CA2259707A1 - Disinfecting and sterilizing concentrate containing an aromatic dialdehyde and a neutral ph buffering system - Google Patents

Disinfecting and sterilizing concentrate containing an aromatic dialdehyde and a neutral ph buffering system Download PDF

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Publication number
CA2259707A1
CA2259707A1 CA002259707A CA2259707A CA2259707A1 CA 2259707 A1 CA2259707 A1 CA 2259707A1 CA 002259707 A CA002259707 A CA 002259707A CA 2259707 A CA2259707 A CA 2259707A CA 2259707 A1 CA2259707 A1 CA 2259707A1
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CA
Canada
Prior art keywords
disinfecting
present
sterilizing concentrate
concentration ranging
concentration
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002259707A
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French (fr)
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CA2259707C (en
Inventor
Philip A. Block
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Ethicon Inc
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Ethicon Inc
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Application filed by Ethicon Inc filed Critical Ethicon Inc
Publication of CA2259707A1 publication Critical patent/CA2259707A1/en
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Publication of CA2259707C publication Critical patent/CA2259707C/en
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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
    • A01N35/04—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aldehyde or keto groups, or thio analogues thereof, directly attached to an aromatic ring system, e.g. acetophenone; Derivatives thereof, e.g. acetals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

A disinfecting and sterilizing concentrate containing an aromatic dialdehyde and a neutral pH buffering system is provided. Aromatic dialdehyde concentrations of greater than 5 w/w% are achieved while maintaining the stability of the buffering system. A method and a kit for preparing a disinfecting and sterilizing concentrate is also provided.

Claims (24)

