CA2257801C - Disposable hemodiafiltration set - Google Patents

Disposable hemodiafiltration set Download PDF

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Publication number
CA2257801C
CA2257801C CA002257801A CA2257801A CA2257801C CA 2257801 C CA2257801 C CA 2257801C CA 002257801 A CA002257801 A CA 002257801A CA 2257801 A CA2257801 A CA 2257801A CA 2257801 C CA2257801 C CA 2257801C
Authority
CA
Canada
Prior art keywords
dialyzer
hemodiafiltration
dialysis
connection
way joint
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002257801A
Other languages
French (fr)
Other versions
CA2257801A1 (en
Inventor
Thore Falkvall
Per-Olov Carlsson
Lars-Olof Sandberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Althin Medical AB
Original Assignee
Althin Medical AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Application filed by Althin Medical AB filed Critical Althin Medical AB
Publication of CA2257801A1 publication Critical patent/CA2257801A1/en
Application granted granted Critical
Publication of CA2257801C publication Critical patent/CA2257801C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/15Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with a cassette forming partially or totally the flow circuit for the treating fluid, e.g. the dialysate fluid circuit or the treating gas circuit
    • A61M1/156Constructional details of the cassette, e.g. specific details on material or shape
    • A61M1/1563Details of incorporated filters
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/24Dialysis ; Membrane extraction
    • B01D61/30Accessories; Auxiliary operation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/168Sterilisation or cleaning before or after use
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/27General characteristics of the apparatus preventing use
    • A61M2205/273General characteristics of the apparatus preventing use preventing reuse, e.g. of disposables
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/75General characteristics of the apparatus with filters

Abstract

A sterile disposable hemodiafiltration set to be connected to a dialysis machine comprising a dialyzer (14) with an extracorporeal blood path (19) and a supplying dialysis liquid supply line (10) which can b e connected to the dialyzer. The hemodiafiltration set comprises a sterilized unit consisting of a hose connection (28) with a sterile filter (27) therein, said hose connection being arranged for connection at one end thereof to the extracorporeal path (19) via a separate pump (29; 30) and being provided with a three-way joint (22) at the other end thereof for connection of said latter end between the dialysis liquid supply line (10) and the dialyzer (14).

Description

WO 981162b9 PCT/SE97/01049 Disposable hemodiafiltration set The invention relates to a sterile disposable hemo-diafiltration set to be connected to a dialysis machine comprising a dialyzer with an extracorporeal blood path and a dialysis liquid supply line, which can be connected to the dialyzer.

In the conventional hemodialysis treatment impurities are separated from the blood in the dialyzer by diffusion while the separation of impurities in hemodiafiltration treatment is effected both by diffusion and by convection dialysis liquid being supplied as a substitute liquid to the blood in the extracorporeal path. Hemodiafiltration treatment is preferred because also greater molecules are separated from the blood; greater molecules cannot be sepa-rated to the same extent when the dialysis treatment includes diffusion only. The dialysis liquid to be supplied to the blood as the substitute liquid is of course subject to higher demands as to sterility than dialysis liquid passing through the dialyzer and, therefore, it undergoes supplementary filtering before being supplied to the blood path.

US-A-4 702 829 describes a machine for hemodiafiltra-tion wherein the dialysis liquid to be used as substitute liquid is passed through two sterile filters provided in the machine which are not used for filtering the dialysis liquid to be supplied to the dialyzer. Having passed the sterile filters the substitute liquid is passed through a disposable line section including a microfilter and being connected to the blood path either on the outlet side of the dialyzer (post-dilution) or on the inlet side of the dialyzer (pre-dilution) .

