CA2259472A1 - Tubing set, apparatus, and method for separation of fluid components - Google Patents

Tubing set, apparatus, and method for separation of fluid components

Info

Publication number
CA2259472A1
CA2259472A1 CA002259472A CA2259472A CA2259472A1 CA 2259472 A1 CA2259472 A1 CA 2259472A1 CA 002259472 A CA002259472 A CA 002259472A CA 2259472 A CA2259472 A CA 2259472A CA 2259472 A1 CA2259472 A1 CA 2259472A1
Authority
CA
Canada
Prior art keywords
separation
fluid
separation vessel
fluid components
tubing set
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002259472A
Other languages
French (fr)
Other versions
CA2259472C (en
Inventor
Dennis Hlavinka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Terumo BCT Inc
Original Assignee
Cobe Laboratories, Inc.
Dennis Hlavinka
Gambro, Inc.
Gambro Bct, Inc.
Caridianbct, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cobe Laboratories, Inc., Dennis Hlavinka, Gambro, Inc., Gambro Bct, Inc., Caridianbct, Inc. filed Critical Cobe Laboratories, Inc.
Priority to CA002522090A priority Critical patent/CA2522090C/en
Publication of CA2259472A1 publication Critical patent/CA2259472A1/en
Application granted granted Critical
Publication of CA2259472C publication Critical patent/CA2259472C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0209—Multiple bag systems for separating or storing blood components
    • A61M1/0218—Multiple bag systems for separating or storing blood components with filters
    • A61M1/0227—Multiple bag systems for separating or storing blood components with filters and means for securing the filter against damage, e.g. during centrifugation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3618—Magnetic separation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/362—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits changing physical properties of target cells by binding them to added particles to facilitate their subsequent separation from other cells, e.g. immunoaffinity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0407—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles
    • B04B5/0428—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles with flexible receptacles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0209—Multiple bag systems for separating or storing blood components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B04B2005/0471—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation with additional elutriation separation of different particles

Abstract

An apparatus and method are provided for separating components of a fluid or particles. A separation vessel (28) having a barrier dam (62) is provided to initially separate intermediate density component of a fluid, and a fluid chamber (30) is provided to further separate these intermediate density components by forming an elutriative field or saturated fluidized particle bed. The separation vessel is placed in a retainer on a centrifuge rotor (12) and ridges (68) in the retainer form various dams (70) in the separation vessel. Also disclosed are tubing sets and various separation vessels for use with the apparatus.
CA002259472A 1997-05-08 1998-05-07 Tubing set, apparatus, and method for separation of fluid components Expired - Fee Related CA2259472C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002522090A CA2522090C (en) 1997-05-08 1998-05-07 Apparatus, and method for separation of fluid components

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/853,374 US6053856A (en) 1995-04-18 1997-05-08 Tubing set apparatus and method for separation of fluid components
US08/853,374 1997-05-08
PCT/US1998/009407 WO1998050163A1 (en) 1997-05-08 1998-05-07 Tubing set, apparatus, and method for separation of fluid components

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002522090A Division CA2522090C (en) 1997-05-08 1998-05-07 Apparatus, and method for separation of fluid components

Publications (2)

Publication Number Publication Date
CA2259472A1 true CA2259472A1 (en) 1998-11-12
CA2259472C CA2259472C (en) 2006-07-11

Family

ID=25315869

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002522090A Expired - Fee Related CA2522090C (en) 1997-05-08 1998-05-07 Apparatus, and method for separation of fluid components
CA002259472A Expired - Fee Related CA2259472C (en) 1997-05-08 1998-05-07 Tubing set, apparatus, and method for separation of fluid components

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA002522090A Expired - Fee Related CA2522090C (en) 1997-05-08 1998-05-07 Apparatus, and method for separation of fluid components

Country Status (7)

Country Link
US (1) US6053856A (en)
EP (3) EP1714702B1 (en)
JP (2) JP4194667B2 (en)
AU (1) AU7475298A (en)
CA (2) CA2522090C (en)
DE (3) DE69820404T2 (en)
WO (1) WO1998050163A1 (en)