1. A disinfecting and sterilizing concentrate comprising:
(a) an aromatic dialdehyde present in a concentration greater than 5 w/w%, (b) a water miscible solvent, and (c) a buffering salt.
2. The disinfecting and sterilizing concentrate of Claim 1, wherein (a) the aromatic dialdehyde is selected from the group consisting of ortho-phthalaldehyde, isophthalaldehyde, and terephthalaldehyde.
3. The disinfecting and sterilizing concentrate of Claim 1, wherein (b) the solvent is selected from the group consisting of ethanol, methanol, 1,4-butanediol, ethylene glycol, propylene glycol, tetrahydrofuran, isopropanol, polyols, dimethylsulfoxide, and dioxane.
4. The disinfecting and sterilizing concentrate of Claim 1, wherein (c) the buffering salt is selected from the group consisting of boric acid/sodium borate, maleic acid/sodium maleate, monobasic phosphate/dibasic phosphate, and citric acid/sodium citrate.
5. The disinfecting and sterilizing concentrate of Claim 1, further comprising (d) a stabilizer.
6. The disinfecting and sterilizing concentrate of Claim 5, wherein (d) the stabilizer is selected from the group consisting of glycerol, sorbitol, and propylene carbonate.
7. The disinfecting and sterilizing concentrate of Claim 1, further comprising (e) at least one minor ingredient selected from the group consisting of dyes, chelants, and builders.
8. The disinfecting and sterilizing concentrate of Claim 5, further comprising (e) at least one minor ingredient selected from the group consisting of dyes, chelants, and builders.
9. The disinfecting and sterilizing concentrate of Claim 1, wherein (a) the aromatic dialdehyde is present in a concentration greater than 5 w/w% up to about 30 w/w%, (b) the solvent present in a concentration ranging from about 1 w/w% to about 60 w/w%, and (c) the buffering salt is present in a concentration ranging from about 0.5 w/w% to about 25 w/w%.
10. The disinfecting and sterilizing concentrate of Claim 9, further comprising (d) a stabilizer present in a concentration up to about 50 w/w%.
11. The disinfecting and sterilizing concentrate of Claim 1, wherein (a) the aromatic dialdehyde is present in a concentration greater than 5 w/w% up to about 25 w/w%, (b) the solvent is present in a concentration ranging from about 5 w/w% to about 50 w/w%, and (c) the buffering salt is present in a concentration ranging from about 1 w/w % to about 20 w/w%.
12. The disinfecting and sterilizing concentrate of Claim 11, further comprising (d) a stabilizer present in a concentration up to about 45 w/w%.
13. The disinfecting and sterilizing concentrate of Claim 1 wherein (a) the aromatic dialdehyde is present in a concentration ranging from about 10 w/w%
to about 20 w/w%, (b) the solvent is present in a concentration ranging from about 10 w/w% to about 45 w/w%, and (c) the buffering salt is present in a concentration ranging from about 1 w/w % to about 15 w/w%.
14. The disinfecting and sterilizing concentrate of Claim 13, further comprising (d) a stabilizer present in a concentration up to 40 w/w%.
15. A method for making a disinfecting and sterilizing concentrate comprising:
(i) mixing an amount of an aromatic dialdehyde greater than 5 w/w% with a water-miscible solvent and (ii) admixing a buffering salt.
16. The method of Claim 14, further comprising (iii) admixing a stabilizer.
17. The method of Claim 14, further comprising (iv) admixing at least one minor ingredient selected from the group consisting of dyes, chelants, and builders.
18. A disinfecting and sterilizing concentrate prepared in accordance with the method of Claim 15.
19. A disinfecting and sterilizing concentrate prepared in accordance with the method of Claim 16.
20. A disinfecting and sterilizing concentrate prepared in accordance with the method of Claim 17.
21. A kit for preparing a disinfecting and sterilizing concentrate comprising (a) a first solution having (i) an aromatic dialdehyde present in a concentration greater than 5 w/w% and (ii) a water-miscible solvent, and (b) a second solution having (iii) at least a buffering salt.
22. The kit of Claim 21, wherein (i) the aromatic dialdehyde of the first solution is present in a concentration greater than 5 w/w% up to about 60 w/w%, (ii) the solvent of the first solution is present in a concentration ranging from about 2 w/w% to about 70 w/w%, and (iii) the buffering salt of the second solution is present in a concentration ranging from about 1 w/w% to about 50 w/w%.
23. The kit of Claim 21, wherein (i) the aromatic dialdehyde of the first solution is present in a concentration ranging from about 10 w/w% to about 50 w/w%, (ii) the solvent of the first solution is present in a concentration ranging from about 10 w/w% to about 50 w/w%, and (iii) the buffering salt of the second solution is present in a concentration ranging from about 2 w/w% to about 40 w/w%.
24. The kit of Claim 21, wherein (i) the aromatic dialdehyde of the first solution is present in a concentration ranging from about 20 w/w% to about 40 w/w%, (ii) the solvent of the first solution is present in a concentration ranging from about 20 w/w% to about 50 w/w%, and (iii) the buffering salt of the second solution is present in a concentration ranging from about 2 w/w% to about 30 w/w%.
CA2259707A 1998-01-21 1999-01-20 Disinfecting and sterilizing concentrate containing an aromatic dialdehyde and a neutral ph buffering system Expired - Lifetime CA2259707C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/010,351 1998-01-21
US09/010,351 US5936001A (en) 1998-01-21 1998-01-21 Disinfecting and sterilizing concentrate containing an aromatic dialdehyde and a neutral pH buffering system

Publications (2)

Publication Number Publication Date
CA2259707A1 true CA2259707A1 (en) 1999-07-21
CA2259707C CA2259707C (en) 2010-08-17

Family

ID=21745339

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2259707A Expired - Lifetime CA2259707C (en) 1998-01-21 1999-01-20 Disinfecting and sterilizing concentrate containing an aromatic dialdehyde and a neutral ph buffering system

Country Status (7)

