CA2257890A1 - Liquisolid systems and methods of preparing same - Google Patents
Liquisolid systems and methods of preparing sameInfo
- Publication number
- CA2257890A1 CA2257890A1 CA002257890A CA2257890A CA2257890A1 CA 2257890 A1 CA2257890 A1 CA 2257890A1 CA 002257890 A CA002257890 A CA 002257890A CA 2257890 A CA2257890 A CA 2257890A CA 2257890 A1 CA2257890 A1 CA 2257890A1
- Authority
- CA
- Canada
- Prior art keywords
- coating materials
- liquid
- carrier
- compressible
- flowing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
Abstract
Liquisolid systems are acceptably flowing and compressible powdered forms of liquid medications. According to the concept of liquisolid systems, liquid liphophilic drugs or water-insoluble drugs dissolved in suitable non-volatile solvents may be converted into free-flowing and readily compressible powders by simple admixture with selected powder excipients referred to as carrier and coating materials; a schematic outline of steps may be drawn for the process.
Various grades of microcrystalline or amorphous cellulose may be used as carriers, whereas very fine particle size silica powders may be used as coating materials. Based on the theory that the carrier and coating materials can retain only certain amounts of liquid and at the same time maintain acceptable flow and compression properties, a new formulation-mathematical model is provided to calculate the optimum quantities of carrier and coating materials required to yield acceptably flowing and compressible liquid/powder admixtures.
Various grades of microcrystalline or amorphous cellulose may be used as carriers, whereas very fine particle size silica powders may be used as coating materials. Based on the theory that the carrier and coating materials can retain only certain amounts of liquid and at the same time maintain acceptable flow and compression properties, a new formulation-mathematical model is provided to calculate the optimum quantities of carrier and coating materials required to yield acceptably flowing and compressible liquid/powder admixtures.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/658,514 | 1996-06-10 | ||
US08/658,514 US5800834A (en) | 1996-06-10 | 1996-06-10 | Liquisolid systems and methods of preparing same |
PCT/US1997/010093 WO1997047290A1 (en) | 1996-06-10 | 1997-06-09 | Liquisolid systems and methods of preparing same |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2257890A1 true CA2257890A1 (en) | 1997-12-18 |
CA2257890C CA2257890C (en) | 2003-10-28 |
Family
ID=24641555
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002257890A Expired - Lifetime CA2257890C (en) | 1996-06-10 | 1997-06-09 | Liquisolid systems and methods of preparing same |
Country Status (13)
Country | Link |
---|---|
US (2) | US5800834A (en) |
EP (1) | EP0946154B1 (en) |
JP (1) | JP2000512295A (en) |
CN (1) | CN1224379C (en) |
AT (1) | ATE486584T1 (en) |
BR (1) | BR9709778A (en) |
CA (1) | CA2257890C (en) |
DE (1) | DE69740040D1 (en) |
ES (1) | ES2355871T3 (en) |
HK (1) | HK1022844A1 (en) |
IL (1) | IL127295A (en) |
RU (1) | RU2209623C2 (en) |
WO (1) | WO1997047290A1 (en) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2159419C (en) * | 1994-10-17 | 2006-07-04 | Pieter De Haan | Solid pharmaceutical composition comprising an excipient capable of binding water |
ATE462417T1 (en) | 1998-08-13 | 2010-04-15 | Cima Labs Inc | MICROEMULSIONS AS SOLID DOSE FORMS FOR ORAL ADMINISTRATION |
CA2355860C (en) * | 1998-12-23 | 2010-03-30 | Alza Corporation | Dosage forms comprising porous particles |
US6342249B1 (en) | 1998-12-23 | 2002-01-29 | Alza Corporation | Controlled release liquid active agent formulation dosage forms |
US6635281B2 (en) | 1998-12-23 | 2003-10-21 | Alza Corporation | Gastric retaining oral liquid dosage form |
US6793934B1 (en) | 1999-12-08 | 2004-09-21 | Shire Laboratories, Inc. | Solid oral dosage form |
US7029700B2 (en) * | 2000-01-14 | 2006-04-18 | Brown University Research Foundation | Micronized freeze-dried particles |
US7833549B2 (en) * | 2000-01-19 | 2010-11-16 | Mannkind Corporation | Dry powder formulations of antihistamine for nasal administration |
US6399101B1 (en) | 2000-03-30 | 2002-06-04 | Mova Pharmaceutical Corp. | Stable thyroid hormone preparations and method of making same |
US7056951B2 (en) | 2000-09-26 | 2006-06-06 | Mutual Pharmaceutical Co., Inc. | Stable solid dosage forms of amino acids and processes for producing same |
US6855333B1 (en) | 2000-10-03 | 2005-02-15 | Mutual Pharmaceutical Co., Inc. | Stabilization of solid thyroid drug formulations |
US6979462B1 (en) | 2000-10-03 | 2005-12-27 | Mutual Pharmaceutical Co., Inc. | Stabilization of solid drug formulations |