In the dialysis machine intended for hemodiafiltra-tion according to US-A-4 702 829 as in other dialysis machines on the market, intended for hemodiafiltration there is provided on the machine a separate outlet for substitute liquid to which a disposable set forming part of the hemodiafiltr~~i=ion circuit is connected in order to set up the dialysis machine for hemodiafiltration treatment, said circ=uit being partly permanent and exposed to disinfect=:ion between the treatments in the dialysis machine especial:Ly constructed for hemodiafiltration.
Taking into account 1=hat the dialyzer always is con-nected to the duly:~i.s machine via hoses by quick connectors (Hansen connect=ors>) th.e object of the invention is to pro~ri.de a disposable set which can be easily connected to any d=ialysis machine constructed for hemodialysis and having a:itrafiltration control but in no way constructed or prepared f=or hemodiafiltration treatment, in order to al:Low that the dialysis liquid to be supplied to the c3ialyzc~r is pa.rtiy drained off and after filtration in a ste=rile micro--filter included in the dispc>sable set, is supplied to the blood path.
According to one aspect of the invention, there is provided a sterile ci.ispos<~ble hemodiafiltration set to be connected to a dialT~sis m<~chine comprising a dialyzer with an extracorporeal bl~~oa path and a dialysis liquid supply line which can be ~~onnecte~d to the dialyzer wherein the hemodia:Eilt.ration set comprises a sterilized unit consisting of a hose connection with a sterile filter provided tr.e:rein t;ne hose connection being arranged for connection at one end thereof to the extracorporeal path via a sepa.rat.e pump and being provided with a tr~ree-way jc>int at. the other end thereof for connection of the latter end between the supply line for dialysis liquid and t=he dial~~z,er.

2a In order to achieve raid object the disposable set of the kind referre<~ to above: has obtained according to the invention the charactf~rizing features of claim 1. By this arrangement it is possible tc make dialysis liquid available on any di<~:l.ysis machine constructed for hemodialysis and hawing u:itrafiltration control simply by disconnecting the dialyze:r from th.e dialysis liquid and supply line and interconnecting the three-way joint between the supply :Lane and t:he diaiyzer the dialysis liquid after filtrat::ion in the sterile filter being supplied via the hose connection to the blood path at one side or the other of the c3ia1_yzer (pre-dilution or post-dilution, respectively) According to a preferred embodiment of the invention the sterile filter :is combined with the three-way joint and form; an inteara:l uni~~ therewith.

Tn order to explain the invention in more detail reference is made to the accompanying drawings disclosing an illustrative embodiment and wherein FIG. 1 is a diagram of a dialysis machine constructed for hemodialysis and having ultrafiltration control with the disposable set according to the invention in one embodiment thereof, FIG. 2 is a corresponding diagram of a dialysis machine with a disposable set of a second embodiment, FIG. 3 is a perspective view of a three-way joint forming part of the disposable set, and FIG. 4 is a perspective view of a three-way joint made integral with a sterile filter.
In FIG. 1 a dialysis machine constructed only for hemodialysis and having ultrafiltration control indicated by a block 11. The machine supplies dialysis liquid of high quality in a line l0 which is connected to the dialysis liquid inlet 13 of a dialyzer. The dialysis liquid outlet 15 thereof is connected to an outlet line 16. An extracor-poreal blood path 19 extends through the dialyzer 14 and includes a drip chamber 20.
In order to allow hemodiafiltration treatment by using the dialysis machine with the system described the invention provides a sterile disposable hose set located within the dash line frame 21. This disposable hose set comprises a three-way joint 22 of the kind disclosed in FIG. 3. The three-way joint comprises a socket 23 with quick connectors at both ends thereof, so called Hansen connectors, one connector 24 thereof being a male connector to be connected with supply line 10, and the other connec-tor 25 being a female connector to be connected with inlet 13 for dialysis liquid of the dialyzer 14, The inlet is provided with a male connector and the supply line with a female connector, and in conventional hemodialysis treat-ment these two connectors are interconnected as indicated by a dot-and-dash line, but when a hemodiafiltration treat-ment shall take place the connectors are disconnected and socket 23 of the three-way joint is interconnected therebe-tween. The three-way joint also has a branch socket 26 and is connected at this socket with a sterile filter 27 which is connected to one end of a hose 28. The hose set is delivered in a sterile package. After the three-way joint has been connected as explained above the other end of hose 28 is connected to drip chamber 20 and the hose is placed l0 around the rotor of a peristaltic pump 29.
From the flow of dialysis liquid supplied to the dia-lyzer a flow determined by the peristaltic pump thus is drained off, and after filtration in the microfilter this flow is supplied to the drip chamber to be supplied to the blood in the extracorporeal blood path during a hemodiafil-tration treatment. The supply can take place at another site either for post-dilution, as shown, or for pre-dilu-tion.
In a preferred development of the invention the ster-ile filter 27 is integrated with the three-way joint 22 as shown in FIG. 4. The filter can instead be integrated with another element in the circuit for substitute flow for example with the drip chamber 20.
In the embodiment according to FIG. 2 the peristaltic pump is replaced by a pump - indicated by a symbol 30 -which is combined with the unit formed by the three-way joint 22 and the sterile filter 27. The pump is connected with a turbine which is driven by the dialysis liquid flow to the dialyzer 14, to pump substitute liquid to the extra-corporeal path via the sterile filter.
Summarizing, the invention provides the possibility of effecting by means of an ultrafiltration controlled dialysis machine, constructed for hemodialysis only and not constructed or prepared for hemodiafiltration treatment, a hemodiafiltration treatment without performing any modifi-cation in the machine or the program thereof. In other words, no machine of special construction is necessary for hemodiafiltration.

Claims (5)

6
1. A sterile disposable hemodiafiltration set to be connected to a dialysis machine comprising a dialyzer with an extracorporeal blood path and a dialysis liquid supply line which can be connected to the dialyzer wherein the hemodiafiltration set comprises a sterilized unit consisting of a hose connection with a sterile filter provided therein said hose connection being arranged for connection at one end thereof to the extracorporeal path via a separate pump and being provided with a three-way joint at the other end thereof for connection of said latter end between the supply line for dialysis liquid and the dialyzer.
2. Hemodiafiltration set according to claim 1, wherein the three-way joint is provided with quick connectors for connection to matching quick connectors on the dialysis liquid supply line and the dialyzer, respectively.
3. Hemodiafiltration set according to claim 1 or 2, wherein the three-way joint and the sterile filter are integrated to form a unit.
4. Hemodiafiltration set according to any of claims 1 to 3, wherein the hose connection forms a liquid conducting element in a peristaltic pump.
5. Hemodiafiltration set according to any of claims 1 to 3, wherein the pump is integrated with the three-way joint to form a unit therewith.
CA002257801A 1996-06-13 1997-06-13 Disposable hemodiafiltration set Expired - Fee Related CA2257801C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9602329-6 1996-06-13
SE9602329A SE510127C2 (en) 1996-06-13 1996-06-13 Disposable Hemodia Filtration Kit
PCT/SE1997/001049 WO1998016269A1 (en) 1996-06-13 1997-06-13 Disposable hemodiafiltration set

Publications (2)

Publication Number Publication Date
CA2257801A1 CA2257801A1 (en) 1998-04-23
CA2257801C true CA2257801C (en) 2004-08-24

Family

ID=20402983

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002257801A Expired - Fee Related CA2257801C (en) 1996-06-13 1997-06-13 Disposable hemodiafiltration set

Country Status (12)

Country Link
US (1) US6299769B1 (en)
EP (1) EP0912206B1 (en)
JP (2) JP3974661B2 (en)
KR (1) KR20000016504A (en)
AT (1) ATE249253T1 (en)
AU (1) AU3201497A (en)
CA (1) CA2257801C (en)
DE (1) DE69724785T2 (en)
ES (1) ES2207736T3 (en)
SE (1) SE510127C2 (en)
TR (1) TR199802547T2 (en)
WO (1) WO1998016269A1 (en)

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US6315895B1 (en) 1999-12-30 2001-11-13 Nephros, Inc. Dual-stage hemodiafiltration cartridge
CA2396853A1 (en) 2000-01-11 2001-07-19 Nephros, Inc. Thermally enhanced dialysis/diafiltration system
JP4167058B2 (en) 2000-10-30 2008-10-15 ネフロス・インコーポレーテッド Dual stage filtration cartridge
US7033498B2 (en) * 2000-11-28 2006-04-25 Renal Solutions, Inc. Cartridges useful in cleaning dialysis solutions
US6627164B1 (en) * 2000-11-28 2003-09-30 Renal Solutions, Inc. Sodium zirconium carbonate and zirconium basic carbonate and methods of making the same
US6649063B2 (en) * 2001-07-12 2003-11-18 Nxstage Medical, Inc. Method for performing renal replacement therapy including producing sterile replacement fluid in a renal replacement therapy unit
US6878283B2 (en) * 2001-11-28 2005-04-12 Renal Solutions, Inc. Filter cartridge assemblies and methods for filtering fluids
US6712963B2 (en) * 2002-06-14 2004-03-30 Scilog, Llc Single-use manifold for automated, aseptic transfer of solutions in bioprocessing applications
US9283521B2 (en) 2002-06-14 2016-03-15 Parker-Hannifin Corporation Single-use manifold and sensors for automated, aseptic transfer of solutions in bioprocessing applications
USRE49221E1 (en) 2002-06-14 2022-09-27 Parker Intangibles, Llc Single-use manifolds for automated, aseptic handling of solutions in bioprocessing applications
US20080210606A1 (en) 2004-01-07 2008-09-04 Jeffrey Burbank Filtration System Preparation of Fluids for Medical Applications
US9700663B2 (en) 2005-01-07 2017-07-11 Nxstage Medical, Inc. Filtration system for preparation of fluids for medical applications
DE602004021672D1 (en) 2003-01-07 2009-08-06 Nxstage Medical Inc CHARGE FILTRATION SYSTEM FOR PRODUCING A STERILE SPARELIFE FLUID FOR NURSING TREATMENTS
DE102004053583A1 (en) * 2004-10-01 2006-04-13 Universitätsklinikum Freiburg Peristaltic pump
US8858787B2 (en) * 2007-10-22 2014-10-14 Baxter International Inc. Dialysis system having non-invasive fluid velocity sensing
JP2010207452A (en) * 2009-03-11 2010-09-24 Nipro Corp Dialysate sampling unit
IN2011KN04777A (en) * 2009-04-23 2015-07-10 Fresenius Medical Care De Gmbh
KR101012191B1 (en) * 2010-07-20 2011-02-08 이문섭 Apparatus to produce hemo dialysate and method to produce hemo dialysate
DE102012008551B4 (en) * 2012-04-30 2017-09-07 Fresenius Medical Care Deutschland Gmbh Apparatus for carrying out a method for preserving a blood treatment device and method for preserving a blood treatment device
JP6259108B2 (en) 2014-03-17 2018-01-10 フレセニウス メディカル ケア ホールディングス インコーポレーテッド Cartridge useful for dialysis solution purification
CN108025125B (en) 2015-09-16 2021-05-07 弗雷塞尼斯医疗保健控股公司 Cartridge usable in the purification of dialysis solutions
CN112169050A (en) * 2020-09-28 2021-01-05 中国人民解放军32298部队 Peritoneal dialysis device for nephrology department
CN112618755A (en) * 2021-02-03 2021-04-09 湖南世耀医疗科技有限公司 Disposable blood filter is with degassing unit that disinfects

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Also Published As

Publication number Publication date
CA2257801A1 (en) 1998-04-23
JP2007029748A (en) 2007-02-08
ATE249253T1 (en) 2003-09-15
DE69724785T2 (en) 2004-07-01
EP0912206A1 (en) 1999-05-06
SE510127C2 (en) 1999-04-19
JP3974661B2 (en) 2007-09-12
DE69724785D1 (en) 2003-10-16
AU3201497A (en) 1998-05-11
JP2000512532A (en) 2000-09-26
SE9602329L (en) 1997-12-14
KR20000016504A (en) 2000-03-25
SE9602329D0 (en) 1996-06-13
US6299769B1 (en) 2001-10-09
EP0912206B1 (en) 2003-09-10
WO1998016269A1 (en) 1998-04-23
ES2207736T3 (en) 2004-06-01
TR199802547T2 (en) 1999-03-22

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