CA2256582A1 - Oxa acids and related compounds for treating skin conditions - Google Patents

Oxa acids and related compounds for treating skin conditions

Info

Publication number
CA2256582A1
CA2256582A1 CA002256582A CA2256582A CA2256582A1 CA 2256582 A1 CA2256582 A1 CA 2256582A1 CA 002256582 A CA002256582 A CA 002256582A CA 2256582 A CA2256582 A CA 2256582A CA 2256582 A1 CA2256582 A1 CA 2256582A1
Authority
CA
Canada
Prior art keywords
skin conditions
treating skin
related compounds
compounds
oxa acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002256582A
Other languages
French (fr)
Other versions
CA2256582C (en
Inventor
Dmitri Ptchelintsev
Neil Scancarella
Robert Kalafsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Avon Products Inc
Original Assignee
Avon Products, Inc.
Dmitri Ptchelintsev
Neil Scancarella
Robert Kalafsky
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avon Products, Inc., Dmitri Ptchelintsev, Neil Scancarella, Robert Kalafsky filed Critical Avon Products, Inc.
Publication of CA2256582A1 publication Critical patent/CA2256582A1/en
Application granted granted Critical
Publication of CA2256582C publication Critical patent/CA2256582C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/006—Antidandruff preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/24—Thermal properties
    • A61K2800/244—Endothermic; Cooling; Cooling sensation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/12—Preparations containing hair conditioners

Abstract

The present invention is directed to the use of compounds of formula (I), depicted above, as active principals for treating skin conditions; compositions containing these compounds; and methods of treating skin conditions using these compounds and compositions.
In said formula (I), R4 is (CR5R6-CR7R8-X1)n-CR9R10R11, n is an integer from 1 to 18; R1, R2, R3, R5, R6, R7, R8, R9, R10 and R11 are independently, hydrogen or non-hydrogen substituents; and X, X1, Y and Z are independently O, NH, or S.
CA002256582A 1996-06-04 1997-06-02 Oxa acids and related compounds for treating skin conditions Expired - Lifetime CA2256582C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/658,089 1996-06-04
US08/658,089 US5847003A (en) 1996-06-04 1996-06-04 Oxa acids and related compounds for treating skin conditions
PCT/US1997/009281 WO1997046231A1 (en) 1996-06-04 1997-06-02 Oxa acids and related compounds for treating skin conditions

Publications (2)

Publication Number Publication Date
CA2256582A1 true CA2256582A1 (en) 1997-12-11
CA2256582C CA2256582C (en) 2008-08-12

Family

ID=24639855

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002256582A Expired - Lifetime CA2256582C (en) 1996-06-04 1997-06-02 Oxa acids and related compounds for treating skin conditions

Country Status (11)

Country Link
US (5) US5847003A (en)
EP (1) EP0910362B1 (en)
JP (2) JPH1072334A (en)
CN (1) CN1110302C (en)
AR (1) AR008384A1 (en)
AT (1) ATE280577T1 (en)
BR (1) BR9709427B1 (en)
CA (1) CA2256582C (en)
DE (1) DE69731385T2 (en)
HK (1) HK1020167A1 (en)
WO (1) WO1997046231A1 (en)

