclei in a micro-fluidic device
KR102334118B1 (en) 2015-04-22 2021-12-01 버클리 라잇츠, 인크. Freezing and archiving cells on a microfluidic device
US10751715B1 (en) 2015-04-22 2020-08-25 Berkeley Lights, Inc. Microfluidic reporter cell assay methods and kits thereof
SG11201708429WA (en) 2015-04-22 2017-11-29 Berkeley Lights Inc Microfluidic cell culture
KR20180020964A (en) 2015-04-27 2018-02-28 더 리젠츠 오브 더 유니버시티 오브 미시건 Durable eye sporty surface
US20170049214A1 (en) * 2015-08-17 2017-02-23 Emmett Pierre Pope Multipurpose mascara and eyeliner applicator device
US10799865B2 (en) 2015-10-27 2020-10-13 Berkeley Lights, Inc. Microfluidic apparatus having an optimized electrowetting surface and related systems and methods
IL299366A (en) 2015-11-23 2023-02-01 Berkeley Lights Inc In situ-generated microfluidic isolation structures, kits and methods of use thereof
EP4102226A1 (en) 2015-12-08 2022-12-14 Berkeley Lights, Inc. In situ-generated microfluidic assay structures, related kits, and methods of use thereof
JP6964590B2 (en) 2015-12-30 2021-11-10 バークレー ライツ,インコーポレイテッド Optically driven convection and displacement microfluidic devices, their kits and methods
TWI808934B (en) 2015-12-31 2023-07-21 美商伯克利之光生命科技公司 Tumor infilitrating cells engineered to express a pro-inflammatory polypeptide
EP3402814B1 (en) 2016-01-15 2021-04-21 Berkeley Lights, Inc. Methods of producing patient-specific anti-cancer therapeutics and methods of treatment therefor
WO2017160991A1 (en) 2016-03-16 2017-09-21 Lavieu Gregory G Methods, systems and devices for selection and generation of genome edited clones
WO2017181135A2 (en) 2016-04-15 2017-10-19 Berkeley Lights, Inc. Methods, systems and kits for in-pen assays
US10675625B2 (en) 2016-04-15 2020-06-09 Berkeley Lights, Inc Light sequencing and patterns for dielectrophoretic transport
DE112017008349B3 (en) * 2016-05-26 2023-06-07 Nec Corporation Communication system, control device, communication terminal, communication device and communication method
CA3022623A1 (en) 2016-05-26 2017-11-30 Berkeley Lights, Inc. Covalently modified surfaces, kits, and methods of preparation and use
SG11201900442PA (en) 2016-07-21 2019-02-27 Berkeley Lights Inc Sorting of t lymphocytes in a microfluidic device
AU2017388874A1 (en) 2016-12-30 2019-07-18 Berkeley Lights, Inc. Methods for selection and generation of genome edited T cells
US10279068B2 (en) 2017-03-01 2019-05-07 Dbg Group Investments, Llc Method and device for enhancing the reduction of pathogens, allergens and odor-causing agents
US11251889B2 (en) 2017-03-16 2022-02-15 Battelle Energy Alliance, Llc Wireless signal monitoring and analysis, and related methods, systems, and devices
EP3721209B1 (en) 2017-10-15 2024-02-07 Berkeley Lights, Inc. Methods for in-pen assays
CN109810894B (en) * 2019-03-01 2022-06-10 长春理工大学 Group cell three-dimensional structure manipulation and construction system and method based on light-induced dielectrophoresis
WO2020223555A1 (en) 2019-04-30 2020-11-05 Berkeley Lights, Inc. Methods for encapsulating and assaying cells

Family Cites Families (589)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US620737A (en) * 1899-03-07 chapman
US6123A (en) * 1849-02-20 Improvement in horse-rakes
US4575407A (en) * 1962-12-03 1986-03-11 Diller Isaac M Product and process for the activation of an electrolytic cell
US3329638A (en) 1963-09-05 1967-07-04 Monsanto Co Multilayered polymeric latices with hydrophilic surface layer
US3574614A (en) * 1967-01-06 1971-04-13 Xerox Corp Process of preparing multiple copies from a xeroprinting master
US3571614A (en) 1968-08-05 1971-03-23 Hughes Aircraft Co Transistor switch with minimized transition power absorption
US3989775A (en) * 1971-03-01 1976-11-02 Bakelite Xylonite Limited Method of making a retro-reflective beaded material
US3790492A (en) 1971-03-11 1974-02-05 Atomic Energy Commission Method for production of uniform microspheres
US3982182A (en) 1973-08-13 1976-09-21 Coulter Electronics, Inc. Conductivity cell for particle study device
US3998525A (en) * 1973-10-26 1976-12-21 American Cyanamid Company Edge lighted electrochromic displays
US3957741A (en) 1974-01-17 1976-05-18 California Institute Of Technology Crosslinked, porous, polyacrylate beads
BE833512A (en) 1974-09-17 1976-03-17 NEW COMPOSITION OF LATEX LOADED WITH A HYDROPHOBIC COMPOUND, ITS PREPARATION AND ITS PHOTOGRAPHIC APPLICATION
DE2502621C3 (en) 1975-01-23 1978-09-14 Kernforschungsanlage Juelich Gmbh, 5170 Juelich Measurement of elastic and dielectric properties of the membrane of living cells
GB1568111A (en) * 1975-07-22 1980-05-29 Phosphor Prod Co Ltd Electroluminescent devices
US4003713A (en) 1975-08-14 1977-01-18 Bowser Everett N Multiple test tube evaporator
US4275053A (en) 1975-08-14 1981-06-23 Mt. Sinai School Of Medicine Of The City University Of New York Blood cell typing and compatibility test procedure
US4046667A (en) 1975-10-30 1977-09-06 Pen Kem, Inc. Microelectrophoresis apparatus
US4143203A (en) 1976-03-19 1979-03-06 Amicon Corporation Particulate support material
US4326008A (en) 1976-08-27 1982-04-20 California Institute Of Technology Protein specific fluorescent microspheres for labelling a protein
US4075013A (en) * 1976-09-13 1978-02-21 Ward Anthony T Electrophotochemical preparation of selenium photoconductive members
US4102990A (en) 1977-12-05 1978-07-25 General Electric Company Electrophoretic assay for antigen-antibody reaction based on particle-particle coupling
AU530410B2 (en) 1978-02-21 1983-07-14 Sintef Preparing aqueous emulsions
US4258001A (en) 1978-12-27 1981-03-24 Eastman Kodak Company Element, structure and method for the analysis or transport of liquids
US4267235A (en) 1979-03-19 1981-05-12 California Institute Of Technology Polyglutaraldehyde microspheres
IT1145696B (en) 1979-08-24 1986-11-05 Rhone Poulenc Ind PREPARATION PROCEDURE FOR MAGNETIC PEARLS OF VINYLAROMATIC POLYMERS
GB2058379A (en) * 1979-09-12 1981-04-08 Agfa Gevaert Imaging Process
US4421896A (en) 1979-11-13 1983-12-20 The Dow Chemical Company Method of coupling a protein to a polymer particle containing hydrazide groups in a polymer latex and the products formed therefrom
US4806776A (en) * 1980-03-10 1989-02-21 Kley Victor B Electrical illumination and detecting apparatus
FR2480764B1 (en) 1980-04-18 1985-10-04 Rhone Poulenc Spec Chim LATEX OF MAGNETIC POLYMERS AND PREPARATION METHOD
US4383529A (en) 1980-11-03 1983-05-17 Wescor, Inc. Iontophoretic electrode device, method and gel insert
DE3116995A1 (en) 1981-04-29 1982-11-25 Röhm GmbH, 6100 Darmstadt LATEX FOR IMMOBILIZING BIOLOGICALLY EFFECTIVE SUBSTANCES
JPS5844340A (en) * 1981-09-10 1983-03-15 Kureha Chem Ind Co Ltd Method and apparatus for measuring electrophoretic mobility
US4542250A (en) * 1982-01-09 1985-09-17 The British Petroleum Company, P.L.C. Use of stabilized pillared interlayered clays as catalyst in alkylation reactions
NO155316C (en) 1982-04-23 1987-03-11 Sintef PROCEDURE FOR MAKING MAGNETIC POLYMER PARTICLES.