Families Citing this family (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6027441A (en) * 1997-07-01 2000-02-22 Baxter International Inc. Systems and methods providing a liquid-primed, single flow access chamber
US6334842B1 (en) * 1999-03-16 2002-01-01 Gambro, Inc. Centrifugal separation apparatus and method for separating fluid components
US6322488B1 (en) 1999-09-03 2001-11-27 Baxter International Inc. Blood separation chamber with preformed blood flow passages and centralized connection to external tubing
US20020077241A1 (en) * 1999-09-03 2002-06-20 Baxter International Inc. Blood processing systems and methods with quick attachment of a blood separation chamber to a centrifuge rotor
US6860846B2 (en) * 1999-09-03 2005-03-01 Baxter International Inc. Blood processing systems and methods with umbilicus-driven blood processing chambers
US6315707B1 (en) 1999-09-03 2001-11-13 Baxter International Inc. Systems and methods for seperating blood in a rotating field
WO2001017651A1 (en) * 1999-09-03 2001-03-15 Baxter International Inc. Blood separation chamber with preformed blood flow passages and centralized connection to external tubing
US6524231B1 (en) * 1999-09-03 2003-02-25 Baxter International Inc. Blood separation chamber with constricted interior channel and recessed passage
US7651474B2 (en) 1999-10-01 2010-01-26 Caridianbct, Inc. Method and apparatus for leukoreduction of red blood cells
US7169352B1 (en) 1999-12-22 2007-01-30 Gambro, Inc. Extracorporeal blood processing methods and apparatus
US7608053B2 (en) * 2000-01-10 2009-10-27 Caridianbct, Inc. Extracorporeal blood processing methods with return-flow alarm
US6354986B1 (en) 2000-02-16 2002-03-12 Gambro, Inc. Reverse-flow chamber purging during centrifugal separation
EP1186346A1 (en) * 2000-09-05 2002-03-13 Jean-Denis Rochat Rotor chamber for separation of blood or plasma components
WO2002062482A2 (en) * 2000-11-02 2002-08-15 Gambro, Inc. Fluid separation devices, systems and methods
US6890291B2 (en) * 2001-06-25 2005-05-10 Mission Medical, Inc. Integrated automatic blood collection and processing unit
WO2003050536A2 (en) * 2001-12-05 2003-06-19 Gambro, Inc. Methods and apparatus for separation of blood components
EP1455860B1 (en) * 2001-12-10 2011-08-31 CaridianBCT, Inc. Method for the leukoreduction of red blood cells
US20030173274A1 (en) * 2002-02-01 2003-09-18 Frank Corbin Blood component separation device, system, and method including filtration
CA2642653A1 (en) * 2002-04-16 2003-10-30 Gambro Bct, Inc. Blood component processing system, apparatus and method
US6905612B2 (en) * 2003-03-21 2005-06-14 Hanuman Llc Plasma concentrate apparatus and method
US20030205538A1 (en) * 2002-05-03 2003-11-06 Randel Dorian Methods and apparatus for isolating platelets from blood
US7374678B2 (en) * 2002-05-24 2008-05-20 Biomet Biologics, Inc. Apparatus and method for separating and concentrating fluids containing multiple components
US7832566B2 (en) * 2002-05-24 2010-11-16 Biomet Biologics, Llc Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles
US20040182795A1 (en) * 2003-03-21 2004-09-23 Randel Dorian Apparatus and method for concentration of plasma from whole blood
US7992725B2 (en) 2002-05-03 2011-08-09 Biomet Biologics, Llc Buoy suspension fractionation system
US20060278588A1 (en) 2002-05-24 2006-12-14 Woodell-May Jennifer E Apparatus and method for separating and concentrating fluids containing multiple components
AU2003249642A1 (en) 2002-05-24 2003-12-12 Biomet Manufacturing Corp. Apparatus and method for separating and concentrating fluids containing multiple components
US7845499B2 (en) 2002-05-24 2010-12-07 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US11243494B2 (en) 2002-07-31 2022-02-08 Abs Global, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
US7118676B2 (en) * 2003-09-04 2006-10-10 Arryx, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
US7699767B2 (en) 2002-07-31 2010-04-20 Arryx, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
US7297272B2 (en) * 2002-10-24 2007-11-20 Fenwal, Inc. Separation apparatus and method
US6849039B2 (en) 2002-10-24 2005-02-01 Baxter International Inc. Blood processing systems and methods for collecting plasma free or essentially free of cellular blood components
JP4866551B2 (en) * 2003-05-15 2012-02-01 ヒューレット−パッカード デベロップメント カンパニー エル．ピー． Printing system