Families Citing this family (114)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5874463A (en) * 1994-10-24 1999-02-23 Ancira; Margaret Hydroxy-kojic acid skin peel
FR2730930B1 (en) * 1995-02-27 1997-04-04 Oreal USE OF NO-SYNTHASE INHIBITORS TO REDUCE THE IRRITANT SKIN EFFECT OF PRODUCTS USED IN THE COSMETIC OR PHARMACEUTICAL FIELD
US5932229A (en) * 1996-04-25 1999-08-03 Avon Products, Inc. Oxa diacids and related compounds for treating skin conditions
US5965618A (en) * 1997-11-17 1999-10-12 Perricone; Nicholas V. Treatment of scar tissue using lipoic acid
ATE336992T1 (en) * 1998-02-13 2006-09-15 Carol J Buck USE OF COMPOSITIONS CONTAINING ALKANEOUS ACIDS FOR THE TREATMENT OF NAIL FUNGUS DISEASES
AU2904899A (en) * 1998-03-16 1999-10-11 Procter & Gamble Company, The Compositions for regulating skin appearance
US6136339A (en) * 1998-08-21 2000-10-24 Gardiner; Paul T. Food supplements and methods comprising lipoic acid and creatine
US6607716B1 (en) 1998-09-29 2003-08-19 Tech Labs, Inc. Pediculicidal compositions, a kit, and methods of use
US7396526B1 (en) 1998-11-12 2008-07-08 Johnson & Johnson Consumer Companies, Inc. Skin care composition
US6521237B2 (en) * 1998-11-12 2003-02-18 Johnson & Johnson Consumer Companies, Inc. Skin care composition
US6765019B1 (en) * 1999-05-06 2004-07-20 University Of Kentucky Research Foundation Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids
US6242491B1 (en) * 1999-06-25 2001-06-05 Rima Kaddurah-Daouk Use of creatine or creatine compounds for skin preservation
US6696078B1 (en) * 1999-07-21 2004-02-24 Edwin J. Masters System and methods for local intradermal treatment
US6309662B1 (en) 1999-09-23 2001-10-30 Janet Buchanan Use of anti-inflammatory drugs for treatment of dermatological conditions
US6358517B1 (en) 1999-10-22 2002-03-19 Unilever Home & Personal Care Usa, Division Of Conopco Cosmetic compositions containing resveratrol and retinoids
US6277362B1 (en) 1999-10-26 2001-08-21 Isw, Inc. After shave treatment preparation
US6562368B2 (en) * 1999-12-16 2003-05-13 Dermatrends, Inc. Transdermal administration of oxybutynin using hydroxide-releasing agents as permeation enhancers
US6582724B2 (en) 1999-12-16 2003-06-24 Dermatrends, Inc. Dual enhancer composition for topical and transdermal drug delivery
US6562369B2 (en) * 1999-12-16 2003-05-13 Dermatrends, Inc. Transdermal administration of androgenic drugs hydroxide-releasing agents as permeation enhancers
US20030104041A1 (en) * 1999-12-16 2003-06-05 Tsung-Min Hsu Transdermal and topical administration of drugs using basic permeation enhancers
US6673363B2 (en) 1999-12-16 2004-01-06 Dermatrends, Inc. Transdermal and topical administration of local anesthetic agents using basic enhancers
US6586000B2 (en) * 1999-12-16 2003-07-01 Dermatrends, Inc. Hydroxide-releasing agents as skin permeation enhancers
US6558695B2 (en) * 1999-12-16 2003-05-06 Dermatrends, Inc. Topical and transdermal administration of peptidyl drugs using hydroxide releasing agents as permeation enhancers
US6645520B2 (en) * 1999-12-16 2003-11-11 Dermatrends, Inc. Transdermal administration of nonsteroidal anti-inflammatory drugs using hydroxide-releasing agents as permeation enhancers
US20030072724A1 (en) * 1999-12-16 2003-04-17 Maibach Howard I. Topical pharmaceutical composition to treat hyperpigmentation of the skin
US6562370B2 (en) * 1999-12-16 2003-05-13 Dermatrends, Inc. Transdermal administration of steroid drugs using hydroxide-releasing agents as permeation enhancers
US6565879B1 (en) 1999-12-16 2003-05-20 Dermatrends, Inc. Topical and transdermal administration of peptidyl drugs with hydroxide-releasing agents as skin permeation enhancers