US4499052A (en) 1982-08-30 1985-02-12 Becton, Dickinson And Company Apparatus for distinguishing multiple subpopulations of cells
US4717655A (en) 1982-08-30 1988-01-05 Becton, Dickinson And Company Method and apparatus for distinguishing multiple subpopulations of cells
US4994373A (en) 1983-01-27 1991-02-19 Enzo Biochem, Inc. Method and structures employing chemically-labelled polynucleotide probes
US4487855A (en) 1983-02-15 1984-12-11 Shih Yen Jer Colored latexes; methods for making same and colored finely divided products
US4824941A (en) 1983-03-10 1989-04-25 Julian Gordon Specific antibody to the native form of 2'5'-oligonucleotides, the method of preparation and the use as reagents in immunoassays or for binding 2'5'-oligonucleotides in biological systems
US4672040A (en) * 1983-05-12 1987-06-09 Advanced Magnetics, Inc. Magnetic particles for use in separations
DE3322373C2 (en) * 1983-05-19 1986-12-04 Ioannis Dr. 3000 Hannover Tripatzis Test means and methods for the detection of antigens and / or antibodies
US4497208A (en) 1983-06-23 1985-02-05 Matec, Inc. Measurement of electro-kinetic properties of a solution
USRE34405E (en) 1983-08-01 1993-10-12 Abbott Laboratories Determination of analytes in particle-containing medium
US4591550A (en) * 1984-03-01 1986-05-27 Molecular Devices Corporation Device having photoresponsive electrode for determining analytes including ligands and antibodies
US4665020A (en) * 1984-05-30 1987-05-12 United States Department Of Energy Flow cytometer measurement of binding assays
US4647544A (en) 1984-06-25 1987-03-03 Nicoli David F Immunoassay using optical interference detection
US5026545A (en) * 1984-09-17 1991-06-25 Baxter International, Inc. Treatment of allergy and composition therefor
SE454885B (en) 1984-10-19 1988-06-06 Exploaterings Ab Tbf POLYMER COATED PARTICLES WITH IMMOBILIZED METAL ZONES IN ITS SURFACE PROCEDURES FOR PRODUCING THEREOF
US4774189A (en) 1984-12-24 1988-09-27 Flow Cytometry Standards Corp. Fluorescent calibration microbeads simulating stained cells
US5073498A (en) 1984-12-24 1991-12-17 Caribbean Microparticles Corporation Fluorescent alignment microbeads with broad excitation and emission spectra and its use
US4702598A (en) 1985-02-25 1987-10-27 Research Corporation Flow cytometer
US4613559A (en) 1985-04-01 1986-09-23 Xerox Corporation Process for colored toner compositions with controlled charges thereon
US5354825A (en) 1985-04-08 1994-10-11 Klainer Stanley M Surface-bound fluorescent polymers and related methods of synthesis and use
US4806313A (en) 1985-04-12 1989-02-21 E. I. Du Pont De Nemours And Company Rapid assay processor
US4753775A (en) 1985-04-12 1988-06-28 E. I. Du Pont De Nemours And Company Rapid assay processor
US4602989A (en) 1985-09-17 1986-07-29 Dorr-Oliver Incorporated Method and apparatus for determining the zeta potential of colloidal particles
US4679439A (en) 1985-09-17 1987-07-14 Dorr-Oliver Incorporated Method and apparatus for measuring the unsteady sedimentation potential of colloidal particles
US4795698A (en) 1985-10-04 1989-01-03 Immunicon Corporation Magnetic-polymer particles
US4663408A (en) 1985-12-30 1987-05-05 Exxon Research And Engineering Company Tetrapolymers of N-vinyl pyrrolidone/acrylamide/salt of acrylic acid/N-alkyl acrylamide
US4680332A (en) 1986-01-24 1987-07-14 Xerox Corporation Ink jet compositions and process for preparation thereof
US5604099A (en) 1986-03-13 1997-02-18 Hoffmann-La Roche Inc. Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
JPS62265567A (en) 1986-05-12 1987-11-18 Seitetsu Kagaku Co Ltd Method for discriminating blood group
US4851331A (en) 1986-05-16 1989-07-25 Allied Corporation Method and kit for polynucleotide assay including primer-dependant DNA polymerase
GB8612087D0 (en) 1986-05-19 1986-06-25 Ici Plc Hybridisation probes
US5252494A (en) 1986-06-25 1993-10-12 Trustees Of Tufts College Fiber optic sensors, apparatus, and detection methods using controlled release polymers and reagent formulations held within a polymeric reaction matrix
US5143853A (en) 1986-06-25 1992-09-01 Trustees Of Tufts College Absorbance modulated fluorescence detection methods and sensors
US4822746A (en) 1986-06-25 1989-04-18 Trustees Of Tufts College Radiative and non-radiative energy transfer and absorbance modulated fluorescence detection methods and sensors
US5114864A (en) 1986-06-25 1992-05-19 Trustees Of Tufts College Fiber optic sensors, apparatus, and detection methods using fluid erodible controlled release polymers for delivery of reagent formulations
US5254477A (en) 1986-06-25 1993-10-19 Trustees Of Tufts College Flourescence intramolecular energy transfer conjugate compositions and detection methods
CA1340806C (en) 1986-07-02 1999-11-02 James Merrill Prober Method, system and reagents for dna sequencing
US4791310A (en) 1986-10-02 1988-12-13 Syracuse University Fluorescence microscopy
US5015452A (en) 1986-11-17 1991-05-14 Clarkson University Process for synthesis of uniform colloidal particles of rare earth oxides
DE3681176D1 (en) 1986-12-01 1991-10-02 Molecular Biosystems Inc METHOD FOR INCREASING THE SENSITIVITY OF NUCLEIC ACID HYBRIDIZATION TESTS.
US4891324A (en) 1987-01-07 1990-01-02 Syntex (U.S.A.) Inc. Particle with luminescer for assays
US5132097A (en) 1987-02-11 1992-07-21 G.D. Research Apparatus for analysis of specific binding complexes
US4911806A (en) 1987-02-27 1990-03-27 Biotronics Method and apparatus for separating particles in liquid suspension utilizing oscillating electric and magnetic fields
US5155044A (en) 1987-03-13 1992-10-13 Coulter Electronics, Inc. Lysing reagent system for isolation, identification and/or analysis of leukocytes from whole blood samples
EP0289764A3 (en) 1987-04-07 1989-10-18 Liebherr-Hausgeräte Gmbh Foam-filling method for the bell-shaped hollow space between inner and outer walls of containers or the like, preferably the hollow space between the inner and outer walls of refrigerators or freezers
US5241012A (en) 1987-05-19 1993-08-31 Applied Immune Sciences, Inc. Activated and conjugated polystyrene substrate
US5389549A (en) 1987-05-29 1995-02-14 Toa Medical Electronics Co., Ltd. Method for classifying leukocytes and a reagent used therefor
SE458968B (en) 1987-06-16 1989-05-22 Wallac Oy BIOSPECIFIC ANALYTICAL PROCEDURE FOR MULTIPLE ANALYTICS WHICH DO NOT INCLUDE PARTICULAR COATING AND LABELING WITH FLUORESCING LABEL SUBSTANCES
US5194300A (en) 1987-07-15 1993-03-16 Cheung Sau W Methods of making fluorescent microspheres
US5132242A (en) 1987-07-15 1992-07-21 Cheung Sau W Fluorescent microspheres and methods of using them
US5807755A (en) 1987-08-06 1998-09-15 Multilyte Limited Determination of ambient concentrations of several analytes
US5395688A (en) 1987-10-26 1995-03-07 Baxter Diagnostics Inc. Magnetically responsive fluorescent polymer particles
US6013531A (en) 1987-10-26 2000-01-11 Dade International Inc. Method to use fluorescent magnetic polymer particles as markers in an immunoassay
US5091206A (en) 1987-10-26 1992-02-25 Baxter Diagnostics Inc. Process for producing magnetically responsive polymer particles and application thereof
US4832814A (en) 1987-12-28 1989-05-23 E. I. Du Pont De Nemours And Company Electrofusion cell and method of making the same
JPH0694483B2 (en) 1988-01-29 1994-11-24 三田工業株式会社 Method for producing monodisperse polymer particles with increased particle size
US4920056A (en) 1988-02-19 1990-04-24 The Dow Chemical Company Apparatus and method for automated microbatch reaction
US4873102A (en) 1988-03-14 1989-10-10 Manchium Chang Magnetic particles
US4847544A (en) * 1988-03-28 1989-07-11 Nec Electronics Inc. Microcomputer control of stepper motor using reduced number of parts
US5244630A (en) 1988-04-22 1993-09-14 Abbott Laboratories Device for performing solid-phase diagnostic assay
US5002867A (en) 1988-04-25 1991-03-26 Macevicz Stephen C Nucleic acid sequence determination by multiple mixed oligonucleotide probes
US6054270A (en) 1988-05-03 2000-04-25 Oxford Gene Technology Limited Analying polynucleotide sequences
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
NO164622C (en) 1988-05-11 1990-10-24 Tore Lindmo BINAER IMMUNOMETRIC PARTICLE-BASED METHOD FOR MEASURING SPECIFIC SERUM ANTIGENS USING LIQUID FLOW MICROPHOTOMETRY AND A PREPARED TARGET SET UP THEREOF.
US5185066A (en) 1988-08-11 1993-02-09 Helena Laboratories Corporation Immunofixation electrophoresis control system
US5173159A (en) 1988-09-06 1992-12-22 Bertin & Cie Multiple electrophoresis method for the controlled migration of macromolecules through rectangular gel plates
US6150089A (en) 1988-09-15 2000-11-21 New York University Method and characterizing polymer molecules or the like
US6147198A (en) 1988-09-15 2000-11-14 New York University Methods and compositions for the manipulation and characterization of individual nucleic acid molecules
GB8822228D0 (en) 1988-09-21 1988-10-26 Southern E M Support-bound oligonucleotides
US5266427A (en) 1988-10-18 1993-11-30 Nippondenso Co., Ltd. Display board and method for producing the same
US5779976A (en) 1988-11-03 1998-07-14 Igen International, Inc. Apparatus for improved luminescence assays
FR2638848B1 (en) 1988-11-04 1993-01-22 Chemunex Sa METHOD OF DETECTION AND / OR DETERMINATION IN A LIQUID OR SEMI-LIQUID MEDIUM OF AT LEAST ONE ORGANIC, BIOLOGICAL OR MEDICINAL SUBSTANCE, BY AN AGGLUTINATION METHOD
US5512439A (en) 1988-11-21 1996-04-30 Dynal As Oligonucleotide-linked magnetic particles and uses thereof
US5536648A (en) * 1988-12-09 1996-07-16 Amrad Corporation Limited Amplified DNA assay using a double stranded DNA binding protein
US5856092A (en) * 1989-02-13 1999-01-05 Geneco Pty Ltd Detection of a nucleic acid sequence or a change therein
US5234809A (en) 1989-03-23 1993-08-10 Akzo N.V. Process for isolating nucleic acid
FR2645160B1 (en) 1989-03-31 1992-10-02 Rhone Poulenc Chimie
US6610256B2 (en) 1989-04-05 2003-08-26 Wisconsin Alumni Research Foundation Image processing and analysis of individual nucleic acid molecules
JPH02299598A (en) 1989-04-14 1990-12-11 Ro Inst For Molecular Genetics & Geneteic Res Determination by means of hybridization, together with oligonucleotide probe of all or part of extremely short sequence in sample of nucleic acid connecting with separate particle of microscopic size
US5075217A (en) 1989-04-21 1991-12-24 Marshfield Clinic Length polymorphisms in (dC-dA)n ·(dG-dT)n sequences
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6551784B2 (en) 1989-06-07 2003-04-22 Affymetrix Inc Method of comparing nucleic acid sequences
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5698271A (en) 1989-08-22 1997-12-16 Immunivest Corporation Methods for the manufacture of magnetically responsive particles
GB8920571D0 (en) 1989-09-12 1989-10-25 Carr Robert J G Examination of objects of macromolecular size
US5545522A (en) 1989-09-22 1996-08-13 Van Gelder; Russell N. Process for amplifying a target polynucleotide sequence using a single primer-promoter complex
US5736349A (en) 1989-09-29 1998-04-07 Nippon Paint Co., Ltd. Magnetic particle and immunoassay using the same
ATE106566T1 (en) * 1989-11-21 1994-06-15 Bayer Ag OPTICAL BIOSENSOR.
EP0463144B1 (en) 1989-12-14 1997-02-05 Dade International Inc. Magnetically responsive fluorescent polymer particles and application thereof
US5523231A (en) 1990-02-13 1996-06-04 Amersham International Plc Method to isolate macromolecules using magnetically attractable beads which do not specifically bind the macromolecules
JPH03236777A (en) 1990-02-14 1991-10-22 Toto Ltd Immobilization of enzyme
US6013431A (en) 1990-02-16 2000-01-11 Molecular Tool, Inc. Method for determining specific nucleotide variations by primer extension in the presence of mixture of labeled nucleotides and terminators
US5189549A (en) * 1990-02-26 1993-02-23 Molecular Displays, Inc. Electrochromic, electroluminescent and electrochemiluminescent displays
JP2813022B2 (en) * 1990-03-12 1998-10-22 三菱電機株式会社 Vehicle control device
US5126239A (en) 1990-03-14 1992-06-30 E. I. Du Pont De Nemours And Company Process for detecting polymorphisms on the basis of nucleotide differences
JPH03276493A (en) * 1990-03-26 1991-12-06 Agency Of Ind Science & Technol Josephson memory circuit
US5723218A (en) 1990-04-16 1998-03-03 Molecular Probes, Inc. Dipyrrometheneboron difluoride labeled flourescent microparticles
US5326692B1 (en) 1992-05-13 1996-04-30 Molecular Probes Inc Fluorescent microparticles with controllable enhanced stokes shift
EP0745689A3 (en) * 1990-05-11 1996-12-11 Microprobe Corporation A dipstick for a nucleic acid hybridization assay
WO1991019023A2 (en) * 1990-05-25 1991-12-12 Savin Corporation Electrophoretically deposited particle coatings and structures made therefrom
US5147777A (en) * 1990-06-18 1992-09-15 Eastman Kodak Company Biologically active reagents prepared from carboxy-containing polymer, analytical element and methods of use
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
US5281370A (en) 1990-08-22 1994-01-25 University Of Pittsburgh Of The Commonwealth System Of Higher Education Method of making solid crystalline narrow band radiation filter
DE4026978A1 (en) 1990-08-25 1992-02-27 Bayer Ag Coated substrates for electro=optical applications, etc.