EP2206559B1 (en) * 2003-07-02 2016-11-30 Terumo BCT, Inc. Optical cell for a separation chamber of a density centrifuge blood processing system
US7327443B2 (en) * 2004-07-01 2008-02-05 Gambro Bct, Inc Stroboscopic LED light source for blood processing apparatus
US7704454B1 (en) * 2003-10-08 2010-04-27 Caridianbct, Inc. Methods and devices for processing blood
US7671975B2 (en) * 2004-07-01 2010-03-02 Caridianbct, Inc. Blood processing apparatus with dedicated stroboscopic controller for LED source
EP1848473B1 (en) * 2005-02-07 2013-05-22 Hanuman LLC Plasma concentrator device
US7708152B2 (en) * 2005-02-07 2010-05-04 Hanuman Llc Method and apparatus for preparing platelet rich plasma and concentrates thereof
EP2666494B1 (en) * 2005-02-07 2018-01-17 Hanuman LLC Platelet rich plasma concentrate apparatus and method
US7866485B2 (en) 2005-02-07 2011-01-11 Hanuman, Llc Apparatus and method for preparing platelet rich plasma and concentrates thereof
US7473216B2 (en) 2005-04-21 2009-01-06 Fresenius Hemocare Deutschland Gmbh Apparatus for separation of a fluid with a separation channel having a mixer component
US7694828B2 (en) 2005-04-27 2010-04-13 Biomet Manufacturing Corp. Method and apparatus for producing autologous clotting components
US8048297B2 (en) 2005-08-23 2011-11-01 Biomet Biologics, Llc Method and apparatus for collecting biological materials
US7771590B2 (en) * 2005-08-23 2010-08-10 Biomet Manufacturing Corp. Method and apparatus for collecting biological materials
EP1933899A1 (en) * 2005-10-05 2008-06-25 Gambro BCT, Inc. Method and apparatus for leukoreduction of red blood cells
US7386815B2 (en) * 2005-10-27 2008-06-10 International Business Machines Corporation Test yield estimate for semiconductor products created from a library
US20070102374A1 (en) * 2005-11-04 2007-05-10 Gambro, Inc. Blood processing apparatus with controlled cell capture chamber and method background of the invention
US8567609B2 (en) 2006-05-25 2013-10-29 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
WO2008021623A1 (en) * 2006-08-10 2008-02-21 Gambro Bct, Inc. Method and apparatus for recirculating elutriation fluids
US20080041772A1 (en) * 2006-08-17 2008-02-21 Gambro Bct, Inc. Blood Processing Apparatus with Robust Outflow Process Control
CA2677258A1 (en) 2006-08-17 2008-02-21 Caridianbct, Inc. Blood processing apparatus with robust outflow process control
CN101501472A (en) 2006-08-17 2009-08-05 科安比司特公司 Blood processing apparatus with robust automated process control
US8328024B2 (en) 2007-04-12 2012-12-11 Hanuman, Llc Buoy suspension fractionation system
EP2146794B1 (en) 2007-04-12 2016-10-19 Biomet Biologics, LLC Buoy suspension fractionation system
US7857744B2 (en) * 2007-06-19 2010-12-28 Caridianbct, Inc. Blood processing apparatus with flared cell capture chamber and method
ATE525636T1 (en) * 2007-12-18 2011-10-15 Caridianbct Inc BLOOD TREATMENT DEVICE HAVING A SEALED DIFFUSER IN AN OPTICAL CONTROL DEVICE
US8066888B2 (en) * 2007-12-27 2011-11-29 Caridianbct, Inc. Blood processing apparatus with controlled cell capture chamber trigger
US8685258B2 (en) * 2008-02-27 2014-04-01 Fenwal, Inc. Systems and methods for conveying multiple blood components to a recipient
EP2567692B1 (en) 2008-02-27 2016-04-06 Biomet Biologics, LLC Use of a device for obtaining interleukin-1 receptor antagonist rich solutions
US8075468B2 (en) * 2008-02-27 2011-12-13 Fenwal, Inc. Systems and methods for mid-processing calculation of blood composition
EP2254991B1 (en) 2008-02-29 2018-08-22 Biomet Manufacturing, LLC A system and process for separating a material
US8012077B2 (en) * 2008-05-23 2011-09-06 Biomet Biologics, Llc Blood separating device
US7963901B2 (en) * 2008-09-12 2011-06-21 Caridianbct, Inc. Blood processing apparatus with cell capture chamber with protruding inlet
US7951059B2 (en) * 2008-09-18 2011-05-31 Caridianbct, Inc. Blood processing apparatus with optical reference control
US7828709B2 (en) * 2008-09-30 2010-11-09 Caridianbct, Inc. Blood processing apparatus with incipient spill-over detection
WO2010074929A2 (en) * 2008-12-22 2010-07-01 Caridianbct, Inc. Blood processing apparatus with digitally controlled linear voltage regulator for optical pulses
US8187475B2 (en) 2009-03-06 2012-05-29 Biomet Biologics, Llc Method and apparatus for producing autologous thrombin
US8313954B2 (en) 2009-04-03 2012-11-20 Biomet Biologics, Llc All-in-one means of separating blood components
