CA2255614A1 - Dha-pharmaceutical agent conjugates - Google Patents

Dha-pharmaceutical agent conjugates

Info

Publication number
CA2255614A1
CA2255614A1 CA002255614A CA2255614A CA2255614A1 CA 2255614 A1 CA2255614 A1 CA 2255614A1 CA 002255614 A CA002255614 A CA 002255614A CA 2255614 A CA2255614 A CA 2255614A CA 2255614 A1 CA2255614 A1 CA 2255614A1
Authority
CA
Canada
Prior art keywords
tissue
conjugate
condition
agent
pharmaceutical agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002255614A
Other languages
French (fr)
Other versions
CA2255614C (en
Inventor
Matthews O. Bradley
Victor E. Shashoua
Nigel L. Webb
Charles S. Swindell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
American Regent Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2255614A1 publication Critical patent/CA2255614A1/en
Application granted granted Critical
Publication of CA2255614C publication Critical patent/CA2255614C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

The invention provides conjugates of cis-docosahexaenoic acid and pharmaceutical agents useful in treating noncentral nervous system conditions. Methods for selectively targeting pharmaceutical agents to desired tissues are provided.

Claims (21)

1. A method for targeting a pharmaceutical agent to a noncentral nervous system tissue to treat a noncentral nervous system condition comprising:
administering to a subject in need of such treatment a covalent conjugate of cis-docosahexaenoic acid and a pharmaceutical agent effective for treating said condition.
2. The method of claim 1, wherein the cis-docosahexaenoic acid is conjugated directly to the pharmaceutical agent.
3. The method of claim 2, wherein the tissue is breast tissue and wherein the subject has a condition calling for treatment of breast tissue with the pharmaceutical agent.
4. The method of claim 2, wherein the tissue is gastrointestinal tissue and wherein the subject has a condition calling for treatment of gastrointestinal tissue with the pharmaceutical agent.
5. The method of claim 2, wherein the tissue is ovarian tissue and wherein the subject has a condition calling for treatment of ovarian tissue with the pharmaceutical agent.
6. The method of claim 2, wherein the pharmaceutical agent is a noncentral nervous system active agent that is nonactive within the central nervous system.
7. The method of claim 2, wherein the drug is an anti-cancer agent.
8. The method of claim 7, wherein the drug is Taxol.
9. The method of claim 8, wherein the conjugate is
10. The method of claim 8, wherein the conjugate is
11. The method of claim 7, wherein the drug is Taxotere.
12. The method of claim 11, wherein the conjugate is
13. The method of claim 11, wherein the conjugate is
14. The method of claim 11, wherein the conjugate is
15. The method of claim 11, wherein the conjugate is
16. The method of claim 1, 2, 3, 6, 7, 8, 9, 10, 11, 12, 13, 14 or 15, wherein the condition is breast cancer.
17. The method of claim 1, 2, 3, 6, 7, 8, 9, 10, 11, 12, 13, 14 or 15. wherein the condition is colon cancer.
18. The method of claim 1, 2, 3, 6, 7, 8, 9, 10, 11, 12, 13, 14 or 15, wherein the condition is ovarian cancer.
19. A pharmaceutical preparation comprising:
a covalent conjugate of cis-docosahexaenoic acid and a noncentral nervous systemactive agent, and a pharmaceutically acceptable carrier.
20. The pharmaceutical preparation of claim 19, wherein the cis-docosahexaenoic acid is conjugated directly to the active agent.
21. The pharmaceutical preparation as claimed in claim 20, wherein the noncentral nervous system active agent is active on a tissue selected from the group consisting of:Blood and Blood Forming tissue; Cardiovascular system tissue; Digestive and excretory system tissue; Endocrine system tissue; Musclar system tissue; Reproductive System tissue; Respiratory system tissue; Skeletal system tissue; and Fiber and integumentary system tissue.
CA002255614A 1996-05-22 1997-05-22 Dha-pharmaceutical agent conjugates Expired - Fee Related CA2255614C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/651,312 US5795909A (en) 1996-05-22 1996-05-22 DHA-pharmaceutical agent conjugates of taxanes
US08/651,312 1996-05-22
PCT/US1997/008867 WO1997044063A2 (en) 1996-05-22 1997-05-22 Dha-pharmaceutical agent conjugates

Publications (2)

Publication Number Publication Date
CA2255614A1 true CA2255614A1 (en) 1997-11-27
CA2255614C CA2255614C (en) 2009-12-15

Family

ID=24612392

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002255614A Expired - Fee Related CA2255614C (en) 1996-05-22 1997-05-22 Dha-pharmaceutical agent conjugates

Country Status (10)

Country Link
US (3) US5795909A (en)
EP (2) EP1466628A1 (en)
JP (1) JP4402173B2 (en)
AT (1) ATE273025T1 (en)
AU (1) AU725759B2 (en)
CA (1) CA2255614C (en)
DE (1) DE69730217T2 (en)
DK (1) DK0909183T3 (en)
ES (1) ES2222514T3 (en)
WO (1) WO1997044063A2 (en)

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