CA2401340A1 (en) * 2000-02-28 2001-09-07 The University Of British Columbia Compositions and methods for the treatment of inflammatory disease using topoisomerase inhibitors
FR2811567B1 (en) * 2000-07-13 2003-01-17 Oreal COMPOSITION, ESPECIALLY COSMETIC, COMPRISING DHEA AND / OR A PRECURSOR OR DERIVATIVE THEREOF, IN ASSOCIATION WITH AT LEAST ONE NO-SYNTHASE INHIBITOR
FR2812812B1 (en) * 2000-08-08 2002-10-11 Philippe Gorny MEDICINE INTENDED IN PARTICULAR TO COMBAT SEXUAL DYSFUNCTIONS
JP3573287B2 (en) * 2000-08-08 2004-10-06 第一製薬株式会社 Super absorbent solid preparation
US20030095991A1 (en) * 2000-10-02 2003-05-22 Curtis Cole Treatment for skin
US20040213754A1 (en) * 2000-10-02 2004-10-28 Cole Curtis A. Method for cleansing sensitive skin using an alkanolamine
KR20020027198A (en) * 2000-10-02 2002-04-13 차알스 제이. 메츠 Method for reduction of inflammation and erythema
US20040067245A1 (en) 2000-12-20 2004-04-08 Harish Mahalingam Cosmetic compositions and methods for using same to improve the aesthetic appearance of skin
US6565864B2 (en) 2000-12-28 2003-05-20 Unilever Home & Personal Care Usa, A Division Of Conopco, Inc. Skin care product containing retinoids and phytoestrogens in a dual compartment package
EP1234572B1 (en) * 2001-02-26 2013-10-30 Mibelle AG Cosmetics Skin treatment compositions containing isoflavone aglycones
DE10111040A1 (en) * 2001-03-06 2002-09-12 Beiersdorf Ag Use of combinations of alpha-lipoic acid and ultraviolet absorbers for treating inflammatory skin disorders or protecting sensitive dry skin
DE10111046A1 (en) * 2001-03-06 2002-09-12 Beiersdorf Ag Cosmetic or dermatological preparations for treating or preventing pigmentation disorders, e.g. freckles or liver spots, containing active agent combination of alpha-lipoic acid and UV-A or UV-B absorber
WO2002096374A2 (en) * 2001-05-31 2002-12-05 Upsher-Smith Laboratories, Inc. Dermatological compositions and methods comprising alpha-hydroxy acids or derivatives
US6419940B1 (en) * 2001-08-14 2002-07-16 Denver Blanton Denver's sting stopper
US6514508B1 (en) * 2001-08-24 2003-02-04 Jeffrey Rose Itch reducing device and method
US6641824B2 (en) * 2001-11-09 2003-11-04 Avon Products, Inc. Skin treatment using a new retinoid
US20050238730A1 (en) * 2001-11-21 2005-10-27 Agnes Le Fur Compositions comprising an ethanolamine derivative and organic metal salts
AU2002366451A1 (en) * 2001-12-19 2003-09-09 Alwyn Company, Inc. Emulsified skin care composition containing salicylic acid, lanolin oil, and propylene glycol
US20030180250A1 (en) * 2002-03-22 2003-09-25 Council Of Scientific And Industrial Research Compositions and complexes containing a macromolecular compound as potential anti-inflammatory agents
US6835385B2 (en) 2002-06-14 2004-12-28 Carol J. Buck Compositions and methods for softening, thinning and removing hyperkeratotic tissue
US6858215B2 (en) 2002-06-14 2005-02-22 Carol J. Buck Compositions and methods for softening, thinning and removing hyperkeratotic tissue
AU2002331892A1 (en) * 2002-06-21 2004-01-06 Dermatrends, Inc. Topical pharmaceutical composition to treat hyperpigmentation of the skin
KR20040043703A (en) * 2002-11-16 2004-05-27 (주)라렌드몽드 Retinoid containing chemical peeling agent
US7060303B2 (en) * 2002-12-31 2006-06-13 Avon Products, Inc. Use of purslane to treat facial wrinkles
US7304202B2 (en) 2002-12-31 2007-12-04 Ossur Hf Wound dressing
US6866856B2 (en) * 2002-12-31 2005-03-15 Avon Products, Inc. Compositions and delivery methods for the treatment of wrinkles, fine lines and hyperhidrosis
EP1648396A2 (en) * 2003-05-23 2006-04-26 Ninapharm (S.A.R.L) Product for epidermal protection
US7085154B2 (en) * 2003-06-03 2006-08-01 Samsung Electronics Co., Ltd. Device and method for pulse width control in a phase change memory device