US5266497A (en) 1990-08-31 1993-11-30 Japan Synthetic Rubber Co., Ltd. Immunochromatographic assay with improved colored latex
EP0478319B1 (en) 1990-09-28 1997-04-02 Kabushiki Kaisha Toshiba Gene detection method
US5002667A (en) * 1990-10-30 1991-03-26 National Research Council Of Canada Fluid fractionating, stacked permeable membrane envelope assembly, and a fluid distributing and permeable membrane sealing collar
US6149789A (en) 1990-10-31 2000-11-21 Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Process for manipulating microscopic, dielectric particles and a device therefor
DE4035714A1 (en) 1990-11-09 1992-05-27 Fraunhofer Ges Forschung Dipole moment and/or concn. measurement - by capacitive measurement of dielectric constant in presence of charge carrier
WO1992008808A1 (en) 1990-11-14 1992-05-29 Siska Diagnostics, Inc. Non-isotopic detection of nucleic acids using a polystyrene support-based sandwich hybridization assay and compositions useful therefor
ES2155822T3 (en) 1990-12-06 2001-06-01 Affymetrix Inc COMPOUNDS AND ITS USE IN A BINARY SYNTHESIS STRATEGY.
NL9002764A (en) * 1990-12-14 1992-07-01 Tno ELECTRODE, FITTED WITH A POLYMER COATING WITH A REDOX ENZYM BOND TO IT.
US5266238A (en) 1990-12-24 1993-11-30 American Cyanamid Company Narrow band radiation filter films
US5225900A (en) 1990-12-31 1993-07-06 Xerox Corporation Method of storing information within a reproduction system
US5105305A (en) 1991-01-10 1992-04-14 At&T Bell Laboratories Near-field scanning optical microscope using a fluorescent probe
US5128006A (en) 1991-01-23 1992-07-07 At&T Bell Laboratories Deposition of diamond films on semicondutor substrates
US5250264A (en) 1991-01-25 1993-10-05 Trustees Of Tufts College Method of making imaging fiber optic sensors to concurrently detect multiple analytes of interest in a fluid sample
US5244636A (en) 1991-01-25 1993-09-14 Trustees Of Tufts College Imaging fiber optic array sensors, apparatus, and methods for concurrently detecting multiple analytes of interest in a fluid sample
US5308749A (en) 1991-01-25 1994-05-03 Eastman Kodak Company Method of preparing biologically active reagents from succinimide-containing polymers, analytical element and methods of use
US5320814A (en) 1991-01-25 1994-06-14 Trustees Of Tufts College Fiber optic array sensors, apparatus, and methods for concurrently visualizing and chemically detecting multiple analytes of interest in a fluid sample
US5244813A (en) 1991-01-25 1993-09-14 Trustees Of Tufts College Fiber optic sensor, apparatus, and methods for detecting an organic analyte in a fluid or vapor sample
US5364759B2 (en) 1991-01-31 1999-07-20 Baylor College Medicine Dna typing with short tandem repeat polymorphisms and identification of polymorphic short tandem repeats
US5784162A (en) 1993-08-18 1998-07-21 Applied Spectral Imaging Ltd. Spectral bio-imaging methods for biological research, medical diagnostics and therapy
JPH04271359A (en) 1991-02-27 1992-09-28 Ricoh Co Ltd Developer for dry processing
US6004744A (en) 1991-03-05 1999-12-21 Molecular Tool, Inc. Method for determining nucleotide identity through extension of immobilized primer
RU1794088C (en) 1991-03-18 1993-02-07 Институт Молекулярной Биологии Ан@ Ссср Method of dna nucleotide sequence determination and a device for its realization
US6451968B1 (en) 1991-05-24 2002-09-17 Isis Pharmaceuticals, Inc. Peptide nucleic acids
JPH05226637A (en) * 1991-06-28 1993-09-03 Oki Electric Ind Co Ltd Method for aligning fine object and manufacture of bio element, method for aligning ultra fine particle, fine wiring method, and manufacture of polarizer using the aligning method
AU2348092A (en) 1991-07-16 1993-02-23 Transmed Biotech Incorporated Methods and compositions for simultaneous analysis of multiple analytes
US5187096A (en) 1991-08-08 1993-02-16 Rensselaer Polytechnic Institute Cell substrate electrical impedance sensor with multiple electrode array
US5627040A (en) 1991-08-28 1997-05-06 Becton Dickinson And Company Flow cytometric method for autoclustering cells
US5474796A (en) 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US5639603A (en) * 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
GB9119940D0 (en) 1991-09-18 1991-10-30 Hare Peter F J O Polypeptide inhibitor of viral replication
AU669489B2 (en) 1991-09-18 1996-06-13 Affymax Technologies N.V. Method of synthesizing diverse collections of oligomers
US5993935A (en) 1991-10-11 1999-11-30 3M Innovative Properties Company Covalently reactive particles incorporated in a continous porous matrix
WO1993008472A1 (en) 1991-10-15 1993-04-29 Multilyte Limited Binding assay employing labelled reagent
US6017696A (en) 1993-11-01 2000-01-25 Nanogen, Inc. Methods for electronic stringency control for molecular biological analysis and diagnostics
US5605662A (en) 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US5632957A (en) * 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US5849486A (en) 1993-11-01 1998-12-15 Nanogen, Inc. Methods for hybridization analysis utilizing electrically controlled hybridization
US6048690A (en) 1991-11-07 2000-04-11 Nanogen, Inc. Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis
IL103674A0 (en) 1991-11-19 1993-04-04 Houston Advanced Res Center Method and apparatus for molecule detection
US5846708A (en) * 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5652059A (en) 1991-11-20 1997-07-29 Bar Ilan University Method for attaching microspheres to a substrate
US5326691A (en) 1991-11-21 1994-07-05 John Hozier Micro-libraries and methods of making and manipulating them methods for generating and analyzing micro-libraries
US5412087A (en) 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
US5348853A (en) 1991-12-16 1994-09-20 Biotronics Corporation Method for reducing non-specific priming in DNA amplification
US5248772A (en) 1992-01-29 1993-09-28 Coulter Corporation Formation of colloidal metal dispersions using aminodextrans as reductants and protective agents
US5221417A (en) 1992-02-20 1993-06-22 At&T Bell Laboratories Conductive adhesive film techniques
JPH07112539B2 (en) 1992-04-15 1995-12-06 工業技術院長 Method and apparatus for producing fine particles
US5667667A (en) 1992-04-24 1997-09-16 Isis Innovation Limited Electrochemical treatment of surfaces
US5308586A (en) 1992-05-01 1994-05-03 General Atomics Electrostatic separator using a bead bed
US5498392A (en) 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5587128A (en) 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
HU9201687D0 (en) 1992-05-21 1992-08-28 Arpad Furka Preparation of sets from peptid mixtures with polycomponents and their use for the identification of biologically active peptides
GB9211176D0 (en) 1992-05-27 1992-07-08 Central Blood Lab Authority Assay
CA2115342C (en) 1992-06-17 2003-08-26 Robert B. Wallace A method of detecting and discriminating between nucleic acid sequences
US5981176A (en) * 1992-06-17 1999-11-09 City Of Hope Method of detecting and discriminating between nucleic acid sequences
DE69303022T2 (en) 1992-06-24 1997-01-23 Lyons KEYBOARD STRUCTURE
DE69313611T2 (en) 1992-07-02 1998-01-08 Erkki Soini BIOS-SPECIFIC MULTIPARAMETER ANALYSIS PROCEDURE
US5329461A (en) 1992-07-23 1994-07-12 Acrogen, Inc. Digital analyte detection system
US5674698A (en) 1992-09-14 1997-10-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
JP3420765B2 (en) 1992-09-14 2003-06-30 エス・アール・アイ・インターナシヨナル Upconvertable reporter for biological and other analysis using laser excitation technology
US5415835A (en) 1992-09-16 1995-05-16 University Of New Mexico Method for fine-line interferometric lithography
KR960003373B1 (en) * 1992-09-29 1996-03-09 후지쓰 가부시키가이샤 Programmable logic circuit
US5565324A (en) 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5714340A (en) 1992-12-22 1998-02-03 Johnson & Johnson Clinical Diagnostics, Inc. Immunoassay elements having a receptor zone
US5298741A (en) 1993-01-13 1994-03-29 Trustees Of Tufts College Thin film fiber optic sensor array and apparatus for concurrent viewing and chemical sensing of a sample
WO1994016105A1 (en) * 1993-01-15 1994-07-21 The Public Health Research Institute Of The City Of New York, Inc. Rna assays using rna binary probes and ribozyme ligase
US5637508A (en) 1993-03-26 1997-06-10 Geo-Centers, Inc. Biomolecules bound to polymer or copolymer coated catalytic inorganic particles, immunoassays using the same and kits containing the same
US5643765A (en) 1993-04-06 1997-07-01 University Of Rochester Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
US5639606A (en) 1993-04-06 1997-06-17 The University Of Rochester Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
JP2842758B2 (en) 1993-05-10 1999-01-06 株式会社日立製作所 Automatic analyzer
ATE366741T1 (en) 1993-05-27 2007-08-15 Aventis Pharma Inc TOPOLOGICALLY SEPARATE, SOLID-PHASE CODING LIBRARIES
US5840485A (en) 1993-05-27 1998-11-24 Selectide Corporation Topologically segregated, encoded solid phase libraries
US5528392A (en) 1993-06-07 1996-06-18 Fuji Photo Film Co., Ltd. Image-forming apparatus having liquid crystal and photoconductive members and using the same light beam for reading and writing
CA2123940A1 (en) 1993-06-21 1994-12-22 Philip A. Guadagno Electrophoresis plate
US5837832A (en) 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US5837501A (en) 1993-07-09 1998-11-17 Akzo Nobel N.V. Nucleic acid quantitation by co-amplification of target with multiple internal controls
US5648124A (en) 1993-07-09 1997-07-15 Seradyn, Inc. Process for preparing magnetically responsive microparticles
US6087186A (en) 1993-07-16 2000-07-11 Irori Methods and apparatus for synthesizing labeled combinatorial chemistry libraries
GB9315847D0 (en) 1993-07-30 1993-09-15 Isis Innovation Tag reagent and assay method
RU2041261C1 (en) 1993-08-11 1995-08-09 Институт молекулярной биологии им.В.А.Энгельгардта РАН Method for manufacturing of matrix for detecting of mismatches
US5382512A (en) * 1993-08-23 1995-01-17 Chiron Corporation Assay device with captured particle reagent
US6251687B1 (en) 1993-09-24 2001-06-26 Biosite Diagnostics, Inc. Fluorescence energy transfer and intramolecular energy transfer in particles using novel compounds
DE69433487T2 (en) 1993-09-27 2004-11-25 Arch Development Corp., Chicago METHODS AND COMPOSITIONS FOR EFFICIENT NUCLEIC ACID SEQUENCING
US5447440A (en) 1993-10-28 1995-09-05 I-Stat Corporation Apparatus for assaying viscosity changes in fluid samples and method of conducting same
US6068818A (en) 1993-11-01 2000-05-30 Nanogen, Inc. Multicomponent devices for molecular biological analysis and diagnostics