US9011800B2 (en) 2009-07-16 2015-04-21 Biomet Biologics, Llc Method and apparatus for separating biological materials
EP2309266A1 (en) 2009-09-21 2011-04-13 F. Hoffmann-La Roche AG Method for carrying out reactions in an analytical device
EP2644216B1 (en) 2009-12-11 2016-04-06 Terumo BCT, Inc. System for blood separation with shielded extraction port and optical control
US8591391B2 (en) 2010-04-12 2013-11-26 Biomet Biologics, Llc Method and apparatus for separating a material
JP5833648B2 (en) 2010-07-09 2015-12-16 テルモ ビーシーティー、インコーポレーテッド Blood processing method that automatically adjusts the collection target value
US10908066B2 (en) 2010-11-16 2021-02-02 1087 Systems, Inc. Use of vibrational spectroscopy for microfluidic liquid measurement
EP2590697B1 (en) 2011-06-13 2015-03-04 Terumo BCT, Inc. System for blood separation with side-tapped separation chamber
EP2717942B1 (en) 2011-06-13 2016-05-18 Terumo BCT, Inc. System for blood separation with gravity valve for controlling a side-tapped separation chamber
EP2741797B1 (en) 2011-08-12 2016-06-08 Terumo BCT, Inc. System for blood separation with replacement fluid apparatus and method
US9327296B2 (en) 2012-01-27 2016-05-03 Fenwal, Inc. Fluid separation chambers for fluid processing systems
US9033858B2 (en) 2012-02-02 2015-05-19 Fenwal, Inc. Method and apparatus for concentrating platelets from platelet-rich plasma
DE102012104759B4 (en) 2012-06-01 2022-01-05 Medicap Homecare Gmbh Device for the separation of blood cells and blood plasma
US9642956B2 (en) 2012-08-27 2017-05-09 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
CN102944535B (en) * 2012-11-30 2015-01-07 金卫医疗科技(上海)有限公司 Monitoring method for layering condition of whole blood in centrifugal cup and photoelectric sensing device
EP2956187B1 (en) 2013-02-18 2017-11-01 Terumo BCT, Inc. System for blood separation with a separation chamber having an internal gravity valve
US10143725B2 (en) 2013-03-15 2018-12-04 Biomet Biologics, Llc Treatment of pain using protein solutions
US20140271589A1 (en) 2013-03-15 2014-09-18 Biomet Biologics, Llc Treatment of collagen defects using protein solutions
US10208095B2 (en) 2013-03-15 2019-02-19 Biomet Manufacturing, Llc Methods for making cytokine compositions from tissues using non-centrifugal methods
US9950035B2 (en) 2013-03-15 2018-04-24 Biomet Biologics, Llc Methods and non-immunogenic compositions for treating inflammatory disorders
US9895418B2 (en) 2013-03-15 2018-02-20 Biomet Biologics, Llc Treatment of peripheral vascular disease using protein solutions
US8961904B2 (en) 2013-07-16 2015-02-24 Premium Genetics (Uk) Ltd. Microfluidic chip
US11796449B2 (en) 2013-10-30 2023-10-24 Abs Global, Inc. Microfluidic system and method with focused energy apparatus
US10618060B2 (en) 2013-12-20 2020-04-14 Terumo Bct, Inc. Centrifuge safety mechanism
US9796166B2 (en) 2014-03-24 2017-10-24 Fenwal, Inc. Flexible biological fluid filters
US9968738B2 (en) 2014-03-24 2018-05-15 Fenwal, Inc. Biological fluid filters with molded frame and methods for making such filters
US9782707B2 (en) 2014-03-24 2017-10-10 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
US10159778B2 (en) 2014-03-24 2018-12-25 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
US10376627B2 (en) 2014-03-24 2019-08-13 Fenwal, Inc. Flexible biological fluid filters
EP3122465B1 (en) 2014-03-28 2018-06-20 Terumo BCT, Inc. Gain in separation processes with control loop
US9550028B2 (en) 2014-05-06 2017-01-24 Biomet Biologics, LLC. Single step desiccating bead-in-syringe concentrating device
RU2708206C2 (en) 2014-08-14 2019-12-04 ТЕРУМО БиСиТи, ИНК. Particle treatment
EP3259579B1 (en) 2015-02-19 2022-09-14 1087 Systems, Inc. Scanning infrared measurement system
US9713810B2 (en) 2015-03-30 2017-07-25 Biomet Biologics, Llc Cell washing plunger using centrifugal force
US9757721B2 (en) 2015-05-11 2017-09-12 Biomet Biologics, Llc Cell washing plunger using centrifugal force
EP3124063B1 (en) 2015-07-29 2019-04-10 Fenwal, Inc. Five-port blood separation chamber and methods of using the same
US10585085B2 (en) 2016-10-13 2020-03-10 Terumo Bct, Inc. Collecting components of a fluid
WO2019226790A1 (en) 2018-05-23 2019-11-28 Abs Global, Inc. Systems and methods for particle focusing in microchannels
EP4245140A3 (en) 2019-04-18 2024-01-17 ABS Global, Inc. System and process for continuous addition of cryoprotectant
US11628439B2 (en) 2020-01-13 2023-04-18 Abs Global, Inc. Single-sheath microfluidic chip