US7531711B2 (en) 2003-09-17 2009-05-12 Ossur Hf Wound dressing and method for manufacturing the same
CA2539945C (en) 2003-09-17 2015-04-21 Ossur Hf Wound dressing and method for manufacturing the same
US7205006B2 (en) * 2003-09-25 2007-04-17 Prime Pharmaceutical Corporation Mahonia aquifolium extract, extraction process and pharmaceutical composition containing the same
US7504385B2 (en) * 2003-12-17 2009-03-17 Avon Products, Inc. si-RNA-mediated gene silencing technology to inhibit tyrosinase and reduce pigmentation
EP1747033A1 (en) 2004-04-30 2007-01-31 Burrell E. Clawson Apparatus and methods for isolating human body areas for localized cooling
US20060040002A1 (en) * 2004-08-17 2006-02-23 Boitano Suzanne M Anti-itch composition
US8221766B2 (en) * 2004-12-22 2012-07-17 Avon Products, Inc. Use of plant extracts to prevent and/or reduce the signs of subjective discomfort and/or irritation in the topical application of cosmetic products
US7514092B2 (en) 2004-12-22 2009-04-07 Avon Products, Inc. Compositions and methods of their use for improving the condition and appearance of skin
US7410658B2 (en) * 2004-12-22 2008-08-12 Avon Products, Inc. Use of Alisma orientale in cosmetics and compositions thereof
US7351745B2 (en) 2004-12-22 2008-04-01 Avon Products, Inc Compositions and methods of their use for improving the condition and appearance of skin
US7618662B2 (en) * 2004-12-22 2009-11-17 Avon Products, Inc Use of natural plant extracts in cosmetic compositions
US7161056B2 (en) * 2005-01-28 2007-01-09 Ossur Hf Wound dressing and method for manufacturing the same
US20060235370A1 (en) * 2005-04-04 2006-10-19 Oblong John E Method of regulating mammalian keratinous tissue
WO2006138056A1 (en) * 2005-06-15 2006-12-28 Apollo Pharmaceutical, Inc. Pharmaceutical composition comprising a mahonia aquifolium extract for the treatment of psoriasis
US20070027152A1 (en) * 2005-07-27 2007-02-01 Clark Kathleen L Topical anti-pruritic compositions and methods of action of same
US20070027153A1 (en) * 2005-07-27 2007-02-01 Reeth Kevin M Topical skin-protectant and anti-pruritic compositions
US7989554B2 (en) * 2006-01-10 2011-08-02 Enzon Pharmaceuticals, Inc. Reacting polyalkylene oxide with base, tertiary alkyl haloacetate, then acid to prepare polyalkylene oxide carboxylic acid
FR2908307B1 (en) * 2006-11-10 2009-05-01 Oreal COSMETIC COMPOSITION COMPRISING AN ALKYL PHOSPHATE AND A FATTY ALCOHOL ETHER AND POLYETHYLENE GLYCOL, METHODS AND USES.
MY151457A (en) * 2006-11-15 2014-05-30 Arthritis Relief Plus Ltd Topical formulation and uses thereof
US20080220026A1 (en) * 2007-03-06 2008-09-11 Prithwiraj Maitra Mesoporous material compositions and methods of their use for improving the appearance of biological surfaces
US7642062B2 (en) 2006-12-29 2010-01-05 Avon Products Inc. Compositions and methods of their use for improving the condition and appearance of skin
US8586012B2 (en) 2007-06-06 2013-11-19 Solise LLC Body wash with sunscreen system and method
US20080311058A1 (en) * 2007-06-18 2008-12-18 Connopco, Inc., D/B/A Unilever Stable high internal phase emulsions and compositions comprising the same
WO2009002913A1 (en) * 2007-06-22 2008-12-31 Avicena Group, Inc. Use of creatine compounds to treat dermatitis
RS52576B (en) * 2007-11-07 2013-04-30 Gojko DUNKIĆ Chemical preparation for gradual removal of benign lesions and procedure for its application on facial, head and body skin
ES2336995B1 (en) * 2008-10-13 2011-02-09 Lipotec, S.A. COSMETIC OR DERMOPHARMACEUTICAL COMPOSITION FOR SKIN CARE, HAIR LEATHER AND NAILS.
US8299127B2 (en) * 2009-03-11 2012-10-30 Conopco, Inc. Method and composition for evenly applying water soluble actives