Country Link
US (2) US5936001A (en)
EP (1) EP0937395B2 (en)
JP (1) JP2000001406A (en)
AU (1) AU747387B2 (en)
CA (1) CA2259707C (en)
DE (1) DE69908206T3 (en)
ES (1) ES2200467T5 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040071592A1 (en) * 2002-10-10 2004-04-15 Ioana Annis Fast dissolving solid ortho-phthalic aldehyde formulations
US20050136086A1 (en) * 2003-12-19 2005-06-23 Rafael Herruzo Efficacy enhancers for germicides
US20050136118A1 (en) * 2003-12-19 2005-06-23 Wu Su-Syin S. Distribution and preparation of germicidal compositions
US20050238732A1 (en) * 2003-12-19 2005-10-27 Kaitao Lu Carbonated germicide with pressure control
US7390837B2 (en) * 2004-01-30 2008-06-24 Ethicon, Inc. Germicidal compositions containing phenylmalonaldehyde-type compounds, or mixtures of phenylmalonaldehyde-type compounds and phthalaldehydes, and methods of using such compositions for disinfection or sterilization
US20050171215A1 (en) * 2004-01-30 2005-08-04 Ethicon, Inc. Germicidal compositions containing halogenated phthalaldehyes, and methods of using such compositions for disinfection or sterilization
US6891069B1 (en) 2004-01-30 2005-05-10 Ethicon, Inc. Synthesis of 4-substituted phthalaldehyde
US7476767B2 (en) 2004-01-30 2009-01-13 Ethicon, Inc. Alpha-hydroxy sulfonate aldehydes, germicidal compositions containing the alpha-hydroxy sulfonate aldehydes, or mixtures of alpha-hydroxy sulfonate aldehydes and phthalaldehydes, and methods of using the compounds or compositions for disinfection or sterilization
US20050171216A1 (en) * 2004-01-30 2005-08-04 Zhu Peter C. Germicidal compositions containing phthalaldehyde mixtures and methods of using such compositions for disinfection or sterilization
US7291649B2 (en) * 2005-06-29 2007-11-06 Ethicon, Inc. Forming germicidal aromatic dialdehydes with acetals
KR20070073418A (en) * 2006-01-05 2007-07-10 주식회사 엘지화학 Method for inhibiting oxidation of aromatic dialdehyde
CN101932342B (en) * 2007-03-28 2015-03-04 怀特利集团控股有限公司 Sterilizing composition
US20090111895A1 (en) * 2007-10-31 2009-04-30 Ethicon, Inc. Enhanced dialdehyde disinfectant and sterilization formulations
US20110009493A1 (en) * 2008-02-12 2011-01-13 Larry Kent Hall Broad Spectrum Disinfecting and Sterilizing Composition
NZ603052A (en) * 2010-04-27 2014-10-31 Whiteley Corp Pty Ltd Synergystic, non-equilibrium aldehyde biocides
US9416278B2 (en) 2011-04-19 2016-08-16 Farshid Saboori Pigment dispersions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4971999A (en) * 1987-05-21 1990-11-20 Johnson & Johnson Medical, Inc. Odorless aromatic dialdehyde disinfecting and sterilizing composition and method of using the same
US4851449A (en) * 1987-05-21 1989-07-25 Surgikos, Inc. Odorless aromatic dialdehyde disinfecting and sterilizing composition
US4847304A (en) * 1987-05-21 1989-07-11 Surgikos, Inc. Disinfecting and sterilizing composition
US5128051A (en) * 1991-09-30 1992-07-07 Union Carbide Chemicals & Plastics Technology Corporation Method for the control of biofouling
US5158778A (en) † 1991-10-16 1992-10-27 Ecolab Inc. Stable antimicrobial dialdehyde composition and methods of use
AUPO336796A0 (en) † 1996-11-01 1996-11-28 Whiteley Industries Pty Ltd Ready-to-use glutaraldehyde concentrates

Also Published As

Publication number Publication date
EP0937395A1 (en) 1999-08-25
ES2200467T5 (en) 2010-08-19
DE69908206T3 (en) 2010-12-30
ES2200467T3 (en) 2004-03-01
CA2259707C (en) 2010-08-17
US6071972A (en) 2000-06-06
US5936001A (en) 1999-08-10
DE69908206T2 (en) 2004-03-25
EP0937395B2 (en) 2010-06-09
JP2000001406A (en) 2000-01-07
AU747387B2 (en) 2002-05-16
AU1318099A (en) 1999-08-12
EP0937395B1 (en) 2003-05-28
DE69908206D1 (en) 2003-07-03

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