Family Cites Families (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1684870A (en) * 1927-10-17 1928-09-18 Frank D Lewis Centrifugal concentrating and amalgamating apparatus of the vertical type
US2616619A (en) * 1948-08-30 1952-11-04 Norman A Macleod Method and apparatus for centrifugal elutriation
US2878995A (en) * 1953-08-24 1959-03-24 Gen Motors Corp Centrifuge for liquids
US3771715A (en) * 1970-11-24 1973-11-13 Escher Wyss Ag Self-cleaning centrifugal separator
FR2180589B1 (en) * 1972-04-21 1975-03-21 Loison Robert
US4934995A (en) * 1977-08-12 1990-06-19 Baxter International Inc. Blood component centrifuge having collapsible inner liner
US3825175A (en) * 1973-06-06 1974-07-23 Atomic Energy Commission Centrifugal particle elutriator and method of use
US4010894A (en) * 1975-11-21 1977-03-08 International Business Machines Corporation Centrifuge fluid container
US4425112A (en) * 1976-02-25 1984-01-10 The United States Of America As Represented By The Department Of Health And Human Services Flow-through centrifuge
DE2658926A1 (en) * 1976-12-24 1978-06-29 Heraeus Christ Gmbh Centrifuge rotor for washing blood cells - has two formed components between which films are mounted
US4091989A (en) * 1977-01-04 1978-05-30 Schlutz Charles A Continuous flow fractionation and separation device and method
US4094461A (en) * 1977-06-27 1978-06-13 International Business Machines Corporation Centrifuge collecting chamber
US4419089A (en) * 1977-07-19 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Blood cell separator
US4356958A (en) * 1977-07-19 1982-11-02 The United States Of America As Represented By The Secretary Of Health And Human Services Blood cell separator
US5217427A (en) * 1977-08-12 1993-06-08 Baxter International Inc. Centrifuge assembly
US5006103A (en) * 1977-08-12 1991-04-09 Baxter International Inc. Disposable container for a centrifuge
US5571068A (en) * 1977-08-12 1996-11-05 Baxter International Inc. Centrifuge assembly
US4387848A (en) * 1977-10-03 1983-06-14 International Business Machines Corporation Centrifuge assembly
US4146172A (en) * 1977-10-18 1979-03-27 Baxter Travenol Laboratories, Inc. Centrifugal liquid processing system
US4386730A (en) * 1978-07-21 1983-06-07 International Business Machines Corporation Centrifuge assembly
US4187979A (en) * 1978-09-21 1980-02-12 Baxter Travenol Laboratories, Inc. Method and system for fractionating a quantity of blood into the components thereof
US4413772A (en) * 1979-09-10 1983-11-08 E. I. Du Pont De Nemours And Company Apparatus for centrifugal separation
US4413771A (en) * 1979-09-10 1983-11-08 E. I. Du Pont De Nemours And Company Method and apparatus for centrifugal separation
US4268393A (en) * 1980-05-05 1981-05-19 The Institutes Of Medical Sciences Apparatus for centrifugal separation of platelet-rich plasma
US4269718A (en) * 1980-05-05 1981-05-26 The Institutes Of Medical Sciences Process and device for centrifugal separation of platelets
US4350283A (en) * 1980-07-01 1982-09-21 Beckman Instruments, Inc. Centrifugal elutriator rotor
US4316576A (en) * 1980-11-06 1982-02-23 Baxter Travenol Laboratories, Inc. Method and chamber for separating granulocytes from whole blood
US4322298A (en) * 1981-06-01 1982-03-30 Advanced Blood Component Technology, Inc. Centrifugal cell separator, and method of use thereof