US8206691B2 (en) 2009-11-04 2012-06-26 Conopco, Inc. Sunscreen composition with fatty acid alkanolamides
US8173108B2 (en) 2009-11-04 2012-05-08 Conopco, Inc. Sunscreen composition
WO2011082044A1 (en) * 2009-12-30 2011-07-07 Avon Products, Inc. Topical lightening composition and uses thereof
CA2799083C (en) 2010-06-30 2018-04-24 Avon Products, Inc. Use of tiliacora triandra in cosmetics and compositions thereof
PL2588593T3 (en) 2010-06-30 2018-01-31 Avon Prod Inc Compositions and methods for stimulating magp-1 to improve the appearance of skin
US8821839B2 (en) 2010-10-22 2014-09-02 Conopco, Inc. Compositions and methods for imparting a sunless tan with a vicinal diamine
US8398959B2 (en) 2010-12-06 2013-03-19 Conopco, Inc. Compositions and methods for imparting a sunless tan with functionalized adjuvants
EP2723452A2 (en) 2011-06-22 2014-04-30 Vyome Biosciences Pvt Ltd Conjugate-based antifungal and antibacterial prodrugs
CN103826702B (en) 2011-09-26 2017-02-15 荷兰联合利华有限公司 Hair composition
US8961942B2 (en) 2011-12-13 2015-02-24 Conopco, Inc. Sunless tanning compositions with adjuvants comprising sulfur comprising moieties
US9259343B2 (en) 2012-07-06 2016-02-16 Newman Technologies LLC Device for mitigating plantar fasciitis
EP2855619B1 (en) * 2012-07-26 2019-04-17 Amril AG Esters for drilling emulsions and metal working fluids
CA2914583C (en) 2013-06-04 2019-06-18 Vyome Biosciences Pvt. Ltd. Coated particles and compositions comprising same
ES2539520B1 (en) * 2013-12-30 2016-06-06 Laboratorios Viñas S.A. Topical application pharmaceutical composition in the form of a micronized suspension and corresponding method and uses
US9642788B2 (en) 2014-04-25 2017-05-09 The Procter & Gamble Company Shampoo composition comprising gel matrix and histidine
US9642787B2 (en) 2014-04-25 2017-05-09 The Procter & Gamble Company Method of inhibiting copper deposition on hair
US9586063B2 (en) 2014-04-25 2017-03-07 The Procter & Gamble Company Method of inhibiting copper deposition on hair
AU2016346203B2 (en) 2015-10-30 2021-05-27 Leo Pharma A/S Isotretinoin formulations and uses and methods thereof
JP2019508411A (en) * 2016-02-11 2019-03-28 オハイオ ユニバーシティ Compositions and methods for inhibiting UVB radiation injury by targeting constitutive nitric oxide synthase (cNOS)
EP3441382B1 (en) 2016-04-05 2023-08-30 Moresco Corporation Oxa acid compound
US11246816B2 (en) 2016-06-30 2022-02-15 The Procter And Gamble Company Shampoo compositions comprising a chelant
US11786447B2 (en) 2016-06-30 2023-10-17 The Procter & Gamble Company Conditioner composition comprising a chelant
US20180000705A1 (en) 2016-06-30 2018-01-04 The Procter & Gamble Company Shampoo Compositions Comprising a Chelant
US20180000715A1 (en) 2016-06-30 2018-01-04 The Procter & Gamble Company Hair Care Compositions For Calcium Chelation
US20180000706A1 (en) * 2016-06-30 2018-01-04 The Procter & Gamble Company Conditioner Composition Comprising a Chelant
BE1025004B1 (en) 2017-02-24 2018-09-24 Oystershell Nv PELTABLE NAIL POLISH
WO2018202832A1 (en) 2017-05-05 2018-11-08 Firmenich Sa Organic hydroperoxide reduction in perfumery raw materials and food raw materials
US10966948B2 (en) 2019-07-23 2021-04-06 Johnson & Johnson Surgical Vision, Inc. Compositions and methods for treating the eye
KR20210038636A (en) 2018-07-27 2021-04-07 존슨 앤드 존슨 서지컬 비전, 인코포레이티드 Composition and method for eye treatment
US11197841B2 (en) 2019-07-23 2021-12-14 Johnson & Johnson Surgical Vision, Inc. Compositions and methods for treating the eye
US20230346664A1 (en) * 2022-04-28 2023-11-02 L'oreal Compositions suitable as setters
NL2035417A (en) 2022-07-19 2024-01-26 Coty Inc Cosmetic composition