US5965452A (en) 1996-07-09 1999-10-12 Nanogen, Inc. Multiplexed active biologic array
US6309602B1 (en) 1993-11-01 2001-10-30 Nanogen, Inc. Stacked, reconfigurable system for electrophoretic transport of charged materials
US6254827B1 (en) 1993-11-01 2001-07-03 Nanogen, Inc. Methods for fabricating multi-component devices for molecular biological analysis and diagnostics
US6319472B1 (en) 1993-11-01 2001-11-20 Nanogen, Inc. System including functionally separated regions in electrophoretic system
WO1995012608A1 (en) 1993-11-02 1995-05-11 Affymax Technologies N.V. Synthesizing and screening molecular diversity
US5610287A (en) 1993-12-06 1997-03-11 Molecular Tool, Inc. Method for immobilizing nucleic acid molecules
GB9326450D0 (en) 1993-12-24 1994-02-23 Multilyte Ltd Binding assay
US5496997A (en) 1994-01-03 1996-03-05 Pope; Edward J. A. Sensor incorporating an optical fiber and a solid porous inorganic microsphere
GB9401833D0 (en) 1994-02-01 1994-03-30 Isis Innovation Method for discovering ligands
EP0754240B1 (en) 1994-02-07 2003-08-20 Beckman Coulter, Inc. Ligase/polymerase-mediated genetic bit analysis of single nucleotide polymorphisms and its use in genetic analysis
US6090555A (en) * 1997-12-11 2000-07-18 Affymetrix, Inc. Scanned image alignment systems and methods
US5468649A (en) 1994-02-15 1995-11-21 Abbott Laboratories Process for labeling acridinium to microparticles and application in an instrument
IL108726A (en) 1994-02-22 1999-12-31 Yissum Res Dev Co Electrobiochemical method and system for the determination of an analyte which is a member of a recognition pair in a liquid medium and electrodes therefor
GB9404709D0 (en) 1994-03-11 1994-04-27 Multilyte Ltd Binding assay
US5599666A (en) 1994-03-28 1997-02-04 Promega Corporation Allelic ladders for short tandem repeat loci
IL109240A (en) 1994-04-07 1998-02-22 Yeda Res & Dev Ion exchange membranes
US5602042A (en) 1994-04-14 1997-02-11 Cytyc Corporation Method and apparatus for magnetically separating biological particles from a mixture
US5571639A (en) 1994-05-24 1996-11-05 Affymax Technologies N.V. Computer-aided engineering system for design of sequence arrays and lithographic masks
US5549974A (en) * 1994-06-23 1996-08-27 Affymax Technologies Nv Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof
DE4421901A1 (en) 1994-06-23 1996-01-04 Bayer Ag A rapid DNA test for the detection of quinolone-resistant Staphylococcus aureus pathogens in clinical specimens
US5763198A (en) 1994-07-22 1998-06-09 Sugen, Inc. Screening assays for compounds
AU2990595A (en) 1994-07-26 1996-02-22 Sydney Brenner Multidimensional conduit combinatorial library synthesis device
US6001229A (en) 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
US5512490A (en) 1994-08-11 1996-04-30 Trustees Of Tufts College Optical sensor, optical sensing apparatus, and methods for detecting an analyte of interest using spectral recognition patterns
US5582988A (en) 1994-09-15 1996-12-10 Johnson & Johnson Clinical Diagnostics, Inc. Methods for capture and selective release of nucleic acids using weakly basic polymer and amplification of same
US5705628A (en) 1994-09-20 1998-01-06 Whitehead Institute For Biomedical Research DNA purification and isolation using magnetic particles
CA2118048C (en) 1994-09-30 2003-04-08 James W. Schumm Multiplex amplification of short tandem repeat loci
US5843660A (en) 1994-09-30 1998-12-01 Promega Corporation Multiplex amplification of short tandem repeat loci
JP2792532B2 (en) 1994-09-30 1998-09-03 日本電気株式会社 Semiconductor device manufacturing method and semiconductor wafer
US6103379A (en) 1994-10-06 2000-08-15 Bar-Ilan University Process for the preparation of microspheres and microspheres made thereby
US5604097A (en) 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
US5846719A (en) 1994-10-13 1998-12-08 Lynx Therapeutics, Inc. Oligonucleotide tags for sorting and identification
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
EP1489550B1 (en) 1994-10-25 2011-07-20 United Parcel Service Of America, Inc. Automatic electronic camera for label image capture
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
GB2295152A (en) 1994-11-18 1996-05-22 Pfizer Ltd Preparation of a library of compounds by solid-phase synthesis
US5527710A (en) * 1994-12-02 1996-06-18 Igen, Inc. Rate measurements of biomolecular reactions using electrochemiluminescence
US5789147A (en) 1994-12-05 1998-08-04 New York Blood Center, Inc. Method for concentrating white cells from whole blood by adding a red cell sedimentation reagent to whole anticoagulated blood
KR0158780B1 (en) * 1994-12-22 1998-11-16 가네꼬 히사시 Method and apparatus for film formation by chemical vapor deposition
US5567304A (en) 1995-01-03 1996-10-22 Ibm Corporation Elimination of island formation and contact resistance problems during electroetching of blanket or patterned thin metallic layers on insulating substrate
GB9501221D0 (en) 1995-01-21 1995-03-15 Carnaudmetalbox Technology Plc Continuity tester and method
US5834590A (en) 1995-02-22 1998-11-10 Eastern Virginia Medical School Of The Medical College Of Hampton Roads Ingap protein involved in pancreatic islet neogenesis
US5959098A (en) 1996-04-17 1999-09-28 Affymetrix, Inc. Substrate preparation process
US6207369B1 (en) * 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
US6066448A (en) 1995-03-10 2000-05-23 Meso Sclae Technologies, Llc. Multi-array, multi-specific electrochemiluminescence testing
AU5110096A (en) 1995-03-28 1996-10-16 Novartis Ag Process for the production of combinatorial compound libraries
GB9507238D0 (en) 1995-04-07 1995-05-31 Isis Innovation Detecting dna sequence variations
US5751629A (en) 1995-04-25 1998-05-12 Irori Remotely programmable matrices with memories
US5741462A (en) * 1995-04-25 1998-04-21 Irori Remotely programmable matrices with memories
US5961923A (en) 1995-04-25 1999-10-05 Irori Matrices with memories and uses thereof
US5690894A (en) 1995-05-23 1997-11-25 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
DE69632324T2 (en) 1995-06-07 2005-06-16 PerSeptive Biosystems, Inc., Framingham PNA-DNA CHIMESES AND PNA SYNTHESES FOR THEIR PREPARATION
EP0832287B1 (en) 1995-06-07 2007-10-10 Solexa, Inc Oligonucleotide tags for sorting and identification
EP0830594A1 (en) * 1995-06-08 1998-03-25 Visible Genetics Inc. Nanofabricated separation matrix for analysis of biopolymers and methods of making and using same
US5716852A (en) 1996-03-29 1998-02-10 University Of Washington Microfabricated diffusion-based chemical sensor
US5728529A (en) 1995-06-23 1998-03-17 Baylor College Of Medicine Alternative dye-labeled ribonucleotides, deoxyribonucleotides, and dideoxyribonucleotides for automated DNA analysis
JP2965131B2 (en) 1995-07-07 1999-10-18 東洋紡績株式会社 Magnetic carrier for nucleic acid binding and nucleic acid isolation method using the same
US6515649B1 (en) 1995-07-20 2003-02-04 E Ink Corporation Suspended particle displays and materials for making the same
DE19528029B4 (en) 1995-07-31 2008-01-10 Chemagen Biopolymer-Technologie Aktiengesellschaft Magnetic polymer particles based on polyvinyl alcohol, process for their preparation and use
US6107462A (en) 1995-08-17 2000-08-22 The Regents Of The University Of California Genes and proteins controlling cholesterol synthesis
US5660990A (en) 1995-08-18 1997-08-26 Immunivest Corporation Surface immobilization of magnetically collected materials
US6200737B1 (en) 1995-08-24 2001-03-13 Trustees Of Tufts College Photodeposition method for fabricating a three-dimensional, patterned polymer microstructure
US5633724A (en) 1995-08-29 1997-05-27 Hewlett-Packard Company Evanescent scanning of biochemical array
US5994066A (en) 1995-09-11 1999-11-30 Infectio Diagnostic, Inc. Species-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories
US5981180A (en) 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
DE69638321D1 (en) 1995-10-11 2011-03-03 Luminex Corp SIMULTANEOUS MULTI-ANALYSIS OF CLINICAL SAMPLES
US5866331A (en) * 1995-10-20 1999-02-02 University Of Massachusetts Single molecule detection by in situ hybridization
US5744299A (en) 1995-11-03 1998-04-28 Mcw Research Foundation Human parainfluenza virus-1 assay
US6015664A (en) 1995-11-03 2000-01-18 Mcw Research Foundation Multiplex PCR assay using unequal primer concentrations to detect HPIV 1,2,3 and RSV A,B and influenza virus A, B
US5722470A (en) * 1995-11-09 1998-03-03 Glaxo Group Limited Bead dispensing device and methods
US5763175A (en) * 1995-11-17 1998-06-09 Lynx Therapeutics, Inc. Simultaneous sequencing of tagged polynucleotides
US5763263A (en) * 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
US5633972A (en) 1995-11-29 1997-05-27 Trustees Of Tufts College Superresolution imaging fiber for subwavelength light energy generation and near-field optical microscopy
US5814524A (en) 1995-12-14 1998-09-29 Trustees Of Tufts College Optical sensor apparatus for far-field viewing and making optical analytical measurements at remote locations
US6156502A (en) 1995-12-21 2000-12-05 Beattie; Kenneth Loren Arbitrary sequence oligonucleotide fingerprinting
US20010018514A1 (en) 1998-07-31 2001-08-30 Mcgall Glenn H. Nucleic acid labeling compounds
US5766963A (en) * 1996-01-26 1998-06-16 Pharmacopeia, Inc. Combination hydroxypropylamine library
DE29601618U1 (en) 1996-01-31 1996-07-04 Invitek Gmbh Multiple simultaneous isolation device
US5723233A (en) * 1996-02-27 1998-03-03 Lsi Logic Corporation Optical proximity correction method and apparatus
AT403745B (en) * 1996-02-29 1998-05-25 Avl Verbrennungskraft Messtech MEASURING ARRANGEMENT WITH A TRANSPARENT ELEMENT FOR EXCITING AND MEASURING RADIATION
WO1997032226A1 (en) 1996-02-29 1997-09-04 Minnesota Mining And Manufacturing Company Brightness enhancement film
US6297062B1 (en) * 1996-03-07 2001-10-02 Bio-Magnetics Ltd. Separation by magnetic particles
US5747349A (en) 1996-03-20 1998-05-05 University Of Washington Fluorescent reporter beads for fluid analysis
US6193866B1 (en) 1996-03-27 2001-02-27 Curagen Corporation Separation of charged particles by a spatially and temporally varying electric field
US5663724A (en) 1996-03-28 1997-09-02 Seagate Technology, Inc. 16B/20B encoder
US6074609A (en) 1996-04-24 2000-06-13 Glaxo Wellcome Inc. Systems for arraying beads
US6958245B2 (en) 1996-04-25 2005-10-25 Bioarray Solutions Ltd. Array cytometry
ES2288760T3 (en) 1996-04-25 2008-01-16 Bioarray Solutions Ltd. ELECTROCINETIC ASSEMBLY CONTROLLED BY LIGHT OF PARTICLES NEXT TO SURFACES.