US4421503A (en) * 1981-07-09 1983-12-20 Haemonetics Corporation Fluid processing centrifuge and apparatus thereof
US4416654A (en) * 1981-09-03 1983-11-22 Haemonetics Corporation Pheresis apparatus
US4464167A (en) * 1981-09-03 1984-08-07 Haemonetics Corporation Pheresis apparatus
US4447221A (en) * 1982-06-15 1984-05-08 International Business Machines Corporation Continuous flow centrifuge assembly
US4680025A (en) * 1982-08-24 1987-07-14 Baxter Travenol Laboratories, Inc. Blood component collection systems and methods
US4610846A (en) * 1983-08-18 1986-09-09 Hans Martin Compartmentalized centrifugation chamber
DE3578502D1 (en) * 1984-03-15 1990-08-09 Asahi Medical Co FILTER UNIT FOR SEPARATING LEUKOCYTES.
DE3410286C2 (en) * 1984-03-21 1986-01-23 Fresenius AG, 6380 Bad Homburg Method for separating blood and device for carrying out the method
US4647279A (en) * 1985-10-18 1987-03-03 Cobe Laboratories, Inc. Centrifugal separator
US4846974A (en) * 1985-11-14 1989-07-11 Norfolk Scientific, Inc. Centrifuge system and fluid container therefor
US4708710A (en) * 1986-03-27 1987-11-24 E. I. Du Pont De Nemours And Company Particle separation process
JPH0651060B1 (en) * 1986-03-28 1994-07-06 Asahi Medical Co
US4708712A (en) * 1986-03-28 1987-11-24 Cobe Laboratories, Inc. Continuous-loop centrifugal separator
US4933291A (en) * 1986-12-22 1990-06-12 Eastman Kodak Company Centrifugable pipette tip and pipette therefor
DE3700122A1 (en) * 1987-01-03 1988-07-14 Manfred Lutz Chamber for separating a particle mixture according to the countercurrent centrifugation method
US5213970A (en) * 1987-01-23 1993-05-25 Board Of Regents, The University Of Texas System Method for obtaining soluble antitumor factor
US5370802A (en) * 1987-01-30 1994-12-06 Baxter International Inc. Enhanced yield platelet collection systems and methods
US4834890A (en) * 1987-01-30 1989-05-30 Baxter International Inc. Centrifugation pheresis system
US5641414A (en) * 1987-01-30 1997-06-24 Baxter International Inc. Blood processing systems and methods which restrict in flow of whole blood to increase platelet yields
US5632893A (en) * 1987-01-30 1997-05-27 Baxter Internatinoal Inc. Enhanced yield blood processing systems with angled interface control surface
DE3711177A1 (en) * 1987-04-02 1988-10-13 Dornier System Gmbh METHOD AND DEVICE FOR OPERATING FLUIDIZED LAYER REACTORS
US4808151A (en) * 1987-04-27 1989-02-28 E. I. Du Pont De Nemours And Company Simplified method for the preparation of human lymphokine activated killer cells
US4939087A (en) * 1987-05-12 1990-07-03 Washington State University Research Foundation, Inc. Method for continuous centrifugal bioprocessing
US4939081A (en) * 1987-05-27 1990-07-03 The Netherlands Cancer Institute Cell-separation
US4798579A (en) * 1987-10-30 1989-01-17 Beckman Instruments, Inc. Rotor for centrifuge
US4851126A (en) * 1987-11-25 1989-07-25 Baxter International Inc. Apparatus and methods for generating platelet concentrate
CA1334189C (en) * 1988-10-07 1995-01-31 T. Michael Dennehey Centrifugal fluid processing system and method
US5078671A (en) * 1988-10-07 1992-01-07 Baxter International Inc. Centrifugal fluid processing system and method
US4936820A (en) * 1988-10-07 1990-06-26 Baxter International Inc. High volume centrifugal fluid processing system and method for cultured cell suspensions and the like