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3342858A (en) * 1964-08-20 1967-09-19 Allied Chem Preparation of alkoxy-alkanoic acids by the oxidation of alkoxy-alkanols
DE2404047A1 (en) * 1974-01-29 1975-08-14 Henkel & Cie Gmbh SKIN CARE AND SKIN PROTECTION PRODUCTS WITH A CONTENT OF SKIN MOISTURIZERS
GB1541463A (en) * 1975-10-11 1979-02-28 Lion Dentifrice Co Ltd Process for prparing a multiple emulsion having a dispersing form of water-phase/oil-phase/water-phase
DE2714564C2 (en) * 1977-04-01 1986-01-02 Chemische Werke Hüls AG, 4370 Marl Process for the preparation of cyclic diesters of undecanedioic acid
US4386104A (en) * 1977-04-19 1983-05-31 Nazzaro Porro Marcella Process for the treatment of acne
IT1114950B (en) * 1977-12-30 1986-02-03 Porro Marcella COMPOSITIONS FOR ACNE TREATMENT AND THERAPY
DE2936123A1 (en) * 1979-09-07 1981-04-02 Hoechst Ag, 6000 Frankfurt METHOD FOR PRODUCING ALKOXY ACETIC ACIDS
US4721579A (en) * 1980-08-15 1988-01-26 Basf Corporation Sodium carboxymethyl derivatives of polyoxyalkylene glycols, their production, and use in functional fluids
US4766153A (en) * 1986-04-30 1988-08-23 Sandoz Ltd. Alkyl polyoxyalkylene carboxylate esters and skin care compositions containing the same
DE3640708C2 (en) * 1986-11-28 1995-05-18 Schering Ag Improved pharmaceuticals containing metals
US5091171B2 (en) * 1986-12-23 1997-07-15 Tristrata Inc Amphoteric compositions and polymeric forms of alpha hydroxyacids and their therapeutic use
US4960764A (en) * 1987-03-06 1990-10-02 Richardson-Vicks Inc. Oil-in-water-in-silicone emulsion compositions
US4885282A (en) * 1987-07-02 1989-12-05 Thornfeldt Carl R Treatment of hyperhidrosis, ichthyosis and wrinkling
DE3811081A1 (en) * 1988-03-30 1989-10-12 Schering Ag USE OF TOPIC APPLICABLE PREPARATIONS FOR THE TREATMENT OF AGING SKIN
US4916206A (en) * 1988-11-14 1990-04-10 Olin Corporation Nitramine-containing homopolymers and co-polymers and a process for the preparation thereof
US5008443A (en) * 1988-11-14 1991-04-16 Olin Corporation Process for the preparation of nitramine-containing homopolymers and co-polymers
DE3901279A1 (en) * 1989-01-18 1990-07-19 Hoechst Ag USE OF POLYAMIDOAMINES AS HARDENERS FOR EPOXY RESINS AND CONTAINABLE MIXTURES CONTAINING THEM
DE3903663C1 (en) * 1989-02-08 1990-09-27 Huels Ag, 4370 Marl, De
US5087440A (en) * 1989-07-31 1992-02-11 Salutar, Inc. Heterocyclic derivatives of DTPA used for magnetic resonance imaging
JPH03109498A (en) * 1989-09-25 1991-05-09 Kanebo Ltd Cleaning agent composition having low stimulating property
GB9003201D0 (en) * 1990-02-13 1990-04-11 Unilever Plc Cosmetic composition
DE4206392A1 (en) * 1992-02-29 1993-09-02 Hoechst Ag CURING AGENT FOR EPOXY RESINS
US5505948A (en) * 1993-06-01 1996-04-09 Dermatology Home Products, Inc. Home skin peel composition for producing healthy and attractive skin
JP3376687B2 (en) * 1994-05-24 2003-02-10 味の素株式会社 Detergent composition
US5464929A (en) * 1995-03-06 1995-11-07 Ethicon, Inc. Absorbable polyoxaesters
US5639897A (en) * 1995-12-07 1997-06-17 O'lenick, Jr.; Anthony J. Amido ether amine amphoteric surfactants
JP2000512663A (en) * 1996-02-21 2000-09-26 ジボーダン―ルール（アンテルナシヨナル）ソシエテ アノニム Fragrance precursor
US5834513A (en) * 1996-04-25 1998-11-10 Avon Products, Inc. Oxa diacids and related compounds for treating skin conditions
JP3109498B2 (en) 1998-11-10 2000-11-13 日本電気株式会社 Radio wave detection method and radio wave detection device

Also Published As

Publication number Publication date
US6333356B1 (en) 2001-12-25
JPH1072334A (en) 1998-03-17
HK1020167A1 (en) 2000-03-31
DE69731385T2 (en) 2006-02-02
US6069169A (en) 2000-05-30
US6071962A (en) 2000-06-06
US6534543B2 (en) 2003-03-18
JP2000511900A (en) 2000-09-12
CN1110302C (en) 2003-06-04
AR008384A1 (en) 2000-01-19
CN1221342A (en) 1999-06-30
DE69731385D1 (en) 2004-12-02
CA2256582C (en) 2008-08-12
EP0910362A4 (en) 1999-12-22
EP0910362B1 (en) 2004-10-27
WO1997046231A1 (en) 1997-12-11
ATE280577T1 (en) 2004-11-15
US20020040056A1 (en) 2002-04-04
EP0910362A1 (en) 1999-04-28
BR9709427A (en) 2000-01-11
BR9709427B1 (en) 2009-05-05
US5847003A (en) 1998-12-08

Similar Documents

Publication Publication Date Title
CA2256582A1 (en) Oxa acids and related compounds for treating skin conditions
WO1997046231B1 (en) Oxa acids and related compounds for treating skin conditions
AU4950993A (en) Combination of germicidal agents
CA2064815A1 (en) Therapeutic heterocyclic compounds
ZA988826B (en) Acylsulfamoylbenzamides crop protection compositions comprising them and processes for their preparation
EP0938317A4 (en) Compositions and methods for reducing respiratory depression
BG105395A (en) Benzocyclohexandiones, method for the production and use thereof as herbiicides and plant growth regulators
AR006867A1 (en) TOPIC SKIN COMPOSITION INCLUDING AN OXA-DIÁCIDO COMPOUND, ITS USE TO PREPARE A MEDICATION TO TREAT SKIN CONDITIONS AND NON-THERAPEUTIC COSMETIC METHODS FOR SKIN POLISHING AND TO SOFTEN THE APPLIED HAIR.
ZA988158B (en) Sulfinic acid derivatives and their preparation and use
NZ233735A (en) Heterocyclic substituted aminophenol derivatives
TW368501B (en) 7-(2-aminoethyl)-benzothiazolones
PL341514A1 (en) Substituted compounds of 2-benzylamino-2-phenyl acetamide
ZW9791A1 (en) New heterocyclic chemistry
MX9702203A (en) Substituted pyrazolyl-pyrazole derivatives, processes for their preparation and their use as agents with herbicidal action.
AU7623796A (en) Azahexane derivatives as substrate isosters of retroviral asparate proteases
MY132057A (en) Quinoxalinones, a process for their preparation and their use
ES8507502A1 (en) Substituted anthra(1,9-cd)pyrazol-6(2H)-ones.
GB8829593D0 (en) Novel compounds
HK1028028A1 (en) Substituted heterocyclic compounds, method for preparing and compositions containing same
GR3023757T3 (en) Cyclic benzylamino, benzylamido and benzylimido derivatives as antipsychotic agents.
DE59403966D1 (en) HYDROXYMETHYLFURAZANIC CARBONIC ACID DERIVATIVES AND THEIR USE IN TREATING CARDIOVASCULAR DISEASES
CA2011642A1 (en) Benzoxazine dyes
MX9806249A (en) Dihydrobenzofuran and related compounds useful as anti-inflammatory agents.
ES8604853A1 (en) Acetylene derivatives for the treatment of hypertension and angina.
MY121785A (en) Hydroxamic acid derivatives as inhibitors of the production of soluble cd23

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20170602