US7144119B2 (en) 1996-04-25 2006-12-05 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US6387707B1 (en) 1996-04-25 2002-05-14 Bioarray Solutions Array Cytometry
US7041510B2 (en) 1996-04-25 2006-05-09 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US6083699A (en) 1996-05-01 2000-07-04 Visible Genetics Inc. Method for bi-directional sequencing of nucleic acid polymers
US5900949A (en) 1996-05-23 1999-05-04 Hewlett-Packard Company CCD imager for confocal scanning microscopy
JP3445455B2 (en) * 1996-05-24 2003-09-08 ペンタックス株式会社 Image recording device
EP0912761A4 (en) 1996-05-29 2004-06-09 Cornell Res Foundation Inc Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
US5989835A (en) 1997-02-27 1999-11-23 Cellomics, Inc. System for cell-based screening
NZ333346A (en) 1996-06-28 2000-03-27 Caliper Techn Corp High-throughput screening assay systems in microscale fluidic devices
NL1003570C2 (en) 1996-07-11 1998-01-15 Stichting Centraal Lab Method for antigen and antibody determination in blood group serology.
US6075905A (en) 1996-07-17 2000-06-13 Sarnoff Corporation Method and apparatus for mosaic image construction
WO1998004950A1 (en) 1996-07-25 1998-02-05 Anvik Corporation Seamless, maskless lithography system using spatial light modulator
US6312134B1 (en) 1996-07-25 2001-11-06 Anvik Corporation Seamless, maskless lithography system using spatial light modulator
GB9615775D0 (en) 1996-07-26 1996-09-04 British Tech Group Apparatus and method for characterising particles using dielectrophoresis
US6506564B1 (en) 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
BR9706597A (en) 1996-08-01 1999-07-20 Loctite Ireland Ltd Process for forming a monolayer of particles and products formed in this way
AU709730B2 (en) 1996-08-02 1999-09-02 Dionex Corporation Electromigration injection from a microreservoir-electrode in capillary separation systems
US5831046A (en) 1996-08-05 1998-11-03 Prolinx, Incorporated Boronic acid-contaning nucleic acid monomers
US5792430A (en) 1996-08-12 1998-08-11 Monsanto Company Solid phase organic synthesis device with pressure-regulated manifold
US6203993B1 (en) 1996-08-14 2001-03-20 Exact Science Corp. Methods for the detection of nucleic acids
DE19633997C1 (en) 1996-08-23 1998-03-26 Univ Stuttgart Remote image inspection facility for image transmission
US5766711A (en) 1996-08-29 1998-06-16 Barmakian; Andrew Composite camel structure and method for manufacture
US6120666A (en) 1996-09-26 2000-09-19 Ut-Battelle, Llc Microfabricated device and method for multiplexed electrokinetic focusing of fluid streams and a transport cytometry method using same
US6124092A (en) 1996-10-04 2000-09-26 The Perkin-Elmer Corporation Multiplex polynucleotide capture methods and compositions
US6209589B1 (en) 1996-10-21 2001-04-03 Smithkline Beecham Plc Apparatus and method for distributing beads
US5786219A (en) 1996-10-28 1998-07-28 Molecular Probes, Inc. Microspheres with fluorescent spherical zones
US6018350A (en) * 1996-10-29 2000-01-25 Real 3D, Inc. Illumination and shadow simulation in a computer graphics/imaging system
CA2189486A1 (en) 1996-11-04 1998-05-04 Yves St-Pierre Analysis of enzyme activity using immobilized fluorescence-labeled substrates
US6133436A (en) * 1996-11-06 2000-10-17 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
US5900481A (en) 1996-11-06 1999-05-04 Sequenom, Inc. Bead linkers for immobilizing nucleic acids to solid supports
US20020031841A1 (en) 1996-11-06 2002-03-14 Asher Sanford A. Colorimetric reagent
US5965235A (en) 1996-11-08 1999-10-12 The Procter & Gamble Co. Three-dimensional, amorphous-patterned, nesting-resistant sheet materials and method and apparatus for making same
US5776711A (en) 1996-11-12 1998-07-07 The Regents Of The University Of California Simultaneous human ABO and RH(D) blood typing or antibody screening by flow cytometry
US5855753A (en) * 1996-11-26 1999-01-05 The Trustees Of Princeton University Method for electrohydrodynamically assembling patterned colloidal structures
CA2271717A1 (en) 1996-12-12 1998-06-18 Prolume, Ltd. Apparatus and method for detecting and identifying infectious agents
US5905024A (en) 1996-12-17 1999-05-18 University Of Chicago Method for performing site-specific affinity fractionation for use in DNA sequencing
CA2276462C (en) 1996-12-31 2007-06-12 Genometrix Incorporated Multiplexed molecular analysis system apparatus and method
US6025905A (en) * 1996-12-31 2000-02-15 Cognex Corporation System for obtaining a uniform illumination reflectance image during periodic structured illumination
US6100030A (en) 1997-01-10 2000-08-08 Pioneer Hi-Bred International, Inc. Use of selective DNA fragment amplification products for hybridization-based genetic fingerprinting, marker assisted selection, and high-throughput screening
US6027945A (en) 1997-01-21 2000-02-22 Promega Corporation Methods of isolating biological target materials using silica magnetic particles
US5939021A (en) 1997-01-23 1999-08-17 Hansen; W. Peter Homogeneous binding assay
US5812272A (en) 1997-01-30 1998-09-22 Hewlett-Packard Company Apparatus and method with tiled light source array for integrated assay sensing
JP3630906B2 (en) 1997-02-18 2005-03-23 キヤノン株式会社 Stereoscopic image display device
EP0975800B1 (en) 1997-02-27 2003-05-21 Ingeneus Corp. Assaying nucleotides in solution using pna probes
US6023540A (en) 1997-03-14 2000-02-08 Trustees Of Tufts College Fiber optic sensor with encoded microspheres
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
WO1998042725A1 (en) 1997-03-21 1998-10-01 Musc Foundation For Research Development Methods and compositions for diagnosis and treatment of breast cancer
US6235471B1 (en) 1997-04-04 2001-05-22 Caliper Technologies Corp. Closed-loop biochemical analyzers
EP0979071B1 (en) 1997-04-30 2007-11-07 Point Biomedical Corporation Microparticles useful as ultrasonic contrast agents and for delivery of drugs into the bloodstream
US6106685A (en) 1997-05-13 2000-08-22 Sarnoff Corporation Electrode combinations for pumping fluids
EP0985142A4 (en) 1997-05-23 2006-09-13 Lynx Therapeutics Inc System and apparaus for sequential processing of analytes
EP1003904B1 (en) 1997-05-23 2007-07-11 BioArray Solutions Ltd. Color-encoding and in-situ interrogation of matrix-coupled chemical compounds
US5948627A (en) 1997-05-30 1999-09-07 One Lambda Immunobead flow cytometric detection of anti-HLA panel-reactive antibody
US5876946A (en) 1997-06-03 1999-03-02 Pharmacopeia, Inc. High-throughput assay
DE69833758T2 (en) 1997-06-13 2006-08-31 Affymetrix, Inc. (n.d.Ges.d.Staates Delaware), Santa Clara METHOD FOR DETECTING GENE POLYMORPHISMS AND ALLELEXPRESSION USING PROBE CHIPS
US6060243A (en) 1997-07-17 2000-05-09 Procrea Biosciences Inc. Primers for obtaining highly informative DNA markers
WO1999009217A1 (en) 1997-08-15 1999-02-25 Hyseq, Inc. Methods and compositions for detection or quantification of nucleic acid species
US7099777B1 (en) 1997-09-05 2006-08-29 Affymetrix, Inc. Techniques for identifying confirming mapping and categorizing nucleic acids
US6130101A (en) 1997-09-23 2000-10-10 Molecular Probes, Inc. Sulfonated xanthene derivatives
US6540895B1 (en) 1997-09-23 2003-04-01 California Institute Of Technology Microfabricated cell sorter for chemical and biological materials
US5948621A (en) 1997-09-30 1999-09-07 The United States Of America As Represented By The Secretary Of The Navy Direct molecular patterning using a micro-stamp gel
US7115884B1 (en) 1997-10-06 2006-10-03 Trustees Of Tufts College Self-encoding fiber optic sensor
WO1999019515A1 (en) 1997-10-14 1999-04-22 Luminex Corporation Precision fluorescently dyed particles and methods of making and using same
US6014451A (en) 1997-10-17 2000-01-11 Pioneer Hi-Bred International, Inc. Remote imaging system for plant diagnosis
US6077669A (en) 1997-11-04 2000-06-20 Becton Dickinson And Company Kit and method for fluorescence based detection assay
US5922617A (en) 1997-11-12 1999-07-13 Functional Genetics, Inc. Rapid screening assay methods and devices
CA2260991C (en) 1997-11-18 2009-03-24 Bio-Rad Laboratories, Inc. Multiplex flow immunoassays with magnetic particles as solid phase
US6013449A (en) 1997-11-26 2000-01-11 The United States Of America As Represented By The Department Of Health And Human Services Probe-based analysis of heterozygous mutations using two-color labelling
US6232066B1 (en) 1997-12-19 2001-05-15 Neogen, Inc. High throughput assay system
DE69832817T2 (en) 1997-12-30 2006-09-14 Jose Remacle PROCESS WITH INFLAMMAGE TIED ON A DISC SURFACE
AU2322099A (en) 1998-01-16 1999-08-02 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
US6167910B1 (en) 1998-01-20 2001-01-02 Caliper Technologies Corp. Multi-layer microfluidic devices
US6200814B1 (en) 1998-01-20 2001-03-13 Biacore Ab Method and device for laminar flow on a sensing surface
ATE239801T1 (en) 1998-01-22 2003-05-15 Luminex Corp MICROPARTICLES WITH MULTIPLE FLUORESCENCE SIGNALS
US6123263A (en) 1998-01-29 2000-09-26 Meta Holdings Corporation Hand held dataform reader having strobing ultraviolet light illumination assembly for reading fluorescent dataforms
US6238863B1 (en) 1998-02-04 2001-05-29 Promega Corporation Materials and methods for indentifying and analyzing intermediate tandem repeat DNA markers
CA2318880C (en) 1998-02-04 2010-07-27 Perkin-Elmer Corporation Determination of a genotype of an amplification product at multiple allelic sites
US5994079A (en) 1998-02-06 1999-11-30 Digene Corporation Direct detection of RNA mediated by reverse transcriptase lacking RNAse H function
US6349144B1 (en) * 1998-02-07 2002-02-19 Biodiscovery, Inc. Automated DNA array segmentation and analysis
CA2320390C (en) 1998-02-11 2010-06-08 Perkin-Elmer Corporation Pna and dna conjugates and methods for preparation thereof
US6122599A (en) 1998-02-13 2000-09-19 Mehta; Shailesh Apparatus and method for analyzing particles
US6096368A (en) 1998-02-19 2000-08-01 Delsys Pharmaceutical Corporation Bead transporter chucks using repulsive field guidance and method
GB9803684D0 (en) 1998-02-24 1998-04-15 Genevac Ltd Method and apparatus for controlling temperature during evaporation of samples
US6318970B1 (en) 1998-03-12 2001-11-20 Micralyne Inc. Fluidic devices
US5988432A (en) 1998-03-25 1999-11-23 Sarnoff Corporation Bead manipulating chucks with bead size selector
IL138668A0 (en) 1998-04-03 2001-10-31 Phylos Inc Addressable protein arrays
DE19815129A1 (en) 1998-04-03 1999-10-07 Basf Ag Precipitated, water-insoluble dyes in colloidally dispersed form
US6022716A (en) 1998-04-10 2000-02-08 Genset Sa High throughput DNA sequencing vector
US5952131A (en) 1998-04-27 1999-09-14 Xerox Corporation Core and shell matrix compositions and processes
US6355419B1 (en) 1998-04-27 2002-03-12 Hyseq, Inc. Preparation of pools of nucleic acids based on representation in a sample
US20030087228A1 (en) 1998-05-06 2003-05-08 Cynthia Bamdad Electronic detection of nucleic acids using monolayers
AU4194899A (en) 1998-05-21 1999-12-06 Hyseq, Inc. Linear arrays of immobilized compounds and methods of using same
US6251592B1 (en) 1998-05-26 2001-06-26 Procrea Biosciences Inc. STR marker system for DNA fingerprinting
US6139831A (en) 1998-05-28 2000-10-31 The Rockfeller University Apparatus and method for immobilizing molecules onto a substrate
US6699659B2 (en) 1998-06-01 2004-03-02 Affymetrix, Inc. Products and methods for analyzing nucleic acids including identification of substitutions, insertions and deletions
US6251595B1 (en) 1998-06-18 2001-06-26 Agilent Technologies, Inc. Methods and devices for carrying out chemical reactions
US6290839B1 (en) 1998-06-23 2001-09-18 Clinical Micro Sensors, Inc. Systems for electrophoretic transport and detection of analytes
EP1090293B2 (en) 1998-06-24 2019-01-23 Illumina, Inc. Decoding of array sensors with microspheres
WO2000001850A2 (en) 1998-07-02 2000-01-13 Gen-Probe Incorporated Molecular torches
AR020329A1 (en) 1998-07-09 2002-05-08 Boehringer Ingelheim Pharma A SUBSTANCE, IN PARTICULAR A RIBOZIMA, IS ABLE TO INHIBIT THE PRESENILINE EXPRESSION 2, A RECOMBINATING MOLECULA OF DNA THAT CODIFY SUCH RIBOZIMA, A RECOMBINATING UNVECTOR THAT UNDERSTANDS THE CORRECTING CELL TO A RIBO BELLING ONE.
US6406921B1 (en) 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6908770B1 (en) 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
US5998175A (en) 1998-07-24 1999-12-07 Lumigen, Inc. Methods of synthesizing and amplifying polynucleotides by ligation of multiple oligomers
DE69800630T2 (en) 1998-07-29 2001-08-23 Agilent Technologies Inc Chip for electrophoretic separation of molecules and method for using the same
WO2000007019A1 (en) 1998-07-30 2000-02-10 Amdex A/S Method for preparing water-soluble cross-linked conjugates
US6132685A (en) 1998-08-10 2000-10-17 Caliper Technologies Corporation High throughput microfluidic systems and methods
US6035547A (en) * 1998-08-17 2000-03-14 Chrysler Corporation Water-borne basecoat flash process
US6126731A (en) 1998-08-21 2000-10-03 Idea Development Company Polymerizable ink composition
US6306643B1 (en) 1998-08-24 2001-10-23 Affymetrix, Inc. Methods of using an array of pooled probes in genetic analysis
US6136468A (en) 1998-08-25 2000-10-24 Timer Technologies, Llc Electrochemical cell with deferred assembly
AU6131299A (en) 1998-08-26 2000-03-21 Trustees Of Tufts College Combinatorial polymer synthesis of sensors for polymer-based sensor arrays
JP3829491B2 (en) 1998-08-27 2006-10-04 株式会社日立製作所 Probe tip, probe tip creation method, sample detection method, and sample detection device
WO2000013018A2 (en) 1998-08-28 2000-03-09 Febit Ferrarius Biotechnology Gmbh Support for a method for determining analytes and a method for producing the support
US6642062B2 (en) 1998-09-03 2003-11-04 Trellis Bioinformatics, Inc. Multihued labels
US6136171A (en) 1998-09-18 2000-10-24 The University Of Utah Research Foundation Micromachined electrical field-flow fractionation system
WO2000020593A1 (en) 1998-10-02 2000-04-13 Eli Lilly And Company Il-17 homolog nucleic acids, polypeptides, vectors, host cells, methods and uses thereof
AU1115200A (en) 1998-10-13 2000-05-01 Clontech Laboratories, Inc. Nucleic acid arrays
US6480791B1 (en) 1998-10-28 2002-11-12 Michael P. Strathmann Parallel methods for genomic analysis
US6452851B1 (en) 1998-10-29 2002-09-17 Hitachi, Ltd. Semiconductor integrated circuit device
US6187540B1 (en) 1998-11-09 2001-02-13 Identigene, Inc. Method of newborn identification and tracking
US20030012699A1 (en) 1998-11-18 2003-01-16 Thomas Moore Simultaneous handling of magnetic beads in a two-dimensional arrangement
US6271856B1 (en) * 1998-11-19 2001-08-07 Paraform, Inc. Creating and modifying parameterizations of surfaces
GB9825958D0 (en) 1998-11-26 1999-01-20 Smith James L Load-bearing structures
US6872546B1 (en) 1998-12-23 2005-03-29 Human Genome Sciences, Inc. Hyaluronan-binding proteins and encoding genes
US6429027B1 (en) 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
US6534293B1 (en) 1999-01-06 2003-03-18 Cornell Research Foundation, Inc. Accelerating identification of single nucleotide polymorphisms and alignment of clones in genomic sequencing
EP1151139A2 (en) 1999-01-25 2001-11-07 UT-Battelle, LLC Multifunctional and multispectral biosensor devices and methods of use
JP3756007B2 (en) 1999-01-28 2006-03-15 富士写真フイルム株式会社 Dry analysis method and dry analysis element
DE19904674A1 (en) 1999-02-04 2000-08-31 Haemosys Gmbh Method for determining the concentration of thrombin inhibitors
US20020150909A1 (en) 1999-02-09 2002-10-17 Stuelpnagel John R. Automated information processing in randomly ordered arrays
US6294063B1 (en) 1999-02-12 2001-09-25 Board Of Regents, The University Of Texas System Method and apparatus for programmable fluidic processing
US6153389A (en) 1999-02-22 2000-11-28 Haarer; Brian K. DNA additives as a mechanism for unambiguously marking biological samples
US6215894B1 (en) 1999-02-26 2001-04-10 General Scanning, Incorporated Automatic imaging and analysis of microarray biochips
CN1185492C (en) 1999-03-15 2005-01-19 清华大学 Single-point strobed micro electromagnetic units array chip or electromagnetic biologic chip and application thereof
US6403309B1 (en) 1999-03-19 2002-06-11 Valigen (Us), Inc. Methods for detection of nucleic acid polymorphisms using peptide-labeled oligonucleotides and antibody arrays
AU778438B2 (en) * 1999-04-06 2004-12-02 Yale University Fixed address analysis of sequence tags
DE19916921A1 (en) 1999-04-14 2000-10-19 Fraunhofer Ges Forschung Electrical sensor array
US6908737B2 (en) 1999-04-15 2005-06-21 Vitra Bioscience, Inc. Systems and methods of conducting multiplexed experiments
US6355431B1 (en) 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
US6858403B2 (en) 1999-05-11 2005-02-22 M-Biotech, Inc. Polymer matrix containing catalase co-immobilized with analytic enzyme that generates hydrogen peroxide
IT1309430B1 (en) 1999-05-18 2002-01-23 Guerrieri Roberto METHOD AND APPARATUS FOR HANDLING PARTICLES BY MEANS OF ELECTROPHORESIS
EP1190100B1 (en) 1999-05-20 2012-07-25 Illumina, Inc. Combinatorial decoding of random nucleic acid arrays
US6132997A (en) 1999-05-28 2000-10-17 Agilent Technologies Method for linear mRNA amplification
CA2309528C (en) 1999-06-08 2007-10-09 Ortho-Clinical Diagnostics, Inc. Simultaneous determination of forward and reverse abo blood group
AU5600300A (en) 1999-06-25 2001-01-31 Gim Systems Ltd. Scanning microscope by lcd
AU5785400A (en) 1999-07-02 2001-01-22 Symyx Technologies, Inc. Polymer brushes for immobilizing molecules to a surface or substrate, where the polymers have water-soluble or water-dispersible segments and probes bonded thereto
US6303316B1 (en) 1999-07-02 2001-10-16 Conceptual Mind Works, Inc. Organic semiconductor recognition complex and system
US6268219B1 (en) 1999-07-09 2001-07-31 Orchid Biosciences, Inc. Method and apparatus for distributing fluid in a microfluidic device
KR100677860B1 (en) 1999-07-23 2007-02-05 보드 오브 트러스티스 오브 유니버스티 오브 일리노이즈 Microfabricated Devices and Method of Manufacturing The Same
US20020015952A1 (en) 1999-07-30 2002-02-07 Anderson Norman G. Microarrays and their manufacture by slicing
US6713309B1 (en) 1999-07-30 2004-03-30 Large Scale Proteomics Corporation Microarrays and their manufacture
AU2246601A (en) * 1999-08-30 2001-04-10 Illumina, Inc. Methods for improving signal detection from an array
BE1012894A3 (en) 1999-09-14 2001-05-08 Atlas Copco Airpower Nv Combined radial-axial sliding bearing
US6319674B1 (en) 1999-09-16 2001-11-20 Agilent Technologies, Inc. Methods for attaching substances to surfaces
US6844156B2 (en) 1999-10-19 2005-01-18 The United States Of America As Represented By The Department Of Veterans Affairs Methods for identifying a preferred liver transplant donor
US6287778B1 (en) 1999-10-19 2001-09-11 Affymetrix, Inc. Allele detection using primer extension with sequence-coded identity tags
US6077674A (en) 1999-10-27 2000-06-20 Agilent Technologies Inc. Method of producing oligonucleotide arrays with features of high purity
AU1601701A (en) 1999-11-15 2001-05-30 John G. Hartwell Methods for generating single stranded cdna fragments
US6451191B1 (en) 1999-11-18 2002-09-17 3M Innovative Properties Company Film based addressable programmable electronic matrix articles and methods of manufacturing and using the same
US6605453B2 (en) * 1999-12-01 2003-08-12 The Regents Of The University Of California Electric-field-assisted fluidic assembly of inorganic and organic materials, molecules and like small things including living cells
US6361916B1 (en) 1999-12-14 2002-03-26 Eastman Kodak Company Loaded latex compositions with dye and stabilizer
US20020007122A1 (en) 1999-12-15 2002-01-17 Howard Kaufman Methods of diagnosing disease
US6500620B2 (en) 1999-12-29 2002-12-31 Mergen Ltd. Methods for amplifying and detecting multiple polynucleotides on a solid phase support
EP1252196B1 (en) 2000-01-05 2005-11-02 Novartis AG Hydrogels
EP1246699B1 (en) 2000-01-11 2007-01-03 Clinical Micro Sensors, Inc. Cartridge comprising a biochip
EP1252513A4 (en) 2000-01-25 2007-07-18 Affymetrix Inc Method, system and computer software for providing a genomic web portal
ATE354334T1 (en) 2000-02-02 2007-03-15 Procter & Gamble FLEXIBLE MANUFACTURING SYSTEM
EP1255865B1 (en) 2000-02-07 2007-04-18 Illumina, Inc. Nucleic acid detection method using universal priming
EP1990428B1 (en) 2000-02-07 2010-12-22 Illumina, Inc. Nucleic acid detection methods using universal priming
AU2001239760B2 (en) 2000-02-10 2005-11-24 Illumina, Inc. Array of individual arrays as substrate for bead-based simultaneous processing of samples and manufacturing method therefor
US7003144B2 (en) * 2000-02-11 2006-02-21 The United States Of America As Represented By The Department Of Health And Human Services Vessel delineation in magnetic resonance angiographic images
EP1130113A1 (en) 2000-02-15 2001-09-05 Johannes Petrus Schouten Multiplex ligation dependent amplification assay
US6993156B1 (en) 2000-02-18 2006-01-31 Microsoft Corporation System and method for statistically comparing and matching plural sets of digital data
US20030154108A1 (en) 2000-03-01 2003-08-14 Gambro, Inc. Extracorporeal blood processing information management system
EP1238361A1 (en) 2000-03-01 2002-09-11 Gambro, Inc. Extracorporeal blood processing information management system
US6358387B1 (en) 2000-03-27 2002-03-19 Caliper Technologies Corporation Ultra high throughput microfluidic analytical systems and methods
AU4989501A (en) * 2000-04-06 2001-10-23 Luminex Corp Magnetically-responsive microspheres
DE10020704B4 (en) 2000-04-27 2006-09-28 Bioref Gmbh Biochip for archiving and laboratory medical analysis of biological sample material, process for its production and its use in diagnostic procedures
US7682837B2 (en) 2000-05-05 2010-03-23 Board Of Trustees Of Leland Stanford Junior University Devices and methods to form a randomly ordered array of magnetic beads and uses thereof
EP2565826B1 (en) 2000-05-11 2019-11-06 Becton Dickinson and Company System for indentifying clusters in scatter plots using smoothed polygons with optimal boundaries
US20040009614A1 (en) 2000-05-12 2004-01-15 Ahn Chong H Magnetic bead-based arrays
DK1132739T3 (en) 2000-05-16 2002-01-28 Biochip Technologies Gmbh Linker system for activating surfaces for bioconjugation and methods for using them
US6645432B1 (en) 2000-05-25 2003-11-11 President & Fellows Of Harvard College Microfluidic systems including three-dimensionally arrayed channel networks
DE10027776A1 (en) 2000-06-07 2002-02-14 Roche Diagnostics Gmbh Novel core-shell particles
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
ES2259666T3 (en) 2000-06-21 2006-10-16 Bioarray Solutions Ltd MOLECULAR ANALYSIS OF MULTIPLE ANALYTICS USING SERIES OF RANDOM PARTICLES WITH APPLICATION SPECIFICITY.
JP4233238B2 (en) 2000-07-06 2009-03-04 富士フイルム株式会社 Colored fine particle dispersion for ink, ink for ink jet recording using the same, and ink jet recording method
DE10042023C2 (en) 2000-08-08 2003-04-10 Biognostic Ag Capsules that encapsulate solid particles of signal-generating substances and their use in bioassays for the detection of target molecules in a sample
EP1314035A1 (en) 2000-08-14 2003-05-28 Surface Logix, Inc. Pathways arrays
EP1337670A4 (en) 2000-08-16 2004-07-14 Whatman Inc Transfusion medicine leukodepletion filter devices as a source of genetic material for genotyping studies
US20020182609A1 (en) 2000-08-16 2002-12-05 Luminex Corporation Microsphere based oligonucleotide ligation assays, kits, and methods of use, including high-throughput genotyping
US7062092B2 (en) 2000-08-22 2006-06-13 Affymetrix, Inc. System, method, and computer software product for gain adjustment in biological microarray scanner
JP2004512533A (en) 2000-08-22 2004-04-22 アフィメトリックス インコーポレイテッド Systems, methods and computer software products for controlling biological microarray scanners
US7998746B2 (en) * 2000-08-24 2011-08-16 Robert Otillar Systems and methods for localizing and analyzing samples on a bio-sensor chip
US6713257B2 (en) 2000-08-25 2004-03-30 Rosetta Inpharmatics Llc Gene discovery using microarrays
US6521747B2 (en) 2000-08-28 2003-02-18 Genaissance Pharmaceuticals, Inc. Haplotypes of the AGTR1 gene
US7057704B2 (en) 2000-09-17 2006-06-06 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US6498863B1 (en) 2000-09-20 2002-12-24 Media Cybernetics Inc. Method, system, and product for analyzing a digitized image of an array to create an image of a grid overlay
AU2001294699A1 (en) 2000-09-23 2002-04-29 New York Blood Center Identification of the dombrock blood group glycoprotein as a polymorphic member of the adp-ribosyltransferase gene family
WO2002031501A1 (en) 2000-10-12 2002-04-18 Amnis Corporation Methods for synthesizing reporter labeled beads
WO2002031182A2 (en) 2000-10-12 2002-04-18 Amnis Corporation Method and apparatus for reading reporter labeled beads
US20030045005A1 (en) * 2000-10-17 2003-03-06 Michael Seul Light-controlled electrokinetic assembly of particles near surfaces
US7130458B2 (en) * 2000-10-24 2006-10-31 Affymetrix, Inc. Computer software system, method, and product for scanned image alignment
US6528264B1 (en) 2000-11-01 2003-03-04 Corning Incorporated Polymer support for DNA immobilization
AU2001213911A1 (en) 2000-11-02 2002-05-15 Jandratek Gmbh Surfaces comprising a hydrophilic spacer, covalently bonded to hydrogels
US20020137074A1 (en) 2000-11-21 2002-09-26 Piunno Paul A.E. Selectivity of nucleic acid diagnostic and microarray technologies by control of interfacial nucleic acid film chemistry
FR2817266B1 (en) 2000-11-29 2004-01-16 Commissariat Energie Atomique MICRO STATIC NETWORK OF BIOLOGICAL OR CHEMICAL PROBES, IMMOBILIZED ON A MAGNETIC ATTRACTION SUPPORT
US6905881B2 (en) 2000-11-30 2005-06-14 Paul Sammak Microbead-based test plates and test methods for fluorescence imaging systems
US20020081027A1 (en) 2000-12-21 2002-06-27 Motorola, Inc. Method for electronic transport of digital ink
WO2002057496A2 (en) 2001-01-18 2002-07-25 Socratech L.L.C. Gene expression profiling of endothelium in alzheimer's disease
US7015047B2 (en) 2001-01-26 2006-03-21 Aviva Biosciences Corporation Microdevices having a preferential axis of magnetization and uses thereof
US20030165865A1 (en) 2001-01-29 2003-09-04 Hinkel Christopher A. Methods of analysis of nucleic acids
US6681788B2 (en) 2001-01-29 2004-01-27 Caliper Technologies Corp. Non-mechanical valves for fluidic systems
US7407746B2 (en) 2001-02-08 2008-08-05 Ngk Insulators, Ltd. Biochip and method for producing the same
AU2002252297A1 (en) 2001-03-10 2002-09-24 Bioinformatics Dna Codes, Llc Methods and tools for nucleic acid sequence analysis selection and generation
US6706163B2 (en) 2001-03-21 2004-03-16 Michael Seul On-chip analysis of particles and fractionation of particle mixtures using light-controlled electrokinetic assembly of particles near surfaces
EP1379693B1 (en) 2001-03-28 2009-05-20 Nanosphere, Inc. Bio-barcodes based on oligonucleotide-modified particles
US20020142318A1 (en) 2001-03-30 2002-10-03 Cattell Herbert F. Chemical array reading
AU2002245988A1 (en) 2001-04-18 2002-10-28 Ulrich J. Krull Gradient resolved hybridisation platform
GB0110053D0 (en) 2001-04-24 2001-06-13 Axis Shield Asa Assay
JP3761418B2 (en) 2001-05-10 2006-03-29 Hoya株式会社 Compound crystal and process for producing the same
US6808908B2 (en) 2001-05-30 2004-10-26 Porex Technologies Corporation Functionalized porous substrate for binding chemical and biological moieties
US6689478B2 (en) 2001-06-21 2004-02-10 Corning Incorporated Polyanion/polycation multilayer film for DNA immobilization
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
US7172804B2 (en) 2001-07-17 2007-02-06 Northwestern University Film-immobilized capture particles
US7285412B2 (en) 2001-07-27 2007-10-23 Surface Logix Inc. Device for magnetic immobilization of cells
US20030040129A1 (en) 2001-08-20 2003-02-27 Shah Haresh P. Binding assays using magnetically immobilized arrays
US6503680B1 (en) 2001-08-29 2003-01-07 Xerox Corporation Latex processes
WO2003020968A2 (en) 2001-08-29 2003-03-13 Genovoxx Gmbh Method for analyzing nucleic acid sequences and gene expression
US20030062422A1 (en) * 2001-09-10 2003-04-03 Fateley William G. System and method for encoded spatio-spectral information processing
JP4685294B2 (en) 2001-09-18 2011-05-18 株式会社カネカ Novel peptide, production method, novel adsorbent, adsorber and adsorption method
US7195913B2 (en) 2001-10-05 2007-03-27 Surmodics, Inc. Randomly ordered arrays and methods of making and using