US5229012A (en) * 1989-05-09 1993-07-20 Pall Corporation Method for depletion of the leucocyte content of blood and blood components
US5344561A (en) * 1989-05-09 1994-09-06 Pall Corporation Device for depletion of the leucocyte content of blood and blood components
US5316667A (en) * 1989-05-26 1994-05-31 Baxter International Inc. Time based interface detection systems for blood processing apparatus
EP0406485A1 (en) * 1989-07-03 1991-01-09 NPBI Nederlands Produktielaboratorium voor Bloedtransfusieapparatuur en Infusievloeistoffen B.V. A method for the removal of leukocytes from a leukocyte-containing suspension and filter unit for use with the method
DE69020248T2 (en) * 1989-07-14 1996-01-25 Terumo Corp Filter material for the separation of leukocytes and method for its production.
US5152905A (en) * 1989-09-12 1992-10-06 Pall Corporation Method for processing blood for human transfusion
US5100564A (en) * 1990-11-06 1992-03-31 Pall Corporation Blood collection and processing system
JP2523938B2 (en) * 1989-09-18 1996-08-14 テルモ株式会社 Platelet purification filter
US5089146A (en) * 1990-02-12 1992-02-18 Miles Inc. Pre-storage filtration of platelets
US5224921A (en) * 1990-05-31 1993-07-06 Baxter International Inc. Small volume collection chamber
US5217627A (en) * 1990-11-06 1993-06-08 Pall Corporation System and method for processing biological fluid
FR2671985B1 (en) * 1991-01-30 1993-04-09 Snecma CENTRIFUGAL OIL FILTER WITH PARTICLE COLLECTION.
US5282982A (en) * 1991-07-12 1994-02-01 Wells John R Blood washing method
DE4126341C1 (en) * 1991-08-09 1993-01-28 Fresenius Ag, 6380 Bad Homburg, De
DE69223042T2 (en) * 1991-12-23 1998-06-10 Baxter Int CENTRIFUGE WOBEI BASKET AND COIL IS SEPARABLE TO PROVIDE ACCESS TO THE SEPARATION CHAMBER
CA2103914A1 (en) * 1991-12-23 1993-06-24 Warren P. Williamson, Iv Centrifugal processing system with direct access drawer
US5437624A (en) * 1993-08-23 1995-08-01 Cobe Laboratories, Inc. Single needle recirculation system for harvesting blood components
US5672346A (en) * 1992-07-27 1997-09-30 Indiana University Foundation Human stem cell compositions and methods
DE4226974C2 (en) * 1992-08-14 1994-08-11 Fresenius Ag Method and device for the continuous preparation of a cell suspension
US5397479A (en) * 1993-04-26 1995-03-14 International Remote Imaging Systems, Inc. Composition and method for enrichment of white blood cells from whole human blood
DE69332926T2 (en) * 1993-05-28 2004-03-11 Baxter International Inc., Deerfield CONTINUOUS CENTRIFUGATION METHOD FOR SEPARATING BIOLOGICAL COMPONENTS FROM HETEROGENIC CELL POPULATIONS
EP0627228A1 (en) * 1993-06-01 1994-12-07 ASAHI MEDICAL Co., Ltd. Centrifuge for separating blood material into components thereof
US5409813A (en) * 1993-09-30 1995-04-25 Systemix, Inc. Method for mammalian cell separation from a mixture of cell populations
US5729038A (en) * 1995-12-15 1998-03-17 Harris Corporation Silicon-glass bonded wafers
WO1996033023A1 (en) * 1995-04-18 1996-10-24 Cobe Laboratories, Inc. Particle separation apparatus and method
US5674173A (en) * 1995-04-18 1997-10-07 Cobe Laboratories, Inc. Apparatus for separating particles
US5865785A (en) * 1996-02-23 1999-02-02 Baxter International Inc. Systems and methods for on line finishing of cellular blood products like platelets harvested for therapeutic purposes