JP5684440B2 (en) * | 2001-02-23 | 2015-03-11 | シーマ・ラブス、インコーポレイテッド | Compositions and solid formulations |
US6692771B2 (en) | 2001-02-23 | 2004-02-17 | Cima Labs Inc. | Emulsions as solid dosage forms for oral administration |
ITMI20012366A1 (en) * | 2001-11-09 | 2003-05-09 | Farmatron Ltd | THERAPEUTIC SYSTEMS STABILIZED WITH IMMEDIATE RELEASE AND / OR MODIFIED FOR THE ORAL ADMINISTRATION OF ACTIVE AND / OR EXCIPIENT PRINCIPLES AND / OR WINGS |
US6645526B2 (en) * | 2001-11-13 | 2003-11-11 | Mylan Pharmaceuticals, Inc. | Storage stable thyroxine active drug formulations and methods for their production |
US20030099699A1 (en) * | 2001-11-13 | 2003-05-29 | Hanshew Dwight D. | Storage stable thyroxine active drug formulations and methods for their production |
KR101170844B1 (en) * | 2003-02-24 | 2012-08-02 | 파마슈티칼 프로덕션스, 인크. | Transmucosal drug delivery system |
EP1675571A2 (en) * | 2003-09-30 | 2006-07-05 | Spherics, Inc. | Nanoparticulate therapeutic biologically active agents |
CA2563739C (en) | 2004-03-08 | 2013-07-09 | Spiridon Spireas | Bioavailable solid dosage forms of metaxalone |
MY142989A (en) | 2004-03-10 | 2011-02-14 | Bayer Schering Pharma Ag | Stabilised supersaturated solids of lipophilic drugs |
EP1791520A2 (en) * | 2004-08-19 | 2007-06-06 | Alza Corporation | Controlled release nanoparticle active agent formulation dosage forms and methods |
FR2894822B1 (en) * | 2005-12-20 | 2011-11-18 | Pf Medicament | PHARMACEUTICAL COMPOSITION CONTAINING OMEGA-3 FATTY ACIDS |
US7569612B1 (en) | 2006-08-21 | 2009-08-04 | Mutual Pharmaceutical Company, Inc. | Methods of use of fenofibric acid |
WO2012027222A1 (en) | 2010-08-24 | 2012-03-01 | Rutgers, The State University Of New Jersey | Formulation and manufacture of pharmaceuticals by impregnation onto porous carriers |
CN102949363A (en) * | 2012-11-28 | 2013-03-06 | 山东省中医药研究院 | Ursolic acid liquid-solid compression tablet |
US10660856B2 (en) | 2013-02-01 | 2020-05-26 | W. R. Grace & Co.-Conn. | Porous silica gel as a carrier for liquid technologies |
GB201812022D0 (en) * | 2018-07-24 | 2018-09-05 | Univ Of Sussex | Pharmaceutical methods and compositions |
US10744137B1 (en) * | 2020-01-06 | 2020-08-18 | King Abdulaziz University | Liquisolid tablet containing combined dose of tadalafil and dapoxetine |
CN111067875B (en) * | 2020-01-16 | 2021-11-30 | 兰州大学 | Albendazole liquid-solid compressed tablet and preparation method thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1368112A (en) * | 1971-09-08 | 1974-09-25 | Geistlich Soehne Ag | Chemical compositions for the treatment of hyperlipemia |
DE2400819C2 (en) * | 1974-01-09 | 1982-04-22 | Bayer Ag, 5090 Leverkusen | Process for the production of solid preparations of poorly soluble active pharmaceutical ingredients in extremely fine distribution |
-
1996
- 1996-06-10 US US08/658,514 patent/US5800834A/en not_active Expired - Lifetime
-
1997
- 1997-06-09 EP EP97929921A patent/EP0946154B1/en not_active Expired - Lifetime
- 1997-06-09 ES ES97929921T patent/ES2355871T3/en not_active Expired - Lifetime
- 1997-06-09 JP JP10501792A patent/JP2000512295A/en active Pending
- 1997-06-09 BR BR9709778-0A patent/BR9709778A/en not_active Application Discontinuation
- 1997-06-09 IL IL12729596A patent/IL127295A/en not_active IP Right Cessation
- 1997-06-09 AT AT97929921T patent/ATE486584T1/en not_active IP Right Cessation
- 1997-06-09 CN CNB971953996A patent/CN1224379C/en not_active Expired - Lifetime
- 1997-06-09 CA CA002257890A patent/CA2257890C/en not_active Expired - Lifetime
- 1997-06-09 DE DE69740040T patent/DE69740040D1/en not_active Expired - Lifetime
- 1997-06-09 RU RU99100314/14A patent/RU2209623C2/en not_active IP Right Cessation
- 1997-06-09 WO PCT/US1997/010093 patent/WO1997047290A1/en active IP Right Grant
- 1997-10-01 US US08/937,240 patent/US5968550A/en not_active Expired - Lifetime
-
2000
- 2000-03-31 HK HK00101977.5A patent/HK1022844A1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US5968550A (en) | 1999-10-19 |
EP0946154A4 (en) | 2007-02-07 |
ES2355871T3 (en) | 2011-03-31 |
EP0946154B1 (en) | 2010-11-03 |
EP0946154A1 (en) | 1999-10-06 |
WO1997047290A1 (en) | 1997-12-18 |
CN1221337A (en) | 1999-06-30 |
IL127295A (en) | 2002-05-23 |
US5800834A (en) | 1998-09-01 |
JP2000512295A (en) | 2000-09-19 |
CN1224379C (en) | 2005-10-26 |
RU2209623C2 (en) | 2003-08-10 |
HK1022844A1 (en) | 2000-08-25 |
DE69740040D1 (en) | 2010-12-16 |
AU3387097A (en) | 1998-01-07 |
BR9709778A (en) | 2000-01-11 |
IL127295A0 (en) | 1999-09-22 |
ATE486584T1 (en) | 2010-11-15 |
CA2257890C (en) | 2003-10-28 |
AU709566B2 (en) | 1999-09-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20170609 |