WO2003031591A2 (en) 2001-10-10 2003-04-17 Superarray Bioscience Corporation Detecting targets by unique identifier nucleotide tags
EP2722395B1 (en) 2001-10-15 2018-12-19 Bioarray Solutions Ltd Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection
US6927018B2 (en) 2001-10-29 2005-08-09 Hewlett-Packard Development Company, L.P. Three dimensional printing using photo-activated building materials
WO2003038558A2 (en) 2001-10-30 2003-05-08 Nanomics Biosystems Pty, Ltd. Device and methods for directed synthesis of chemical libraries
US6838289B2 (en) 2001-11-14 2005-01-04 Beckman Coulter, Inc. Analyte detection system
US6792355B2 (en) 2001-12-21 2004-09-14 Triad Therapeutics, Inc. Methods for determining polypeptide structure, function or pharmacophore from comparison of polypeptide sequences
US7335153B2 (en) 2001-12-28 2008-02-26 Bio Array Solutions Ltd. Arrays of microparticles and methods of preparation thereof
DE10164309A1 (en) 2001-12-28 2003-07-10 Fraunhofer Ges Forschung Improved structured-functional binding matrices for biomolecules
US20030152931A1 (en) 2002-02-11 2003-08-14 Chung-Fan Chiou Nucleic acid detection device and method utilizing the same
JP2003263507A (en) 2002-03-12 2003-09-19 Nippon Colin Co Ltd Method and device for providing statistical medical information
US20030186220A1 (en) 2002-03-28 2003-10-02 Jizhong Zhou Detecting microorganisms using whole genomic DNA or RNA microarray
AU2003231229A1 (en) 2002-04-30 2003-11-17 Cook Biotech Incorporated Sling for supporting tissue
US6730515B2 (en) 2002-06-11 2004-05-04 Eastman Kodak Company Micro-array calibration means
US7041453B2 (en) 2002-08-22 2006-05-09 Bioarray Solutions Ltd. Molecular constructs and methods of use for detection of biochemical reactions
US7157228B2 (en) 2002-09-09 2007-01-02 Bioarray Solutions Ltd. Genetic analysis and authentication
DE10246285B4 (en) 2002-10-02 2007-10-04 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Arrangement and method for loading a loading space with piece goods
US7401028B2 (en) 2002-11-08 2008-07-15 Deakter Daniel R System and process for matching patients with clinical medical trials
WO2004047007A1 (en) 2002-11-15 2004-06-03 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
US7141217B2 (en) 2002-12-05 2006-11-28 Uop Llc Elevated pressure apparatus and method for generating a plurality of isolated effluents
US6869798B2 (en) 2003-04-17 2005-03-22 Clinical Diagnostics Solutions, Inc. Lytic reagent composition for leukocyte differential analysis
US20040229269A1 (en) 2003-05-15 2004-11-18 Ghazala Hashmi Hybridization-mediated analysis of polymorphisms
US20040259852A1 (en) 2003-06-18 2004-12-23 White Hillary D. Trandsdermal compositions and methods for treatment of fibromyalgia and chronic fatigue syndrome
ES2375962T3 (en) 2003-09-22 2012-03-07 Bioarray Solutions Ltd IMMOBILIZED SURFACE POLYELECTROLYTE WITH MULTIPLE FUNCTIONAL GROUPS ABLE TO JOIN COVALENTLY TO BIOMOLECULES.
WO2005033895A2 (en) 2003-10-03 2005-04-14 Cira Discovery Sciences, Inc. Method and apparatus for discovering patterns in binary or categorical data
US20050089916A1 (en) 2003-10-28 2005-04-28 Xiongwu Xia Allele assignment and probe selection in multiplexed assays of polymorphic targets
WO2005043117A2 (en) 2003-10-28 2005-05-12 Bioarray Solutions Ltd. Gel-shell beads with adsorbed or bound biomolecules
EP1692298A4 (en) 2003-10-28 2008-08-13 Bioarray Solutions Ltd Optimization of gene expression analysis using immobilized capture probes
ES2533876T3 (en) 2003-10-29 2015-04-15 Bioarray Solutions Ltd Multiplexed nucleic acid analysis by double stranded DNA fragmentation
US20050112585A1 (en) 2003-11-21 2005-05-26 Dominic Zichi Method for adjusting the quantification range of individual analytes in a multiplexed assay
US20080261205A1 (en) 2004-02-06 2008-10-23 Canadian Blood Services Method for the Simultaneous Determination of Blood Group and Platelet Antigen Genotypes
US20050191682A1 (en) 2004-02-17 2005-09-01 Affymetrix, Inc. Methods for fragmenting DNA
WO2005081908A2 (en) 2004-02-20 2005-09-09 The Trustees Of The University Of Pennsyvania Reagents, kits and methods for immunodetection of epitopes on molecules
EP1591534A1 (en) 2004-04-01 2005-11-02 Stichting Sanquin Bloedvoorziening A method of genotyping blood cell antigens and a kit suitable for genotyping blood cell antigens
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US7501253B2 (en) 2004-09-21 2009-03-10 The Board Of Trustees Of The Leland Stanford Junior University DNA fingerprinting using a branch migration assay
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
NZ567403A (en) 2005-10-07 2011-03-31 Johnson & Johnson Res Pty Ltd Multicomponent nucleic acid enzymes and methods for their use
US20070243534A1 (en) 2006-04-12 2007-10-18 Michael Seul Probe density considerations and elongation of self-complementary looped probes where probes are attached to a solid phase
CN100466552C (en) 2006-09-28 2009-03-04 华为技术有限公司 NGN system and end to end tracing method and device applied in this system
WO2009088893A1 (en) 2008-01-11 2009-07-16 Recommended Reading, Inc. Data picker application
US7812589B2 (en) 2008-08-28 2010-10-12 Qualitau, Inc. Modified current source (MCS) with seamless range switching
DE102008045650A1 (en) 2008-09-02 2010-03-04 Siemens Aktiengesellschaft Track and busbar system in flat profile design with several sub-conductor rails with recess on the narrow side for engaging contact spring elements
US20100062518A1 (en) 2008-09-09 2010-03-11 Sukanta Banerjee Concentrating White Blood Cells for DNA Extraction from a Leukodepleted Blood Sample
WO2010098765A1 (en) 2009-02-27 2010-09-02 Leslie Cifuentes French Dispenser and applicator that bring reactive substances into contact with each other at the time of use
JP4617386B2 (en) 2009-06-11 2011-01-26 シャープ株式会社 Steam cooker

Also Published As

Publication number Publication date
US7749774B2 (en) 2010-07-06
JP4034351B2 (en) 2008-01-16
DE69737883D1 (en) 2007-08-16
US20070259449A1 (en) 2007-11-08
US20070082412A9 (en) 2007-04-12
WO1997040385A1 (en) 1997-10-30
US20060040411A1 (en) 2006-02-23
EP0907889B1 (en) 2007-07-04
ATE366418T1 (en) 2007-07-15
US6514771B1 (en) 2003-02-04
US20140262782A1 (en) 2014-09-18
US8309368B2 (en) 2012-11-13
US6991941B1 (en) 2006-01-31
US20080038844A1 (en) 2008-02-14
US8071393B2 (en) 2011-12-06
US20070154934A1 (en) 2007-07-05
US7090759B1 (en) 2006-08-15
US6955751B1 (en) 2005-10-18
US20130123146A1 (en) 2013-05-16
EP2290364A1 (en) 2011-03-02
JP2001500961A (en) 2001-01-23
US6468811B1 (en) 2002-10-22
US8691594B2 (en) 2014-04-08
US6797524B1 (en) 2004-09-28
US9400259B2 (en) 2016-07-26
US6251691B1 (en) 2001-06-26
US20060228741A1 (en) 2006-10-12
ES2288760T3 (en) 2008-01-16
DE69737883T2 (en) 2008-03-06
US7615345B2 (en) 2009-11-10
US20040037744A1 (en) 2004-02-26
EP0907889A4 (en) 2002-11-06
US8039271B2 (en) 2011-10-18
EP0907889A1 (en) 1999-04-14
US20170014794A1 (en) 2017-01-19
US7427512B2 (en) 2008-09-23
US20060228739A1 (en) 2006-10-12
CA2255599C (en) 2006-09-05

Similar Documents

Publication Publication Date Title
CA2255599A1 (en) Light-controlled electrokinetic assembly of particles near surfaces
CA2441194A1 (en) Analysis and fractionation of particles near surfaces
CA2332775A1 (en) Electrophoresis apparatus and method
ATE307878T1 (en) ELECTROSPRAY ASSEMBLY FOR INTRODUCTION OF MATERIAL INTO CELLS
EP0376611A3 (en) Electrophoretic system
KR970707599A (en) Organic fuel cell, method of operating same, and method of manufacturing electrode for same (Organic fuel cell, and methods of operation the electrode and manufacture of electrode therefor)
CA2482546A1 (en) Sampling probe microarray read out using electrospray mass spectrometry
JPS646755A (en) Chromatography support body for oligonucleotide separation
DE68915014T2 (en) Device for forming thin layers and an ion source operating by microwave atomization.
GB9000050D0 (en) Process for dispersing organic pigments with ultrasonic radiation
US5837116A (en) Two dimensional electrophoresis apparatus
DE4217868A1 (en) Temp.-controlled multiple test tube for optical study of liquids - has upper and lower aluminium plates having openings into which test tubes are placed at least one plate has surface foil heating element
EP0380414A3 (en) Method for analysing the relaxation spectra and the resonances in materials
AU4979290A (en) Reagent for immunoassay and device using the same
CA2164015A1 (en) Coated carrier particles and processes thereof
AU691563B2 (en) Sample holder and method for automated high throughput electrophoresis
GB9018334D0 (en) Process,specimen and device for making an analyte available for an investigation
AU2034999A (en) Pipetting devices preloaded with standardized control sample materials
AU584790B2 (en) Reciprocating electrode cleaner for electric field liquid treater
WO2007025507A1 (en) System for two-dimensional (2d) gel electrophoresis
CA2278009A1 (en) Method for determining materials conversion in electrochemical reactions and electrochemical unit
AU8799798A (en) Cross-linkable liquid silicon rubber mixtures, method for the production thereof, method for producing electrically conductive contact points and the use thereof
WO2000002039A1 (en) Method and device for separating biomolecules
AU2255897A (en) Pipetting devices preloaded with standardized control sample materials
DE59410376D1 (en) Process for the non-destructive examination of surfaces of electrically conductive materials

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20170424