Also Published As

Publication number Publication date
EP1375006A1 (en) 2004-01-02
DE69820404D1 (en) 2004-01-22
DE69836648T2 (en) 2007-09-27
JP4194667B2 (en) 2008-12-10
WO1998050163A1 (en) 1998-11-12
CA2259472C (en) 2006-07-11
DE69840459D1 (en) 2009-02-26
CA2522090C (en) 2006-12-12
CA2522090A1 (en) 1998-11-12
EP1714702B1 (en) 2009-01-07
JP2008289925A (en) 2008-12-04
JP2000515412A (en) 2000-11-21
EP1375006B1 (en) 2006-12-13
AU7475298A (en) 1998-11-27
EP0923415A1 (en) 1999-06-23
DE69836648D1 (en) 2007-01-25
DE69820404T2 (en) 2004-10-07
EP1714702A1 (en) 2006-10-25
US6053856A (en) 2000-04-25
EP0923415B1 (en) 2003-12-10
JP4536806B2 (en) 2010-09-01

Similar Documents

Publication Publication Date Title
CA2259472A1 (en) Tubing set, apparatus, and method for separation of fluid components
MY115390A (en) Process and apparatus for the stripping of fluidized solids and use in a fluid cracking process
EP1854545A3 (en) Centrifugal separation apparatus and method for separating fluid components
BG100550A (en) Centrifugal separator and method
CA2095623A1 (en) System and method for processing biological fluids
EP0499693A3 (en) Method of differentiating erythroblasts from other cells by flow cytometry
EP1512362A3 (en) Apparatus and method for separating particles from a cyclonic fluid flow
WO1999012590A8 (en) Method and apparatus for collecting hyperconcentrated platelets
AU638807B2 (en) Device for generating fluid flow and method of manufacture thereof
CA2327522A1 (en) Incorporation of active substances in carrier matrixes
AU3115289A (en) Apparatus for the separation of solids from a mixture of solids and fluid
GB2223958B (en) Separator
EP0606930A3 (en) Process for preparation of polymer particles, process for preparation of toner particles and particles prepared according to these processes.
MY114766A (en) Separation apparatus
WO1992009743A3 (en) A screening system
AUPR675501A0 (en) A method and device for separating particulate material
AU4248189A (en) High solids vinyl acetate-ethylene emulsion polymers and the method of preparation
AU4895396A (en) Dense fluid centrifugal separation process and apparatus
JPS5310173A (en) Apparatus for separating solid from suspension
JPS52136985A (en) Fermentation and dialysis
EP0230928A3 (en) A method of regenerating a dynamic membrane in a separation means for a liquid medium and device for carrying out the method
EP0213508A3 (en) Method and apparatus for use in separating solids from liquids
JPS521567A (en) Settling separation method by making use of ultrasonic wave
PH23976A (en) Noise suppression and particle separation apparatus for high pressure gaseous fluid flows
AU5328790A (en) An apparatus for separating solid particles from a liquid medium

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed